pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FBXL16   
Synonyms C16orf22, Fbl16, c380A1.1
Description F-box and leucine rich repeat protein 16
Transcript NM_153350   
Expression
Putative miRNA Targets on FBXL16
3'UTR of FBXL16
(miRNA target sites are highlighted)
>FBXL16|NM_153350|3'UTR
   1 CGCGAGGCCCCCGCCCCGGTCGCGGGAACCCGGCCATGACCTGGGCGGGGGCGCGGGGCGCCGCCGAGCCCCCTCTTCCC
  81 GCCTTGCGCTCGGGGGAGCCCCCGCGCCCCCGGCCCAGCGCGGGAGGCGGGGCGAGCCGAGGGAAAGCCCCTCCCCGACC
 161 TTCGGTCCCTCCGCCCTCCCAGCCCCGCCCCGGGCAGGGGGGCGGCGGGTGGGCCCGCCCCACGCACGCACGCACACTCG
 241 GGGACTTTGTGCATGCCCCTCGTGCCCGCACTGCACGCCGCCCTCCGCCACGCCACAGCCACAGCCGCCGCCATCACTCG
 321 CTCGCCCTCCCGCTTGGGGGGCGGGGCTCGGTCCTTGGGGGGGCTTTGAGCTCTCCAGACTGTGCCCTTACCGCCTTCCC
 401 CGCCACACCCGCTCTGTCTTCCCACTGTCCCCCCCATCCCGGGCAGGGCCCAGTGGGATTGAGGGGGCTGGGTCCCCCAG
 481 GACACGGGCCCAGAAGAGCCCCACGGGCTTCCTGCATCTTCCACCGCACCATACCTGGAGCCCTCCGAGGGGTGTCAGGG
 561 GAAACAGGCCACCGCCAAAGCCATGGCCCGCCGCCGAGAGCCCAGGCCCCACCCGCACCTCCTCACCCATCCAGCCTGAC
 641 CCACGCGGCCTCTCCTCCTCCTTGCCGCTGTGTGGGGCAGTCCCCTGTCCGCCCCAAAACCCGGCCTTGGTCCCTGGCCA
 721 GGCTGAGAGAATTGGGCAGGGAGAGGGCGGAAGGGCTGGCGATCGCTTGGAGTCATTAACGTGATCCCAGCTGACTCCGG
 801 TCGGCCTCAACCCAGGGGTGGCGCAGGCACCTTGCAAGCCTCGAGCTGTAGCCACCCTCAGGCCTGGGAAGAGGCCTGGG
 881 CCGACCTCACACCTCAGCCCTTGCACCCGGCCGGGCTCAGTTCAGGCCTGGGCACCGAGCTTCACCCTGGGTGGGTCTCC
 961 TCAGGTGGAGTCTGCAGAGTGGACCCAGCCAAGGGTCAGGGTCAGCACTGGGTCAGCGACTCCAATCTTCCAGTGGCCAG
1041 CACACCCTAGACACCCCGAGGAGGGAGGGCTCCTTTCTAGCCTGCCCCCCCACCCCCACTTCACCCCTCCCCAGCTTCCC
1121 AAACTTCTGTCTGCCCAAATGGGCTCTGACCGTGCTCTGTCGGCCCGAGACATTTGGAAGTCCTGGGGGATGCTGGCAAA
1201 TCTCAGCTGTTGCTGAGGAGGGGGCTGGGACCCCTTCCCATCCCAACCTTGAGCCCCAGGAGATACCGCGCCCACACCCA
1281 ATCTTGGGACACTCCCTATCTGGTTGGAAGAGAGTAACCAGTTTCCAGAGAGCCAGAGAGTGAGAGAGAGAAAGAGAGTG
1361 AGAGAGAGAGAGAAAGAGAGAGAGAGATGCTGTTGAATCAGAAACAGATCAACAGCCCAAAGATTTTCCTGTCCCTGGAG
1441 TGCCAGCCCCAGGAAGCTCCAGGGCTGAGTGGTCAGGAGCCAGTTTCTCCAGCCCCTCCTCCCCACAACCCCTAGTGGGG
1521 AGGGGCAGCTGTCCATTTGCCCAAAGTATTAATGCAACTGAAGCTGTGATATTTCCAACGACTGTAGGAGGAAAAATTAA
1601 GGGGAGAGAGGAAAACAAAACCAACCAACCCCTAAAATCATTTTCTTATTGTACATAACGACCTCATTCTCCTGTATATG
1681 CGGAAGATATAACCTTATATTTGGTAAGTGTTTCTTGTGCTATTTTATCACGTGACCTGTTTATAAAAATATATATTAAA
1761 AAAGTTGTAAAAACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' uaUUCU-CAG-AGGGGGACAUAUa 5'
            | ||  || |:|:|||||||| 
Target 5' taACGACCTCATTCTCCTGTATAt 3'
1656 - 1679 160.00 -16.00
2
miRNA  3' uauucucaGAGGGGGACAUAUa 5'
                  :| || ||||:|: 
Target 5' cctcctccTTGCCGCTGTGTGg 3'
654 - 675 118.00 -13.11
3
miRNA  3' uauucUCAGAGGGGGACAUaua 5'
               || |||   |||||   
Target 5' ttgcaAGCCTCGAGCTGTAgcc 3'
832 - 853 113.00 -7.22
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30147424 4 COSMIC
COSN30150937 4 COSMIC
COSN26551239 21 COSMIC
COSN26976124 25 COSMIC
COSN1190538 30 COSMIC
COSN20120706 46 COSMIC
COSN18715716 133 COSMIC
COSN23266075 219 COSMIC
COSN22219767 256 COSMIC
COSN18747649 292 COSMIC
COSN31531634 356 COSMIC
COSN21616827 421 COSMIC
COSN30174189 461 COSMIC
COSN31482547 574 COSMIC
COSN32150143 596 COSMIC
COSN31589358 658 COSMIC
COSN32056738 680 COSMIC
COSN30175412 725 COSMIC
COSN31533221 744 COSMIC
COSN31540786 828 COSMIC
COSN17037370 1057 COSMIC
COSN17975134 1092 COSMIC
COSN16556675 1292 COSMIC
COSN16288054 1330 COSMIC
COSN20112493 1335 COSMIC
COSN22843538 1360 COSMIC
COSN31579181 1415 COSMIC
COSN31572666 1564 COSMIC
COSN1708440 1570 COSMIC
COSN22045748 1605 COSMIC
COSN31551851 1645 COSMIC
COSN17620440 1758 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs367614744 2 dbSNP
rs766158199 3 dbSNP
rs760469740 6 dbSNP
rs773077964 8 dbSNP
rs771986831 11 dbSNP
rs1349106397 13 dbSNP
rs148739956 15 dbSNP
rs1388691068 16 dbSNP
rs768103665 17 dbSNP
rs748918224 18 dbSNP
rs1429514616 23 dbSNP
rs1407223719 24 dbSNP
rs1039539172 29 dbSNP
rs1006998517 32 dbSNP
rs1190030725 38 dbSNP
rs1472223640 40 dbSNP
rs1480817675 42 dbSNP
rs1271269570 46 dbSNP
rs1421724017 47 dbSNP
rs1163669525 52 dbSNP
rs1394374135 54 dbSNP
rs185623566 55 dbSNP
rs1338408223 64 dbSNP
rs1055312130 66 dbSNP
rs1053798178 68 dbSNP
rs1234875798 69 dbSNP
rs935309222 70 dbSNP
rs1381836812 75 dbSNP
rs1226914897 80 dbSNP
rs1312294544 81 dbSNP
rs928208441 87 dbSNP
rs983442978 88 dbSNP
rs929328656 91 dbSNP
rs1482714174 95 dbSNP
rs1378981862 98 dbSNP
rs1239095061 99 dbSNP
rs1482168270 100 dbSNP
rs1181013722 102 dbSNP
rs1390411293 104 dbSNP
rs1450940955 108 dbSNP
rs1166238491 112 dbSNP
rs1332197223 112 dbSNP
rs923936785 115 dbSNP
rs1046671595 121 dbSNP
rs1394342273 125 dbSNP
rs1174568348 128 dbSNP
rs1466703600 131 dbSNP
rs1401301672 133 dbSNP
rs181135441 139 dbSNP
rs1446284152 142 dbSNP
rs949647855 148 dbSNP
rs1366268000 151 dbSNP
rs916763102 153 dbSNP
rs990918483 155 dbSNP
rs964837042 157 dbSNP
rs1017834035 159 dbSNP
rs12934629 160 dbSNP
rs987325775 161 dbSNP
rs958457058 164 dbSNP
rs1310300761 167 dbSNP
rs1209247255 168 dbSNP
rs1248396884 169 dbSNP
rs954595932 172 dbSNP
rs1186246193 177 dbSNP
rs537335868 180 dbSNP
rs909594931 187 dbSNP
rs1192361182 188 dbSNP
rs1383403490 191 dbSNP
rs1427945911 193 dbSNP
rs574919273 195 dbSNP
rs1483359478 199 dbSNP
rs1389797641 200 dbSNP
rs562180431 203 dbSNP
rs998475266 203 dbSNP
rs904222004 204 dbSNP
rs188252904 206 dbSNP
rs1025719450 207 dbSNP
rs1268572729 208 dbSNP
rs1330988580 209 dbSNP
rs1013053855 210 dbSNP
rs894227384 210 dbSNP
rs1451815012 213 dbSNP
rs1309892178 214 dbSNP
rs1477347388 214 dbSNP
rs976720029 215 dbSNP
rs965265888 216 dbSNP
rs535549618 217 dbSNP
rs568021031 218 dbSNP
rs908676214 221 dbSNP
rs1018135345 222 dbSNP
rs1325669711 222 dbSNP
rs1435799675 228 dbSNP
rs1006697342 231 dbSNP
rs1311500950 233 dbSNP
rs1048029406 236 dbSNP
rs1226418313 236 dbSNP
rs543438240 236 dbSNP
rs1211229267 238 dbSNP
rs879178290 238 dbSNP
rs1205185297 242 dbSNP
rs973445163 243 dbSNP
rs943410895 249 dbSNP
rs1180548338 257 dbSNP
rs1473272902 258 dbSNP
rs1381229889 261 dbSNP
rs1411836086 264 dbSNP
rs1424105368 266 dbSNP
rs1308709914 267 dbSNP
rs1372392459 268 dbSNP
rs893899722 271 dbSNP
rs1307223376 278 dbSNP
rs910647797 280 dbSNP
rs1246647401 281 dbSNP
rs546775157 282 dbSNP
rs534561522 287 dbSNP
rs1228591070 291 dbSNP
rs113541943 295 dbSNP
rs3833954 295 dbSNP
rs1203595018 297 dbSNP
rs1250385341 300 dbSNP
rs1443376559 304 dbSNP
rs1189969251 307 dbSNP
rs954586104 317 dbSNP
rs1031531355 319 dbSNP
rs1256386698 320 dbSNP
rs1000003040 321 dbSNP
rs1208201002 322 dbSNP
rs902534320 325 dbSNP
rs1489166930 327 dbSNP
rs1427854121 329 dbSNP
rs1046803503 330 dbSNP
rs1167279934 336 dbSNP
rs373803558 337 dbSNP
rs1331949748 342 dbSNP
rs1381665726 342 dbSNP
rs1435338866 342 dbSNP
rs895367037 349 dbSNP
rs1339494376 357 dbSNP
rs552533161 358 dbSNP
rs1055221430 359 dbSNP
rs530798048 360 dbSNP
rs942242083 362 dbSNP
rs1250078227 363 dbSNP
rs1003695692 364 dbSNP
rs1035483518 364 dbSNP
rs1192482221 364 dbSNP
rs906726046 365 dbSNP
rs1170648408 368 dbSNP
rs1405045062 373 dbSNP
rs909377082 375 dbSNP
rs1457539667 379 dbSNP
rs1322162996 380 dbSNP
rs1047936962 385 dbSNP
rs1381227085 388 dbSNP
rs993725255 391 dbSNP
rs1332225602 393 dbSNP
rs1342858499 397 dbSNP
rs1291668820 398 dbSNP
rs1402032899 407 dbSNP
rs1323298743 409 dbSNP
rs1270252488 411 dbSNP
rs899418489 411 dbSNP
rs1297949738 415 dbSNP
rs983916141 421 dbSNP
rs1038074706 422 dbSNP
rs929696845 429 dbSNP
rs563688878 430 dbSNP
rs1472803897 431 dbSNP
rs1161025161 432 dbSNP
rs548564355 433 dbSNP
rs578011648 434 dbSNP
rs559639611 435 dbSNP
rs1345354643 436 dbSNP
rs968571580 436 dbSNP
rs1229474214 440 dbSNP
rs1290590195 442 dbSNP
rs965298592 446 dbSNP
rs1457975150 452 dbSNP
rs991560244 455 dbSNP
rs1416474290 459 dbSNP
rs1489520068 459 dbSNP
rs1018166326 464 dbSNP
rs1208078969 471 dbSNP
rs1185376242 474 dbSNP
rs985374018 479 dbSNP
rs541508999 487 dbSNP
rs958422348 491 dbSNP
rs957893559 495 dbSNP
rs1263689516 501 dbSNP
rs1192199271 502 dbSNP
rs1445272673 505 dbSNP
rs1165065225 506 dbSNP
rs1369777280 514 dbSNP
rs1455934499 518 dbSNP
rs1002593834 525 dbSNP
rs1210284946 528 dbSNP
rs1365574280 529 dbSNP
rs1410956882 534 dbSNP
rs951126847 535 dbSNP
rs1371674939 541 dbSNP
rs577402288 542 dbSNP
rs79465812 543 dbSNP
rs370731421 545 dbSNP
rs1220743982 547 dbSNP
rs902566085 550 dbSNP
rs79265881 552 dbSNP
rs1231054067 553 dbSNP
rs1013500624 554 dbSNP
rs1429045339 557 dbSNP
rs1333122894 559 dbSNP
rs761827352 559 dbSNP
rs370797803 560 dbSNP
rs1257915405 561 dbSNP
rs757183494 568 dbSNP
rs1162432220 569 dbSNP
rs1390228353 571 dbSNP
rs1431066718 590 dbSNP
rs895148049 592 dbSNP
rs1171060267 595 dbSNP
rs1324819042 601 dbSNP
rs74002844 605 dbSNP
rs1303788374 607 dbSNP
rs1393161904 608 dbSNP
rs889151518 611 dbSNP
rs1162137687 612 dbSNP
rs1051728550 615 dbSNP
rs933384660 618 dbSNP
rs878901739 630 dbSNP
rs1423884899 632 dbSNP
rs1041523087 635 dbSNP
rs535058967 642 dbSNP
rs1257520038 644 dbSNP
rs947279358 647 dbSNP
rs914456040 649 dbSNP
rs1248211696 650 dbSNP
rs942274748 652 dbSNP
rs1166902462 659 dbSNP
rs991450489 663 dbSNP
rs887975585 665 dbSNP
rs574370939 666 dbSNP
rs1409883132 669 dbSNP
rs1248195498 672 dbSNP
rs1048584995 674 dbSNP
rs1468520344 676 dbSNP
rs763891645 683 dbSNP
rs929755407 685 dbSNP
rs918299155 688 dbSNP
rs976449714 690 dbSNP
rs943727080 691 dbSNP
rs184181574 692 dbSNP
rs985396729 696 dbSNP
rs1303271573 699 dbSNP
rs762746803 701 dbSNP
rs925152954 702 dbSNP
rs534699730 715 dbSNP
rs867056807 726 dbSNP
rs993664544 732 dbSNP
rs554510296 735 dbSNP
rs978293241 737 dbSNP
rs1318940808 746 dbSNP
rs1272568355 748 dbSNP
rs1212985496 749 dbSNP
rs570682162 759 dbSNP
rs749445608 760 dbSNP
rs552366658 761 dbSNP
rs1016918662 763 dbSNP
rs1479662151 764 dbSNP
rs1176148693 775 dbSNP
rs1440878960 781 dbSNP
rs1458995042 782 dbSNP
rs1316367943 786 dbSNP
rs1344720705 787 dbSNP
rs1369427804 788 dbSNP
rs1025518111 790 dbSNP
rs889387141 793 dbSNP
rs537352908 797 dbSNP
rs1013615490 799 dbSNP
rs997504936 801 dbSNP
rs1489727471 803 dbSNP
rs1354545477 804 dbSNP
rs541000445 805 dbSNP
rs1407805377 808 dbSNP
rs193265437 815 dbSNP
rs1006446499 817 dbSNP
rs1271761595 818 dbSNP
rs1489997945 821 dbSNP
rs887998850 825 dbSNP
rs1047900108 827 dbSNP
rs1453790339 830 dbSNP
rs1471340710 837 dbSNP
rs1157072167 840 dbSNP
rs1407460668 841 dbSNP
rs1393179709 846 dbSNP
rs78972403 853 dbSNP
rs1363701305 854 dbSNP
rs1458297322 863 dbSNP
rs1404235832 868 dbSNP
rs931576896 871 dbSNP
rs1352119912 873 dbSNP
rs1056053048 883 dbSNP
rs1278594743 886 dbSNP
rs1356602765 890 dbSNP
rs1229588894 892 dbSNP
rs1288927523 893 dbSNP
rs573698923 908 dbSNP
rs1444312633 909 dbSNP
rs928543697 913 dbSNP
rs1040853338 914 dbSNP
rs1279867860 923 dbSNP
rs981097354 928 dbSNP
rs559686121 935 dbSNP
rs1234007603 939 dbSNP
rs1346104440 946 dbSNP
rs929667738 951 dbSNP
rs1424041508 957 dbSNP
rs1312106774 964 dbSNP
rs547606516 965 dbSNP
rs943758160 968 dbSNP
rs1241452828 969 dbSNP
rs918323074 975 dbSNP
rs973847821 977 dbSNP
rs962792608 979 dbSNP
rs1016411296 981 dbSNP
rs986709217 982 dbSNP
rs953622450 993 dbSNP
rs1439619937 994 dbSNP
rs766598166 1002 dbSNP
rs910906222 1003 dbSNP
rs1313320546 1009 dbSNP
rs1030577938 1015 dbSNP
rs532606819 1017 dbSNP
rs1049392829 1018 dbSNP
rs916152679 1018 dbSNP
rs1342080786 1019 dbSNP
rs565150578 1020 dbSNP
rs562979463 1022 dbSNP
rs1443256385 1024 dbSNP
rs925151984 1025 dbSNP
rs1185679334 1028 dbSNP
rs1241456479 1031 dbSNP
rs1160408796 1037 dbSNP
rs1189291982 1038 dbSNP
rs978030766 1044 dbSNP
rs1419579307 1045 dbSNP
rs1011637773 1052 dbSNP
rs966979591 1053 dbSNP
rs1402679065 1054 dbSNP
rs1470806763 1055 dbSNP
rs893212402 1057 dbSNP
rs1055597789 1058 dbSNP
rs1297081697 1060 dbSNP
rs1328757214 1061 dbSNP
rs1225838186 1063 dbSNP
rs1270087664 1066 dbSNP
rs917744929 1067 dbSNP
rs937207120 1069 dbSNP
rs1261574495 1070 dbSNP
rs1461028547 1077 dbSNP
rs907117481 1085 dbSNP
rs1407403357 1087 dbSNP
rs1263901969 1089 dbSNP
rs543567104 1091 dbSNP
rs1192408234 1092 dbSNP
rs1378078115 1092 dbSNP
rs1481299852 1092 dbSNP
rs1473931907 1094 dbSNP
rs959425310 1095 dbSNP
rs1033655180 1096 dbSNP
rs1428242425 1098 dbSNP
rs1457423313 1100 dbSNP
rs1210359511 1103 dbSNP
rs1290159494 1108 dbSNP
rs1382183909 1109 dbSNP
rs1006145202 1111 dbSNP
rs1484911352 1113 dbSNP
rs1288532895 1114 dbSNP
rs1346691703 1121 dbSNP
rs1218046001 1127 dbSNP
rs952333791 1131 dbSNP
rs1281744853 1133 dbSNP
rs1308806397 1134 dbSNP
rs1305753947 1135 dbSNP
rs576329430 1141 dbSNP
rs544414295 1144 dbSNP
rs190211775 1150 dbSNP
rs1380634122 1151 dbSNP
rs993758874 1152 dbSNP
rs902040766 1162 dbSNP
rs1268059223 1166 dbSNP
rs1040538346 1167 dbSNP
rs1267881538 1167 dbSNP
rs986312487 1174 dbSNP
rs1160870812 1176 dbSNP
rs1353383022 1182 dbSNP
rs1299777498 1185 dbSNP
rs1007991214 1186 dbSNP
rs760705270 1203 dbSNP
rs1030525356 1207 dbSNP
rs1407259214 1215 dbSNP
rs1344522888 1223 dbSNP
rs555439134 1224 dbSNP
rs1392267635 1228 dbSNP
rs1309431115 1230 dbSNP
rs1315349190 1231 dbSNP
rs1238499760 1233 dbSNP
rs1292566411 1234 dbSNP
rs1361555836 1235 dbSNP
rs1220205477 1238 dbSNP
rs1407163043 1241 dbSNP
rs1483261670 1241 dbSNP
rs1418619570 1242 dbSNP
rs1178720753 1246 dbSNP
rs772761210 1259 dbSNP
rs936372545 1267 dbSNP
rs1474333935 1268 dbSNP
rs924963471 1269 dbSNP
rs1265842549 1273 dbSNP
rs1042726349 1274 dbSNP
rs543295696 1277 dbSNP
rs1259498788 1282 dbSNP
rs1462880147 1292 dbSNP
rs1300255847 1294 dbSNP
rs917768926 1297 dbSNP
rs1323022841 1298 dbSNP
rs991925130 1302 dbSNP
rs1273247352 1311 dbSNP
rs1232344266 1312 dbSNP
rs1034887962 1318 dbSNP
rs938105941 1328 dbSNP
rs1315949230 1339 dbSNP
rs1001358685 1341 dbSNP
rs1385116717 1341 dbSNP
rs926671687 1342 dbSNP
rs1307990947 1344 dbSNP
rs1206423333 1352 dbSNP
rs1249371395 1352 dbSNP
rs1480164433 1352 dbSNP
rs984840132 1354 dbSNP
rs1244536487 1355 dbSNP
rs1045603354 1356 dbSNP
rs1360936312 1358 dbSNP
rs952179314 1359 dbSNP
rs1182441647 1367 dbSNP
rs1287081509 1369 dbSNP
rs1429607472 1370 dbSNP
rs754019630 1370 dbSNP
rs762423038 1372 dbSNP
rs1026304102 1374 dbSNP
rs1038008461 1374 dbSNP
rs756133070 1374 dbSNP
rs770711429 1374 dbSNP
rs897079723 1374 dbSNP
rs1408564143 1376 dbSNP
rs1450611656 1376 dbSNP
rs1314436076 1378 dbSNP
rs1438457707 1381 dbSNP
rs1362618611 1382 dbSNP
rs373816327 1382 dbSNP
rs1293293445 1386 dbSNP
rs1306718149 1386 dbSNP
rs1202540486 1388 dbSNP
rs1223823631 1388 dbSNP
rs1242160665 1388 dbSNP
rs756693846 1388 dbSNP
rs910954075 1388 dbSNP
rs941059778 1388 dbSNP
rs1486541205 1390 dbSNP
rs1188827245 1409 dbSNP
rs966289500 1412 dbSNP
rs1417925555 1416 dbSNP
rs1019128791 1426 dbSNP
rs1428299196 1434 dbSNP
rs1177580550 1435 dbSNP
rs1007690710 1444 dbSNP
rs1431778931 1456 dbSNP
rs774930840 1457 dbSNP
rs1468399375 1462 dbSNP
rs889283430 1465 dbSNP
rs1028108833 1468 dbSNP
rs1000607163 1469 dbSNP
rs1049969735 1480 dbSNP
rs1287052017 1489 dbSNP
rs1164259821 1494 dbSNP
rs933753666 1507 dbSNP
rs903540269 1509 dbSNP
rs923416014 1511 dbSNP
rs1284937423 1513 dbSNP
rs537125799 1517 dbSNP
rs945300024 1519 dbSNP
rs1222558349 1522 dbSNP
rs552911994 1524 dbSNP
rs369469797 1534 dbSNP
rs896374990 1535 dbSNP
rs377665061 1539 dbSNP
rs1318216147 1541 dbSNP
rs1212958397 1543 dbSNP
rs1240923745 1557 dbSNP
rs976223807 1560 dbSNP
rs967568877 1569 dbSNP
rs1271530990 1579 dbSNP
rs913507754 1587 dbSNP
rs76076782 1590 dbSNP
rs769174917 1591 dbSNP
rs576972690 1595 dbSNP
rs937887997 1597 dbSNP
rs749615140 1607 dbSNP
rs558789667 1611 dbSNP
rs1405450724 1622 dbSNP
rs1193476379 1626 dbSNP
rs1304835106 1629 dbSNP
rs1469280732 1631 dbSNP
rs1404049548 1632 dbSNP
rs926452399 1640 dbSNP
rs149561458 1642 dbSNP
rs1375069307 1649 dbSNP
rs779623089 1654 dbSNP
rs919262961 1660 dbSNP
rs1024107715 1662 dbSNP
rs1223905558 1663 dbSNP
rs1294514538 1669 dbSNP
rs994010873 1681 dbSNP
rs1198590097 1683 dbSNP
rs1259599402 1684 dbSNP
rs972053295 1687 dbSNP
rs765277395 1707 dbSNP
rs1227653988 1710 dbSNP
rs1379798157 1715 dbSNP
rs1306733069 1727 dbSNP
rs569858523 1731 dbSNP
rs1220910716 1732 dbSNP
rs1165413851 1736 dbSNP
rs1363571086 1738 dbSNP
rs185682837 1743 dbSNP
rs769458019 1746 dbSNP
rs1337200054 1757 dbSNP
rs192324545 1758 dbSNP
rs986372018 1763 dbSNP
rs1005203491 1764 dbSNP
rs1278538673 1764 dbSNP
rs1382903378 1772 dbSNP
rs953554204 1776 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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