miRTarBase - #MIRT440441


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pre-miRNA Information
pre-miRNA hsa-mir-412   
Genomic Coordinates chr14: 101065447 - 101065537
Synonyms MIRN412, hsa-mir-412, MIR412
Description Homo sapiens miR-412 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-412-3p
Sequence 54| ACUUCACCUGGUCCACUAGCCGU |76
Evidence Not_experimental
Experiments
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
rs61992671 18 GWAS
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369997462 1 dbSNP
rs1439693090 7 dbSNP
rs1301668924 11 dbSNP
rs534204576 13 dbSNP
rs775386036 14 dbSNP
rs762832140 15 dbSNP
rs1203323285 16 dbSNP
rs61992671 18 dbSNP
rs1022012324 19 dbSNP
rs1207609936 20 dbSNP
rs139967426 21 dbSNP
rs539487075 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol INTS3   
Synonyms C1orf193, C1orf60, INT3, SOSS-A, SOSSA
Description integrator complex subunit 3
Transcript NM_023015   
Expression
Putative miRNA Targets on INTS3
3'UTR of INTS3
(miRNA target sites are highlighted)		 
>INTS3|NM_023015|3'UTR
   1 GGCCCTGCATTCCCCATCCCACCCCCGGCTGGACTGCCCTCTCCTTCTTGGTGATTCAAAGGTTAATAGAGGCTGAGGAG
  81 ATTGCAGGGGAAACACCCTTGCTGCATCCCCAAGCTCCCCCGGTGGAAGGAGGAGCTTTCTCCTCTGGCTGAGTTTGAGA
 161 AGCTGCCATGCAGCCCCTAGCCCCTTCCCTCCTCCTGGGGCCTCCAGCCCCTCACACTGCTGTTCCCAGTGATATTTGGG
 241 ATCTGACTGAAGCCAGAGGCTCTGTAAAATCAGACCATAGTGGAAGTCCTCAGCCCCCTGGCCCCTTCCGCAATCTCCTC
 321 CCCCAGTCTCCCAAAGAGCCATTTCAACAGAGAAGGGAAATGACAAAGGGGCAGCTGGCCAGATAAGCTAGGATGAGAGC
 401 AGAGACTCAGTGTGTGGGTGTCCCTTCCTGCTTCCCCTTCAGGTCTTGGTTTGTTCTGAAGGGACGTTTTATAGTCACTA
 481 TCCACATGCCAGTGTGAAATGGGCATCTATGACGTGGTCAGGGTGTCCATTCCTAATCATGGGGCAGATGCCACAAGCAT
 561 TCAGAAAGGAGTCTGAAAGGGTGGCCACAGCCCCACGTGGTGTGCCCTGGAGGCTTAGGTTGGTCTGAGGTTGGCACCTC
 641 AATCTACACCAGAGCCCAGGGAGTCCCAGAGGCAAGTTTCACAGAATTGTCAAATGATCCCATTTCCTTGAGTCTGTTTT
 721 TTTTTTTGTTTTTTTTTGTTTTTTTTTTGGCAGAGATAATCGTGTCTTAAAAGTTGTTTTTAAATGACAATAAAACAAGC
 801 CAGAATGTCTTTTGTGCTGGAGTGTCTGCTGGCATTTGCCCCGTGCATGTATAGCTTGGTCTTGATTTGATTGGCACCCC
 881 TACTTGTAACCGCAGAACATCCCCCTTTCCCTTCCTGTTCTGCCCCCACTTTTGTCTAGAGCAGAAGGGACTTGGCTTTG
 961 GCCACTACCCATCCTTCCTGCTGCCACTGGAGGTGGGAGCCAGGCACTGATCTGTCTATGCAGAACCATCCCCCGTAGGA
1041 TGAGGCCTGTCCTTACTCATTTCTCAAGAAACAAGATGCTTCCAAAAGGTCTGTCATCCTCCAGTTGAAGTCTGTGTGCC
1121 TACCAAGAATGGCCGGAGGACTCGCTGCTTGACGGGAGGGATGCTCCAGCTTGGTCTCCAGGGACAACTGTACCTGGAGA
1201 TAAAGTCTGGATACCAGGGAGGGACAGAGATGCTCTTCCTTCCACAGTGTGGCCACTTGCTGGGCCATGTGAACCAGCAG
1281 AGGAGAGTTCCTTGGCTATGCTGTTGTTCCCCCGCTGTCCAGGGAGAATGGAGGTGGACTGAGGAGTGAAGTTTGGGCGA
1361 ACTGCACAGAGCTGCTCCTCTTCACCCCGAAAATTTGTCTTTTTACAGAATCCAGGTTCTCCCCTCCCTCATCACTGCTG
1441 TTGCTTCCTTTGAAAGTCTAAACCACTGGAGGCTTCTTTTTCCTTCCTCTCTCCTTCCCCAGTTTCCTCTGTCCCAATTA
1521 AAACCAGGATGGAGAGCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugccgaUCACCUGG--UC-CACUUCa 5'
                :||||||:  :| |||||| 
Target 5' aatggaGGTGGACTGAGGAGTGAAGt 3'
 1327 - 1352 131.00 -24.10
2 
miRNA  3' ugccGAUCACCUGGUCCACUUca 5'
              :|: |||:||| |||||  
Target 5' ccacTTGCTGGGCCATGTGAAcc 3'
 1253 - 1275 123.00 -15.90
3 
miRNA  3' ugccgaucaccuGGUCCACUUCa 5'
                      |||| ||||| 
Target 5' gtctgtcatcctCCAGTTGAAGt 3'
 1089 - 1111 123.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30179614 13 COSMIC
COSN30190623 24 COSMIC
COSN30484293 26 COSMIC
COSN20074154 32 COSMIC
COSN30464705 46 COSMIC
COSN30102605 64 COSMIC
COSN30471543 98 COSMIC
COSN30471580 99 COSMIC
COSN23592243 126 COSMIC
COSN30174468 205 COSMIC
COSN23012502 299 COSMIC
COSN30174440 346 COSMIC
COSN20905015 353 COSMIC
COSN30126328 388 COSMIC
COSN30165158 389 COSMIC
COSN30138715 395 COSMIC
COSN15624583 403 COSMIC
COSN32065700 481 COSMIC
COSN30163369 493 COSMIC
COSN31532453 545 COSMIC
COSN31541471 597 COSMIC
COSN28822046 700 COSMIC
COSN26685767 704 COSMIC
COSN31556571 725 COSMIC
COSN30132638 727 COSMIC
COSN31545365 728 COSMIC
COSN23013913 729 COSMIC
COSN24417172 739 COSMIC
COSN29573656 818 COSMIC
COSN8336440 838 COSMIC
COSN1089670 1044 COSMIC
COSN8643186 1388 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs754138766 8 dbSNP
rs1343746269 10 dbSNP
rs369791816 13 dbSNP
rs779186348 15 dbSNP
rs746147769 19 dbSNP
rs1213241310 22 dbSNP
rs1052080983 25 dbSNP
rs758475139 26 dbSNP
rs549302171 27 dbSNP
rs769816352 28 dbSNP
rs1244569178 30 dbSNP
rs1449549341 38 dbSNP
rs773295613 42 dbSNP
rs369691929 44 dbSNP
rs766234972 44 dbSNP
rs1001655729 47 dbSNP
rs770697541 48 dbSNP
rs1364270087 59 dbSNP
rs763258829 62 dbSNP
rs1017092133 81 dbSNP
rs909598489 82 dbSNP
rs1345010565 83 dbSNP
rs146907401 89 dbSNP
rs1157162148 97 dbSNP
rs942417538 99 dbSNP
rs1260507496 105 dbSNP
rs535128236 114 dbSNP
rs41265193 122 dbSNP
rs772538833 123 dbSNP
rs565599258 139 dbSNP
rs1025570622 143 dbSNP
rs1266723782 145 dbSNP
rs1201556212 154 dbSNP
rs955564539 167 dbSNP
rs1267460763 172 dbSNP
rs1213208185 174 dbSNP
rs1318361276 193 dbSNP
rs986695302 194 dbSNP
rs1200261059 196 dbSNP
rs1344125706 201 dbSNP
rs1285709199 207 dbSNP
rs375392383 218 dbSNP
rs539524386 221 dbSNP
rs1361678326 237 dbSNP
rs1287553799 245 dbSNP
rs1431493431 248 dbSNP
rs1346025016 254 dbSNP
rs1175741045 263 dbSNP
rs1468269589 265 dbSNP
rs964026393 272 dbSNP
rs979244498 278 dbSNP
rs773275859 281 dbSNP
rs1052336133 290 dbSNP
rs1479735466 293 dbSNP
rs1010702738 295 dbSNP
rs1184579917 299 dbSNP
rs1486617551 305 dbSNP
rs925129533 306 dbSNP
rs1399179900 309 dbSNP
rs557633144 310 dbSNP
rs576219284 311 dbSNP
rs201599454 314 dbSNP
rs1224655935 318 dbSNP
rs917558937 325 dbSNP
rs949076893 327 dbSNP
rs1044778328 334 dbSNP
rs906101208 340 dbSNP
rs768028532 366 dbSNP
rs1035091282 367 dbSNP
rs1299779013 369 dbSNP
rs750866186 371 dbSNP
rs960681501 373 dbSNP
rs1408384699 385 dbSNP
rs183385964 389 dbSNP
rs1466436572 396 dbSNP
rs898687332 404 dbSNP
rs1168014297 407 dbSNP
rs1283400829 409 dbSNP
rs1430046027 409 dbSNP
rs1182579795 410 dbSNP
rs1459751433 413 dbSNP
rs919476791 415 dbSNP
rs994177314 418 dbSNP
rs1026151593 419 dbSNP
rs1250159379 426 dbSNP
rs955522738 431 dbSNP
rs1283192208 437 dbSNP
rs780413082 438 dbSNP
rs1314874669 441 dbSNP
rs1008637029 444 dbSNP
rs910707494 449 dbSNP
rs749518891 453 dbSNP
rs555744749 454 dbSNP
rs1394466952 464 dbSNP
rs574071082 465 dbSNP
rs979360638 466 dbSNP
rs367746284 467 dbSNP
rs1370932215 474 dbSNP
rs541393665 481 dbSNP
rs1442330621 483 dbSNP
rs1386730080 501 dbSNP
rs115975027 514 dbSNP
rs1247877502 514 dbSNP
rs987851359 515 dbSNP
rs892350644 516 dbSNP
rs1220752124 518 dbSNP
rs534463710 520 dbSNP
rs578011475 522 dbSNP
rs779199692 523 dbSNP
rs1421087442 524 dbSNP
rs113772043 533 dbSNP
rs905017909 537 dbSNP
rs980833108 540 dbSNP
rs926333860 544 dbSNP
rs1423931938 545 dbSNP
rs1303624127 549 dbSNP
rs1035039250 552 dbSNP
rs1351530056 567 dbSNP
rs1422546691 567 dbSNP
rs1367256103 569 dbSNP
rs1163465193 570 dbSNP
rs1132598 574 dbSNP
rs149244420 580 dbSNP
rs1278412032 581 dbSNP
rs1373667072 582 dbSNP
rs1473178422 585 dbSNP
rs376816363 586 dbSNP
rs993424746 591 dbSNP
rs1241818531 597 dbSNP
rs1197943475 598 dbSNP
rs1490935547 600 dbSNP
rs1291107665 606 dbSNP
rs1204766468 607 dbSNP
rs1313380442 611 dbSNP
rs753902478 611 dbSNP
rs1026725354 612 dbSNP
rs1247158894 615 dbSNP
rs1292730611 617 dbSNP
rs1262508222 619 dbSNP
rs866844211 620 dbSNP
rs1436551543 622 dbSNP
rs1203978677 624 dbSNP
rs1233481124 625 dbSNP
rs1459281774 626 dbSNP
rs952116653 627 dbSNP
rs1181905044 629 dbSNP
rs1383165883 636 dbSNP
rs1444567306 639 dbSNP
rs1443836126 640 dbSNP
rs1163976264 641 dbSNP
rs1403089525 641 dbSNP
rs1347156756 642 dbSNP
rs1415925206 642 dbSNP
rs1323975329 649 dbSNP
rs748224472 658 dbSNP
rs1038596280 671 dbSNP
rs772220964 673 dbSNP
rs1354550181 674 dbSNP
rs186612175 677 dbSNP
rs898628373 688 dbSNP
rs1428054430 691 dbSNP
rs1017882596 692 dbSNP
rs1481741909 697 dbSNP
rs964842254 703 dbSNP
rs1192934941 709 dbSNP
rs1381579451 711 dbSNP
rs549265214 714 dbSNP
rs1209640099 715 dbSNP
rs1247228066 715 dbSNP
rs1261414344 715 dbSNP
rs1322886105 715 dbSNP
rs1319860513 717 dbSNP
rs1404713513 717 dbSNP
rs1435430986 717 dbSNP
rs71707457 717 dbSNP
rs780188890 717 dbSNP
rs79253325 717 dbSNP
rs191458427 718 dbSNP
rs1286303950 719 dbSNP
rs1471208234 719 dbSNP
rs933737990 723 dbSNP
rs1338045806 724 dbSNP
rs1474613120 724 dbSNP
rs1047260673 725 dbSNP
rs1461042106 725 dbSNP
rs557553038 726 dbSNP
rs1205675204 727 dbSNP
rs1444029816 727 dbSNP
rs1008335036 728 dbSNP
rs369652122 728 dbSNP
rs1359275559 729 dbSNP
rs1449622694 729 dbSNP
rs200086354 729 dbSNP
rs200538501 729 dbSNP
rs577478018 729 dbSNP
rs868804812 730 dbSNP
rs899845451 732 dbSNP
rs1408774348 734 dbSNP
rs1399002909 735 dbSNP
rs1201834203 736 dbSNP
rs1169640078 738 dbSNP
rs1444185514 738 dbSNP
rs1232435857 739 dbSNP
rs1405561047 739 dbSNP
rs199663864 739 dbSNP
rs546943575 740 dbSNP
rs1436008741 741 dbSNP
rs1461918271 750 dbSNP
rs1205632863 758 dbSNP
rs1188057374 760 dbSNP
rs1358233839 762 dbSNP
rs1044023501 763 dbSNP
rs1238935685 769 dbSNP
rs1474402950 779 dbSNP
rs1402221073 781 dbSNP
rs1229724030 782 dbSNP
rs565693379 791 dbSNP
rs1278450008 803 dbSNP
rs375326864 804 dbSNP
rs905132501 805 dbSNP
rs1308976741 809 dbSNP
rs1424392663 810 dbSNP
rs1364153694 815 dbSNP
rs937806394 825 dbSNP
rs1406245064 826 dbSNP
rs1407259536 829 dbSNP
rs1000751182 839 dbSNP
rs1468491172 843 dbSNP
rs543295054 844 dbSNP
rs557248183 859 dbSNP
rs56167936 865 dbSNP
rs1266583363 871 dbSNP
rs183625895 872 dbSNP
rs1321962660 875 dbSNP
rs537282793 876 dbSNP
rs1221606157 878 dbSNP
rs115143181 879 dbSNP
rs887760070 885 dbSNP
rs926264639 889 dbSNP
rs573932679 892 dbSNP
rs941700249 895 dbSNP
rs372020606 899 dbSNP
rs1344857641 900 dbSNP
rs920168152 904 dbSNP
rs1458861566 923 dbSNP
rs1412859612 926 dbSNP
rs1271338936 929 dbSNP
rs534936222 934 dbSNP
rs930253942 935 dbSNP
rs1221805439 936 dbSNP
rs956234128 940 dbSNP
rs865998843 950 dbSNP
rs1262565884 964 dbSNP
rs1324563361 966 dbSNP
rs553056294 968 dbSNP
rs891311833 971 dbSNP
rs1445126188 983 dbSNP
rs775325213 992 dbSNP
rs1213271233 996 dbSNP
rs1465848752 998 dbSNP
rs1268283188 1002 dbSNP
rs1039800170 1007 dbSNP
rs372993635 1009 dbSNP
rs1000866146 1011 dbSNP
rs1192197886 1013 dbSNP
rs1032378847 1018 dbSNP
rs892377212 1024 dbSNP
rs1263866464 1026 dbSNP
rs1478751607 1028 dbSNP
rs1303804355 1034 dbSNP
rs1220210625 1035 dbSNP
rs1132619 1036 dbSNP
rs1427943739 1041 dbSNP
rs1437620450 1043 dbSNP
rs1389464723 1044 dbSNP
rs946346945 1045 dbSNP
rs1469185159 1065 dbSNP
rs751245468 1068 dbSNP
rs979139174 1078 dbSNP
rs144457343 1079 dbSNP
rs1433531658 1080 dbSNP
rs1418595684 1092 dbSNP
rs1173906623 1094 dbSNP
rs774804394 1097 dbSNP
rs1450945228 1098 dbSNP
rs937922489 1099 dbSNP
rs557478939 1100 dbSNP
rs1400555829 1104 dbSNP
rs1202514143 1123 dbSNP
rs1460342890 1125 dbSNP
rs1258255211 1134 dbSNP
rs970601634 1135 dbSNP
rs1211502734 1140 dbSNP
rs1307272075 1141 dbSNP
rs773938964 1145 dbSNP
rs980888858 1148 dbSNP
rs1363058755 1154 dbSNP
rs896304644 1156 dbSNP
rs1366227298 1164 dbSNP
rs1314419880 1166 dbSNP
rs575426784 1167 dbSNP
rs1404500417 1168 dbSNP
rs1033385226 1170 dbSNP
rs1353633400 1176 dbSNP
rs963130322 1186 dbSNP
rs887883869 1190 dbSNP
rs1006594328 1194 dbSNP
rs1346156029 1206 dbSNP
rs1039063472 1208 dbSNP
rs973027680 1209 dbSNP
rs918946345 1211 dbSNP
rs900538887 1215 dbSNP
rs1480595276 1218 dbSNP
rs951693079 1224 dbSNP
rs1278069751 1227 dbSNP
rs1343366276 1235 dbSNP
rs1350189862 1236 dbSNP
rs1244128738 1239 dbSNP
rs1291287101 1239 dbSNP
rs1204388693 1241 dbSNP
rs1313534608 1243 dbSNP
rs1342336494 1243 dbSNP
rs528621205 1248 dbSNP
rs1286410068 1260 dbSNP
rs542772401 1268 dbSNP
rs761313888 1275 dbSNP
rs1305914295 1276 dbSNP
rs983067421 1279 dbSNP
rs1220079422 1280 dbSNP
rs997766968 1283 dbSNP
rs148003480 1296 dbSNP
rs1456128829 1299 dbSNP
rs1369624279 1301 dbSNP
rs189157344 1305 dbSNP
rs944223871 1312 dbSNP
rs1418964864 1322 dbSNP
rs1200362388 1328 dbSNP
rs1250206696 1329 dbSNP
rs1185034818 1330 dbSNP
rs1483577749 1334 dbSNP
rs1040315772 1335 dbSNP
rs1361741353 1343 dbSNP
rs756966482 1344 dbSNP
rs1208214408 1345 dbSNP
rs921342431 1348 dbSNP
rs540953965 1350 dbSNP
rs1238465567 1351 dbSNP
rs55969427 1352 dbSNP
rs369979286 1356 dbSNP
rs1286359447 1361 dbSNP
rs1411651964 1362 dbSNP
rs1053770750 1363 dbSNP
rs755650185 1375 dbSNP
rs1423295226 1378 dbSNP
rs1303142716 1379 dbSNP
rs892490154 1384 dbSNP
rs1009871663 1387 dbSNP
rs141693763 1389 dbSNP
rs1452403035 1390 dbSNP
rs906480373 1403 dbSNP
rs1409201545 1408 dbSNP
rs1161994511 1413 dbSNP
rs926287792 1422 dbSNP
rs781104038 1423 dbSNP
rs1197223407 1424 dbSNP
rs193266267 1427 dbSNP
rs1450380181 1428 dbSNP
rs1268281030 1443 dbSNP
rs1204829946 1445 dbSNP
rs992023220 1446 dbSNP
rs1316859042 1453 dbSNP
rs1002033446 1459 dbSNP
rs917844380 1467 dbSNP
rs1033499714 1473 dbSNP
rs1335425200 1476 dbSNP
rs545587044 1484 dbSNP
rs1332661345 1485 dbSNP
rs1047557422 1487 dbSNP
rs1381367833 1490 dbSNP
rs1385718344 1494 dbSNP
rs1309723061 1500 dbSNP
rs1321985734 1500 dbSNP
rs994564805 1509 dbSNP
rs1406028421 1510 dbSNP
rs1458180199 1510 dbSNP
rs1171383695 1516 dbSNP
rs1355518439 1518 dbSNP
rs1025907716 1519 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
Click to see details
138 hsa-miR-412-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005780 ACVR1C activin A receptor type 1C 1 1
MIRT062013 YOD1 YOD1 deubiquitinase 2 2
MIRT345112 ATXN7L3 ataxin 7 like 3 2 2
MIRT383735 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT396956 CELF1 CUGBP Elav-like family member 1 2 2
MIRT439280 XIAP X-linked inhibitor of apoptosis 1 1
MIRT439313 VAT1 vesicle amine transport 1 1 1
MIRT439375 TUBA1A tubulin alpha 1a 1 1
MIRT439418 TMOD1 tropomodulin 1 1 1
MIRT439503 SURF4 surfeit 4 1 1
MIRT439563 SON SON DNA binding protein 1 1
MIRT439598 SLC3A2 solute carrier family 3 member 2 1 1
MIRT439670 SETD1B SET domain containing 1B 1 1
MIRT439767 RMND5A required for meiotic nuclear division 5 homolog A 1 1
MIRT439922 PPL periplakin 1 1
MIRT439947 PLEKHA6 pleckstrin homology domain containing A6 1 1
MIRT439952 PLCB4 phospholipase C beta 4 1 1
MIRT439961 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT440005 PEG3 paternally expressed 3 1 1
MIRT440061 OSBPL8 oxysterol binding protein like 8 1 1
MIRT440166 MYH14 myosin heavy chain 14 1 1
MIRT440276 MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 1 1
MIRT440437 IPO13 importin 13 1 1
MIRT440441 INTS3 integrator complex subunit 3 1 1
MIRT440448 INS insulin 1 1
MIRT440461 IGF2R insulin like growth factor 2 receptor 1 1
MIRT440472 IARS isoleucyl-tRNA synthetase 1 1
MIRT440530 GUCY1A3 guanylate cyclase 1 soluble subunit alpha 1 1
MIRT440542 GOLGA2 golgin A2 1 1
MIRT440569 GIGYF1 GRB10 interacting GYF protein 1 1 1
MIRT440608 FTSJD2 cap methyltransferase 1 1 1
MIRT440750 EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1 1
MIRT440781 DOT1L DOT1 like histone lysine methyltransferase 1 1
MIRT440804 DNAJA4 DnaJ heat shock protein family (Hsp40) member A4 1 1
MIRT440867 CSDE1 cold shock domain containing E1 1 1
MIRT440890 CPEB4 cytoplasmic polyadenylation element binding protein 4 1 1
MIRT440917 COL1A1 collagen type I alpha 1 chain 1 1
MIRT440967 CDH22 cadherin 22 1 1
MIRT440968 CDH2 cadherin 2 1 1
MIRT441024 CALR calreticulin 1 1
MIRT441278 ACTB actin beta 1 1
MIRT448421 TNFAIP3 TNF alpha induced protein 3 2 2
MIRT462833 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT465062 TSR1 TSR1, ribosome maturation factor 2 2
MIRT476050 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT485318 MZT1 mitotic spindle organizing protein 1 2 4
MIRT493584 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 6
MIRT494567 BAK1 BCL2 antagonist/killer 1 2 2
MIRT497393 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT503250 ZNF257 zinc finger protein 257 2 10
MIRT503656 ZNF138 zinc finger protein 138 2 10
MIRT505882 RNF219 ring finger protein 219 2 2
MIRT507525 DSTN destrin, actin depolymerizing factor 2 4
MIRT510663 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT514682 ZNF701 zinc finger protein 701 2 4
MIRT515370 ZNF208 zinc finger protein 208 2 6
MIRT525237 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT527963 MTAP methylthioadenosine phosphorylase 2 2
MIRT528482 STAMBPL1 STAM binding protein like 1 2 2
MIRT529909 C1orf64 steroid receptor associated and regulated protein 2 4
MIRT531558 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT532234 KLF2 Kruppel like factor 2 2 4
MIRT532480 HOXA13 homeobox A13 2 2
MIRT535544 P2RY2 purinergic receptor P2Y2 2 2
MIRT547311 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT551795 ZNF117 zinc finger protein 117 2 4
MIRT554939 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT558171 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT568771 LY6K lymphocyte antigen 6 family member K 2 2
MIRT570766 ZNF99 zinc finger protein 99 2 2
MIRT572405 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT573396 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610403 RXRB retinoid X receptor beta 2 2
MIRT610886 SCN8A sodium voltage-gated channel alpha subunit 8 2 2
MIRT611197 TMEM105 transmembrane protein 105 2 2
MIRT611244 ZNF550 zinc finger protein 550 2 2
MIRT615669 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 4
MIRT617974 DOCK4 dedicator of cytokinesis 4 2 2
MIRT619150 ZNF326 zinc finger protein 326 2 2
MIRT619608 MKKS McKusick-Kaufman syndrome 2 2
MIRT621053 DGKD diacylglycerol kinase delta 2 2
MIRT623665 HRK harakiri, BCL2 interacting protein 2 2
MIRT624883 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT624939 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT634198 TMOD2 tropomodulin 2 2 4
MIRT636727 AGO2 argonaute 2, RISC catalytic component 2 2
MIRT637741 POLR3K RNA polymerase III subunit K 2 2
MIRT638002 ZC3H13 zinc finger CCCH-type containing 13 2 2
MIRT640395 ZNF785 zinc finger protein 785 2 2
MIRT640505 ANTXR1 anthrax toxin receptor 1 2 2
MIRT641293 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT641863 STOML1 stomatin like 1 2 2
MIRT642600 C14orf180 chromosome 14 open reading frame 180 2 2
MIRT642895 CASP1 caspase 1 2 2
MIRT643967 FHL2 four and a half LIM domains 2 2 4
MIRT645237 KCTD12 potassium channel tetramerization domain containing 12 2 2
MIRT646621 CENPL centromere protein L 2 2
MIRT648620 CYB561A3 cytochrome b561 family member A3 2 2
MIRT648908 ZNF551 zinc finger protein 551 2 2
MIRT649439 HIBADH 3-hydroxyisobutyrate dehydrogenase 2 2
MIRT650637 LTF lactotransferrin 2 2
MIRT650971 STARD3NL STARD3 N-terminal like 2 2
MIRT651067 ZNF518B zinc finger protein 518B 2 4
MIRT652384 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT653958 SEPN1 selenoprotein N 2 2
MIRT656885 KIF1C kinesin family member 1C 2 2
MIRT657965 GAPVD1 GTPase activating protein and VPS9 domains 1 2 2
MIRT658080 FOXR2 forkhead box R2 2 2
MIRT662570 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT663089 METTL10 EEF1A lysine methyltransferase 2 2 2
MIRT683705 ZNF195 zinc finger protein 195 2 2
MIRT683835 ZNF682 zinc finger protein 682 2 2
MIRT706811 APOL4 apolipoprotein L4 2 2
MIRT707575 DYNC2LI1 dynein cytoplasmic 2 light intermediate chain 1 2 2
MIRT708606 ZNF260 zinc finger protein 260 2 2
MIRT708859 TMSB4X thymosin beta 4, X-linked 2 2
MIRT709861 PDIK1L PDLIM1 interacting kinase 1 like 2 2
MIRT709987 RBM41 RNA binding motif protein 41 2 2
MIRT710098 KPNA5 karyopherin subunit alpha 5 2 2
MIRT710211 ENAH ENAH, actin regulator 2 2
MIRT710868 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT710986 SUSD5 sushi domain containing 5 2 2
MIRT711460 RNF145 ring finger protein 145 2 2
MIRT712302 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT713609 SYTL4 synaptotagmin like 4 2 2
MIRT713789 MAK16 MAK16 homolog 2 2
MIRT715480 MYO9B myosin IXB 2 2
MIRT716328 POU5F1 POU class 5 homeobox 1 2 2
MIRT717252 TMEM246 transmembrane protein 246 2 2
MIRT718077 CLIC5 chloride intracellular channel 5 2 2
MIRT718463 EED embryonic ectoderm development 2 2
MIRT718645 NKPD1 NTPase KAP family P-loop domain containing 1 2 2
MIRT718982 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT721078 RPS9 ribosomal protein S9 2 2
MIRT721419 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT721863 CENPJ centromere protein J 2 2
MIRT722492 PNKD paroxysmal nonkinesigenic dyskinesia 2 2
MIRT723391 CALN1 calneuron 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-412 Gemcitabine approved 60750 Northern blot Mz-ChA-1 human cholangiocarcinoma cell lines 16762633 2006 down-regulated
miR-412 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-412 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-412 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-412-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-412-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (A2780)
hsa-miR-412-3p Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-412-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-412-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-412-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-412-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-412-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-412-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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