miRTarBase - #MIRT440397


—
pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KDM6B   
Synonyms JMJD3
Description lysine demethylase 6B
Transcript NM_001080424   
Expression
Putative miRNA Targets on KDM6B
3'UTR of KDM6B
(miRNA target sites are highlighted)		 
>KDM6B|NM_001080424|3'UTR
   1 GGCCGGACGCCCCGCCCGCCTGCCTGCCCGCGCAAGGCGCCGCGGGGCCACCAGCACATGCCTGGGCTGGACCTAGGTCC
  81 CGCCTGTGGCCGAGAAGGGGGTCGGGCCCAGCCCTTCCACCCCATTGGCAGCTCCCCTCACTTAATTTATTAAGAAAAAC
 161 TTTTTTTTTTTTTTTAGCAAATATGAGGAAAAAAGGAAAAAAAATGGGAGACGGGGGAGGGGGCTGGCAGCCCCTCGCCC
 241 ACCAGCGCCTCCCCTCACCGACTTTGGCCTTTTTAGCAACAGACACAAGGACCAGGCTCCGGCGGCGGCGGGGGTCACAT
 321 ACGGGTTCCCTCACCCTGCCAGCCGCCCGCCCGCCCGGCGCAGATGCACGCGGCTCGTGTATGTACATAGACGTTACGGC
 401 AGCCGAGGTTTTTAATGAGATTCTTTCTATGGGCTTTACCCCTCCCCCGGAACCTCCTTTTTTACTTCCAATGCTAGCTG
 481 TGACCCCTGTACATGTCTCTTTATTCACTTGGTTATGATTTGTATTTTTTGTTCTTTTCTTGTTTTTTTGTTTTTAATTT
 561 ATAACAGTCCCACTCACCTCTATTTATTCATTTTTGGGAAAACCCGACCTCCCACACCCCCAAGCCATCCTGCCCGCCCC
 641 TCCAGGGACCGCCCGTCGCCGGGCTCTCCCCGCGCCCCAGTGTGTGTCCGGGCCCGGCCCGACCGTCTCCACCCGTCCGC
 721 CCGCGGCTCCAGCCGGGTTCTCATGGTGCTCAAACCCGCTCCCCTCCCCTACGTCCTGCACTTTCTCGGACCAGTCCCCC
 801 CACTCCCGACCCGACCCCAGCCCCACCTGAGGGTGAGCAACTCCTGTACTGTAGGGGAAGAAGTGGGAACTGAAATGGTA
 881 TTTTGTAAAAAAAATAAATAAAATAAAAAAATTAAAGGTTTTAAAGAAAGAACTATGAGGAAAAGGAACCCCGTCCTTCC
 961 CAGCCCCGGCCAACTTTAAAAAACACAGACCTTCACCCCCACCCCCTTTTCTTTTTAAGTGTGAAACAACCCAGGGCCAG
1041 GGCCTCACTGGGGCAGGGACACCCCGGGGTGAGTTTCTCTGGGGCTTTATTTTCGTTTTGTTGGTTGTTTTTTCTCCACG
1121 CTGGGGCTGCGGAGGGGTGGGGGGTTTACAGTCCCGCACCCTCGCACTGCACTGTCTCTCTGCCCCAGGGGCAGAGGGGT
1201 CTTCCCAACCCTACCCCTATTTTCGGTGATTTTTGTGTGAGAATATTAATATTAAAAATAAACGGAGAAAAAAAAAAAAA
1281 AAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaguCUC-GGGAGA-CUCGAAGUc 5'
              ||| ::|||| |:||||:| 
Target 5' gggtGAGTTTCTCTGGGGCTTTAt 3'
 1067 - 1090 134.00 -15.60
2 
miRNA  3' uagUCUCGG---GAGACUCGAAGUc 5'
             ||| :|   || ||:||||:| 
Target 5' atgAGATTCTTTCTATGGGCTTTAc 3'
 415 - 439 131.00 -12.50
3 
miRNA  3' uagucucggGAGACUCGAAGUc 5'
                   | | || ||||| 
Target 5' tttaaaaaaCACAGACCTTCAc 3'
 975 - 996 117.00 -9.01
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN22624883 45 COSMIC
COSN26537747 61 COSMIC
COSN20113478 176 COSMIC
COSN26586750 214 COSMIC
COSN26578266 296 COSMIC
COSN31491167 394 COSMIC
COSN31531924 441 COSMIC
COSN25753379 617 COSMIC
COSN7456583 634 COSMIC
COSN31564345 724 COSMIC
COSN31538934 758 COSMIC
COSN26565104 847 COSMIC
COSN24306189 850 COSMIC
COSN20113482 895 COSMIC
COSN25422598 1088 COSMIC
COSN31518559 1120 COSMIC
rs112843870 888 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1296947477 6 dbSNP
rs1364513855 8 dbSNP
rs1383059350 9 dbSNP
rs1017323151 14 dbSNP
rs1462539293 15 dbSNP
rs890310537 16 dbSNP
rs753721931 18 dbSNP
rs757314591 18 dbSNP
rs1292548641 19 dbSNP
rs1009134139 22 dbSNP
rs1214344661 24 dbSNP
rs374683893 30 dbSNP
rs967506082 32 dbSNP
rs767093904 33 dbSNP
rs1338120330 36 dbSNP
rs1249147671 37 dbSNP
rs1253848655 39 dbSNP
rs1425148622 42 dbSNP
rs1183867205 43 dbSNP
rs1379136185 44 dbSNP
rs1437348572 47 dbSNP
rs1359690522 49 dbSNP
rs754774343 53 dbSNP
rs544770538 57 dbSNP
rs1314008049 58 dbSNP
rs1337361103 60 dbSNP
rs1450145974 60 dbSNP
rs1329396466 82 dbSNP
rs1032643940 83 dbSNP
rs1166241535 85 dbSNP
rs1426691710 92 dbSNP
rs59129736 95 dbSNP
rs1386093454 98 dbSNP
rs1443144090 100 dbSNP
rs1232933013 104 dbSNP
rs958359360 105 dbSNP
rs1437764616 106 dbSNP
rs1249106069 107 dbSNP
rs1490382016 110 dbSNP
rs1290554337 115 dbSNP
rs991095804 119 dbSNP
rs1039953391 120 dbSNP
rs1279925464 123 dbSNP
rs563197638 124 dbSNP
rs533633614 126 dbSNP
rs1333897103 127 dbSNP
rs1304954657 128 dbSNP
rs1406817027 129 dbSNP
rs1366330170 134 dbSNP
rs778832032 136 dbSNP
rs1346309322 137 dbSNP
rs1221496831 138 dbSNP
rs1470005901 140 dbSNP
rs970936149 140 dbSNP
rs552080857 142 dbSNP
rs921068631 155 dbSNP
rs1464768742 160 dbSNP
rs1284587373 161 dbSNP
rs35202212 161 dbSNP
rs907957524 161 dbSNP
rs397822445 176 dbSNP
rs1209543054 177 dbSNP
rs1224075722 178 dbSNP
rs539430814 179 dbSNP
rs551546588 184 dbSNP
rs1346187604 185 dbSNP
rs940739533 186 dbSNP
rs569710071 187 dbSNP
rs1467144294 191 dbSNP
rs1198272952 194 dbSNP
rs28562210 196 dbSNP
rs1247426729 197 dbSNP
rs1347176132 197 dbSNP
rs28738673 198 dbSNP
rs1400468081 205 dbSNP
rs538087222 206 dbSNP
rs1037741428 207 dbSNP
rs528079939 210 dbSNP
rs1196627190 211 dbSNP
rs1476148349 213 dbSNP
rs1242310675 215 dbSNP
rs1192094110 218 dbSNP
rs1478967568 227 dbSNP
rs920634331 229 dbSNP
rs931964059 237 dbSNP
rs1261244395 241 dbSNP
rs1156790603 245 dbSNP
rs964367876 248 dbSNP
rs1410887497 252 dbSNP
rs1457597479 254 dbSNP
rs1270941271 260 dbSNP
rs1050329708 261 dbSNP
rs890341021 262 dbSNP
rs1339115322 277 dbSNP
rs1008749154 278 dbSNP
rs1405984460 279 dbSNP
rs1174627342 282 dbSNP
rs1411134973 285 dbSNP
rs1041901872 291 dbSNP
rs1166922550 292 dbSNP
rs1391854911 293 dbSNP
rs755846264 300 dbSNP
rs1183957263 306 dbSNP
rs11553166 308 dbSNP
rs1241172167 310 dbSNP
rs920491549 311 dbSNP
rs1309291909 312 dbSNP
rs568098740 313 dbSNP
rs1032745320 318 dbSNP
rs1340281759 319 dbSNP
rs1332360712 322 dbSNP
rs1453800210 324 dbSNP
rs1439196951 329 dbSNP
rs1053574343 334 dbSNP
rs958388971 336 dbSNP
rs1445035804 341 dbSNP
rs950600074 342 dbSNP
rs1012559584 343 dbSNP
rs1023913676 343 dbSNP
rs971350263 347 dbSNP
rs1443729088 353 dbSNP
rs1411395792 355 dbSNP
rs982312444 357 dbSNP
rs1232287267 358 dbSNP
rs983653993 360 dbSNP
rs535309931 361 dbSNP
rs1294195166 368 dbSNP
rs1332946215 369 dbSNP
rs928053261 371 dbSNP
rs962231959 372 dbSNP
rs1359125402 373 dbSNP
rs1311041098 375 dbSNP
rs939475790 377 dbSNP
rs1374674433 388 dbSNP
rs1470493662 389 dbSNP
rs1290650192 392 dbSNP
rs920664108 393 dbSNP
rs200781658 394 dbSNP
rs1303338787 395 dbSNP
rs1423610394 404 dbSNP
rs1055125141 408 dbSNP
rs892197667 410 dbSNP
rs1160997224 414 dbSNP
rs1009212217 415 dbSNP
rs1411913190 417 dbSNP
rs556700772 424 dbSNP
rs1407117394 427 dbSNP
rs1250990962 428 dbSNP
rs1179990065 429 dbSNP
rs568692604 430 dbSNP
rs1271185427 438 dbSNP
rs1184061745 442 dbSNP
rs946687905 443 dbSNP
rs1488286691 444 dbSNP
rs143082103 446 dbSNP
rs1263958950 450 dbSNP
rs1218380894 452 dbSNP
rs1317941986 455 dbSNP
rs1306849922 469 dbSNP
rs1227122703 470 dbSNP
rs575055340 472 dbSNP
rs1041626553 474 dbSNP
rs1283382336 475 dbSNP
rs1415483477 476 dbSNP
rs148209702 479 dbSNP
rs1365042174 481 dbSNP
rs1000018764 483 dbSNP
rs1454099831 485 dbSNP
rs1054219376 486 dbSNP
rs1156813742 487 dbSNP
rs902735650 488 dbSNP
rs1431472307 489 dbSNP
rs1306649638 494 dbSNP
rs1350428786 497 dbSNP
rs999707285 498 dbSNP
rs1051225741 499 dbSNP
rs186639406 502 dbSNP
rs73977769 508 dbSNP
rs1188559482 509 dbSNP
rs1486373785 512 dbSNP
rs971081243 520 dbSNP
rs1017354392 521 dbSNP
rs1207320219 525 dbSNP
rs1244268277 525 dbSNP
rs1326257187 529 dbSNP
rs1264374963 531 dbSNP
rs1004239909 532 dbSNP
rs1358474951 535 dbSNP
rs964398910 537 dbSNP
rs1015156831 538 dbSNP
rs994889805 539 dbSNP
rs555584481 540 dbSNP
rs147813431 543 dbSNP
rs1406727676 545 dbSNP
rs950650282 545 dbSNP
rs1207258167 551 dbSNP
rs1255109969 557 dbSNP
rs1423050896 558 dbSNP
rs574052389 562 dbSNP
rs1175669443 565 dbSNP
rs544834542 566 dbSNP
rs1027713329 568 dbSNP
rs1369844679 569 dbSNP
rs1172715752 570 dbSNP
rs553761392 571 dbSNP
rs1429350345 578 dbSNP
rs191438558 581 dbSNP
rs1462965948 586 dbSNP
rs1474109468 590 dbSNP
rs983382961 597 dbSNP
rs1046021424 603 dbSNP
rs1200404030 604 dbSNP
rs1167403883 605 dbSNP
rs563109395 606 dbSNP
rs1370714187 607 dbSNP
rs960514294 610 dbSNP
rs944707317 615 dbSNP
rs906806890 617 dbSNP
rs578214690 618 dbSNP
rs990887082 619 dbSNP
rs916640066 620 dbSNP
rs1310408689 621 dbSNP
rs1054253850 626 dbSNP
rs758253355 637 dbSNP
rs1299950632 645 dbSNP
rs1462620817 648 dbSNP
rs1400460017 652 dbSNP
rs946750862 655 dbSNP
rs1386283858 656 dbSNP
rs1313634607 664 dbSNP
rs1441206433 665 dbSNP
rs1044084077 670 dbSNP
rs1253355534 671 dbSNP
rs1342472318 672 dbSNP
rs182807741 673 dbSNP
rs906885927 678 dbSNP
rs1224282270 680 dbSNP
rs1359800927 680 dbSNP
rs1283393317 681 dbSNP
rs560795973 682 dbSNP
rs528076978 686 dbSNP
rs370441062 689 dbSNP
rs1230458007 690 dbSNP
rs1307666391 691 dbSNP
rs1410491430 692 dbSNP
rs1370051946 693 dbSNP
rs1415645334 693 dbSNP
rs1015602413 695 dbSNP
rs898056155 696 dbSNP
rs1163028598 697 dbSNP
rs1472053157 698 dbSNP
rs924219466 699 dbSNP
rs546545286 700 dbSNP
rs373980193 701 dbSNP
rs1258081782 702 dbSNP
rs1249027035 704 dbSNP
rs1002377042 712 dbSNP
rs1444922357 717 dbSNP
rs1224178298 720 dbSNP
rs1490406834 721 dbSNP
rs1207808186 723 dbSNP
rs1288783648 723 dbSNP
rs1051340933 724 dbSNP
rs891330336 725 dbSNP
rs994967987 728 dbSNP
rs1286548725 729 dbSNP
rs1406907835 732 dbSNP
rs1027744423 735 dbSNP
rs1007046154 736 dbSNP
rs1170953540 741 dbSNP
rs1403936078 744 dbSNP
rs1038822795 745 dbSNP
rs1466027693 752 dbSNP
rs1303785852 755 dbSNP
rs561641238 758 dbSNP
rs986217270 759 dbSNP
rs1457187566 761 dbSNP
rs1410468716 764 dbSNP
rs528986286 765 dbSNP
rs1480498829 768 dbSNP
rs1245748245 770 dbSNP
rs1448475909 773 dbSNP
rs550241844 773 dbSNP
rs966454515 778 dbSNP
rs1207971277 782 dbSNP
rs1265003731 794 dbSNP
rs1326981045 794 dbSNP
rs977425550 797 dbSNP
rs1345871480 801 dbSNP
rs924526415 802 dbSNP
rs935871781 803 dbSNP
rs1321626126 809 dbSNP
rs1027770607 810 dbSNP
rs950403676 812 dbSNP
rs1414493042 813 dbSNP
rs1437375858 814 dbSNP
rs990060704 818 dbSNP
rs1005235452 821 dbSNP
rs753895277 821 dbSNP
rs1034880558 823 dbSNP
rs796217721 829 dbSNP
rs960546567 833 dbSNP
rs1463409428 835 dbSNP
rs1233967641 843 dbSNP
rs1244874044 844 dbSNP
rs1204252524 845 dbSNP
rs1443037640 845 dbSNP
rs572150707 846 dbSNP
rs1257513222 857 dbSNP
rs1023683192 861 dbSNP
rs1228092707 870 dbSNP
rs1207664391 873 dbSNP
rs188228843 886 dbSNP
rs112843870 887 dbSNP
rs34157498 887 dbSNP
rs397817394 887 dbSNP
rs906920626 887 dbSNP
rs577422500 892 dbSNP
rs939697662 892 dbSNP
rs898090231 893 dbSNP
rs1386898783 895 dbSNP
rs1447387341 895 dbSNP
rs1472436050 896 dbSNP
rs746433772 896 dbSNP
rs1235728185 897 dbSNP
rs1208068475 899 dbSNP
rs1027858687 900 dbSNP
rs1275555882 903 dbSNP
rs1204741038 904 dbSNP
rs1266134810 905 dbSNP
rs889312193 906 dbSNP
rs1229309930 909 dbSNP
rs1282985466 910 dbSNP
rs1379077713 910 dbSNP
rs1443715375 912 dbSNP
rs1177486298 918 dbSNP
rs1370664437 920 dbSNP
rs1306985254 923 dbSNP
rs756911866 923 dbSNP
rs368100502 926 dbSNP
rs1165208529 936 dbSNP
rs923972752 937 dbSNP
rs1411499550 941 dbSNP
rs1423065907 941 dbSNP
rs1158621508 954 dbSNP
rs935334148 961 dbSNP
rs1019466700 964 dbSNP
rs1389679932 969 dbSNP
rs1181656791 971 dbSNP
rs564453391 972 dbSNP
rs1482188429 973 dbSNP
rs11553167 975 dbSNP
rs1437620514 983 dbSNP
rs558592456 997 dbSNP
rs987075821 1000 dbSNP
rs1367049980 1001 dbSNP
rs999271848 1002 dbSNP
rs1031707610 1004 dbSNP
rs1288292670 1006 dbSNP
rs1226013274 1007 dbSNP
rs1350501832 1010 dbSNP
rs539241061 1012 dbSNP
rs1387259732 1021 dbSNP
rs4791855 1030 dbSNP
rs942861900 1031 dbSNP
rs1039864045 1037 dbSNP
rs898658883 1046 dbSNP
rs930420967 1047 dbSNP
rs915815816 1051 dbSNP
rs1048788671 1053 dbSNP
rs1161114501 1056 dbSNP
rs1227566694 1057 dbSNP
rs1411225302 1058 dbSNP
rs1158517543 1060 dbSNP
rs1471675663 1061 dbSNP
rs886126069 1063 dbSNP
rs1488338533 1064 dbSNP
rs969890135 1067 dbSNP
rs1211065782 1086 dbSNP
rs1330416969 1089 dbSNP
rs1268588735 1094 dbSNP
rs1268091882 1100 dbSNP
rs1226013810 1104 dbSNP
rs1325094936 1105 dbSNP
rs371945892 1107 dbSNP
rs981273114 1110 dbSNP
rs1034911754 1114 dbSNP
rs896373344 1115 dbSNP
rs566713372 1120 dbSNP
rs1012038050 1121 dbSNP
rs1435627455 1126 dbSNP
rs1387780746 1128 dbSNP
rs1156919126 1131 dbSNP
rs939752765 1132 dbSNP
rs1023929110 1133 dbSNP
rs1192241563 1139 dbSNP
rs967899844 1139 dbSNP
rs1037180680 1145 dbSNP
rs1432838238 1153 dbSNP
rs766375767 1156 dbSNP
rs1031067435 1157 dbSNP
rs1247896108 1160 dbSNP
rs1207420258 1162 dbSNP
rs1483906273 1164 dbSNP
rs919631733 1170 dbSNP
rs533962815 1175 dbSNP
rs1049315571 1178 dbSNP
rs1063746 1181 dbSNP
rs1228840887 1184 dbSNP
rs1318415058 1187 dbSNP
rs1364219125 1187 dbSNP
rs1413249005 1187 dbSNP
rs1454520430 1188 dbSNP
rs751631671 1192 dbSNP
rs1404379031 1196 dbSNP
rs1303488783 1199 dbSNP
rs1458992459 1200 dbSNP
rs986772231 1207 dbSNP
rs912828422 1209 dbSNP
rs1349328902 1211 dbSNP
rs1450430397 1216 dbSNP
rs1389947916 1218 dbSNP
rs1008144152 1219 dbSNP
rs1426059868 1220 dbSNP
rs1040511706 1221 dbSNP
rs902003256 1224 dbSNP
rs1295153761 1225 dbSNP
rs1205469232 1230 dbSNP
rs1341115136 1231 dbSNP
rs754964115 1236 dbSNP
rs1295150759 1244 dbSNP
rs550093679 1249 dbSNP
rs998991081 1252 dbSNP
rs1311977481 1255 dbSNP
rs1031744504 1264 dbSNP
rs1352151277 1267 dbSNP
rs1011553040 1268 dbSNP
rs957388248 1268 dbSNP
rs1430656475 1269 dbSNP
rs1226210124 1273 dbSNP
rs573936345 1276 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease -0.287 8.2e-2 -0.156 2.3e-1 25 Click to see details
GSE28260 Renal cortex and medulla -0.381 9.9e-2 -0.192 2.6e-1 13 Click to see details
GSE19350 CNS germ cell tumors 0.392 1.0e-1 0.441 7.6e-2 12 Click to see details
GSE19783 ER+ ER+ breast cancer -0.25 1.4e-1 -0.281 1.2e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.217 1.5e-1 0.089 3.4e-1 24 Click to see details
GSE28544 Breast cancer 0.208 1.6e-1 0.260 1.1e-1 24 Click to see details
GSE38226 Liver fibrosis 0.214 1.8e-1 0.231 1.6e-1 21 Click to see details
GSE19536 Breast cancer 0.072 2.4e-1 0.067 2.5e-1 100 Click to see details
GSE17498 Multiple myeloma -0.059 3.6e-1 0.032 4.2e-1 40 Click to see details
GSE32688 Pancreatic cancer 0.045 4.0e-1 -0.022 4.5e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.03 4.5e-1 0.316 8.7e-2 20 Click to see details
GSE19783 ER- ER- breast cancer 0.005 4.8e-1 0.073 2.6e-1 79 Click to see details
GSE42095 Differentiated embryonic stem cells -0.008 4.9e-1 -0.021 4.6e-1 23 Click to see details
GSE21687 Ependynoma primary tumors -0.001 5.0e-1 -0.106 2.0e-1 64 Click to see details
GSE21687 Ependynoma primary tumors -0.001 5.0e-1 -0.106 2.0e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.384 0.01 -0.349 0.01 42 Click to see details
LUAD -0.537 0.04 -0.350 0.13 12 Click to see details
COAD 0.514 0.1 0.714 0.02 8 Click to see details
ESCA -0.425 0.1 -0.327 0.16 11 Click to see details
LIHC 0.187 0.1 0.196 0.09 49 Click to see details
CHOL -0.465 0.1 -0.633 0.03 9 Click to see details
LUSC -0.202 0.11 -0.233 0.08 38 Click to see details
KIRP -0.213 0.12 -0.066 0.36 32 Click to see details
BLCA 0.289 0.12 0.354 0.07 18 Click to see details
THCA 0.096 0.23 0.033 0.4 59 Click to see details
PAAD -0.526 0.24 -0.800 0.1 4 Click to see details
CESC 0.617 0.29 0.500 0.33 3 Click to see details
PRAD 0.075 0.3 0.090 0.27 50 Click to see details
PCPG 0.558 0.31 0.500 0.33 3 Click to see details
BRCA 0.05 0.33 0.100 0.18 84 Click to see details
KICH -0.08 0.35 -0.079 0.35 25 Click to see details
STAD -0.056 0.38 -0.110 0.27 32 Click to see details
KIRC 0.013 0.46 -0.020 0.44 68 Click to see details
UCEC 0.025 0.46 0.009 0.49 19 Click to see details
UCEC 0.025 0.46 0.009 0.49 19 Click to see details
UCEC 0.025 0.46 0.009 0.49 19 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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