miRTarBase - #MIRT439922


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pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPL   
Synonyms -
Description periplakin
Transcript NM_002705   
Expression
Putative miRNA Targets on PPL
3'UTR of PPL
(miRNA target sites are highlighted)		 
>PPL|NM_002705|3'UTR
   1 GCACAGCTCTTGCAACTCTTCGTAACGGCAGACGCTGGCCCTCTCCTACGACGCAGTGACCTCCTTGGTGTCGTCCTCTC
  81 CCTAGCCCTGGTGCAGGCCAAGCATTTTATACATACCCTCGCTGCCAGGCTGCTCAGAGTCCCGCCCACATATGAGACAG
 161 GCACTGGCTGAAGACAGGCAACTCTCGTCCCAACCATCATTCACCCTGAGTGACGTACTTCATCCTCCAATGACTGGACA
 241 ACTGCGATGCCTTTTCCTCCCTTTTCCTGTACACTCCCAGCAACAAACTCCTCATGATAACTGCACACAATCTGAAAACC
 321 ACTGAAGGACAAGCCAACCACAGCAGCCAAGCCCACTCCTTGCAGCATGGGTACTGGTGGCACACCAGACAGTGACACTG
 401 CCCCACAAAGGCCTGGGCCCGTGGGGGCTGCTGCCTGGCATGACATCTCTCCAGATTTCTGGCTTAAAACCAACTTTCCA
 481 TCCGAGAAGCCTCCTCAGTAGTTACTCTGCTCATGAGACAGATCTGGGCTCCAAGCCAGGAAAGGTGAACAGAAACCACA
 561 AGTGTCCAGCCCTCGGTGCTGGAGTGGACGTTAATTGTCAGCCACCAGACTGTCCCGGCACCTACAGAGAATGTTTCACA
 641 GTTCTGGCATTTAAATCCTTTGATAGTGGATTGTGCTGCTGTTAGCCTTAGTTTCAGTGCTTTACAAGTCTCGCTTATTA
 721 TCTCACTGGTATTTAGGTATACAAAACAGTTGATTATTCACCACGCCAATATCTGGGTCTCTGTATCTCATGTAGAACAT
 801 AAGAAAATGGGAACTAATAGGGAAATTTATTTATAGCATGAAAATAAACCTGGTGGCTGGAGTCTGCTTGTACGGTCAAA
 881 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugCCGA---UC--ACCUGGUCCACUUca 5'
            ||||   ||   |||  |||||||  
Target 5' tgGGCTCCAAGCCAGGA-AAGGTGAAca 3'
 525 - 551 134.00 -15.10
2 
miRNA  3' ugccgaUCACCUGGUCCACUUCa 5'
                || | ||::| ||||| 
Target 5' tgagacAG-GCACTGGCTGAAGa 3'
 153 - 174 124.00 -11.00
3 
miRNA  3' ugccGAUCACCUGGUCCACUUCa 5'
              |||   | || |||| || 
Target 5' ctccCTA---GCCCTGGTGCAGg 3'
 78 - 97 120.00 -12.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30173673 18 COSMIC
COSN30475843 18 COSMIC
COSN31579861 22 COSMIC
COSN30125814 26 COSMIC
COSN6085740 74 COSMIC
COSN26990044 122 COSMIC
COSN26990046 155 COSMIC
COSN30150351 186 COSMIC
COSN30161212 245 COSMIC
COSN1187332 283 COSMIC
COSN7258670 401 COSMIC
COSN21021063 459 COSMIC
COSN21556726 695 COSMIC
COSN24039039 803 COSMIC
COSN31480140 874 COSMIC
rs1049212 456 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1428084445 2 dbSNP
rs766761343 5 dbSNP
rs758969944 12 dbSNP
rs750433049 13 dbSNP
rs753945933 14 dbSNP
rs765367667 15 dbSNP
rs761969791 18 dbSNP
rs1801936 21 dbSNP
rs760433061 22 dbSNP
rs764450371 24 dbSNP
rs371249534 26 dbSNP
rs745847776 27 dbSNP
rs376156723 28 dbSNP
rs115259132 29 dbSNP
rs748862161 31 dbSNP
rs1429440037 32 dbSNP
rs368647062 33 dbSNP
rs755869098 34 dbSNP
rs1445746512 39 dbSNP
rs747352107 41 dbSNP
rs201511569 46 dbSNP
rs569693403 49 dbSNP
rs368268972 50 dbSNP
rs757325905 51 dbSNP
rs374909646 52 dbSNP
rs989016974 53 dbSNP
rs984604178 54 dbSNP
rs1419812292 55 dbSNP
rs956205444 56 dbSNP
rs1166175756 60 dbSNP
rs45561532 62 dbSNP
rs1425833916 64 dbSNP
rs1303155536 65 dbSNP
rs1348473345 72 dbSNP
rs978822533 73 dbSNP
rs2734732 84 dbSNP
rs1028340243 87 dbSNP
rs1264607989 88 dbSNP
rs965767582 90 dbSNP
rs1360341329 91 dbSNP
rs1246581872 93 dbSNP
rs1291008393 96 dbSNP
rs1319649748 98 dbSNP
rs1217709882 102 dbSNP
rs1242268023 104 dbSNP
rs998563179 106 dbSNP
rs1186342422 112 dbSNP
rs1244442707 113 dbSNP
rs1322135887 114 dbSNP
rs966019307 116 dbSNP
rs1019263524 117 dbSNP
rs1004759774 120 dbSNP
rs141642158 121 dbSNP
rs1048893173 122 dbSNP
rs1402763399 135 dbSNP
rs1160295555 136 dbSNP
rs1229472980 140 dbSNP
rs374830812 142 dbSNP
rs1007200599 143 dbSNP
rs1338987115 144 dbSNP
rs1383585977 147 dbSNP
rs1452034782 153 dbSNP
rs954288009 154 dbSNP
rs769999051 155 dbSNP
rs1028545401 161 dbSNP
rs1284675671 173 dbSNP
rs1001037208 175 dbSNP
rs905588120 176 dbSNP
rs1264675967 181 dbSNP
rs1461341857 184 dbSNP
rs1421325803 187 dbSNP
rs1453065471 188 dbSNP
rs755068779 193 dbSNP
rs1236162898 194 dbSNP
rs1471450315 200 dbSNP
rs1408113667 208 dbSNP
rs1407673198 209 dbSNP
rs1338931741 210 dbSNP
rs1468445586 219 dbSNP
rs1044081677 222 dbSNP
rs1407152479 225 dbSNP
rs1168589044 228 dbSNP
rs904018886 229 dbSNP
rs1332285388 233 dbSNP
rs1371813733 241 dbSNP
rs1188555966 242 dbSNP
rs949732107 244 dbSNP
rs746784929 245 dbSNP
rs1280108942 246 dbSNP
rs1349630982 247 dbSNP
rs1226373518 263 dbSNP
rs1053771009 264 dbSNP
rs74003536 268 dbSNP
rs1275882243 269 dbSNP
rs1439116880 271 dbSNP
rs190067236 273 dbSNP
rs896510180 286 dbSNP
rs1056886047 288 dbSNP
rs1197014167 289 dbSNP
rs1202042106 294 dbSNP
rs373402710 294 dbSNP
rs751632029 299 dbSNP
rs544123467 304 dbSNP
rs1480223128 306 dbSNP
rs751453329 312 dbSNP
rs1192866275 322 dbSNP
rs1421704928 334 dbSNP
rs1269516932 337 dbSNP
rs1369910497 343 dbSNP
rs1407699277 347 dbSNP
rs1304748445 348 dbSNP
rs926124809 351 dbSNP
rs1232075209 373 dbSNP
rs978874789 374 dbSNP
rs758466137 377 dbSNP
rs921333174 383 dbSNP
rs926552360 385 dbSNP
rs74003535 387 dbSNP
rs1340071201 392 dbSNP
rs1329839284 393 dbSNP
rs1490299601 398 dbSNP
rs965759762 403 dbSNP
rs1411726092 404 dbSNP
rs1196998698 407 dbSNP
rs930518961 410 dbSNP
rs1475760430 413 dbSNP
rs1167413668 418 dbSNP
rs574011601 420 dbSNP
rs748069132 421 dbSNP
rs1365932600 426 dbSNP
rs1168438063 427 dbSNP
rs1004812876 435 dbSNP
rs1425848171 438 dbSNP
rs1327832282 445 dbSNP
rs1430744186 446 dbSNP
rs1296209553 448 dbSNP
rs76402697 452 dbSNP
rs911615444 454 dbSNP
rs1049212 456 dbSNP
rs1356031761 474 dbSNP
rs952985169 475 dbSNP
rs994644302 477 dbSNP
rs1264042063 478 dbSNP
rs905640558 482 dbSNP
rs186790318 483 dbSNP
rs1013955563 484 dbSNP
rs895477924 492 dbSNP
rs1052746589 498 dbSNP
rs934930250 503 dbSNP
rs1385819023 505 dbSNP
rs1021523736 507 dbSNP
rs1161252444 523 dbSNP
rs1386940325 539 dbSNP
rs1400925613 541 dbSNP
rs904753001 547 dbSNP
rs183466220 549 dbSNP
rs896576459 556 dbSNP
rs1454139857 557 dbSNP
rs1227498884 561 dbSNP
rs1316299343 564 dbSNP
rs932805810 567 dbSNP
rs921399085 571 dbSNP
rs554750953 574 dbSNP
rs905201410 575 dbSNP
rs1266528349 581 dbSNP
rs1462676808 587 dbSNP
rs944104581 589 dbSNP
rs540835603 590 dbSNP
rs1256697009 593 dbSNP
rs572526265 595 dbSNP
rs982757873 596 dbSNP
rs1365292892 597 dbSNP
rs1470416845 604 dbSNP
rs1157895828 605 dbSNP
rs930541840 606 dbSNP
rs950626225 609 dbSNP
rs1027560354 613 dbSNP
rs973271245 614 dbSNP
rs1400945722 615 dbSNP
rs146732490 616 dbSNP
rs538731595 617 dbSNP
rs1409249144 618 dbSNP
rs761528443 619 dbSNP
rs1228195330 622 dbSNP
rs1286609129 625 dbSNP
rs911633294 627 dbSNP
rs1159881722 632 dbSNP
rs1204608870 638 dbSNP
rs1482340392 641 dbSNP
rs1468286464 648 dbSNP
rs1250378292 655 dbSNP
rs374351953 662 dbSNP
rs1198637821 664 dbSNP
rs1199479805 665 dbSNP
rs1022763198 668 dbSNP
rs1490708378 670 dbSNP
rs1181195864 674 dbSNP
rs1014423488 677 dbSNP
rs1266678437 681 dbSNP
rs895540806 685 dbSNP
rs1031308775 690 dbSNP
rs1300368869 695 dbSNP
rs1464151691 695 dbSNP
rs753332167 696 dbSNP
rs1397838132 698 dbSNP
rs1409530948 699 dbSNP
rs904805432 702 dbSNP
rs1347851394 709 dbSNP
rs931668658 712 dbSNP
rs765956633 713 dbSNP
rs1229746358 718 dbSNP
rs1252935628 722 dbSNP
rs1043288047 725 dbSNP
rs1049223 726 dbSNP
rs765008770 731 dbSNP
rs192024798 735 dbSNP
rs1490792167 737 dbSNP
rs1191392899 740 dbSNP
rs1041180867 743 dbSNP
rs529642399 749 dbSNP
rs1430881385 750 dbSNP
rs368565417 751 dbSNP
rs1390308197 752 dbSNP
rs1021177871 762 dbSNP
rs1301826741 764 dbSNP
rs988724905 765 dbSNP
rs960868764 771 dbSNP
rs142656933 773 dbSNP
rs1346092782 774 dbSNP
rs1320729589 776 dbSNP
rs1405954335 781 dbSNP
rs1293117797 782 dbSNP
rs547982754 787 dbSNP
rs1365763421 789 dbSNP
rs1398545651 790 dbSNP
rs1296369701 793 dbSNP
rs1410727335 799 dbSNP
rs1272456595 802 dbSNP
rs566459469 802 dbSNP
rs905224193 803 dbSNP
rs931284230 817 dbSNP
rs1426602803 818 dbSNP
rs1487291944 818 dbSNP
rs762344692 820 dbSNP
rs774868109 821 dbSNP
rs1027628586 822 dbSNP
rs1187172644 824 dbSNP
rs7214 825 dbSNP
rs1406252977 827 dbSNP
rs1243579666 828 dbSNP
rs973323519 834 dbSNP
rs1321517823 835 dbSNP
rs1455536774 835 dbSNP
rs1464307780 850 dbSNP
rs1433020235 855 dbSNP
rs1267742267 857 dbSNP
rs969961867 860 dbSNP
rs571845132 867 dbSNP
rs369641437 870 dbSNP
rs536330769 873 dbSNP
rs944576824 874 dbSNP
rs1023238611 875 dbSNP
rs1319742474 877 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
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138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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