miRTarBase - #MIRT440773


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DST   
Synonyms BP240, BPA, BPAG1, CATX-15, CATX15, D6S1101, DMH, DT, EBSB2, HSAN6, MACF2
Description dystonin
Transcript NM_001144769   
Other Transcripts NM_001144770 , NM_001723 , NM_015548 , NM_183380   
Expression
Putative miRNA Targets on DST
3'UTR of DST
(miRNA target sites are highlighted)		 
>DST|NM_001144769|3'UTR
   1 TGCAATTGGTTCTACCAAGGCCCTTCCTTGAGCATTTATTATTTAAGTTTGAACGATGTAAAATATGGTGTAGAAATTCT
  81 TGTGAAATATTGCAAGAGGCGAGTTTAAAATTCTGCAGATGGCCTTATTTGTGTATTTGTCTTTTTATTTTATCTGTATA
 161 ATTTTTTTTGTCAGATATTCTGGGGTTAAAGTCACATCATATGTGAGGAGGAAAAGTTTAACATGAACTAACATTTCTGC
 241 ACTGTAACGTGCCGGGCACACACTAAACTCAGTTACTGTACCTACAGGTAAGTCTACATCCTCTCTGACAGCCACAGCAC
 321 TACATCAATCCCTGACGTTAGGGATACCTCATGACATTTTCCTGTTTTTATGGAAACTCTGAGAAGCTGAATGATACATG
 401 CAGGGGATATTTTTTGAGATGATTTAAATGTAAACCAAAAGATGGAAGACAAAAAGACAAACACACCCACACGCAGTCTT
 481 TGCAGTATCTGACAGAGAACTCACAGGAAGTTACTTCAAGCACTTGCCAGTACTATGATATTCAAGTACCTTGCAGCATT
 561 TCTCTGCCATTGCTTTCAATGAGGCCAGAGGCATCCTGGATATTAGACCTATTATACTGTAAGAATATAAGTATAAAGTG
 641 CGTTCATATACATGTGAGGTTTTCTTTTGCTTGAGTGGACAGTAGCACCTGTATCATTGAACTCATTTTGTATCAGAGCA
 721 ATTTTGCTTGCAGAAAGCTATGAAATAAAACACGTCCCTTAACTGCATTGCTATGGAATTAATTTTTTTTCCCCAGGGAA
 801 AACTAGTGTATTTTTTTATGAGCAATATCAATTTGGAGTGACCAAAAGATACTTAAAAATGGGTTTATTTTGATTTCTCA
 881 TCTGAAATAATCATGTTCTGGTATTATATCTATCTATATTTAATAAATATATACATTTTAATTTATTATGTGTACTCACA
 961 TACTATAGAAAGATATTAGTATGCATTTAATAAAACATATTCACTTGAATATATGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGUCUCGGGA---GACUCG-AAGUc 5'
            || :|||||   :||||| ||:| 
Target 5' acCAAGGCCCTTCCTTGAGCATTTAt 3'
 14 - 39 124.00 -17.00
2 
miRNA  3' uaGUCUC--GGGAGAC--UC---GAAGUc 5'
            |||||  |:| | |  ||   ||||| 
Target 5' gaCAGAGAACTCACAGGAAGTTACTTCAa 3'
 491 - 519 112.00 -13.40
3 
miRNA  3' uagUCUCGGGAGACUCGAAGUc 5'
             |||| |    |||:|| | 
Target 5' gcaAGAGGC----GAGTTTAAa 3'
 92 - 109 105.00 -7.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30173376 30 COSMIC
COSN31546666 36 COSMIC
COSN30170815 51 COSMIC
COSN30539405 54 COSMIC
COSN30170806 55 COSMIC
COSN31500291 66 COSMIC
COSN5851482 67 COSMIC
COSN30481809 79 COSMIC
COSN30480558 113 COSMIC
COSN20066914 119 COSMIC
COSN22455353 143 COSMIC
COSN18730565 162 COSMIC
COSN31597528 199 COSMIC
COSN15668361 211 COSMIC
COSN14692486 391 COSMIC
COSN27668857 544 COSMIC
COSN26679242 763 COSMIC
COSN31962641 901 COSMIC
COSN31609479 937 COSMIC
COSN26557413 959 COSMIC
rs79455288 253 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs768572908 5 dbSNP
rs1350113460 11 dbSNP
rs761169233 12 dbSNP
rs776966911 14 dbSNP
rs1161034902 16 dbSNP
rs375622195 20 dbSNP
rs767445108 26 dbSNP
rs779478186 30 dbSNP
rs1445976754 34 dbSNP
rs1259015278 35 dbSNP
rs758066256 38 dbSNP
rs750052381 41 dbSNP
rs1433986201 46 dbSNP
rs1485821725 48 dbSNP
rs1003347545 54 dbSNP
rs1159293902 55 dbSNP
rs1364941264 62 dbSNP
rs892642190 65 dbSNP
rs1185509493 66 dbSNP
rs372784136 66 dbSNP
rs576431308 67 dbSNP
rs1295142541 76 dbSNP
rs936924815 83 dbSNP
rs925524863 84 dbSNP
rs1447808497 92 dbSNP
rs183265598 99 dbSNP
rs980439707 101 dbSNP
rs947722160 103 dbSNP
rs1378515666 104 dbSNP
rs1240301428 109 dbSNP
rs1247464266 119 dbSNP
rs1290380460 125 dbSNP
rs1023353247 131 dbSNP
rs1187075780 137 dbSNP
rs1267617154 147 dbSNP
rs917690539 153 dbSNP
rs995386312 156 dbSNP
rs536235549 161 dbSNP
rs1236620489 162 dbSNP
rs1441758302 164 dbSNP
rs1036860215 170 dbSNP
rs1179405679 170 dbSNP
rs565992623 174 dbSNP
rs1464874592 184 dbSNP
rs1263475603 187 dbSNP
rs1402090889 193 dbSNP
rs554105582 201 dbSNP
rs961791072 206 dbSNP
rs932364292 211 dbSNP
rs920945556 219 dbSNP
rs1043745825 248 dbSNP
rs747080141 249 dbSNP
rs79455288 253 dbSNP
rs1293574015 255 dbSNP
rs952061663 257 dbSNP
rs1028904918 264 dbSNP
rs1236993842 266 dbSNP
rs1471824053 267 dbSNP
rs996888275 276 dbSNP
rs964020701 281 dbSNP
rs1477446618 283 dbSNP
rs549957580 288 dbSNP
rs928770144 296 dbSNP
rs1425419146 297 dbSNP
rs981556837 300 dbSNP
rs571698018 305 dbSNP
rs1023005356 306 dbSNP
rs1449632704 312 dbSNP
rs1383301540 316 dbSNP
rs1302892175 319 dbSNP
rs1380606118 328 dbSNP
rs1364644402 331 dbSNP
rs1008749703 336 dbSNP
rs1436126222 337 dbSNP
rs1320382869 344 dbSNP
rs1278135073 346 dbSNP
rs1366581451 346 dbSNP
rs1440880708 347 dbSNP
rs1212397533 354 dbSNP
rs531459570 356 dbSNP
rs193262234 363 dbSNP
rs567219435 364 dbSNP
rs1428028314 368 dbSNP
rs1389661566 381 dbSNP
rs1191344135 404 dbSNP
rs1425535187 405 dbSNP
rs1478000854 407 dbSNP
rs796157075 407 dbSNP
rs1053044077 410 dbSNP
rs1422678825 418 dbSNP
rs116715387 421 dbSNP
rs1004061524 428 dbSNP
rs1359277664 440 dbSNP
rs1399951326 442 dbSNP
rs1265097003 455 dbSNP
rs527283492 472 dbSNP
rs559657091 478 dbSNP
rs899576004 484 dbSNP
rs1343219056 490 dbSNP
rs558275128 494 dbSNP
rs917595473 499 dbSNP
rs1279437131 520 dbSNP
rs1353014594 526 dbSNP
rs1056032833 528 dbSNP
rs1488562399 536 dbSNP
rs755891035 544 dbSNP
rs1053381427 552 dbSNP
rs1478810092 558 dbSNP
rs1370767068 559 dbSNP
rs747986501 579 dbSNP
rs140174393 584 dbSNP
rs1417277593 590 dbSNP
rs565158593 591 dbSNP
rs1340973005 606 dbSNP
rs1363061977 608 dbSNP
rs1251406947 612 dbSNP
rs982015177 621 dbSNP
rs1329653171 622 dbSNP
rs1438904065 626 dbSNP
rs1281918579 627 dbSNP
rs951908413 628 dbSNP
rs1238114972 632 dbSNP
rs921867708 640 dbSNP
rs41271848 642 dbSNP
rs1209101241 643 dbSNP
rs965930333 646 dbSNP
rs1221896267 655 dbSNP
rs576515609 659 dbSNP
rs554743209 668 dbSNP
rs962702376 672 dbSNP
rs1380303805 678 dbSNP
rs1470806031 681 dbSNP
rs543055153 682 dbSNP
rs1389063307 688 dbSNP
rs1407474734 695 dbSNP
rs572339946 701 dbSNP
rs1326964958 702 dbSNP
rs1399913065 715 dbSNP
rs765337905 716 dbSNP
rs1008197550 718 dbSNP
rs957041226 726 dbSNP
rs1311565952 730 dbSNP
rs1031082207 732 dbSNP
rs1375983389 738 dbSNP
rs1001464929 740 dbSNP
rs147960759 753 dbSNP
rs188367907 754 dbSNP
rs1175333143 755 dbSNP
rs1381326248 770 dbSNP
rs1257178833 780 dbSNP
rs1456222399 782 dbSNP
rs1200074033 783 dbSNP
rs1238273546 790 dbSNP
rs1441294099 791 dbSNP
rs997074324 791 dbSNP
rs1367281268 795 dbSNP
rs1474049771 800 dbSNP
rs1045179656 802 dbSNP
rs1179687958 804 dbSNP
rs1333560570 806 dbSNP
rs1397346099 807 dbSNP
rs899607989 808 dbSNP
rs1022073568 811 dbSNP
rs571540607 817 dbSNP
rs1233821319 818 dbSNP
rs564559694 818 dbSNP
rs778570158 819 dbSNP
rs1250714935 821 dbSNP
rs556410193 821 dbSNP
rs537632090 822 dbSNP
rs386701456 823 dbSNP
rs545265415 824 dbSNP
rs1012471205 828 dbSNP
rs1251570778 833 dbSNP
rs1343821188 835 dbSNP
rs1482023995 836 dbSNP
rs896703351 842 dbSNP
rs1254869946 847 dbSNP
rs1257652639 851 dbSNP
rs1486941470 852 dbSNP
rs1056541102 861 dbSNP
rs1189198770 867 dbSNP
rs567385337 872 dbSNP
rs1052061342 877 dbSNP
rs534574076 879 dbSNP
rs907653796 889 dbSNP
rs1173238350 890 dbSNP
rs1048783725 894 dbSNP
rs1373904232 901 dbSNP
rs1465720744 908 dbSNP
rs930499751 908 dbSNP
rs1324831899 911 dbSNP
rs183822595 912 dbSNP
rs974535967 914 dbSNP
rs1045930248 918 dbSNP
rs948880918 922 dbSNP
rs1338294691 927 dbSNP
rs1401667454 929 dbSNP
rs1296006849 931 dbSNP
rs1311315499 932 dbSNP
rs1230527891 933 dbSNP
rs1257255758 934 dbSNP
rs1347913436 938 dbSNP
rs1212270836 948 dbSNP
rs916054830 948 dbSNP
rs1308046554 950 dbSNP
rs1188719477 952 dbSNP
rs1262863393 962 dbSNP
rs974139402 964 dbSNP
rs1400211278 966 dbSNP
rs1336119840 969 dbSNP
rs1470275469 972 dbSNP
rs1408135118 979 dbSNP
rs566132688 980 dbSNP
rs550931171 981 dbSNP
rs941412574 995 dbSNP
rs944615516 1000 dbSNP
rs777743507 1007 dbSNP
rs1156695879 1008 dbSNP
rs1158102055 1009 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.635 4.3e-4 0.620 6.2e-4 24 Click to see details
GSE21687 Ependynoma primary tumors -0.398 5.6e-4 -0.529 3.5e-6 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.392 4.4e-2 -0.480 1.6e-2 20 Click to see details
GSE19350 CNS germ cell tumors 0.369 1.2e-1 0.423 8.5e-2 12 Click to see details
GSE19783 ER- ER- breast cancer -0.122 1.4e-1 -0.267 8.7e-3 79 Click to see details
GSE38226 Liver fibrosis 0.228 1.6e-1 0.179 2.2e-1 21 Click to see details
GSE19536 Breast cancer -0.096 1.7e-1 -0.210 1.8e-2 100 Click to see details
GSE28260 Renal cortex and medulla 0.284 1.7e-1 0.544 2.7e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells -0.171 2.1e-1 -0.162 2.2e-1 24 Click to see details
GSE17498 Multiple myeloma -0.098 2.7e-1 -0.144 1.9e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells -0.131 2.8e-1 -0.027 4.5e-1 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.102 3.1e-1 0.156 2.3e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.086 3.2e-1 -0.004 4.9e-1 32 Click to see details
GSE19783 ER+ ER+ breast cancer 0.041 4.3e-1 0.102 3.3e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer 0.041 4.3e-1 0.102 3.3e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.471 0 0.509 0 59 Click to see details
KICH 0.448 0.01 0.509 0 25 Click to see details
LUSC -0.357 0.01 -0.342 0.02 38 Click to see details
KIRC 0.204 0.05 0.168 0.09 68 Click to see details
ESCA -0.507 0.06 -0.445 0.09 11 Click to see details
CESC -0.935 0.12 -1.000 0.5 3 Click to see details
PAAD 0.758 0.12 0.800 0.1 4 Click to see details
PRAD -0.121 0.2 -0.060 0.34 50 Click to see details
KIRP 0.129 0.24 0.086 0.32 32 Click to see details
HNSC 0.111 0.24 0.047 0.38 42 Click to see details
STAD -0.121 0.25 -0.090 0.31 32 Click to see details
BRCA 0.061 0.29 0.024 0.41 84 Click to see details
LUAD 0.168 0.3 0.357 0.13 12 Click to see details
COAD -0.217 0.3 -0.548 0.08 8 Click to see details
PCPG 0.256 0.42 0.500 0.33 3 Click to see details
BLCA -0.044 0.43 -0.179 0.24 18 Click to see details
CHOL -0.032 0.47 -0.050 0.45 9 Click to see details
UCEC -0.012 0.48 0.000 0.5 19 Click to see details
LIHC 0.004 0.49 0.044 0.38 49 Click to see details
LIHC 0.004 0.49 0.044 0.38 49 Click to see details
LIHC 0.004 0.49 0.044 0.38 49 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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