miRTarBase - #MIRT440017


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pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PCSK1   
Synonyms BMIQ12, NEC1, PC1, PC3, SPC3
Description proprotein convertase subtilisin/kexin type 1
Transcript NM_000439   
Other Transcripts NM_001177875   
Expression
Putative miRNA Targets on PCSK1
3'UTR of PCSK1
(miRNA target sites are highlighted)		 
>PCSK1|NM_000439|3'UTR
   1 AATAAGTGTGTGGTCCCAAGTTGGAAATATTCATGCTTCTTCCTTACCCTGCGATTTTGCCTGTGTCTGAAGTGGTTGTT
  81 TTGTCATGAATTCTTATGCTTATAATATCCTTTGTGGCACCTTTTCTTTTTCTCCCTAAACTGTACATGTGAAGGGGATG
 161 AGCTCAAGCAGGAAGTTCAACTTCCAGAATTGATCATAGGTATTTCAAAACACATCTTTCCTGTCTGCACAAGTGAAGTG
 241 TTTTGTTCTTTCTGGAGTCACAGTTGACAAAAAGCTCTTACACTACATTAGAACACTGCATTAGAGCCCATTTCAATTCT
 321 CAAAAGAAAAGGCAAAACCTGGGATATCAATTAATTTGAAAACATAATCTGCAAAGAATGAGAAGGAGTCAGAAACTGTT
 401 TCTGTAGCTTGTTCCCTGTCTTGTCCATGTGGTTCTTCAAATTTTGATGCCAAGAAAGTATTTGGTAGGCCTAATGAAGG
 481 AGTTCACTGTAAGACTCATTCCCTAGATCTTTCTATTCCAAAGTGCCACTCATTCCTGTAGTCAAAATCTGGTCATGTTG
 561 GTCAAAAGCTGGATTATTTAGATCTAGAAACAGATCTTGAAATCTGAATGCTCTGGTTTGAGCAATTTTCGAACATTCTT
 641 TGCCTGGTGCACTGTGTCTGTGGTGCCAGAGGCGTCCGTGGATCCAGAGGTGGTTATGACTCGTGCTGCATGCCTGGTCT
 721 TTCCTCTGTTTCTCCTTCTGAAAGTTTTCTATACCTGTCTCCTTTCTCAGCCACAAAATAAATGTTGGGAGAAATGATAT
 801 ATACCACTTTCCCAGAAAAAAAAAAACTTACACTTGGGACTTGGCAAATTCCTAGTCACAATTTTTTTCAGCAGTAACAG
 881 GAAACCACTTATCACATGGAGACCTAATGTAATAATAGAAAAATACTCATAATAGGGAGAAACCAAGAGAAGTTTTGTTT
 961 TTGTTTTTTTCCAACTGTGTTCATTAGAACAGCGTGTTCTAAGTATTTGAAACTGAATGTTTATTCCTTGATACTAAAAG
1041 TTCTTCTCCAATCCTATCACTGATAGTGTCCAAATTCTCACCAAATTGCTCCTAAGCTTCAAATCAGAAGCAGAAACTGG
1121 CAGGCCATGGACCTTAATTGTCCCTCAGGTAGATTTTGTTTGGTATGCAGAATGTTTTTAAAATATGAGTGGTTATTGAA
1201 AATATGATGTTTCACATAAAACCTCATTCTCGGACCCATCTTTGCTCATGGCAACAGTTAGCTGGAGCTGAGTAGCAGCT
1281 GCCTGATTAGATGACTCTCAGTCCCCATGGCACCCTGCTCCATGTTACCTAGAGCAGGCACTTGATTCCTTGCTGGGCAG
1361 TATCCAATAGGCATTTGATTTTGCCCACTCCTACACTAAGCGAATGTGTACAAAGTGTAAATGCATTAGGAAAAACAAAC
1441 TACCCGCATCTTCTGTTAGGCAGGATCTGTACAATAATAATTATGAGTTTGCTTATGTAATCTCACCTCACCTGGATGAT
1521 CACTAATACTAATTCATTTATTACTAACCTTCTGGCTTCCTTCTCTCAATATGCTTACAAAGTCTCCAGTCACCTACAAT
1601 GCTGGCTTTCTCCCACTGAGTTTGCTGTTTGCAATTTTTCCATGAAGTTTGAACTTCATAAGGTAATTCATGGCATTGAA
1681 CTGGTTCATGAAAAGAACACTAGAGTCTGTCATTTGCTTTGGCTTGAAGTATGGTTGGTAACACAAATTTTCACCTGCTC
1761 TTCTACCATTTGAATTTGTGTAGAGGGTGTTTGCAGAGCAATGCCCGTAATGCTTAGAGAATGTTCTCCTAAAAGACTTG
1841 CGGAATCACTCTGTCCTTGGAAGTTTCATATATTGTTTGATATGAAGTGTTAGATAGAATTTCCAATATTGGAGCATATC
1921 AAAAAGTATTAAAACTAAAAAGGACCAGAGAATTCTTAGATTGGCCCGGAAAGGCCAATAAAGAGTTAGAATGAAAACTC
2001 ATTACTTTTCCATTCCCAATCTAGTGCTAGATGTATAAATCTTTCTTTTGATTCTTCCTAACAAAATATTTTCTGGGTTA
2081 AAACCCCAGCCAACTCATTGGGTTGTAGCCAAAGGTTCACTCTCAAGAAGCTTTAATATTTAAATAAAATCATATTGAAT
2161 GTTTCCAACCTGGAGTATAATATTCAGATATAAAACAGTTTTGTCAGTCTTTCTTAGTGCCTGTGTGGATTTTTGTGAAA
2241 ATGTCAAAGAGAAAACTTATATACTATTTCCCTTGAAATTTTAAACTATATTTTCTTTACAGGTATTTATAATATACCAA
2321 TGCTTTTATCAAACAGAATTTTAAAGAGCATAATAAATTATATTAAAGAACCAAAAGTTTTCCTGAGAATAAGAAAGTTT
2401 CACCCAATAAAATATTTTTGAAAGGCATGTTCCTCTGTCAATGAAAAAAAGTACATGTATGTGTTGTGATATTAAAAGTG
2481 ACATTTGTCTAATAGCCTAATACAACATGTAGCTGAGTTTAACATGTGTGGTCTTGGTATTCTTAAGGGAACTTCCACAT
2561 TATACATTTGATGTATTGACCAGAATATGTAAAATATGCTTATAAATCAGAAAAATAAATTGTTTCTCACTAAGTCAAAA
2641 GAAAAAAAGCTCATGTTTCCACCAC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uauucucAGAGGGG---GACAUAUa 5'
                 ||||||:   ||||| | 
Target 5' ttcttttTCTCCCTAAACTGTACAt 3'
 124 - 148 127.00 -12.60
2 
miRNA  3' uauucUCAGAGGG------GGACAUAUa 5'
               |||||::|      |||||:|: 
Target 5' ttgtcAGTCTTTCTTAGTGCCTGTGTGg 3'
 2201 - 2228 127.00 -15.90
3 
miRNA  3' uaUUCUCAGAGGG---GGACAUaua 5'
            ||| | | |:|   ||||||   
Target 5' caAAGTGCCACTCATTCCTGTAgtc 3'
 519 - 543 120.00 -11.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
354636 88 ClinVar
905290 120 ClinVar
905289 170 ClinVar
905288 245 ClinVar
354635 263 ClinVar
354634 265 ClinVar
354633 287 ClinVar
904501 438 ClinVar
354632 471 ClinVar
354631 597 ClinVar
354630 740 ClinVar
354629 827 ClinVar
354628 837 ClinVar
354627 905 ClinVar
907816 974 ClinVar
354626 1041 ClinVar
354625 1097 ClinVar
907815 1132 ClinVar
354624 1164 ClinVar
354623 1231 ClinVar
354622 1232 ClinVar
906825 1307 ClinVar
354621 1333 ClinVar
906824 1372 ClinVar
354620 1401 ClinVar
354619 1414 ClinVar
354618 1443 ClinVar
354617 1530 ClinVar
354616 1571 ClinVar
354615 1733 ClinVar
354614 1842 ClinVar
354613 1854 ClinVar
354612 1912 ClinVar
904442 1967 ClinVar
354611 2019 ClinVar
907770 2115 ClinVar
354610 2166 ClinVar
907769 2187 ClinVar
354609 2288 ClinVar
907768 2582 ClinVar
907767 2611 ClinVar
907766 2634 ClinVar
907765 2636 ClinVar
COSN30134468 7 COSMIC
COSN31502276 12 COSMIC
COSN26988277 13 COSMIC
COSN30189495 17 COSMIC
COSN30486852 32 COSMIC
COSN31507067 35 COSMIC
COSN14185295 42 COSMIC
COSN30136013 53 COSMIC
COSN30157404 63 COSMIC
COSN30485876 88 COSMIC
COSN31525009 93 COSMIC
COSN26988276 99 COSMIC
COSN30115017 99 COSMIC
COSN31500397 103 COSMIC
COSN30471219 109 COSMIC
COSN30121441 117 COSMIC
COSN30480605 134 COSMIC
COSN30508286 142 COSMIC
COSN30469811 155 COSMIC
COSN30132293 156 COSMIC
COSN31601447 170 COSMIC
COSN30481022 172 COSMIC
COSN31600837 199 COSMIC
COSN6715656 251 COSMIC
COSN14833688 265 COSMIC
COSN30544270 333 COSMIC
COSN8493295 426 COSMIC
COSN31582992 454 COSMIC
COSN20101544 734 COSMIC
COSN18723477 816 COSMIC
COSN20101541 816 COSMIC
COSN7587962 1845 COSMIC
COSN26784265 1867 COSMIC
COSN31484735 1976 COSMIC
COSN201777 2021 COSMIC
COSN30108941 2041 COSMIC
COSN31607770 2114 COSMIC
COSN30176899 2122 COSMIC
COSN30165475 2245 COSMIC
COSN30086460 2308 COSMIC
COSN31546636 2317 COSMIC
COSN17979161 2523 COSMIC
COSN23967587 2572 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1360244595 3 dbSNP
rs200901773 7 dbSNP
rs1190276542 12 dbSNP
rs1468500670 13 dbSNP
rs751099712 15 dbSNP
rs763429283 21 dbSNP
rs1404609208 24 dbSNP
rs775919898 27 dbSNP
rs376269033 30 dbSNP
rs1240298354 31 dbSNP
rs759783710 33 dbSNP
rs373029530 36 dbSNP
rs1440469687 37 dbSNP
rs1371764895 41 dbSNP
rs369706934 49 dbSNP
rs980104968 66 dbSNP
rs1383211794 67 dbSNP
rs1324158676 69 dbSNP
rs902734649 83 dbSNP
rs1365512788 85 dbSNP
rs886060886 88 dbSNP
rs112555054 92 dbSNP
rs1460670800 98 dbSNP
rs1188993694 99 dbSNP
rs1243425611 106 dbSNP
rs111754221 107 dbSNP
rs1185415251 114 dbSNP
rs915412736 120 dbSNP
rs974500043 121 dbSNP
rs1481686289 122 dbSNP
rs3190961 126 dbSNP
rs1174848446 127 dbSNP
rs1406020645 137 dbSNP
rs1426975042 142 dbSNP
rs191568835 147 dbSNP
rs1018775107 151 dbSNP
rs146418909 158 dbSNP
rs987172310 162 dbSNP
rs1347429511 167 dbSNP
rs950364201 170 dbSNP
rs1026200333 180 dbSNP
rs1205502685 181 dbSNP
rs1286151629 190 dbSNP
rs1194697679 199 dbSNP
rs1447468003 201 dbSNP
rs769155211 208 dbSNP
rs995167378 210 dbSNP
rs1268121504 224 dbSNP
rs1219946799 228 dbSNP
rs375371593 233 dbSNP
rs1429121199 234 dbSNP
rs1473243141 238 dbSNP
rs1160635619 253 dbSNP
rs1406292681 255 dbSNP
rs886060885 263 dbSNP
rs1324393577 264 dbSNP
rs3811942 265 dbSNP
rs144012217 275 dbSNP
rs373041583 287 dbSNP
rs1012328059 291 dbSNP
rs1344793358 293 dbSNP
rs1239736742 304 dbSNP
rs895273825 307 dbSNP
rs1281036808 308 dbSNP
rs1348223722 309 dbSNP
rs73772388 316 dbSNP
rs895594125 322 dbSNP
rs1003465683 330 dbSNP
rs1366657381 332 dbSNP
rs1267625631 339 dbSNP
rs902537012 343 dbSNP
rs567875247 345 dbSNP
rs1042593585 346 dbSNP
rs1164206224 348 dbSNP
rs946981831 352 dbSNP
rs1387312734 355 dbSNP
rs902688239 359 dbSNP
rs1162980791 361 dbSNP
rs1371283971 362 dbSNP
rs1393915398 363 dbSNP
rs1330749776 365 dbSNP
rs1169089847 370 dbSNP
rs1441122437 372 dbSNP
rs1315550572 376 dbSNP
rs1477888909 379 dbSNP
rs1243368613 384 dbSNP
rs375708646 385 dbSNP
rs946996499 386 dbSNP
rs575699116 399 dbSNP
rs1039644125 401 dbSNP
rs1481287734 406 dbSNP
rs555664405 414 dbSNP
rs1203565122 419 dbSNP
rs1184582772 425 dbSNP
rs1245411608 433 dbSNP
rs750185441 438 dbSNP
rs944752869 448 dbSNP
rs1373878315 451 dbSNP
rs886060884 471 dbSNP
rs537616182 475 dbSNP
rs1281928883 479 dbSNP
rs879256544 489 dbSNP
rs1384675169 491 dbSNP
rs928926116 493 dbSNP
rs1346698251 503 dbSNP
rs1295288212 504 dbSNP
rs1450211184 515 dbSNP
rs1313849841 516 dbSNP
rs1326663688 522 dbSNP
rs1279293242 523 dbSNP
rs1027941498 532 dbSNP
rs973336664 535 dbSNP
rs1204900862 549 dbSNP
rs1265572065 557 dbSNP
rs1460219605 559 dbSNP
rs918950357 561 dbSNP
rs1203444012 582 dbSNP
rs1262608725 590 dbSNP
rs973331563 593 dbSNP
rs1022612325 595 dbSNP
rs115434587 597 dbSNP
rs1404795846 599 dbSNP
rs1480822818 600 dbSNP
rs1177011715 601 dbSNP
rs551861593 603 dbSNP
rs116231753 605 dbSNP
rs1467978587 613 dbSNP
rs1425827352 615 dbSNP
rs1031347862 622 dbSNP
rs991694590 630 dbSNP
rs959875579 631 dbSNP
rs1234789198 636 dbSNP
rs566079021 636 dbSNP
rs547743961 648 dbSNP
rs1325307392 660 dbSNP
rs1223612386 665 dbSNP
rs780302380 672 dbSNP
rs1035040825 673 dbSNP
rs767107852 674 dbSNP
rs966662118 675 dbSNP
rs529160891 677 dbSNP
rs1203652729 678 dbSNP
rs1261327470 687 dbSNP
rs1490517821 689 dbSNP
rs561983125 693 dbSNP
rs894088781 696 dbSNP
rs1479450378 702 dbSNP
rs139094784 703 dbSNP
rs1455178187 709 dbSNP
rs1286703982 711 dbSNP
rs1039289697 716 dbSNP
rs1222391615 722 dbSNP
rs1376066540 724 dbSNP
rs1008106778 726 dbSNP
rs1304498718 728 dbSNP
rs202176133 731 dbSNP
rs199528625 734 dbSNP
rs1344158309 735 dbSNP
rs549731893 738 dbSNP
rs5869716 740 dbSNP
rs1047841462 751 dbSNP
rs1260296547 758 dbSNP
rs578232896 759 dbSNP
rs1334074097 763 dbSNP
rs1360524341 774 dbSNP
rs890639447 775 dbSNP
rs531487428 780 dbSNP
rs1266930801 781 dbSNP
rs1454139775 782 dbSNP
rs920428707 784 dbSNP
rs929070155 791 dbSNP
rs918919092 796 dbSNP
rs969935780 801 dbSNP
rs34144066 814 dbSNP
rs1156669240 815 dbSNP
rs1037811823 816 dbSNP
rs1379296116 816 dbSNP
rs941710927 817 dbSNP
rs915782444 821 dbSNP
rs77150784 826 dbSNP
rs1164910532 827 dbSNP
rs1435169931 827 dbSNP
rs34572181 827 dbSNP
rs1279436686 828 dbSNP
rs1299185052 829 dbSNP
rs563848073 832 dbSNP
rs772439505 837 dbSNP
rs1309065519 838 dbSNP
rs1383774729 855 dbSNP
rs1248498072 857 dbSNP
rs1289911103 858 dbSNP
rs1358751558 859 dbSNP
rs992711805 861 dbSNP
rs959659164 862 dbSNP
rs1481613282 863 dbSNP
rs1031338002 866 dbSNP
rs1237392226 869 dbSNP
rs187089542 871 dbSNP
rs1185009223 872 dbSNP
rs928493742 873 dbSNP
rs1404176907 874 dbSNP
rs1170616132 879 dbSNP
rs746184318 883 dbSNP
rs1022440525 896 dbSNP
rs1331064867 901 dbSNP
rs777614607 903 dbSNP
rs1383944219 904 dbSNP
rs886060883 905 dbSNP
rs982146558 909 dbSNP
rs1313111502 910 dbSNP
rs1241552519 937 dbSNP
rs1378720185 943 dbSNP
rs1215232678 956 dbSNP
rs966798359 958 dbSNP
rs1483641828 961 dbSNP
rs573084670 963 dbSNP
rs900679715 971 dbSNP
rs1039266884 974 dbSNP
rs1257380141 989 dbSNP
rs1009195074 993 dbSNP
rs553276758 994 dbSNP
rs890453736 995 dbSNP
rs751191442 999 dbSNP
rs1047790469 1004 dbSNP
rs1319257046 1005 dbSNP
rs1426255101 1022 dbSNP
rs1170536235 1028 dbSNP
rs1389424007 1029 dbSNP
rs146200274 1032 dbSNP
rs17085675 1041 dbSNP
rs559695424 1045 dbSNP
rs1335218895 1046 dbSNP
rs920653145 1049 dbSNP
rs1431808838 1050 dbSNP
rs1037803172 1051 dbSNP
rs541743047 1063 dbSNP
rs1218115671 1068 dbSNP
rs1277411369 1069 dbSNP
rs1324276726 1083 dbSNP
rs1225104841 1084 dbSNP
rs754888095 1088 dbSNP
rs867846512 1097 dbSNP
rs1441455277 1104 dbSNP
rs1358234906 1108 dbSNP
rs62364643 1110 dbSNP
rs1007832299 1112 dbSNP
rs890616656 1120 dbSNP
rs1312513851 1121 dbSNP
rs1243514489 1130 dbSNP
rs139172738 1132 dbSNP
rs959979230 1138 dbSNP
rs1430607929 1143 dbSNP
rs766120820 1148 dbSNP
rs1174705092 1149 dbSNP
rs1424960207 1150 dbSNP
rs375965118 1154 dbSNP
rs1037466849 1158 dbSNP
rs886060882 1164 dbSNP
rs977513415 1166 dbSNP
rs968429925 1176 dbSNP
rs1021761032 1180 dbSNP
rs941665232 1185 dbSNP
rs758255839 1190 dbSNP
rs750163429 1192 dbSNP
rs1346044478 1193 dbSNP
rs1406737310 1196 dbSNP
rs964874776 1204 dbSNP
rs1056101250 1205 dbSNP
rs1224138522 1208 dbSNP
rs938628697 1212 dbSNP
rs765501872 1215 dbSNP
rs886060881 1231 dbSNP
rs373852338 1232 dbSNP
rs116448437 1233 dbSNP
rs1246661277 1234 dbSNP
rs913941125 1235 dbSNP
rs1184870591 1249 dbSNP
rs1487108506 1252 dbSNP
rs1160719889 1256 dbSNP
rs1406044574 1259 dbSNP
rs1419381062 1270 dbSNP
rs890735673 1280 dbSNP
rs1367483164 1281 dbSNP
rs1422842741 1285 dbSNP
rs558208576 1296 dbSNP
rs537248069 1297 dbSNP
rs1442663196 1298 dbSNP
rs1281132687 1301 dbSNP
rs1374175844 1304 dbSNP
rs958254294 1305 dbSNP
rs554558654 1307 dbSNP
rs1360915972 1308 dbSNP
rs1038150191 1318 dbSNP
rs986374945 1324 dbSNP
rs954980887 1330 dbSNP
rs6556922 1333 dbSNP
rs894303960 1335 dbSNP
rs539921041 1337 dbSNP
rs148552266 1339 dbSNP
rs898008354 1350 dbSNP
rs1246615426 1353 dbSNP
rs1439503629 1365 dbSNP
rs938579897 1367 dbSNP
rs764110111 1372 dbSNP
rs1387323942 1373 dbSNP
rs1321949739 1376 dbSNP
rs1005995532 1379 dbSNP
rs894118201 1383 dbSNP
rs1162806237 1391 dbSNP
rs1294160151 1400 dbSNP
rs886060880 1401 dbSNP
rs1055420258 1402 dbSNP
rs1445805717 1412 dbSNP
rs886060879 1414 dbSNP
rs1315242598 1418 dbSNP
rs761114809 1422 dbSNP
rs1384551394 1425 dbSNP
rs1241966211 1433 dbSNP
rs182581645 1443 dbSNP
rs144800629 1445 dbSNP
rs1041625127 1446 dbSNP
rs1256739305 1455 dbSNP
rs975562349 1459 dbSNP
rs1363558598 1464 dbSNP
rs963817516 1475 dbSNP
rs1194334147 1484 dbSNP
rs1458553194 1492 dbSNP
rs1186908872 1496 dbSNP
rs149426497 1499 dbSNP
rs1017768290 1506 dbSNP
rs1168367696 1511 dbSNP
rs1432629846 1512 dbSNP
rs1430419530 1518 dbSNP
rs987615565 1519 dbSNP
rs945840512 1522 dbSNP
rs2882298 1530 dbSNP
rs1464849855 1550 dbSNP
rs1337225827 1554 dbSNP
rs886060878 1571 dbSNP
rs531446200 1574 dbSNP
rs568954132 1577 dbSNP
rs760975352 1584 dbSNP
rs993765530 1592 dbSNP
rs936804929 1595 dbSNP
rs1276781128 1598 dbSNP
rs764975452 1598 dbSNP
rs1317902011 1600 dbSNP
rs1224488823 1612 dbSNP
rs1210818910 1613 dbSNP
rs1482383674 1629 dbSNP
rs899158730 1630 dbSNP
rs563936239 1641 dbSNP
rs551879996 1643 dbSNP
rs1448753883 1646 dbSNP
rs1012939596 1647 dbSNP
rs1260930870 1658 dbSNP
rs1250457065 1662 dbSNP
rs1201802247 1671 dbSNP
rs1319460561 1673 dbSNP
rs1278761961 1676 dbSNP
rs1176846391 1677 dbSNP
rs1222753158 1678 dbSNP
rs1343582510 1682 dbSNP
rs1464375152 1688 dbSNP
rs986091029 1690 dbSNP
rs1171574298 1702 dbSNP
rs954701448 1705 dbSNP
rs1385225889 1720 dbSNP
rs1383405074 1721 dbSNP
rs1303075750 1732 dbSNP
rs189919167 1733 dbSNP
rs1406142914 1738 dbSNP
rs1057161758 1739 dbSNP
rs1372832894 1750 dbSNP
rs1233004245 1757 dbSNP
rs1261466451 1759 dbSNP
rs1353192817 1785 dbSNP
rs1296714877 1786 dbSNP
rs565412629 1788 dbSNP
rs1401205887 1794 dbSNP
rs559780475 1806 dbSNP
rs372089972 1807 dbSNP
rs1175800277 1822 dbSNP
rs1468643487 1823 dbSNP
rs903029114 1825 dbSNP
rs1197984176 1836 dbSNP
rs1432106675 1841 dbSNP
rs10515236 1842 dbSNP
rs1418914413 1847 dbSNP
rs886060877 1854 dbSNP
rs1424774712 1855 dbSNP
rs866548174 1857 dbSNP
rs1366121507 1858 dbSNP
rs914212219 1861 dbSNP
rs1308233573 1866 dbSNP
rs1337721586 1868 dbSNP
rs1238194017 1872 dbSNP
rs1175190845 1873 dbSNP
rs975130732 1878 dbSNP
rs1360182003 1879 dbSNP
rs746297834 1880 dbSNP
rs1458819450 1883 dbSNP
rs1224818555 1887 dbSNP
rs1258080911 1892 dbSNP
rs894263267 1895 dbSNP
rs1208992897 1899 dbSNP
rs867458955 1903 dbSNP
rs942361815 1906 dbSNP
rs886060876 1912 dbSNP
rs1441351847 1917 dbSNP
rs1002457414 1918 dbSNP
rs1379320539 1922 dbSNP
rs574325243 1926 dbSNP
rs912287929 1932 dbSNP
rs562288544 1937 dbSNP
rs1193047773 1945 dbSNP
rs1166379232 1954 dbSNP
rs77800037 1955 dbSNP
rs1299271540 1961 dbSNP
rs946007920 1962 dbSNP
rs1402848042 1965 dbSNP
rs41276267 1967 dbSNP
rs1305125780 1968 dbSNP
rs1230086543 1989 dbSNP
rs1310723181 1998 dbSNP
rs1319819338 2002 dbSNP
rs1026522020 2015 dbSNP
rs1054335525 2017 dbSNP
rs942531136 2018 dbSNP
rs558370034 2019 dbSNP
rs1488926795 2037 dbSNP
rs1377940892 2041 dbSNP
rs1336103140 2044 dbSNP
rs986229923 2048 dbSNP
rs1237183839 2049 dbSNP
rs540005852 2049 dbSNP
rs1408916634 2060 dbSNP
rs1410937454 2076 dbSNP
rs1422749845 2084 dbSNP
rs1016657683 2086 dbSNP
rs185153811 2093 dbSNP
rs182407372 2095 dbSNP
rs572594428 2101 dbSNP
rs534780116 2102 dbSNP
rs554192613 2105 dbSNP
rs147244631 2115 dbSNP
rs3811941 2118 dbSNP
rs1161754851 2120 dbSNP
rs1002954960 2124 dbSNP
rs1215257698 2127 dbSNP
rs1441107558 2144 dbSNP
rs903009190 2155 dbSNP
rs1041583409 2158 dbSNP
rs1257242791 2160 dbSNP
rs886060875 2166 dbSNP
rs1323768389 2169 dbSNP
rs1211739070 2172 dbSNP
rs1235397679 2176 dbSNP
rs191960713 2187 dbSNP
rs962354594 2230 dbSNP
rs1182410100 2235 dbSNP
rs780874113 2243 dbSNP
rs1265954637 2249 dbSNP
rs1477154891 2268 dbSNP
rs886060874 2288 dbSNP
rs1039656759 2313 dbSNP
rs1416544753 2316 dbSNP
rs1174155863 2318 dbSNP
rs959133473 2323 dbSNP
rs1431570579 2339 dbSNP
rs1034031341 2348 dbSNP
rs1300180618 2352 dbSNP
rs1342269580 2361 dbSNP
rs1398115537 2364 dbSNP
rs1277513554 2366 dbSNP
rs1258164341 2372 dbSNP
rs1220742136 2377 dbSNP
rs1345382483 2377 dbSNP
rs1276059374 2384 dbSNP
rs1216670874 2388 dbSNP
rs1311305565 2388 dbSNP
rs556231424 2390 dbSNP
rs942309623 2392 dbSNP
rs367854792 2393 dbSNP
rs1201031214 2403 dbSNP
rs879943012 2405 dbSNP
rs537724412 2407 dbSNP
rs1270255574 2414 dbSNP
rs1479174431 2416 dbSNP
rs1019936726 2425 dbSNP
rs1258675143 2427 dbSNP
rs919406892 2431 dbSNP
rs1242075922 2441 dbSNP
rs1424712052 2449 dbSNP
rs1401554129 2451 dbSNP
rs1160502852 2455 dbSNP
rs1354627263 2456 dbSNP
rs1358660307 2466 dbSNP
rs1314694181 2472 dbSNP
rs1243861217 2475 dbSNP
rs1419185799 2479 dbSNP
rs972280403 2485 dbSNP
rs963896306 2487 dbSNP
rs1438330438 2489 dbSNP
rs1272905071 2500 dbSNP
rs1366426182 2501 dbSNP
rs1240367065 2504 dbSNP
rs1342413538 2507 dbSNP
rs1010568177 2523 dbSNP
rs909436389 2534 dbSNP
rs1350793620 2545 dbSNP
rs893015328 2555 dbSNP
rs570346851 2566 dbSNP
rs187137855 2570 dbSNP
rs1453897259 2572 dbSNP
rs1219795865 2573 dbSNP
rs1246532303 2575 dbSNP
rs1470735979 2582 dbSNP
rs1180679622 2585 dbSNP
rs1006696656 2586 dbSNP
rs1378702717 2589 dbSNP
rs754474461 2590 dbSNP
rs1383467819 2597 dbSNP
rs1439159728 2606 dbSNP
rs746472388 2611 dbSNP
rs1391333081 2621 dbSNP
rs1420736487 2622 dbSNP
rs1050484297 2634 dbSNP
rs1162598626 2635 dbSNP
rs1442234605 2636 dbSNP
rs1369620861 2641 dbSNP
rs1447267875 2649 dbSNP
rs967513865 2649 dbSNP
rs575092021 2652 dbSNP
rs1374290179 2653 dbSNP
rs923260455 2665 dbSNP
rs1011379880 2666 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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