pre-miRNA Information | |
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pre-miRNA | hsa-mir-2110 |
Genomic Coordinates | chr10: 114174105 - 114174179 |
Synonyms | hsa-mir-2110, MIR2110 |
Description | Homo sapiens miR-2110 stem-loop |
Comment | Zhu et al. incorrectly referred to this sequence as mir-1309 in . This sequence is unrelated to MIR1309 in plants. |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | |||||||||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-2110 | ||||||||||||||||||||||||||||||||||||||||||
Sequence | 8| UUGGGGAAACGGCCGCUGAGUG |29 | ||||||||||||||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||||||||||||||
Experiments | 454 | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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miRNAs in Extracellular Vesicles |
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Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | NCEH1 | ||||||||||||||||||||
Synonyms | AADACL1, NCEH | ||||||||||||||||||||
Description | neutral cholesterol ester hydrolase 1 | ||||||||||||||||||||
Transcript | NM_001146276 | ||||||||||||||||||||
Other Transcripts | NM_001146277 , NM_001146278 , NM_020792 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on NCEH1 | |||||||||||||||||||||
3'UTR of NCEH1 (miRNA target sites are highlighted) |
>NCEH1|NM_001146276|3'UTR 1 AGGAGCAAAACTTCCAGAAGCCTCGAGCCCCTCTTGACCTCCTACACCTGCTTTGGAAAGACATGCACTTTTTAGTTGAC 81 TAATTCTTCCTCCCATTCCCCTCTACTTGCGAGTTATGGAATTTCTATTCCATAACTGAAGTCTTTATGATAACCTAATT 161 TTTAAAAATGAATTTGACTAACTTAAGTGCAAAACATGTAAATTTGGTTCCCAGAGTGGGCCAATCTCTCTGTTCTTGTT 241 ATCTTAGCCAACTATACTGATACCTACAGCTACAGAAAGCAGGACTAGGAACTGGAAATAACTTTGGGTCCTGCCTTCAT 321 TAGGACGTTCTTTTTAGAAGCAGTTCTTCCAGCTCTGGATCATAGAGTGACCTTTAATAAGTTAAAAAAACGAGGACTCC 401 TTAATTCTGCTAGAGTTAACCTTGAGTTCAGAGCAGTATTAAATGCGTGCACTTTCAGGTCAGTACTGGGGACCAAGTAC 481 CCTCTGGTCTTTTGTGAATGGATGGTTTTGTTTCCTATGGGAATTTTGGCAAAGGTTTTCTGGAAAGAACAAGTTTCTCA 561 AAGGACTTTCTTCCTCTAGAATGTTCATTTTATGAGATCGCTATCTGTAAGTCCAGTTGGATTACAGGAATACTTGAAAG 641 TTACTTTCTACCACTATTAGAAAATATGAAGTCGCATGCACTGGATATCTATATATCATTAGGTTTTTGTTGTGTTTTTG 721 GTTATGCTGTCCCCCTTCTCCTTGGGGAGATATTTGGGAGCAAACTTATTTAGATTTAGAGTAAACTTTTCATTATAGAG 801 CAAGTAAAAACAGACAAATGAAACAACCTAGTGTTTCACATAAAAATACTTCTGACATAAAGTACCAAGAGCAGTGTGAA 881 TATACTTGGCATAGTCAAAAAAGAAAATACATTTAATATTAGTTCAAAATTGTTAAAAATACCTTTAGAAGGTCTAGTCT 961 ATTATTGAAAACTCAATTTTTTCACTTATATGGCTTTAAAATGGAGCTATTTTGCTACAATATAATGTATTGTTTATTTT 1041 TTTAAGTTATTTAATGTTAATATACATAGCTAGACTTAAGGTTTTTCAGAAAGATGTCCATAATAAATATTAAAAACAAT 1121 GGTATTTTTTAAAAAACTGCCTTAGGGTTTTAAAACCTTCCCTACAGTTATAACCACGTGTAATTTTGTGGAAATGATAT 1201 AACAGCTATTAATACTACTATAACATAGGCATAAATATTTTCGTGTTTATATGCATATACAAGTTAAAATAATTAGAAAC 1281 TATGACTGCGCCTAGTAAAGTCATCTAGGTTTATAGTTCAGTAGCTTAGGCAAGGCACACACTGCTCATCTCCGCTTTTT 1361 AGGGTCAGAGGAACACAAGCTCATGTTCTGAGTGAAGGGCGTACACTGGCACCTGGTGTTGCCTAGATCCCCCATCTCCT 1441 CCTTCCAGCCAGGTCTGGAAGTTTCAACAGCCCAAGCTTAACTTCATGTAAAGTCTTCACTGCCAGTGGGAACATCTTTG 1521 ACACAACAAGACACTCCAATTGTGATTTGAGTTGAGGATCTCTGCCTGCCTTCCTGCCGTCCTTCCTTCTTCCCCGATCC 1601 ATGCTACTTTTAGGGGCTGCGGAGAGCAGCAGCAGAGCTGAGTAATGATACAGGGCACCACGGAGAGAAAGTAGAACCAT 1681 TTCACTCCTGGGAAGATGGGGTATTTCCCACTTCCAGCAACGAAATAACAAATGAAAAGTTGCATACTTATTGATGTATT 1761 GTATGAGCCAGTAGCATTTTATGTACAAAACAGAAGTCAATGCAACAGTATGTATGTGTGCCTGTGTGTGTATAAAAATA 1841 ACCATTGAAGCTAACTTGCTAATGTACTTAGGCAAGCCACTTCCCATCTCTGGGCCTCGTCTTTCCTCCCTCTAAAATCA 1921 AAGAGCTGAATTATGTGATCCTTGAGGTCTCTTCCACTTATAATACCAACTGTCTTGTCAGACTGGCAAATTATATTGGC 2001 CTCTCCTTATGTGGTGGTTTTTTTGGTAGGTCATAGTTCCTTATACACAGACACCTGCATCATCGAAGGTCTTTTTTTCC 2081 TAAAAAAAAAAAATGGGATTTTAGTTCTTATTCTGTGATAACTATCCTCCTCATATAATACTATTCTTTTTGACACCATT 2161 TGAAGGAACCAATATTTGGACCTTATTTTGAGGTTGTCTGTCTCGAAGAAAAAGAAAATAAAATGTATAGGCAGGGTTCC 2241 TTCAATTGGCATTTTCCCCAGAATTGTGAGCCAAAGCCTATAGTAATTGCAGACAGCAAATGATTCCGGATCTCTAAAAG 2321 GCTCTCTCAGATGAAAAGGGAGTAAAGGAAAAAAGAGGTCAACCACTGTTTCTGATAATGTACTTGAGTTTCATTGTTCT 2401 TTTAGTTTGTATTCTTATAAAAAATGTTTACACTCTGCAGATTGATTTTTTTTTTTTAGTACTGTGGCTTTCTTTTCCTA 2481 TTTTATGAAAAAAATGATAATCTTTTTGTAAAATTGTCTGTGAAATATAAACATTAATATATAAAGAAAAACCTTGAAGT 2561 GCTGTATAGTGAAGTATAAATTAATGTTTTATTGATTTGTGAAGAATTTAAGACTATTATATAATTATCTTGGTGGATCT 2641 ATTTTATGCATGACCTTTTAACCTTTGACTTTGCTTATTTCCCACTACGAAGGGGAAGGTAGATTTTATGAATGATTTTA 2721 ATAGCAAATATATTTTATAAAGTGAAAATCCAGTGTGGAGGTAGCAAAGCATCTATCTATTCTGAATCATGTTTGGAAAT 2801 AAAATTGCTCCATCTGGGAATGTGCTTTCAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | BC-3 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine
PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796039 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-3 / 4-Thiouridine |
Location of target site | ENST00000475381.1 | 3UTR | UUGGCAUUUUCCCCAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM796040 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-3 / 4-Thiouridine |
Location of target site | ENST00000475381.1 | 3UTR | UUGGCAUUUUCCCCAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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96 hsa-miR-2110 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT035757 | BRD4 | bromodomain containing 4 | 1 | 1 | ||||||||
MIRT035758 | NCOR2 | nuclear receptor corepressor 2 | 1 | 1 | ||||||||
MIRT035759 | FASN | fatty acid synthase | 1 | 1 | ||||||||
MIRT035760 | C10orf118 | coiled-coil domain containing 186 | 1 | 1 | ||||||||
MIRT055403 | SHOC2 | SHOC2, leucine rich repeat scaffold protein | 2 | 6 | ||||||||
MIRT066205 | MARCH9 | membrane associated ring-CH-type finger 9 | 2 | 2 | ||||||||
MIRT079365 | CCDC137 | coiled-coil domain containing 137 | 2 | 2 | ||||||||
MIRT081180 | MIDN | midnolin | 2 | 4 | ||||||||
MIRT082397 | HNRNPUL1 | heterogeneous nuclear ribonucleoprotein U like 1 | 2 | 4 | ||||||||
MIRT089000 | BCL11A | B-cell CLL/lymphoma 11A | 2 | 2 | ||||||||
MIRT133706 | SKI | SKI proto-oncogene | 2 | 4 | ||||||||
MIRT160053 | TET3 | tet methylcytosine dioxygenase 3 | 2 | 4 | ||||||||
MIRT180853 | RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 2 | 2 | ||||||||
MIRT263243 | SGPL1 | sphingosine-1-phosphate lyase 1 | 2 | 2 | ||||||||
MIRT285532 | CDT1 | chromatin licensing and DNA replication factor 1 | 2 | 2 | ||||||||
MIRT317152 | E2F3 | E2F transcription factor 3 | 2 | 4 | ||||||||
MIRT321166 | EIF4H | eukaryotic translation initiation factor 4H | 2 | 2 | ||||||||
MIRT441482 | NCEH1 | neutral cholesterol ester hydrolase 1 | 2 | 2 | ||||||||
MIRT443884 | CNKSR3 | CNKSR family member 3 | 2 | 2 | ||||||||
MIRT445877 | WBP1L | WW domain binding protein 1 like | 2 | 2 | ||||||||
MIRT446195 | GTPBP4 | GTP binding protein 4 | 2 | 2 | ||||||||
MIRT449308 | MRO | maestro | 2 | 2 | ||||||||
MIRT450301 | DRAXIN | dorsal inhibitory axon guidance protein | 2 | 2 | ||||||||
MIRT450512 | EMX1 | empty spiracles homeobox 1 | 2 | 2 | ||||||||
MIRT451534 | CIAPIN1 | cytokine induced apoptosis inhibitor 1 | 2 | 2 | ||||||||
MIRT451820 | ALDH3B1 | aldehyde dehydrogenase 3 family member B1 | 2 | 2 | ||||||||
MIRT452239 | TRAM1 | translocation associated membrane protein 1 | 2 | 2 | ||||||||
MIRT454207 | HLA-A | major histocompatibility complex, class I, A | 2 | 2 | ||||||||
MIRT455447 | EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 2 | 2 | ||||||||
MIRT456496 | PFKFB2 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 | 2 | 2 | ||||||||
MIRT457656 | SERINC1 | serine incorporator 1 | 2 | 2 | ||||||||
MIRT459819 | TPP1 | tripeptidyl peptidase 1 | 2 | 2 | ||||||||
MIRT460556 | FEM1A | fem-1 homolog A | 2 | 2 | ||||||||
MIRT462561 | STS | steroid sulfatase | 2 | 2 | ||||||||
MIRT462986 | ZNF740 | zinc finger protein 740 | 2 | 2 | ||||||||
MIRT464671 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | 2 | 2 | ||||||||
MIRT465432 | TP53 | tumor protein p53 | 2 | 2 | ||||||||
MIRT465934 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | 2 | 2 | ||||||||
MIRT466015 | TMEM189 | transmembrane protein 189 | 2 | 2 | ||||||||
MIRT468122 | SH3PXD2A | SH3 and PX domains 2A | 2 | 2 | ||||||||
MIRT469652 | RAC1 | Rac family small GTPase 1 | 2 | 2 | ||||||||
MIRT469980 | PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2 | 2 | ||||||||
MIRT473531 | MAX | MYC associated factor X | 2 | 2 | ||||||||
MIRT473596 | MARK2 | microtubule affinity regulating kinase 2 | 2 | 2 | ||||||||
MIRT473652 | MARCKSL1 | MARCKS like 1 | 2 | 2 | ||||||||
MIRT474219 | LCOR | ligand dependent nuclear receptor corepressor | 2 | 4 | ||||||||
MIRT474771 | KIAA0895L | KIAA0895 like | 2 | 2 | ||||||||
MIRT479312 | VPS72 | vacuolar protein sorting 72 homolog | 2 | 2 | ||||||||
MIRT481121 | AZIN1 | antizyme inhibitor 1 | 2 | 4 | ||||||||
MIRT481682 | AR | androgen receptor | 2 | 2 | ||||||||
MIRT482381 | AEN | apoptosis enhancing nuclease | 2 | 2 | ||||||||
MIRT483833 | UNC5B | unc-5 netrin receptor B | 2 | 4 | ||||||||
MIRT484693 | RNF11 | ring finger protein 11 | 2 | 2 | ||||||||
MIRT485238 | POGZ | pogo transposable element derived with ZNF domain | 2 | 2 | ||||||||
MIRT488748 | FXYD1 | FXYD domain containing ion transport regulator 1 | 2 | 2 | ||||||||
MIRT489147 | MRPL12 | mitochondrial ribosomal protein L12 | 2 | 4 | ||||||||
MIRT489518 | MRE11A | MRE11 homolog, double strand break repair nuclease | 2 | 8 | ||||||||
MIRT498908 | SRCAP | Snf2 related CREBBP activator protein | 2 | 2 | ||||||||
MIRT506426 | NAGK | N-acetylglucosamine kinase | 2 | 6 | ||||||||
MIRT506640 | MAPK1 | mitogen-activated protein kinase 1 | 2 | 4 | ||||||||
MIRT507332 | FAM168A | family with sequence similarity 168 member A | 2 | 2 | ||||||||
MIRT513099 | DYNAP | dynactin associated protein | 2 | 2 | ||||||||
MIRT513514 | YIPF4 | Yip1 domain family member 4 | 2 | 6 | ||||||||
MIRT521800 | POM121C | POM121 transmembrane nucleoporin C | 2 | 2 | ||||||||
MIRT525078 | FRK | fyn related Src family tyrosine kinase | 2 | 2 | ||||||||
MIRT530927 | SCIN | scinderin | 2 | 2 | ||||||||
MIRT533498 | TRIM71 | tripartite motif containing 71 | 2 | 2 | ||||||||
MIRT536787 | HNRNPD | heterogeneous nuclear ribonucleoprotein D | 2 | 2 | ||||||||
MIRT544554 | CSNK2A1 | casein kinase 2 alpha 1 | 2 | 2 | ||||||||
MIRT552977 | VAT1 | vesicle amine transport 1 | 2 | 2 | ||||||||
MIRT557358 | HAND1 | heart and neural crest derivatives expressed 1 | 2 | 2 | ||||||||
MIRT560401 | TMEM69 | transmembrane protein 69 | 2 | 2 | ||||||||
MIRT565498 | SP1 | Sp1 transcription factor | 2 | 2 | ||||||||
MIRT568962 | CACNA1C | calcium voltage-gated channel subunit alpha1 C | 2 | 2 | ||||||||
MIRT569031 | IL21R | interleukin 21 receptor | 2 | 2 | ||||||||
MIRT573224 | TRIM21 | tripartite motif containing 21 | 2 | 2 | ||||||||
MIRT574312 | ZNF703 | zinc finger protein 703 | 2 | 2 | ||||||||
MIRT620395 | MYO1H | myosin IH | 2 | 2 | ||||||||
MIRT620936 | OSMR | oncostatin M receptor | 2 | 2 | ||||||||
MIRT638166 | TMED4 | transmembrane p24 trafficking protein 4 | 2 | 2 | ||||||||
MIRT647743 | SAMD9L | sterile alpha motif domain containing 9 like | 2 | 2 | ||||||||
MIRT649991 | MSI1 | musashi RNA binding protein 1 | 2 | 2 | ||||||||
MIRT669203 | CBX8 | chromobox 8 | 2 | 2 | ||||||||
MIRT684546 | ZNF708 | zinc finger protein 708 | 2 | 2 | ||||||||
MIRT685837 | ANGEL1 | angel homolog 1 | 2 | 2 | ||||||||
MIRT688547 | DCAF16 | DDB1 and CUL4 associated factor 16 | 2 | 2 | ||||||||
MIRT693252 | HBS1L | HBS1 like translational GTPase | 2 | 2 | ||||||||
MIRT701970 | MIER3 | MIER family member 3 | 2 | 2 | ||||||||
MIRT706385 | MC2R | melanocortin 2 receptor | 2 | 2 | ||||||||
MIRT707484 | UGT2B4 | UDP glucuronosyltransferase family 2 member B4 | 2 | 2 | ||||||||
MIRT711882 | INSIG2 | insulin induced gene 2 | 2 | 2 | ||||||||
MIRT716906 | CACNB2 | calcium voltage-gated channel auxiliary subunit beta 2 | 2 | 2 | ||||||||
MIRT717638 | HLX | H2.0 like homeobox | 2 | 2 | ||||||||
MIRT719058 | ZNF281 | zinc finger protein 281 | 2 | 2 | ||||||||
MIRT723754 | NKIRAS2 | NFKB inhibitor interacting Ras like 2 | 2 | 2 | ||||||||
MIRT725479 | GPR26 | G protein-coupled receptor 26 | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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