miRTarBase - #MIRT440269


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MBP   
Synonyms -
Description myelin basic protein
Transcript NM_001025100   
Other Transcripts NM_001025090 , NM_001025092 , NM_001025081 , NM_001025101 , NM_002385   
Expression
Putative miRNA Targets on MBP
3'UTR of MBP
(miRNA target sites are highlighted)		 
>MBP|NM_001025100|3'UTR
   1 AGGAGTTTTAGTTTAAATGGAAAAAGCAAAGGAGAAATCAGTAGGTGAACTCAGCCATTAGAGGAAGAACTGGCACGTAG
  81 CCTCTTGCTGTCTAAGGTCTCGTTCCGTGCTGGAGAATGCATATGAGCCCAAGAGTGTGGGCCTGAGTGGCTGCTTAGGA
 161 CGTTTTCGTTTAACTCACCCCCTCTTTTCCTCACAAGGGATGGTGGCCGGGGTGTGGCTCAGGAATGTAAGGACATGCTG
 241 AATTCTGGATCTCTAAGGGTGCCTGGACATGGGCGTTGCAGAAAGAGAGCCACATTCTCAGGGTCTCTGGTGGTGTGTGC
 321 TTGCGGACTTGATGACTGATGTTGCCTCTGCAGCCCACACGCTGGGGTTCAACACTGGGTTATGCTCGTTTTTTCCTGGA
 401 GTCAGTGCTGCTAGCTTCATGTTGCTCTGCGACAATCATAGGATTGAGGTCGAGGAAGACTTTTGAACAAACTCCTCAAT
 481 TTAAATCCGCCTTGAGCAAACGTTCTCTGTGGTCTGAGAAGTGGAAGGGGGGAGGGATAAATGAGTGTCTATGAATCAAA
 561 GCTTTATTATCTTGTGATTCCATTAATTTGCATACAGAGTCTTAGAAGTTTCTTTATTCAAAAGCAAATGTGGATAAAAA
 641 TGTATTACAAAAAAAAAAAACTCTGCTATGGGGTCCAGAGTCTAGGAGTGGTTTCTGCAGTTGATTGTCAGTGGAGAACC
 721 TGTGGCTGCTGGTTCATCAAAGCGCTGGTCCCTGAGTGCCATTCAGATTGCAGATGCAGTATTTTACGTGATGTTTAGAG
 801 TGTTTGGTGGTTGTGTAATTTTGGAGAGAAAGAAGTTTTTCCCAAAAAAGTCCCTAGTTTATTGGGTGTTCTCACACAAC
 881 CTGTAAGATGAAGCTGTTTTTCTGCCTGTGTGCAGGGCTGATTCTGGAATTCCAGAAGGCCTTGTGGGAGCGTAAAAGGC
 961 TTTTGAATAAAGTGTGGAACAGAGCGCCTCATTCTGATAACATGCAATCATAAAAACCATAGGGCAACTTGGAGTTAAGG
1041 AGTTTCTAGAATTTGCTTTAGTCTCCAACTGCAATTCTTTATTGATCATGAAATTGTTGAAGAGAAACACAAATGTCAGT
1121 TTTACCTTTCCTGTGGGCGTGAAAGCACATCGAAGTTTCAGGCAACTGTTAACATCTCTACCATCTGTCTGAGTTGAGAT
1201 TTCAGGTTGTGACACTTGCCGTGACTTATTTGTAAATGACATTTTGTGTGTCTTAGATACTAATGGAATTCATATTCTGG
1281 CTAGTTCTTTCAGTGCATTTGTAGACATGTTCTTTTCCTTTGTAGCAGTCCTCCCTCACCCTGAAATGTTGGTGTTCTAA
1361 CCGATTTCTAATGCTAATTTCAACTGGAAGCACTTTTTCAAGCCCAGCTATCAAACCACACCAGACATGTATGGATTCGG
1441 GTTGCCCAATAAAGCGTTGCTATTATGTAAGCATCCCTCACGCATACAGCATCACCAGTTTTGAAAGCTTGAACTATTCT
1521 GCTTACTTCAAGGTACAGAAAAAAAAAATGTACTTAAACTGTGCAGAAAAGATGAAATCACTGGATAATATGTATTATAA
1601 AATAAGCTTCATGTGAGTGACACTGGTTTAAGTTGAAATAAAATGGTGAAAGCATTGATATCAATCATTGTGACTTTATC
1681 TCAAAACAATATTGACACACATAGATGTTTTTCTTCCTTTATGGTAAGATTACAGCCTTTATTGTCTTAAATCTCTTATA
1761 CTCTTCAATATTTTCAAAGAAAACATTCTAGTCTCAGAAATAGTCCATCTCTTTGCAAAACAGGGCTGGCCAATTATCAA
1841 GGACCCATAAAAATCAAAACACTTTCAAAAATTTTAAAAATAAAAATAATTTTCACATGATTGCTTTAGGAATTTTGAAG
1921 TATCCATTCTTTTCACTATGGAGTGTTGAATATAGAAGATTTTTTAATGAACAGGCTTGCCCTTTGATGCCAAAGGCAAA
2001 AAATAATAATAATAACATTTGCACGTGTGATCACAGAGCAGCTGTGAGGCATCCCGGGGGAGCGCACGCAGTGGGGATGT
2081 GATTGCTCCACTCAACTATTTTATCACAAAGTGTTGTAAACATGGGAGATGAAAGCTTAACTCTCTCTACACCCAGCTAC
2161 AGACCCGCAATGGCCCTAAAAATCTGGGGTATTCATTGGGTGGGCTGCCATGGAGGAATTTTTGGTTTTGTTTTTATTTT
2241 TATTTGTTGTTCTGTTTACAAATCAGGAGAGCCCCTGTTTTTATATGCTAGGAAGGTCCTTGGGATAGGCCGAAGAGGTG
2321 TGCAAACGAGCAGTGGAAGGCCCGGGCCCTGTCTCTCAGGACCACGGCGGCCTGCCCCACACACAGTTCTGCTTCTCCCT
2401 ATCTAGAACGAGGTTTTCCTGGCAGATTCCTGCCAGACTCTGAGTGGAGCCCCCCCATGACCCTATAAAAGGGGCTGTTT
2481 GTCCTCCTCCCACCCTCCTGTGCTCTTCCTCCCTCCCCTTGAGGGCACATGGCCGCTGGTACCACATGTTGGAGCGGCCG
2561 CCCCCGAGCCCGGGAATGCCCTAACAACACCCATGCTTGTGTTGCTGGGAGCTGACATTCAAGAAAAGTGCATTAAAAAT
2641 TCCTTGAGAAGGCATATTCTTTTGAGAGCCGTAAATGAAAAGTGCATTCACGGAGAACATGCTCCTTTGTTGTGAGAGGA
2721 AAGAAAGGACTGTTGTTGCCTTTAAGGAACAGGTTTCCCAGTTCCCCGGAATGTCAGGGTCACATGAGGAATGGGTGAGC
2801 ACTTAGGGCCAAGATTGTCGTGTGCTTGGCCCGGCAGCTTCTCTCTAAGTGACCTCTCCAGCATCACTCTGTGCCAGTGC
2881 TCATATCTGAGGCCACTTGAGTGTCACGAGGCAGAGCCTGGAAACATTAGCTTTGGAAACCGTTCCTTCCTTTTTATGTG
2961 GAGGAAGTAAGGTTTCACAAGACACCTAAGCTGGACATGGTGATGTGCCACTTGGATAGTTCCCAAAGCAGAAAGCAGCC
3041 AGGACATCCCAGTACCCCACTTCTCCGTGCCGTGTACTTTTAGGGAGGTTTTCGAAAGCTAGCTTCTTACCGATGATTTT
3121 GTCTATTTTTCTGTTTTATGTGAAAACCTTCATTTATAACCTGCTCTTCTCAGTGTTCTTCTATTCAGCATTCAGTATGA
3201 CTTCTATGCCTCTAATTGCGACTGTATGGAGAAGAACTGTTTGTCATTCAGTGCCGTGGGATATAATCAGTCCTGTAAAT
3281 TCATCAGAATGTTCTGTTGCCTGATTTTTTTTCCATTGCATTTTAATTTCATTAAACATATTTTAGTTCTACAGTAACCT
3361 AATTCCTCATTGTTACCATGAGATCCTAATTCTGTAGCTGTGTTCTGTAATCCCATGGGGCGTGTACCATTTGGAGACAC
3441 ATGAAGGATACAGTAGACAGCACGGAAGGCAGCAGCAACACACAGGGGTGTCCTCCCTCCCCAGAGCCCAGTGTGCACAC
3521 AGAACCAAATTCAATCTCATTCATCGTGAGCTTGCATGGTAACTGATCCAGCCACTCAGTACCTCCATTGGATAAGAGAT
3601 TTGGCCACAGATTCTTCTAGAGAAAATCCAAATGTGGAGGGTGCATTTGTTTCTGCACCCAAACAAATACCTTTTGAGAT
3681 TTCTTATAGGCATTCCTCTCAAAGTCTCATTACTCTGATCAGTTATTGATCGGAGGCTACCCTGGCTCAGTCACCAGCTG
3761 CTCACTGTGTCCTTCTGTGGTCTCAGGAGCTGCAGTTGTTGCTGTTGTATGAATAGACGATAGTTAATTAGACTGGATGT
3841 GTCTGTACTGGCAGTGATTTTGCAACTTCCTCTGTATAAGCGATACATTTGTAAATCATGGGAATGTATTTGATGGTAAT
3921 TGCCTGTGGTGGTTGTATCATGATTTAATTTTATTATGAGCTTTTGGCTTTATATATTTTTCTGCCTTTTTATGCATTCA
4001 TTAAACAGTTTAACAGACCAAGGACAGTGTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGUCUCGG--GAGAC--UCGAAGUc 5'
            ::|||:|  : |||  ||||||| 
Target 5' ccTGGAGTCAGTGCTGCTAGCTTCAt 3'
 395 - 420 156.00 -16.30
2 
miRNA  3' uagucucgggagACUCGAAGUc 5'
                      | ||||||| 
Target 5' tgtattataaaaTAAGCTTCAt 3'
 1591 - 1612 142.00 -8.80
3 
miRNA  3' uagUCUCG-GGAGACUCGAAGUc 5'
             | ||| | ||  ||:|||| 
Target 5' gtgAAAGCACATCGAAGTTTCAg 3'
 1139 - 1161 139.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30501242 2 COSMIC
COSN31509850 8 COSMIC
COSN31568083 106 COSMIC
COSN29733424 167 COSMIC
COSN31564618 168 COSMIC
COSN31578409 295 COSMIC
COSN31593362 325 COSMIC
COSN16809874 340 COSMIC
COSN26568634 452 COSMIC
COSN29083753 488 COSMIC
COSN22052294 576 COSMIC
COSN20115191 648 COSMIC
COSN27206864 648 COSMIC
COSN20115188 1539 COSMIC
COSN6135872 1762 COSMIC
COSN28237172 1959 COSMIC
COSN6135871 2681 COSMIC
COSN26100152 2942 COSMIC
COSN26094157 3206 COSMIC
COSN29772395 3266 COSMIC
COSN22274692 3495 COSMIC
COSN1758170 3499 COSMIC
COSN23353157 3669 COSMIC
COSN30301904 3672 COSMIC
COSN26072378 3707 COSMIC
COSN26796120 3780 COSMIC
COSN9844831 3783 COSMIC
COSN17875239 3996 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs535620441 2 dbSNP
rs1256908341 3 dbSNP
rs1316796567 5 dbSNP
rs528177995 7 dbSNP
rs968976639 10 dbSNP
rs1484451713 18 dbSNP
rs1021483860 19 dbSNP
rs746461097 24 dbSNP
rs768330784 26 dbSNP
rs748981887 28 dbSNP
rs1394103236 30 dbSNP
rs145031965 31 dbSNP
rs200137627 32 dbSNP
rs1378996110 40 dbSNP
rs1031113595 41 dbSNP
rs1180553910 42 dbSNP
rs777449273 43 dbSNP
rs368665621 52 dbSNP
rs753440518 59 dbSNP
rs545578102 67 dbSNP
rs999075478 76 dbSNP
rs1464355410 77 dbSNP
rs1302110615 80 dbSNP
rs193219722 99 dbSNP
rs1210408186 101 dbSNP
rs1400921004 102 dbSNP
rs989122046 105 dbSNP
rs755862624 107 dbSNP
rs575124634 109 dbSNP
rs1002877330 113 dbSNP
rs1302947904 115 dbSNP
rs533217895 121 dbSNP
rs1043356111 123 dbSNP
rs564149360 135 dbSNP
rs748451805 136 dbSNP
rs1262954838 140 dbSNP
rs1051448957 143 dbSNP
rs1201095147 147 dbSNP
rs1256687968 154 dbSNP
rs1191915476 159 dbSNP
rs550514150 161 dbSNP
rs1047919840 167 dbSNP
rs1300243875 168 dbSNP
rs918990876 174 dbSNP
rs929550168 181 dbSNP
rs1436363069 182 dbSNP
rs1036139563 183 dbSNP
rs902141142 187 dbSNP
rs1040656030 189 dbSNP
rs943722500 194 dbSNP
rs117900820 201 dbSNP
rs766574375 206 dbSNP
rs562391222 208 dbSNP
rs985597326 209 dbSNP
rs541736537 211 dbSNP
rs914384017 221 dbSNP
rs142836347 222 dbSNP
rs1256714779 234 dbSNP
rs1307485015 235 dbSNP
rs988683332 264 dbSNP
rs955903341 266 dbSNP
rs1035614694 268 dbSNP
rs981412187 270 dbSNP
rs573407910 271 dbSNP
rs970481183 274 dbSNP
rs372073929 275 dbSNP
rs1190273550 280 dbSNP
rs992106718 286 dbSNP
rs1347629974 290 dbSNP
rs762925515 294 dbSNP
rs1006702174 296 dbSNP
rs1298433928 297 dbSNP
rs1342058365 302 dbSNP
rs1402230685 304 dbSNP
rs1327036908 309 dbSNP
rs1276758886 322 dbSNP
rs887901626 324 dbSNP
rs540342099 325 dbSNP
rs1320015722 329 dbSNP
rs1221942183 333 dbSNP
rs1236697842 337 dbSNP
rs1489420842 338 dbSNP
rs1185270534 342 dbSNP
rs1191196519 352 dbSNP
rs993627043 355 dbSNP
rs1241337303 357 dbSNP
rs767219193 360 dbSNP
rs902077261 361 dbSNP
rs1021459202 372 dbSNP
rs1040624782 388 dbSNP
rs1051713538 390 dbSNP
rs1340287851 396 dbSNP
rs1276952803 400 dbSNP
rs1316634778 401 dbSNP
rs1326237403 404 dbSNP
rs1449329407 414 dbSNP
rs112039188 419 dbSNP
rs762288496 420 dbSNP
rs1377719157 423 dbSNP
rs1245307509 426 dbSNP
rs897529016 430 dbSNP
rs148530136 431 dbSNP
rs1214746141 438 dbSNP
rs1049440416 439 dbSNP
rs1283223584 442 dbSNP
rs145777013 443 dbSNP
rs575485767 451 dbSNP
rs988609885 452 dbSNP
rs1235649945 459 dbSNP
rs1443989794 460 dbSNP
rs934493082 462 dbSNP
rs1341639177 465 dbSNP
rs1381659446 478 dbSNP
rs1437385246 479 dbSNP
rs367737397 488 dbSNP
rs1408757572 489 dbSNP
rs981338185 489 dbSNP
rs1336625304 494 dbSNP
rs1452585332 497 dbSNP
rs1368172052 501 dbSNP
rs555478468 502 dbSNP
rs535360055 507 dbSNP
rs948250649 521 dbSNP
rs1170036181 522 dbSNP
rs190475381 524 dbSNP
rs776430429 528 dbSNP
rs58981767 530 dbSNP
rs1199219366 533 dbSNP
rs534242300 533 dbSNP
rs1456076513 535 dbSNP
rs1180558765 536 dbSNP
rs1161286189 538 dbSNP
rs1026372416 561 dbSNP
rs1478827826 562 dbSNP
rs1238039351 566 dbSNP
rs1174633726 567 dbSNP
rs993604141 569 dbSNP
rs149804561 578 dbSNP
rs1469683791 580 dbSNP
rs185027956 585 dbSNP
rs968176939 591 dbSNP
rs1482080626 598 dbSNP
rs1019102188 599 dbSNP
rs1328329582 616 dbSNP
rs1008217854 617 dbSNP
rs1451287393 622 dbSNP
rs1288136923 627 dbSNP
rs570046380 629 dbSNP
rs1230442214 630 dbSNP
rs191370980 631 dbSNP
rs550595692 634 dbSNP
rs1279420156 641 dbSNP
rs1227107578 646 dbSNP
rs896317149 648 dbSNP
rs1309358070 649 dbSNP
rs1219099356 652 dbSNP
rs985949872 657 dbSNP
rs1410023631 659 dbSNP
rs1172700290 661 dbSNP
rs1337438770 661 dbSNP
rs34095806 661 dbSNP
rs60107323 661 dbSNP
rs67963100 661 dbSNP
rs1476566407 662 dbSNP
rs1192318422 665 dbSNP
rs530912021 667 dbSNP
rs763343509 668 dbSNP
rs997476656 670 dbSNP
rs892847931 678 dbSNP
rs1407237265 680 dbSNP
rs1301534776 700 dbSNP
rs1014595353 705 dbSNP
rs568334122 710 dbSNP
rs139627934 719 dbSNP
rs1044814837 721 dbSNP
rs760608937 722 dbSNP
rs1045624412 736 dbSNP
rs1158266380 744 dbSNP
rs1471587223 751 dbSNP
rs1219702233 756 dbSNP
rs1414234521 772 dbSNP
rs186944442 774 dbSNP
rs866278919 778 dbSNP
rs1194799369 779 dbSNP
rs558319819 787 dbSNP
rs182667708 788 dbSNP
rs867466458 797 dbSNP
rs985160343 801 dbSNP
rs1193118323 802 dbSNP
rs192712056 805 dbSNP
rs896692218 807 dbSNP
rs952098982 816 dbSNP
rs188499304 817 dbSNP
rs564156465 820 dbSNP
rs1420588329 823 dbSNP
rs972111800 826 dbSNP
rs543897089 829 dbSNP
rs368213302 833 dbSNP
rs1381510809 836 dbSNP
rs517525 840 dbSNP
rs1019068591 845 dbSNP
rs1342254304 861 dbSNP
rs1243108074 865 dbSNP
rs1313789926 875 dbSNP
rs75064842 880 dbSNP
rs1207346783 883 dbSNP
rs376158605 895 dbSNP
rs1204987036 904 dbSNP
rs946738421 908 dbSNP
rs573008158 909 dbSNP
rs1022559632 911 dbSNP
rs1181800158 930 dbSNP
rs1366466005 938 dbSNP
rs1384707730 940 dbSNP
rs552795703 942 dbSNP
rs745349296 951 dbSNP
rs539232882 952 dbSNP
rs1452770094 954 dbSNP
rs770523788 958 dbSNP
rs911294018 959 dbSNP
rs369125527 965 dbSNP
rs551516330 965 dbSNP
rs569496406 970 dbSNP
rs1350211814 973 dbSNP
rs781703731 985 dbSNP
rs998595550 986 dbSNP
rs906988243 992 dbSNP
rs1238757107 1005 dbSNP
rs1390814981 1010 dbSNP
rs118032229 1019 dbSNP
rs1432594972 1020 dbSNP
rs1423173918 1024 dbSNP
rs1193090337 1029 dbSNP
rs1242539093 1032 dbSNP
rs536166384 1050 dbSNP
rs1179079410 1053 dbSNP
rs1406034208 1062 dbSNP
rs147406960 1063 dbSNP
rs1015283322 1068 dbSNP
rs1005866452 1070 dbSNP
rs62105705 1071 dbSNP
rs1187121257 1072 dbSNP
rs1175625409 1073 dbSNP
rs867433691 1074 dbSNP
rs117335468 1087 dbSNP
rs972078930 1088 dbSNP
rs1296000124 1094 dbSNP
rs1210038173 1098 dbSNP
rs944753966 1099 dbSNP
rs1387028877 1106 dbSNP
rs183485580 1109 dbSNP
rs1326106432 1114 dbSNP
rs1056575271 1118 dbSNP
rs1275931382 1119 dbSNP
rs986676494 1130 dbSNP
rs1371342594 1131 dbSNP
rs192162300 1138 dbSNP
rs12959006 1139 dbSNP
rs1206678005 1151 dbSNP
rs7232502 1152 dbSNP
rs1480401626 1153 dbSNP
rs1192010270 1159 dbSNP
rs1270696968 1161 dbSNP
rs1044394315 1162 dbSNP
rs1198497463 1173 dbSNP
rs1321073598 1174 dbSNP
rs946737766 1175 dbSNP
rs1411634760 1178 dbSNP
rs1167655789 1182 dbSNP
rs1353441821 1183 dbSNP
rs989735742 1184 dbSNP
rs1465506003 1185 dbSNP
rs142844021 1189 dbSNP
rs1178378087 1199 dbSNP
rs1372621502 1207 dbSNP
rs1403464347 1215 dbSNP
rs1283089182 1219 dbSNP
rs1031337288 1220 dbSNP
rs551874335 1221 dbSNP
rs530584412 1231 dbSNP
rs1277855062 1233 dbSNP
rs140658405 1252 dbSNP
rs187100049 1265 dbSNP
rs7236968 1267 dbSNP
rs1489935344 1269 dbSNP
rs1198386938 1271 dbSNP
rs183398239 1281 dbSNP
rs1476325519 1282 dbSNP
rs541458492 1302 dbSNP
rs572836342 1305 dbSNP
rs1418794299 1307 dbSNP
rs552826249 1308 dbSNP
rs1164983573 1320 dbSNP
rs894297710 1329 dbSNP
rs1049403697 1330 dbSNP
rs1423640231 1334 dbSNP
rs1482585392 1339 dbSNP
rs930561371 1347 dbSNP
rs545664087 1348 dbSNP
rs1235219702 1351 dbSNP
rs1346171064 1352 dbSNP
rs897750381 1354 dbSNP
rs576640710 1362 dbSNP
rs556836957 1363 dbSNP
rs907781333 1367 dbSNP
rs147137062 1385 dbSNP
rs568457112 1393 dbSNP
rs36073460 1399 dbSNP
rs1357506549 1400 dbSNP
rs1222056773 1417 dbSNP
rs1348145386 1426 dbSNP
rs944724419 1428 dbSNP
rs1448512120 1429 dbSNP
rs1213450971 1430 dbSNP
rs1273377373 1436 dbSNP
rs753991881 1438 dbSNP
rs1225740119 1439 dbSNP
rs1382878067 1441 dbSNP
rs1443570185 1444 dbSNP
rs986212928 1445 dbSNP
rs932086574 1446 dbSNP
rs763942713 1450 dbSNP
rs1011925455 1452 dbSNP
rs1345084941 1455 dbSNP
rs960455455 1456 dbSNP
rs760449545 1462 dbSNP
rs1035210348 1464 dbSNP
rs1245419465 1466 dbSNP
rs376586590 1477 dbSNP
rs999682815 1479 dbSNP
rs189708233 1481 dbSNP
rs1221825568 1482 dbSNP
rs1283331709 1499 dbSNP
rs574639249 1510 dbSNP
rs1304647166 1529 dbSNP
rs1415546023 1533 dbSNP
rs1370034055 1534 dbSNP
rs1166887825 1535 dbSNP
rs1431893727 1536 dbSNP
rs1391136472 1538 dbSNP
rs1011171097 1544 dbSNP
rs956900760 1546 dbSNP
rs10713423 1549 dbSNP
rs1234237051 1549 dbSNP
rs1164576141 1550 dbSNP
rs1031265141 1552 dbSNP
rs1157154566 1553 dbSNP
rs977054404 1555 dbSNP
rs1416667514 1556 dbSNP
rs1182951847 1557 dbSNP
rs1470558743 1559 dbSNP
rs1179221936 1560 dbSNP
rs1404605611 1566 dbSNP
rs1049776014 1571 dbSNP
rs1485678125 1572 dbSNP
rs1440318193 1574 dbSNP
rs185098399 1606 dbSNP
rs934035540 1614 dbSNP
rs1250451458 1635 dbSNP
rs767328160 1643 dbSNP
rs1261164622 1648 dbSNP
rs1024421183 1657 dbSNP
rs566407471 1658 dbSNP
rs1274542359 1659 dbSNP
rs1435667763 1674 dbSNP
rs1180667525 1678 dbSNP
rs894257330 1680 dbSNP
rs1232601988 1688 dbSNP
rs1037561708 1697 dbSNP
rs1202101111 1699 dbSNP
rs940526709 1704 dbSNP
rs1251654837 1721 dbSNP
rs1469764662 1721 dbSNP
rs1243873009 1724 dbSNP
rs1408358061 1733 dbSNP
rs1319850161 1736 dbSNP
rs552928047 1737 dbSNP
rs1328429172 1743 dbSNP
rs1027451090 1746 dbSNP
rs994638356 1759 dbSNP
rs1314699417 1764 dbSNP
rs897719356 1766 dbSNP
rs1233838734 1770 dbSNP
rs1036256717 1774 dbSNP
rs944649151 1785 dbSNP
rs141646568 1800 dbSNP
rs951980214 1802 dbSNP
rs1228098662 1807 dbSNP
rs1271374965 1809 dbSNP
rs916216959 1811 dbSNP
rs1194803910 1815 dbSNP
rs990431198 1820 dbSNP
rs181062822 1824 dbSNP
rs1267236223 1829 dbSNP
rs932081330 1833 dbSNP
rs1034775657 1837 dbSNP
rs1194521835 1838 dbSNP
rs915311571 1847 dbSNP
rs1375354597 1863 dbSNP
rs1456649140 1863 dbSNP
rs189656783 1866 dbSNP
rs1167458975 1868 dbSNP
rs1366394250 1875 dbSNP
rs966872254 1876 dbSNP
rs1426825950 1880 dbSNP
rs139874110 1890 dbSNP
rs61480664 1890 dbSNP
rs200882103 1891 dbSNP
rs370872500 1894 dbSNP
rs557611644 1899 dbSNP
rs1297637600 1902 dbSNP
rs1324663216 1910 dbSNP
rs924164883 1918 dbSNP
rs982349334 1921 dbSNP
rs1361088462 1937 dbSNP
rs1243334286 1938 dbSNP
rs1289959731 1939 dbSNP
rs561618728 1940 dbSNP
rs1473363337 1942 dbSNP
rs1250878697 1950 dbSNP
rs1264451337 1958 dbSNP
rs1445815692 1975 dbSNP
rs1208876018 1977 dbSNP
rs1487350779 1979 dbSNP
rs548196209 1983 dbSNP
rs1385967707 1986 dbSNP
rs1446612597 1995 dbSNP
rs901203221 1996 dbSNP
rs1267019528 2003 dbSNP
rs991568407 2006 dbSNP
rs1454112246 2016 dbSNP
rs537611143 2016 dbSNP
rs1214211616 2021 dbSNP
rs1290451642 2022 dbSNP
rs958448579 2025 dbSNP
rs1328455163 2026 dbSNP
rs1382637863 2036 dbSNP
rs940102614 2040 dbSNP
rs1027830800 2045 dbSNP
rs1286515250 2055 dbSNP
rs772998874 2056 dbSNP
rs8083543 2058 dbSNP
rs866068833 2063 dbSNP
rs1300774325 2064 dbSNP
rs1208665341 2065 dbSNP
rs1243757494 2067 dbSNP
rs1385329508 2067 dbSNP
rs376335561 2068 dbSNP
rs576679075 2071 dbSNP
rs148001344 2075 dbSNP
rs890406621 2080 dbSNP
rs990738220 2083 dbSNP
rs754368914 2085 dbSNP
rs1452882962 2095 dbSNP
rs1050408404 2096 dbSNP
rs1408284095 2106 dbSNP
rs939014603 2108 dbSNP
rs1454833093 2114 dbSNP
rs1363894143 2116 dbSNP
rs9959403 2122 dbSNP
rs893860498 2130 dbSNP
rs574907838 2147 dbSNP
rs186857565 2152 dbSNP
rs1392796899 2159 dbSNP
rs1269172447 2163 dbSNP
rs966881235 2164 dbSNP
rs1334361447 2166 dbSNP
rs1228239314 2167 dbSNP
rs935432705 2173 dbSNP
rs1264293983 2178 dbSNP
rs1326347860 2179 dbSNP
rs1201806135 2182 dbSNP
rs1255509102 2188 dbSNP
rs35530947 2194 dbSNP
rs1022433763 2196 dbSNP
rs924099694 2198 dbSNP
rs1046641818 2212 dbSNP
rs1179171802 2224 dbSNP
rs989635594 2225 dbSNP
rs949625940 2231 dbSNP
rs780423229 2234 dbSNP
rs112803501 2236 dbSNP
rs1351430310 2238 dbSNP
rs991142810 2244 dbSNP
rs1175026462 2246 dbSNP
rs1255518643 2249 dbSNP
rs998445306 2250 dbSNP
rs1231300882 2253 dbSNP
rs1296092595 2266 dbSNP
rs958634426 2270 dbSNP
rs535095829 2271 dbSNP
rs4494640 2273 dbSNP
rs1409581892 2277 dbSNP
rs1304609808 2278 dbSNP
rs973112898 2283 dbSNP
rs961803471 2287 dbSNP
rs1363477562 2298 dbSNP
rs1222232993 2308 dbSNP
rs1323075863 2311 dbSNP
rs558954021 2312 dbSNP
rs888514044 2314 dbSNP
rs746326298 2315 dbSNP
rs954614225 2317 dbSNP
rs913753122 2320 dbSNP
rs539344753 2321 dbSNP
rs558256407 2327 dbSNP
rs112651420 2328 dbSNP
rs893778529 2331 dbSNP
rs1464216777 2334 dbSNP
rs1396575994 2338 dbSNP
rs1173877704 2339 dbSNP
rs1054933003 2340 dbSNP
rs939268477 2341 dbSNP
rs1053822823 2343 dbSNP
rs999609731 2344 dbSNP
rs1245986112 2346 dbSNP
rs978176966 2353 dbSNP
rs945092399 2361 dbSNP
rs1195187702 2363 dbSNP
rs1293442057 2365 dbSNP
rs879922057 2366 dbSNP
rs866168201 2368 dbSNP
rs536430256 2369 dbSNP
rs1341663317 2370 dbSNP
rs1247008779 2371 dbSNP
rs914957705 2379 dbSNP
rs902604913 2384 dbSNP
rs954158838 2401 dbSNP
rs1046569470 2407 dbSNP
rs1347395064 2409 dbSNP
rs567818285 2410 dbSNP
rs1184221198 2417 dbSNP
rs966028038 2418 dbSNP
rs754116665 2420 dbSNP
rs895377488 2423 dbSNP
rs1015875087 2425 dbSNP
rs1340424838 2429 dbSNP
rs1403930624 2432 dbSNP
rs1406509329 2435 dbSNP
rs1164563680 2438 dbSNP
rs764278427 2442 dbSNP
rs888493042 2449 dbSNP
rs1433527891 2450 dbSNP
rs181653363 2451 dbSNP
rs1364555419 2452 dbSNP
rs1012962676 2453 dbSNP
rs59454959 2454 dbSNP
rs973081629 2455 dbSNP
rs1054905151 2457 dbSNP
rs1318589185 2457 dbSNP
rs939256065 2457 dbSNP
rs1247412524 2464 dbSNP
rs940405175 2466 dbSNP
rs907638104 2474 dbSNP
rs906431322 2478 dbSNP
rs987291131 2481 dbSNP
rs954717899 2486 dbSNP
rs1472274754 2494 dbSNP
rs1162997798 2495 dbSNP
rs1042332581 2503 dbSNP
rs1402892320 2505 dbSNP
rs1157568969 2518 dbSNP
rs1028847519 2519 dbSNP
rs975059959 2527 dbSNP
rs1338834713 2530 dbSNP
rs958022011 2534 dbSNP
rs796644135 2535 dbSNP
rs539957244 2545 dbSNP
rs1388054887 2548 dbSNP
rs1169481409 2552 dbSNP
rs902571143 2554 dbSNP
rs1324256705 2555 dbSNP
rs117326003 2556 dbSNP
rs1013695251 2560 dbSNP
rs1441415616 2561 dbSNP
rs1182097276 2565 dbSNP
rs1234310425 2566 dbSNP
rs1053491658 2571 dbSNP
rs190378951 2572 dbSNP
rs921404119 2581 dbSNP
rs1055330240 2583 dbSNP
rs977311930 2590 dbSNP
rs563417228 2592 dbSNP
rs908783365 2594 dbSNP
rs1414039902 2596 dbSNP
rs1482220707 2605 dbSNP
rs983090403 2614 dbSNP
rs952789535 2615 dbSNP
rs1407743707 2628 dbSNP
rs7964 2652 dbSNP
rs898754098 2654 dbSNP
rs1037294588 2670 dbSNP
rs574570079 2671 dbSNP
rs561104959 2672 dbSNP
rs541549024 2674 dbSNP
rs907605299 2682 dbSNP
rs987605522 2684 dbSNP
rs572526926 2691 dbSNP
rs1356094117 2692 dbSNP
rs1282877204 2700 dbSNP
rs1247654473 2706 dbSNP
rs1035767890 2710 dbSNP
rs1356770899 2714 dbSNP
rs752018785 2720 dbSNP
rs79386122 2726 dbSNP
rs1202215973 2728 dbSNP
rs974607502 2732 dbSNP
rs764628933 2734 dbSNP
rs1368380732 2738 dbSNP
rs1428099028 2740 dbSNP
rs764349287 2752 dbSNP
rs906407729 2754 dbSNP
rs1410258770 2761 dbSNP
rs1389765218 2764 dbSNP
rs1042663194 2767 dbSNP
rs957909824 2768 dbSNP
rs1271449633 2784 dbSNP
rs1032276460 2785 dbSNP
rs978063080 2792 dbSNP
rs966682730 2798 dbSNP
rs1292131929 2800 dbSNP
rs539025482 2802 dbSNP
rs759006742 2815 dbSNP
rs545053977 2820 dbSNP
rs893450482 2822 dbSNP
rs184884144 2832 dbSNP
rs1243924560 2833 dbSNP
rs932334371 2836 dbSNP
rs1014080447 2838 dbSNP
rs895271001 2842 dbSNP
rs920995713 2847 dbSNP
rs1205500534 2851 dbSNP
rs556600549 2853 dbSNP
rs536916673 2859 dbSNP
rs866922611 2867 dbSNP
rs1288205530 2873 dbSNP
rs1426281524 2877 dbSNP
rs1161293090 2880 dbSNP
rs1216060971 2882 dbSNP
rs1382737265 2884 dbSNP
rs1319639061 2885 dbSNP
rs767297067 2887 dbSNP
rs1362415107 2889 dbSNP
rs147599766 2892 dbSNP
rs774282439 2894 dbSNP
rs117862091 2897 dbSNP
rs1004443215 2902 dbSNP
rs534457262 2908 dbSNP
rs1264087979 2914 dbSNP
rs3752069 2916 dbSNP
rs1266218510 2925 dbSNP
rs141418719 2931 dbSNP
rs1270639160 2937 dbSNP
rs1351220110 2940 dbSNP
rs991438482 2941 dbSNP
rs773035681 2942 dbSNP
rs1330261990 2944 dbSNP
rs138495480 2949 dbSNP
rs1039253433 2951 dbSNP
rs1321391606 2956 dbSNP
rs769598669 2964 dbSNP
rs1462931370 2967 dbSNP
rs1395211314 2972 dbSNP
rs925132483 2981 dbSNP
rs977991030 2986 dbSNP
rs966651675 2998 dbSNP
rs1454193020 3001 dbSNP
rs917907556 3014 dbSNP
rs970926992 3034 dbSNP
rs1410280718 3036 dbSNP
rs1336847502 3037 dbSNP
rs188099016 3041 dbSNP
rs959686366 3045 dbSNP
rs549825712 3048 dbSNP
rs59267293 3053 dbSNP
rs183828738 3058 dbSNP
rs541225105 3064 dbSNP
rs1015743570 3067 dbSNP
rs527827952 3071 dbSNP
rs373441047 3072 dbSNP
rs565363105 3078 dbSNP
rs1041160116 3081 dbSNP
rs1051833894 3084 dbSNP
rs775728401 3088 dbSNP
rs1409603984 3089 dbSNP
rs1300968524 3093 dbSNP
rs112586089 3094 dbSNP
rs900226956 3100 dbSNP
rs1464156766 3103 dbSNP
rs576374571 3108 dbSNP
rs568651790 3111 dbSNP
rs556480251 3112 dbSNP
rs936436686 3114 dbSNP
rs770512707 3115 dbSNP
rs151251948 3125 dbSNP
rs945234738 3134 dbSNP
rs917847823 3137 dbSNP
rs928654240 3148 dbSNP
rs1314008383 3151 dbSNP
rs981907397 3152 dbSNP
rs992538167 3153 dbSNP
rs959417395 3160 dbSNP
rs1249357158 3164 dbSNP
rs142303597 3166 dbSNP
rs1200045374 3178 dbSNP
rs779461163 3179 dbSNP
rs1454935884 3183 dbSNP
rs1174802218 3186 dbSNP
rs1373236568 3188 dbSNP
rs79009104 3195 dbSNP
rs749336429 3217 dbSNP
rs1015676751 3219 dbSNP
rs1004346662 3220 dbSNP
rs1409658474 3233 dbSNP
rs1032251999 3240 dbSNP
rs1370427077 3242 dbSNP
rs1217503661 3252 dbSNP
rs1300718884 3253 dbSNP
rs1308234328 3254 dbSNP
rs116151325 3256 dbSNP
rs1029933098 3266 dbSNP
rs1272828155 3276 dbSNP
rs1341192078 3298 dbSNP
rs565463447 3305 dbSNP
rs1248362344 3313 dbSNP
rs565677813 3313 dbSNP
rs997533118 3318 dbSNP
rs558254864 3319 dbSNP
rs1190081011 3331 dbSNP
rs1059474 3338 dbSNP
rs1019296974 3339 dbSNP
rs1450880105 3351 dbSNP
rs1277676120 3353 dbSNP
rs1236064313 3354 dbSNP
rs1429492464 3359 dbSNP
rs1348271999 3367 dbSNP
rs1296648837 3407 dbSNP
rs1352085635 3412 dbSNP
rs538696084 3413 dbSNP
rs879113237 3421 dbSNP
rs470871 3422 dbSNP
rs886850107 3429 dbSNP
rs1447302097 3447 dbSNP
rs1362736514 3455 dbSNP
rs1000617136 3463 dbSNP
rs60084519 3464 dbSNP
rs147823171 3475 dbSNP
rs1435607347 3483 dbSNP
rs1364794194 3492 dbSNP
rs1246376017 3503 dbSNP
rs865787546 3508 dbSNP
rs1042210031 3510 dbSNP
rs898703422 3522 dbSNP
rs1319784805 3524 dbSNP
rs775190190 3524 dbSNP
rs945203117 3543 dbSNP
rs567544412 3545 dbSNP
rs1056365589 3546 dbSNP
rs1430799563 3549 dbSNP
rs547646474 3563 dbSNP
rs1416434046 3565 dbSNP
rs919140758 3567 dbSNP
rs937611535 3573 dbSNP
rs144451854 3574 dbSNP
rs926635135 3588 dbSNP
rs1482614994 3603 dbSNP
rs2282557 3604 dbSNP
rs1212537718 3606 dbSNP
rs1318645453 3614 dbSNP
rs946061816 3619 dbSNP
rs1449032225 3631 dbSNP
rs754801383 3641 dbSNP
rs913313272 3643 dbSNP
rs1376680615 3644 dbSNP
rs545527734 3653 dbSNP
rs1273632733 3660 dbSNP
rs908646503 3666 dbSNP
rs1202263682 3668 dbSNP
rs1331174617 3669 dbSNP
rs1309045443 3670 dbSNP
rs76872033 3674 dbSNP
rs982889789 3678 dbSNP
rs1296140753 3687 dbSNP
rs955548930 3689 dbSNP
rs1032181371 3690 dbSNP
rs1030274386 3693 dbSNP
rs1471997715 3700 dbSNP
rs12406 3701 dbSNP
rs1156948172 3703 dbSNP
rs1388015052 3704 dbSNP
rs1415166678 3713 dbSNP
rs964686830 3717 dbSNP
rs964007093 3723 dbSNP
rs1446984366 3726 dbSNP
rs1019978816 3727 dbSNP
rs1007877237 3731 dbSNP
rs1017242908 3732 dbSNP
rs1000540340 3735 dbSNP
rs192844736 3740 dbSNP
rs1323621760 3745 dbSNP
rs1020733450 3747 dbSNP
rs1220493306 3749 dbSNP
rs1276043825 3754 dbSNP
rs1296808130 3759 dbSNP
rs1209804763 3765 dbSNP
rs112470302 3776 dbSNP
rs1463796654 3788 dbSNP
rs1484288550 3802 dbSNP
rs1453570118 3812 dbSNP
rs995227332 3814 dbSNP
rs766383268 3816 dbSNP
rs1478377435 3820 dbSNP
rs1174435685 3821 dbSNP
rs1423282012 3822 dbSNP
rs1164637589 3827 dbSNP
rs1422620189 3839 dbSNP
rs1055900269 3841 dbSNP
rs542995864 3848 dbSNP
rs937939586 3851 dbSNP
rs1372166279 3855 dbSNP
rs905117246 3860 dbSNP
rs1038305220 3866 dbSNP
rs1307304780 3868 dbSNP
rs373243728 3880 dbSNP
rs941384591 3881 dbSNP
rs1250525740 3882 dbSNP
rs907432201 3886 dbSNP
rs762940425 3898 dbSNP
rs1481466277 3905 dbSNP
rs749972351 3917 dbSNP
rs982819230 3922 dbSNP
rs1228700876 3934 dbSNP
rs554018699 3945 dbSNP
rs1344747470 3954 dbSNP
rs551814816 3961 dbSNP
rs1251694922 3966 dbSNP
rs140590290 3971 dbSNP
rs1332652910 3972 dbSNP
rs1245071128 3973 dbSNP
rs1477775780 3975 dbSNP
rs1169465971 3985 dbSNP
rs1392301888 3994 dbSNP
rs1275116907 4007 dbSNP
rs913231058 4016 dbSNP
rs964291720 4020 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.664 2.8e-4 0.447 1.6e-2 23 Click to see details
GSE28544 Breast cancer -0.45 1.4e-2 -0.490 7.5e-3 24 Click to see details
GSE19783 ER+ ER+ breast cancer 0.399 4.1e-2 0.385 4.7e-2 20 Click to see details
GSE38226 Liver fibrosis -0.254 1.3e-1 -0.281 1.1e-1 21 Click to see details
GSE19536 Breast cancer 0.112 1.3e-1 0.106 1.5e-1 100 Click to see details
GSE19350 CNS germ cell tumors -0.318 1.6e-1 -0.049 4.4e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.202 1.7e-1 0.287 8.2e-2 25 Click to see details
GSE26953 Aortic valvular endothelial cells 0.14 2.6e-1 0.182 2.0e-1 24 Click to see details
GSE17498 Multiple myeloma -0.091 2.9e-1 -0.039 4.1e-1 40 Click to see details
GSE21687 Ependynoma primary tumors 0.047 3.6e-1 -0.028 4.1e-1 64 Click to see details
GSE19783 ER- ER- breast cancer -0.034 3.8e-1 -0.049 3.3e-1 79 Click to see details
GSE28260 Renal cortex and medulla -0.023 4.7e-1 -0.198 2.6e-1 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.016 4.7e-1 -0.465 1.9e-2 20 Click to see details
GSE32688 Pancreatic cancer -0.007 4.8e-1 -0.005 4.9e-1 32 Click to see details
GSE32688 Pancreatic cancer -0.007 4.8e-1 -0.005 4.9e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.389 0.01 -0.353 0.01 38 Click to see details
THCA 0.255 0.03 0.318 0.01 59 Click to see details
COAD -0.659 0.04 -0.524 0.09 8 Click to see details
KIRC -0.18 0.07 -0.193 0.06 68 Click to see details
HNSC 0.2 0.1 0.139 0.19 42 Click to see details
BLCA 0.292 0.12 0.340 0.08 18 Click to see details
PCPG 0.859 0.17 1.000 0.5 3 Click to see details
CHOL 0.318 0.2 0.333 0.19 9 Click to see details
KIRP 0.147 0.21 0.093 0.31 32 Click to see details
LUAD 0.199 0.27 0.364 0.12 12 Click to see details
BRCA 0.062 0.29 0.054 0.31 84 Click to see details
LIHC -0.072 0.31 -0.041 0.39 49 Click to see details
UCEC -0.112 0.32 -0.181 0.23 19 Click to see details
ESCA -0.122 0.36 -0.145 0.34 11 Click to see details
PAAD -0.188 0.41 0.400 0.3 4 Click to see details
PRAD 0.024 0.43 0.088 0.27 50 Click to see details
STAD -0.029 0.44 -0.324 0.04 32 Click to see details
CESC -0.175 0.44 -0.500 0.33 3 Click to see details
KICH -0.003 0.49 -0.035 0.43 25 Click to see details
KICH -0.003 0.49 -0.035 0.43 25 Click to see details
KICH -0.003 0.49 -0.035 0.43 25 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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