miRTarBase - #MIRT439952


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pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PLCB4   
Synonyms ARCND2, PI-PLC
Description phospholipase C beta 4
Transcript NM_001172646   
Other Transcripts NM_000933 , NM_182797   
Expression
Putative miRNA Targets on PLCB4
3'UTR of PLCB4
(miRNA target sites are highlighted)		 
>PLCB4|NM_001172646|3'UTR
   1 AACTCCAAAATGCAAACTGAAGCAGCAAACCCACAAAGCATCAAAAGACTCACTCACAAACTTCTGAACACAAACTCCAT
  81 GGATGAAAGCTGTTTATTTTGTTTCCTTTATGTGTAAACAAGATGATATCTGAAACCAGAGAGACTTGGAATGTCTGACT
 161 GACTTCTATTTAACAGCTTGAGTATTGCATTTCCTTGGCCAAACAAAAATAGCTACAAATCCACAAAAATTTACTATTCC
 241 AGTAAGGCAGAGTCCAACCATTGATAATACAACTTAAACATGTTTGCTATAAAATACCATCACAAGTAAATGAGCTTGGT
 321 GTGAACAACTCTCCTTTGTGATGCCTTAGGACATGTTTGAACTGCAGCAAAAAACAAAAACAAAAAACAGTGCATTAGCA
 401 ATTTCATAGCAAGTGCATGCACTAGGAAAAGAAAACTCTGTCTACAAGTTTATTAGCAGAAGTGGTGGTCTGCTAGACAA
 481 ATAATTTTGCAAAATTTTTCTACATCTAAGTTACCTCATCAGTAAGTGCCATGTCTCTACCATGCCATCAGAGGCTAATT
 561 TCCTGTAAAAGTTGTGGAAATTGTTAGAACAATAGAAAAATAGAGCAGTGTATGTGTGCCAAAACTCATCATTACTCAAA
 641 GGAGAACTGTGTTAGGCACATTTAAGAAAGTTTACATCTGACATTGCTTTATAGGAATTGTTTCTGCAGATTCCGGATAT
 721 TATAATTCACACCATAAAGATTGTGAAGTGGTTATTGGCAAACGTTTGTAAATGTGACCATGTATAAAGTATTTATACTC
 801 TTTAATTCACACTGTTAGAGAGCAAAATCATCTAAGTATTGCCACATGACAAGATTAGTAAACAGGAATACTAGAACTAT
 881 GTTTGCATGATACACAAGCACCAATAAAGACTAATCCATACACAGTTAACCTAATGCCAAATAAATACTGGTTAAATAAA
 961 TGTATGGCACAGAATATAATTTGACTATCAAGACTTTTAGCATAATGAAAAACCCTCTCTCTATATATATATGTGTATAT
1041 GAATTATGTGGGCATTCTTGATACTTCAAGTTCTAGTTTGAAAAAAATACATAACTAATTTAATTTTACACAAAAATATT
1121 TATGCAGATTTTCAGAATTTCATATCAGGAAATGACCTTTTTATGTCTGTTAAATATCAAAACAATTTGCTACAGTGTTA
1201 ATCTGCATGGTCTTTAAGCCTGCTGTAGTTGAGTTGCAGACAGTGCATGAAAAAGTATTCCGCTGGGAATTGAGCCATGC
1281 CACCAAAGCCAAGAGGAGCGCATGGAAACCCGGTAGTCTAGAACTAATCAGATTACTGATTTTAGGGCACAGCACCAGAT
1361 GAATTGTTGTATATGCTTGTAAAAATTGATTCTGTGTGTTCCTCTGAACAAAGCGGAGAAAATGATGATACCATCAATAT
1441 TGAAATTAAACTTCCAACTTCTCTAATAAAAAATTAAAACACGCATAACACTCGTCAAGAGTATTTGCTCCCAAGACACA
1521 TTCTAGCAAATGTTTTGCCTTTTTCATATACATGATATCATCGTTATTTTCAAAGGGGGCTTATTAATACCCTCAGCATG
1601 TTTTTCACCCAAATGATGCAAAACATGCAGATTCTAGTTGACTTCAGTTGTAATAGACTTGTTTTTCTCCTATTTATGAT
1681 TTGAAGTGGATTCTGTAAAATATCTCTTGTTCTTAGTTTCCTTATCTGTAAAACAGTGGAGTTAGACTACATATCTTTTG
1761 GCACTAACATCTCATGAAAAATTATGGTTAATAAAATATCACCACATTTGGATTGCCAATTTTCAAAAAAAAAAAAAAAA
1841 AAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugccgaucaccuggucCACUUCa 5'
                          |||||| 
Target 5' tcacaccataaagattGTGAAGt 3'
 727 - 749 120.00 -9.00
2 
miRNA  3' ugCCGAUCACCUGGUCCACUUca 5'
            ||| |  | ||||| ||||  
Target 5' agGGC-ACAGCACCAGATGAAtt 3'
 1344 - 1365 116.00 -10.90
3 
miRNA  3' ugcCGAUCAC---C-UGGUCCACUUCa 5'
             || ||||   | ||:|||  ||| 
Target 5' ataGCAAGTGCATGCACTAGGAAAAGa 3'
 406 - 432 104.00 -11.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
339596 85 ClinVar
339597 111 ClinVar
898912 130 ClinVar
339598 230 ClinVar
339599 251 ClinVar
339600 292 ClinVar
898913 364 ClinVar
339601 366 ClinVar
339602 395 ClinVar
339603 490 ClinVar
895954 491 ClinVar
339604 583 ClinVar
895955 607 ClinVar
895956 715 ClinVar
339605 759 ClinVar
895957 765 ClinVar
895958 806 ClinVar
896233 832 ClinVar
339606 890 ClinVar
896234 895 ClinVar
339607 976 ClinVar
339608 1024 ClinVar
339609 1032 ClinVar
896235 1039 ClinVar
896236 1068 ClinVar
339610 1125 ClinVar
897840 1157 ClinVar
897841 1212 ClinVar
339611 1223 ClinVar
897842 1241 ClinVar
897843 1313 ClinVar
897844 1326 ClinVar
339612 1374 ClinVar
898991 1376 ClinVar
898992 1423 ClinVar
898993 1433 ClinVar
339613 1482 ClinVar
339614 1508 ClinVar
339615 1601 ClinVar
898994 1631 ClinVar
339616 1691 ClinVar
339617 1752 ClinVar
339618 1787 ClinVar
COSM724633 7 COSMIC
COSM216498 10 COSMIC
COSM9140985 10 COSMIC
COSM6033279 19 COSMIC
COSM5392697 20 COSMIC
COSN31541362 32 COSMIC
COSN30474888 33 COSMIC
COSN20079843 65 COSMIC
COSN30461777 67 COSMIC
COSN30183194 78 COSMIC
COSN30140734 96 COSMIC
COSN19747909 116 COSMIC
COSN13875597 126 COSMIC
COSN31574020 206 COSMIC
COSN30110432 292 COSMIC
COSN31555341 393 COSMIC
COSN23015583 395 COSMIC
COSN31528357 441 COSMIC
COSN31481590 511 COSMIC
COSN8611389 527 COSMIC
COSN16131689 530 COSMIC
COSN31553701 550 COSMIC
COSN26580552 591 COSMIC
COSN23015584 600 COSMIC
COSN20093690 652 COSMIC
COSN31608239 663 COSMIC
COSN21808803 746 COSMIC
COSN26557262 765 COSMIC
COSN31535597 767 COSMIC
COSN6688867 797 COSMIC
COSN22118706 952 COSMIC
COSN7103673 1022 COSMIC
COSN29939442 1088 COSMIC
COSN31579731 1122 COSMIC
COSN8996002 1142 COSMIC
COSN28634498 1263 COSMIC
COSN31491123 1294 COSMIC
COSN28724510 1339 COSMIC
COSN21013005 1357 COSMIC
COSN31661399 1390 COSMIC
COSN17321487 1410 COSMIC
COSN30538699 1428 COSMIC
COSN31529171 1535 COSMIC
COSN5448208 1782 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746709075 9 dbSNP
rs1283895581 12 dbSNP
rs1042164114 13 dbSNP
rs756733720 17 dbSNP
rs1332559271 26 dbSNP
rs780825826 31 dbSNP
rs1432167828 32 dbSNP
rs1272414690 35 dbSNP
rs904612452 39 dbSNP
rs1218032244 43 dbSNP
rs745782291 49 dbSNP
rs761390098 53 dbSNP
rs764189746 53 dbSNP
rs972834843 56 dbSNP
rs375608152 70 dbSNP
rs919591824 76 dbSNP
rs889146883 77 dbSNP
rs372023385 85 dbSNP
rs1444844265 90 dbSNP
rs991080941 100 dbSNP
rs1260915636 106 dbSNP
rs554019512 111 dbSNP
rs1217307766 112 dbSNP
rs1008757792 113 dbSNP
rs1277846059 122 dbSNP
rs1018889385 124 dbSNP
rs949593893 130 dbSNP
rs1345966469 133 dbSNP
rs1276901835 138 dbSNP
rs868708224 141 dbSNP
rs1325980346 150 dbSNP
rs1298909358 157 dbSNP
rs574089289 169 dbSNP
rs41275610 171 dbSNP
rs1374176463 177 dbSNP
rs1173340255 183 dbSNP
rs1415460459 184 dbSNP
rs1265188231 188 dbSNP
rs543111231 192 dbSNP
rs993359507 199 dbSNP
rs1474125791 205 dbSNP
rs554654618 208 dbSNP
rs750084846 210 dbSNP
rs935427019 211 dbSNP
rs1255391568 214 dbSNP
rs189681230 216 dbSNP
rs980556936 221 dbSNP
rs576484180 230 dbSNP
rs1339018299 234 dbSNP
rs893815679 235 dbSNP
rs1220555788 237 dbSNP
rs1354100062 239 dbSNP
rs149256309 251 dbSNP
rs1361308801 258 dbSNP
rs917520080 261 dbSNP
rs1407815041 266 dbSNP
rs1399115143 267 dbSNP
rs1170760912 272 dbSNP
rs1028215416 282 dbSNP
rs889672306 290 dbSNP
rs2076392 292 dbSNP
rs1473098501 298 dbSNP
rs1238949579 299 dbSNP
rs1019426532 300 dbSNP
rs1437401452 303 dbSNP
rs977618920 306 dbSNP
rs1407778842 314 dbSNP
rs1332819657 320 dbSNP
rs112447507 322 dbSNP
rs1319558467 344 dbSNP
rs1050502552 349 dbSNP
rs1362028851 352 dbSNP
rs758778762 354 dbSNP
rs1442013370 355 dbSNP
rs1383469077 362 dbSNP
rs375356531 363 dbSNP
rs77776955 366 dbSNP
rs1331066035 367 dbSNP
rs1391591583 369 dbSNP
rs1163498808 377 dbSNP
rs1405817710 378 dbSNP
rs944729515 382 dbSNP
rs561281782 393 dbSNP
rs868076161 394 dbSNP
rs138221578 395 dbSNP
rs1238987730 405 dbSNP
rs1180795678 406 dbSNP
rs1467323714 412 dbSNP
rs1272580466 415 dbSNP
rs1222403358 417 dbSNP
rs993699323 418 dbSNP
rs990454489 419 dbSNP
rs1378183022 425 dbSNP
rs1311949182 429 dbSNP
rs916861850 431 dbSNP
rs6140952 455 dbSNP
rs1368343146 456 dbSNP
rs1292380810 466 dbSNP
rs1436643604 467 dbSNP
rs1351541316 471 dbSNP
rs1156886396 487 dbSNP
rs886056986 490 dbSNP
rs1380624719 495 dbSNP
rs1160263048 496 dbSNP
rs982726342 501 dbSNP
rs1452737208 505 dbSNP
rs1269074372 509 dbSNP
rs924124499 511 dbSNP
rs1191844469 516 dbSNP
rs1489530744 519 dbSNP
rs1240845296 533 dbSNP
rs1215645426 536 dbSNP
rs1176853424 540 dbSNP
rs1355084828 542 dbSNP
rs1288518270 556 dbSNP
rs1232571522 559 dbSNP
rs548638572 566 dbSNP
rs1345279077 568 dbSNP
rs539466607 573 dbSNP
rs148015873 583 dbSNP
rs1286631020 591 dbSNP
rs1208173133 593 dbSNP
rs1265127369 596 dbSNP
rs1361091266 603 dbSNP
rs767459614 607 dbSNP
rs752568109 612 dbSNP
rs893869384 613 dbSNP
rs967651195 625 dbSNP
rs978109863 633 dbSNP
rs1193048454 635 dbSNP
rs926108538 644 dbSNP
rs557767635 652 dbSNP
rs755400429 658 dbSNP
rs931998431 662 dbSNP
rs986158167 666 dbSNP
rs1233458638 673 dbSNP
rs1255029822 673 dbSNP
rs1313616502 674 dbSNP
rs1292731760 676 dbSNP
rs1052603187 677 dbSNP
rs1471522043 681 dbSNP
rs1341036269 684 dbSNP
rs1050374119 695 dbSNP
rs181298911 715 dbSNP
rs1008145262 716 dbSNP
rs910651548 724 dbSNP
rs944671828 725 dbSNP
rs1040380095 731 dbSNP
rs1478228830 737 dbSNP
rs919291073 737 dbSNP
rs929231745 742 dbSNP
rs1426369738 747 dbSNP
rs1291309576 750 dbSNP
rs41275612 759 dbSNP
rs1423766149 764 dbSNP
rs1257247669 765 dbSNP
rs1406097152 774 dbSNP
rs753278813 779 dbSNP
rs781310274 781 dbSNP
rs887586244 783 dbSNP
rs1255822336 785 dbSNP
rs1197426989 787 dbSNP
rs746087375 793 dbSNP
rs1318065236 797 dbSNP
rs185426541 809 dbSNP
rs1259460446 811 dbSNP
rs1349001659 814 dbSNP
rs994370592 820 dbSNP
rs1002050735 822 dbSNP
rs1339810181 824 dbSNP
rs551303407 832 dbSNP
rs1318983804 834 dbSNP
rs1371453060 839 dbSNP
rs189113726 842 dbSNP
rs1330976758 847 dbSNP
rs952425144 850 dbSNP
rs1013790821 852 dbSNP
rs1162917164 854 dbSNP
rs1457782068 857 dbSNP
rs1369558153 859 dbSNP
rs1190030502 879 dbSNP
rs1242629996 881 dbSNP
rs1235958959 882 dbSNP
rs1177571806 888 dbSNP
rs886056987 890 dbSNP
rs770044509 891 dbSNP
rs1020609867 892 dbSNP
rs1207565676 896 dbSNP
rs1023301889 902 dbSNP
rs902203046 916 dbSNP
rs775126715 918 dbSNP
rs1266033173 932 dbSNP
rs999100871 935 dbSNP
rs1351294761 942 dbSNP
rs533806290 953 dbSNP
rs1447744188 957 dbSNP
rs1379400431 960 dbSNP
rs924148007 962 dbSNP
rs1323901098 968 dbSNP
rs957508530 970 dbSNP
rs1223121679 974 dbSNP
rs114844715 976 dbSNP
rs1165561560 977 dbSNP
rs1452291815 988 dbSNP
rs989579637 996 dbSNP
rs915356294 1000 dbSNP
rs573728261 1014 dbSNP
rs1181227395 1015 dbSNP
rs1239683683 1015 dbSNP
rs1196129736 1016 dbSNP
rs1267942185 1022 dbSNP
rs536773247 1022 dbSNP
rs74772813 1024 dbSNP
rs576548131 1026 dbSNP
rs944671939 1031 dbSNP
rs866488779 1032 dbSNP
rs1273361121 1038 dbSNP
rs1232579284 1047 dbSNP
rs143716072 1049 dbSNP
rs565089581 1052 dbSNP
rs1325646754 1053 dbSNP
rs1305466748 1055 dbSNP
rs1360466326 1061 dbSNP
rs572706532 1068 dbSNP
rs1381750601 1071 dbSNP
rs1421982296 1071 dbSNP
rs1170500321 1072 dbSNP
rs1369287734 1076 dbSNP
rs1477503447 1079 dbSNP
rs1377654201 1081 dbSNP
rs909135961 1089 dbSNP
rs994028679 1092 dbSNP
rs1054961101 1096 dbSNP
rs896352542 1097 dbSNP
rs1217058493 1112 dbSNP
rs767443817 1117 dbSNP
rs886056988 1125 dbSNP
rs761898177 1142 dbSNP
rs1276273832 1144 dbSNP
rs181369739 1157 dbSNP
rs1345984542 1158 dbSNP
rs1431022745 1167 dbSNP
rs1216944711 1169 dbSNP
rs888233143 1175 dbSNP
rs1042552109 1180 dbSNP
rs1279434510 1186 dbSNP
rs772886179 1190 dbSNP
rs902155143 1195 dbSNP
rs1012001856 1210 dbSNP
rs1023352208 1212 dbSNP
rs1248318382 1213 dbSNP
rs1476592775 1216 dbSNP
rs114009007 1223 dbSNP
rs1194360075 1240 dbSNP
rs760378772 1243 dbSNP
rs777390185 1246 dbSNP
rs1340001192 1261 dbSNP
rs187212972 1263 dbSNP
rs1443202079 1282 dbSNP
rs1281079905 1291 dbSNP
rs766148839 1298 dbSNP
rs957158917 1300 dbSNP
rs1258823132 1303 dbSNP
rs1220954642 1313 dbSNP
rs1377625881 1325 dbSNP
rs989635266 1326 dbSNP
rs1449285048 1328 dbSNP
rs752959776 1333 dbSNP
rs1340694273 1337 dbSNP
rs530208771 1342 dbSNP
rs915400686 1349 dbSNP
rs1463584588 1350 dbSNP
rs542346937 1353 dbSNP
rs986179703 1354 dbSNP
rs976175011 1360 dbSNP
rs758798860 1361 dbSNP
rs944735150 1372 dbSNP
rs192145916 1374 dbSNP
rs1388801100 1376 dbSNP
rs1239411784 1380 dbSNP
rs1036756087 1384 dbSNP
rs531253220 1395 dbSNP
rs950713421 1397 dbSNP
rs918542081 1401 dbSNP
rs929872185 1402 dbSNP
rs551360025 1415 dbSNP
rs764453740 1416 dbSNP
rs1012054044 1419 dbSNP
rs1171480254 1423 dbSNP
rs1364901728 1428 dbSNP
rs1289875554 1429 dbSNP
rs1356634152 1431 dbSNP
rs752095719 1433 dbSNP
rs1302455383 1434 dbSNP
rs906251276 1436 dbSNP
rs1383844764 1440 dbSNP
rs1003233690 1452 dbSNP
rs1444038433 1458 dbSNP
rs1295515512 1467 dbSNP
rs917738187 1474 dbSNP
rs886056989 1482 dbSNP
rs956985186 1483 dbSNP
rs1011109485 1484 dbSNP
rs1273698525 1486 dbSNP
rs902270125 1490 dbSNP
rs1156616532 1491 dbSNP
rs1022462737 1494 dbSNP
rs757831235 1495 dbSNP
rs986231855 1502 dbSNP
rs1487569270 1506 dbSNP
rs546587344 1508 dbSNP
rs182656088 1509 dbSNP
rs1453840639 1513 dbSNP
rs547353766 1521 dbSNP
rs1239952510 1530 dbSNP
rs1352521212 1534 dbSNP
rs972126655 1546 dbSNP
rs1224949020 1550 dbSNP
rs1474832369 1553 dbSNP
rs919250185 1563 dbSNP
rs567488882 1564 dbSNP
rs930593480 1565 dbSNP
rs1437021592 1575 dbSNP
rs984046948 1575 dbSNP
rs1367381656 1579 dbSNP
rs1296099501 1584 dbSNP
rs1422327641 1589 dbSNP
rs1413086424 1593 dbSNP
rs1381118123 1601 dbSNP
rs565091978 1601 dbSNP
rs886056990 1601 dbSNP
rs909772285 1611 dbSNP
rs947887657 1614 dbSNP
rs1424496788 1618 dbSNP
rs530936521 1626 dbSNP
rs1026358274 1638 dbSNP
rs1261741144 1644 dbSNP
rs950859121 1647 dbSNP
rs1006342100 1648 dbSNP
rs1488852157 1652 dbSNP
rs1288637217 1655 dbSNP
rs1217447442 1662 dbSNP
rs1045282914 1666 dbSNP
rs1310083195 1674 dbSNP
rs906311299 1675 dbSNP
rs1471081552 1687 dbSNP
rs1219362220 1690 dbSNP
rs1347312428 1691 dbSNP
rs886056991 1691 dbSNP
rs1276269479 1694 dbSNP
rs1399140801 1703 dbSNP
rs745998989 1706 dbSNP
rs1016259033 1710 dbSNP
rs1290442889 1714 dbSNP
rs536443567 1720 dbSNP
rs959382226 1724 dbSNP
rs1176873289 1726 dbSNP
rs186199616 1731 dbSNP
rs990709790 1738 dbSNP
rs1193519890 1739 dbSNP
rs892132715 1742 dbSNP
rs1478454400 1750 dbSNP
rs147197006 1752 dbSNP
rs978334093 1755 dbSNP
rs1022513700 1756 dbSNP
rs1203711648 1762 dbSNP
rs1364025484 1764 dbSNP
rs936417773 1765 dbSNP
rs889340074 1770 dbSNP
rs1217892968 1775 dbSNP
rs1007757327 1781 dbSNP
rs371725616 1782 dbSNP
rs1394143723 1786 dbSNP
rs189786768 1787 dbSNP
rs1323713027 1792 dbSNP
rs1205167204 1799 dbSNP
rs1454805218 1803 dbSNP
rs558923225 1805 dbSNP
rs1265914737 1814 dbSNP
rs1226483988 1816 dbSNP
rs1170067689 1820 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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