miRTarBase - #MIRT440824


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol DGKD   
Synonyms DGKdelta, dgkd-2
Description diacylglycerol kinase delta
Transcript NM_003648   
Other Transcripts NM_152879   
Expression
Putative miRNA Targets on DGKD
3'UTR of DGKD
(miRNA target sites are highlighted)		 
>DGKD|NM_003648|3'UTR
   1 CCTCTGTCCTCTCAGCCTGTGGCCTCCACATCCCCGCCGCCGAGGCCTAGCCTCCGCCCTCTCAGCCTGTGGCCTCTGCG
  81 CCTCCTGCCACTGAGGCCCTGGGCAGATGCTGCAGCCCGCCCCCTTCTCATGGTGCTACTTCCTCTGTCAGCTACAGAAA
 161 GCCTCCGTGACACCGTCCACCAGAGCTCTGGGGTCTCGAACATAACAACACAGCTACCTTTGAAACAACACTTTCTCCAG
 241 CTCAGAGTCACCTGGGGCACATGTGTCACGGCCACTCAGCTCTCGCCCGCCTGTGCTGTGGGCCAGGGAATCCAGCGGCG
 321 TCTGGCCTCCTGGGCACTGCTTGCCTGGCCTCGTGCTTGGATTGTCCCGGGGGCTCCTCTCCGTGTGTCCTTCTGTGGCC
 401 GCACCGTGTGGCTCCGCCTCCTGGCCCCCAGCCAGTTCTCAGAAACGTGGCTGGGGCCCAGCACAGCAGCCTGCAAGGGC
 481 CCCTGTTTGTTGATGCAGCTTTTGTTGAACAAAAATCGTGCTCTTTCCTGGTTTGAAAGTAGCATGGATGTTTCCAGTCT
 561 TGTTGATTGTAATTTGACGTGAAGAGAAAAAAAAATTCCTCCTGCGTGAGCCAAGGCAGCGGGTGCTGTTTCCCAGGCGG
 641 GGAGCCCCTCCCTGGGTGTCACAGGGCCTGTGCTCCTCCCTCCTCCATCCTCTCTCCTCCCGCTCCTCCCTCCCCCCACT
 721 GTGGGCTGGGGACGCCTGCCCTTCTGTCTCCGGACGCTCTAGGCGAGTTCAGCTTGGGGTGTGAGTGAGACAGCTTGCCA
 801 GCTGCATCCCTGCAGACAGAGGATGTGTGTCCACATGAGTGTTTCTGTGTGGGAAATGCTTCCTGGCTCTGGGAAACTTT
 881 TTCTGCCCATTCTGTGGTTCCCAGGGAGCGTGGCCCTGGTGGGCCAGGGGTGGTTTGACCTCTTCAGCCCGTCCGGTGGC
 961 CTGGAGGCCGGAGGCTCTCCTGAGTGTCTGCCCCTGCAGTGGCTTCTTGTCGCCTGCTGCTGGGCGTGATGTCGCTGGAG
1041 GTGCTGGCAGGGACTCTGATTTGGTGGTCCGCGCTGCCCCTGCCCTGCCTCTGTCCTGGCTCTGAACTAGTAGATGATGG
1121 TGCCAGAGGGCAGGGAGCTCGCCTGGGGAGAGGGCTGTGCCCCGTAGGGACAGTGCCCAGGTGAAGGATGCCCCTGGTCC
1201 TCCAGGGCACTGACTTTGCCCTTTTTTCCCGTTGATAGTCATGGCTCAGAGGTGCTTGTAAATGTCTTGGGAAGAGGTTT
1281 CTGTAACCCCTGCCCTGGTGTGAGGAGGAAATGGCTCTGGCCTGGCTGCCTGGCCGTGGCTTCTCTTTGGCTCCCAAAGA
1361 GAAGGACAGTGTTGGGAGTATCTGCCGTGGCTTCTCTTTGGCTCCCAAAGAGAAGGACAGTGTTGGGAGTATCTGCCGGC
1441 GCTGTCCAGGTCCTTTAGTCAGCGTCACTCCATCTGATGTGCAGAAGCTGGGCTGCACCTGCGGGGGTGGGCATAGACCG
1521 GGCTGGGTCTGCAGCAGCCCCTGGTCCTGAGCAGGCGGCAGTGAACAGCACTGGCCCACCTCCCACTCACAGCCCCTCTG
1601 TCCCCTCTGCAGTGCACCCAGGTGGGCCCCTCTGCGTGCCTTTGGGTGCTCCCCTCTCGTGGTCGTTCTGGCCCGAGGCC
1681 CTTAGAGTATGGAGGCTGAGCCAGGCCTTGGGTTTCCCCAGCACAGCCTCCTGTCGCTGCATGCGACGTGTTGGGATTTT
1761 TGGATGAAAGACTCTCCCACGCTCTGTTGGTGGACTTAGCTGCCTCACTGGAAGTGATGTGGGTGGAAGGTGGTTGTATG
1841 TTACCTTTTCCACCTCTCATTGTTTTCCCCAGAACATTGTAGATGGGGGTTGGCAGAGGGAGAAATAAGCCAGCCACGGC
1921 AGTCGCTTGGTTTCCCAGGTGGAATGGGCTAACACAGGAGATGATGGGAACCTGTCCCGCAGTCCCTGCATGACCATTGG
2001 CCCTGCTGGCCTGGCGATGTGGGCATCCTGGGGTTCTTAGGGTCCCAGAACAAGCCCCAGGCAAGCTGGAACTTGGGTGG
2081 GGAGGGGACATGAGGAGGATAAACAGCTGACTGTGGCTTCAAGGACATCAGGGCCACCCCAAGTCCTCAGTGTCCTACTC
2161 CTGGCAAGGAGTTGGGTTTGGATCAAAAGTGTTTAAAATTAATATGTTGTCAGTGATTAGAACAACACTGTTTACATAAA
2241 AACCATTTTTCTAATTCTAACAAGTTAGAATGTGAGGAAGGAATGAACATGAGTGTTTAGGAACCTGCCCTTTGGTGCTG
2321 GGCTGGCGTCCCGCACTGGGGTGTCCTCGCTGTCTGGGGGCTGCTCTGCTGCCCCGGCCCAGGTCCCCTTGTGGTGTTGC
2401 CAGACGGGCCTCATGGTCTGCTGTGCAGAGAGAGGCAGGAAGGATCCCTGAAGAGTCTTGGAGAAAAGGTTCTGTGCCCT
2481 CAGGTGGGGCTTACCCCCTCGTATTTATAATCTTAATTTATATAGTGACCACCGTGGAAACAAACGCCTCTTGTATTGTC
2561 ATGTACATAGTCCATACCTGAGTGCTGTACATAAGTTGTTCTGTGTATAAATAAAACAAGCCTGTTTTTGATCTTCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagUCUCGGGAGAC-UCGAAGUc 5'
             | |||:  ||| :|||||| 
Target 5' taaACAGCTGACTGTGGCTTCAa 3'
 2100 - 2122 143.00 -13.60
2 
miRNA  3' uaGUCUCGGGAG--ACUCGAAGUc 5'
            |||: ||:|:  | ||| ||| 
Target 5' tcCAGGTCCTTTAGTCAGCGTCAc 3'
 1445 - 1468 130.00 -14.52
3 
miRNA  3' uagucucGGGAGAC--UCGAAGUc 5'
                 :||||||  |||| || 
Target 5' tgctactTCCTCTGTCAGCTACAg 3'
 134 - 157 129.00 -17.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31526584 3 COSMIC
COSN26439112 32 COSMIC
COSN31488515 43 COSMIC
COSN30538951 49 COSMIC
COSN24400642 57 COSMIC
COSN30111606 85 COSMIC
COSN31593870 121 COSMIC
COSN31609959 162 COSMIC
COSN6681537 167 COSMIC
COSN31589865 168 COSMIC
COSN62091 251 COSMIC
COSN31588285 273 COSMIC
COSN1235488 285 COSMIC
COSN5500150 401 COSMIC
COSN15668357 428 COSMIC
COSN20090752 552 COSMIC
COSN6681538 797 COSMIC
COSN29074743 1513 COSMIC
COSN27949695 1815 COSMIC
COSN6174693 2050 COSMIC
COSN21177658 2449 COSMIC
COSN24412682 2581 COSMIC
COSN5500151 2639 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs894245841 2 dbSNP
rs1477187720 3 dbSNP
rs1212132298 6 dbSNP
rs1174515638 8 dbSNP
rs1320257930 8 dbSNP
rs1214285465 9 dbSNP
rs746543063 9 dbSNP
rs776263762 10 dbSNP
rs984800625 16 dbSNP
rs567953266 17 dbSNP
rs1372346133 19 dbSNP
rs1391849708 24 dbSNP
rs375709979 25 dbSNP
rs768989653 28 dbSNP
rs774741480 34 dbSNP
rs779086668 34 dbSNP
rs762191617 36 dbSNP
rs553601469 37 dbSNP
rs1448606874 38 dbSNP
rs111663518 39 dbSNP
rs760810502 40 dbSNP
rs576646642 41 dbSNP
rs1481923463 42 dbSNP
rs370335489 43 dbSNP
rs556065930 44 dbSNP
rs1450228350 45 dbSNP
rs752567725 46 dbSNP
rs1195811856 50 dbSNP
rs1036533307 53 dbSNP
rs911020728 56 dbSNP
rs901860560 57 dbSNP
rs1204290881 58 dbSNP
rs555820691 59 dbSNP
rs73997605 59 dbSNP
rs1281126246 65 dbSNP
rs1028979788 67 dbSNP
rs1054587159 70 dbSNP
rs891491522 76 dbSNP
rs953609315 80 dbSNP
rs1373635275 81 dbSNP
rs1332202647 83 dbSNP
rs1367990745 93 dbSNP
rs945682670 96 dbSNP
rs1436400496 98 dbSNP
rs1011663100 111 dbSNP
rs1021499707 113 dbSNP
rs1340446120 116 dbSNP
rs1046018896 119 dbSNP
rs372579972 120 dbSNP
rs774595588 124 dbSNP
rs1171888999 128 dbSNP
rs541950641 131 dbSNP
rs928516156 131 dbSNP
rs1176877152 133 dbSNP
rs1034482841 139 dbSNP
rs959972968 141 dbSNP
rs991586749 142 dbSNP
rs887922756 143 dbSNP
rs1211971490 144 dbSNP
rs1006317889 145 dbSNP
rs751232800 148 dbSNP
rs931098760 152 dbSNP
rs562125402 153 dbSNP
rs1048099608 154 dbSNP
rs1015409228 161 dbSNP
rs940838146 162 dbSNP
rs146498314 167 dbSNP
rs997918814 168 dbSNP
rs1030303352 175 dbSNP
rs1373578855 176 dbSNP
rs1050894329 179 dbSNP
rs1454217533 182 dbSNP
rs1345930084 186 dbSNP
rs1158458358 190 dbSNP
rs955276967 194 dbSNP
rs1420206592 195 dbSNP
rs985352757 198 dbSNP
rs1255813052 199 dbSNP
rs911073094 209 dbSNP
rs1189090705 215 dbSNP
rs1259645190 224 dbSNP
rs748467614 225 dbSNP
rs1323181208 228 dbSNP
rs1273376491 232 dbSNP
rs772425160 239 dbSNP
rs1232274024 247 dbSNP
rs957180606 252 dbSNP
rs989941862 258 dbSNP
rs1021697807 261 dbSNP
rs763261880 261 dbSNP
rs967219104 262 dbSNP
rs879080742 265 dbSNP
rs1178578229 270 dbSNP
rs1396987823 278 dbSNP
rs1165975115 282 dbSNP
rs1378430155 285 dbSNP
rs998718468 286 dbSNP
rs912967904 289 dbSNP
rs1035511188 290 dbSNP
rs945764952 293 dbSNP
rs1261597819 294 dbSNP
rs1045814783 298 dbSNP
rs1469454469 302 dbSNP
rs541768521 315 dbSNP
rs960270250 317 dbSNP
rs1259765316 318 dbSNP
rs937611841 320 dbSNP
rs1055942892 321 dbSNP
rs1390879626 322 dbSNP
rs376319577 324 dbSNP
rs887974913 329 dbSNP
rs1006799986 337 dbSNP
rs1388414419 345 dbSNP
rs1373373568 348 dbSNP
rs780707765 353 dbSNP
rs915570043 354 dbSNP
rs1392473881 361 dbSNP
rs1170041979 365 dbSNP
rs1372849213 369 dbSNP
rs778166651 369 dbSNP
rs185429089 370 dbSNP
rs1168999290 372 dbSNP
rs1455960625 375 dbSNP
rs997571480 375 dbSNP
rs533652097 376 dbSNP
rs75079861 377 dbSNP
rs939760051 378 dbSNP
rs1252177652 379 dbSNP
rs1006842917 383 dbSNP
rs896505653 384 dbSNP
rs957265588 401 dbSNP
rs923459589 402 dbSNP
rs756090788 403 dbSNP
rs771320659 406 dbSNP
rs570145852 407 dbSNP
rs1331182459 412 dbSNP
rs1392153937 415 dbSNP
rs1209329599 416 dbSNP
rs967532260 417 dbSNP
rs1463438869 419 dbSNP
rs947343898 421 dbSNP
rs1376525964 425 dbSNP
rs981191254 426 dbSNP
rs1451980119 427 dbSNP
rs776907717 434 dbSNP
rs1432853347 436 dbSNP
rs1196989538 441 dbSNP
rs189935783 447 dbSNP
rs547934793 448 dbSNP
rs998948500 451 dbSNP
rs1457827802 457 dbSNP
rs909460768 458 dbSNP
rs1035967623 461 dbSNP
rs11271445 462 dbSNP
rs1343004685 462 dbSNP
rs35406613 463 dbSNP
rs942264321 464 dbSNP
rs1286855109 465 dbSNP
rs1387091646 465 dbSNP
rs1416967495 474 dbSNP
rs541698879 475 dbSNP
rs1312859297 479 dbSNP
rs1433367413 480 dbSNP
rs1036940681 482 dbSNP
rs369752551 483 dbSNP
rs565878524 485 dbSNP
rs1452610465 486 dbSNP
rs1361663228 489 dbSNP
rs1022857908 490 dbSNP
rs952393344 510 dbSNP
rs1256498199 512 dbSNP
rs182555681 516 dbSNP
rs1351861747 518 dbSNP
rs533514550 519 dbSNP
rs1350271926 522 dbSNP
rs1266421213 524 dbSNP
rs889146038 533 dbSNP
rs961149482 546 dbSNP
rs1287097565 548 dbSNP
rs1356549267 549 dbSNP
rs1007564624 551 dbSNP
rs1018236677 552 dbSNP
rs188309228 555 dbSNP
rs553663440 560 dbSNP
rs1265856443 563 dbSNP
rs1318440659 563 dbSNP
rs148844354 564 dbSNP
rs1166690529 567 dbSNP
rs1461631246 570 dbSNP
rs1416974891 572 dbSNP
rs1011451131 577 dbSNP
rs1208350821 579 dbSNP
rs1242593136 580 dbSNP
rs539348250 585 dbSNP
rs933482433 587 dbSNP
rs986803809 587 dbSNP
rs1335650718 589 dbSNP
rs1053893 595 dbSNP
rs1226923730 596 dbSNP
rs1342111886 597 dbSNP
rs981185435 599 dbSNP
rs192813853 606 dbSNP
rs1365328335 607 dbSNP
rs1327321736 612 dbSNP
rs958400577 613 dbSNP
rs991124388 621 dbSNP
rs1393197546 622 dbSNP
rs1456701500 623 dbSNP
rs1419938779 624 dbSNP
rs1167303623 625 dbSNP
rs908839233 626 dbSNP
rs942295172 630 dbSNP
rs868137909 635 dbSNP
rs972315018 639 dbSNP
rs2971873 640 dbSNP
rs1252553123 645 dbSNP
rs1057178125 646 dbSNP
rs535948595 659 dbSNP
rs1053894 667 dbSNP
rs895657207 677 dbSNP
rs753092309 679 dbSNP
rs1439956967 680 dbSNP
rs1410004168 681 dbSNP
rs1214555940 683 dbSNP
rs1340594167 691 dbSNP
rs933487294 701 dbSNP
rs767299336 703 dbSNP
rs1370500380 704 dbSNP
rs1230010141 710 dbSNP
rs1272770948 712 dbSNP
rs1313332900 713 dbSNP
rs1320968390 714 dbSNP
rs1243509969 715 dbSNP
rs1005420712 717 dbSNP
rs1051890878 718 dbSNP
rs41264147 721 dbSNP
rs943398340 727 dbSNP
rs34748605 728 dbSNP
rs1175624545 731 dbSNP
rs541471619 732 dbSNP
rs1053786980 733 dbSNP
rs368745101 734 dbSNP
rs1011921158 735 dbSNP
rs1233834723 749 dbSNP
rs533112482 752 dbSNP
rs903038011 753 dbSNP
rs953918824 756 dbSNP
rs1346578930 757 dbSNP
rs564451141 759 dbSNP
rs577429184 760 dbSNP
rs910722906 765 dbSNP
rs1035454926 766 dbSNP
rs769610795 768 dbSNP
rs947653080 773 dbSNP
rs958452397 776 dbSNP
rs1358710085 777 dbSNP
rs118004559 780 dbSNP
rs1402672004 781 dbSNP
rs756690899 781 dbSNP
rs1181936858 783 dbSNP
rs1016356956 787 dbSNP
rs924609771 792 dbSNP
rs1189356388 793 dbSNP
rs386656352 796 dbSNP
rs1053895 797 dbSNP
rs865976338 798 dbSNP
rs747277427 800 dbSNP
rs972751512 804 dbSNP
rs917367916 805 dbSNP
rs1226154844 806 dbSNP
rs919515986 807 dbSNP
rs1378363283 808 dbSNP
rs948796396 815 dbSNP
rs1450291190 817 dbSNP
rs1299581366 820 dbSNP
rs1342565785 823 dbSNP
rs1044247193 824 dbSNP
rs1376798435 830 dbSNP
rs1301204896 831 dbSNP
rs1271128216 840 dbSNP
rs1432919623 847 dbSNP
rs888269976 850 dbSNP
rs1158761804 853 dbSNP
rs753416745 859 dbSNP
rs1420548885 863 dbSNP
rs1314086632 867 dbSNP
rs1005432011 868 dbSNP
rs1254628390 873 dbSNP
rs1036868241 878 dbSNP
rs563914702 878 dbSNP
rs1246873348 879 dbSNP
rs754420993 888 dbSNP
rs556643635 892 dbSNP
rs768817448 893 dbSNP
rs1460396258 898 dbSNP
rs943450391 901 dbSNP
rs529417531 904 dbSNP
rs893827503 908 dbSNP
rs997891808 910 dbSNP
rs1297702772 911 dbSNP
rs981285483 913 dbSNP
rs548286468 919 dbSNP
rs1042064352 921 dbSNP
rs1006637147 922 dbSNP
rs561408683 923 dbSNP
rs1002707666 924 dbSNP
rs1457761593 927 dbSNP
rs1367052709 932 dbSNP
rs73997606 933 dbSNP
rs1429613106 934 dbSNP
rs758721633 939 dbSNP
rs979028485 940 dbSNP
rs924858658 941 dbSNP
rs894285716 943 dbSNP
rs1469557649 947 dbSNP
rs778240732 949 dbSNP
rs1015998352 951 dbSNP
rs143515781 952 dbSNP
rs570107191 954 dbSNP
rs963416843 955 dbSNP
rs376949355 956 dbSNP
rs539730994 957 dbSNP
rs1296973292 958 dbSNP
rs1226209809 962 dbSNP
rs993172486 963 dbSNP
rs536928958 970 dbSNP
rs549764027 971 dbSNP
rs954941573 972 dbSNP
rs1386419592 976 dbSNP
rs2971872 978 dbSNP
rs2971871 981 dbSNP
rs1370438643 991 dbSNP
rs909720661 994 dbSNP
rs964860258 998 dbSNP
rs941172102 1004 dbSNP
rs1395131792 1005 dbSNP
rs1197811388 1006 dbSNP
rs377281791 1009 dbSNP
rs555523651 1011 dbSNP
rs1036814205 1012 dbSNP
rs867515661 1012 dbSNP
rs879334155 1013 dbSNP
rs1042395003 1020 dbSNP
rs927945392 1026 dbSNP
rs938615581 1027 dbSNP
rs73997607 1034 dbSNP
rs745957160 1035 dbSNP
rs1392276834 1036 dbSNP
rs1006646988 1046 dbSNP
rs1306764360 1057 dbSNP
rs1437123410 1065 dbSNP
rs1171425358 1069 dbSNP
rs1375585925 1069 dbSNP
rs1464236794 1070 dbSNP
rs1269319046 1071 dbSNP
rs535118149 1072 dbSNP
rs1022030978 1073 dbSNP
rs1464792024 1073 dbSNP
rs1191508001 1074 dbSNP
rs1190053253 1080 dbSNP
rs1485922916 1084 dbSNP
rs1033685398 1089 dbSNP
rs769943185 1089 dbSNP
rs1343160026 1090 dbSNP
rs1262770886 1094 dbSNP
rs1229214535 1099 dbSNP
rs562305318 1100 dbSNP
rs763272555 1102 dbSNP
rs768734915 1112 dbSNP
rs113301908 1116 dbSNP
rs993477529 1118 dbSNP
rs917263323 1124 dbSNP
rs1393742383 1125 dbSNP
rs993611707 1129 dbSNP
rs1479161718 1133 dbSNP
rs969990706 1141 dbSNP
rs1025995442 1142 dbSNP
rs1158851770 1155 dbSNP
rs1456366565 1156 dbSNP
rs1409503752 1160 dbSNP
rs954330150 1164 dbSNP
rs1009180565 1165 dbSNP
rs114373033 1166 dbSNP
rs1315999467 1168 dbSNP
rs773120749 1169 dbSNP
rs1263942574 1170 dbSNP
rs1209666271 1175 dbSNP
rs941432252 1177 dbSNP
rs1266633191 1182 dbSNP
rs544096484 1185 dbSNP
rs1351373977 1191 dbSNP
rs989655792 1198 dbSNP
rs915360516 1203 dbSNP
rs1284164870 1207 dbSNP
rs1243246405 1209 dbSNP
rs1437521479 1213 dbSNP
rs1416763474 1215 dbSNP
rs1320572420 1222 dbSNP
rs1327740342 1222 dbSNP
rs563798730 1223 dbSNP
rs1385933453 1229 dbSNP
rs1327691762 1230 dbSNP
rs760385661 1231 dbSNP
rs150928285 1232 dbSNP
rs1161459451 1240 dbSNP
rs1343793696 1241 dbSNP
rs753719061 1245 dbSNP
rs1230311563 1248 dbSNP
rs1449124990 1252 dbSNP
rs542883939 1258 dbSNP
rs1215766575 1266 dbSNP
rs559520752 1272 dbSNP
rs1057018313 1276 dbSNP
rs915824088 1289 dbSNP
rs1292513781 1293 dbSNP
rs948612195 1301 dbSNP
rs1297728778 1306 dbSNP
rs1037541429 1321 dbSNP
rs898967835 1323 dbSNP
rs903627826 1336 dbSNP
rs929082746 1337 dbSNP
rs1305227966 1341 dbSNP
rs1452526006 1345 dbSNP
rs1349149174 1346 dbSNP
rs1411598741 1346 dbSNP
rs1047498773 1348 dbSNP
rs890148877 1351 dbSNP
rs527427729 1354 dbSNP
rs1479212996 1356 dbSNP
rs1031872613 1363 dbSNP
rs1008563868 1366 dbSNP
rs891923220 1377 dbSNP
rs1014509058 1380 dbSNP
rs1017904108 1382 dbSNP
rs1183732294 1387 dbSNP
rs900762886 1388 dbSNP
rs1389789504 1389 dbSNP
rs1024952970 1390 dbSNP
rs1011552136 1391 dbSNP
rs1219466263 1394 dbSNP
rs1366388457 1400 dbSNP
rs1022474765 1402 dbSNP
rs1272890212 1405 dbSNP
rs967268669 1407 dbSNP
rs978225798 1413 dbSNP
rs1415769541 1416 dbSNP
rs2971870 1417 dbSNP
rs1405737326 1420 dbSNP
rs960730094 1422 dbSNP
rs990790786 1423 dbSNP
rs962805068 1428 dbSNP
rs1411851678 1438 dbSNP
rs866416868 1438 dbSNP
rs1308743649 1439 dbSNP
rs1349911084 1441 dbSNP
rs752117518 1441 dbSNP
rs1171011795 1442 dbSNP
rs948680937 1449 dbSNP
rs1237584252 1454 dbSNP
rs563744326 1458 dbSNP
rs918430625 1461 dbSNP
rs920467901 1462 dbSNP
rs532763680 1464 dbSNP
rs929111506 1465 dbSNP
rs1311273185 1470 dbSNP
rs1047551108 1471 dbSNP
rs986750120 1476 dbSNP
rs1329676196 1480 dbSNP
rs911171482 1485 dbSNP
rs1206817157 1486 dbSNP
rs890199777 1489 dbSNP
rs550066376 1491 dbSNP
rs944404446 1494 dbSNP
rs1304680357 1496 dbSNP
rs1448906246 1497 dbSNP
rs569886428 1499 dbSNP
rs1179661343 1501 dbSNP
rs1038721173 1503 dbSNP
rs1332517569 1503 dbSNP
rs942574249 1504 dbSNP
rs1473053865 1507 dbSNP
rs900138725 1508 dbSNP
rs1471917042 1518 dbSNP
rs1011186671 1519 dbSNP
rs1162724416 1520 dbSNP
rs535718572 1521 dbSNP
rs902721865 1527 dbSNP
rs549244457 1528 dbSNP
rs1169438183 1539 dbSNP
rs773625717 1540 dbSNP
rs903513290 1541 dbSNP
rs565870795 1544 dbSNP
rs1226293246 1548 dbSNP
rs535131302 1557 dbSNP
rs990838272 1558 dbSNP
rs891980102 1564 dbSNP
rs1447881469 1567 dbSNP
rs1378606860 1590 dbSNP
rs183857534 1595 dbSNP
rs1349958833 1596 dbSNP
rs963018501 1597 dbSNP
rs1320336949 1604 dbSNP
rs1024460067 1605 dbSNP
rs973366273 1607 dbSNP
rs920504424 1613 dbSNP
rs929187668 1615 dbSNP
rs983291053 1618 dbSNP
rs571634437 1621 dbSNP
rs1338270405 1628 dbSNP
rs944451963 1628 dbSNP
rs1038788658 1630 dbSNP
rs1247079241 1633 dbSNP
rs879296274 1636 dbSNP
rs766784152 1637 dbSNP
rs1280072219 1639 dbSNP
rs1265794460 1642 dbSNP
rs757635855 1648 dbSNP
rs1182875976 1649 dbSNP
rs1241089501 1650 dbSNP
rs902773563 1652 dbSNP
rs1230644369 1653 dbSNP
rs1026122131 1654 dbSNP
rs955472080 1655 dbSNP
rs150087882 1659 dbSNP
rs1370254565 1660 dbSNP
rs866776329 1665 dbSNP
rs1294415801 1668 dbSNP
rs533366942 1675 dbSNP
rs963989823 1676 dbSNP
rs373944780 1678 dbSNP
rs979308615 1684 dbSNP
rs1389005074 1698 dbSNP
rs1056578711 1701 dbSNP
rs574277223 1707 dbSNP
rs35849001 1708 dbSNP
rs934965895 1713 dbSNP
rs756654980 1725 dbSNP
rs1487479855 1732 dbSNP
rs780227261 1736 dbSNP
rs79479131 1737 dbSNP
rs749319556 1742 dbSNP
rs949163310 1744 dbSNP
rs553163900 1745 dbSNP
rs550158821 1746 dbSNP
rs138731895 1748 dbSNP
rs570203059 1749 dbSNP
rs1386612966 1751 dbSNP
rs1038566308 1758 dbSNP
rs1345078506 1764 dbSNP
rs774373359 1765 dbSNP
rs1369413956 1767 dbSNP
rs898515709 1770 dbSNP
rs983343310 1777 dbSNP
rs1467291542 1778 dbSNP
rs746821652 1780 dbSNP
rs1174894380 1781 dbSNP
rs1253704849 1782 dbSNP
rs965850356 1782 dbSNP
rs1182885644 1802 dbSNP
rs1209134126 1805 dbSNP
rs1025627154 1807 dbSNP
rs1260715960 1816 dbSNP
rs371287118 1823 dbSNP
rs540750583 1833 dbSNP
rs974530694 1846 dbSNP
rs563805153 1847 dbSNP
rs1053899 1850 dbSNP
rs1201239933 1854 dbSNP
rs1018126812 1860 dbSNP
rs397868805 1867 dbSNP
rs1290533769 1869 dbSNP
rs946455743 1872 dbSNP
rs1350368100 1877 dbSNP
rs1305665851 1878 dbSNP
rs1397319385 1879 dbSNP
rs1043789620 1884 dbSNP
rs1301969792 1885 dbSNP
rs1464222318 1889 dbSNP
rs1413925910 1890 dbSNP
rs923609941 1897 dbSNP
rs770666203 1899 dbSNP
rs1159543293 1900 dbSNP
rs1472235393 1901 dbSNP
rs1551409 1903 dbSNP
rs1409723755 1906 dbSNP
rs1053901 1909 dbSNP
rs1189490401 1910 dbSNP
rs188747407 1912 dbSNP
rs1256938537 1916 dbSNP
rs1174284380 1917 dbSNP
rs1460095839 1918 dbSNP
rs192633342 1919 dbSNP
rs141876875 1920 dbSNP
rs1209699100 1922 dbSNP
rs183542960 1925 dbSNP
rs956635305 1926 dbSNP
rs1247627595 1935 dbSNP
rs1458185828 1939 dbSNP
rs950816041 1943 dbSNP
rs1311318907 1946 dbSNP
rs898581956 1980 dbSNP
rs1390321437 1991 dbSNP
rs988252988 1992 dbSNP
rs1456540607 1996 dbSNP
rs1386171387 1998 dbSNP
rs917584692 2000 dbSNP
rs949169039 2002 dbSNP
rs995564673 2006 dbSNP
rs1026084064 2017 dbSNP
rs882428 2018 dbSNP
rs565883420 2020 dbSNP
rs368678466 2032 dbSNP
rs1464781017 2034 dbSNP
rs7567707 2035 dbSNP
rs1212170857 2036 dbSNP
rs1357592806 2043 dbSNP
rs775132436 2059 dbSNP
rs1264387318 2062 dbSNP
rs41264149 2078 dbSNP
rs1222375811 2085 dbSNP
rs549082086 2092 dbSNP
rs1433888029 2096 dbSNP
rs551286995 2097 dbSNP
rs1325202690 2099 dbSNP
rs537528819 2101 dbSNP
rs1389867149 2102 dbSNP
rs1047539166 2106 dbSNP
rs891094034 2110 dbSNP
rs1392097310 2112 dbSNP
rs1331165868 2116 dbSNP
rs1189522176 2117 dbSNP
rs1449033794 2121 dbSNP
rs1240727184 2123 dbSNP
rs921749743 2123 dbSNP
rs557118882 2127 dbSNP
rs979178384 2129 dbSNP
rs923628720 2132 dbSNP
rs1220896845 2133 dbSNP
rs763820131 2135 dbSNP
rs1343744963 2136 dbSNP
rs1018346043 2139 dbSNP
rs963883793 2153 dbSNP
rs1336996118 2155 dbSNP
rs1276418347 2162 dbSNP
rs934977705 2162 dbSNP
rs1330267995 2164 dbSNP
rs1301290899 2166 dbSNP
rs992406801 2167 dbSNP
rs1411572996 2177 dbSNP
rs918159014 2182 dbSNP
rs1000727982 2189 dbSNP
rs1169232079 2190 dbSNP
rs1409644921 2191 dbSNP
rs1484763596 2193 dbSNP
rs1032157077 2199 dbSNP
rs188033264 2203 dbSNP
rs1377406899 2205 dbSNP
rs1197906590 2207 dbSNP
rs988043072 2209 dbSNP
rs1045642276 2211 dbSNP
rs1268322597 2213 dbSNP
rs536552193 2219 dbSNP
rs1490230741 2221 dbSNP
rs898639449 2223 dbSNP
rs1197387128 2229 dbSNP
rs1251944055 2237 dbSNP
rs931402527 2251 dbSNP
rs970398687 2259 dbSNP
rs1047125014 2260 dbSNP
rs1344109740 2262 dbSNP
rs980502047 2262 dbSNP
rs926404002 2271 dbSNP
rs145431349 2285 dbSNP
rs536660707 2289 dbSNP
rs573117257 2290 dbSNP
rs545232436 2291 dbSNP
rs1308741499 2296 dbSNP
rs1008225090 2299 dbSNP
rs1441615153 2300 dbSNP
rs1473225954 2314 dbSNP
rs1158985728 2315 dbSNP
rs1019594033 2319 dbSNP
rs1362483310 2327 dbSNP
rs901765391 2328 dbSNP
rs866674636 2329 dbSNP
rs1459768163 2331 dbSNP
rs1429032797 2333 dbSNP
rs930227958 2334 dbSNP
rs1365826559 2335 dbSNP
rs559086006 2337 dbSNP
rs1413406565 2341 dbSNP
rs1029258392 2342 dbSNP
rs1300782188 2349 dbSNP
rs967891702 2350 dbSNP
rs1210403107 2354 dbSNP
rs1441418233 2357 dbSNP
rs757725591 2358 dbSNP
rs1039711364 2359 dbSNP
rs1224318656 2360 dbSNP
rs1030703826 2373 dbSNP
rs79032428 2376 dbSNP
rs1371288004 2377 dbSNP
rs1314986084 2378 dbSNP
rs1032599580 2380 dbSNP
rs1405557975 2381 dbSNP
rs1334942609 2383 dbSNP
rs1459194136 2390 dbSNP
rs1246733502 2391 dbSNP
rs1389838492 2391 dbSNP
rs1292167511 2392 dbSNP
rs892262133 2401 dbSNP
rs556532127 2406 dbSNP
rs543494055 2407 dbSNP
rs1254129941 2411 dbSNP
rs1483418139 2413 dbSNP
rs917543275 2417 dbSNP
rs1024863797 2424 dbSNP
rs971038413 2431 dbSNP
rs1190105493 2433 dbSNP
rs980429718 2439 dbSNP
rs546190533 2442 dbSNP
rs948325287 2445 dbSNP
rs1267190866 2455 dbSNP
rs1033305430 2458 dbSNP
rs1177205359 2460 dbSNP
rs981017738 2463 dbSNP
rs963130477 2475 dbSNP
rs920111852 2479 dbSNP
rs931497037 2484 dbSNP
rs1382084254 2485 dbSNP
rs1313277862 2486 dbSNP
rs750791747 2487 dbSNP
rs1366395156 2491 dbSNP
rs973091665 2491 dbSNP
rs1426017793 2493 dbSNP
rs1352078776 2494 dbSNP
rs920090486 2494 dbSNP
rs1047625569 2496 dbSNP
rs1384961688 2497 dbSNP
rs138065677 2501 dbSNP
rs369489240 2502 dbSNP
rs1371943169 2510 dbSNP
rs1442304929 2513 dbSNP
rs944250716 2516 dbSNP
rs528832393 2518 dbSNP
rs1041086770 2530 dbSNP
rs1053999 2532 dbSNP
rs1489326244 2534 dbSNP
rs899807786 2535 dbSNP
rs1397668823 2538 dbSNP
rs1315516342 2540 dbSNP
rs996528460 2546 dbSNP
rs1039765040 2547 dbSNP
rs753406797 2547 dbSNP
rs1358891128 2549 dbSNP
rs1289611269 2551 dbSNP
rs1343093399 2558 dbSNP
rs2026 2561 dbSNP
rs1380936303 2563 dbSNP
rs1244124395 2568 dbSNP
rs903722041 2569 dbSNP
rs1277036745 2578 dbSNP
rs1363169719 2584 dbSNP
rs1308234403 2586 dbSNP
rs1309271870 2591 dbSNP
rs936743738 2592 dbSNP
rs1053854277 2597 dbSNP
rs376803317 2604 dbSNP
rs1030756296 2609 dbSNP
rs1484544905 2613 dbSNP
rs1182919544 2614 dbSNP
rs1489820490 2617 dbSNP
rs536324378 2621 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.614 9.1e-4 0.319 6.9e-2 23 Click to see details
GSE17498 Multiple myeloma 0.263 5.1e-2 0.088 2.9e-1 40 Click to see details
GSE28544 Breast cancer -0.316 6.6e-2 -0.288 8.6e-2 24 Click to see details
GSE19350 CNS germ cell tumors -0.203 2.6e-1 -0.003 5.0e-1 12 Click to see details
GSE19536 Breast cancer -0.064 2.6e-1 -0.051 3.1e-1 100 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.127 2.7e-1 0.038 4.3e-1 25 Click to see details
GSE38226 Liver fibrosis 0.132 2.8e-1 0.069 3.8e-1 21 Click to see details
GSE28260 Renal cortex and medulla -0.165 3.0e-1 -0.440 6.6e-2 13 Click to see details
GSE19783 ER+ ER+ breast cancer -0.115 3.1e-1 -0.020 4.7e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.093 3.3e-1 0.094 3.3e-1 24 Click to see details
GSE21687 Ependynoma primary tumors -0.053 3.4e-1 -0.054 3.4e-1 64 Click to see details
GSE32688 Pancreatic cancer -0.058 3.8e-1 -0.014 4.7e-1 32 Click to see details
GSE19783 ER- ER- breast cancer -0.017 4.4e-1 -0.028 4.0e-1 79 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.01 4.8e-1 0.296 1.0e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.01 4.8e-1 0.296 1.0e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC 0.251 0.02 0.181 0.07 68 Click to see details
KICH 0.289 0.08 0.245 0.12 25 Click to see details
BLCA -0.329 0.09 -0.356 0.07 18 Click to see details
COAD 0.508 0.1 0.571 0.07 8 Click to see details
PCPG -0.92 0.13 -1.000 0.5 3 Click to see details
CESC 0.914 0.13 0.500 0.33 3 Click to see details
LUAD -0.333 0.15 -0.175 0.29 12 Click to see details
PRAD -0.143 0.16 -0.152 0.15 50 Click to see details
PAAD -0.669 0.17 -0.600 0.2 4 Click to see details
KIRP 0.175 0.17 0.195 0.14 32 Click to see details
HNSC 0.146 0.18 0.173 0.14 42 Click to see details
LUSC -0.141 0.2 -0.297 0.04 38 Click to see details
LIHC 0.123 0.2 0.187 0.1 49 Click to see details
ESCA 0.213 0.26 0.236 0.24 11 Click to see details
STAD -0.093 0.31 -0.148 0.21 32 Click to see details
UCEC 0.119 0.31 0.172 0.24 19 Click to see details
BRCA 0.039 0.36 0.049 0.33 84 Click to see details
CHOL 0.09 0.41 0.017 0.48 9 Click to see details
THCA -0.008 0.48 -0.031 0.41 59 Click to see details
THCA -0.008 0.48 -0.031 0.41 59 Click to see details
THCA -0.008 0.48 -0.031 0.41 59 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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