miRTarBase - #MIRT441353


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pre-miRNA Information
pre-miRNA hsa-mir-4473   
Genomic Coordinates chr9: 20411148 - 20411238
Description Homo sapiens miR-4473 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4473
Sequence 57| CUAGUGCUCUCCGUUACAAGUA |78
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs987949614 1 dbSNP
rs1199578146 4 dbSNP
rs1261784605 4 dbSNP
rs950939079 6 dbSNP
rs573478506 9 dbSNP
rs182397728 12 dbSNP
rs963590806 17 dbSNP
rs1452942530 19 dbSNP
rs1016614368 20 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF75A   
Synonyms -
Description zinc finger protein 75a
Transcript NM_153028   
Expression
Putative miRNA Targets on ZNF75A
3'UTR of ZNF75A
(miRNA target sites are highlighted)		 
>ZNF75A|NM_153028|3'UTR
   1 AGAGAAGCTTGTCCAGTGTCCTCATTCTGAAGACATTCACCAAATGGAGCTTGGCACTAAAATTTATGTAAAAGAAAAAT
  81 CACAAACCTTGAAAAATTTTACATCAGAAAATGGGATAAACATACATTTCACAGAAAATAATCAAGACTTGCTCTGCAGC
 161 CACTCAGTAGTCTTCTGTGGTCACAGAAGTAAACATTGTTGGCTTTGTATTGATCTCTCCAGTCATTTTTGAACACATCC
 241 AATAGAAACATTGGCAGCATGGTCTTCCAAAACAAAAAGCAGTAACATGCATGTTTAATTGCATACCATTCTCTTCACAG
 321 TAGCAGGCTTACCAATTTCCATAGTCTCATGAGGCCGAAATGAATTACAATGTAAAGTGTTCCAGGAACCAAATTGGATT
 401 TTCTTTCTTTTGTCATTGGACACGGTTTGCAAAGTTGGACATCACTTGAGTTCCTTCTTAAACTTTTCGGCAACTTCTCT
 481 TGGATCCTGTTATCACAGTTTTTTACTGTGATGAAATCTTGTTAACCACCACTAGGGAATCTCCAGATGAACTATTAATG
 561 CACTGTCTTATGCCTCTCATTGGTGATGTTTGGAAAATAGAAGACATCTCTAATGGAATCATGGGGGAAACGGGTTGGAA
 641 TTTGTAGCCATGGAATATATATTAGATGTAAAGAATTTTCTGCAATAAAAGAAACTAGACTTGTTAAAAAAAAAAAAAAA
 721 AAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' augaacaUUGCCUC---UCGUGAUc 5'
                 ||:||||   :|||||| 
Target 5' ttcaccaAATGGAGCTTGGCACTAa 3'
 36 - 60 143.00 -14.60
2 
miRNA  3' auGAAC-AUUGCCUCUCGUGAUc 5'
            |||| ||||    | ||||| 
Target 5' atCTTGTTAAC---CACCACTAg 3'
 516 - 535 125.00 -11.10
3 
miRNA  3' auGAACAUU---GCCUCUCGUGAuc 5'
            :||| ||   :||| | ||||  
Target 5' ggTTTGCAAAGTTGGACATCACTtg 3'
 424 - 448 112.00 -7.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30153515 39 COSMIC
COSN30153248 106 COSMIC
COSN22070278 288 COSMIC
COSN32092257 352 COSMIC
COSN20575662 358 COSMIC
COSN24268217 431 COSMIC
COSN21007184 469 COSMIC
COSN7305703 737 COSMIC
COSN29338196 961 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1205251570 3 dbSNP
rs1394474590 8 dbSNP
rs776892442 12 dbSNP
rs1370913841 14 dbSNP
rs1383922156 16 dbSNP
rs772026118 19 dbSNP
rs1296115807 21 dbSNP
rs1448695770 22 dbSNP
rs762021359 28 dbSNP
rs765379003 33 dbSNP
rs1310963416 35 dbSNP
rs1432994143 36 dbSNP
rs1226106713 39 dbSNP
rs750802765 42 dbSNP
rs758741691 43 dbSNP
rs200502645 44 dbSNP
rs752075098 45 dbSNP
rs1461654820 47 dbSNP
rs1185187658 48 dbSNP
rs574352487 56 dbSNP
rs1019048646 63 dbSNP
rs889132168 66 dbSNP
rs186369703 67 dbSNP
rs1209336197 80 dbSNP
rs1485094851 87 dbSNP
rs564022250 89 dbSNP
rs1217512043 97 dbSNP
rs532664687 97 dbSNP
rs1314712130 106 dbSNP
rs191273608 109 dbSNP
rs1009853807 115 dbSNP
rs1455127227 120 dbSNP
rs559478171 122 dbSNP
rs1357107847 127 dbSNP
rs1024799896 133 dbSNP
rs1395803544 138 dbSNP
rs1439182797 146 dbSNP
rs1289468102 147 dbSNP
rs531997393 148 dbSNP
rs1343618323 151 dbSNP
rs1367328886 152 dbSNP
rs1224606312 158 dbSNP
rs1462344228 160 dbSNP
rs970932177 161 dbSNP
rs548257489 162 dbSNP
rs1186426697 163 dbSNP
rs568152867 169 dbSNP
rs927192229 170 dbSNP
rs1327178223 171 dbSNP
rs530953937 172 dbSNP
rs1187724441 173 dbSNP
rs958371498 174 dbSNP
rs1259834403 178 dbSNP
rs1033568748 183 dbSNP
rs1336763603 189 dbSNP
rs1270967326 193 dbSNP
rs550672144 196 dbSNP
rs1414431462 204 dbSNP
rs917035683 208 dbSNP
rs983769547 210 dbSNP
rs1468893781 212 dbSNP
rs1359935344 216 dbSNP
rs569936353 226 dbSNP
rs1288575586 232 dbSNP
rs1223650502 235 dbSNP
rs1441830052 237 dbSNP
rs1338504628 243 dbSNP
rs1163162797 244 dbSNP
rs908329352 245 dbSNP
rs761697439 250 dbSNP
rs538517841 251 dbSNP
rs1041918642 255 dbSNP
rs976875571 257 dbSNP
rs141236346 258 dbSNP
rs1250935828 259 dbSNP
rs933465020 260 dbSNP
rs1417921654 267 dbSNP
rs1051123374 276 dbSNP
rs1225142714 281 dbSNP
rs1305840176 286 dbSNP
rs1322140886 287 dbSNP
rs1296891883 288 dbSNP
rs1235325961 289 dbSNP
rs111551659 294 dbSNP
rs111655288 294 dbSNP
rs1324097686 302 dbSNP
rs1440691639 303 dbSNP
rs1050648464 304 dbSNP
rs1397641686 305 dbSNP
rs1008938309 306 dbSNP
rs1310109885 307 dbSNP
rs565876768 309 dbSNP
rs897938599 314 dbSNP
rs994000104 319 dbSNP
rs1392928063 332 dbSNP
rs936696124 333 dbSNP
rs1027714187 336 dbSNP
rs1358549998 337 dbSNP
rs1053789244 338 dbSNP
rs1230026889 339 dbSNP
rs1252318202 341 dbSNP
rs1287562063 342 dbSNP
rs767248958 343 dbSNP
rs1480239030 346 dbSNP
rs1274050531 349 dbSNP
rs1320906203 350 dbSNP
rs892579112 353 dbSNP
rs1009661161 357 dbSNP
rs534735446 358 dbSNP
rs767358152 369 dbSNP
rs1232803193 373 dbSNP
rs1025457510 380 dbSNP
rs1336732494 385 dbSNP
rs1309533460 390 dbSNP
rs554688604 392 dbSNP
rs906379084 393 dbSNP
rs1396359808 394 dbSNP
rs1180989462 395 dbSNP
rs775434751 406 dbSNP
rs1257685865 408 dbSNP
rs1002024778 417 dbSNP
rs1172625938 418 dbSNP
rs144128772 424 dbSNP
rs952606848 425 dbSNP
rs1179344003 428 dbSNP
rs1418253775 434 dbSNP
rs1258195526 436 dbSNP
rs966988258 444 dbSNP
rs151010994 446 dbSNP
rs1200108216 447 dbSNP
rs1351613731 451 dbSNP
rs1410907032 456 dbSNP
rs936176235 458 dbSNP
rs1170921937 462 dbSNP
rs556634859 464 dbSNP
rs114219696 469 dbSNP
rs183519629 470 dbSNP
rs922314633 473 dbSNP
rs1342348981 474 dbSNP
rs1418301650 483 dbSNP
rs933517185 489 dbSNP
rs986241837 490 dbSNP
rs1282380400 494 dbSNP
rs897845312 494 dbSNP
rs910843063 499 dbSNP
rs1186885118 505 dbSNP
rs1447626278 508 dbSNP
rs936916455 512 dbSNP
rs559551503 517 dbSNP
rs544354318 519 dbSNP
rs913905612 525 dbSNP
rs1235700048 527 dbSNP
rs1333277302 528 dbSNP
rs1339800404 531 dbSNP
rs1204006107 533 dbSNP
rs1315866687 535 dbSNP
rs1433814865 536 dbSNP
rs528648899 537 dbSNP
rs945342502 539 dbSNP
rs1005835928 547 dbSNP
rs1034127723 553 dbSNP
rs894425169 559 dbSNP
rs1046505604 564 dbSNP
rs1191316479 570 dbSNP
rs1243918714 570 dbSNP
rs750061497 581 dbSNP
rs541987975 584 dbSNP
rs1002077168 586 dbSNP
rs1054959483 589 dbSNP
rs371994832 589 dbSNP
rs1215662370 594 dbSNP
rs977081824 598 dbSNP
rs1191045310 604 dbSNP
rs1227245127 607 dbSNP
rs1371228490 608 dbSNP
rs1033210689 609 dbSNP
rs1349080678 622 dbSNP
rs113750379 625 dbSNP
rs185998147 628 dbSNP
rs1421763422 632 dbSNP
rs550964666 633 dbSNP
rs1404558577 651 dbSNP
rs910713069 654 dbSNP
rs944831160 664 dbSNP
rs1195717527 667 dbSNP
rs1453036967 674 dbSNP
rs976332773 683 dbSNP
rs919473737 685 dbSNP
rs1349838554 686 dbSNP
rs929330630 687 dbSNP
rs1333646399 688 dbSNP
rs1203865391 689 dbSNP
rs1347948450 692 dbSNP
rs1015904249 693 dbSNP
rs1345846626 695 dbSNP
rs1305256104 698 dbSNP
rs1231624602 700 dbSNP
rs1366656835 701 dbSNP
rs1279865203 704 dbSNP
rs1444327318 710 dbSNP
rs1435808222 716 dbSNP
rs1307311037 725 dbSNP
rs755746879 730 dbSNP
rs1299645722 733 dbSNP
rs1362781274 736 dbSNP
rs961082725 738 dbSNP
rs191163757 742 dbSNP
rs532483166 744 dbSNP
rs1424933017 758 dbSNP
rs150136289 767 dbSNP
rs1471344898 769 dbSNP
rs1055106554 770 dbSNP
rs894331706 775 dbSNP
rs1198350698 783 dbSNP
rs986295827 792 dbSNP
rs564010853 794 dbSNP
rs529586457 803 dbSNP
rs1464956164 806 dbSNP
rs989762099 812 dbSNP
rs914127787 821 dbSNP
rs987527951 828 dbSNP
rs1370889117 845 dbSNP
rs764176204 847 dbSNP
rs1287722104 851 dbSNP
rs549940271 853 dbSNP
rs1415248669 858 dbSNP
rs1356191502 862 dbSNP
rs1314775068 863 dbSNP
rs1464761241 873 dbSNP
rs945420700 876 dbSNP
rs1358846083 877 dbSNP
rs1246666462 878 dbSNP
rs1046828216 881 dbSNP
rs998968930 888 dbSNP
rs1199978557 893 dbSNP
rs1287578506 897 dbSNP
rs534825631 899 dbSNP
rs1475790123 901 dbSNP
rs928070758 904 dbSNP
rs1259038834 905 dbSNP
rs938087994 912 dbSNP
rs867055955 913 dbSNP
rs1032663273 920 dbSNP
rs1055176536 921 dbSNP
rs1242397387 928 dbSNP
rs888300332 932 dbSNP
rs1314913531 936 dbSNP
rs1042079387 937 dbSNP
rs1267194284 939 dbSNP
rs1233846391 940 dbSNP
rs1005767056 945 dbSNP
rs1291330169 951 dbSNP
rs138605857 952 dbSNP
rs897042946 953 dbSNP
rs547904343 955 dbSNP
rs1029275666 963 dbSNP
rs141199481 964 dbSNP
rs1320275575 972 dbSNP
rs183331688 979 dbSNP
rs1462260385 980 dbSNP
rs1420685399 981 dbSNP
rs1163224344 982 dbSNP
rs950977760 983 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augaacauugccucUCGUGAUc 5'
                        :|||||| 
Target 5' ------------uuGGCACUAa 3'
 		1 - 10
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000574298.1 | 3UTR | UUGGCACUAAAAUUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
53 hsa-miR-4473 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT193963 GLCE glucuronic acid epimerase 2 2
MIRT232832 NUPL1 nucleoporin 58 2 2
MIRT306237 ZMAT3 zinc finger matrin-type 3 2 4
MIRT441353 ZNF75A zinc finger protein 75a 2 2
MIRT443665 FLT1 fms related tyrosine kinase 1 2 2
MIRT448553 RAP1A RAP1A, member of RAS oncogene family 2 2
MIRT448625 OSBPL8 oxysterol binding protein like 8 2 2
MIRT449138 UQCRB ubiquinol-cytochrome c reductase binding protein 2 2
MIRT462942 ZNF800 zinc finger protein 800 2 12
MIRT463962 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT466315 THRA thyroid hormone receptor, alpha 2 2
MIRT493504 IL6ST interleukin 6 signal transducer 2 2
MIRT502727 CLIP1 CAP-Gly domain containing linker protein 1 2 8
MIRT503464 ZNF154 zinc finger protein 154 2 6
MIRT506738 LMLN leishmanolysin like peptidase 2 4
MIRT507282 FEM1B fem-1 homolog B 2 2
MIRT510711 SPG20 spartin 2 6
MIRT524495 CEP170 centrosomal protein 170 2 4
MIRT529425 MALT1 MALT1 paracaspase 2 2
MIRT533482 TRIM71 tripartite motif containing 71 2 2
MIRT533715 TMEM30A transmembrane protein 30A 2 2
MIRT534115 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT534473 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536519 KCTD10 potassium channel tetramerization domain containing 10 2 2
MIRT537263 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537597 ESRP2 epithelial splicing regulatory protein 2 2 2
MIRT537918 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT538074 DIAPH2 diaphanous related formin 2 2 2
MIRT538707 CAPRIN2 caprin family member 2 2 4
MIRT546187 TPD52 tumor protein D52 2 4
MIRT546942 SFTPA1 surfactant protein A1 2 2
MIRT549590 TMEM101 transmembrane protein 101 2 2
MIRT551686 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT551948 RNF157 ring finger protein 157 2 2
MIRT553176 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT555074 PURG purine rich element binding protein G 2 2
MIRT556214 MB21D2 Mab-21 domain containing 2 2 2
MIRT556476 LIPA lipase A, lysosomal acid type 2 2
MIRT556683 KLHL28 kelch like family member 28 2 2
MIRT556863 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT558402 DEPDC1 DEP domain containing 1 2 2
MIRT558716 CLCN3 chloride voltage-gated channel 3 2 2
MIRT559512 ARHGEF26 Rho guanine nucleotide exchange factor 26 2 2
MIRT566872 LRP12 LDL receptor related protein 12 2 2
MIRT567038 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT574515 PRC1 protein regulator of cytokinesis 1 2 2
MIRT642220 RABAC1 Rab acceptor 1 2 2
MIRT651915 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT654128 RPL14 ribosomal protein L14 2 2
MIRT654344 RBM27 RNA binding motif protein 27 2 2
MIRT669250 C4orf36 chromosome 4 open reading frame 36 2 2
MIRT683176 UBL3 ubiquitin like 3 2 2
MIRT718768 ABHD15 abhydrolase domain containing 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4473 Plx-4720 24180719 NSC757438 resistant High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-4473 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-4473 Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-4473 Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-4473 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-4473 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4473 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4473 Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil resistant tissue (myasthenia gravis)

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