pre-miRNA Information | |
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pre-miRNA | hsa-mir-4480 |
Genomic Coordinates | chr10: 12578753 - 12578823 |
Description | Homo sapiens miR-4480 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||
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Mature miRNA | hsa-miR-4480 | |||||||||||||||||||||
Sequence | 44| AGCCAAGUGGAAGUUACUUUA |64 | |||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||
Experiments | Illumina | |||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | RIMKLB | ||||||||||||||||||||
Synonyms | FAM80B, NAAGS, NAAGS-I | ||||||||||||||||||||
Description | ribosomal modification protein rimK like family member B | ||||||||||||||||||||
Transcript | NM_020734 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on RIMKLB | |||||||||||||||||||||
3'UTR of RIMKLB (miRNA target sites are highlighted) |
>RIMKLB|NM_020734|3'UTR 1 CTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTTTCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTG 81 TTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTGGAGAGAGTGGGAGATAGATGAGACCTCTGCT 161 AGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTATAGAAAAATGTCAGGCTCTCA 241 TAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTTTTCATGGTCCC 321 TTGCTTTTGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGATT 401 TGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTA 481 TTAACTAGCAGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCC 561 CGCTTAATTTGGTGGGAGGTCAAATTGAATATAACCCAATAAAGGCTTCTTAATGACAAAATTGGCATGTTTGCATGATG 641 AAATGGAAATGAACAGTATTGCAATGTCCGGTATACAAAATAACATTAATTCAATGTAGATAAAATTACACTAGTTTAAA 721 ATATGTGCATTCACTTGTATTTGTTAGTGTTTTAGTCTTTTTTGAAAGATGTGCTCTGTTAATGTTGCTTTTTTTTTTTT 801 TTTTAATACATGCTAGTCTAACATTTCCTGCTCTATGCCTGCATCTTTAACAATGGCCAAAGTGAAGAAAATGCTACCTT 881 TTTTGTTAACAAGACACTGACTTGAAACATGTACATTTAAAGCCTTTTATTTTTTCCCTTTTTGTTTTGGTAGTTGGGCA 961 TTTAAATAAGGACAAGGAAAAATATTTTTGGGGGCAAATCAAGAGCCTATGAGTTCTAAGTATAAAGCTGAAGTGATTTC 1041 GAATGCCAGCGTTATATATTTGCATTTTTCACATTTTACGAGGGAGTATATGTGTATGTGTGTGCACGCATGCATGTGTA 1121 TGTGTTTTGCTTTTTGTTTCCATCAACTAATCAAAAAGGATAATTTAGAAAATGGAGCATGATGGGAAACAGAGTTTTTG 1201 ACTTTAAAAAACAGATGAGTTGTTTTCATAAGTAGACTCCACTGGGGTAGAGGTATTCACCTTAAAACATAGGGTGAGTA 1281 GATGCTTTTTTAGGCCTTTTTGTGTATATGTACGTTGTTTGTTTTTTTCCTTTTGTTTCTAGCCTGTTCAGTGTACAGTT 1361 TATTCAAGGCTACATGCTTTTCTTTAATGCTTCTGGCTATGCATTTTCTCTTTTTACATATAGGATTTGGGATTGGGGGT 1441 GGGTTGGATGTTTTTGTTTGGGGACTTATTTAGTAGTATTGAGTCTCTTATAGCCCTACTCTTAAGCCTTCAATACTGTC 1521 CACTCTTTATATTCCTTTACTTGCAGAATTTATAAAAGCCCCCAAACTGCATATAATATGAGCCTTTAAAACATGGGTAA 1601 AACTAATCCCATTGATGGGTTTGGATGGTATGTTAAGAAATGGAGATGCTGCAGAGCCCAACGTAATTTTTTAAACAGCA 1681 AGTTTTCCATCTCCCTACGAATCCTCTGAAGCTTTTACCCAAGCCCTTTCTTGCCTCTCCAGTGCTATTTTCCTTCAGAT 1761 GGACCTTAAACATAATTTCTTGGACACTACTAGAGAGACTTCGAGGCAATAATAAAAGATCAGTATTAACCAGCTATAAC 1841 AGAGGTTTGATCATGCTTACTTGTACAGTTTTTCCCCCGTTTTAAAAAGGAATGTAATAAAATTTGTTTTTTCCATAGAA 1921 TTAAATAATATTAAAATTGAGTGAAAGGTTGATTGTTGATGAATAGAATAGTACCTCTCATCTGTGCAGTGTCTCATTTC 2001 ACCTCAGAGAAAAGGATACATAAGAGGAGTTTGTAATTTATCTTAGGATATTCTAATTGCATTTAAAAGAACTTATCTTG 2081 CGCAGGGTAAATGGGGGACTCACATACATATATTAATACCTCTGACTCATTAACAGAAAGAAATACTTGGTACTTCTTTC 2161 GCTGAATGACCATACTGTGGAGGATGCATACTATTTGGTATAGAGAAATAAATGAGGAAGAAAGAACTGCTTAATTAAAT 2241 TATCATTCATATGTTCATATAGAGACCATCTGGTTGCCATGTGTATTATGACACATACACTTTGAATAGTTACATATCAC 2321 AAGTATGTAGTTCATGTTTGTGTTGGTGGGGTAAGGCATCAGGAAAAATGTAGTTAGTCTTTTCTTAACTTATACCAAAT 2401 TAACCAACTATATTATAGGAAATATGTGAAATTAGTTCATTAGCTTTATTCACTATTATGCATTCACATGATATTAAAAC 2481 GTACACTCACATGTTAGAATGAAAAGAGCAGTAGTTATCTTAGATTTTAAAAACATGGATATCTTCTTGAATTCCTTCAA 2561 GATTGAGGTAGAGAATAAGAGCAAATCATTCTGGAAGTACCTTAAGGAAACAAACAGCAGCAGATATTTAGGTTAAACTT 2641 ATTTTCATAATTGTTTAATAACTTTTGTATAATCTTCATTGCTATTATGAGAGAGAATGTATATATCAAATATGTGTAAT 2721 GATAAAATCTGAATTGTAAAATTTTTGTATATTGTTAAAATTGTAATTCTAAATTGTATTTCAAAAATGATTATTTCTGA 2801 TATTGTTTTTATGTCACCCATGATGAAAACTGGACTTTATATATCTAAACATACAAGTATGAACTATTCTATTTAAAATT 2881 TTTAATAGTTTTTTTCTTTTTTGGTGCCTATAATTGATTGGTCATTTCTGCTGGCTTTTCTCCAATGAACATTGAAATCT 2961 TCCTGTATATGTTACCAATAAGAAAACTACCCTGGAACAGTAGAAAAACCCAACAAGAGACTTGGCATTCATCAAGCACA 3041 TTATCAGACTTTGAGAACATATTGAAGGCATTGACTTTGAAAATCATCTCTTTTTCTCAAGAAGAAAGCAATGGAGAAGC 3121 AAATTTGTTTCATTCAGTGAATCCCCAGTTTGGGGCTTGTGGGGCTTAGAGACATTGTGAAATCAAATCTTGTGTTATAC 3201 TTTTCTCCTGGCTCACTTTTTTTGAGAAGGTTTATGGGCTATTTGGCTGGTGAGACACGATCCCCTCCTAAGAAAATGTA 3281 GGTGCTCAGACAGGTAACCACTGCTGCTACTGTTTTTATTTGTTTGTTTGTTCAATTTTATTTAAGATTTGTTTTTGTTG 3361 TACTAGGATTTTAAAAAATGTAATATATTGCAGGATTTATAACCAGG Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | BC-3 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796040 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-3 / 4-Thiouridine |
Location of target site | ENST00000357529.3 | 3UTR | UUGGCAUUCAUCAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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117 hsa-miR-4480 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT056040 | MLLT10 | MLLT10, histone lysine methyltransferase DOT1L cofactor | 2 | 2 | ||||||||
MIRT091259 | FXR1 | FMR1 autosomal homolog 1 | 2 | 4 | ||||||||
MIRT117347 | MAPRE2 | microtubule associated protein RP/EB family member 2 | 2 | 2 | ||||||||
MIRT234960 | ZNF439 | zinc finger protein 439 | 2 | 4 | ||||||||
MIRT441356 | ZNF75A | zinc finger protein 75a | 2 | 2 | ||||||||
MIRT441426 | STXBP2 | syntaxin binding protein 2 | 2 | 2 | ||||||||
MIRT441455 | ZNF488 | zinc finger protein 488 | 2 | 4 | ||||||||
MIRT441524 | ZBTB10 | zinc finger and BTB domain containing 10 | 2 | 2 | ||||||||
MIRT441576 | EXOC5 | exocyst complex component 5 | 2 | 2 | ||||||||
MIRT441597 | ABCB5 | ATP binding cassette subfamily B member 5 | 2 | 6 | ||||||||
MIRT441610 | ATP13A4 | ATPase 13A4 | 2 | 2 | ||||||||
MIRT441698 | CIT | citron rho-interacting serine/threonine kinase | 2 | 2 | ||||||||
MIRT441714 | FGF9 | fibroblast growth factor 9 | 2 | 2 | ||||||||
MIRT441784 | MAPK8 | mitogen-activated protein kinase 8 | 2 | 4 | ||||||||
MIRT441795 | EXOSC2 | exosome component 2 | 2 | 2 | ||||||||
MIRT441868 | RNASEL | ribonuclease L | 2 | 2 | ||||||||
MIRT441900 | SLC9A8 | solute carrier family 9 member A8 | 2 | 6 | ||||||||
MIRT441919 | FAM217B | family with sequence similarity 217 member B | 2 | 2 | ||||||||
MIRT441928 | C1orf109 | chromosome 1 open reading frame 109 | 2 | 2 | ||||||||
MIRT441938 | RIMKLB | ribosomal modification protein rimK like family member B | 2 | 2 | ||||||||
MIRT442157 | DPY19L1 | dpy-19 like C-mannosyltransferase 1 | 2 | 2 | ||||||||
MIRT442172 | AZF1 | azoospermia factor 1 | 2 | 2 | ||||||||
MIRT442208 | IRS1 | insulin receptor substrate 1 | 2 | 2 | ||||||||
MIRT442237 | DDX19A | DEAD-box helicase 19A | 2 | 2 | ||||||||
MIRT442366 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | 2 | 2 | ||||||||
MIRT442572 | SDC1 | syndecan 1 | 2 | 2 | ||||||||
MIRT442604 | ZNF391 | zinc finger protein 391 | 2 | 2 | ||||||||
MIRT442609 | MRC1 | mannose receptor C-type 1 | 2 | 2 | ||||||||
MIRT442647 | POP4 | POP4 homolog, ribonuclease P/MRP subunit | 2 | 2 | ||||||||
MIRT442658 | OIP5 | Opa interacting protein 5 | 2 | 6 | ||||||||
MIRT442686 | COX15 | COX15, cytochrome c oxidase assembly homolog | 2 | 2 | ||||||||
MIRT442773 | JAG1 | jagged 1 | 2 | 2 | ||||||||
MIRT442785 | CHD8 | chromodomain helicase DNA binding protein 8 | 2 | 2 | ||||||||
MIRT442895 | PLCB3 | phospholipase C beta 3 | 2 | 2 | ||||||||
MIRT442941 | C17orf105 | chromosome 17 open reading frame 105 | 2 | 2 | ||||||||
MIRT442959 | SGCD | sarcoglycan delta | 2 | 2 | ||||||||
MIRT442998 | EDAR | ectodysplasin A receptor | 2 | 2 | ||||||||
MIRT443017 | C21orf91 | chromosome 21 open reading frame 91 | 2 | 2 | ||||||||
MIRT443064 | CASP5 | caspase 5 | 2 | 2 | ||||||||
MIRT443069 | ABLIM1 | actin binding LIM protein 1 | 2 | 2 | ||||||||
MIRT443208 | VPS36 | vacuolar protein sorting 36 homolog | 2 | 2 | ||||||||
MIRT443237 | ANKRD26 | ankyrin repeat domain 26 | 2 | 2 | ||||||||
MIRT443253 | A1CF | APOBEC1 complementation factor | 2 | 2 | ||||||||
MIRT443329 | JUN | Jun proto-oncogene, AP-1 transcription factor subunit | 2 | 2 | ||||||||
MIRT443333 | NRAS | NRAS proto-oncogene, GTPase | 2 | 2 | ||||||||
MIRT443349 | STX7 | syntaxin 7 | 2 | 2 | ||||||||
MIRT443452 | CLIC5 | chloride intracellular channel 5 | 2 | 2 | ||||||||
MIRT443547 | GPR35 | G protein-coupled receptor 35 | 2 | 2 | ||||||||
MIRT443616 | AVPR1A | arginine vasopressin receptor 1A | 2 | 2 | ||||||||
MIRT443626 | CPSF2 | cleavage and polyadenylation specific factor 2 | 2 | 2 | ||||||||
MIRT443730 | ALPK3 | alpha kinase 3 | 2 | 2 | ||||||||
MIRT443786 | ST13 | ST13, Hsp70 interacting protein | 2 | 2 | ||||||||
MIRT443852 | RGS6 | regulator of G protein signaling 6 | 2 | 2 | ||||||||
MIRT445483 | KLF5 | Kruppel like factor 5 | 2 | 2 | ||||||||
MIRT471105 | PHLDA2 | pleckstrin homology like domain family A member 2 | 2 | 2 | ||||||||
MIRT472329 | NETO2 | neuropilin and tolloid like 2 | 2 | 4 | ||||||||
MIRT472391 | NDRG3 | NDRG family member 3 | 2 | 2 | ||||||||
MIRT473522 | MAX | MYC associated factor X | 2 | 2 | ||||||||
MIRT473874 | MAFK | MAF bZIP transcription factor K | 2 | 6 | ||||||||
MIRT476021 | GTF2A1 | general transcription factor IIA subunit 1 | 2 | 2 | ||||||||
MIRT478320 | DDN | dendrin | 2 | 2 | ||||||||
MIRT492049 | TNFSF9 | TNF superfamily member 9 | 2 | 2 | ||||||||
MIRT494851 | ANKRD24 | ankyrin repeat domain 24 | 2 | 2 | ||||||||
MIRT494991 | TSSC1 | EARP complex and GARP complex interacting protein 1 | 2 | 2 | ||||||||
MIRT495034 | RASSF2 | Ras association domain family member 2 | 2 | 2 | ||||||||
MIRT495111 | NOL10 | nucleolar protein 10 | 2 | 2 | ||||||||
MIRT495113 | TRADD | TNFRSF1A associated via death domain | 2 | 2 | ||||||||
MIRT495131 | METTL24 | methyltransferase like 24 | 2 | 2 | ||||||||
MIRT495147 | STAC2 | SH3 and cysteine rich domain 2 | 2 | 2 | ||||||||
MIRT495297 | NUP54 | nucleoporin 54 | 2 | 2 | ||||||||
MIRT495341 | RTN2 | reticulon 2 | 2 | 2 | ||||||||
MIRT495347 | ATP5S | ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) | 2 | 2 | ||||||||
MIRT496682 | DUSP18 | dual specificity phosphatase 18 | 2 | 2 | ||||||||
MIRT496743 | TGFBR1 | transforming growth factor beta receptor 1 | 2 | 2 | ||||||||
MIRT496841 | KCNIP2 | potassium voltage-gated channel interacting protein 2 | 2 | 2 | ||||||||
MIRT496852 | GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 2 | 2 | ||||||||
MIRT496889 | FOXP1 | forkhead box P1 | 2 | 2 | ||||||||
MIRT496922 | CLMN | calmin | 2 | 2 | ||||||||
MIRT496990 | TMEM231 | transmembrane protein 231 | 2 | 2 | ||||||||
MIRT497002 | SNAP25 | synaptosome associated protein 25 | 2 | 2 | ||||||||
MIRT497058 | C6orf223 | chromosome 6 open reading frame 223 | 2 | 2 | ||||||||
MIRT500529 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | 2 | 6 | ||||||||
MIRT506048 | PPP6C | protein phosphatase 6 catalytic subunit | 2 | 4 | ||||||||
MIRT512163 | CD164 | CD164 molecule | 2 | 6 | ||||||||
MIRT527051 | RDH13 | retinol dehydrogenase 13 | 2 | 2 | ||||||||
MIRT532282 | TNFSF14 | TNF superfamily member 14 | 2 | 2 | ||||||||
MIRT534083 | SPRY4 | sprouty RTK signaling antagonist 4 | 2 | 2 | ||||||||
MIRT534605 | RNASEH1 | ribonuclease H1 | 2 | 4 | ||||||||
MIRT539509 | ACSS3 | acyl-CoA synthetase short chain family member 3 | 2 | 2 | ||||||||
MIRT543069 | ARID4B | AT-rich interaction domain 4B | 2 | 2 | ||||||||
MIRT544233 | CCBL2 | kynurenine aminotransferase 3 | 2 | 2 | ||||||||
MIRT544686 | ZNF224 | zinc finger protein 224 | 2 | 4 | ||||||||
MIRT546269 | TMEM30A | transmembrane protein 30A | 2 | 4 | ||||||||
MIRT559069 | C19orf47 | chromosome 19 open reading frame 47 | 2 | 2 | ||||||||
MIRT562768 | RMI2 | RecQ mediated genome instability 2 | 2 | 2 | ||||||||
MIRT563974 | HCFC1 | host cell factor C1 | 2 | 2 | ||||||||
MIRT564086 | NSA2 | NSA2, ribosome biogenesis homolog | 2 | 2 | ||||||||
MIRT564525 | PDXP | pyridoxal phosphatase | 2 | 2 | ||||||||
MIRT564613 | ZNF703 | zinc finger protein 703 | 2 | 2 | ||||||||
MIRT566252 | PTBP1 | polypyrimidine tract binding protein 1 | 2 | 2 | ||||||||
MIRT614420 | ZNF440 | zinc finger protein 440 | 2 | 2 | ||||||||
MIRT618789 | MTHFR | methylenetetrahydrofolate reductase | 2 | 2 | ||||||||
MIRT619160 | PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 2 | 2 | ||||||||
MIRT641778 | ZDHHC7 | zinc finger DHHC-type containing 7 | 2 | 4 | ||||||||
MIRT653680 | SLC25A36 | solute carrier family 25 member 36 | 2 | 2 | ||||||||
MIRT657861 | GJD2 | gap junction protein delta 2 | 2 | 2 | ||||||||
MIRT660879 | ADCYAP1R1 | ADCYAP receptor type I | 2 | 2 | ||||||||
MIRT668781 | DAAM1 | dishevelled associated activator of morphogenesis 1 | 2 | 4 | ||||||||
MIRT688559 | DCAF16 | DDB1 and CUL4 associated factor 16 | 2 | 2 | ||||||||
MIRT695393 | WDR41 | WD repeat domain 41 | 2 | 2 | ||||||||
MIRT698680 | TCEA1 | transcription elongation factor A1 | 2 | 2 | ||||||||
MIRT700974 | PDIA6 | protein disulfide isomerase family A member 6 | 2 | 2 | ||||||||
MIRT705055 | C5orf15 | chromosome 5 open reading frame 15 | 2 | 2 | ||||||||
MIRT705864 | AFF1 | AF4/FMR2 family member 1 | 2 | 2 | ||||||||
MIRT710586 | CDCA4 | cell division cycle associated 4 | 2 | 2 | ||||||||
MIRT713904 | IGF2R | insulin like growth factor 2 receptor | 2 | 2 | ||||||||
MIRT717133 | SKI | SKI proto-oncogene | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||
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