miRTarBase - #MIRT440914


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol COPA   
Synonyms AILJK, HEP-COP
Description coatomer protein complex subunit alpha
Transcript NM_001098398   
Other Transcripts NM_004371   
Expression
Putative miRNA Targets on COPA
3'UTR of COPA
(miRNA target sites are highlighted)		 
>COPA|NM_001098398|3'UTR
   1 GGCCCCCTTTGTGTGCATGGGTCAGTCACCATATGTTCCCCCCAGAGAATGTGTCTATATCCTCCTTCTAACAGCACCTT
  81 CCCCCTGCAGCTACTCTTCAGATCTGGCTCTCTGTACCCTAAAACCTAGTATCTTTTTCTCTTCTATGGAAAATCCGAAG
 161 GTCTAAACTTGACTTTTTTGAGGTCTTCTCAACTTGACTACAGTTGTGCTCATAATTGTCCTTGCCTTTCCAGCTTAATT
 241 ATTTTAAGGAACAAATGAAAACTCTGGGCTGGGTGGAGTGGCTCATACCTGTAATCCCAGCACTTTGGGAGGCTACGGTG
 321 GGCAGATCATCTGAGGCCAGGAGTTCGAGACCTGCCTGGCCAACATGGCAACACCCCGTCTCTAATAAAAATATAAAAAT
 401 TAGCCTGGCATGGTAGCATGCGCCTATAGTCCCAGCTGCTCAGGAGGCTGAGGCATGAGAATCGCTTGAACCTAGGAGGT
 481 GGAGGTTGCATTCAACTGAGATCATACCACTTCATTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCAAAAAAAAAAAA
 561 AAGGAAAACTCTGTGATGGACATTTGTTTAGTAAATCCCTTCAGTATTTATCCCTCCTTTCCCCACAGCAGCTTTCTTTC
 641 CTGTCAACTAGAAAGGAGCAGGATGTAATAAATACATTTTGGTGTGACTAGGCCACACCAACTCTTAATCATCTCCCATT
 721 TTCCTTAGACATTTAAATTTCAAGGCAGGTACCCTCTGTGTACTCAGAAATTTGAAGAAGTTATTTGGTTTTCCAAAATG
 801 CACACTGCGGGTTATTGATTTGTTCTTTACAACTATTGTTCTCATATTTCTCACACTAAATAAATCTCTATGAGAGCTTC
 881 TTGACTTGGCCATTTATTTCTTGGACACTCTCATGTTCTTGTTCACCCATGCAGGCACCCCACCAAAGTACATATCTTCC
 961 TTCCAGTAATAATTTTTAATTACAAAATAAACATCCACTATTGGAAAAAAAAAAAAAAAGCTAGCCGGGCATGGTGGTGG
1041 GTGCCTGTAATCCCAGCTACTCTGGAGGCTGAGGCAGAGGATTGCTTGAACCCGGGAGGCGGAGGTTGCAGTAAGCTGAG
1121 ATCGCGCCACCGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAAAAAAAAAGAAAGAAAAAAAGAAGCACATGT
1201 TTTTCATAGGGTATATATGAGGACCTAAACTGCTGTGAAAATGATAGAAAGCAAGTAGCTCCCTTATTCTGTTTTTGATT
1281 GCAGCCTTTTATCTTTTGCTAATTATAGCAATATTTATTGAGCACCTGCCATGTGACTGTCACTGTTCTAGATATTTTAC
1361 ATGTAATATACAGATAAAAGAATAGTACTTTATATATATTACAATGATACAATGATTACATTAACAATACAATATTTTGC
1441 TTGTCATATGCTAAGAATAATTGGGTAGAGTGACATTACTGTGCCTTCGATTAAAATAAGTACTTTTTTGCGTGTTAAAT
1521 TCATGTTTTCAATAAATAATAAATGCATATAGTTGAAAAATCAGTAAATA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGUCUCGGGAGA--CUCGAAGuc 5'
            :| | |:|| |  |||||||  
Target 5' aaTAAATCTCTATGAGAGCTTCtt 3'
 859 - 882 138.00 -12.70
2 
miRNA  3' uagucuCGGGAGACUCGAAGUc 5'
                |||:|:  ||||| | 
Target 5' gtccttGCCTTTCCAGCTTAAt 3'
 218 - 239 124.00 -10.52
3 
miRNA  3' uagucucGGGAGAC-UCGAAGuc 5'
                 ||| | | |||||:  
Target 5' tcctttcCCCACAGCAGCTTTct 3'
 615 - 637 115.00 -12.09
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30541544 3 COSMIC
COSN26971561 28 COSMIC
COSN30482524 29 COSMIC
COSN18724788 38 COSMIC
COSN26971559 39 COSMIC
COSN30529139 46 COSMIC
COSN30464014 61 COSMIC
COSN30535703 62 COSMIC
COSN30156519 81 COSMIC
COSN30462853 84 COSMIC
COSN30529152 89 COSMIC
COSN31500612 95 COSMIC
COSN31582339 128 COSMIC
COSN28192095 151 COSMIC
COSN30506920 160 COSMIC
COSN30105851 196 COSMIC
COSN31493705 217 COSMIC
COSN30116304 226 COSMIC
COSN20850391 333 COSMIC
COSN5865462 346 COSMIC
COSN30171730 347 COSMIC
COSN8645637 595 COSMIC
COSN26804508 644 COSMIC
COSN8645636 669 COSMIC
COSN21128641 682 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773805961 3 dbSNP
rs1218903648 5 dbSNP
rs770155815 6 dbSNP
rs1367399958 11 dbSNP
rs748562621 17 dbSNP
rs535699604 21 dbSNP
rs1245830781 31 dbSNP
rs769007832 32 dbSNP
rs745581082 33 dbSNP
rs1463400571 34 dbSNP
rs1246366204 36 dbSNP
rs778517512 37 dbSNP
rs200071788 38 dbSNP
rs777788254 39 dbSNP
rs1192365448 41 dbSNP
rs192179731 43 dbSNP
rs1309831458 44 dbSNP
rs1438954446 45 dbSNP
rs1366717822 47 dbSNP
rs1159213309 49 dbSNP
rs1381900648 53 dbSNP
rs1403444803 54 dbSNP
rs548159687 55 dbSNP
rs533080502 64 dbSNP
rs1373571451 68 dbSNP
rs1438879856 81 dbSNP
rs1296461663 82 dbSNP
rs1376278759 89 dbSNP
rs1448113725 96 dbSNP
rs531161196 107 dbSNP
rs931248114 108 dbSNP
rs1381024267 110 dbSNP
rs1028274644 114 dbSNP
rs1461083153 117 dbSNP
rs1401332580 119 dbSNP
rs1228181066 120 dbSNP
rs1169915799 125 dbSNP
rs1321886855 128 dbSNP
rs774816658 135 dbSNP
rs1255560256 146 dbSNP
rs1456963750 156 dbSNP
rs547416247 157 dbSNP
rs1199469095 160 dbSNP
rs964022038 164 dbSNP
rs1414270574 176 dbSNP
rs1443916064 182 dbSNP
rs1455540861 192 dbSNP
rs1168834009 200 dbSNP
rs1399597746 201 dbSNP
rs1250830608 203 dbSNP
rs878890759 205 dbSNP
rs1333950591 216 dbSNP
rs1404464378 223 dbSNP
rs1447966503 235 dbSNP
rs1285102545 240 dbSNP
rs527281710 245 dbSNP
rs1229646926 263 dbSNP
rs1275962492 266 dbSNP
rs561307050 266 dbSNP
rs1004276803 267 dbSNP
rs887194341 276 dbSNP
rs1259434689 292 dbSNP
rs1440566318 305 dbSNP
rs1274639942 312 dbSNP
rs1237795293 315 dbSNP
rs986915007 316 dbSNP
rs1338171829 317 dbSNP
rs1256089717 318 dbSNP
rs1235574044 327 dbSNP
rs1024278007 328 dbSNP
rs956480401 333 dbSNP
rs1423181575 346 dbSNP
rs749704787 347 dbSNP
rs1414363055 348 dbSNP
rs542917767 351 dbSNP
rs1335497410 359 dbSNP
rs189630787 365 dbSNP
rs1032289975 372 dbSNP
rs1295956970 376 dbSNP
rs373471631 378 dbSNP
rs1000759850 382 dbSNP
rs1279481264 384 dbSNP
rs1342295405 385 dbSNP
rs1218539308 386 dbSNP
rs904669120 393 dbSNP
rs756649409 396 dbSNP
rs1336764354 410 dbSNP
rs185544068 412 dbSNP
rs1389947387 413 dbSNP
rs543641017 415 dbSNP
rs1375967586 417 dbSNP
rs1395785308 420 dbSNP
rs746512661 421 dbSNP
rs578071830 426 dbSNP
rs1173235546 436 dbSNP
rs1418410393 442 dbSNP
rs1436458959 445 dbSNP
rs1051193569 456 dbSNP
rs557970040 460 dbSNP
rs770970773 463 dbSNP
rs541472365 464 dbSNP
rs1012881879 477 dbSNP
rs140583139 481 dbSNP
rs1179159511 485 dbSNP
rs1241123317 490 dbSNP
rs1035693714 493 dbSNP
rs1003406305 494 dbSNP
rs975383799 495 dbSNP
rs1256192449 496 dbSNP
rs1354201647 497 dbSNP
rs1219046581 498 dbSNP
rs962638725 500 dbSNP
rs1046955082 503 dbSNP
rs1451102983 507 dbSNP
rs1199586611 510 dbSNP
rs931110915 522 dbSNP
rs1212431836 525 dbSNP
rs146809087 529 dbSNP
rs1178597334 535 dbSNP
rs1381273107 536 dbSNP
rs1421953611 543 dbSNP
rs113396177 546 dbSNP
rs1159923217 547 dbSNP
rs1003598637 548 dbSNP
rs1234284322 549 dbSNP
rs200209464 550 dbSNP
rs200545004 562 dbSNP
rs1308510104 563 dbSNP
rs397798285 563 dbSNP
rs571199695 563 dbSNP
rs5778156 563 dbSNP
rs796472715 563 dbSNP
rs1377349061 568 dbSNP
rs1241006109 572 dbSNP
rs1351834332 573 dbSNP
rs1355835757 581 dbSNP
rs909678955 585 dbSNP
rs192606272 603 dbSNP
rs1281649173 606 dbSNP
rs951435912 611 dbSNP
rs1335426611 612 dbSNP
rs569949794 614 dbSNP
rs187468896 616 dbSNP
rs202181876 617 dbSNP
rs1373784152 622 dbSNP
rs758003340 636 dbSNP
rs986474710 638 dbSNP
rs1420250208 645 dbSNP
rs1163523514 656 dbSNP
rs1396006426 658 dbSNP
rs375888707 664 dbSNP
rs935102755 665 dbSNP
rs1400856904 668 dbSNP
rs1034778344 677 dbSNP
rs1000426487 679 dbSNP
rs1310252879 681 dbSNP
rs904785596 683 dbSNP
rs977576571 684 dbSNP
rs1469265928 706 dbSNP
rs16831746 712 dbSNP
rs570566404 716 dbSNP
rs1258813228 718 dbSNP
rs1021836685 724 dbSNP
rs1484401059 725 dbSNP
rs1256260925 728 dbSNP
rs528643210 766 dbSNP
rs992191290 767 dbSNP
rs1187803733 780 dbSNP
rs1419667353 784 dbSNP
rs958980852 787 dbSNP
rs1210722246 798 dbSNP
rs1448083090 801 dbSNP
rs1010392790 808 dbSNP
rs1203776497 809 dbSNP
rs1002858291 811 dbSNP
rs1396447786 823 dbSNP
rs887209469 826 dbSNP
rs1338638836 830 dbSNP
rs775607993 831 dbSNP
rs545745580 832 dbSNP
rs1278878831 837 dbSNP
rs995347826 843 dbSNP
rs1231686875 844 dbSNP
rs1255988210 872 dbSNP
rs1050887229 876 dbSNP
rs1213386344 878 dbSNP
rs933637071 880 dbSNP
rs144114639 883 dbSNP
rs1192517670 886 dbSNP
rs1263234274 891 dbSNP
rs1235436603 908 dbSNP
rs1173852376 910 dbSNP
rs1377066384 912 dbSNP
rs1466491516 924 dbSNP
rs116597781 930 dbSNP
rs1358425117 938 dbSNP
rs891031893 939 dbSNP
rs941224983 940 dbSNP
rs909834555 945 dbSNP
rs1299084232 949 dbSNP
rs78390484 951 dbSNP
rs1431337221 952 dbSNP
rs547750782 954 dbSNP
rs923704356 959 dbSNP
rs951219633 959 dbSNP
rs1237169402 971 dbSNP
rs1316195053 975 dbSNP
rs1353482491 977 dbSNP
rs917309807 978 dbSNP
rs979115001 983 dbSNP
rs905255294 988 dbSNP
rs1188878230 989 dbSNP
rs868729852 996 dbSNP
rs1266083072 998 dbSNP
rs1395029255 1004 dbSNP
rs397725034 1005 dbSNP
rs754357690 1005 dbSNP
rs1166629254 1006 dbSNP
rs113810108 1020 dbSNP
rs58191159 1020 dbSNP
rs767937535 1020 dbSNP
rs559896279 1026 dbSNP
rs560008153 1027 dbSNP
rs1045235906 1035 dbSNP
rs1368432546 1043 dbSNP
rs991661506 1056 dbSNP
rs959059306 1062 dbSNP
rs563620387 1065 dbSNP
rs544043758 1066 dbSNP
rs1241412337 1074 dbSNP
rs1286785243 1074 dbSNP
rs1318286562 1078 dbSNP
rs1218971863 1079 dbSNP
rs766324506 1091 dbSNP
rs769810426 1093 dbSNP
rs572200095 1094 dbSNP
rs750501557 1100 dbSNP
rs1274216684 1101 dbSNP
rs1215470857 1106 dbSNP
rs1215719742 1106 dbSNP
rs1236357511 1113 dbSNP
rs1439015675 1116 dbSNP
rs1333005679 1123 dbSNP
rs1409920779 1125 dbSNP
rs555403490 1126 dbSNP
rs533368124 1131 dbSNP
rs1395276007 1132 dbSNP
rs564653374 1144 dbSNP
rs541187097 1147 dbSNP
rs1030928726 1148 dbSNP
rs997906544 1150 dbSNP
rs899589122 1154 dbSNP
rs1268338583 1162 dbSNP
rs1039364246 1164 dbSNP
rs1377487760 1165 dbSNP
rs1226237374 1176 dbSNP
rs113080612 1178 dbSNP
rs1311638921 1178 dbSNP
rs34892399 1178 dbSNP
rs397969232 1178 dbSNP
rs1234522143 1181 dbSNP
rs1327671042 1181 dbSNP
rs1459512016 1183 dbSNP
rs941044586 1184 dbSNP
rs1393305694 1186 dbSNP
rs1482179540 1190 dbSNP
rs1170767729 1193 dbSNP
rs1181480489 1193 dbSNP
rs1476312086 1197 dbSNP
rs1411120377 1207 dbSNP
rs888348240 1211 dbSNP
rs1423034029 1220 dbSNP
rs1047043878 1222 dbSNP
rs929893299 1226 dbSNP
rs951328526 1257 dbSNP
rs572535313 1262 dbSNP
rs1447848328 1266 dbSNP
rs917067670 1268 dbSNP
rs1303800010 1272 dbSNP
rs1355638892 1278 dbSNP
rs74125570 1281 dbSNP
rs937406450 1286 dbSNP
rs762078062 1293 dbSNP
rs73027686 1305 dbSNP
rs1195922578 1322 dbSNP
rs978727680 1329 dbSNP
rs1252581413 1330 dbSNP
rs1006706373 1331 dbSNP
rs968713017 1331 dbSNP
rs1486748045 1338 dbSNP
rs1191828504 1339 dbSNP
rs1205575326 1378 dbSNP
rs1262542566 1383 dbSNP
rs576451064 1385 dbSNP
rs1309317228 1392 dbSNP
rs891052875 1394 dbSNP
rs1414417318 1397 dbSNP
rs1174606389 1399 dbSNP
rs1020481070 1404 dbSNP
rs556487674 1415 dbSNP
rs1050993880 1416 dbSNP
rs1348536787 1417 dbSNP
rs1416206740 1420 dbSNP
rs1296012464 1424 dbSNP
rs1325332968 1428 dbSNP
rs1430910333 1430 dbSNP
rs1305295867 1438 dbSNP
rs1271436333 1445 dbSNP
rs1365334333 1447 dbSNP
rs878966542 1453 dbSNP
rs955147263 1454 dbSNP
rs1218597644 1463 dbSNP
rs999603902 1468 dbSNP
rs1349849607 1476 dbSNP
rs539680214 1488 dbSNP
rs768839525 1489 dbSNP
rs1043366882 1500 dbSNP
rs946499755 1511 dbSNP
rs763375796 1512 dbSNP
rs1477967228 1519 dbSNP
rs1194851757 1523 dbSNP
rs1018061081 1530 dbSNP
rs145674243 1537 dbSNP
rs1156449453 1540 dbSNP
rs1418316007 1540 dbSNP
rs1005211881 1542 dbSNP
rs28613504 1546 dbSNP
rs1169173691 1547 dbSNP
rs16831744 1549 dbSNP
rs1319661830 1554 dbSNP
rs1396191009 1562 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.576 1.6e-3 0.319 6.4e-2 24 Click to see details
GSE28260 Renal cortex and medulla 0.722 2.7e-3 0.681 5.2e-3 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.278 9.4e-2 0.124 2.8e-1 24 Click to see details
GSE19536 Breast cancer 0.121 1.2e-1 0.212 1.7e-2 100 Click to see details
GSE42095 Differentiated embryonic stem cells 0.244 1.3e-1 0.217 1.6e-1 23 Click to see details
GSE19783 ER+ ER+ breast cancer 0.262 1.3e-1 0.084 3.6e-1 20 Click to see details
GSE17498 Multiple myeloma -0.179 1.3e-1 -0.087 3.0e-1 40 Click to see details
GSE21687 Ependynoma primary tumors -0.13 1.5e-1 -0.090 2.4e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.304 1.7e-1 -0.070 4.1e-1 12 Click to see details
GSE19783 ER- ER- breast cancer 0.072 2.6e-1 0.199 3.9e-2 79 Click to see details
GSE38226 Liver fibrosis 0.131 2.9e-1 0.009 4.8e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.083 3.5e-1 -0.207 1.6e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.052 3.9e-1 0.047 4.0e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.019 4.7e-1 -0.403 3.9e-2 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.019 4.7e-1 -0.403 3.9e-2 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.708 0.01 -0.736 0 11 Click to see details
KICH 0.473 0.01 0.369 0.03 25 Click to see details
CESC -0.998 0.02 -1.000 0.5 3 Click to see details
KIRC 0.199 0.05 0.074 0.27 68 Click to see details
STAD 0.287 0.06 0.441 0.01 32 Click to see details
COAD -0.604 0.06 -0.524 0.09 8 Click to see details
THCA 0.155 0.12 0.026 0.42 59 Click to see details
PAAD -0.646 0.18 -0.800 0.1 4 Click to see details
CHOL -0.254 0.25 -0.200 0.3 9 Click to see details
HNSC 0.102 0.26 0.074 0.32 42 Click to see details
UCEC -0.138 0.29 -0.256 0.15 19 Click to see details
PRAD -0.049 0.37 -0.099 0.25 50 Click to see details
BLCA -0.079 0.38 -0.110 0.33 18 Click to see details
PCPG 0.319 0.4 0.500 0.33 3 Click to see details
LIHC -0.038 0.4 -0.052 0.36 49 Click to see details
LUAD -0.07 0.41 -0.175 0.29 12 Click to see details
LUSC 0.031 0.43 -0.070 0.34 38 Click to see details
BRCA -0.017 0.44 -0.029 0.4 84 Click to see details
KIRP -0.017 0.46 -0.018 0.46 32 Click to see details
KIRP -0.017 0.46 -0.018 0.46 32 Click to see details
KIRP -0.017 0.46 -0.018 0.46 32 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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