miRTarBase - #MIRT441622


—
pre-miRNA Information
pre-miRNA hsa-mir-6768   
Genomic Coordinates chr16: 2463967 - 2464038
Description Homo sapiens miR-6768 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6768-3p
Sequence 45| CAAAGGCCACAUUCUCCUGUGCAC |68
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN28846463 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372529217 1 dbSNP
rs375499936 3 dbSNP
rs754371523 6 dbSNP
rs757893316 7 dbSNP
rs1234310587 11 dbSNP
rs369572179 12 dbSNP
rs746522005 14 dbSNP
rs768134371 15 dbSNP
rs372852875 16 dbSNP
rs572852254 17 dbSNP
rs769601549 18 dbSNP
rs773041368 20 dbSNP
rs762865317 23 dbSNP
rs770921850 24 dbSNP
Putative Targets

Gene Information
Gene Symbol ROCK1   
Synonyms P160ROCK, ROCK-I
Description Rho associated coiled-coil containing protein kinase 1
Transcript NM_005406   
Expression
Putative miRNA Targets on ROCK1
3'UTR of ROCK1
(miRNA target sites are highlighted)		 
>ROCK1|NM_005406|3'UTR
   1 CCATGTGACTGAGTGCCCTGTGGAATCGTGTGGGATGCTACCTGATAAACCAGGCTTCTTTAACCATGCAGAGCAGACAG
  81 GCTGTTTCTTTGACACAAATATCACAGGCTTCAGGGTTAAGATTGCTGTTTTTCTGTCCTTGCTTTGGCACAACACACTG
 161 AGGGTTTTTTTTATTGCGGGTTTGCCTACAGGTAGATTAGATTAATTATTACTATGTAATGCAAGTACAGTTGGGGGAAA
 241 GCTTAGGTAGATATATTTTTTTTAAAAGGTGCTGCCTTTTTGGATTTATAAGAAAATGCCTGTCAGTCGTGATAGAACAG
 321 AGTTTTCCTCATATGAGTAAGAGGAAGGGACTTTCACTTTCAAGTGGAACAGCCATCACTATCAAGATCAGCTCATGGAA
 401 GGAGTAAAGAAAATATCTCAAAATGAGACAAACTGAAGTTTTGTTTTTTTTTTAATGACTTAAGTTTTTGTGCTCTTGCA
 481 AGACTATACAAAACTATTTTAAGAAAGCAGTGATATCACTTGAACTTCAGTGCCCTCACTGTAGAATTTAAAAGCCTTAC
 561 TGTTGATTGCCCATGTTGGACTTGATGGAGAAATTAAATATCTTTCATTATGCTTTACAAAATACTGTATATGTTTCAGC
 641 AAGTTTGGGGAATGGGAGAGGACAAAAAAAAGTTACATTTAATCTATGCATTTTTGCCAAGCCATATTGAGTTATTTTAC
 721 TACTAGAGACATTAGGAAACTAACTGTACAAAAGAACCAAGTTTAAAAGCATTTTGTGGGGTACATCATTTCTATAATTG
 801 TATAATGTATTTCTTTGTGGTTTTAAATGATAAAGACATTAAGTTAACAAACATATAAGAAATGTATGCACTGTTTGAAA
 881 TGTAAATTATTCTTAGAACACTTTCAATGGGGGTTGCATTGTCCTTTTAGTGCCTTAATTTGAGATAATTATTTTACTGC
 961 CATGAGTAAGTATAGAAATTTCAAAAAATGTATTTTCAAAAAATTATGTGTGTCAGTGAGTTTTTCATTGATAATTGGTT
1041 TAATTTAAAATATTTAGAGGTTTGTTGGACTTTCATAAATTGAGTACAATCTTTGCATCAAACTACCTGCTACAATAATG
1121 ACTTTATAAAACTGCAAAAAATGTAGAAGGTTGCACCAACATAAAAAGGAAATATGGCAATACATCCATGATGTTTTCCA
1201 GTTAACATAGGAATTACCAGATAAATACTGTTAAACTCTTGTCCAGTAACAAGAGTTGATTCATATGGACAGTATGATTT
1281 ATTGTTTATTTTTTTAACCAAATACCTCCTCAGTAATTTATAATGGCTTTGCAGTAATGTGTATCAGATAAGAAGCACTG
1361 GAAAACCGATCGTCTCTAGGATGATATGCATGTTTCAAGTGGTATTGAAAGCCGCACTGATGGATATGTAATAATAAACA
1441 TATCTGTTATTAATATACTAATGACTCTGTGCTCATTTAATGAGAAATAAAAGTAATTTATGGATGGGTATCTTTAATTT
1521 TTACTGCAATGTGTTTTCTCATGGCTGAAATGAATGGAAAACATACTTCAAATTAGTCTCTGATTGTATATAAATGTTTG
1601 TGAAATTCCATGGTTAGATTAAAGTGTATTTTTAAAAGATAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' caCGUGUCCUCUUAC-ACCGGAAAc 5'
            |||||  | | ||  ||::||| 
Target 5' tgGCACAACACACTGAGGGTTTTTt 3'
 146 - 170 130.00 -10.10
2 
miRNA  3' caCGUGUCCUCUUACACCGGAAAc 5'
            | ::| |||:| | || |||| 
Target 5' atGAGTAAGAGGAAG-GGACTTTc 3'
 333 - 355 129.00 -8.60
3 
miRNA  3' cacGUGUCCUCUUAC---ACCGGAAAc 5'
             ||  ||:|: ||   || ||||| 
Target 5' tttCAATGGGGGTTGCATTGTCCTTTt 3'
 902 - 928 129.00 -10.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31496985 3 COSMIC
COSN31556722 5 COSMIC
COSN23018940 11 COSMIC
COSN30184633 44 COSMIC
COSN30449925 53 COSMIC
COSN30609347 109 COSMIC
COSN30139214 121 COSMIC
COSN30164144 125 COSMIC
COSN30164150 126 COSMIC
COSN8604401 163 COSMIC
COSN30133879 164 COSMIC
COSN31536389 164 COSMIC
COSN30580555 165 COSMIC
COSN31588935 177 COSMIC
COSN30122086 208 COSMIC
COSN31544228 285 COSMIC
COSN32155477 419 COSMIC
COSN20093412 427 COSMIC
COSN31482568 443 COSMIC
COSN31520335 443 COSMIC
COSN26603506 525 COSMIC
COSN30172939 558 COSMIC
COSN31522343 655 COSMIC
COSN28746177 690 COSMIC
COSN30109949 695 COSMIC
COSN30109960 696 COSMIC
COSN31595992 888 COSMIC
COSN28585750 1015 COSMIC
COSN16320551 1160 COSMIC
COSN25392086 1279 COSMIC
COSN31571931 1285 COSMIC
COSN20578318 1345 COSMIC
COSN9327207 1368 COSMIC
COSN31484173 1371 COSMIC
COSN26568479 1465 COSMIC
COSN26556628 1472 COSMIC
COSN26567814 1473 COSMIC
COSN26567351 1508 COSMIC
COSN26550287 1522 COSMIC
COSN1732611 1626 COSMIC
COSN28580686 1743 COSMIC
COSN19758776 1815 COSMIC
COSN23348485 1831 COSMIC
COSN19339169 1843 COSMIC
COSN16780658 1986 COSMIC
COSN9676334 1988 COSMIC
COSN26628720 2331 COSMIC
COSN22301941 2377 COSMIC
COSN17458340 2553 COSMIC
COSN17455068 2564 COSMIC
COSN24515313 2593 COSMIC
COSN21157664 2727 COSMIC
COSN24051399 3331 COSMIC
COSN7460550 3511 COSMIC
COSN28590811 4408 COSMIC
COSN31929377 4416 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763503847 1 dbSNP
rs925279691 1 dbSNP
rs978238956 2 dbSNP
rs773868393 3 dbSNP
rs779232123 3 dbSNP
rs1251075643 4 dbSNP
rs769211120 4 dbSNP
rs1490443830 6 dbSNP
rs1201383946 7 dbSNP
rs1266541499 8 dbSNP
rs967178535 9 dbSNP
rs1201128187 10 dbSNP
rs763630234 11 dbSNP
rs749655470 15 dbSNP
rs533340316 17 dbSNP
rs1045148 18 dbSNP
rs564509585 25 dbSNP
rs551088769 27 dbSNP
rs780916070 28 dbSNP
rs756659907 30 dbSNP
rs751083485 32 dbSNP
rs763931559 33 dbSNP
rs1436604802 34 dbSNP
rs1197681622 35 dbSNP
rs758391850 37 dbSNP
rs752469961 38 dbSNP
rs1436920663 50 dbSNP
rs1366775533 51 dbSNP
rs1437584928 52 dbSNP
rs200076625 57 dbSNP
rs770093483 66 dbSNP
rs1345309654 73 dbSNP
rs201895102 74 dbSNP
rs1001207111 75 dbSNP
rs1034226827 75 dbSNP
rs898864390 76 dbSNP
rs1015920194 77 dbSNP
rs1360010193 78 dbSNP
rs373823763 81 dbSNP
rs1427947189 88 dbSNP
rs1173502759 105 dbSNP
rs1488044919 108 dbSNP
rs1475263535 115 dbSNP
rs1264204685 116 dbSNP
rs1426776171 124 dbSNP
rs1188059974 131 dbSNP
rs1388742965 137 dbSNP
rs1004666373 142 dbSNP
rs1162227042 150 dbSNP
rs1365327549 152 dbSNP
rs561818965 170 dbSNP
rs886161810 172 dbSNP
rs1051958304 173 dbSNP
rs200547604 173 dbSNP
rs577498957 175 dbSNP
rs933445876 177 dbSNP
rs1382895887 178 dbSNP
rs1248011332 183 dbSNP
rs1312904672 190 dbSNP
rs900772116 191 dbSNP
rs1216280679 196 dbSNP
rs1262688326 199 dbSNP
rs1039296685 203 dbSNP
rs1440601764 212 dbSNP
rs1280707015 215 dbSNP
rs1243752272 219 dbSNP
rs371186721 221 dbSNP
rs781326139 223 dbSNP
rs757760998 224 dbSNP
rs1295132682 229 dbSNP
rs1420027763 230 dbSNP
rs925309143 242 dbSNP
rs1230811585 253 dbSNP
rs1366269667 254 dbSNP
rs1302328643 256 dbSNP
rs978484607 257 dbSNP
rs945494299 259 dbSNP
rs917971410 263 dbSNP
rs1335398369 264 dbSNP
rs1378407766 268 dbSNP
rs1224291195 269 dbSNP
rs992675454 275 dbSNP
rs1314915071 276 dbSNP
rs1429681999 283 dbSNP
rs529418855 288 dbSNP
rs959825563 288 dbSNP
rs1034174684 296 dbSNP
rs980053627 299 dbSNP
rs963279332 300 dbSNP
rs542019015 305 dbSNP
rs1004934588 309 dbSNP
rs1157948620 309 dbSNP
rs1429599385 312 dbSNP
rs886195402 315 dbSNP
rs1331566582 316 dbSNP
rs1358101872 327 dbSNP
rs1030460953 329 dbSNP
rs1180752372 339 dbSNP
rs1471493007 347 dbSNP
rs573020653 359 dbSNP
rs1210646278 361 dbSNP
rs1325870956 363 dbSNP
rs1482694637 363 dbSNP
rs997269072 366 dbSNP
rs2663704 371 dbSNP
rs900719833 378 dbSNP
rs1207234204 381 dbSNP
rs2555396 395 dbSNP
rs936952449 396 dbSNP
rs904084328 412 dbSNP
rs1312220155 416 dbSNP
rs1481188767 418 dbSNP
rs1226854199 419 dbSNP
rs545806518 422 dbSNP
rs1042409320 423 dbSNP
rs945327946 427 dbSNP
rs918013756 433 dbSNP
rs1369320799 435 dbSNP
rs1310210380 437 dbSNP
rs1430859425 441 dbSNP
rs1349684455 443 dbSNP
rs1056983620 444 dbSNP
rs1347170205 444 dbSNP
rs576414664 445 dbSNP
rs1403245845 448 dbSNP
rs1415258863 451 dbSNP
rs927141933 453 dbSNP
rs1223920977 454 dbSNP
rs1271472048 454 dbSNP
rs1342009361 454 dbSNP
rs1294314084 455 dbSNP
rs1196290014 456 dbSNP
rs1489965124 456 dbSNP
rs979905450 465 dbSNP
rs1475444248 477 dbSNP
rs963310576 479 dbSNP
rs1187715644 486 dbSNP
rs1188115219 489 dbSNP
rs909086017 493 dbSNP
rs1428957460 495 dbSNP
rs983146060 497 dbSNP
rs1472221222 507 dbSNP
rs950470095 514 dbSNP
rs1029996911 516 dbSNP
rs997245204 519 dbSNP
rs1433178487 521 dbSNP
rs1295443887 532 dbSNP
rs1364550159 533 dbSNP
rs112175992 534 dbSNP
rs1017739967 539 dbSNP
rs534151925 550 dbSNP
rs1357734334 560 dbSNP
rs1184053980 562 dbSNP
rs1480814061 572 dbSNP
rs1209671129 573 dbSNP
rs879138177 576 dbSNP
rs1223190502 591 dbSNP
rs1285420095 595 dbSNP
rs1447177314 600 dbSNP
rs1217503072 606 dbSNP
rs1000962568 607 dbSNP
rs904113675 611 dbSNP
rs1184130023 613 dbSNP
rs1042999747 623 dbSNP
rs1009813976 629 dbSNP
rs896517050 643 dbSNP
rs1408477002 645 dbSNP
rs1290679864 655 dbSNP
rs1227910229 656 dbSNP
rs1349155897 658 dbSNP
rs1290706277 660 dbSNP
rs1411002444 661 dbSNP
rs1367257535 663 dbSNP
rs2663705 664 dbSNP
rs1318799397 672 dbSNP
rs1387977488 672 dbSNP
rs1402596773 672 dbSNP
rs1453556473 674 dbSNP
rs1339230598 687 dbSNP
rs1339177390 688 dbSNP
rs1056449512 696 dbSNP
rs1314295694 698 dbSNP
rs1353306825 700 dbSNP
rs1433833421 712 dbSNP
rs938091440 718 dbSNP
rs1351325417 719 dbSNP
rs536744450 723 dbSNP
rs1044254202 726 dbSNP
rs1244464922 735 dbSNP
rs1440584649 740 dbSNP
rs1186752869 745 dbSNP
rs1456295427 748 dbSNP
rs1409169208 749 dbSNP
rs1471071233 752 dbSNP
rs1157210866 795 dbSNP
rs1161200446 809 dbSNP
rs1419616064 813 dbSNP
rs1178629863 815 dbSNP
rs1400166007 817 dbSNP
rs1395901334 819 dbSNP
rs1337901292 832 dbSNP
rs941809243 832 dbSNP
rs909040690 836 dbSNP
rs1286052760 848 dbSNP
rs1189323289 855 dbSNP
rs1223778227 856 dbSNP
rs1257172631 858 dbSNP
rs1342275543 859 dbSNP
rs983814531 859 dbSNP
rs1251238638 865 dbSNP
rs1489572501 876 dbSNP
rs1179810097 885 dbSNP
rs1250841716 886 dbSNP
rs574194846 895 dbSNP
rs1253925835 900 dbSNP
rs1208374493 901 dbSNP
rs1375987322 904 dbSNP
rs950646661 907 dbSNP
rs1289354367 908 dbSNP
rs1270093089 910 dbSNP
rs1229486387 912 dbSNP
rs1312177781 914 dbSNP
rs1399324696 914 dbSNP
rs1299637834 918 dbSNP
rs1221332154 921 dbSNP
rs1346540968 923 dbSNP
rs1369257172 926 dbSNP
rs1221390421 946 dbSNP
rs555638103 966 dbSNP
rs1328841271 968 dbSNP
rs1433911342 971 dbSNP
rs1251795389 972 dbSNP
rs1344165110 973 dbSNP
rs1202942860 985 dbSNP
rs1385734787 988 dbSNP
rs975690316 989 dbSNP
rs189594150 992 dbSNP
rs1454244983 997 dbSNP
rs1265589804 1004 dbSNP
rs111427619 1005 dbSNP
rs760766563 1008 dbSNP
rs778074713 1014 dbSNP
rs2663706 1015 dbSNP
rs1168520290 1016 dbSNP
rs1366566575 1017 dbSNP
rs550207332 1027 dbSNP
rs1000996777 1028 dbSNP
rs1388192536 1030 dbSNP
rs185421317 1033 dbSNP
rs1249962655 1035 dbSNP
rs1205858376 1036 dbSNP
rs1366758717 1049 dbSNP
rs1226068270 1055 dbSNP
rs193278044 1057 dbSNP
rs1359850881 1058 dbSNP
rs1223562590 1062 dbSNP
rs1263483484 1071 dbSNP
rs1254812848 1073 dbSNP
rs1236097464 1075 dbSNP
rs1348966124 1088 dbSNP
rs1297338637 1089 dbSNP
rs1188480301 1095 dbSNP
rs1021119029 1097 dbSNP
rs1227192901 1100 dbSNP
rs112836781 1113 dbSNP
rs1368285482 1114 dbSNP
rs1457046675 1120 dbSNP
rs896707992 1120 dbSNP
rs1056498258 1123 dbSNP
rs1390201336 1124 dbSNP
rs1299136519 1126 dbSNP
rs1382344141 1128 dbSNP
rs1400894886 1129 dbSNP
rs1300964439 1141 dbSNP
rs1383380533 1142 dbSNP
rs1467530358 1142 dbSNP
rs1310226589 1145 dbSNP
rs1002166951 1146 dbSNP
rs1375777084 1147 dbSNP
rs1327124224 1148 dbSNP
rs1167796486 1150 dbSNP
rs905285748 1156 dbSNP
rs1484502264 1159 dbSNP
rs12070 1160 dbSNP
rs1255890263 1164 dbSNP
rs1420126234 1169 dbSNP
rs1159406966 1175 dbSNP
rs1193966261 1177 dbSNP
rs1413786011 1180 dbSNP
rs1455340161 1183 dbSNP
rs1423269978 1185 dbSNP
rs1038500479 1187 dbSNP
rs1254207588 1191 dbSNP
rs1406173562 1192 dbSNP
rs1202641547 1198 dbSNP
rs941425981 1199 dbSNP
rs1274362241 1210 dbSNP
rs1391800478 1218 dbSNP
rs1303261353 1220 dbSNP
rs1290424536 1221 dbSNP
rs887632332 1223 dbSNP
rs1339605450 1228 dbSNP
rs1228048346 1232 dbSNP
rs1047545787 1234 dbSNP
rs1314079159 1236 dbSNP
rs1255961928 1243 dbSNP
rs1252648326 1245 dbSNP
rs1250101118 1250 dbSNP
rs1471365037 1252 dbSNP
rs1181032454 1256 dbSNP
rs373233462 1263 dbSNP
rs929226028 1268 dbSNP
rs1227744075 1269 dbSNP
rs1358557180 1274 dbSNP
rs1430359330 1284 dbSNP
rs1339299972 1288 dbSNP
rs14461 1288 dbSNP
rs1309977680 1289 dbSNP
rs1348402202 1289 dbSNP
rs923187514 1291 dbSNP
rs1284243352 1296 dbSNP
rs1369778862 1298 dbSNP
rs1356089378 1302 dbSNP
rs1217591934 1308 dbSNP
rs1300701338 1309 dbSNP
rs1308555079 1313 dbSNP
rs1207922348 1322 dbSNP
rs1272854826 1325 dbSNP
rs1482968807 1329 dbSNP
rs1203999360 1331 dbSNP
rs1307150291 1332 dbSNP
rs1478713522 1339 dbSNP
rs14462 1341 dbSNP
rs550998760 1348 dbSNP
rs1427638027 1351 dbSNP
rs1372203981 1353 dbSNP
rs1449931006 1356 dbSNP
rs1170428568 1357 dbSNP
rs975721354 1363 dbSNP
rs1168669631 1366 dbSNP
rs1457605434 1367 dbSNP
rs530985401 1368 dbSNP
rs943002521 1371 dbSNP
rs548670874 1372 dbSNP
rs1251788358 1384 dbSNP
rs1366032959 1390 dbSNP
rs1231245611 1398 dbSNP
rs1296136423 1404 dbSNP
rs1341862357 1405 dbSNP
rs1247237713 1406 dbSNP
rs1180673319 1408 dbSNP
rs1292497646 1413 dbSNP
rs1484216575 1414 dbSNP
rs910211000 1422 dbSNP
rs1245565235 1423 dbSNP
rs1195965711 1428 dbSNP
rs1355282107 1431 dbSNP
rs1263164657 1433 dbSNP
rs763180129 1439 dbSNP
rs1448813191 1440 dbSNP
rs1234641148 1444 dbSNP
rs1415697090 1447 dbSNP
rs1335370563 1450 dbSNP
rs1323204938 1455 dbSNP
rs1287595464 1456 dbSNP
rs1389468648 1458 dbSNP
rs1407333695 1462 dbSNP
rs1437425486 1464 dbSNP
rs72879406 1465 dbSNP
rs1365044724 1467 dbSNP
rs1337241337 1469 dbSNP
rs979190031 1472 dbSNP
rs72879404 1473 dbSNP
rs879071609 1476 dbSNP
rs1386420597 1480 dbSNP
rs1226246316 1487 dbSNP
rs1288752298 1492 dbSNP
rs1329211220 1493 dbSNP
rs878945762 1506 dbSNP
rs1210002264 1507 dbSNP
rs12372 1508 dbSNP
rs1464332866 1509 dbSNP
rs967804865 1510 dbSNP
rs758817349 1511 dbSNP
rs1461984440 1512 dbSNP
rs1411362421 1513 dbSNP
rs1162862859 1515 dbSNP
rs1413042327 1518 dbSNP
rs201993521 1522 dbSNP
rs1388003672 1526 dbSNP
rs752745086 1529 dbSNP
rs569051286 1538 dbSNP
rs1233807762 1540 dbSNP
rs1289395446 1541 dbSNP
rs1350681808 1546 dbSNP
rs1229855780 1554 dbSNP
rs1265630684 1563 dbSNP
rs1198688925 1566 dbSNP
rs1450658562 1567 dbSNP
rs1280705852 1572 dbSNP
rs562181044 1577 dbSNP
rs1440464265 1581 dbSNP
rs1157096245 1586 dbSNP
rs988304727 1590 dbSNP
rs1468507319 1602 dbSNP
rs1473658112 1602 dbSNP
rs961252148 1608 dbSNP
rs1411314480 1610 dbSNP
rs548053203 1621 dbSNP
rs1226483983 1622 dbSNP
rs1400629794 1622 dbSNP
rs369710086 1622 dbSNP
rs1414429271 1624 dbSNP
rs201406338 1626 dbSNP
rs1279886953 1628 dbSNP
rs1411259088 1638 dbSNP
rs1286140270 1639 dbSNP
rs1334634327 1640 dbSNP
rs111627074 1645 dbSNP
rs1329154570 1646 dbSNP
rs867505297 1648 dbSNP
rs1328119969 1649 dbSNP
rs1275015588 1655 dbSNP
rs1483947286 1663 dbSNP
rs1203279670 1673 dbSNP
rs905236343 1674 dbSNP
rs1016929100 1682 dbSNP
rs1441916798 1685 dbSNP
rs1006079642 1688 dbSNP
rs1376001390 1691 dbSNP
rs887168977 1692 dbSNP
rs1169842717 1696 dbSNP
rs1372788507 1708 dbSNP
rs1428261959 1709 dbSNP
rs1305777800 1718 dbSNP
rs1048039487 1724 dbSNP
rs929113740 1728 dbSNP
rs901762797 1732 dbSNP
rs1328863231 1734 dbSNP
rs1040302815 1741 dbSNP
rs1298324334 1742 dbSNP
rs112389810 1743 dbSNP
rs1172338649 1744 dbSNP
rs943287197 1745 dbSNP
rs1250580338 1747 dbSNP
rs910240309 1749 dbSNP
rs73959754 1752 dbSNP
rs1379764662 1753 dbSNP
rs1265338441 1757 dbSNP
rs1195040255 1762 dbSNP
rs546069289 1763 dbSNP
rs979052740 1772 dbSNP
rs1468654010 1782 dbSNP
rs1448233190 1786 dbSNP
rs1168312722 1799 dbSNP
rs946478011 1805 dbSNP
rs913612769 1806 dbSNP
rs1164695655 1807 dbSNP
rs1246878712 1809 dbSNP
rs1439573308 1812 dbSNP
rs1320667126 1813 dbSNP
rs368603325 1815 dbSNP
rs1448638029 1819 dbSNP
rs1322162725 1821 dbSNP
rs11390155 1834 dbSNP
rs764915860 1834 dbSNP
rs1334219006 1835 dbSNP
rs960938378 1838 dbSNP
rs1035186746 1840 dbSNP
rs1284804896 1842 dbSNP
rs1422647114 1843 dbSNP
rs1342529507 1845 dbSNP
rs1166434257 1847 dbSNP
rs192322949 1852 dbSNP
rs1460624947 1853 dbSNP
rs981046530 1857 dbSNP
rs1305372301 1868 dbSNP
rs1390220137 1870 dbSNP
rs1455564172 1873 dbSNP
rs1235276474 1876 dbSNP
rs1379581095 1877 dbSNP
rs1203052724 1879 dbSNP
rs969617144 1886 dbSNP
rs1229251158 1887 dbSNP
rs1270034270 1893 dbSNP
rs1327235557 1899 dbSNP
rs1016961001 1901 dbSNP
rs1295460991 1906 dbSNP
rs1005526246 1908 dbSNP
rs1180439982 1914 dbSNP
rs1474642121 1914 dbSNP
rs887191514 1915 dbSNP
rs1413522581 1923 dbSNP
rs1334039448 1926 dbSNP
rs1413272513 1931 dbSNP
rs111287728 1937 dbSNP
rs543021547 1945 dbSNP
rs1467554885 1948 dbSNP
rs1454423250 1950 dbSNP
rs574158259 1953 dbSNP
rs1374644732 1954 dbSNP
rs865962360 1959 dbSNP
rs1410656022 1970 dbSNP
rs554669123 1977 dbSNP
rs532297044 1983 dbSNP
rs901723981 1987 dbSNP
rs2663707 1988 dbSNP
rs1314384813 1991 dbSNP
rs1186304434 1995 dbSNP
rs534456776 1998 dbSNP
rs1280047988 2015 dbSNP
rs1483623631 2020 dbSNP
rs1040164062 2024 dbSNP
rs1186675110 2030 dbSNP
rs1253582545 2035 dbSNP
rs1479465583 2038 dbSNP
rs1176081602 2041 dbSNP
rs1007458862 2047 dbSNP
rs1434782951 2051 dbSNP
rs1182849955 2057 dbSNP
rs889002199 2074 dbSNP
rs573377314 2079 dbSNP
rs1430211878 2080 dbSNP
rs111915172 2082 dbSNP
rs1352931905 2083 dbSNP
rs1441755618 2088 dbSNP
rs946370632 2109 dbSNP
rs913551688 2113 dbSNP
rs1217972592 2114 dbSNP
rs1303362595 2118 dbSNP
rs1052231018 2126 dbSNP
rs1435651721 2127 dbSNP
rs1203394837 2131 dbSNP
rs939082190 2138 dbSNP
rs1216582040 2139 dbSNP
rs1362671441 2142 dbSNP
rs928147996 2153 dbSNP
rs980909244 2158 dbSNP
rs969645137 2159 dbSNP
rs1409592039 2173 dbSNP
rs1446444495 2179 dbSNP
rs1165835417 2192 dbSNP
rs553340416 2193 dbSNP
rs910093827 2205 dbSNP
rs1438861408 2206 dbSNP
rs1325324317 2208 dbSNP
rs984534252 2210 dbSNP
rs1429457159 2222 dbSNP
rs113200881 2225 dbSNP
rs1295789193 2226 dbSNP
rs1339208105 2232 dbSNP
rs1167793931 2237 dbSNP
rs1411310540 2241 dbSNP
rs1026062788 2246 dbSNP
rs540094274 2261 dbSNP
rs1180839310 2263 dbSNP
rs1211227057 2266 dbSNP
rs1272024793 2269 dbSNP
rs2663708 2290 dbSNP
rs1465245753 2294 dbSNP
rs1190495038 2298 dbSNP
rs1240139339 2302 dbSNP
rs1474983010 2305 dbSNP
rs371168297 2306 dbSNP
rs1474169394 2310 dbSNP
rs1259595635 2311 dbSNP
rs1188601565 2312 dbSNP
rs571170409 2318 dbSNP
rs1460097751 2320 dbSNP
rs965419911 2323 dbSNP
rs1459275120 2344 dbSNP
rs1018745810 2346 dbSNP
rs1326184109 2346 dbSNP
rs1449280287 2359 dbSNP
rs550961985 2360 dbSNP
rs1286346966 2364 dbSNP
rs1206822117 2366 dbSNP
rs1356932701 2369 dbSNP
rs1231081968 2377 dbSNP
rs1271973043 2381 dbSNP
rs1329322688 2386 dbSNP
rs1210479047 2390 dbSNP
rs1308361508 2392 dbSNP
rs1446376980 2403 dbSNP
rs1210507251 2406 dbSNP
rs1238991333 2407 dbSNP
rs1007309705 2412 dbSNP
rs889040821 2414 dbSNP
rs1289202343 2421 dbSNP
rs34392417 2422 dbSNP
rs34030856 2425 dbSNP
rs1384812366 2435 dbSNP
rs1415580371 2436 dbSNP
rs1043682292 2441 dbSNP
rs1294401135 2444 dbSNP
rs1409750222 2445 dbSNP
rs1412531890 2448 dbSNP
rs1292339611 2464 dbSNP
rs1283272922 2466 dbSNP
rs1240498081 2468 dbSNP
rs1277294351 2472 dbSNP
rs1349779207 2477 dbSNP
rs1348952587 2478 dbSNP
rs1300323786 2482 dbSNP
rs1443913836 2489 dbSNP
rs1282184320 2498 dbSNP
rs1484608627 2500 dbSNP
rs1210407424 2511 dbSNP
rs1252878492 2513 dbSNP
rs1354796763 2515 dbSNP
rs1179702801 2519 dbSNP
rs1363307995 2520 dbSNP
rs1011237818 2523 dbSNP
rs892157375 2526 dbSNP
rs1174894268 2529 dbSNP
rs1393622996 2531 dbSNP
rs1459372455 2544 dbSNP
rs1052520279 2552 dbSNP
rs112585382 2552 dbSNP
rs112206829 2553 dbSNP
rs1326212042 2554 dbSNP
rs140699989 2564 dbSNP
rs1405505053 2566 dbSNP
rs1233877331 2571 dbSNP
rs537465933 2572 dbSNP
rs939097744 2574 dbSNP
rs187137269 2576 dbSNP
rs1233232841 2585 dbSNP
rs1481069278 2586 dbSNP
rs1249901941 2592 dbSNP
rs1341656306 2592 dbSNP
rs201527075 2593 dbSNP
rs548646033 2595 dbSNP
rs1251624091 2598 dbSNP
rs528619507 2599 dbSNP
rs1169545001 2602 dbSNP
rs1392429263 2603 dbSNP
rs565863548 2604 dbSNP
rs1219682936 2607 dbSNP
rs551953673 2610 dbSNP
rs1395108804 2613 dbSNP
rs1469827356 2616 dbSNP
rs1273902200 2617 dbSNP
rs1228302530 2618 dbSNP
rs1327777443 2619 dbSNP
rs1297987702 2622 dbSNP
rs1328043160 2624 dbSNP
rs1225474956 2631 dbSNP
rs1309559036 2638 dbSNP
rs1357348410 2656 dbSNP
rs1215593516 2659 dbSNP
rs374225958 2661 dbSNP
rs1468381259 2662 dbSNP
rs1189839450 2664 dbSNP
rs1264291565 2672 dbSNP
rs1427152732 2673 dbSNP
rs1367378926 2680 dbSNP
rs1292543598 2681 dbSNP
rs1190553249 2685 dbSNP
rs111338701 2693 dbSNP
rs1372098028 2693 dbSNP
rs546581147 2693 dbSNP
rs1395964205 2694 dbSNP
rs1326066585 2698 dbSNP
rs1456635503 2703 dbSNP
rs1166385701 2714 dbSNP
rs1391669167 2721 dbSNP
rs1343406017 2725 dbSNP
rs1321182800 2735 dbSNP
rs1363788964 2739 dbSNP
rs1045258920 2747 dbSNP
rs1294623330 2753 dbSNP
rs1341219946 2758 dbSNP
rs1419408374 2761 dbSNP
rs1235381375 2762 dbSNP
rs879929232 2791 dbSNP
rs1424208870 2798 dbSNP
rs113013881 2812 dbSNP
rs1209874401 2816 dbSNP
rs1263070729 2818 dbSNP
rs1191917599 2820 dbSNP
rs1204881193 2825 dbSNP
rs1257307017 2836 dbSNP
rs1475298228 2837 dbSNP
rs1189699681 2842 dbSNP
rs1415018703 2851 dbSNP
rs1474621740 2855 dbSNP
rs1159223381 2857 dbSNP
rs948166803 2858 dbSNP
rs1451549864 2860 dbSNP
rs563255322 2876 dbSNP
rs1416848341 2881 dbSNP
rs910030480 2881 dbSNP
rs2847081 2884 dbSNP
rs1354880284 2891 dbSNP
rs1229033744 2911 dbSNP
rs541467171 2912 dbSNP
rs984426725 2912 dbSNP
rs918623950 2918 dbSNP
rs1485168006 2919 dbSNP
rs1262969779 2923 dbSNP
rs1486897529 2923 dbSNP
rs1212547188 2929 dbSNP
rs1254897160 2940 dbSNP
rs1485156741 2946 dbSNP
rs1217175953 2950 dbSNP
rs1177207356 2955 dbSNP
rs1409545225 2964 dbSNP
rs184271125 2969 dbSNP
rs529628802 2983 dbSNP
rs560763832 2984 dbSNP
rs1231611254 2986 dbSNP
rs1372809792 2993 dbSNP
rs1303463554 2996 dbSNP
rs1433646477 3001 dbSNP
rs1382181650 3003 dbSNP
rs1436411736 3003 dbSNP
rs1171552103 3004 dbSNP
rs1290489064 3006 dbSNP
rs977127402 3011 dbSNP
rs1454258602 3017 dbSNP
rs1299909306 3020 dbSNP
rs1358344092 3024 dbSNP
rs1171596606 3025 dbSNP
rs965451123 3032 dbSNP
rs541121204 3033 dbSNP
rs1302638743 3035 dbSNP
rs1350707563 3038 dbSNP
rs192246001 3048 dbSNP
rs560566072 3052 dbSNP
rs1006922199 3054 dbSNP
rs1346625082 3056 dbSNP
rs953252045 3062 dbSNP
rs1022530980 3063 dbSNP
rs1010854981 3066 dbSNP
rs1253497584 3073 dbSNP
rs1395968095 3074 dbSNP
rs1188194031 3082 dbSNP
rs1426773004 3090 dbSNP
rs1410736934 3091 dbSNP
rs892351261 3111 dbSNP
rs1352809861 3124 dbSNP
rs2663709 3126 dbSNP
rs1461500363 3130 dbSNP
rs1326697359 3140 dbSNP
rs1373740180 3142 dbSNP
rs1030685555 3143 dbSNP
rs572052554 3146 dbSNP
rs866565005 3155 dbSNP
rs1003172133 3159 dbSNP
rs553492444 3161 dbSNP
rs1407031819 3169 dbSNP
rs1203161480 3170 dbSNP
rs1273274797 3179 dbSNP
rs906288026 3203 dbSNP
rs1469719115 3206 dbSNP
rs1191736847 3223 dbSNP
rs1044868022 3235 dbSNP
rs1475643852 3239 dbSNP
rs1213520495 3244 dbSNP
rs947780425 3249 dbSNP
rs1349573491 3250 dbSNP
rs888644320 3253 dbSNP
rs1226245680 3254 dbSNP
rs1396850568 3256 dbSNP
rs1324112204 3257 dbSNP
rs113393854 3263 dbSNP
rs1325873392 3263 dbSNP
rs1346133903 3263 dbSNP
rs1049026544 3278 dbSNP
rs546435758 3279 dbSNP
rs577587092 3286 dbSNP
rs1378399665 3287 dbSNP
rs1293356326 3293 dbSNP
rs1336402753 3294 dbSNP
rs1211713910 3296 dbSNP
rs918810625 3312 dbSNP
rs201110668 3313 dbSNP
rs542285633 3317 dbSNP
rs537774842 3318 dbSNP
rs568431414 3319 dbSNP
rs1189002814 3320 dbSNP
rs1420074416 3322 dbSNP
rs112061294 3325 dbSNP
rs1164328174 3326 dbSNP
rs1460675098 3331 dbSNP
rs944077810 3338 dbSNP
rs201960490 3342 dbSNP
rs1423713973 3343 dbSNP
rs535070036 3347 dbSNP
rs201187807 3350 dbSNP
rs566048713 3359 dbSNP
rs985533835 3361 dbSNP
rs200047594 3363 dbSNP
rs1230876338 3369 dbSNP
rs1283090321 3371 dbSNP
rs968763444 3373 dbSNP
rs1225447430 3376 dbSNP
rs1281875277 3379 dbSNP
rs1211838125 3381 dbSNP
rs1446253621 3381 dbSNP
rs866738509 3382 dbSNP
rs551916572 3387 dbSNP
rs1484830631 3400 dbSNP
rs1187229635 3403 dbSNP
rs201820462 3405 dbSNP
rs1486164167 3408 dbSNP
rs1251560528 3412 dbSNP
rs866178207 3413 dbSNP
rs1407682908 3416 dbSNP
rs201213121 3418 dbSNP
rs1337112050 3422 dbSNP
rs113443401 3429 dbSNP
rs199917841 3431 dbSNP
rs1376856712 3432 dbSNP
rs1412551366 3436 dbSNP
rs1227577437 3438 dbSNP
rs1333547808 3444 dbSNP
rs1335899467 3447 dbSNP
rs1444256333 3448 dbSNP
rs138028912 3459 dbSNP
rs1031300711 3463 dbSNP
rs1003452140 3472 dbSNP
rs906235880 3474 dbSNP
rs530546048 3476 dbSNP
rs1345926191 3477 dbSNP
rs1012031272 3479 dbSNP
rs1355795587 3488 dbSNP
rs1307249453 3492 dbSNP
rs888165032 3493 dbSNP
rs1180264033 3504 dbSNP
rs1389886948 3508 dbSNP
rs1455111157 3517 dbSNP
rs1398959020 3519 dbSNP
rs1428672946 3526 dbSNP
rs1393717698 3534 dbSNP
rs1048573182 3538 dbSNP
rs201602141 3539 dbSNP
rs1457430021 3540 dbSNP
rs1415774468 3541 dbSNP
rs930095495 3548 dbSNP
rs1475853219 3550 dbSNP
rs1411105187 3551 dbSNP
rs2663710 3557 dbSNP
rs562921797 3559 dbSNP
rs75122528 3563 dbSNP
rs1375970752 3566 dbSNP
rs1180151799 3583 dbSNP
rs1441564480 3584 dbSNP
rs1041322058 3585 dbSNP
rs1305344018 3585 dbSNP
rs944275955 3589 dbSNP
rs1435691044 3595 dbSNP
rs1257512534 3596 dbSNP
rs1469292119 3598 dbSNP
rs911251889 3603 dbSNP
rs985401133 3604 dbSNP
rs1454146619 3620 dbSNP
rs1194373491 3623 dbSNP
rs1196050631 3625 dbSNP
rs1373246115 3629 dbSNP
rs1467587590 3643 dbSNP
rs1270746996 3645 dbSNP
rs111489747 3646 dbSNP
rs914602994 3653 dbSNP
rs549657246 3666 dbSNP
rs1391990276 3668 dbSNP
rs956779921 3669 dbSNP
rs1296067842 3677 dbSNP
rs1278705100 3687 dbSNP
rs1328358771 3687 dbSNP
rs112320484 3688 dbSNP
rs1277638818 3688 dbSNP
rs771273289 3688 dbSNP
rs529991518 3689 dbSNP
rs377692098 3691 dbSNP
rs1337335701 3700 dbSNP
rs1307889959 3702 dbSNP
rs560897852 3716 dbSNP
rs1206020239 3722 dbSNP
rs1440460130 3727 dbSNP
rs1448358927 3728 dbSNP
rs970619881 3728 dbSNP
rs1422246828 3733 dbSNP
rs1392358227 3736 dbSNP
rs878981043 3739 dbSNP
rs1011895316 3740 dbSNP
rs952497202 3741 dbSNP
rs187916861 3748 dbSNP
rs1027185527 3749 dbSNP
rs1356363583 3751 dbSNP
rs144427079 3756 dbSNP
rs1462394105 3761 dbSNP
rs199656900 3765 dbSNP
rs993930798 3768 dbSNP
rs1349035419 3770 dbSNP
rs1213979109 3775 dbSNP
rs897338699 3776 dbSNP
rs1485814879 3794 dbSNP
rs1189370186 3795 dbSNP
rs1253482785 3796 dbSNP
rs1471337341 3800 dbSNP
rs1423166630 3804 dbSNP
rs527346443 3809 dbSNP
rs1182014835 3810 dbSNP
rs1190700942 3814 dbSNP
rs1041183577 3816 dbSNP
rs1008448975 3817 dbSNP
rs890015820 3819 dbSNP
rs1215066470 3835 dbSNP
rs1049721497 3844 dbSNP
rs947343435 3850 dbSNP
rs1464172942 3855 dbSNP
rs1468842697 3860 dbSNP
rs1392451837 3864 dbSNP
rs1283415475 3870 dbSNP
rs867085325 3874 dbSNP
rs1239831700 3887 dbSNP
rs1203352301 3893 dbSNP
rs1352502144 3898 dbSNP
rs1053650656 3899 dbSNP
rs1348087629 3904 dbSNP
rs934741102 3908 dbSNP
rs1253706542 3909 dbSNP
rs923796834 3911 dbSNP
rs1279980166 3913 dbSNP
rs1437752894 3920 dbSNP
rs1177716015 3922 dbSNP
rs981912793 3924 dbSNP
rs1436813842 3925 dbSNP
rs1369097955 3930 dbSNP
rs1358630892 3937 dbSNP
rs1305686932 3940 dbSNP
rs970651104 3941 dbSNP
rs1371729700 3943 dbSNP
rs1441660437 3947 dbSNP
rs564853214 3950 dbSNP
rs1304613837 3962 dbSNP
rs1373695217 3967 dbSNP
rs1316778104 3971 dbSNP
rs1298674992 3973 dbSNP
rs1311279795 3978 dbSNP
rs990507673 3983 dbSNP
rs573735585 3984 dbSNP
rs1198005671 3992 dbSNP
rs545153252 3993 dbSNP
rs1253363065 3995 dbSNP
rs1189275268 3998 dbSNP
rs1455460321 3998 dbSNP
rs952524847 4000 dbSNP
rs1172551930 4019 dbSNP
rs1398280723 4020 dbSNP
rs1465562770 4037 dbSNP
rs577497704 4042 dbSNP
rs1386122883 4049 dbSNP
rs1026633541 4051 dbSNP
rs994352516 4057 dbSNP
rs1293308242 4058 dbSNP
rs1214854797 4062 dbSNP
rs1366393856 4062 dbSNP
rs1297092515 4063 dbSNP
rs557626384 4064 dbSNP
rs961084441 4069 dbSNP
rs544124878 4075 dbSNP
rs1008314542 4079 dbSNP
rs890045534 4079 dbSNP
rs1050002753 4080 dbSNP
rs1195138181 4084 dbSNP
rs1454303038 4085 dbSNP
rs1241029751 4088 dbSNP
rs1011827502 4093 dbSNP
rs575034732 4094 dbSNP
rs1448733323 4098 dbSNP
rs1284657607 4099 dbSNP
rs1404108507 4101 dbSNP
rs1209950627 4104 dbSNP
rs1323294690 4104 dbSNP
rs1345491959 4109 dbSNP
rs1346228423 4109 dbSNP
rs1282686356 4113 dbSNP
rs554905816 4118 dbSNP
rs1235300780 4121 dbSNP
rs1338765759 4122 dbSNP
rs534720296 4130 dbSNP
rs934753317 4137 dbSNP
rs1288878497 4139 dbSNP
rs543497786 4146 dbSNP
rs928680639 4152 dbSNP
rs1046263963 4153 dbSNP
rs201308089 4154 dbSNP
rs183738129 4163 dbSNP
rs1312629664 4164 dbSNP
rs1472093294 4165 dbSNP
rs1163229070 4180 dbSNP
rs760050103 4184 dbSNP
rs916415709 4194 dbSNP
rs991169676 4195 dbSNP
rs1157264444 4198 dbSNP
rs1413270773 4209 dbSNP
rs1377686746 4211 dbSNP
rs1418731999 4212 dbSNP
rs1175057362 4213 dbSNP
rs1261931995 4214 dbSNP
rs1341819271 4230 dbSNP
rs1414738118 4235 dbSNP
rs952646935 4236 dbSNP
rs1418158686 4238 dbSNP
rs919599643 4238 dbSNP
rs1241962208 4241 dbSNP
rs1283635403 4243 dbSNP
rs1353239731 4244 dbSNP
rs1211946665 4252 dbSNP
rs1165690981 4253 dbSNP
rs972404637 4257 dbSNP
rs1186960912 4261 dbSNP
rs558602320 4266 dbSNP
rs961116814 4267 dbSNP
rs773210437 4270 dbSNP
rs1019291404 4286 dbSNP
rs4113762 4288 dbSNP
rs1484528089 4291 dbSNP
rs1418714213 4292 dbSNP
rs1259374373 4295 dbSNP
rs34178594 4296 dbSNP
rs1173926887 4299 dbSNP
rs771864610 4302 dbSNP
rs986508296 4311 dbSNP
rs1332932340 4313 dbSNP
rs1354976183 4314 dbSNP
rs1307206680 4322 dbSNP
rs1448978445 4324 dbSNP
rs147231558 4327 dbSNP
rs1375927270 4330 dbSNP
rs1216454173 4339 dbSNP
rs1235271447 4340 dbSNP
rs569512733 4351 dbSNP
rs1028470931 4354 dbSNP
rs1343177226 4355 dbSNP
rs1293172684 4358 dbSNP
rs1012269998 4366 dbSNP
rs1232004432 4373 dbSNP
rs1848693 4378 dbSNP
rs1440049013 4379 dbSNP
rs1197380121 4388 dbSNP
rs536509850 4392 dbSNP
rs1237927830 4398 dbSNP
rs200834289 4408 dbSNP
rs1032107070 4418 dbSNP
rs1378932544 4419 dbSNP
rs1448259570 4423 dbSNP
rs1476843367 4427 dbSNP
rs998825962 4431 dbSNP
rs1353610893 4433 dbSNP
rs1419693953 4434 dbSNP
rs907294126 4449 dbSNP
rs1399487660 4451 dbSNP
rs1045882895 4455 dbSNP
rs948765539 4456 dbSNP
rs1329504624 4460 dbSNP
rs1232887283 4461 dbSNP
rs1411109980 4464 dbSNP
rs1320150076 4465 dbSNP
rs1217315744 4474 dbSNP
rs895009792 4476 dbSNP
rs1469305108 4478 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC
Disease MIMAT0027437
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC-D2
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1133252. RNA binding protein: AGO2. Condition:Untreated ...

- Majoros WH; Lekprasert P; Mukherjee N; et al., 2013, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cacguguccucuuacACCGGAAAc 5'
                         |||||||| 
Target 5' ----uuggcuauucuUGGCCUUUu 3'
 		1 - 20
Article - Majoros WH; Lekprasert P; Mukherjee N; et al.
- Nature methods, 2013
High-throughput sequencing has opened numerous possibilities for the identification of regulatory RNA-binding events. Cross-linking and immunoprecipitation of Argonaute proteins can pinpoint a microRNA (miRNA) target site within tens of bases but leaves the identity of the miRNA unresolved. A flexible computational framework, microMUMMIE, integrates sequence with cross-linking features and reliably identifies the miRNA family involved in each binding event. It considerably outperforms sequence-only approaches and quantifies the prevalence of noncanonical binding modes.
LinkOut: [PMID: 23708386]
CLIP-seq Support 1 for dataset GSM1020023
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000399799.2 | 3UTR | UUGGCUAUUCUUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1133252
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC-D2 / Untreated
Location of target site ENST00000399799.2 | 3UTR | UUGGCUAUUCUUGGCCUUUUGCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23708386 / GSE46611
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000399799.2 | 3UTR | UUGGCUAUUCUUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
95 hsa-miR-6768-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060980 LAMC1 laminin subunit gamma 1 2 2
MIRT145633 LASP1 LIM and SH3 protein 1 2 2
MIRT161065 CDV3 CDV3 homolog 2 2
MIRT161171 SLC25A36 solute carrier family 25 member 36 2 2
MIRT177407 ZMYND11 zinc finger MYND-type containing 11 2 2
MIRT262237 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT300236 INO80D INO80 complex subunit D 2 2
MIRT373993 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT379949 CRY2 cryptochrome circadian clock 2 2 2
MIRT405244 ADIPOR2 adiponectin receptor 2 2 2
MIRT441622 ROCK1 Rho associated coiled-coil containing protein kinase 1 2 6
MIRT441807 NOC3L NOC3 like DNA replication regulator 2 2
MIRT442007 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442254 DCTN5 dynactin subunit 5 2 2
MIRT442413 LIMD1 LIM domains containing 1 2 2
MIRT442741 SERINC5 serine incorporator 5 2 2
MIRT442796 CEP170 centrosomal protein 170 2 2
MIRT443332 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT443602 ZNF91 zinc finger protein 91 2 2
MIRT443695 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT443749 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT446376 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT452491 BANK1 B-cell scaffold protein with ankyrin repeats 1 2 16
MIRT456028 PSMA7 proteasome subunit alpha 7 2 2
MIRT461191 TRIP4 thyroid hormone receptor interactor 4 2 16
MIRT464498 UCK2 uridine-cytidine kinase 2 2 2
MIRT466640 TAOK1 TAO kinase 1 2 16
MIRT466703 TAF13 TATA-box binding protein associated factor 13 2 4
MIRT467765 SLC30A7 solute carrier family 30 member 7 2 2
MIRT469973 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT470539 COASY Coenzyme A synthase 2 2
MIRT474827 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT475961 GXYLT1 glucoside xylosyltransferase 1 2 4
MIRT476459 GBA2 glucosylceramidase beta 2 2 2
MIRT477658 EFNA1 ephrin A1 2 2
MIRT485320 MZT1 mitotic spindle organizing protein 1 2 4
MIRT485656 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT494145 CTC1 CST telomere replication complex component 1 2 10
MIRT495127 CXorf67 chromosome X open reading frame 67 2 2
MIRT498279 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT498432 DDX39A DExD-box helicase 39A 2 2
MIRT498853 LITAF lipopolysaccharide induced TNF factor 2 4
MIRT499661 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT502927 CDC42SE1 CDC42 small effector 1 2 4
MIRT503758 CEP19 centrosomal protein 19 2 6
MIRT507753 CERS2 ceramide synthase 2 2 4
MIRT507893 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 4
MIRT510091 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 8
MIRT527065 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT530314 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530702 P2RY1 purinergic receptor P2Y1 2 2
MIRT532378 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT532969 ZNF148 zinc finger protein 148 2 2
MIRT533958 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT535186 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT538751 CADM1 cell adhesion molecule 1 2 2
MIRT539473 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT543858 APIP APAF1 interacting protein 2 2
MIRT558802 CDON cell adhesion associated, oncogene regulated 2 2
MIRT560208 AK4 adenylate kinase 4 2 2
MIRT560318 EFHD2 EF-hand domain family member D2 2 2
MIRT560439 GOLGA7B golgin A7 family member B 2 2
MIRT560846 SUV39H2 suppressor of variegation 3-9 homolog 2 2 2
MIRT562787 LIMA1 LIM domain and actin binding 1 2 2
MIRT563476 POLE3 DNA polymerase epsilon 3, accessory subunit 2 2
MIRT563829 RIPK4 receptor interacting serine/threonine kinase 4 2 2
MIRT563996 SLFN11 schlafen family member 11 2 2
MIRT564596 ZNF791 zinc finger protein 791 2 2
MIRT565442 SURF4 surfeit 4 2 2
MIRT566020 RHOA ras homolog family member A 2 2
MIRT566185 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT567643 FAM160A1 family with sequence similarity 160 member A1 2 2
MIRT568484 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT568553 AKT2 AKT serine/threonine kinase 2 2 2
MIRT613420 XRCC3 X-ray repair cross complementing 3 2 2
MIRT613638 ARHGAP35 Rho GTPase activating protein 35 2 2
MIRT614841 POU2F2 POU class 2 homeobox 2 2 2
MIRT630143 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT634123 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT641841 TCF7L2 transcription factor 7 like 2 2 2
MIRT647123 ZNF446 zinc finger protein 446 2 2
MIRT647968 FBXO31 F-box protein 31 2 2
MIRT658186 FBXO9 F-box protein 9 2 2
MIRT659097 DENR density regulated re-initiation and release factor 2 2
MIRT668980 CLCN3 chloride voltage-gated channel 3 2 2
MIRT670351 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT671826 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT695610 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT697722 USP8 ubiquitin specific peptidase 8 2 2
MIRT700069 RPL14 ribosomal protein L14 2 2
MIRT708474 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT717001 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT719591 TFCP2L1 transcription factor CP2 like 1 2 2
MIRT722026 CBY3 chibby family member 3 2 2
MIRT722901 LRRC20 leucine rich repeat containing 20 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6768 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6768 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-6768 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-6768 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6768-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6768-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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