miRTarBase - #MIRT439975


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pre-miRNA Information
pre-miRNA hsa-mir-544a   
Genomic Coordinates chr14: 101048658 - 101048748
Description Homo sapiens miR-544a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-544a
Sequence 55| AUUCUGCAUUUUUAGCAAGUUC |76
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1286637864 5 dbSNP
rs1394789797 9 dbSNP
rs1172200176 17 dbSNP
Putative Targets

Gene Information
Gene Symbol PIK3C2A   
Synonyms CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha
Description phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Transcript NM_002645   
Expression
Putative miRNA Targets on PIK3C2A
3'UTR of PIK3C2A
(miRNA target sites are highlighted)		 
>PIK3C2A|NM_002645|3'UTR
   1 ACTAGTGAATGTTTGAGCTTTGGAAGCATGAACAGTTATAAACGTGCATGCATACATGCACACACACACAGACACACACA
  81 CACACACTTGTTAATTTTGTATAGTATTTTTATACTTGGACAGAACTTATAAAGTTAAATATACTTGCTGCATTTCAACA
 161 CATCTGTTGGACCAACAGTCACATAACTAACCTTTTTGAATTTTTGGAAGCCATTGCTGTTTTAAAGTCATTATGTAGAA
 241 TGCTACAAACCCTAAACTTAATATATACTAATTCCTGAAAAAGACTTTGAGACAGTACTATGTCAGTTCAGCCACCTATT
 321 TTGCATTGTTTTCTATAAGGAGGCAAAGCATATGTGTTTTCCTGTTATGCACCTTTTATAGCCTTTACCACTGTGTAATG
 401 TTCACAAACACCAAAGTAAAGGAAAAATGCAGGATGTTACCGTAAAATCCAGCTGCTATTCATGGAGCTGAAAAACAAAG
 481 CACAAATAATAGATAGCTAAGTTAAGAACTACTAAGTAGTTTATAGAAGTAGGGAAAAACGTAATACTGCTTTTTATTCA
 561 TGTCTTTAAAGCCTTTTTCAGAATAAGTGCCAATCACTGATGTTGTAAATAATGGTGCCTTAACTTTATATGCTTCCCTG
 641 GCACTTCGTTTCTGATTTTTTTCCTGATTTGATAAATAATTAGTACATAGTTTTCACTCACTTGCAGCTTACTAAAGACA
 721 AGAAATTATGTACATGTACTAATGTTTTTCCCACAAAAAAATCCTTTACTTCTGATGTATGAATTAGTTATCTAAATAGT
 801 TAAGCCTAATACCTGAATAAGACTCACCAATGTGATTGTACAATAAATTCTATCATTCCATTAAAATCCTACATTTATTC
 881 CCAGGAATGGTAATTTCACCTCCCTACATCTATACTCCACTCCCTCAGTAAATAAGTGAAAATTGTTAACCCATGTGCCC
 961 ATTCCTGAGTAGGGCAGACTCTTCACAAGAGGCCCATGACAAGAATTCTAGGGTCCAGATTGAACTTTAATATAGACCTT
1041 TGTCTGTGTAGACCAGTTTGTCTTGTAAACTGTCTTACTTATGTGTGTAAACATTTTACATTCACATGAAAAGTTATTTT
1121 CCTTTATATAATTGGATTCAGAATCATAAGGGACAGGACTGAAATTATTCTACAGTAACCAGTAAGAATAAGATTCGGCC
1201 GGGCACGGTGGCTCCTGCCTGTAATCCCAACACTTTGGGAGGCCAAGGTGGGCGGATCACCTGAGGTCAGGAGTTTGAGA
1281 CCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACACAAAAATTAGCCAGGCGTGGTAGCGGGCATCTGTAATCCCAGCT
1361 ACTTGGGGGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGATCACGCCACTGCACTC
1441 CCGCCTGGGTGACAAGAGCAAAACTCCATCTTAAAAAAAAAGAAAAAAAGAGTAAGATTCATTTTTATTAGTTACTCAAC
1521 TTCAGACACAATTTTGTTAATTTGGATATATACATATATATAATAAGAACTCATGGTTAGAATAGAAATACAGATACTTT
1601 AAAAATGGTAATAGAAATTGTACCAATCAGGTTGCTGTGAGAAAACTGACAAAATATGCAATAAAGAATACCAAGAGAGA
1681 AAGGACAATCGCCAATTCAGTTTCCCAGAACAGAATTTTTATGAACTGCACAAATGTTTAATGTAAATGGTGATACCTAC
1761 AGGGAAGAAATAGAAGAGTTGATAATATATCACTGGGACGGGGTGGGGGAAAGACTTGAAATTTTTGGTGCCTAACACTA
1841 ATGGTCCATATGTAGTTAAACCCATGAGTATGGTATATGAATGTCTTTTTTAAATGTTAAAATGTGTTGTCTATTTAATG
1921 TTAATTAAAATGCAGATCAAAGCACCACCATTTGCTTTTTCCACAGATCATTAACATTTCCTTAAAGTATGTAAGTACCT
2001 TTGCAAATGCAAATGTACTAGTAATTTTCACTTAAGCTTTTGAGACCGAATTCCATTCCACCAGTTATCACTTAGCCACT
2081 GTAATTTAAAAACAAACAAACAAACAAAAACTGTCTTGGTAGAGGTCGTTAATTAGACTCAACATGTACTGCCTTTTTGC
2161 AGTCTATTATGACAGTGTCTTTTAGCACAAATAATAGAGCTAAAAAATGTCCTGTCACTTCCATTATAAGAAATCTGGAT
2241 TCATATCTAAGTGTATATTATAATACTGTACAGTTAAGAGTTCAGAACAAGTGGTAATGTTTTCTCTTAATTTAACTCAT
2321 TTTGTGCCTTCTTTACTCATTCAAACACACATACATTTTACATATAGTTTATTTCTTTATGAAATGCTAATCTTCAGCCC
2401 GTACCAAAAAGTAGAGTGGAGCCTCTTTGCACTACTACTATCAATAAATTTTAAATCAGTTGGATTTTTAAGCATTTTTT
2481 AAAAGCTGACATTAAAGTAAATCTAAAAAAAGTTTAACAAACTGGCCAAGACACTAATTTTTATGTATAATCACAATATT
2561 TTATACTCACCTTTATTGACTAAAAATAATTATGCTACATGTTGTCCTGCATCAGAAGAATTATTTCTTCTTGCCAGTGT
2641 TTTGGGATTTGAAGATAATGGTTCACTCAAAGAACCTATTATTTTCTCTACTGAGGAACCCAATGTAGAACTTGCACTGA
2721 TATTTTTATTACTGCCTTTATATGAATCTATAGGTATCTAAATGTTAAGGCATGTATGATCTTTGATCATTTCTTTTTTC
2801 AAATTAAAGTTGTATAAAAGTTTCAATATCTTGCCTTAAATTAGTTGCCTATTCTTTCTAGGATTCAAATATTGTGACAT
2881 TTAAAAAAGAAAACATTCACTTTTGAAACTTAGACTTCAGATCAAAAAGGACTGAACCCCCACTATCATAATCCATACAT
2961 TCATTTCCATGTTGTTTGACTAGCAGTGCATATATGAATGAATATGGTAATTAATCTTACCTATAAGAACCAAATACTTT
3041 AATTATATTAAGATAGTGAATAAAGATGTATAATATTTTTATTAATACCTTGAATATATTCAGTGGATTGAATGTGACTT
3121 CATAACTGTACTACGATTGTATTAAAATATTTCTGGAATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuugaACGAU---UUUUACGUCUua 5'
               ||:||   ||||||||||  
Target 5' tttaaTGTTAATTAAAATGCAGAtc 3'
 1914 - 1938 149.00 -11.80
2 
miRNA  3' cuugaacgaUUUUUACGUCUUa 5'
                   ||||||||||:| 
Target 5' aagtaaaggAAAAATGCAGGAt 3'
 414 - 435 149.00 -13.00
3 
miRNA  3' cuUGA-ACGAUUUU-----UACGUCUUa 5'
            :|| | :||||:     |||:|||| 
Target 5' ttGCTGTTTTAAAGTCATTATGTAGAAt 3'
 214 - 241 140.00 -10.49
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26989035 3 COSMIC
COSN15654493 13 COSMIC
COSN26989031 33 COSMIC
COSN30709573 52 COSMIC
COSN17241349 71 COSMIC
COSN6996403 73 COSMIC
COSN31481207 75 COSMIC
COSN30179340 82 COSMIC
COSN19749649 86 COSMIC
COSN30521903 107 COSMIC
COSN1129845 141 COSMIC
COSN30514382 161 COSMIC
COSN31524919 198 COSMIC
COSN27245286 628 COSMIC
COSN29344848 888 COSMIC
COSN10082237 1008 COSMIC
COSN21704919 1044 COSMIC
COSN22978659 1048 COSMIC
COSN21082823 1134 COSMIC
COSN16920985 1294 COSMIC
COSN25145469 1513 COSMIC
COSN20108013 1565 COSMIC
COSN21514386 1785 COSMIC
COSN20108010 1919 COSMIC
COSN20108008 2413 COSMIC
COSN23286802 2456 COSMIC
COSN16141223 2737 COSMIC
COSN22473165 2934 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1172785260 4 dbSNP
rs760034166 6 dbSNP
rs1260854105 8 dbSNP
rs751999259 11 dbSNP
rs10832733 13 dbSNP
rs763255339 16 dbSNP
rs769027910 16 dbSNP
rs1243919561 30 dbSNP
rs569686458 35 dbSNP
rs749470322 35 dbSNP
rs1203242909 36 dbSNP
rs376894515 39 dbSNP
rs551705163 43 dbSNP
rs775994151 44 dbSNP
rs1307367158 48 dbSNP
rs768141825 50 dbSNP
rs746526234 51 dbSNP
rs1213993713 52 dbSNP
rs149159222 58 dbSNP
rs936702097 59 dbSNP
rs1313454539 60 dbSNP
rs1176155766 62 dbSNP
rs928383563 63 dbSNP
rs1409289920 69 dbSNP
rs1042978447 71 dbSNP
rs199758636 71 dbSNP
rs903863131 71 dbSNP
rs201587362 73 dbSNP
rs910438647 73 dbSNP
rs1167428613 75 dbSNP
rs948918653 75 dbSNP
rs566279890 81 dbSNP
rs1311242766 86 dbSNP
rs1303945220 88 dbSNP
rs1333954757 88 dbSNP
rs1373886494 88 dbSNP
rs66708666 88 dbSNP
rs71844947 88 dbSNP
rs753880826 88 dbSNP
rs987282655 88 dbSNP
rs933127369 90 dbSNP
rs1381901046 94 dbSNP
rs1232953029 101 dbSNP
rs1334640913 102 dbSNP
rs1454598041 104 dbSNP
rs1186492833 110 dbSNP
rs919007207 113 dbSNP
rs1475718531 119 dbSNP
rs1359823938 121 dbSNP
rs1158651326 130 dbSNP
rs1409615117 135 dbSNP
rs990407725 141 dbSNP
rs957885462 142 dbSNP
rs548104917 143 dbSNP
rs1399236556 144 dbSNP
rs750900343 147 dbSNP
rs1159672810 149 dbSNP
rs1431524864 150 dbSNP
rs1444419928 159 dbSNP
rs963413651 164 dbSNP
rs1354774278 166 dbSNP
rs185284146 172 dbSNP
rs1285743451 175 dbSNP
rs1185968832 176 dbSNP
rs560549719 191 dbSNP
rs1213691547 192 dbSNP
rs1273076817 196 dbSNP
rs562074786 203 dbSNP
rs192983808 209 dbSNP
rs1280186892 213 dbSNP
rs187834222 214 dbSNP
rs1486294940 218 dbSNP
rs1214600724 222 dbSNP
rs955427897 230 dbSNP
rs1029709917 232 dbSNP
rs564568481 233 dbSNP
rs1421700522 235 dbSNP
rs1452612737 240 dbSNP
rs997264596 248 dbSNP
rs147624382 253 dbSNP
rs1014178694 257 dbSNP
rs3802962 258 dbSNP
rs1379969919 263 dbSNP
rs1006119886 265 dbSNP
rs1270374405 285 dbSNP
rs956887768 288 dbSNP
rs553040181 304 dbSNP
rs1288416318 307 dbSNP
rs1231368423 310 dbSNP
rs1302068749 318 dbSNP
rs754232217 324 dbSNP
rs1349227734 325 dbSNP
rs1202767898 333 dbSNP
rs1428855587 335 dbSNP
rs1446825942 342 dbSNP
rs1216993564 350 dbSNP
rs1250081406 354 dbSNP
rs1467320604 354 dbSNP
rs887709299 356 dbSNP
rs540920139 357 dbSNP
rs1395835654 358 dbSNP
rs1454645554 359 dbSNP
rs573561160 364 dbSNP
rs1047399694 368 dbSNP
rs183505079 376 dbSNP
rs139816927 377 dbSNP
rs1165999863 378 dbSNP
rs118169004 379 dbSNP
rs1390307302 399 dbSNP
rs1156272226 408 dbSNP
rs1438344050 412 dbSNP
rs1424945780 418 dbSNP
rs1413844025 429 dbSNP
rs903894314 433 dbSNP
rs1456435765 434 dbSNP
rs1185388181 438 dbSNP
rs1045507373 441 dbSNP
rs948510872 442 dbSNP
rs1236032999 446 dbSNP
rs147419435 452 dbSNP
rs1350615095 458 dbSNP
rs1006820529 459 dbSNP
rs1216896657 461 dbSNP
rs760760600 462 dbSNP
rs1224627737 463 dbSNP
rs539690705 471 dbSNP
rs1467305528 476 dbSNP
rs889032648 497 dbSNP
rs1490125159 499 dbSNP
rs936240751 505 dbSNP
rs1289399016 511 dbSNP
rs1223646834 516 dbSNP
rs775813778 522 dbSNP
rs933182503 535 dbSNP
rs376853075 540 dbSNP
rs919094071 541 dbSNP
rs1413983034 542 dbSNP
rs1459530840 547 dbSNP
rs769472495 557 dbSNP
rs1212820930 566 dbSNP
rs977357645 574 dbSNP
rs955377358 583 dbSNP
rs922642738 587 dbSNP
rs566253138 591 dbSNP
rs771981056 593 dbSNP
rs1335618622 602 dbSNP
rs941746958 624 dbSNP
rs1443639600 636 dbSNP
rs964500917 647 dbSNP
rs867682004 648 dbSNP
rs1160761360 655 dbSNP
rs1279069310 660 dbSNP
rs1404628479 663 dbSNP
rs373318015 663 dbSNP
rs1006480353 672 dbSNP
rs1273995297 680 dbSNP
rs1358760429 680 dbSNP
rs1194086199 684 dbSNP
rs530316434 690 dbSNP
rs1295693976 707 dbSNP
rs1437152232 713 dbSNP
rs969008702 720 dbSNP
rs1253668466 727 dbSNP
rs918208523 735 dbSNP
rs951911134 736 dbSNP
rs1459126283 740 dbSNP
rs191123877 741 dbSNP
rs957118374 743 dbSNP
rs1019105315 745 dbSNP
rs1354143473 760 dbSNP
rs993455123 761 dbSNP
rs771855262 762 dbSNP
rs906862149 768 dbSNP
rs1476516881 769 dbSNP
rs1045450856 777 dbSNP
rs529614912 778 dbSNP
rs774475604 779 dbSNP
rs1193921266 801 dbSNP
rs776086992 802 dbSNP
rs968120266 810 dbSNP
rs1340201396 811 dbSNP
rs568739777 817 dbSNP
rs1018272332 823 dbSNP
rs1484656926 827 dbSNP
rs550211948 834 dbSNP
rs1209802329 837 dbSNP
rs894232606 842 dbSNP
rs1054599010 843 dbSNP
rs1266473912 847 dbSNP
rs760938993 849 dbSNP
rs531714771 850 dbSNP
rs1449497227 851 dbSNP
rs924827071 852 dbSNP
rs1434719470 854 dbSNP
rs564449544 860 dbSNP
rs897681544 878 dbSNP
rs546277367 892 dbSNP
rs1380714705 905 dbSNP
rs533021996 912 dbSNP
rs1327272413 915 dbSNP
rs559134172 917 dbSNP
rs1301343052 918 dbSNP
rs1345633701 921 dbSNP
rs1258852496 945 dbSNP
rs1233549078 947 dbSNP
rs752828249 950 dbSNP
rs1223099989 953 dbSNP
rs1256342717 964 dbSNP
rs1484133347 965 dbSNP
rs1343829404 966 dbSNP
rs1303703431 971 dbSNP
rs975838896 982 dbSNP
rs770388192 984 dbSNP
rs964132232 992 dbSNP
rs1373062758 1013 dbSNP
rs887533921 1017 dbSNP
rs1465073666 1018 dbSNP
rs1189941519 1032 dbSNP
rs1392787781 1032 dbSNP
rs11024153 1036 dbSNP
rs917574715 1037 dbSNP
rs1452019545 1043 dbSNP
rs1288668736 1044 dbSNP
rs777379096 1046 dbSNP
rs1437629791 1047 dbSNP
rs778281616 1048 dbSNP
rs868460230 1048 dbSNP
rs951858880 1054 dbSNP
rs573620095 1063 dbSNP
rs1170825052 1064 dbSNP
rs755964409 1072 dbSNP
rs555208587 1081 dbSNP
rs1301842134 1082 dbSNP
rs1313900893 1084 dbSNP
rs1236532667 1085 dbSNP
rs1260001313 1092 dbSNP
rs1329412042 1095 dbSNP
rs1210266741 1097 dbSNP
rs1250563216 1100 dbSNP
rs992850736 1108 dbSNP
rs1375524696 1134 dbSNP
rs1026187312 1139 dbSNP
rs1417856191 1170 dbSNP
rs543050185 1177 dbSNP
rs1158827602 1179 dbSNP
rs1413234401 1182 dbSNP
rs993403090 1188 dbSNP
rs747686064 1194 dbSNP
rs935612223 1196 dbSNP
rs1433548201 1200 dbSNP
rs112133469 1201 dbSNP
rs780907920 1206 dbSNP
rs1369640264 1207 dbSNP
rs1013008065 1210 dbSNP
rs894188288 1212 dbSNP
rs979624728 1214 dbSNP
rs1246316614 1221 dbSNP
rs1230039481 1227 dbSNP
rs1238746404 1230 dbSNP
rs1033177881 1232 dbSNP
rs999987928 1236 dbSNP
rs1321528330 1238 dbSNP
rs1266766100 1245 dbSNP
rs903352894 1250 dbSNP
rs1041896427 1253 dbSNP
rs1234327784 1254 dbSNP
rs934221662 1255 dbSNP
rs528448784 1260 dbSNP
rs1417345482 1279 dbSNP
rs557606828 1291 dbSNP
rs1406243673 1292 dbSNP
rs985505855 1298 dbSNP
rs1352890555 1305 dbSNP
rs1305381341 1307 dbSNP
rs1307295619 1308 dbSNP
rs1351058546 1308 dbSNP
rs1449617804 1313 dbSNP
rs1291217762 1323 dbSNP
rs901446032 1328 dbSNP
rs955397100 1332 dbSNP
rs113557315 1333 dbSNP
rs942699801 1340 dbSNP
rs565591714 1341 dbSNP
rs984606068 1344 dbSNP
rs1203844901 1355 dbSNP
rs930076487 1357 dbSNP
rs1173950651 1361 dbSNP
rs897759578 1366 dbSNP
rs554428285 1378 dbSNP
rs867924881 1380 dbSNP
rs1209086901 1385 dbSNP
rs1257332578 1386 dbSNP
rs1006091972 1387 dbSNP
rs536020541 1398 dbSNP
rs1417674826 1399 dbSNP
rs971273608 1403 dbSNP
rs1169319748 1404 dbSNP
rs1024648638 1409 dbSNP
rs1371020512 1410 dbSNP
rs991131260 1415 dbSNP
rs1431620598 1419 dbSNP
rs1310831666 1420 dbSNP
rs958611428 1426 dbSNP
rs1032712472 1428 dbSNP
rs568803126 1429 dbSNP
rs1182917938 1436 dbSNP
rs550472158 1437 dbSNP
rs1020381314 1438 dbSNP
rs947775178 1440 dbSNP
rs1226946866 1443 dbSNP
rs1201226750 1456 dbSNP
rs896196845 1461 dbSNP
rs1056154544 1466 dbSNP
rs1278323010 1477 dbSNP
rs1443315336 1478 dbSNP
rs1212715282 1482 dbSNP
rs1240519930 1482 dbSNP
rs1259219251 1482 dbSNP
rs1189294378 1488 dbSNP
rs1242712305 1490 dbSNP
rs537901938 1491 dbSNP
rs1451227973 1492 dbSNP
rs1171726806 1496 dbSNP
rs1424406201 1497 dbSNP
rs1314958047 1498 dbSNP
rs570818130 1517 dbSNP
rs901387600 1534 dbSNP
rs1177981980 1544 dbSNP
rs1343003995 1546 dbSNP
rs924222592 1549 dbSNP
rs552250967 1550 dbSNP
rs1244489993 1552 dbSNP
rs1438119122 1553 dbSNP
rs1274732940 1554 dbSNP
rs1346348791 1559 dbSNP
rs139720702 1570 dbSNP
rs561598595 1570 dbSNP
rs751507978 1570 dbSNP
rs1282682219 1579 dbSNP
rs1335668345 1583 dbSNP
rs1328736806 1585 dbSNP
rs1209646121 1589 dbSNP
rs1040359699 1594 dbSNP
rs1467158358 1605 dbSNP
rs1396136648 1606 dbSNP
rs1245996293 1618 dbSNP
rs1478317534 1619 dbSNP
rs1174101245 1624 dbSNP
rs139446328 1626 dbSNP
rs1456352251 1627 dbSNP
rs1159393114 1630 dbSNP
rs1295975065 1636 dbSNP
rs888434457 1651 dbSNP
rs1459366324 1655 dbSNP
rs1322313841 1657 dbSNP
rs946923829 1675 dbSNP
rs1439294941 1681 dbSNP
rs560186545 1681 dbSNP
rs375951665 1682 dbSNP
rs1048416609 1683 dbSNP
rs1278122300 1684 dbSNP
rs911371736 1685 dbSNP
rs930019318 1686 dbSNP
rs1229427508 1687 dbSNP
rs1270189992 1688 dbSNP
rs774411369 1690 dbSNP
rs368108174 1691 dbSNP
rs949864622 1695 dbSNP
rs1452094299 1702 dbSNP
rs547206211 1703 dbSNP
rs991805561 1717 dbSNP
rs1249569112 1727 dbSNP
rs529040077 1731 dbSNP
rs779064147 1742 dbSNP
rs1413633633 1749 dbSNP
rs1030136707 1756 dbSNP
rs1370241359 1766 dbSNP
rs1390886661 1771 dbSNP
rs1033072997 1778 dbSNP
rs978411818 1782 dbSNP
rs1407542606 1783 dbSNP
rs967067622 1787 dbSNP
rs558743525 1789 dbSNP
rs1428021662 1797 dbSNP
rs540635462 1799 dbSNP
rs1290602818 1800 dbSNP
rs1353790862 1804 dbSNP
rs1014883544 1812 dbSNP
rs1006124627 1832 dbSNP
rs1358511097 1835 dbSNP
rs1194173325 1840 dbSNP
rs965923001 1843 dbSNP
rs368265219 1845 dbSNP
rs757817392 1848 dbSNP
rs371907668 1851 dbSNP
rs116155100 1856 dbSNP
rs1205609462 1868 dbSNP
rs1253785976 1870 dbSNP
rs543691608 1873 dbSNP
rs576216309 1875 dbSNP
rs1012065756 1876 dbSNP
rs1186446579 1881 dbSNP
rs896241983 1883 dbSNP
rs1473463555 1885 dbSNP
rs371383902 1886 dbSNP
rs1390028310 1887 dbSNP
rs999231365 1889 dbSNP
rs1310224690 1899 dbSNP
rs1291564718 1913 dbSNP
rs1208539854 1918 dbSNP
rs182072936 1919 dbSNP
rs72565110 1919 dbSNP
rs34206141 1920 dbSNP
rs1225249851 1931 dbSNP
rs1297050034 1932 dbSNP
rs1341357628 1936 dbSNP
rs994176204 1949 dbSNP
rs1276471789 1951 dbSNP
rs1482128655 1958 dbSNP
rs897203549 1962 dbSNP
rs141699063 1966 dbSNP
rs545453659 1979 dbSNP
rs1186116420 1980 dbSNP
rs186629621 1981 dbSNP
rs1049903413 1989 dbSNP
rs934113183 1990 dbSNP
rs1465805345 1998 dbSNP
rs553885062 2003 dbSNP
rs536082224 2005 dbSNP
rs1404619942 2008 dbSNP
rs139187006 2009 dbSNP
rs1360903722 2024 dbSNP
rs1319948987 2031 dbSNP
rs1366078963 2034 dbSNP
rs1055654977 2036 dbSNP
rs1437402478 2037 dbSNP
rs78992617 2042 dbSNP
rs1299664764 2047 dbSNP
rs937226979 2048 dbSNP
rs1232171131 2051 dbSNP
rs1403433320 2058 dbSNP
rs1392735690 2067 dbSNP
rs925900517 2068 dbSNP
rs978359547 2069 dbSNP
rs182582486 2073 dbSNP
rs1321518146 2087 dbSNP
rs967015251 2106 dbSNP
rs766602513 2109 dbSNP
rs909872160 2109 dbSNP
rs951962970 2109 dbSNP
rs1313829277 2111 dbSNP
rs1200014242 2116 dbSNP
rs1379784067 2127 dbSNP
rs191406880 2128 dbSNP
rs1196084981 2136 dbSNP
rs1158651221 2144 dbSNP
rs1389686527 2145 dbSNP
rs751466373 2151 dbSNP
rs976459384 2154 dbSNP
rs35328014 2159 dbSNP
rs1458832196 2162 dbSNP
rs770740249 2170 dbSNP
rs1365399342 2173 dbSNP
rs1268480492 2174 dbSNP
rs1012096503 2187 dbSNP
rs1226371291 2194 dbSNP
rs538541926 2201 dbSNP
rs1197140787 2205 dbSNP
rs1267035797 2214 dbSNP
rs879779651 2221 dbSNP
rs1210053210 2226 dbSNP
rs960812150 2258 dbSNP
rs550172880 2263 dbSNP
rs999662570 2263 dbSNP
rs1291133402 2267 dbSNP
rs1195796749 2286 dbSNP
rs544023034 2292 dbSNP
rs1181922247 2297 dbSNP
rs1412884791 2309 dbSNP
rs1473731649 2316 dbSNP
rs1162755274 2318 dbSNP
rs1349421310 2329 dbSNP
rs1457315018 2330 dbSNP
rs1255661275 2334 dbSNP
rs1293999616 2338 dbSNP
rs1220055253 2352 dbSNP
rs1340707391 2355 dbSNP
rs1287562545 2357 dbSNP
rs764028788 2360 dbSNP
rs1007069826 2362 dbSNP
rs953040396 2369 dbSNP
rs1320554013 2375 dbSNP
rs1027241909 2380 dbSNP
rs994459310 2384 dbSNP
rs1332616288 2389 dbSNP
rs897150605 2393 dbSNP
rs1046461006 2400 dbSNP
rs1014068945 2401 dbSNP
rs895250296 2403 dbSNP
rs1172851676 2410 dbSNP
rs201203529 2414 dbSNP
rs1466227628 2416 dbSNP
rs3217107 2417 dbSNP
rs397840340 2417 dbSNP
rs1484146263 2418 dbSNP
rs1171040059 2420 dbSNP
rs1180376873 2426 dbSNP
rs890038818 2432 dbSNP
rs1056000961 2434 dbSNP
rs1479205882 2437 dbSNP
rs1247715491 2441 dbSNP
rs1167007528 2447 dbSNP
rs1049958852 2456 dbSNP
rs1427806175 2457 dbSNP
rs761107854 2463 dbSNP
rs1370986782 2480 dbSNP
rs1444153569 2487 dbSNP
rs571013154 2488 dbSNP
rs925828864 2490 dbSNP
rs1378004182 2492 dbSNP
rs552565731 2499 dbSNP
rs1316615796 2500 dbSNP
rs1037149549 2502 dbSNP
rs1228373876 2502 dbSNP
rs1275758113 2505 dbSNP
rs940115439 2509 dbSNP
rs1208489473 2512 dbSNP
rs1483741009 2519 dbSNP
rs764905952 2519 dbSNP
rs1183658237 2523 dbSNP
rs945997416 2525 dbSNP
rs1318038665 2526 dbSNP
rs1318022903 2530 dbSNP
rs909947259 2531 dbSNP
rs1167845500 2533 dbSNP
rs984127056 2535 dbSNP
rs970014843 2544 dbSNP
rs912883534 2545 dbSNP
rs533906664 2556 dbSNP
rs566659147 2566 dbSNP
rs34061448 2575 dbSNP
rs976408481 2576 dbSNP
rs943754115 2581 dbSNP
rs1433754024 2591 dbSNP
rs1298924569 2595 dbSNP
rs1342093746 2627 dbSNP
rs1217830448 2630 dbSNP
rs991140189 2633 dbSNP
rs1275261226 2635 dbSNP
rs1205860337 2636 dbSNP
rs1266507788 2637 dbSNP
rs910979930 2638 dbSNP
rs1464463461 2654 dbSNP
rs1189314330 2660 dbSNP
rs575161600 2672 dbSNP
rs985991215 2675 dbSNP
rs960593752 2676 dbSNP
rs1189232384 2686 dbSNP
rs1424259274 2691 dbSNP
rs1374502445 2692 dbSNP
rs775519655 2699 dbSNP
rs1178092543 2711 dbSNP
rs1027189525 2717 dbSNP
rs1456194430 2728 dbSNP
rs1320722153 2732 dbSNP
rs548255605 2735 dbSNP
rs999336091 2736 dbSNP
rs1405524747 2747 dbSNP
rs972965648 2750 dbSNP
rs1332422301 2753 dbSNP
rs1368703488 2754 dbSNP
rs11540752 2763 dbSNP
rs1225762289 2773 dbSNP
rs961646515 2774 dbSNP
rs370222104 2784 dbSNP
rs1328764061 2786 dbSNP
rs966451331 2807 dbSNP
rs1426274432 2808 dbSNP
rs1013596847 2809 dbSNP
rs1010536608 2823 dbSNP
rs867008724 2829 dbSNP
rs1246083459 2830 dbSNP
rs536577637 2843 dbSNP
rs1438254293 2844 dbSNP
rs1382645959 2850 dbSNP
rs889447427 2851 dbSNP
rs1033767370 2854 dbSNP
rs1159235399 2855 dbSNP
rs1403132322 2858 dbSNP
rs1323423678 2861 dbSNP
rs1028555850 2868 dbSNP
rs1457820993 2871 dbSNP
rs1306634299 2872 dbSNP
rs569028179 2872 dbSNP
rs1229293443 2879 dbSNP
rs1281318907 2889 dbSNP
rs1001392807 2911 dbSNP
rs1227829490 2915 dbSNP
rs557133365 2918 dbSNP
rs1490494309 2921 dbSNP
rs998831760 2924 dbSNP
rs1443742575 2939 dbSNP
rs1278914666 2945 dbSNP
rs1042896277 2948 dbSNP
rs1351242021 2955 dbSNP
rs945946932 2958 dbSNP
rs1311362663 2978 dbSNP
rs1182035515 2986 dbSNP
rs891729928 3004 dbSNP
rs1240858249 3014 dbSNP
rs1162138384 3016 dbSNP
rs1386409319 3017 dbSNP
rs1037625716 3020 dbSNP
rs1306533060 3021 dbSNP
rs538411684 3023 dbSNP
rs1370373832 3025 dbSNP
rs940166952 3028 dbSNP
rs1041073263 3031 dbSNP
rs888542275 3037 dbSNP
rs1048504234 3051 dbSNP
rs776212703 3052 dbSNP
rs1317928161 3053 dbSNP
rs1248135690 3054 dbSNP
rs1272431833 3059 dbSNP
rs1418187872 3068 dbSNP
rs943718126 3070 dbSNP
rs1159771060 3072 dbSNP
rs760163716 3076 dbSNP
rs767769383 3078 dbSNP
rs990779600 3083 dbSNP
rs1444601428 3096 dbSNP
rs985217358 3097 dbSNP
rs931078395 3106 dbSNP
rs1186203504 3121 dbSNP
rs34014906 3125 dbSNP
rs939276925 3126 dbSNP
rs1412301258 3131 dbSNP
rs759824023 3134 dbSNP
rs1390124337 3138 dbSNP
rs972914971 3139 dbSNP
rs961592118 3142 dbSNP
rs769471997 3146 dbSNP
rs764328348 3147 dbSNP
rs1400329588 3150 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
139 hsa-miR-544a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT053511 BMI1 BMI1 proto-oncogene, polycomb ring finger 4 1
MIRT054802 CDH1 cadherin 1 3 2
MIRT075814 ZCCHC14 zinc finger CCHC-type containing 14 2 3
MIRT125570 SCD stearoyl-CoA desaturase 1 1
MIRT246745 SF1 splicing factor 1 2 2
MIRT259487 TXLNG taxilin gamma 2 2
MIRT307650 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 2 2
MIRT377046 ASXL2 additional sex combs like 2, transcriptional regulator 2 2
MIRT386936 STAT3 signal transducer and activator of transcription 3 3 1
MIRT394127 UBQLN1 ubiquilin 1 1 1
MIRT439199 ZNF483 zinc finger protein 483 1 1
MIRT439207 ZNF33A zinc finger protein 33A 1 1
MIRT439262 ZBTB17 zinc finger and BTB domain containing 17 1 1
MIRT439263 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 1 1
MIRT439281 XAB2 XPA binding protein 2 1 1
MIRT439314 VAT1 vesicle amine transport 1 1 1
MIRT439380 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439397 TPT1 tumor protein, translationally-controlled 1 1 1
MIRT439419 TMOD1 tropomodulin 1 1 1
MIRT439491 SYT5 synaptotagmin 5 1 1
MIRT439511 STXBP1 syntaxin binding protein 1 1 1
MIRT439586 SMAD7 SMAD family member 7 1 1
MIRT439727 RPS6 ribosomal protein S6 1 1
MIRT439768 RLIM ring finger protein, LIM domain interacting 1 1
MIRT439828 RAD50 RAD50 double strand break repair protein 1 1
MIRT439840 RAB21 RAB21, member RAS oncogene family 1 1
MIRT439846 RAB14 RAB14, member RAS oncogene family 1 1
MIRT439975 PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha 1 1
MIRT440031 PCDHAC2 protocadherin alpha subfamily C, 2 1 1
MIRT440135 NCOA2 nuclear receptor coactivator 2 1 1
MIRT440173 MTSS1L MTSS1L, I-BAR domain containing 1 1
MIRT440222 MMP2 matrix metallopeptidase 2 1 1
MIRT440433 IQGAP1 IQ motif containing GTPase activating protein 1 1 1
MIRT440443 INTS3 integrator complex subunit 3 1 1
MIRT440449 INS insulin 1 1
MIRT440512 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440534 GPR56 adhesion G protein-coupled receptor G1 1 1
MIRT440540 GOLGB1 golgin B1 1 1
MIRT440580 GEM GTP binding protein overexpressed in skeletal muscle 1 1
MIRT440629 FNDC3A fibronectin type III domain containing 3A 1 1
MIRT440667 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440680 CCSER1 coiled-coil serine rich protein 1 1 1
MIRT440696 FADS1 fatty acid desaturase 1 1 1
MIRT440761 DYNC1H1 dynein cytoplasmic 1 heavy chain 1 1 1
MIRT440764 DUSP26 dual specificity phosphatase 26 1 1
MIRT440769 DSTYK dual serine/threonine and tyrosine protein kinase 1 1
MIRT440774 DSP desmoplakin 1 1
MIRT440792 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 1 1
MIRT440801 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 1 1
MIRT440888 CPE carboxypeptidase E 1 1
MIRT440923 CLTC clathrin heavy chain 1 1
MIRT440950 CHD7 chromodomain helicase DNA binding protein 7 1 1
MIRT440993 CC2D2A coiled-coil and C2 domain containing 2A 1 1
MIRT441014 CAPN3 calpain 3 1 1
MIRT441106 BRD4 bromodomain containing 4 1 1
MIRT441144 ATP6V1B2 ATPase H+ transporting V1 subunit B2 1 1
MIRT441173 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT441258 ADM adrenomedullin 1 1
MIRT441279 ACTB actin beta 2 5
MIRT441298 ACACB acetyl-CoA carboxylase beta 1 1
MIRT443751 SLC7A14 solute carrier family 7 member 14 2 2
MIRT450469 TRMT5 tRNA methyltransferase 5 2 4
MIRT450852 HMGN2 high mobility group nucleosomal binding domain 2 2 6
MIRT454152 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT465705 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT466121 TMEM170A transmembrane protein 170A 2 2
MIRT471376 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT477475 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT481660 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT502469 FAM98A family with sequence similarity 98 member A 2 8
MIRT503952 ZNF180 zinc finger protein 180 2 6
MIRT505585 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 6
MIRT529936 SYNGR1 synaptogyrin 1 2 2
MIRT530626 PPIC peptidylprolyl isomerase C 2 4
MIRT536883 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT546847 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT548448 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT557130 HOXA13 homeobox A13 2 2
MIRT560089 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT560984 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT566340 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT567838 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT609236 SERPINA4 serpin family A member 4 2 2
MIRT611452 ZWILCH zwilch kinetochore protein 2 2
MIRT612058 PDGFRA platelet derived growth factor receptor alpha 2 2
MIRT612783 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT615116 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT616572 C1orf56 chromosome 1 open reading frame 56 2 2
MIRT616690 LPL lipoprotein lipase 2 2
MIRT616986 COL19A1 collagen type XIX alpha 1 chain 2 2
MIRT619427 CYB5R3 cytochrome b5 reductase 3 2 2
MIRT623320 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT626897 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT637554 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT639473 SLC6A4 solute carrier family 6 member 4 2 2
MIRT639753 GPR45 G protein-coupled receptor 45 2 2
MIRT640703 MRS2 MRS2, magnesium transporter 2 2
MIRT642489 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT644578 SPOP speckle type BTB/POZ protein 2 2
MIRT645009 NGRN neugrin, neurite outgrowth associated 2 2
MIRT646533 KLK2 kallikrein related peptidase 2 2 2
MIRT648625 LEMD2 LEM domain containing 2 2 2
MIRT650235 ERI1 exoribonuclease 1 2 2
MIRT651932 UBN1 ubinuclein 1 2 2
MIRT652960 SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 2 2
MIRT654842 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT656142 MSH5 mutS homolog 5 2 2
MIRT656730 LMBRD2 LMBR1 domain containing 2 2 2
MIRT657340 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT658991 DLGAP2 DLG associated protein 2 2 2
MIRT660714 AMER1 APC membrane recruitment protein 1 2 2
MIRT666591 RFX3 regulatory factor X3 2 2
MIRT667201 NKX2-3 NK2 homeobox 3 2 2
MIRT668732 DIO2 iodothyronine deiodinase 2 2 2
MIRT669479 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT681083 GSTO2 glutathione S-transferase omega 2 2 2
MIRT686736 STX16 syntaxin 16 2 2
MIRT687432 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT689887 SOD2 superoxide dismutase 2 2 2
MIRT695759 WDR35 WD repeat domain 35 2 2
MIRT698346 TMEM127 transmembrane protein 127 2 2
MIRT702752 IGF1R insulin like growth factor 1 receptor 2 2
MIRT703137 GPR137C G protein-coupled receptor 137C 2 2
MIRT705063 C4orf32 family with sequence similarity 241 member A 2 2
MIRT709597 IFT74 intraflagellar transport 74 2 2
MIRT709997 TXNDC12 thioredoxin domain containing 12 2 2
MIRT710463 ASTN2 astrotactin 2 2 2
MIRT710468 CDH5 cadherin 5 2 2
MIRT715625 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720091 SPTLC3 serine palmitoyltransferase long chain base subunit 3 2 2
MIRT721054 DCC DCC netrin 1 receptor 2 2
MIRT721961 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT722122 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT722538 AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 2 2
MIRT723325 DGAT1 diacylglycerol O-acyltransferase 1 2 2
MIRT725330 NEUROD1 neuronal differentiation 1 2 2
MIRT731556 HOXA10 homeobox A10 2 1
MIRT732380 BCL6 B-cell CLL/lymphoma 6 3 1
MIRT736700 E2F5 E2F transcription factor 5 3 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-544a Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Squamous Cell Carcinoma cell line (KYSE450, TE-1)
hsa-miR-544a Trastuzumab sensitive High Breast Cancer cell line (SKBR3)
hsa-mir-544a Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-544a Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-544a Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-544a Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-544a Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-544a Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-544a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-544a Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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