miRTarBase - #MIRT439586


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pre-miRNA Information
pre-miRNA hsa-mir-544a   
Genomic Coordinates chr14: 101048658 - 101048748
Description Homo sapiens miR-544a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-544a
Sequence 55| AUUCUGCAUUUUUAGCAAGUUC |76
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1286637864 5 dbSNP
rs1394789797 9 dbSNP
rs1172200176 17 dbSNP
Putative Targets

Gene Information
Gene Symbol SMAD7   
Synonyms CRCS3, MADH7, MADH8
Description SMAD family member 7
Transcript NM_005904   
Expression
Putative miRNA Targets on SMAD7
3'UTR of SMAD7
(miRNA target sites are highlighted)		 
>SMAD7|NM_005904|3'UTR
   1 CCGCGTGCGGAGGGGACAGAGCGTGAGCTGAGCAGGCCACACTTCAAACTACTTTGCTGCTAATATTTTCCTCCTGAGTG
  81 CTTGCTTTTCATGCAAACTCTTTGGTCGTTTTTTTTTTGTTTGTTGGTTGGTTTTCTTCTTCTCGTCCTCGTTTGTGTTC
 161 TGTTTTGTTTCGCTCTTTGAGAAATAGCTTATGAAAAGAATTGTTGGGGGTTTTTTTGGAAGAAGGGGCAGGTATGATCG
 241 GCAGGACACCCTGATAGGAAGAGGGGAAGCAGAAATCCAAGCACCACCAAACACAGTGTATGAAGGGGGGCGGTCATCAT
 321 TTCACTTGTCAGGAGTGTGTGTGAGTGTGAGTGTGCGGCTGTGTGTGCACGCGTGTGCAGGAGCGGCAGATGGGGAGACA
 401 ACGTGCTCTTTGTTTTGTGTCTCTTATGGATGTCCCCAGCAGAGAGGTTTGCAGTCCCAAGCGGTGTCTCTCCTGCCCCT
 481 TGGACACGCTCAGTGGGGCAGAGGCAGTACCTGGGCAAGCTGGCGGCTGGGGTCCCAGCAGCTGCCAGGAGCACGGCTCT
 561 GTCCCCAGCCTGGGAAAGCCCCTGCCCCTCCTCTCCCTCATCAAGGACACGGGCCTGTCCACAGGCTTCTGAGCAGCGAG
 641 CCTGCTAGTGGCCGAACCAGAACCAATTATTTTCATCCTTGTCTTATTCCCTTCCTGCCAGCCCCTGCCATTGTAGCGTC
 721 TTTCTTTTTTGGCCATCTGCTCCTGGATCTCCCTGAGATGGGCTTCCCAAGGGCTGCCGGGGCAGCCCCCTCACAGTATT
 801 GCTCACCCAGTGCCCTCTCCCCTCAGCCTCTCCCCTGCCTGCCCTGGTGACATCAGGTTTTTCCCGGACTTAGAAAACCA
 881 GCTCAGCACTGCCTGCTCCCATCCTGTGTGTTAAGCTCTGCTATTAGGCCAGCAAGCGGGGATGTCCCTGGGAGGGACAT
 961 GCTTAGCAGTCCCCTTCCCTCCAAGAAGGATTTGGTCCGTCATAACCCAAGGTACCATCCTAGGCTGACACCTAACTCTT
1041 CTTTCATTTCTTCTACAACTCATACACTCGTATGATACTTCGACACTGTTCTTAGCTCAATGAGCATGTTTAGACTTTAA
1121 CATAAGCTATTTTTCTAACTACAAAGGTTTAAATGAACAAGAGAAGCATTCTCATTGGAAATTTAGCATTGTAGTGCTTT
1201 GAGAGAGAAAGGACTCCTGAAAAAAAACCTGAGATTTATTAAAGAAAAAAATGTATTTTATGTTATATATAAATATATTA
1281 TTACTTGTAAATATAAAGACGTTTTATAAGCATCATTATTTATGTATTGTGCAATGTGTATAAACAAGAAAAATAAAGAA
1361 AAGATGCACTTTGCTTTAATATAAATGCAAATAACAAATGCCAAATTAAAAAAGATAAACACAAGATTGGTGTTTTTTTC
1441 TATGGGTGTTATCACCTAGCTGAATGTTTTTCTAAAGGAGTTTATGTTCCATTAAACGATTTTTAAAATGTACACTTGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuugaacgauuuuUACGUCUUa 5'
                       :|||||:| 
Target 5' tgtgtgcacgcgtGTGCAGGAg 3'
 362 - 383 125.00 -9.50
2 
miRNA  3' cuugaacgauuuuuaCGUCUUa 5'
                         |||||| 
Target 5' ataggaagaggggaaGCAGAAa 3'
 254 - 275 120.00 -7.00
3 
miRNA  3' cuUG-AACG--AUU---UUUACGUCUua 5'
            || ||||  |||   ||||||| |  
Target 5' gcACTTTGCTTTAATATAAATGCAAAta 3'
 1366 - 1393 118.00 -8.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30117139 5 COSMIC
COSN30154233 6 COSMIC
COSN31552803 8 COSMIC
COSN30131659 9 COSMIC
COSN30186255 73 COSMIC
COSN15665032 109 COSMIC
COSN16382586 466 COSMIC
COSN21759492 521 COSMIC
COSN22291135 554 COSMIC
COSN4623342 563 COSMIC
COSN1206703 701 COSMIC
COSN6416475 937 COSMIC
COSN1206701 1000 COSMIC
COSN31588484 1300 COSMIC
COSN1745264 1381 COSMIC
COSN31487884 1472 COSMIC
COSN31550707 1477 COSMIC
rs8088297 902 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772790276 2 dbSNP
rs775583726 3 dbSNP
rs201583721 4 dbSNP
rs369794757 5 dbSNP
rs755317709 6 dbSNP
rs1428389313 7 dbSNP
rs749695963 8 dbSNP
rs374817806 9 dbSNP
rs766164966 13 dbSNP
rs756388652 14 dbSNP
rs1440184659 16 dbSNP
rs1171934476 20 dbSNP
rs750412898 21 dbSNP
rs778140885 21 dbSNP
rs371306207 22 dbSNP
rs181999754 23 dbSNP
rs1316252128 25 dbSNP
rs752657520 29 dbSNP
rs765304819 32 dbSNP
rs1258477732 36 dbSNP
rs759399169 38 dbSNP
rs753742300 39 dbSNP
rs200839822 43 dbSNP
rs1400049104 45 dbSNP
rs1329922083 52 dbSNP
rs1283743692 55 dbSNP
rs1337513116 71 dbSNP
rs567738728 72 dbSNP
rs547981346 91 dbSNP
rs982928086 92 dbSNP
rs951470175 93 dbSNP
rs1335884012 99 dbSNP
rs1027069950 100 dbSNP
rs979479154 107 dbSNP
rs74509535 108 dbSNP
rs571323547 109 dbSNP
rs765070862 115 dbSNP
rs1197982886 119 dbSNP
rs370493054 119 dbSNP
rs536375171 119 dbSNP
rs992388714 122 dbSNP
rs1412018855 123 dbSNP
rs778041467 125 dbSNP
rs1472066198 126 dbSNP
rs902978500 127 dbSNP
rs1033820152 130 dbSNP
rs1455778228 132 dbSNP
rs758773034 139 dbSNP
rs1043200023 144 dbSNP
rs979815233 144 dbSNP
rs969874135 145 dbSNP
rs1027051537 148 dbSNP
rs1224702887 150 dbSNP
rs995153451 151 dbSNP
rs1327883166 155 dbSNP
rs896829875 162 dbSNP
rs878890171 171 dbSNP
rs748601975 172 dbSNP
rs1208992857 191 dbSNP
rs1015478376 192 dbSNP
rs1265027558 198 dbSNP
rs1453211826 198 dbSNP
rs1200066379 203 dbSNP
rs1411228682 207 dbSNP
rs1008154944 210 dbSNP
rs1161515173 211 dbSNP
rs1364578631 212 dbSNP
rs1449260248 213 dbSNP
rs1393337030 218 dbSNP
rs573781177 218 dbSNP
rs890956100 225 dbSNP
rs1246640381 227 dbSNP
rs1039347602 228 dbSNP
rs944310382 229 dbSNP
rs1049628100 239 dbSNP
rs1308572515 241 dbSNP
rs1317088300 243 dbSNP
rs1210821055 280 dbSNP
rs779429503 284 dbSNP
rs982981918 287 dbSNP
rs1490782977 296 dbSNP
rs951530184 297 dbSNP
rs1250948974 301 dbSNP
rs932704016 306 dbSNP
rs903965913 307 dbSNP
rs1178974657 311 dbSNP
rs189546111 311 dbSNP
rs35564009 311 dbSNP
rs556999027 311 dbSNP
rs150355680 312 dbSNP
rs753844398 313 dbSNP
rs1024082449 314 dbSNP
rs1370483183 316 dbSNP
rs142857154 318 dbSNP
rs959983848 330 dbSNP
rs1285897714 334 dbSNP
rs1299344649 344 dbSNP
rs765119352 344 dbSNP
rs998688184 344 dbSNP
rs1373431828 347 dbSNP
rs145497223 348 dbSNP
rs780241593 353 dbSNP
rs1011757663 354 dbSNP
rs1246415023 356 dbSNP
rs992338069 356 dbSNP
rs939641672 357 dbSNP
rs1436796512 366 dbSNP
rs1206546346 369 dbSNP
rs943676346 370 dbSNP
rs926792683 371 dbSNP
rs368597621 372 dbSNP
rs775619167 373 dbSNP
rs930183203 376 dbSNP
rs952324168 377 dbSNP
rs1188267726 380 dbSNP
rs1388739274 384 dbSNP
rs974253014 385 dbSNP
rs1026710294 393 dbSNP
rs571503155 401 dbSNP
rs961036154 402 dbSNP
rs1015301797 403 dbSNP
rs1164332812 409 dbSNP
rs1008145157 412 dbSNP
rs891070098 417 dbSNP
rs1296516753 423 dbSNP
rs1362788816 429 dbSNP
rs1216173316 440 dbSNP
rs1388676431 444 dbSNP
rs1208078815 446 dbSNP
rs1190963480 453 dbSNP
rs1265101525 455 dbSNP
rs1028146405 456 dbSNP
rs996664435 462 dbSNP
rs903704110 463 dbSNP
rs1043778717 466 dbSNP
rs1230581971 470 dbSNP
rs960696152 473 dbSNP
rs1246378318 478 dbSNP
rs1196775754 479 dbSNP
rs1453389069 481 dbSNP
rs1030924931 485 dbSNP
rs945462191 487 dbSNP
rs548990258 488 dbSNP
rs1319461663 489 dbSNP
rs1290762491 493 dbSNP
rs1270596796 495 dbSNP
rs529214054 497 dbSNP
rs1217433037 502 dbSNP
rs184768687 503 dbSNP
rs1324384914 505 dbSNP
rs939589179 508 dbSNP
rs539998882 523 dbSNP
rs1266468366 524 dbSNP
rs981005478 525 dbSNP
rs1216891940 533 dbSNP
rs1246525353 536 dbSNP
rs577419796 539 dbSNP
rs552059104 545 dbSNP
rs1430688628 549 dbSNP
rs1480478394 552 dbSNP
rs535005355 554 dbSNP
rs930235378 555 dbSNP
rs1318677679 562 dbSNP
rs866373251 563 dbSNP
rs1402962152 572 dbSNP
rs1332317455 576 dbSNP
rs898737420 583 dbSNP
rs1038978857 589 dbSNP
rs1429649867 591 dbSNP
rs138939641 594 dbSNP
rs1353067674 597 dbSNP
rs1224547509 600 dbSNP
rs1170830283 605 dbSNP
rs986493010 608 dbSNP
rs955038649 610 dbSNP
rs375444823 611 dbSNP
rs1180761751 613 dbSNP
rs763925170 637 dbSNP
rs967873794 638 dbSNP
rs762864884 642 dbSNP
rs1422509771 648 dbSNP
rs1165282103 653 dbSNP
rs1366063034 654 dbSNP
rs774651067 663 dbSNP
rs545528146 668 dbSNP
rs1482662747 671 dbSNP
rs892577041 673 dbSNP
rs1249530952 675 dbSNP
rs752578673 687 dbSNP
rs990427230 691 dbSNP
rs1283817231 692 dbSNP
rs963921287 695 dbSNP
rs1248600566 696 dbSNP
rs569535091 697 dbSNP
rs556551791 701 dbSNP
rs1307851206 711 dbSNP
rs1003473726 713 dbSNP
rs905202953 715 dbSNP
rs192920849 717 dbSNP
rs765243506 718 dbSNP
rs1181986362 725 dbSNP
rs1236502992 729 dbSNP
rs1442448162 731 dbSNP
rs574239134 731 dbSNP
rs920769571 732 dbSNP
rs1036960315 735 dbSNP
rs1166078526 740 dbSNP
rs1398635733 744 dbSNP
rs1410578101 755 dbSNP
rs554512204 761 dbSNP
rs1025345226 769 dbSNP
rs993828941 770 dbSNP
rs759575565 772 dbSNP
rs534341189 778 dbSNP
rs867509104 779 dbSNP
rs571913988 780 dbSNP
rs765701945 783 dbSNP
rs920940062 783 dbSNP
rs975349269 790 dbSNP
rs1277339724 792 dbSNP
rs551491617 794 dbSNP
rs561142803 797 dbSNP
rs1056532336 807 dbSNP
rs1448641490 809 dbSNP
rs1190812554 810 dbSNP
rs939459430 818 dbSNP
rs1158428965 822 dbSNP
rs924014223 826 dbSNP
rs878956924 830 dbSNP
rs968410924 833 dbSNP
rs796951448 834 dbSNP
rs1172026929 838 dbSNP
rs946735872 839 dbSNP
rs1471043683 841 dbSNP
rs771438561 852 dbSNP
rs112439201 865 dbSNP
rs146277807 866 dbSNP
rs990097554 873 dbSNP
rs1320747522 881 dbSNP
rs1327481127 883 dbSNP
rs1233165890 884 dbSNP
rs964282909 885 dbSNP
rs911082613 886 dbSNP
rs1035026085 890 dbSNP
rs1263346621 894 dbSNP
rs1263378036 898 dbSNP
rs1485370444 898 dbSNP
rs1227183987 900 dbSNP
rs8088297 902 dbSNP
rs1289722787 903 dbSNP
rs1198090209 909 dbSNP
rs1427182193 910 dbSNP
rs1481456085 912 dbSNP
rs905193164 915 dbSNP
rs1025398002 923 dbSNP
rs1451925344 928 dbSNP
rs993880028 936 dbSNP
rs190053734 937 dbSNP
rs995081325 938 dbSNP
rs1347981782 941 dbSNP
rs1406226422 942 dbSNP
rs899440273 947 dbSNP
rs1301418050 956 dbSNP
rs770475283 957 dbSNP
rs1450637697 958 dbSNP
rs1036629303 959 dbSNP
rs1407029557 961 dbSNP
rs1236431853 963 dbSNP
rs940815903 964 dbSNP
rs760185024 971 dbSNP
rs1351109479 974 dbSNP
rs1455910824 979 dbSNP
rs1390890918 987 dbSNP
rs1012516882 989 dbSNP
rs890631443 989 dbSNP
rs1490833887 996 dbSNP
rs1050799536 998 dbSNP
rs933764051 999 dbSNP
rs920939123 1002 dbSNP
rs1056585107 1012 dbSNP
rs1364668222 1017 dbSNP
rs566293487 1019 dbSNP
rs1457694865 1023 dbSNP
rs772870815 1029 dbSNP
rs1367953301 1032 dbSNP
rs915116619 1034 dbSNP
rs988075875 1038 dbSNP
rs1243598709 1041 dbSNP
rs749624876 1055 dbSNP
rs956502551 1065 dbSNP
rs1207676825 1066 dbSNP
rs1308687335 1067 dbSNP
rs1034849335 1069 dbSNP
rs1244943853 1070 dbSNP
rs982157343 1073 dbSNP
rs564213920 1076 dbSNP
rs1250749416 1081 dbSNP
rs142341429 1082 dbSNP
rs915265001 1094 dbSNP
rs1054392979 1099 dbSNP
rs995217995 1100 dbSNP
rs1215922814 1103 dbSNP
rs1387473255 1108 dbSNP
rs1445710823 1112 dbSNP
rs1168499482 1119 dbSNP
rs1321570381 1122 dbSNP
rs1460000471 1126 dbSNP
rs867700214 1127 dbSNP
rs1299433946 1140 dbSNP
rs911136945 1142 dbSNP
rs546537391 1144 dbSNP
rs1312561875 1147 dbSNP
rs1384708689 1148 dbSNP
rs1015553080 1152 dbSNP
rs16950113 1153 dbSNP
rs563976086 1158 dbSNP
rs890621645 1166 dbSNP
rs972520421 1174 dbSNP
rs1297383856 1175 dbSNP
rs1433145008 1177 dbSNP
rs962751172 1184 dbSNP
rs1245267262 1201 dbSNP
rs747666259 1207 dbSNP
rs1445620049 1209 dbSNP
rs879185043 1211 dbSNP
rs1417968493 1218 dbSNP
rs933711843 1224 dbSNP
rs1430833772 1225 dbSNP
rs16950112 1227 dbSNP
rs1035231577 1228 dbSNP
rs1423728000 1228 dbSNP
rs959649699 1228 dbSNP
rs1453069299 1229 dbSNP
rs1289483893 1230 dbSNP
rs1288094573 1238 dbSNP
rs1359725469 1248 dbSNP
rs1216258521 1250 dbSNP
rs1457476077 1252 dbSNP
rs1349173440 1253 dbSNP
rs1003709874 1269 dbSNP
rs1221836857 1272 dbSNP
rs1265202991 1274 dbSNP
rs1461975745 1274 dbSNP
rs1162585918 1276 dbSNP
rs1240751864 1278 dbSNP
rs1487098733 1280 dbSNP
rs1187627902 1284 dbSNP
rs1268884474 1290 dbSNP
rs1039470466 1295 dbSNP
rs1426517067 1298 dbSNP
rs780905443 1300 dbSNP
rs576456351 1301 dbSNP
rs1430909650 1324 dbSNP
rs1385609677 1331 dbSNP
rs1187721536 1332 dbSNP
rs1158015725 1334 dbSNP
rs1343225308 1341 dbSNP
rs1432710296 1344 dbSNP
rs1289374367 1359 dbSNP
rs914917289 1361 dbSNP
rs754655289 1362 dbSNP
rs988009729 1362 dbSNP
rs1324490683 1363 dbSNP
rs563609312 1365 dbSNP
rs1319100962 1367 dbSNP
rs1217004478 1380 dbSNP
rs1268770975 1398 dbSNP
rs1490008745 1399 dbSNP
rs779303060 1411 dbSNP
rs1270414798 1423 dbSNP
rs902696994 1427 dbSNP
rs935287635 1433 dbSNP
rs1021056932 1439 dbSNP
rs1487863271 1440 dbSNP
rs562855336 1442 dbSNP
rs1422704651 1446 dbSNP
rs1304963055 1448 dbSNP
rs981938635 1450 dbSNP
rs1224393980 1452 dbSNP
rs769033832 1452 dbSNP
rs1375861657 1453 dbSNP
rs1224635760 1465 dbSNP
rs1291542509 1466 dbSNP
rs184940583 1476 dbSNP
rs1024115378 1497 dbSNP
rs574083465 1498 dbSNP
rs1203261985 1512 dbSNP
rs1470973072 1514 dbSNP
rs973515464 1518 dbSNP
rs963674156 1519 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
139 hsa-miR-544a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT053511 BMI1 BMI1 proto-oncogene, polycomb ring finger 4 1
MIRT054802 CDH1 cadherin 1 3 2
MIRT075814 ZCCHC14 zinc finger CCHC-type containing 14 2 3
MIRT125570 SCD stearoyl-CoA desaturase 1 1
MIRT246745 SF1 splicing factor 1 2 2
MIRT259487 TXLNG taxilin gamma 2 2
MIRT307650 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 2 2
MIRT377046 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT386936 STAT3 signal transducer and activator of transcription 3 3 1
MIRT394127 UBQLN1 ubiquilin 1 1 1
MIRT439199 ZNF483 zinc finger protein 483 1 1
MIRT439207 ZNF33A zinc finger protein 33A 1 1
MIRT439262 ZBTB17 zinc finger and BTB domain containing 17 1 1
MIRT439263 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 1 1
MIRT439281 XAB2 XPA binding protein 2 1 1
MIRT439314 VAT1 vesicle amine transport 1 1 1
MIRT439380 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439397 TPT1 tumor protein, translationally-controlled 1 1 1
MIRT439419 TMOD1 tropomodulin 1 1 1
MIRT439491 SYT5 synaptotagmin 5 1 1
MIRT439511 STXBP1 syntaxin binding protein 1 1 1
MIRT439586 SMAD7 SMAD family member 7 1 1
MIRT439727 RPS6 ribosomal protein S6 1 1
MIRT439768 RLIM ring finger protein, LIM domain interacting 1 1
MIRT439828 RAD50 RAD50 double strand break repair protein 1 1
MIRT439840 RAB21 RAB21, member RAS oncogene family 1 1
MIRT439846 RAB14 RAB14, member RAS oncogene family 1 1
MIRT439975 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 1 1
MIRT440031 PCDHAC2 protocadherin alpha subfamily C, 2 1 1
MIRT440135 NCOA2 nuclear receptor coactivator 2 1 1
MIRT440173 MTSS1L MTSS1L, I-BAR domain containing 1 1
MIRT440222 MMP2 matrix metallopeptidase 2 1 1
MIRT440433 IQGAP1 IQ motif containing GTPase activating protein 1 1 1
MIRT440443 INTS3 integrator complex subunit 3 1 1
MIRT440449 INS insulin 1 1
MIRT440512 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440534 GPR56 adhesion G protein-coupled receptor G1 1 1
MIRT440540 GOLGB1 golgin B1 1 1
MIRT440580 GEM GTP binding protein overexpressed in skeletal muscle 1 1
MIRT440629 FNDC3A fibronectin type III domain containing 3A 1 1
MIRT440667 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440680 CCSER1 coiled-coil serine rich protein 1 1 1
MIRT440696 FADS1 fatty acid desaturase 1 1 1
MIRT440761 DYNC1H1 dynein cytoplasmic 1 heavy chain 1 1 1
MIRT440764 DUSP26 dual specificity phosphatase 26 1 1
MIRT440769 DSTYK dual serine/threonine and tyrosine protein kinase 1 1
MIRT440774 DSP desmoplakin 1 1
MIRT440792 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 1 1
MIRT440801 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 1 1
MIRT440888 CPE carboxypeptidase E 1 1
MIRT440923 CLTC clathrin heavy chain 1 1
MIRT440950 CHD7 chromodomain helicase DNA binding protein 7 1 1
MIRT440993 CC2D2A coiled-coil and C2 domain containing 2A 1 1
MIRT441014 CAPN3 calpain 3 1 1
MIRT441106 BRD4 bromodomain containing 4 1 1
MIRT441144 ATP6V1B2 ATPase H+ transporting V1 subunit B2 1 1
MIRT441173 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT441258 ADM adrenomedullin 1 1
MIRT441279 ACTB actin beta 2 5
MIRT441298 ACACB acetyl-CoA carboxylase beta 1 1
MIRT443751 SLC7A14 solute carrier family 7 member 14 2 2
MIRT450469 TRMT5 tRNA methyltransferase 5 2 4
MIRT450852 HMGN2 high mobility group nucleosomal binding domain 2 2 6
MIRT454152 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT465705 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466121 TMEM170A transmembrane protein 170A 2 2
MIRT471376 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT477475 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT481660 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT502469 FAM98A family with sequence similarity 98 member A 2 8
MIRT503952 ZNF180 zinc finger protein 180 2 6
MIRT505585 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 6
MIRT529936 SYNGR1 synaptogyrin 1 2 2
MIRT530626 PPIC peptidylprolyl isomerase C 2 4
MIRT536883 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT546847 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT548448 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT557130 HOXA13 homeobox A13 2 2
MIRT560089 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT560984 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT566340 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT567838 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT609236 SERPINA4 serpin family A member 4 2 2
MIRT611452 ZWILCH zwilch kinetochore protein 2 2
MIRT612058 PDGFRA platelet derived growth factor receptor alpha 2 2
MIRT612783 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT615116 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT616572 C1orf56 chromosome 1 open reading frame 56 2 2
MIRT616690 LPL lipoprotein lipase 2 2
MIRT616986 COL19A1 collagen type XIX alpha 1 chain 2 2
MIRT619427 CYB5R3 cytochrome b5 reductase 3 2 2
MIRT623320 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT626897 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT637554 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT639473 SLC6A4 solute carrier family 6 member 4 2 2
MIRT639753 GPR45 G protein-coupled receptor 45 2 2
MIRT640703 MRS2 MRS2, magnesium transporter 2 2
MIRT642489 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT644578 SPOP speckle type BTB/POZ protein 2 2
MIRT645009 NGRN neugrin, neurite outgrowth associated 2 2
MIRT646533 KLK2 kallikrein related peptidase 2 2 2
MIRT648625 LEMD2 LEM domain containing 2 2 2
MIRT650235 ERI1 exoribonuclease 1 2 2
MIRT651932 UBN1 ubinuclein 1 2 2
MIRT652960 SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2 2
MIRT654842 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT656142 MSH5 mutS homolog 5 2 2
MIRT656730 LMBRD2 LMBR1 domain containing 2 2 2
MIRT657340 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT658991 DLGAP2 DLG associated protein 2 2 2
MIRT660714 AMER1 APC membrane recruitment protein 1 2 2
MIRT666591 RFX3 regulatory factor X3 2 2
MIRT667201 NKX2-3 NK2 homeobox 3 2 2
MIRT668732 DIO2 iodothyronine deiodinase 2 2 2
MIRT669479 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT681083 GSTO2 glutathione S-transferase omega 2 2 2
MIRT686736 STX16 syntaxin 16 2 2
MIRT687432 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT689887 SOD2 superoxide dismutase 2 2 2
MIRT695759 WDR35 WD repeat domain 35 2 2
MIRT698346 TMEM127 transmembrane protein 127 2 2
MIRT702752 IGF1R insulin like growth factor 1 receptor 2 2
MIRT703137 GPR137C G protein-coupled receptor 137C 2 2
MIRT705063 C4orf32 family with sequence similarity 241 member A 2 2
MIRT709597 IFT74 intraflagellar transport 74 2 2
MIRT709997 TXNDC12 thioredoxin domain containing 12 2 2
MIRT710463 ASTN2 astrotactin 2 2 2
MIRT710468 CDH5 cadherin 5 2 2
MIRT715625 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720091 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT721054 DCC DCC netrin 1 receptor 2 2
MIRT721961 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT722122 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT722538 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT723325 DGAT1 diacylglycerol O-acyltransferase 1 2 2
MIRT725330 NEUROD1 neuronal differentiation 1 2 2
MIRT731556 HOXA10 homeobox A10 2 1
MIRT732380 BCL6 B-cell CLL/lymphoma 6 3 1
MIRT736700 E2F5 E2F transcription factor 5 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-544a Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE450, TE-1)
hsa-miR-544a Trastuzumab sensitive High Breast Cancer cell line (SKBR3)
hsa-mir-544a Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-544a Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-544a Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-544a Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-544a Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-544a Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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