miRTarBase - #MIRT440166


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pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MYH14   
Synonyms DFNA4, DFNA4A, FP17425, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin
Description myosin heavy chain 14
Transcript NM_001077186   
Other Transcripts NM_001145809 , NM_024729   
Expression
Putative miRNA Targets on MYH14
3'UTR of MYH14
(miRNA target sites are highlighted)		 
>MYH14|NM_001077186|3'UTR
   1 CCCTACCCTGTCCCCAGATGCACTAACAGATGGGGCCCAGCCCCCTTCCTCCCTGGACCCCACGGGCCCCTGTCCCAGGA
  81 ACCCCGCCCTCTGACTTCTTGCCCTTTGGAAATGGTGCAGCACTCTGGCATTTATCACCCCCACCTGGGTCCCCTGCAAC
 161 CTCCCATCAAAGGATGACCCCTAAACACAGAGGAGCGGGGCAGGCAGGGAGGCAATGACTGGAGCTACCTTGCTTGTTGG
 241 GGGACTGGGTACAGTTGGCAAGCTGTGTTTCCATCAGCTCCCTGTCCTCCTTTCTTCCCTCGTTATTGATCTATAGACAT
 321 TAGGAAGGGAGTGAGACGGCTCCTCCACCATCCTCAGCCAGTGCAACCCATTCCCTCTGCTTCTCTCTCTCTCTCTCTCT
 401 CTCCCTCCCTCTCCTTCCCTACCCTCTCACCATCTTTCTTGGCCTCTCTGAGGGTCTCTCTGTGCATCTTTTTAGGAATC
 481 TCGCTCTCACTCTCTACGTAGCCACTCTCCTTCCCCCATTTCTGCGTCCACCCCTGAACTCCTGAGCGACAGAAGCCCCA
 561 GGCCTCCACCAGCCTTGAACCCTTGCAAAGGGGCAGGACAAGGGGACCCCTCTCACTCCTGCTGCTGCCCATGCTCTGCC
 641 CTCCCTTCTGGTTGCTCTGAGGGTTCGGAGCTTCCCTCTGGGACTAAAGGAGTGTCCTTTACCCTCCCAGCCTCCAGGCT
 721 CTGGCAGAAATAAACTCCAACCCGACTGGACCATAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugccgaucACCUGGUCCACUUCa 5'
                  ||||   |||| || 
Target 5' ttgcccttTGGAAATGGTGCAGc 3'
 99 - 121 119.00 -11.00
2 
miRNA  3' ugcCGAUCACCUGGUCCACUUCa 5'
             |:|:| ||||::|||  || 
Target 5' cttGTTGGGGGACTGGGTACAGt 3'
 233 - 255 112.00 -19.70
3 
miRNA  3' ugccGAUCACCUGG---UCCA--CUUCa 5'
              ||:|| | :|   :|||  |:|| 
Target 5' ccttCTGGTTGCTCTGAGGGTTCGGAGc 3'
 644 - 671 99.00 -12.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
329953 65 ClinVar
329954 82 ClinVar
894015 87 ClinVar
329955 123 ClinVar
329956 143 ClinVar
329957 145 ClinVar
894417 156 ClinVar
329958 217 ClinVar
329959 244 ClinVar
329960 302 ClinVar
329961 303 ClinVar
329962 338 ClinVar
892974 369 ClinVar
329963 382 ClinVar
329964 382 ClinVar
329965 390 ClinVar
329966 401 ClinVar
892975 428 ClinVar
329967 475 ClinVar
329968 532 ClinVar
893199 605 ClinVar
329969 668 ClinVar
893200 739 ClinVar
COSM8554304 6 COSMIC
COSM7543717 9 COSMIC
COSM6213464 17 COSMIC
COSM8654188 30 COSMIC
COSM8647711 52 COSMIC
COSM8650368 85 COSMIC
COSN9851639 195 COSMIC
COSN1217619 201 COSMIC
COSN32071088 403 COSMIC
COSN1770451 467 COSMIC
COSN17037431 697 COSMIC
COSN16461556 744 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768153073 1 dbSNP
rs1023277492 2 dbSNP
rs765102545 4 dbSNP
rs1340472326 5 dbSNP
rs1337597373 6 dbSNP
rs1259907744 7 dbSNP
rs769359886 9 dbSNP
rs774314722 11 dbSNP
rs766275446 12 dbSNP
rs1362081087 13 dbSNP
rs1217565196 14 dbSNP
rs1255770083 15 dbSNP
rs371235709 16 dbSNP
rs1438380083 17 dbSNP
rs1204133031 21 dbSNP
rs976576773 27 dbSNP
rs1277788027 33 dbSNP
rs754439562 36 dbSNP
rs1036378772 37 dbSNP
rs1173434296 39 dbSNP
rs1243881862 41 dbSNP
rs1206110385 45 dbSNP
rs1478194377 46 dbSNP
rs1466559533 47 dbSNP
rs1429239889 52 dbSNP
rs1193145624 56 dbSNP
rs780715963 57 dbSNP
rs1479217461 59 dbSNP
rs1030330334 60 dbSNP
rs1181440714 61 dbSNP
rs956269769 62 dbSNP
rs752312470 63 dbSNP
rs755809721 64 dbSNP
rs779130953 65 dbSNP
rs1345205563 68 dbSNP
rs1460782789 69 dbSNP
rs572631657 72 dbSNP
rs1275904041 76 dbSNP
rs772326631 82 dbSNP
rs780550154 86 dbSNP
rs772673014 87 dbSNP
rs1236495276 89 dbSNP
rs1169353101 96 dbSNP
rs546411129 101 dbSNP
rs1225332176 107 dbSNP
rs761718453 111 dbSNP
rs968806542 113 dbSNP
rs776901343 115 dbSNP
rs911210577 117 dbSNP
rs1490887418 122 dbSNP
rs12978083 123 dbSNP
rs766679106 125 dbSNP
rs1477252392 129 dbSNP
rs1416512577 134 dbSNP
rs1160781191 135 dbSNP
rs556063581 139 dbSNP
rs1057321857 142 dbSNP
rs770209944 143 dbSNP
rs773312540 145 dbSNP
rs1040963691 150 dbSNP
rs918532693 156 dbSNP
rs929791430 157 dbSNP
rs929654417 171 dbSNP
rs1235649838 174 dbSNP
rs1048705015 176 dbSNP
rs1465796826 180 dbSNP
rs1048111587 191 dbSNP
rs576031713 198 dbSNP
rs1210935131 201 dbSNP
rs1011966126 202 dbSNP
rs888002456 209 dbSNP
rs627491 217 dbSNP
rs1244586974 219 dbSNP
rs1454127431 226 dbSNP
rs1039165394 242 dbSNP
rs561898739 244 dbSNP
rs1360270680 250 dbSNP
rs1318020535 254 dbSNP
rs1418255216 257 dbSNP
rs1362626543 262 dbSNP
rs1003661286 269 dbSNP
rs1035941349 274 dbSNP
rs1387812161 282 dbSNP
rs529409417 302 dbSNP
rs544178350 303 dbSNP
rs1391962876 305 dbSNP
rs1473064946 307 dbSNP
rs1386011754 320 dbSNP
rs1241450789 334 dbSNP
rs753307318 338 dbSNP
rs1333103900 339 dbSNP
rs186982330 354 dbSNP
rs377444835 357 dbSNP
rs1021591833 359 dbSNP
rs968571618 361 dbSNP
rs1291342075 366 dbSNP
rs1287849467 367 dbSNP
rs1380439241 368 dbSNP
rs74582015 369 dbSNP
rs927144911 374 dbSNP
rs79499376 376 dbSNP
rs1187786369 382 dbSNP
rs1418693773 382 dbSNP
rs376379600 382 dbSNP
rs538810577 382 dbSNP
rs761762835 382 dbSNP
rs886054594 382 dbSNP
rs886054595 382 dbSNP
rs918310533 382 dbSNP
rs149455351 390 dbSNP
rs570759880 396 dbSNP
rs1271866256 398 dbSNP
rs1488323521 399 dbSNP
rs1248095191 401 dbSNP
rs886054596 401 dbSNP
rs911348257 403 dbSNP
rs537716543 406 dbSNP
rs1217391761 408 dbSNP
rs1320654768 410 dbSNP
rs1267600832 416 dbSNP
rs1386568472 419 dbSNP
rs1453041387 427 dbSNP
rs190088995 428 dbSNP
rs1410651183 429 dbSNP
rs1437280496 433 dbSNP
rs1053991 439 dbSNP
rs567917288 447 dbSNP
rs1472646722 454 dbSNP
rs1354054473 461 dbSNP
rs1168418686 471 dbSNP
rs886054597 475 dbSNP
rs1161198188 477 dbSNP
rs918471524 483 dbSNP
rs1039728672 484 dbSNP
rs1431241842 485 dbSNP
rs1426813497 488 dbSNP
rs1191477068 490 dbSNP
rs900656819 491 dbSNP
rs929902352 492 dbSNP
rs764240575 498 dbSNP
rs909706020 499 dbSNP
rs1393102210 510 dbSNP
rs947914355 518 dbSNP
rs1053995 523 dbSNP
rs1303643165 526 dbSNP
rs1044791859 527 dbSNP
rs906328498 530 dbSNP
rs886054598 532 dbSNP
rs1003178012 543 dbSNP
rs1351142263 545 dbSNP
rs1052535104 548 dbSNP
rs1291919454 549 dbSNP
rs535549417 553 dbSNP
rs1369788805 557 dbSNP
rs1321709858 561 dbSNP
rs753971693 565 dbSNP
rs1378102583 567 dbSNP
rs1021539838 573 dbSNP
rs1439838976 578 dbSNP
rs968727650 580 dbSNP
rs1200431071 583 dbSNP
rs967091412 594 dbSNP
rs892017404 596 dbSNP
rs1034706318 599 dbSNP
rs1010890570 606 dbSNP
rs1202529988 607 dbSNP
rs960005098 607 dbSNP
rs1250619367 610 dbSNP
rs993043811 610 dbSNP
rs1242388968 611 dbSNP
rs1483062809 627 dbSNP
rs866924363 644 dbSNP
rs1377828288 661 dbSNP
rs1311878870 664 dbSNP
rs553952601 665 dbSNP
rs572169961 667 dbSNP
rs886054599 668 dbSNP
rs1253992561 673 dbSNP
rs1418881973 674 dbSNP
rs1423211481 694 dbSNP
rs1160160666 700 dbSNP
rs1165182964 710 dbSNP
rs1419744731 714 dbSNP
rs1384125578 720 dbSNP
rs1054011 722 dbSNP
rs1369928858 723 dbSNP
rs757578666 726 dbSNP
rs1422537513 736 dbSNP
rs540069517 739 dbSNP
rs567968417 744 dbSNP
rs558366138 745 dbSNP
rs1488199134 751 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
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138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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