miRTarBase - #MIRT441887


—
pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol RD3   
Synonyms C1orf36, LCA12
Description retinal degeneration 3
Transcript NM_001164688   
Other Transcripts NM_183059   
Expression
Putative miRNA Targets on RD3
3'UTR of RD3
(miRNA target sites are highlighted)		 
>RD3|NM_001164688|3'UTR
   1 CCCCGGCCGCTTCCCTGCCCAGAAGCGGAGCCTTCTGCAGGGGGAATGATAGGCCGGTGACCGGAGCGCCGGGCCCTGGA
  81 ACCTCCCCACCTAGGCCTGACGAGGAGACCCAAGAGGCGGCCCCATCCCAAGACGCTGCTATAAAATGAAGCGACTCCCT
 161 GCCCCATCCTCTTCCTCTGGCCACAAAGCTGAGTTAGGTCGTAGAGCGGCACCGCCCTCTCCCTCTCCTGCGCTAGTCTG
 241 CAGGAGCAGCCCCTTCCCTAACTGGCAGATTCAAGGTTTTGGAAGACAGACCATTGCCCCATCCTCATCTCCTGGTTCTG
 321 TCTAAAAGGGGACAGTTGCCCTGCCTTTTGGCAAGACCTAGGTTCTCACCCCAATTTCAGGGATGTCCCATTCACCCCCC
 401 TACCCCCATCCCCAATGAGAAGGGACCTGTTGGCTGGTATGCCTTCTTGCTAGTGACTGGCTGAGCTCACCACTGCAGGT
 481 GGGTCACACACAGCCTCATAGGCAGGCACAGCTGGAAGGGACCAGAGAGACATTTAGATCCACTCTCTTCAGCTAGTAAA
 561 TGTGGAACTTGAGGCTCAGAGAGGGACACTTCTTCTGCCTTTAACTGCAGCCAGCTCCTCATGAACAGTGAGATTGTTCC
 641 TGCATGAATAGTGTCTGTTCCTGAGTTTGGAATCCTGGGCTATGAAGGGACAGGTCCAAAGGCTACATCTCTACCTACCT
 721 GTGGCCTGATCCATCTCTTACCTTGGCAGTGGGATGAGAATCTAAGCTGCTCTCCAAGAAGTGTAGCTAGGGGTGGAGGT
 801 AGGTTACTCATTACCCCACGCCACAATGTCATCGCATGGGCTGTGGCCAGTCCCTAACAGCTTCTTCCAGAGGCTCAGCT
 881 CCAAGGACTTCAGATGCTGCCCTAAAGAGCCCAGGTTTCTCAATTCCAGGGTTCCGCTTTCTGCAGCTGGTCACACCTGC
 961 TCTCTGGCTTTCTCCAGAAAGTGATGCCCAAACCCCTGACTGACCTTGAGGCAGCTGAGTGAAATGTTCTAGAAGAGCTT
1041 CCTGCAGCTTCATTGTCCTTCCCTTTTCTAACATGGTTAGGCCTTGATGATGGGCATGTGGATTACCCAATGTGTGGATC
1121 ACCCATGGAAAATCTGGAAGGCCAGGAGGCCTTCCCACACACTCTGGGGTTGAAGTGGGGTGTAAGGGGGATGGGTGGGG
1201 AAGTGTCTACCCTCAACTACCAGCACACATGCAGAAAATGCAAGTGGACCTTAATAGTAGCCTAAATAAAATACCCGGAG
1281 GAGATATAATCAACAGGGGGGAAAAGTGTGTATTCCCTCAGTGGAAAAAAGTTTTTTTGAATGATTTGGTTTTGAACTTC
1361 CCTTTTGAAGTTTTTTTGGATTTTCACTTGAATCTGGACAGAGAATCATAGGATGGTGGAAAACCTCTGATCCAACACTA
1441 TCAAGATGAAAGAGTTGATTGGCTTATTAATGTAATTGGTAGAAGTTGAGAATCACTTAAAATATACATCTTAAACATCT
1521 TACGTATTTTATTTGAAGACATAAAAAGTTCACTTGGTTGCCAAACTTTTTTTTTTTTTTTTGAGACTGAGTCTCACTCT
1601 GTTACCCAGGCTGCAGTGCAGTGGCGTGATCTCGGCTCACCACAACCTTTGCCTCCCGGGTTCAAGTGATTCTTCTGCCT
1681 CAGCCTCCTAAGTAGCTGGGACTACAGGCACGTGCCATCACCCCAGCTAATTTTTGTATTTTTATTAGAGATGGGGTTTC
1761 ACTATGTTGCCCAGAATGGTCTTGAACTCCTGACCTCGTGATCCACTCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGA
1841 CATGAGCCACTGTGCCTGGCTGCCAAACTTTTGATGTGGGTCCAAGCTGTGCTTTTTTGTGACCTATATGTTTTGTCTGG
1921 TGGGAGTTCTACACTTAAGTTTTCTTGGTTTGCACTTTAATCATAACAATAAGAACAACTGGCGTAAAAGAGTTTTGGAA
2001 CAAGCAGAAGTGACCCTTGGTAAGCAGACTGCTCAGCTGGTAGGGGCAAAAGTGTTGGGGGAGGATTAGAAAAAGGCCTC
2081 CACATTGTGGGCTTTCCGGGTGCCCTGGATGTGGGTCAGCAAATGTTTTAGAGGAAGTAGTTAACCTGGAGGGAGATTCA
2161 AAGGAGGCTGGATAAGAGAATGTCTATTTTTCTCCTTCCCTATCACCTTACATGTACCTATTCTCCCCAAAGAGAAGGAA
2241 GACCTTAGGCTTTCAATGTGGTGTTCTTTCTTAAGTTTAAGTAACTGGCTGCCAATGAAAACCTTCCCTTCGAGCCGCAG
2321 GCATGTGGACAGAATCCACCACCCTCCTTAGACACTCCTCAGACTACTACAGGCTATCCCCAGCTGGTGGCTCTCAAATT
2401 CATGAGGGTCCAGAAGTTGTTCCTCTGGATTCAGGTTGTTAAAGGGACTAATGAGGTCTGCTTCCATTACTATTATTGAA
2481 ACCTCAATAACCACAAATAAAAGAACAAAAAGTTAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauuuaGAGUAUCACGGAAGa 5'
                 || :|| ||||||| 
Target 5' ctgttggCTGGTA-TGCCTTCt 3'
 427 - 447 150.00 -14.80
2 
miRNA  3' agauuuaGAGUAUCACGGAAGa 5'
                 ||: |  ||||||: 
Target 5' agggacaCTTCTTCTGCCTTTa 3'
 582 - 603 131.00 -6.70
3 
miRNA  3' agauuuagaguaucACGGAAGa 5'
                        ||||||: 
Target 5' ggggacagttgcccTGCCTTTt 3'
 328 - 349 124.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
876620 44 ClinVar
295252 193 ClinVar
876619 213 ClinVar
876618 263 ClinVar
876617 330 ClinVar
295251 368 ClinVar
295250 471 ClinVar
295249 527 ClinVar
295248 590 ClinVar
875620 591 ClinVar
875619 592 ClinVar
295247 738 ClinVar
875618 814 ClinVar
874677 834 ClinVar
875617 834 ClinVar
295246 882 ClinVar
874676 1005 ClinVar
874675 1039 ClinVar
295245 1108 ClinVar
295244 1277 ClinVar
295243 1281 ClinVar
295242 1287 ClinVar
295241 1306 ClinVar
295240 1308 ClinVar
873705 1310 ClinVar
873704 1323 ClinVar
295239 1331 ClinVar
295238 1342 ClinVar
295237 1343 ClinVar
873703 1553 ClinVar
295236 1555 ClinVar
295234 1583 ClinVar
295235 1583 ClinVar
295233 1584 ClinVar
295232 1634 ClinVar
295231 1649 ClinVar
295230 1652 ClinVar
295229 1672 ClinVar
876565 1712 ClinVar
295228 1983 ClinVar
876564 2007 ClinVar
295227 2081 ClinVar
295226 2098 ClinVar
295225 2138 ClinVar
875568 2247 ClinVar
295224 2311 ClinVar
295223 2317 ClinVar
875567 2330 ClinVar
295222 2402 ClinVar
875566 2451 ClinVar
875565 2464 ClinVar
295221 2481 ClinVar
295220 2503 ClinVar
COSN30185661 4 COSMIC
COSN26548532 7 COSMIC
COSN30486173 14 COSMIC
COSN5737185 35 COSMIC
COSN30485946 43 COSMIC
COSN25580292 134 COSMIC
COSN21163009 309 COSMIC
COSN32055820 368 COSMIC
COSN29106844 735 COSMIC
COSN29881715 1158 COSMIC
COSN20095947 1306 COSMIC
COSN32125362 2007 COSMIC
COSN23064166 2289 COSMIC
COSN27085096 2384 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs967681688 1 dbSNP
rs1195310988 2 dbSNP
rs1484417420 3 dbSNP
rs1256168237 4 dbSNP
rs376035442 7 dbSNP
rs1313879269 8 dbSNP
rs1284125081 9 dbSNP
rs1270697249 14 dbSNP
rs1040238676 17 dbSNP
rs756977728 18 dbSNP
rs1394793089 19 dbSNP
rs1280374065 24 dbSNP
rs200694442 26 dbSNP
rs1354951067 27 dbSNP
rs764542676 29 dbSNP
rs910107855 31 dbSNP
rs570021034 34 dbSNP
rs35533609 35 dbSNP
rs536734715 36 dbSNP
rs759673196 37 dbSNP
rs776915905 38 dbSNP
rs771026640 39 dbSNP
rs551810206 41 dbSNP
rs773964686 42 dbSNP
rs768524149 43 dbSNP
rs1483915177 44 dbSNP
rs749154621 50 dbSNP
rs1203690020 51 dbSNP
rs1471626592 55 dbSNP
rs1176710793 70 dbSNP
rs896245235 74 dbSNP
rs1392994367 80 dbSNP
rs1162421633 85 dbSNP
rs1364791615 90 dbSNP
rs1429965829 101 dbSNP
rs1309430330 112 dbSNP
rs929628668 118 dbSNP
rs1408629245 119 dbSNP
rs1284282597 121 dbSNP
rs538892165 127 dbSNP
rs992584531 128 dbSNP
rs41275364 140 dbSNP
rs958659279 148 dbSNP
rs1034203590 152 dbSNP
rs978971728 153 dbSNP
rs371009085 164 dbSNP
rs1276975986 172 dbSNP
rs1482202264 178 dbSNP
rs1020195611 179 dbSNP
rs1009609377 181 dbSNP
rs892463293 183 dbSNP
rs1030041897 186 dbSNP
rs1238185644 188 dbSNP
rs11119748 193 dbSNP
rs771870212 197 dbSNP
rs899892784 200 dbSNP
rs1449797467 206 dbSNP
rs528315537 208 dbSNP
rs1163431259 209 dbSNP
rs1005662694 212 dbSNP
rs745612746 213 dbSNP
rs866205967 226 dbSNP
rs987315153 227 dbSNP
rs929679711 231 dbSNP
rs778556974 232 dbSNP
rs1335269377 235 dbSNP
rs1057175632 237 dbSNP
rs923807462 240 dbSNP
rs937118711 257 dbSNP
rs1340293656 258 dbSNP
rs927020253 273 dbSNP
rs979317794 276 dbSNP
rs978612768 277 dbSNP
rs1279387638 285 dbSNP
rs968537084 291 dbSNP
rs1251697423 292 dbSNP
rs1208142966 293 dbSNP
rs967941813 296 dbSNP
rs1490930987 311 dbSNP
rs1190270247 324 dbSNP
rs1292806853 330 dbSNP
rs1474863633 331 dbSNP
rs1023223168 334 dbSNP
rs1209401120 338 dbSNP
rs1354336814 339 dbSNP
rs752892465 340 dbSNP
rs990460517 343 dbSNP
rs913186412 358 dbSNP
rs1412217545 362 dbSNP
rs1947058 368 dbSNP
rs548620371 373 dbSNP
rs954572570 378 dbSNP
rs1165147808 380 dbSNP
rs1436546091 393 dbSNP
rs1239839965 395 dbSNP
rs530526540 399 dbSNP
rs1005073205 401 dbSNP
rs1347415622 404 dbSNP
rs748857743 405 dbSNP
rs1262663191 406 dbSNP
rs887280117 408 dbSNP
rs1210569748 409 dbSNP
rs998565081 413 dbSNP
rs964190817 415 dbSNP
rs1462697038 422 dbSNP
rs1199333642 427 dbSNP
rs1248032673 429 dbSNP
rs1347101480 439 dbSNP
rs1025819885 440 dbSNP
rs75135989 442 dbSNP
rs1412136970 445 dbSNP
rs1404470344 453 dbSNP
rs1388117561 461 dbSNP
rs34433079 471 dbSNP
rs1383470533 472 dbSNP
rs755635824 477 dbSNP
rs1047184214 479 dbSNP
rs1400437536 491 dbSNP
rs994395941 495 dbSNP
rs1324622770 499 dbSNP
rs896026175 502 dbSNP
rs544698797 505 dbSNP
rs1403402261 509 dbSNP
rs1411915442 509 dbSNP
rs373161189 519 dbSNP
rs754312692 520 dbSNP
rs942696127 521 dbSNP
rs1351226044 522 dbSNP
rs1230337882 526 dbSNP
rs886045899 527 dbSNP
rs1258841034 530 dbSNP
rs533653369 538 dbSNP
rs1481630169 539 dbSNP
rs927103532 542 dbSNP
rs1210140373 543 dbSNP
rs1291838788 545 dbSNP
rs1449497699 547 dbSNP
rs1198292238 549 dbSNP
rs1252132482 555 dbSNP
rs559832443 561 dbSNP
rs868754295 565 dbSNP
rs752125060 567 dbSNP
rs541605365 571 dbSNP
rs886045898 590 dbSNP
rs913071969 591 dbSNP
rs866479535 592 dbSNP
rs954664498 608 dbSNP
rs780639083 620 dbSNP
rs758825684 627 dbSNP
rs1422940410 629 dbSNP
rs750860166 632 dbSNP
rs979242718 634 dbSNP
rs574202043 636 dbSNP
rs964391608 643 dbSNP
rs1335086826 649 dbSNP
rs1245500692 651 dbSNP
rs556002199 658 dbSNP
rs1005602173 666 dbSNP
rs1286579620 677 dbSNP
rs916516063 682 dbSNP
rs1205830437 683 dbSNP
rs1483836956 688 dbSNP
rs766832307 691 dbSNP
rs1202402769 693 dbSNP
rs990725219 702 dbSNP
rs960393531 713 dbSNP
rs952761027 715 dbSNP
rs1267446769 716 dbSNP
rs1226429824 717 dbSNP
rs1370733832 721 dbSNP
rs1443109131 733 dbSNP
rs1025780089 735 dbSNP
rs886045897 738 dbSNP
rs191879930 744 dbSNP
rs1390947924 749 dbSNP
rs1275284851 757 dbSNP
rs896090555 762 dbSNP
rs950526478 771 dbSNP
rs1036348995 774 dbSNP
rs1001242641 777 dbSNP
rs1396711453 780 dbSNP
rs905533793 790 dbSNP
rs1042704321 791 dbSNP
rs1025787074 792 dbSNP
rs1244892350 803 dbSNP
rs1319835942 812 dbSNP
rs369781019 814 dbSNP
rs1387203753 817 dbSNP
rs139599545 819 dbSNP
rs550212567 820 dbSNP
rs1250238198 826 dbSNP
rs1483266697 831 dbSNP
rs1426465247 833 dbSNP
rs61849030 834 dbSNP
rs754020414 837 dbSNP
rs561278419 845 dbSNP
rs1183358521 848 dbSNP
rs764184328 852 dbSNP
rs975060125 855 dbSNP
rs1477223677 867 dbSNP
rs553037878 869 dbSNP
rs1168650248 873 dbSNP
rs866592052 881 dbSNP
rs760692968 882 dbSNP
rs1466567144 884 dbSNP
rs984056116 885 dbSNP
rs534919998 916 dbSNP
rs1051539166 918 dbSNP
rs1189395121 927 dbSNP
rs567082113 930 dbSNP
rs763805037 935 dbSNP
rs935396061 950 dbSNP
rs1367146764 956 dbSNP
rs1380347279 960 dbSNP
rs902618564 964 dbSNP
rs548778780 987 dbSNP
rs1025663904 994 dbSNP
rs1260778767 996 dbSNP
rs368752521 1000 dbSNP
rs186740910 1002 dbSNP
rs772066551 1004 dbSNP
rs571811935 1008 dbSNP
rs1248998367 1025 dbSNP
rs1487029331 1031 dbSNP
rs1185160505 1038 dbSNP
rs58551885 1039 dbSNP
rs939268392 1044 dbSNP
rs1201669626 1063 dbSNP
rs1002195854 1064 dbSNP
rs1218459787 1068 dbSNP
rs1342550811 1076 dbSNP
rs906090200 1082 dbSNP
rs1228598292 1088 dbSNP
rs538078525 1092 dbSNP
rs759365703 1094 dbSNP
rs1390773988 1105 dbSNP
rs1364001204 1106 dbSNP
rs151010298 1108 dbSNP
rs950470714 1111 dbSNP
rs1360286539 1118 dbSNP
rs920322752 1120 dbSNP
rs1334031608 1121 dbSNP
rs532831747 1122 dbSNP
rs1228502630 1126 dbSNP
rs1344362536 1126 dbSNP
rs1269260024 1132 dbSNP
rs1319258522 1133 dbSNP
rs1260569990 1142 dbSNP
rs1422018665 1146 dbSNP
rs1225056070 1147 dbSNP
rs1267078507 1158 dbSNP
rs1169620691 1182 dbSNP
rs375492423 1185 dbSNP
rs1183002192 1186 dbSNP
rs1409985405 1188 dbSNP
rs1011235038 1190 dbSNP
rs891575727 1191 dbSNP
rs1185543733 1194 dbSNP
rs1483595724 1204 dbSNP
rs962865731 1208 dbSNP
rs1459090399 1215 dbSNP
rs1238004937 1220 dbSNP
rs1209266399 1228 dbSNP
rs1052852939 1229 dbSNP
rs1440486941 1230 dbSNP
rs1276589256 1238 dbSNP
rs1409834537 1255 dbSNP
rs868277120 1260 dbSNP
rs955822103 1267 dbSNP
rs1029635456 1268 dbSNP
rs1306699507 1276 dbSNP
rs184525191 1277 dbSNP
rs73072853 1281 dbSNP
rs1038828170 1285 dbSNP
rs943301252 1286 dbSNP
rs748989370 1287 dbSNP
rs759829206 1289 dbSNP
rs1379191210 1292 dbSNP
rs772941536 1293 dbSNP
rs1010983523 1294 dbSNP
rs931308294 1297 dbSNP
rs1414482509 1299 dbSNP
rs1446176172 1302 dbSNP
rs894942120 1302 dbSNP
rs918703530 1304 dbSNP
rs886045896 1306 dbSNP
rs973235967 1307 dbSNP
rs142577368 1308 dbSNP
rs201369281 1308 dbSNP
rs193253076 1310 dbSNP
rs1380550318 1316 dbSNP
rs1368982191 1318 dbSNP
rs1036285556 1319 dbSNP
rs980267384 1330 dbSNP
rs11119747 1331 dbSNP
rs1358979514 1339 dbSNP
rs780834996 1342 dbSNP
rs11119746 1343 dbSNP
rs973148157 1360 dbSNP
rs1203938746 1372 dbSNP
rs955685533 1374 dbSNP
rs1237924346 1378 dbSNP
rs576584382 1381 dbSNP
rs1471801161 1390 dbSNP
rs1181514713 1392 dbSNP
rs1253852733 1393 dbSNP
rs1031310953 1397 dbSNP
rs964463155 1399 dbSNP
rs771664687 1405 dbSNP
rs558319539 1419 dbSNP
rs1416978932 1424 dbSNP
rs911361332 1430 dbSNP
rs577835306 1440 dbSNP
rs546173809 1447 dbSNP
rs1482581056 1452 dbSNP
rs375986615 1472 dbSNP
rs997679712 1476 dbSNP
rs1407465168 1486 dbSNP
rs61849029 1503 dbSNP
rs1455104677 1515 dbSNP
rs1335109998 1518 dbSNP
rs901571165 1523 dbSNP
rs1039306924 1524 dbSNP
rs1007373923 1531 dbSNP
rs1272096457 1550 dbSNP
rs887732929 1551 dbSNP
rs533275364 1553 dbSNP
rs554145853 1554 dbSNP
rs886045895 1555 dbSNP
rs918590551 1560 dbSNP
rs999811159 1566 dbSNP
rs1262470461 1567 dbSNP
rs1289482179 1567 dbSNP
rs1465144573 1572 dbSNP
rs966678456 1576 dbSNP
rs1037010523 1582 dbSNP
rs1022253996 1583 dbSNP
rs1471222370 1583 dbSNP
rs1474915051 1583 dbSNP
rs879756831 1583 dbSNP
rs886045894 1583 dbSNP
rs775682217 1584 dbSNP
rs1406020842 1588 dbSNP
rs777426977 1589 dbSNP
rs938777076 1604 dbSNP
rs928724452 1611 dbSNP
rs980702273 1612 dbSNP
rs1010911473 1616 dbSNP
rs779925721 1623 dbSNP
rs1349499253 1625 dbSNP
rs970211149 1625 dbSNP
rs188579275 1626 dbSNP
rs1402489148 1628 dbSNP
rs567242638 1629 dbSNP
rs990410422 1633 dbSNP
rs886045893 1634 dbSNP
rs1182746125 1640 dbSNP
rs956239287 1643 dbSNP
rs1472146250 1645 dbSNP
rs1031773730 1647 dbSNP
rs12076715 1649 dbSNP
rs184074454 1652 dbSNP
rs569405037 1657 dbSNP
rs1488631728 1658 dbSNP
rs544513757 1672 dbSNP
rs1160637446 1673 dbSNP
rs1218784211 1686 dbSNP
rs1330547320 1698 dbSNP
rs1007378664 1700 dbSNP
rs1400523685 1705 dbSNP
rs887618226 1708 dbSNP
rs1367703543 1711 dbSNP
rs190357778 1712 dbSNP
rs1282806218 1715 dbSNP
rs993393688 1716 dbSNP
rs1336263664 1717 dbSNP
rs754077555 1721 dbSNP
rs943071179 1723 dbSNP
rs910312093 1739 dbSNP
rs1349627497 1748 dbSNP
rs187444609 1750 dbSNP
rs934140901 1751 dbSNP
rs1489721814 1753 dbSNP
rs897716355 1754 dbSNP
rs1387682418 1755 dbSNP
rs922833042 1763 dbSNP
rs978272945 1770 dbSNP
rs1037467467 1781 dbSNP
rs938678837 1785 dbSNP
rs1362593168 1790 dbSNP
rs1469898547 1795 dbSNP
rs1291958798 1798 dbSNP
rs1387311387 1804 dbSNP
rs1423034918 1806 dbSNP
rs1433003720 1808 dbSNP
rs966940812 1809 dbSNP
rs928750862 1813 dbSNP
rs547385653 1814 dbSNP
rs1044478179 1816 dbSNP
rs989455745 1817 dbSNP
rs148459523 1827 dbSNP
rs1456697625 1841 dbSNP
rs562397642 1844 dbSNP
rs914749001 1849 dbSNP
rs755084919 1854 dbSNP
rs1356798144 1862 dbSNP
rs1244843791 1864 dbSNP
rs1251563297 1866 dbSNP
rs550383283 1874 dbSNP
rs1178016114 1875 dbSNP
rs1433516563 1878 dbSNP
rs1266262114 1882 dbSNP
rs113601846 1885 dbSNP
rs1437831247 1895 dbSNP
rs564704663 1899 dbSNP
rs1245406551 1900 dbSNP
rs924868423 1906 dbSNP
rs1026152256 1907 dbSNP
rs976191749 1908 dbSNP
rs1463539015 1910 dbSNP
rs756327680 1915 dbSNP
rs1166234338 1916 dbSNP
rs1395677652 1919 dbSNP
rs965730472 1930 dbSNP
rs1453358087 1938 dbSNP
rs1207541233 1942 dbSNP
rs993381894 1944 dbSNP
rs1463970718 1949 dbSNP
rs1380256758 1952 dbSNP
rs1258249374 1953 dbSNP
rs1451678175 1967 dbSNP
rs1234454487 1969 dbSNP
rs1295774898 1979 dbSNP
rs143085760 1983 dbSNP
rs985845709 1984 dbSNP
rs1317819116 1986 dbSNP
rs942998931 1992 dbSNP
rs1265572178 1999 dbSNP
rs951775249 2000 dbSNP
rs1027456684 2007 dbSNP
rs140867338 2010 dbSNP
rs1430586244 2016 dbSNP
rs1191096592 2020 dbSNP
rs1432951062 2026 dbSNP
rs1382738674 2029 dbSNP
rs1304468059 2032 dbSNP
rs1470363063 2032 dbSNP
rs1178441287 2036 dbSNP
rs933086433 2037 dbSNP
rs1469043683 2039 dbSNP
rs368150884 2055 dbSNP
rs922727025 2058 dbSNP
rs897760148 2061 dbSNP
rs1386670833 2068 dbSNP
rs1034942935 2078 dbSNP
rs1380222557 2079 dbSNP
rs886045892 2081 dbSNP
rs1376786927 2083 dbSNP
rs1345548995 2091 dbSNP
rs978243260 2097 dbSNP
rs886045891 2098 dbSNP
rs1322039249 2101 dbSNP
rs1044381137 2107 dbSNP
rs1261739361 2121 dbSNP
rs948803289 2126 dbSNP
rs886045890 2138 dbSNP
rs1447085988 2146 dbSNP
rs893198012 2147 dbSNP
rs182448832 2157 dbSNP
rs1054658944 2167 dbSNP
rs1427111657 2169 dbSNP
rs989717139 2172 dbSNP
rs1159540191 2178 dbSNP
rs934811609 2180 dbSNP
rs1201465668 2186 dbSNP
rs767461369 2187 dbSNP
rs924890097 2195 dbSNP
rs959626620 2205 dbSNP
rs1451394650 2208 dbSNP
rs1033723086 2220 dbSNP
rs976366662 2221 dbSNP
rs1365819983 2240 dbSNP
rs759544954 2241 dbSNP
rs1300818135 2242 dbSNP
rs1344156476 2245 dbSNP
rs190235544 2247 dbSNP
rs1308378458 2257 dbSNP
rs774103756 2258 dbSNP
rs1319055739 2259 dbSNP
rs1254689401 2272 dbSNP
rs1285496066 2273 dbSNP
rs1490594961 2281 dbSNP
rs970846644 2288 dbSNP
rs985731631 2289 dbSNP
rs1343194940 2295 dbSNP
rs951827098 2300 dbSNP
rs1006454750 2301 dbSNP
rs1488101207 2303 dbSNP
rs114964922 2309 dbSNP
rs766209664 2311 dbSNP
rs1417019769 2312 dbSNP
rs531858401 2315 dbSNP
rs368840244 2316 dbSNP
rs886045889 2317 dbSNP
rs1035233265 2318 dbSNP
rs1314774199 2323 dbSNP
rs1007517182 2330 dbSNP
rs1442329881 2340 dbSNP
rs888739373 2342 dbSNP
rs1376172397 2343 dbSNP
rs1396602182 2351 dbSNP
rs111251752 2357 dbSNP
rs905087602 2360 dbSNP
rs1248497959 2371 dbSNP
rs14148 2378 dbSNP
rs997647000 2390 dbSNP
rs1022987846 2395 dbSNP
rs1321144625 2398 dbSNP
rs886045888 2402 dbSNP
rs1234466308 2403 dbSNP
rs762587970 2408 dbSNP
rs1479655213 2409 dbSNP
rs1447141269 2419 dbSNP
rs1369765000 2422 dbSNP
rs1243577802 2444 dbSNP
rs893263220 2446 dbSNP
rs567341266 2451 dbSNP
rs1423796543 2453 dbSNP
rs934705791 2453 dbSNP
rs1409974567 2461 dbSNP
rs1171988742 2462 dbSNP
rs557944408 2464 dbSNP
rs373654186 2481 dbSNP
rs1184826738 2483 dbSNP
rs945533219 2484 dbSNP
rs41309617 2503 dbSNP
rs1274209926 2504 dbSNP
rs1203206328 2506 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agauuuaGAGUAUCACGGAAGa 5'
                 || :|| ||||||| 
Target 5' ---uuggCUGGUA-UGCCUUCu 3'
 		1 - 18
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC
Disease MIMAT0026621
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agauuuaGAGUAUCACGGAAGa 5'
                 || :|| ||||||| 
Target 5' ---uuggCUGGUA-UGCCUUCu 3'
 		1 - 18
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020023
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000367002.4 | 3UTR | UUGGCUGGUAUGCCUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000367002.4 | 3UTR | UUGGCUGGUAUGCCUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

Error report submission