miRTarBase - #MIRT440411


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KAT2B   
Synonyms CAF, P/CAF, PCAF
Description lysine acetyltransferase 2B
Transcript NM_003884   
Expression
Putative miRNA Targets on KAT2B
3'UTR of KAT2B
(miRNA target sites are highlighted)		 
>KAT2B|NM_003884|3'UTR
   1 TTTTTTTTCCCCTCTGCTTCTTAGAAACTCACCAAGCAGTGTGCCTAAAGCAAGGTGGTTTAGTTTTTTACAAAGAATTG
  81 GACATGATGTATTGAAGAGACTTGTAAATGTAATAATTAGCACTTTTGAAAAAACAAAAAACCTCCTTTTAGCTTTTCAG
 161 ATATGTATTTAAATTGAAGTCATAGGACATTTTTATTTTATGGAATAGATTTTAATCTATTTACTACTATTAAGGTAAAT
 241 TTTCTATGGCATGTCCATTAGCTATTTCATGATAGATGATTAGGGGTTTCCTCAAAACCTGTGTGTGAGGAAATTGCACA
 321 CAGTAGCAAAATTTGGGGAAATCCATAACATTTTCAGACCATGAATGAATGTTTCCATTTTTTTCTAATGGAATGTGAGA
 401 GTTTACTTTTATTTTATTCTGAAGGACTTTAAGGAAGGGATACATGATTTTAAAAAAGCCTGTAAGAGGTGAAATATGTG
 481 ATGTTTGAAGTCTCTTTATAGACTTTTTATATATATTTTTTAAAACACTCATCTAGATGAGGTGCTTTGAGCAGTTCTGA
 561 AAAATGCAGTTCCAGGAAAGCAACTGCTTTGGTTCCTAAGGAAGAAATTCTAAATAATGCAAACTTTTAAAATAAGCATC
 641 TAGGTTTTTGATAATTCTGTCTACTTACAACAAACTTGTTAGTACATAACCACTATTTTAATAATTATTTTCTCTACACA
 721 AATGTGTAATATCATATTTGACTTTGCTTATGCAGGCCATAAGTTCCAAAAGATAATTTCCCTGCCCACAAAGGCATAAA
 801 CTTGAAAACACATGAGATTGAATCAACATGCTTTAATAGGAAAAGATGTATGGTCTATATATGTATCAATCTGGTGAATC
 881 CTCGTTCTAATAAAGGTTCTTTTTCTTTTCTATGATACACACAGCCACGCTGATAATATGCAAATGAACATTTTCCTTTA
 961 TGTCTCTCCAGATAATGTTTATTGTCTGAGGTAAATTAAATTCCCACCAGGGTTTGCTGTCAGTATTTTAACACCCACAT
1041 TAGTATATGCGTCCAGGGTCATAACCCCCTAAAATCCATCATGCAACCTTATTAATCTGTCTTGGGATTCCAGTTTAGTG
1121 CTTGGATTTATTTCCTGATTACACTACATAGAAAAGTGAGACATCTGCCATTCCCAACTCTGGGAAAACCAACTAATATA
1201 CAACCATATAAATGAAGGCCATCTTGATGGTCTCAACACTAATTTTTATGATGCAAATTTATACACTGATTTTTGTAAAG
1281 GACAAAGTTTTAAAAGCGTATTTAACTTGATGTTTTCTATCAGCATAAATAAAATGGTCATGAATAGTCATTAAAAACAG
1361 TTGCCAGTGATAATCTGCATGAAGGAAAAAGAACCCTGCAAATGGCTATTGAGTTGGAAGTATTGTTTTTGATATGTAAG
1441 AGATATTCAGAATGCTCACACTGAAAATGCCTCAACTTTTTAAAGTGTAAGAAACCACCATGAGTGGTGTCTAGATTTCT
1521 AATGAAGAATCATGATACAGTTTGGATTAAGTATCTTGGACTGGTTTTAAACAGTGCTTTGTACCGGATCTGCTGAAGCA
1601 TCTGTCCAGCTGGTATCCTGTGAAAGTTTGTTATTTTCTGAGTAGACATTCTTATAGAGTATTGTCTTTAAAATCAGATT
1681 GTCTCTTCTATATTGAAAGCATTTTTATGTTTTCTAATTTAAAAATTAATATTTTCTTATAGATATTGTGCAATAAAGCT
1761 GAAGTAGAATGTGTGGTTTTTGCAAATGCTTTAACAGCTGATAAAAATTTTACATTTGTAAAATTAATATATTGTACTGG
1841 TACAAAATAGTTTTAAATTATATTTTAAAAAGCTTCCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagucucGGGAGACUCGAAGuc 5'
                 :|||:| |||||:  
Target 5' aaaaaccTCCTTTTAGCTTTtc 3'
 137 - 158 123.00 -11.10
2 
miRNA  3' uagucucgggagacUCGAAGuc 5'
                        ||||||  
Target 5' attatattttaaaaAGCTTCca 3'
 1857 - 1878 120.00 -7.40
3 
miRNA  3' uagucucGGGAGACUCGAAGuc 5'
                 ||||||  |||||  
Target 5' ttttttcCCCTCT--GCTTCtt 3'
 3 - 22 114.00 -14.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15657329 9 COSMIC
COSN17076755 9 COSMIC
COSN20045957 9 COSMIC
COSN30490646 12 COSMIC
COSN30112582 44 COSMIC
COSN31582607 76 COSMIC
COSN31517286 100 COSMIC
COSN30543526 153 COSMIC
COSN31608860 209 COSMIC
COSN24828598 239 COSMIC
COSN31531422 250 COSMIC
COSN23738742 255 COSMIC
COSN31584383 349 COSMIC
COSN30543861 356 COSMIC
COSN30539366 370 COSMIC
COSN31542957 492 COSMIC
COSN31531241 684 COSMIC
COSN22823182 812 COSMIC
COSN9544118 885 COSMIC
COSN31541936 929 COSMIC
COSN26806486 988 COSMIC
COSN31513738 1024 COSMIC
COSN19657938 1030 COSMIC
COSN31565283 1215 COSMIC
COSN19260614 1412 COSMIC
COSN15074003 1470 COSMIC
COSN30174354 1652 COSMIC
COSN26650286 1783 COSMIC
COSN31530048 1810 COSMIC
COSN24230926 1875 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750062124 1 dbSNP
rs761161509 1 dbSNP
rs765005938 1 dbSNP
rs774359585 2 dbSNP
rs1391419042 3 dbSNP
rs574701896 6 dbSNP
rs767728550 9 dbSNP
rs1347741554 10 dbSNP
rs1363869759 13 dbSNP
rs1301711581 15 dbSNP
rs200915849 18 dbSNP
rs761633377 19 dbSNP
rs765007593 21 dbSNP
rs563657200 25 dbSNP
rs758351272 26 dbSNP
rs1365545712 29 dbSNP
rs1296413120 41 dbSNP
rs191880040 43 dbSNP
rs530928397 44 dbSNP
rs138556636 48 dbSNP
rs368767930 48 dbSNP
rs1246680532 51 dbSNP
rs751076329 52 dbSNP
rs545915273 55 dbSNP
rs1170322376 62 dbSNP
rs1415603546 64 dbSNP
rs902063894 82 dbSNP
rs1029762480 87 dbSNP
rs955415341 88 dbSNP
rs977273632 90 dbSNP
rs1258390539 92 dbSNP
rs1182455620 93 dbSNP
rs1485639697 94 dbSNP
rs769995400 96 dbSNP
rs1280233448 99 dbSNP
rs1207819548 103 dbSNP
rs1352704785 103 dbSNP
rs1250461204 108 dbSNP
rs924494359 111 dbSNP
rs564514494 118 dbSNP
rs1006402675 119 dbSNP
rs1237923175 123 dbSNP
rs1016319521 124 dbSNP
rs1285018891 128 dbSNP
rs1369746269 129 dbSNP
rs959463612 136 dbSNP
rs1460664248 142 dbSNP
rs1370359894 143 dbSNP
rs1267089860 151 dbSNP
rs1474917809 159 dbSNP
rs1012225738 165 dbSNP
rs1275989898 167 dbSNP
rs1194368683 175 dbSNP
rs957422049 183 dbSNP
rs111392228 191 dbSNP
rs915772805 220 dbSNP
rs528713289 222 dbSNP
rs1332010423 237 dbSNP
rs981381338 238 dbSNP
rs41276509 239 dbSNP
rs1045342869 240 dbSNP
rs989942605 244 dbSNP
rs1388284470 248 dbSNP
rs928405380 255 dbSNP
rs914298208 257 dbSNP
rs1471423221 266 dbSNP
rs929080934 269 dbSNP
rs943135138 271 dbSNP
rs1177365769 275 dbSNP
rs1473205286 277 dbSNP
rs140972380 279 dbSNP
rs887317759 285 dbSNP
rs941522964 306 dbSNP
rs1038620409 315 dbSNP
rs1453657505 316 dbSNP
rs933020490 317 dbSNP
rs1212710964 321 dbSNP
rs900050285 331 dbSNP
rs1466831629 332 dbSNP
rs1269484103 333 dbSNP
rs1047942745 335 dbSNP
rs886693326 346 dbSNP
rs752468701 350 dbSNP
rs1329588870 366 dbSNP
rs1331450894 374 dbSNP
rs942154016 378 dbSNP
rs1440479910 385 dbSNP
rs550618127 392 dbSNP
rs1392467264 394 dbSNP
rs1444463366 395 dbSNP
rs1322656857 396 dbSNP
rs1401343704 397 dbSNP
rs1029646578 400 dbSNP
rs1157320263 402 dbSNP
rs4858770 407 dbSNP
rs1378610066 412 dbSNP
rs1371652130 418 dbSNP
rs1193323217 419 dbSNP
rs1452202967 438 dbSNP
rs1249493100 441 dbSNP
rs895346963 443 dbSNP
rs547877526 445 dbSNP
rs777768090 446 dbSNP
rs1032167711 449 dbSNP
rs906528797 452 dbSNP
rs1231725258 462 dbSNP
rs957228652 486 dbSNP
rs144654473 492 dbSNP
rs1431640148 503 dbSNP
rs1456110384 505 dbSNP
rs537162431 513 dbSNP
rs1197297097 515 dbSNP
rs1238031830 516 dbSNP
rs1416664543 516 dbSNP
rs1022893935 518 dbSNP
rs1376533720 529 dbSNP
rs551842867 533 dbSNP
rs757180740 534 dbSNP
rs1173469322 544 dbSNP
rs999941100 553 dbSNP
rs1188777885 559 dbSNP
rs1031545552 567 dbSNP
rs981306377 570 dbSNP
rs1239891926 574 dbSNP
rs928331595 577 dbSNP
rs1442943697 592 dbSNP
rs928967357 600 dbSNP
rs570450290 628 dbSNP
rs1208543695 641 dbSNP
rs1344014893 650 dbSNP
rs955972686 661 dbSNP
rs779027526 665 dbSNP
rs908917433 669 dbSNP
rs1477810729 676 dbSNP
rs1450281945 680 dbSNP
rs1356733412 685 dbSNP
rs941547097 691 dbSNP
rs1168773312 693 dbSNP
rs989911324 694 dbSNP
rs539478945 696 dbSNP
rs1038917923 701 dbSNP
rs1433302688 712 dbSNP
rs1021400484 718 dbSNP
rs1398724012 722 dbSNP
rs1171514685 733 dbSNP
rs900105178 734 dbSNP
rs1416873480 741 dbSNP
rs932915186 754 dbSNP
rs1051336775 757 dbSNP
rs1475245090 759 dbSNP
rs745967071 760 dbSNP
rs1443048186 773 dbSNP
rs184263350 774 dbSNP
rs964535943 777 dbSNP
rs1330347835 785 dbSNP
rs1227683992 786 dbSNP
rs891168657 792 dbSNP
rs766616087 794 dbSNP
rs1031762990 799 dbSNP
rs1271143129 801 dbSNP
rs893179751 818 dbSNP
rs17006672 829 dbSNP
rs1217424272 838 dbSNP
rs1023243474 844 dbSNP
rs1292696178 848 dbSNP
rs1377397389 858 dbSNP
rs1273292100 859 dbSNP
rs969851563 864 dbSNP
rs932963615 868 dbSNP
rs1441912024 877 dbSNP
rs1325075503 885 dbSNP
rs187406655 885 dbSNP
rs1461596063 886 dbSNP
rs1035569609 888 dbSNP
rs1265692279 892 dbSNP
rs1162095265 895 dbSNP
rs1473542120 896 dbSNP
rs1408609058 897 dbSNP
rs1176475066 904 dbSNP
rs1479518878 908 dbSNP
rs942247306 913 dbSNP
rs1194354449 915 dbSNP
rs1425984584 917 dbSNP
rs1272629816 928 dbSNP
rs574661034 929 dbSNP
rs895315633 930 dbSNP
rs375669279 931 dbSNP
rs1371599381 935 dbSNP
rs983489660 940 dbSNP
rs1459357080 942 dbSNP
rs535693449 956 dbSNP
rs747290840 958 dbSNP
rs1295615281 961 dbSNP
rs1441187931 965 dbSNP
rs974501824 966 dbSNP
rs557415717 971 dbSNP
rs1323377205 977 dbSNP
rs1389741064 993 dbSNP
rs1382508536 1019 dbSNP
rs1320059136 1025 dbSNP
rs10510499 1034 dbSNP
rs1051347830 1035 dbSNP
rs912783115 1042 dbSNP
rs1293346924 1049 dbSNP
rs934690326 1052 dbSNP
rs1053505015 1067 dbSNP
rs546281211 1069 dbSNP
rs1252592648 1071 dbSNP
rs1247622676 1079 dbSNP
rs1486871064 1080 dbSNP
rs1261875199 1089 dbSNP
rs1215748161 1092 dbSNP
rs1264136048 1097 dbSNP
rs1315585406 1102 dbSNP
rs1303881986 1129 dbSNP
rs1235464925 1131 dbSNP
rs893116707 1138 dbSNP
rs147870914 1150 dbSNP
rs1044450040 1153 dbSNP
rs3749184 1164 dbSNP
rs1265839035 1166 dbSNP
rs1002622599 1169 dbSNP
rs540503641 1178 dbSNP
rs1451546683 1193 dbSNP
rs562092036 1194 dbSNP
rs748670741 1195 dbSNP
rs529438348 1204 dbSNP
rs1030058760 1205 dbSNP
rs3749185 1207 dbSNP
rs1191958581 1225 dbSNP
rs1430471198 1232 dbSNP
rs1262524390 1233 dbSNP
rs1185946047 1236 dbSNP
rs770229343 1236 dbSNP
rs963065872 1249 dbSNP
rs1485212041 1253 dbSNP
rs974934204 1254 dbSNP
rs1283083694 1259 dbSNP
rs1193273006 1263 dbSNP
rs983250437 1266 dbSNP
rs907521538 1267 dbSNP
rs921639857 1278 dbSNP
rs954199471 1286 dbSNP
rs1307647765 1295 dbSNP
rs536144728 1296 dbSNP
rs563102153 1298 dbSNP
rs934930035 1299 dbSNP
rs193162300 1320 dbSNP
rs916844070 1321 dbSNP
rs552268217 1322 dbSNP
rs1454267484 1324 dbSNP
rs570448797 1325 dbSNP
rs534628169 1335 dbSNP
rs1160194014 1343 dbSNP
rs1463734923 1345 dbSNP
rs948204854 1348 dbSNP
rs1169914855 1349 dbSNP
rs1358442614 1352 dbSNP
rs1047017222 1353 dbSNP
rs1260295165 1358 dbSNP
rs1398997308 1368 dbSNP
rs1053360127 1375 dbSNP
rs1255850282 1378 dbSNP
rs68050031 1379 dbSNP
rs947406134 1386 dbSNP
rs1044463600 1392 dbSNP
rs1250405558 1395 dbSNP
rs1224660867 1407 dbSNP
rs1336269333 1409 dbSNP
rs1293314539 1410 dbSNP
rs199548798 1413 dbSNP
rs935398694 1414 dbSNP
rs1309686612 1418 dbSNP
rs905923812 1435 dbSNP
rs1052494838 1447 dbSNP
rs1002676443 1455 dbSNP
rs1397534310 1458 dbSNP
rs568403092 1462 dbSNP
rs1311423059 1467 dbSNP
rs1420156771 1469 dbSNP
rs1165665163 1472 dbSNP
rs1475174016 1473 dbSNP
rs1416309970 1484 dbSNP
rs1340356564 1486 dbSNP
rs1438716759 1487 dbSNP
rs1240434600 1488 dbSNP
rs1193738200 1495 dbSNP
rs1469499403 1501 dbSNP
rs1056870408 1503 dbSNP
rs1288568144 1505 dbSNP
rs1273285294 1507 dbSNP
rs893804276 1513 dbSNP
rs75780220 1514 dbSNP
rs1332673103 1515 dbSNP
rs1281181315 1521 dbSNP
rs868253929 1524 dbSNP
rs1239569110 1544 dbSNP
rs767218896 1546 dbSNP
rs556830966 1555 dbSNP
rs1016176597 1565 dbSNP
rs1396887244 1581 dbSNP
rs1281219869 1582 dbSNP
rs1484366407 1587 dbSNP
rs963416771 1594 dbSNP
rs995820780 1595 dbSNP
rs900436876 1611 dbSNP
rs995995861 1621 dbSNP
rs1470770174 1626 dbSNP
rs1030567237 1629 dbSNP
rs775264860 1633 dbSNP
rs1028757643 1634 dbSNP
rs954592902 1648 dbSNP
rs1004634374 1655 dbSNP
rs954419581 1656 dbSNP
rs1285694130 1660 dbSNP
rs987199968 1666 dbSNP
rs1378247634 1680 dbSNP
rs963007745 1681 dbSNP
rs973066239 1689 dbSNP
rs200290890 1694 dbSNP
rs1373546318 1706 dbSNP
rs1304395035 1709 dbSNP
rs1440320693 1715 dbSNP
rs753284594 1721 dbSNP
rs1329439480 1722 dbSNP
rs1320323055 1724 dbSNP
rs1401798875 1725 dbSNP
rs539513458 1726 dbSNP
rs970055967 1728 dbSNP
rs982411966 1730 dbSNP
rs1436937226 1734 dbSNP
rs1046039 1735 dbSNP
rs1062974 1738 dbSNP
rs1464261725 1739 dbSNP
rs956224842 1741 dbSNP
rs1301723707 1747 dbSNP
rs569394376 1748 dbSNP
rs1446413618 1751 dbSNP
rs989506211 1752 dbSNP
rs1212799924 1754 dbSNP
rs1348293979 1777 dbSNP
rs914790725 1778 dbSNP
rs1279280208 1781 dbSNP
rs1233883817 1789 dbSNP
rs1343052114 1794 dbSNP
rs1272012457 1814 dbSNP
rs1431567505 1820 dbSNP
rs947383515 1831 dbSNP
rs928102863 1835 dbSNP
rs980044274 1841 dbSNP
rs558265729 1846 dbSNP
rs1417110787 1862 dbSNP
rs1376480051 1863 dbSNP
rs935551582 1874 dbSNP
rs185372937 1880 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.811 3.8e-4 0.692 4.4e-3 13 Click to see details
GSE28544 Breast cancer 0.583 1.4e-3 0.449 1.4e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.587 1.6e-3 0.571 2.2e-3 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.245 1.2e-1 0.190 1.8e-1 25 Click to see details
GSE19783 ER- ER- breast cancer 0.129 1.3e-1 0.135 1.2e-1 79 Click to see details
GSE19536 Breast cancer 0.105 1.5e-1 0.112 1.3e-1 100 Click to see details
GSE19783 ER+ ER+ breast cancer -0.215 1.8e-1 -0.128 3.0e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.158 2.3e-1 -0.032 4.4e-1 24 Click to see details
GSE17498 Multiple myeloma -0.11 2.5e-1 -0.071 3.3e-1 40 Click to see details
GSE19350 CNS germ cell tumors 0.214 2.5e-1 0.434 7.9e-2 12 Click to see details
GSE21687 Ependynoma primary tumors 0.041 3.7e-1 -0.103 2.1e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.048 4.2e-1 -0.411 3.6e-2 20 Click to see details
GSE38226 Liver fibrosis -0.026 4.6e-1 -0.108 3.2e-1 21 Click to see details
GSE32688 Pancreatic cancer 0 5.0e-1 -0.108 2.8e-1 32 Click to see details
GSE32688 Pancreatic cancer 0 5.0e-1 -0.108 2.8e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.207 0.05 -0.162 0.09 68 Click to see details
CESC -0.985 0.06 -1.000 0.5 3 Click to see details
LUSC -0.259 0.06 -0.243 0.07 38 Click to see details
HNSC 0.242 0.06 0.246 0.06 42 Click to see details
KICH -0.262 0.1 -0.205 0.16 25 Click to see details
THCA -0.161 0.11 -0.128 0.17 59 Click to see details
LIHC -0.173 0.12 -0.189 0.1 49 Click to see details
BRCA -0.107 0.17 -0.063 0.28 84 Click to see details
COAD -0.343 0.2 -0.381 0.18 8 Click to see details
UCEC 0.175 0.24 0.186 0.22 19 Click to see details
STAD -0.128 0.24 -0.213 0.12 32 Click to see details
CHOL -0.268 0.24 -0.183 0.32 9 Click to see details
LUAD -0.193 0.27 0.056 0.43 12 Click to see details
PAAD 0.411 0.29 0.400 0.3 4 Click to see details
PCPG -0.571 0.31 -0.500 0.33 3 Click to see details
BLCA 0.074 0.39 0.183 0.23 18 Click to see details
KIRP -0.022 0.45 0.033 0.43 32 Click to see details
ESCA -0.029 0.47 -0.082 0.41 11 Click to see details
PRAD -0.011 0.47 0.022 0.44 50 Click to see details
PRAD -0.011 0.47 0.022 0.44 50 Click to see details
PRAD -0.011 0.47 0.022 0.44 50 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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