miRTarBase - #MIRT439963


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PKD1   
Synonyms PBP, PC1, Pc-1, TRPP1
Description polycystin 1, transient receptor potential channel interacting
Transcript NM_000296   
Other Transcripts NM_001009944   
Expression
Putative miRNA Targets on PKD1
3'UTR of PKD1
(miRNA target sites are highlighted)		 
>PKD1|NM_000296|3'UTR
   1 TCCTCCTTCCTGGCGGGGGTGGGCCGTGGAGTCGGAGTGGACACCGCTCAGTATTACTTTCTGCCGCTGTCAAGGCCGAG
  81 GGCCAGGCAGAATGGCTGCACGTAGGTTCCCCAGAGAGCAGGCAGGGGCATCTGTCTGTCTGTGGGCTTCAGCACTTTAA
 161 AGAGGCTGTGTGGCCAACCAGGACCCAGGGTCCCCTCCCCAGCTCCCTTGGGAAGGACACAGCAGTATTGGACGGTTTCT
 241 AGCCTCTGAGATGCTAATTTATTTCCCCGAGTCCTCAGGTACAGCGGGCTGTGCCCGGCCCCACCCCCTGGGCAGATGTC
 321 CCCCACTGCTAAGGCTGCTGGCTTCAGGGAGGGTTAGCCTGCACCGCCGCCACCCTGCCCCTAAGTTATTACCTCTCCAG
 401 TTCCTACCGTACTCCCTGCACCGTCTCACTGTGTGTCTCGTGTCAGTAATTTATATGGTGTTAAAATGTGTATATTTTTG
 481 TATGTCACTATTTTCACTAGGGCTGAGGGGCCTGCGCCCAGAGCTGGCCTCCCCCAACACCTGCTGCGCTTGGTAGGTGT
 561 GGTGGCGTTATGGCAGCCCGGCTGCTGCTTGGATGCGAGCTTGGCCTTGGGCCGGTGCTGGGGGCACAGCTGTCTGCCAG
 641 GCACTCTCATCACCCCAGAGGCCTTGTCATCCTCCCTTGCCCCAGGCCAGGTAGCAAGAGAGCAGCGCCCAGGCCTGCTG
 721 GCATCAGGTCTGGGCAAGTAGCAGGACTAGGCATGTCAGAGGACCCCAGGGTGGTTAGAGGAAAAGACTCCTCCTGGGGG
 801 CTGGCTCCCAGGGTGGAGGAAGGTGACTGTGTGTGTGTGTGTGTGCGCGCGCGCACGCGCGAGTGTGCTGTATGGCCCAG
 881 GCAGCCTCAAGGCCCTCGGAGCTGGCTGTGCCTGCTTCTGTGTACCACTTCTGTGGGCATGGCCGCTTCTAGAGCCTCGA
 961 CACCCCCCCAACCCCCGCACCAAGCAGACAAAGTCAATAAAAGAGCTGTCTGACTGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagucucgGGAGACUCGAAGUc 5'
                  :|| ||:|||||| 
Target 5' tctgtctgTCTGTGGGCTTCAg 3'
 131 - 152 142.00 -19.40
2 
miRNA  3' uagucUCGGGAGACUCGAAGUc 5'
               || |: || :|||||| 
Target 5' tgctaAGGCTGCT-GGCTTCAg 3'
 327 - 347 136.00 -18.20
3 
miRNA  3' uaGUCUCGGGAGACUCGAaguc 5'
            || :|||||| |||||    
Target 5' ctCAAGGCCCTCGGAGCTggct 3'
 886 - 907 120.00 -21.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
256884 15 ClinVar
1049696 846 ClinVar
1194539 848 ClinVar
1180280 855 ClinVar
1178576 862 ClinVar
64862 970 ClinVar
65179 977 ClinVar
65208 989 ClinVar
65144 990 ClinVar
65276 990 ClinVar
COSN20078604 14 COSMIC
COSN31537968 40 COSMIC
COSN31488061 44 COSMIC
COSN15660759 109 COSMIC
COSN20093050 194 COSMIC
COSN31489930 233 COSMIC
COSN7300909 297 COSMIC
COSN26769728 302 COSMIC
COSN30543727 304 COSMIC
COSN27564835 409 COSMIC
COSN6644781 601 COSMIC
COSN26257692 717 COSMIC
COSN22236664 835 COSMIC
COSN20112544 844 COSMIC
COSN23987363 844 COSMIC
COSN30554789 963 COSMIC
COSN31597361 993 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs779509501 2 dbSNP
rs755569329 3 dbSNP
rs1164276235 5 dbSNP
rs749884546 6 dbSNP
rs767068030 8 dbSNP
rs367762249 9 dbSNP
rs764028522 10 dbSNP
rs373918732 14 dbSNP
rs77566834 15 dbSNP
rs113679594 17 dbSNP
rs1452487267 19 dbSNP
rs1195749154 20 dbSNP
rs1452940660 23 dbSNP
rs759478253 24 dbSNP
rs776638372 25 dbSNP
rs1374846916 26 dbSNP
rs1384723785 26 dbSNP
rs771102722 28 dbSNP
rs566279575 29 dbSNP
rs112780826 33 dbSNP
rs530758271 34 dbSNP
rs1275189794 35 dbSNP
rs1438408130 36 dbSNP
rs562017501 37 dbSNP
rs1435325131 38 dbSNP
rs1325564344 39 dbSNP
rs1436097985 41 dbSNP
rs368143590 42 dbSNP
rs755484175 44 dbSNP
rs541715653 45 dbSNP
rs375155193 46 dbSNP
rs926703768 47 dbSNP
rs1464656598 48 dbSNP
rs559096849 49 dbSNP
rs1477276969 50 dbSNP
rs1440702204 53 dbSNP
rs1186765144 56 dbSNP
rs982607400 57 dbSNP
rs540358072 60 dbSNP
rs997006362 61 dbSNP
rs901377656 63 dbSNP
rs577702794 64 dbSNP
rs557909051 65 dbSNP
rs372311716 66 dbSNP
rs1290262392 67 dbSNP
rs538237594 68 dbSNP
rs1399454620 69 dbSNP
rs908803184 71 dbSNP
rs1341634726 75 dbSNP
rs972083553 76 dbSNP
rs575504362 77 dbSNP
rs556035783 78 dbSNP
rs1229253042 82 dbSNP
rs535740062 84 dbSNP
rs1482328984 87 dbSNP
rs1199898398 90 dbSNP
rs1236128331 91 dbSNP
rs777483574 98 dbSNP
rs926356423 99 dbSNP
rs980518122 100 dbSNP
rs953677462 101 dbSNP
rs949213110 102 dbSNP
rs917781648 106 dbSNP
rs987992910 109 dbSNP
rs998332804 110 dbSNP
rs956796992 111 dbSNP
rs185343851 112 dbSNP
rs773278017 113 dbSNP
rs1032270911 114 dbSNP
rs1042428027 114 dbSNP
rs2855368 115 dbSNP
rs1299583763 118 dbSNP
rs1412419653 119 dbSNP
rs754881835 121 dbSNP
rs1009215377 122 dbSNP
rs978742004 123 dbSNP
rs547199668 124 dbSNP
rs968737633 126 dbSNP
rs1310703688 127 dbSNP
rs1028404925 128 dbSNP
rs996975085 129 dbSNP
rs1256725407 130 dbSNP
rs1350137871 131 dbSNP
rs1053648230 132 dbSNP
rs937806465 132 dbSNP
rs1178770447 134 dbSNP
rs1483279385 134 dbSNP
rs901261694 137 dbSNP
rs1020167534 138 dbSNP
rs1199130729 139 dbSNP
rs772300257 140 dbSNP
rs1046265575 143 dbSNP
rs777664625 144 dbSNP
rs919377188 145 dbSNP
rs887335186 147 dbSNP
rs1048664501 151 dbSNP
rs963389051 152 dbSNP
rs930966731 159 dbSNP
rs1304355286 160 dbSNP
rs909422258 160 dbSNP
rs904900456 161 dbSNP
rs1044788614 162 dbSNP
rs113262713 164 dbSNP
rs917681089 166 dbSNP
rs1186012029 168 dbSNP
rs748485709 168 dbSNP
rs1273971562 172 dbSNP
rs1308058698 173 dbSNP
rs988349329 174 dbSNP
rs1263532381 178 dbSNP
rs1487998834 179 dbSNP
rs1210080735 180 dbSNP
rs1254435440 183 dbSNP
rs997720002 184 dbSNP
rs1256997317 189 dbSNP
rs935194889 190 dbSNP
rs878903703 192 dbSNP
rs539581650 193 dbSNP
rs1457668261 198 dbSNP
rs1326867294 200 dbSNP
rs1397012843 203 dbSNP
rs774721414 205 dbSNP
rs1219643535 207 dbSNP
rs1320401594 210 dbSNP
rs1020674438 216 dbSNP
rs570557165 220 dbSNP
rs550355361 221 dbSNP
rs1320918487 227 dbSNP
rs530534662 228 dbSNP
rs867756350 230 dbSNP
rs1463303300 231 dbSNP
rs1339480270 233 dbSNP
rs561489343 234 dbSNP
rs1053597274 236 dbSNP
rs1412197969 239 dbSNP
rs769291648 243 dbSNP
rs139573366 244 dbSNP
rs905132047 250 dbSNP
rs1330544126 253 dbSNP
rs1320066659 256 dbSNP
rs1046644604 258 dbSNP
rs949259809 260 dbSNP
rs1425565939 264 dbSNP
rs1162488321 265 dbSNP
rs766153620 265 dbSNP
rs919309114 265 dbSNP
rs528351015 266 dbSNP
rs1472632292 267 dbSNP
rs1004771537 268 dbSNP
rs752472135 269 dbSNP
rs941974355 269 dbSNP
rs779759485 271 dbSNP
rs909207729 273 dbSNP
rs1436089216 276 dbSNP
rs1207464260 278 dbSNP
rs995753401 278 dbSNP
rs559158862 283 dbSNP
rs1485665373 284 dbSNP
rs545586456 285 dbSNP
rs1044675322 286 dbSNP
rs949067437 287 dbSNP
rs1158739459 295 dbSNP
rs1271709209 295 dbSNP
rs896198372 296 dbSNP
rs181814805 297 dbSNP
rs935155314 298 dbSNP
rs1284354761 299 dbSNP
rs1246387958 302 dbSNP
rs1314572263 303 dbSNP
rs755653968 304 dbSNP
rs1408939851 305 dbSNP
rs1333424347 306 dbSNP
rs925181097 308 dbSNP
rs1277385607 311 dbSNP
rs745341634 318 dbSNP
rs564609458 328 dbSNP
rs544340999 329 dbSNP
rs1283034920 330 dbSNP
rs1020622120 337 dbSNP
rs987859249 338 dbSNP
rs921861004 341 dbSNP
rs957822502 348 dbSNP
rs975387518 349 dbSNP
rs575611619 350 dbSNP
rs555453899 351 dbSNP
rs1001905592 352 dbSNP
rs1435354719 353 dbSNP
rs752234831 354 dbSNP
rs1368587863 359 dbSNP
rs912624205 362 dbSNP
rs982921818 364 dbSNP
rs73498118 365 dbSNP
rs756873400 366 dbSNP
rs751313275 368 dbSNP
rs1013795627 369 dbSNP
rs573566934 369 dbSNP
rs187331220 370 dbSNP
rs1274228192 373 dbSNP
rs1036227896 378 dbSNP
rs1442160215 379 dbSNP
rs1252554414 380 dbSNP
rs942093738 385 dbSNP
rs1195619933 389 dbSNP
rs1251612403 391 dbSNP
rs1388388206 391 dbSNP
rs887887822 392 dbSNP
rs1050406101 393 dbSNP
rs1221299997 395 dbSNP
rs540040398 398 dbSNP
rs923495188 399 dbSNP
rs1322515397 402 dbSNP
rs1394818339 404 dbSNP
rs1290175680 405 dbSNP
rs181780746 408 dbSNP
rs758383845 409 dbSNP
rs946172953 410 dbSNP
rs1052613746 412 dbSNP
rs999245923 414 dbSNP
rs903614823 415 dbSNP
rs990301126 416 dbSNP
rs957770047 417 dbSNP
rs1043550238 419 dbSNP
rs752613073 420 dbSNP
rs766489027 421 dbSNP
rs921828318 422 dbSNP
rs190152551 423 dbSNP
rs1374687403 425 dbSNP
rs545371620 427 dbSNP
rs1025276182 428 dbSNP
rs1331423414 428 dbSNP
rs568078250 429 dbSNP
rs944028454 430 dbSNP
rs1013493799 431 dbSNP
rs897787085 431 dbSNP
rs1383632228 433 dbSNP
rs1382248077 437 dbSNP
rs367951136 437 dbSNP
rs762793687 437 dbSNP
rs912603398 437 dbSNP
rs373639226 439 dbSNP
rs547863566 440 dbSNP
rs1266421244 442 dbSNP
rs920022480 445 dbSNP
rs887834107 446 dbSNP
rs1205840255 449 dbSNP
rs974186957 449 dbSNP
rs1440683686 455 dbSNP
rs1187127746 456 dbSNP
rs1257967786 458 dbSNP
rs969550464 461 dbSNP
rs1156532485 462 dbSNP
rs1023827234 467 dbSNP
rs1159339894 470 dbSNP
rs1421519298 472 dbSNP
rs1013879243 474 dbSNP
rs528412312 476 dbSNP
rs1312745441 478 dbSNP
rs1030634516 483 dbSNP
rs1356530770 485 dbSNP
rs999612084 486 dbSNP
rs1335453578 488 dbSNP
rs1478628296 488 dbSNP
rs1262632179 491 dbSNP
rs1342874893 492 dbSNP
rs1210090435 493 dbSNP
rs773297182 497 dbSNP
rs1179796466 499 dbSNP
rs1249530471 500 dbSNP
rs556570291 502 dbSNP
rs1191477301 503 dbSNP
rs946283973 509 dbSNP
rs1487136580 510 dbSNP
rs1375443119 512 dbSNP
rs565636902 514 dbSNP
rs183979118 515 dbSNP
rs1043518994 516 dbSNP
rs1355180878 518 dbSNP
rs1437103279 519 dbSNP
rs1276450855 521 dbSNP
rs1396214248 521 dbSNP
rs1218626538 524 dbSNP
rs1345592862 527 dbSNP
rs936190439 533 dbSNP
rs1233605223 534 dbSNP
rs1350023749 535 dbSNP
rs924992457 537 dbSNP
rs1250555041 540 dbSNP
rs980553044 541 dbSNP
rs1264780194 542 dbSNP
rs1397901251 542 dbSNP
rs2854588 543 dbSNP
rs995998310 544 dbSNP
rs772899303 546 dbSNP
rs1040691772 547 dbSNP
rs944599331 548 dbSNP
rs1168866134 549 dbSNP
rs1372878470 551 dbSNP
rs1357548708 552 dbSNP
rs1175405885 553 dbSNP
rs961944453 563 dbSNP
rs1300143432 564 dbSNP
rs762029876 565 dbSNP
rs764840200 566 dbSNP
rs774922931 566 dbSNP
rs769130086 567 dbSNP
rs532185158 568 dbSNP
rs749851663 569 dbSNP
rs1212750775 570 dbSNP
rs974154277 571 dbSNP
rs1271018020 572 dbSNP
rs901964044 577 dbSNP
rs563305714 579 dbSNP
rs776172110 580 dbSNP
rs1463113897 581 dbSNP
rs1185305742 586 dbSNP
rs544713931 587 dbSNP
rs1261589936 590 dbSNP
rs1429595075 593 dbSNP
rs1235286089 596 dbSNP
rs892023610 597 dbSNP
rs3087631 601 dbSNP
rs936136687 603 dbSNP
rs992746427 604 dbSNP
rs1288334335 605 dbSNP
rs1280562010 607 dbSNP
rs1383841911 609 dbSNP
rs960961194 613 dbSNP
rs371496391 614 dbSNP
rs1233535642 616 dbSNP
rs977769185 619 dbSNP
rs1274605142 621 dbSNP
rs776141886 622 dbSNP
rs1314645231 624 dbSNP
rs1214502012 626 dbSNP
rs1216604235 627 dbSNP
rs1317019506 631 dbSNP
rs927473939 633 dbSNP
rs1044995706 634 dbSNP
rs1420343599 636 dbSNP
rs947813833 636 dbSNP
rs1158546067 637 dbSNP
rs577209727 637 dbSNP
rs542240060 638 dbSNP
rs1345853942 640 dbSNP
rs573226497 642 dbSNP
rs917690037 643 dbSNP
rs780683017 644 dbSNP
rs967735315 645 dbSNP
rs1294871627 646 dbSNP
rs1022045835 649 dbSNP
rs984714341 649 dbSNP
rs1222839520 651 dbSNP
rs1284427532 653 dbSNP
rs995965746 654 dbSNP
rs900255572 656 dbSNP
rs1278764122 657 dbSNP
rs1485612752 657 dbSNP
rs951976370 658 dbSNP
rs768097806 661 dbSNP
rs1018745193 666 dbSNP
rs1028824293 669 dbSNP
rs1465457113 670 dbSNP
rs996440305 672 dbSNP
rs1424855757 676 dbSNP
rs3743870 678 dbSNP
rs1009159039 679 dbSNP
rs1314557101 680 dbSNP
rs1352541452 681 dbSNP
rs886332968 682 dbSNP
rs1173234001 683 dbSNP
rs1279712589 685 dbSNP
rs966125943 685 dbSNP
rs756923313 686 dbSNP
rs553711172 687 dbSNP
rs1010152405 688 dbSNP
rs1235658417 690 dbSNP
rs891803760 691 dbSNP
rs1204114312 695 dbSNP
rs111786159 696 dbSNP
rs1459236575 698 dbSNP
rs1191885624 700 dbSNP
rs774921866 701 dbSNP
rs1394547035 702 dbSNP
rs1454709740 703 dbSNP
rs368013485 706 dbSNP
rs746657260 707 dbSNP
rs1329261652 711 dbSNP
rs1038339239 714 dbSNP
rs1438241694 715 dbSNP
rs1324709579 716 dbSNP
rs1371003477 717 dbSNP
rs777597080 718 dbSNP
rs1337895323 719 dbSNP
rs1214394495 721 dbSNP
rs916666157 722 dbSNP
rs1320348921 723 dbSNP
rs1212054987 724 dbSNP
rs1180789393 725 dbSNP
rs1472816591 726 dbSNP
rs1200942487 729 dbSNP
rs867318438 732 dbSNP
rs1044559724 735 dbSNP
rs577387279 738 dbSNP
rs191697830 739 dbSNP
rs896214489 742 dbSNP
rs1163685077 744 dbSNP
rs1394606039 745 dbSNP
rs771261310 747 dbSNP
rs978783873 750 dbSNP
rs1258541403 751 dbSNP
rs868402230 751 dbSNP
rs1325255215 753 dbSNP
rs967702702 755 dbSNP
rs1021929742 758 dbSNP
rs1320154059 758 dbSNP
rs1312193120 761 dbSNP
rs1056230385 767 dbSNP
rs974412944 769 dbSNP
rs1231701088 770 dbSNP
rs1228996345 771 dbSNP
rs758162646 773 dbSNP
rs1381368270 774 dbSNP
rs537187222 776 dbSNP
rs1474073094 778 dbSNP
rs907531409 778 dbSNP
rs984495309 781 dbSNP
rs572959816 786 dbSNP
rs568867686 788 dbSNP
rs568056589 789 dbSNP
rs577103612 790 dbSNP
rs1342799987 793 dbSNP
rs1405567448 796 dbSNP
rs1293039413 801 dbSNP
rs1356403314 805 dbSNP
rs565298575 810 dbSNP
rs187992537 812 dbSNP
rs1277857563 813 dbSNP
rs1176232736 815 dbSNP
rs1349970515 818 dbSNP
rs1205666020 819 dbSNP
rs886297772 822 dbSNP
rs778239438 823 dbSNP
rs1209959991 824 dbSNP
rs988846621 825 dbSNP
rs956161943 827 dbSNP
rs994676166 829 dbSNP
rs1470156124 830 dbSNP
rs201512489 831 dbSNP
rs532247261 831 dbSNP
rs569861397 834 dbSNP
rs867763743 835 dbSNP
rs1222652018 836 dbSNP
rs754602023 836 dbSNP
rs772394688 836 dbSNP
rs1312722574 837 dbSNP
rs1012223154 838 dbSNP
rs386787811 838 dbSNP
rs762211174 838 dbSNP
rs1323698822 839 dbSNP
rs200372958 840 dbSNP
rs895213866 840 dbSNP
rs1311531741 841 dbSNP
rs549700419 842 dbSNP
rs74002777 844 dbSNP
rs368632657 845 dbSNP
rs142285430 846 dbSNP
rs1484079471 846 dbSNP
rs2855370 846 dbSNP
rs374706125 846 dbSNP
rs56279647 846 dbSNP
rs71827510 846 dbSNP
rs79778984 846 dbSNP
rs562044040 847 dbSNP
rs1294591241 848 dbSNP
rs1371941622 848 dbSNP
rs895981838 848 dbSNP
rs946916774 848 dbSNP
rs915509688 849 dbSNP
rs1196159945 850 dbSNP
rs1469733350 850 dbSNP
rs1478326984 850 dbSNP
rs542301182 850 dbSNP
rs528508419 851 dbSNP
rs796836475 851 dbSNP
rs1354487874 852 dbSNP
rs1401656003 852 dbSNP
rs559752557 852 dbSNP
rs940419176 852 dbSNP
rs1314556243 853 dbSNP
rs987659018 853 dbSNP
rs1214307779 854 dbSNP
rs1385472347 854 dbSNP
rs1491271779 854 dbSNP
rs1048729638 855 dbSNP
rs1219312904 855 dbSNP
rs561630495 855 dbSNP
rs879324018 855 dbSNP
rs886213856 855 dbSNP
rs950575369 855 dbSNP
rs1026534165 856 dbSNP
rs1304175748 857 dbSNP
rs1448323908 857 dbSNP
rs570784945 857 dbSNP
rs930324355 858 dbSNP
rs1222749825 859 dbSNP
rs13332377 859 dbSNP
rs111648142 860 dbSNP
rs1278648780 861 dbSNP
rs78282474 861 dbSNP
rs944671596 861 dbSNP
rs1178168657 862 dbSNP
rs1441475300 862 dbSNP
rs1479765725 862 dbSNP
rs1367036961 863 dbSNP
rs1156318445 864 dbSNP
rs1394279685 865 dbSNP
rs1177932432 866 dbSNP
rs1418488339 866 dbSNP
rs1022861481 867 dbSNP
rs1352451539 867 dbSNP
rs1012190291 868 dbSNP
rs928885380 868 dbSNP
rs748318720 869 dbSNP
rs374108045 870 dbSNP
rs895173653 872 dbSNP
rs1056551211 874 dbSNP
rs978764456 876 dbSNP
rs1003996646 878 dbSNP
rs567025319 880 dbSNP
rs1431347885 882 dbSNP
rs1459109429 884 dbSNP
rs1191706545 885 dbSNP
rs1266459512 886 dbSNP
rs902604389 887 dbSNP
rs567880403 888 dbSNP
rs1192763886 893 dbSNP
rs1042551574 894 dbSNP
rs946885769 895 dbSNP
rs563951265 897 dbSNP
rs183689703 898 dbSNP
rs1324604492 899 dbSNP
rs35441076 900 dbSNP
rs763430709 900 dbSNP
rs1039330269 905 dbSNP
rs943040781 906 dbSNP
rs911585648 908 dbSNP
rs987163812 910 dbSNP
rs371125343 912 dbSNP
rs950491593 914 dbSNP
rs919027909 915 dbSNP
rs973194701 917 dbSNP
rs34182480 918 dbSNP
rs1347011333 920 dbSNP
rs1452176020 924 dbSNP
rs368452156 924 dbSNP
rs1240163904 927 dbSNP
rs1477348800 927 dbSNP
rs1194078522 928 dbSNP
rs1398874197 928 dbSNP
rs1474012227 929 dbSNP
rs1162196107 930 dbSNP
rs775937434 931 dbSNP
rs960359165 932 dbSNP
rs1022828927 936 dbSNP
rs1326057934 938 dbSNP
rs1464541497 938 dbSNP
rs1012826356 939 dbSNP
rs1376991469 940 dbSNP
rs554253529 941 dbSNP
rs1004414028 943 dbSNP
rs554255347 944 dbSNP
rs776059099 945 dbSNP
rs1282113142 948 dbSNP
rs1217137451 950 dbSNP
rs994478294 950 dbSNP
rs1265049997 954 dbSNP
rs534381681 958 dbSNP
rs1003558653 959 dbSNP
rs1368565623 961 dbSNP
rs1038735192 963 dbSNP
rs571731180 964 dbSNP
rs902572213 966 dbSNP
rs1299264024 968 dbSNP
rs1362775126 969 dbSNP
rs1333704645 970 dbSNP
rs1394525190 970 dbSNP
rs397514891 970 dbSNP
rs781421943 972 dbSNP
rs1341260303 973 dbSNP
rs558109446 974 dbSNP
rs538964708 976 dbSNP
rs1052857037 977 dbSNP
rs1240696715 977 dbSNP
rs202247051 977 dbSNP
rs894010540 977 dbSNP
rs926002084 978 dbSNP
rs1345407745 979 dbSNP
rs1199556630 982 dbSNP
rs979264685 983 dbSNP
rs1198786097 984 dbSNP
rs1179126511 985 dbSNP
rs970202456 986 dbSNP
rs1483216769 987 dbSNP
rs730882074 989 dbSNP
rs34379884 990 dbSNP
rs1464890960 991 dbSNP
rs960266423 991 dbSNP
rs992866439 991 dbSNP
rs1172335318 992 dbSNP
rs943576288 992 dbSNP
rs1397997360 993 dbSNP
rs150008139 993 dbSNP
rs1376177111 994 dbSNP
rs1311319790 997 dbSNP
rs1447448818 997 dbSNP
rs1345608098 1002 dbSNP
rs34246147 1003 dbSNP
rs1316393843 1004 dbSNP
rs1004345164 1006 dbSNP
rs1346768812 1011 dbSNP
rs1256886891 1013 dbSNP
rs890728712 1013 dbSNP
rs952864367 1013 dbSNP
rs550001058 1014 dbSNP
rs1051844894 1015 dbSNP
rs536065645 1016 dbSNP
rs1319785726 1017 dbSNP
rs918995030 1018 dbSNP
rs567432587 1019 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.743 2.4e-5 0.698 1.1e-4 23 Click to see details
GSE21687 Ependynoma primary tumors 0.375 1.1e-3 0.267 1.6e-2 64 Click to see details
GSE28544 Breast cancer 0.515 5.0e-3 0.625 5.5e-4 24 Click to see details
GSE19783 ER+ ER+ breast cancer 0.2 2.0e-1 0.138 2.8e-1 20 Click to see details
GSE38226 Liver fibrosis 0.159 2.5e-1 0.108 3.2e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.137 2.6e-1 -0.094 3.3e-1 25 Click to see details
GSE19536 Breast cancer 0.053 3.0e-1 0.052 3.0e-1 100 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.098 3.4e-1 0.411 3.6e-2 20 Click to see details
GSE28260 Renal cortex and medulla 0.109 3.6e-1 0.126 3.4e-1 13 Click to see details
GSE17498 Multiple myeloma 0.055 3.7e-1 0.044 3.9e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.057 4.0e-1 0.121 2.9e-1 24 Click to see details
GSE19783 ER- ER- breast cancer -0.017 4.4e-1 -0.042 3.6e-1 79 Click to see details
GSE19350 CNS germ cell tumors 0.048 4.4e-1 0.150 3.2e-1 12 Click to see details
GSE32688 Pancreatic cancer -0.002 5.0e-1 0.026 4.4e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.002 5.0e-1 0.026 4.4e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.596 0 -0.531 0.01 18 Click to see details
LUSC -0.391 0.01 -0.505 0 38 Click to see details
STAD -0.406 0.01 -0.418 0.01 32 Click to see details
KIRC 0.234 0.03 0.075 0.27 68 Click to see details
COAD 0.669 0.03 0.810 0.01 8 Click to see details
PCPG 0.988 0.05 1.000 0.5 3 Click to see details
THCA 0.191 0.07 0.140 0.15 59 Click to see details
KIRP 0.262 0.07 0.312 0.04 32 Click to see details
ESCA -0.408 0.11 -0.382 0.12 11 Click to see details
PAAD -0.764 0.12 -0.800 0.1 4 Click to see details
CESC 0.746 0.23 0.500 0.33 3 Click to see details
KICH -0.126 0.27 -0.175 0.2 25 Click to see details
LUAD 0.16 0.31 0.203 0.26 12 Click to see details
HNSC 0.077 0.31 0.083 0.3 42 Click to see details
LIHC 0.036 0.4 0.110 0.23 49 Click to see details
CHOL 0.08 0.42 0.250 0.26 9 Click to see details
UCEC 0.042 0.43 0.125 0.31 19 Click to see details
BRCA 0.005 0.48 0.089 0.21 84 Click to see details
PRAD 0.005 0.49 0.017 0.45 50 Click to see details
PRAD 0.005 0.49 0.017 0.45 50 Click to see details
PRAD 0.005 0.49 0.017 0.45 50 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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