miRTarBase - #MIRT441948


—
pre-miRNA Information
pre-miRNA hsa-mir-4318   
Genomic Coordinates chr18: 37657135 - 37657215
Description Homo sapiens miR-4318 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4318
Sequence 55| CACUGUGGGUACAUGCU |71
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs753426994 4 dbSNP
rs1218438067 17 dbSNP
Putative Targets

Gene Information
Gene Symbol PEX2   
Synonyms PAF1, PBD5A, PBD5B, PMP3, PMP35, PXMP3, RNF72, ZWS3
Description peroxisomal biogenesis factor 2
Transcript NM_000318   
Other Transcripts NM_001079867 , NM_001172086 , NM_001172087   
Expression
Putative miRNA Targets on PEX2
3'UTR of PEX2
(miRNA target sites are highlighted)		 
>PEX2|NM_000318|3'UTR
   1 AAACTAAAATTGCTTCCTTTGAGGAAAAAAATGCACCGTGTTTAAATTCTTAATATTAGTCATCCTAAGTATACCATTTA
  81 TGTATCCTTTATAAGGAATGTGCTCCTAGCCACTGTCTTCTCCTTTCCAGGCATGACTGAAATCTAATCACTGGAAACCA
 161 TGTGATTCTAAATATATTATGTAAATGTTAATGTATTATGTTTTTTAAATCATTGCATTCAATTTTTAATGTCAAGAATA
 241 ATGGACAGCTTTTGTCAGGTGACTACTAACAATGCTCCTTCATTTTACTACTTCTTAAAACAAGGTTGGATTCTAAAGAT
 321 AAAGATTTTGGAGACTCTGGGATGAGTGTGCATTTATTTTCAGAGTTGACATAATATGATAATGTGACAATTATGAGACT
 401 GTTTTAAACCTTAAGACCTGATGCCTCAGTTGTAACTTTTTTTTTTTTTTCTGAGACGGTGTCCTGCTCTGTCACCCAGG
 481 CTGGAGTGCAGTGGCGCGATCTCTGCTCACTGCAACGTCCGCCTCCCGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCG
 561 AGTAGCTGGCACTGCAGGTGCATGCCACCATGCCCGGGTAATTTTTGTATTTTTAGTAGAGATGGGGTTCACTGTGTTAG
 641 CCAGGATGGTCTCTATCTCCTGATCTGGTGATCCACCTGCGTCAGCCTCCCAAAGTGCTGAGATTACAGACGTGAGCCAC
 721 TGTGCTTGGCCGCCTCAGTTGTAATGTTATGCTTTTCTCTGAAGCCAATTTTTAAGAAGTTCAGTCCTCAGCTGTCTGAC
 801 CCCTCCACAGTTGGCTTTATATTCAGAAAGTAAAAATTACTTAAGGCAGCTTGGAAGTGAGGCCTGGGAACTACTGGGGG
 881 CAACTAGTATGAACAGCACTATTTACAGGTCTCTTTCTCTTGCCTTTGATTCAGAGCTGTCATTCTCAGTAAATATTGAT
 961 AGTTTTATTGAAACAAAAGGGGTCTTTAGCATGGGAATAGTAACAGCAGTGCATAATCAAGATAATTCTGTATCCTTCAC
1041 TCTTTTTCTCTGCCTTTTTTTACTTAAAAGTAAATTCAGACTCTTAAAATGGTATAGAATTATTAGCTTGAACATTGAAT
1121 TATCTCGTCTTAACTAGAATGTTTTTTAAAAAACAGTTTTTAAATGTTTTTAAATAAACATCTTGCTAGTATGATGGAAA
1201 TACACTGCCAGTTCATTTTTCTCTTCACCTTTCATTGAACAAGTACTCAGGTGCCAGGTACTGATGTAGCCATTAGAGGC
1281 ACAACAGTATATTAAGCAGGAAAAATCAAGTTACCTTCATGGAGTTTACATTCTGTGATTGAATGAACTGTAAGTTTAAT
1361 TTAGGTTCAATTTAGTGTAAGATACTGAAGAAGTTTTGTAGTTTGAGTTAAGAGTATTTTACATCTTAAGAATTTGCCTT
1441 CTTTTGCCTTCTGTAATTTTAAAACATTATTGTAGAAAACACCAACAATTCAGGAAAAAATATAAAATCAACTTTCCCAC
1521 AATTTTTTGAGAGAGATCATCACTATATTTTACTATATTTGTAGATTTGTTGCACGTACATTTCTTATTTACAAAATTAT
1601 TATAATGCATAAAAAATAGCATTTTTTCCTATGTATAAATATTCTTCAAAACTATTTTAGGGCTGAGCACAATGGCTCAT
1681 GCCTGTAATCCCAGGCTCCCTACTTAGGGAGGCTGAGCCCAGGAGTTTGAGTTCGTTTCTAAAAAAATAAAAATATATAC
1761 AAACGTCTTTGTTTTTTGTTTGTTTGTTTGTTTTTGGTGAGAAAGGGCCTCACCCAGTCACCCAGGTTGGAGTGCAGTGG
1841 TGTGATCATGGCTAACCGCAGCCTTTCCCTCCCAGGGCTCAAGCGATCCTCCCATCTGAGCCTCCCAAGTTGCTGGGACC
1921 ACAGGCCCATACCACCATGCCTGGCTAATTTTTGTAGAGATGAGGTCTCACTTTGTTGCCCAGGCTGGTCTTGAACTTCT
2001 GGGCTCAAGCAGTCCTCCTACCCTGGCCTCCCAAAGTTGTGGGATTACAGGCATGAGCCACTGCACCCAGCCATAATATA
2081 TTTTTAAAATGCTATGTATATGCCATCATATTCCTATTCCTATTATTATTTAACCACCATCATAGAGCATTTAGGTTCTT
2161 TTCACTTTCTGTTGTGAATAATGCAATGTTGAATCTGAGTTCATTAAGTGAAGAGTCCAGCTGCACACTGCAGGCCCAGT
2241 CTGGATGTAGGTGCTCAGATGGTTCTCTTTGAGACAGGCTTTATCCTTTGGCTCTCATTTTTTTGATGAGTGTACATGGC
2321 ATGAGGGACACAGATTCCGCTAGAATTCAAATCCCACTTGTGTATAACCTAGGGCAATGTGCCACATCTCTGCACATCTG
2401 TTCATTGTAAGGATTACATGTTTAGTGTATATAAAGCTCTTAAAACAATGCCTGACACATAGTAAATAGAATATAATAGT
2481 AGTGCTTTCCTTTGCTGTTGTCAGTATTACTCTGAGTCGGTTTCATTCTCACACAGAATGATGGCCGCTAGAAGCTCAAG
2561 GCTTATAATCTGCTAGCTTTCTGATCCCACTGGCATGAGATACTCTTGCCTAATAGTTACAGCTAAAGTCCAGGAGCTCA
2641 CTGTTACTGGTCTGCCTTGGATTATGTGCACATTCCTGAACCAGCCACTATAGCTAGGGGATGGAAAATACTGTTCCTGG
2721 TTACTTAAATGTAGGTGATGCTCCTCCCATATACCACATGAACCTAAAGGAGTCCTGGAGGAGGCCGTTCACCACAGGAA
2801 ACTGAGGTGTTCTTAGAAGGGTGGATGCTGGCAGATCTCTACTAGTTAGAGTCTACATTTGCCTTACTCATTTCAAAAGT
2881 CCACATTGCAGTCTCATTTTACCAGTGATCTAGCTTGATAAGGACATTCATAAGTAACTGGATGATTCTTTAACATTGCA
2961 GATTTGAAAGGATTAAATAAAGTCAACAAAATTGTTATATCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucguacauGGGUGUCAc 5'
                  :||||||| 
Target 5' ctgaccccTCCACAGTt 3'
 796 - 812 141.00 -10.00
2 
miRNA  3' ucguACAUGGGUGUCac 5'
              || : ||||||  
Target 5' ttgcTGGGACCACAGgc 3'
 1910 - 1926 125.00 -12.20
3 
miRNA  3' ucguaCAUG-GGUGUCac 5'
               || | ||||||  
Target 5' aggccGTTCACCACAGga 3'
 2782 - 2799 124.00 -10.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
363815 37 ClinVar
363814 40 ClinVar
363813 91 ClinVar
363812 103 ClinVar
363811 233 ClinVar
363810 280 ClinVar
909226 319 ClinVar
363809 324 ClinVar
909225 394 ClinVar
909224 419 ClinVar
909223 437 ClinVar
363808 458 ClinVar
363807 489 ClinVar
909222 498 ClinVar
363806 595 ClinVar
908375 596 ClinVar
363805 627 ClinVar
908374 645 ClinVar
908373 659 ClinVar
908372 705 ClinVar
363804 727 ClinVar
911353 773 ClinVar
911352 780 ClinVar
911351 789 ClinVar
363803 819 ClinVar
363802 913 ClinVar
911350 1012 ClinVar
911349 1040 ClinVar
363801 1047 ClinVar
363800 1085 ClinVar
363799 1141 ClinVar
911147 1174 ClinVar
363798 1194 ClinVar
363797 1242 ClinVar
911146 1319 ClinVar
911145 1331 ClinVar
363796 1370 ClinVar
910260 1400 ClinVar
363795 1448 ClinVar
363794 1472 ClinVar
363793 1561 ClinVar
910259 1581 ClinVar
910258 1601 ClinVar
363792 1602 ClinVar
910257 1606 ClinVar
363791 1696 ClinVar
363790 1716 ClinVar
908304 1749 ClinVar
363789 1755 ClinVar
363788 1765 ClinVar
908303 1808 ClinVar
363787 1811 ClinVar
363786 1842 ClinVar
363785 1854 ClinVar
912308 1858 ClinVar
363784 1909 ClinVar
912307 2004 ClinVar
363783 2007 ClinVar
363782 2057 ClinVar
363781 2142 ClinVar
363780 2294 ClinVar
363779 2306 ClinVar
363778 2338 ClinVar
363777 2377 ClinVar
911072 2404 ClinVar
363776 2430 ClinVar
911071 2443 ClinVar
363775 2446 ClinVar
910190 2456 ClinVar
363774 2466 ClinVar
363773 2518 ClinVar
910189 2519 ClinVar
910188 2554 ClinVar
363772 2663 ClinVar
910187 2700 ClinVar
363771 2787 ClinVar
363770 2894 ClinVar
363769 2923 ClinVar
363768 2973 ClinVar
COSN30447710 16 COSMIC
COSN20057706 25 COSMIC
COSN31505148 38 COSMIC
COSN31505062 40 COSMIC
COSN26988663 55 COSMIC
COSN31520480 58 COSMIC
COSN31509431 59 COSMIC
COSN30181781 71 COSMIC
COSN30500640 84 COSMIC
COSN31507657 99 COSMIC
COSN31507668 100 COSMIC
COSN30107258 110 COSMIC
COSN30187616 162 COSMIC
COSN29019379 190 COSMIC
COSN2290367 229 COSMIC
COSN28219424 234 COSMIC
COSN24781978 285 COSMIC
COSN9680665 318 COSMIC
COSN17076209 394 COSMIC
COSN32061113 437 COSMIC
COSN2290366 712 COSMIC
COSN6363647 814 COSMIC
COSN195763 854 COSMIC
COSN25816550 1071 COSMIC
COSN32056962 1277 COSMIC
COSN9680664 1387 COSMIC
COSN14702585 1602 COSMIC
COSN25052240 1621 COSMIC
COSN15999711 1628 COSMIC
COSN8102028 1763 COSMIC
COSN20512361 1909 COSMIC
COSN20623630 1937 COSMIC
COSN17719676 1975 COSMIC
COSN30033559 2247 COSMIC
COSN6363646 2680 COSMIC
COSN9680663 2739 COSMIC
COSN9680662 2878 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs750044048 3 dbSNP
rs764867618 6 dbSNP
rs776341482 9 dbSNP
rs756793881 12 dbSNP
rs765608233 13 dbSNP
rs753871668 17 dbSNP
rs764109249 18 dbSNP
rs760452981 22 dbSNP
rs1161738121 24 dbSNP
rs760041400 25 dbSNP
rs1244607966 29 dbSNP
rs1380044514 31 dbSNP
rs775359513 32 dbSNP
rs767156920 33 dbSNP
rs1393495466 34 dbSNP
rs759836402 36 dbSNP
rs886063140 37 dbSNP
rs375166066 38 dbSNP
rs148915806 40 dbSNP
rs1164224396 44 dbSNP
rs770342305 47 dbSNP
rs1383605534 49 dbSNP
rs1020559959 58 dbSNP
rs1335890113 61 dbSNP
rs928498670 63 dbSNP
rs566672724 64 dbSNP
rs979812012 73 dbSNP
rs182029844 80 dbSNP
rs1203869738 81 dbSNP
rs1264776708 84 dbSNP
rs886063139 91 dbSNP
rs1371910534 96 dbSNP
rs529963492 103 dbSNP
rs948535396 107 dbSNP
rs1380799119 112 dbSNP
rs1251152088 120 dbSNP
rs112649342 126 dbSNP
rs756096226 127 dbSNP
rs1419786126 132 dbSNP
rs113776305 137 dbSNP
rs1054532073 144 dbSNP
rs1136687 150 dbSNP
rs932091535 159 dbSNP
rs900588266 160 dbSNP
rs1455267007 163 dbSNP
rs773468808 167 dbSNP
rs1480250233 173 dbSNP
rs944723012 180 dbSNP
rs746919227 181 dbSNP
rs1460772385 184 dbSNP
rs1298170845 187 dbSNP
rs989797988 193 dbSNP
rs955910925 194 dbSNP
rs912456128 195 dbSNP
rs982688908 205 dbSNP
rs1280850932 207 dbSNP
rs1031240700 211 dbSNP
rs1223763937 212 dbSNP
rs1284790912 215 dbSNP
rs978369008 217 dbSNP
rs1226382736 221 dbSNP
rs1251866533 224 dbSNP
rs190595998 233 dbSNP
rs1220108881 240 dbSNP
rs1030545442 244 dbSNP
rs531490407 248 dbSNP
rs996752835 251 dbSNP
rs919789713 256 dbSNP
rs570671917 265 dbSNP
rs1427147643 269 dbSNP
rs1016776583 275 dbSNP
rs1006195449 276 dbSNP
rs958659277 277 dbSNP
rs1034108683 280 dbSNP
rs886063138 280 dbSNP
rs981073007 293 dbSNP
rs1432173202 308 dbSNP
rs1301779471 312 dbSNP
rs78045204 319 dbSNP
rs1183160829 321 dbSNP
rs886063137 324 dbSNP
rs1427596698 349 dbSNP
rs1261786865 351 dbSNP
rs1381251538 368 dbSNP
rs1296061544 369 dbSNP
rs540996249 373 dbSNP
rs1290928494 377 dbSNP
rs1187786918 381 dbSNP
rs1223274674 383 dbSNP
rs1020530639 384 dbSNP
rs1010520129 394 dbSNP
rs1278814154 404 dbSNP
rs1485034524 424 dbSNP
rs527357278 429 dbSNP
rs1210536989 437 dbSNP
rs1262884147 439 dbSNP
rs1451709344 440 dbSNP
rs938633729 442 dbSNP
rs907041122 443 dbSNP
rs1424804056 448 dbSNP
rs1166318467 450 dbSNP
rs1342885156 451 dbSNP
rs1425127777 451 dbSNP
rs753445503 451 dbSNP
rs879056647 451 dbSNP
rs1349027190 452 dbSNP
rs1258204815 454 dbSNP
rs893296388 457 dbSNP
rs143201132 458 dbSNP
rs765902278 459 dbSNP
rs934331530 462 dbSNP
rs1315146259 463 dbSNP
rs1215414075 467 dbSNP
rs978337854 469 dbSNP
rs1182112901 475 dbSNP
rs1033556554 476 dbSNP
rs760357730 484 dbSNP
rs886063136 489 dbSNP
rs923526955 490 dbSNP
rs996367601 495 dbSNP
rs1056532102 496 dbSNP
rs1312213264 497 dbSNP
rs541772029 498 dbSNP
rs974911745 506 dbSNP
rs1390345312 508 dbSNP
rs965266826 509 dbSNP
rs900555945 510 dbSNP
rs773041848 515 dbSNP
rs1450145164 516 dbSNP
rs560480602 517 dbSNP
rs944693460 518 dbSNP
rs529676792 520 dbSNP
rs1046959404 521 dbSNP
rs1289278202 522 dbSNP
rs929936354 527 dbSNP
rs1201962110 528 dbSNP
rs1016329830 531 dbSNP
rs186116634 534 dbSNP
rs1443292771 536 dbSNP
rs544512470 538 dbSNP
rs779189607 539 dbSNP
rs974278097 542 dbSNP
rs1177250974 544 dbSNP
rs577157237 551 dbSNP
rs1413465181 560 dbSNP
rs1346332220 569 dbSNP
rs757493933 572 dbSNP
rs762495495 581 dbSNP
rs1429809851 588 dbSNP
rs1326823384 591 dbSNP
rs761398314 591 dbSNP
rs754113775 595 dbSNP
rs139852334 596 dbSNP
rs971038756 597 dbSNP
rs1012729439 602 dbSNP
rs1221920198 618 dbSNP
rs892988528 620 dbSNP
rs1346234382 625 dbSNP
rs1221263888 626 dbSNP
rs145960090 627 dbSNP
rs1054203168 631 dbSNP
rs1206415108 635 dbSNP
rs1252115383 635 dbSNP
rs868308811 636 dbSNP
rs571113679 638 dbSNP
rs1332753428 641 dbSNP
rs1198325732 644 dbSNP
rs1429521837 646 dbSNP
rs1292822331 648 dbSNP
rs934436202 657 dbSNP
rs551943990 659 dbSNP
rs957822780 663 dbSNP
rs1170344156 667 dbSNP
rs1372549035 674 dbSNP
rs1403173602 677 dbSNP
rs1302819669 680 dbSNP
rs1050714060 681 dbSNP
rs554781265 683 dbSNP
rs756456004 685 dbSNP
rs1339079356 687 dbSNP
rs923491065 693 dbSNP
rs181144845 695 dbSNP
rs975426948 699 dbSNP
rs569163196 705 dbSNP
rs909407665 707 dbSNP
rs984891880 711 dbSNP
rs1018974983 712 dbSNP
rs1416481060 721 dbSNP
rs767878551 722 dbSNP
rs4610720 727 dbSNP
rs1047679401 728 dbSNP
rs1180028687 729 dbSNP
rs1437626716 730 dbSNP
rs1251763602 731 dbSNP
rs560944085 732 dbSNP
rs1163030455 745 dbSNP
rs768644466 748 dbSNP
rs1272571921 750 dbSNP
rs898375839 754 dbSNP
rs749288918 756 dbSNP
rs1038307300 759 dbSNP
rs1358296614 767 dbSNP
rs937152606 768 dbSNP
rs1326279218 771 dbSNP
rs927177664 773 dbSNP
rs1300514340 780 dbSNP
rs971389987 783 dbSNP
rs1022869242 785 dbSNP
rs1336119503 787 dbSNP
rs144050052 789 dbSNP
rs1265521605 791 dbSNP
rs1438229260 793 dbSNP
rs1203066914 805 dbSNP
rs1283109168 810 dbSNP
rs1465210805 814 dbSNP
rs1190245487 815 dbSNP
rs886063135 819 dbSNP
rs949820648 823 dbSNP
rs1240985825 832 dbSNP
rs1443964732 837 dbSNP
rs1188086412 838 dbSNP
rs563103074 840 dbSNP
rs912995201 856 dbSNP
rs892967520 857 dbSNP
rs1157088373 864 dbSNP
rs1384500262 871 dbSNP
rs988448009 876 dbSNP
rs957078617 877 dbSNP
rs926180770 880 dbSNP
rs1452560596 884 dbSNP
rs189924371 899 dbSNP
rs1341812004 906 dbSNP
rs1236210360 907 dbSNP
rs1393440802 911 dbSNP
rs1210159373 912 dbSNP
rs886063134 913 dbSNP
rs759608289 915 dbSNP
rs552382825 917 dbSNP
rs1157326633 922 dbSNP
rs541192926 947 dbSNP
rs1201034234 948 dbSNP
rs1258144481 949 dbSNP
rs184269619 956 dbSNP
rs1179781076 957 dbSNP
rs1411283947 962 dbSNP
rs1473045745 963 dbSNP
rs1161573896 965 dbSNP
rs965236519 967 dbSNP
rs1303968857 980 dbSNP
rs1364709644 981 dbSNP
rs902903958 982 dbSNP
rs1390119445 985 dbSNP
rs1452765662 987 dbSNP
rs1350494417 988 dbSNP
rs1229867246 989 dbSNP
rs1252615546 990 dbSNP
rs547983856 991 dbSNP
rs1009024491 994 dbSNP
rs529651329 995 dbSNP
rs1233676800 997 dbSNP
rs1257491517 997 dbSNP
rs1479637373 1003 dbSNP
rs1195090478 1009 dbSNP
rs181539288 1012 dbSNP
rs1483413931 1014 dbSNP
rs1282323758 1017 dbSNP
rs764731692 1018 dbSNP
rs1184690169 1019 dbSNP
rs995221194 1022 dbSNP
rs1039282828 1028 dbSNP
rs1177273854 1030 dbSNP
rs1379692343 1034 dbSNP
rs1351369605 1035 dbSNP
rs77507591 1038 dbSNP
rs139337482 1040 dbSNP
rs1411098831 1042 dbSNP
rs565272439 1044 dbSNP
rs886063133 1047 dbSNP
rs1303715323 1052 dbSNP
rs905691292 1071 dbSNP
rs1438244180 1081 dbSNP
rs1045550378 1084 dbSNP
rs886063132 1085 dbSNP
rs929489905 1092 dbSNP
rs1317072098 1093 dbSNP
rs1226678089 1099 dbSNP
rs1400616558 1126 dbSNP
rs540392915 1127 dbSNP
rs1207348109 1128 dbSNP
rs561586284 1130 dbSNP
rs1160755378 1137 dbSNP
rs10108054 1141 dbSNP
rs1488296543 1147 dbSNP
rs1269927348 1148 dbSNP
rs981516019 1148 dbSNP
rs1188531560 1156 dbSNP
rs1427094244 1156 dbSNP
rs1194495840 1160 dbSNP
rs572125860 1173 dbSNP
rs562263817 1174 dbSNP
rs1432118170 1175 dbSNP
rs542767262 1186 dbSNP
rs1023426725 1191 dbSNP
rs4311633 1194 dbSNP
rs1359682516 1195 dbSNP
rs1434042768 1202 dbSNP
rs957480913 1211 dbSNP
rs539384966 1212 dbSNP
rs1367291383 1237 dbSNP
rs73691481 1242 dbSNP
rs1289686917 1245 dbSNP
rs1321137513 1245 dbSNP
rs1265256795 1246 dbSNP
rs1222660625 1247 dbSNP
rs1208391748 1256 dbSNP
rs1267424222 1258 dbSNP
rs998662856 1261 dbSNP
rs1208523282 1275 dbSNP
rs1248993487 1286 dbSNP
rs1451888622 1296 dbSNP
rs1182225247 1299 dbSNP
rs964952622 1299 dbSNP
rs903040099 1300 dbSNP
rs747376744 1304 dbSNP
rs539067985 1307 dbSNP
rs912151931 1319 dbSNP
rs987570126 1329 dbSNP
rs950900674 1331 dbSNP
rs746752479 1333 dbSNP
rs1337097123 1338 dbSNP
rs1450371511 1341 dbSNP
rs973541542 1343 dbSNP
rs1378620555 1345 dbSNP
rs1228940728 1353 dbSNP
rs997971471 1364 dbSNP
rs1327385213 1367 dbSNP
rs1227947332 1368 dbSNP
rs886063131 1370 dbSNP
rs1430825535 1377 dbSNP
rs1202407161 1379 dbSNP
rs558655567 1379 dbSNP
rs1237377600 1380 dbSNP
rs1483316793 1386 dbSNP
rs1183115923 1390 dbSNP
rs1033723168 1392 dbSNP
rs1341611672 1393 dbSNP
rs1405110223 1393 dbSNP
rs1472062040 1397 dbSNP
rs1133474 1399 dbSNP
rs1002618013 1400 dbSNP
rs577174721 1403 dbSNP
rs189268555 1405 dbSNP
rs1333485373 1407 dbSNP
rs1375187423 1410 dbSNP
rs1450083076 1423 dbSNP
rs775425012 1430 dbSNP
rs1304666065 1431 dbSNP
rs1014078952 1437 dbSNP
rs1177309391 1438 dbSNP
rs184740361 1448 dbSNP
rs1409507251 1450 dbSNP
rs1417676620 1451 dbSNP
rs1331713245 1456 dbSNP
rs1217807902 1461 dbSNP
rs1053274166 1471 dbSNP
rs552746754 1472 dbSNP
rs1478197640 1477 dbSNP
rs935807458 1479 dbSNP
rs1425944860 1485 dbSNP
rs904275605 1485 dbSNP
rs981488398 1489 dbSNP
rs1253487021 1493 dbSNP
rs950137720 1511 dbSNP
rs1485328978 1515 dbSNP
rs1038665426 1518 dbSNP
rs943050121 1519 dbSNP
rs916004582 1537 dbSNP
rs771887257 1545 dbSNP
rs1168221146 1547 dbSNP
rs868781292 1554 dbSNP
rs886063130 1561 dbSNP
rs957410211 1573 dbSNP
rs929461800 1574 dbSNP
rs919466864 1575 dbSNP
rs973893904 1578 dbSNP
rs1434528768 1580 dbSNP
rs1214852177 1581 dbSNP
rs1033322496 1597 dbSNP
rs566557726 1598 dbSNP
rs963454756 1599 dbSNP
rs116949534 1601 dbSNP
rs557330187 1602 dbSNP
rs1355406878 1604 dbSNP
rs1205282472 1605 dbSNP
rs1276104967 1606 dbSNP
rs1303748041 1609 dbSNP
rs1197651395 1617 dbSNP
rs1450643039 1617 dbSNP
rs980773874 1617 dbSNP
rs534070427 1619 dbSNP
rs1389462053 1628 dbSNP
rs1430271134 1635 dbSNP
rs899548154 1637 dbSNP
rs1018037554 1638 dbSNP
rs970742666 1641 dbSNP
rs1024215951 1644 dbSNP
rs1425835331 1653 dbSNP
rs1133475 1659 dbSNP
rs1014214908 1662 dbSNP
rs535961581 1664 dbSNP
rs1162943419 1676 dbSNP
rs891633292 1678 dbSNP
rs1439014346 1690 dbSNP
rs112199677 1696 dbSNP
rs1000447819 1697 dbSNP
rs1365142135 1701 dbSNP
rs904245464 1709 dbSNP
rs1229705460 1713 dbSNP
rs192555214 1716 dbSNP
rs1183319644 1718 dbSNP
rs1208942536 1721 dbSNP
rs943019075 1725 dbSNP
rs1049288683 1729 dbSNP
rs890146951 1732 dbSNP
rs531996863 1734 dbSNP
rs574981761 1735 dbSNP
rs1045841728 1748 dbSNP
rs556984036 1749 dbSNP
rs1212556305 1750 dbSNP
rs867412874 1753 dbSNP
rs1471848031 1754 dbSNP
rs886063129 1755 dbSNP
rs187490640 1756 dbSNP
rs935984909 1757 dbSNP
rs369118275 1758 dbSNP
rs925980011 1761 dbSNP
rs1428654491 1764 dbSNP
rs60300869 1765 dbSNP
rs1323136581 1778 dbSNP
rs967250292 1782 dbSNP
rs1279385252 1785 dbSNP
rs1447771962 1788 dbSNP
rs1358061015 1791 dbSNP
rs1226115797 1792 dbSNP
rs746680671 1794 dbSNP
rs976554864 1794 dbSNP
rs926710193 1796 dbSNP
rs1402762701 1800 dbSNP
rs1323930294 1803 dbSNP
rs980881594 1808 dbSNP
rs886063128 1811 dbSNP
rs1350595208 1812 dbSNP
rs1166820626 1813 dbSNP
rs970710163 1816 dbSNP
rs1476317853 1822 dbSNP
rs1157204310 1823 dbSNP
rs917964539 1825 dbSNP
rs1398918081 1829 dbSNP
rs1406950939 1831 dbSNP
rs1005330978 1832 dbSNP
rs184573256 1842 dbSNP
rs1025223736 1850 dbSNP
rs886063127 1854 dbSNP
rs192435069 1857 dbSNP
rs777834563 1858 dbSNP
rs1341674529 1861 dbSNP
rs1407672910 1865 dbSNP
rs1287316726 1867 dbSNP
rs1329652018 1875 dbSNP
rs1229978605 1876 dbSNP
rs575631413 1880 dbSNP
rs1014817437 1884 dbSNP
rs894669333 1885 dbSNP
rs1257023307 1891 dbSNP
rs1486693722 1893 dbSNP
rs1180344218 1906 dbSNP
rs112352942 1909 dbSNP
rs1315716897 1910 dbSNP
rs968978148 1913 dbSNP
rs1161778712 1929 dbSNP
rs936141374 1931 dbSNP
rs1465988418 1932 dbSNP
rs752992393 1939 dbSNP
rs1241369798 1940 dbSNP
rs1007296563 1941 dbSNP
rs1301506897 1942 dbSNP
rs1427226208 1942 dbSNP
rs747276777 1947 dbSNP
rs1350751929 1954 dbSNP
rs1411232153 1955 dbSNP
rs890117235 1964 dbSNP
rs1051331336 1966 dbSNP
rs568551631 1967 dbSNP
rs1298941357 1969 dbSNP
rs1330288236 1974 dbSNP
rs755651318 1979 dbSNP
rs148385937 1996 dbSNP
rs55886246 1999 dbSNP
rs117344716 2004 dbSNP
rs558850392 2007 dbSNP
rs942200059 2008 dbSNP
rs1273966803 2015 dbSNP
rs926818784 2019 dbSNP
rs964207977 2020 dbSNP
rs1265775048 2021 dbSNP
rs1432960141 2022 dbSNP
rs1451476359 2027 dbSNP
rs1397402046 2030 dbSNP
rs533836425 2040 dbSNP
rs573137904 2041 dbSNP
rs750090704 2046 dbSNP
rs1370573717 2051 dbSNP
rs1344567657 2053 dbSNP
rs568202276 2057 dbSNP
rs1291425725 2060 dbSNP
rs1272904484 2065 dbSNP
rs984362612 2067 dbSNP
rs952430618 2073 dbSNP
rs538325823 2086 dbSNP
rs752091971 2094 dbSNP
rs949411740 2098 dbSNP
rs918015915 2104 dbSNP
rs988114135 2108 dbSNP
rs956941906 2118 dbSNP
rs764682443 2122 dbSNP
rs1206966917 2126 dbSNP
rs970388608 2139 dbSNP
rs1488388293 2140 dbSNP
rs79700176 2142 dbSNP
rs968572475 2143 dbSNP
rs1448210205 2145 dbSNP
rs1181555015 2147 dbSNP
rs776248796 2149 dbSNP
rs1184283686 2161 dbSNP
rs1007349010 2169 dbSNP
rs954428336 2180 dbSNP
rs1458057618 2181 dbSNP
rs1263110242 2184 dbSNP
rs1034486522 2186 dbSNP
rs1000780993 2191 dbSNP
rs536481633 2192 dbSNP
rs1362801169 2196 dbSNP
rs568579885 2205 dbSNP
rs1443340085 2209 dbSNP
rs993106397 2229 dbSNP
rs1313019693 2234 dbSNP
rs796331465 2239 dbSNP
rs897513302 2245 dbSNP
rs1361114218 2247 dbSNP
rs1298720980 2251 dbSNP
rs942592856 2252 dbSNP
rs188202201 2255 dbSNP
rs1373362929 2269 dbSNP
rs1179635754 2271 dbSNP
rs1312104166 2271 dbSNP
rs983940694 2279 dbSNP
rs1424038562 2282 dbSNP
rs1166635396 2285 dbSNP
rs763651452 2294 dbSNP
rs1159885060 2305 dbSNP
rs774320077 2305 dbSNP
rs918315826 2305 dbSNP
rs59296540 2306 dbSNP
rs1379043241 2309 dbSNP
rs1301172833 2310 dbSNP
rs1378453460 2313 dbSNP
rs1415698864 2325 dbSNP
rs534907679 2328 dbSNP
rs1295317085 2332 dbSNP
rs1327586546 2335 dbSNP
rs56231626 2338 dbSNP
rs1427392748 2339 dbSNP
rs1423798660 2342 dbSNP
rs1254958718 2345 dbSNP
rs1194987439 2350 dbSNP
rs1199213012 2356 dbSNP
rs1489582730 2357 dbSNP
rs1255789417 2360 dbSNP
rs1045224272 2362 dbSNP
rs1483662390 2363 dbSNP
rs775086119 2364 dbSNP
rs917985792 2368 dbSNP
rs1409805793 2370 dbSNP
rs4388434 2377 dbSNP
rs1225596019 2382 dbSNP
rs1317373053 2386 dbSNP
rs1358694830 2392 dbSNP
rs1278962120 2397 dbSNP
rs935330735 2403 dbSNP
rs1435391974 2406 dbSNP
rs990896660 2407 dbSNP
rs925308625 2410 dbSNP
rs1353512215 2419 dbSNP
rs958954196 2425 dbSNP
rs978697296 2429 dbSNP
rs886063126 2430 dbSNP
rs1000343972 2442 dbSNP
rs76770837 2443 dbSNP
rs910476191 2445 dbSNP
rs73242165 2446 dbSNP
rs774452668 2455 dbSNP
rs1461205423 2456 dbSNP
rs1030024946 2462 dbSNP
rs886063125 2466 dbSNP
rs1482527688 2467 dbSNP
rs1172216376 2477 dbSNP
rs1205358016 2484 dbSNP
rs1479065793 2490 dbSNP
rs1234453465 2494 dbSNP
rs1416340691 2499 dbSNP
rs972258214 2500 dbSNP
rs961735408 2506 dbSNP
rs1175601346 2512 dbSNP
rs1041015238 2513 dbSNP
rs1429411504 2514 dbSNP
rs886063124 2518 dbSNP
rs1005895700 2519 dbSNP
rs1229656823 2523 dbSNP
rs1457522964 2527 dbSNP
rs1048812814 2532 dbSNP
rs1274583583 2544 dbSNP
rs1258739937 2547 dbSNP
rs116215385 2554 dbSNP
rs1294787664 2560 dbSNP
rs1340827433 2563 dbSNP
rs1214837747 2566 dbSNP
rs1274648264 2567 dbSNP
rs1023913668 2570 dbSNP
rs918451824 2573 dbSNP
rs972452184 2575 dbSNP
rs771039967 2577 dbSNP
rs1448912544 2586 dbSNP
rs531154046 2595 dbSNP
rs1052511287 2597 dbSNP
rs935451057 2598 dbSNP
rs917668890 2611 dbSNP
rs990473222 2612 dbSNP
rs1342008042 2620 dbSNP
rs903939367 2625 dbSNP
rs1319126794 2640 dbSNP
rs769903002 2645 dbSNP
rs959318247 2652 dbSNP
rs745430872 2654 dbSNP
rs28435921 2663 dbSNP
rs1271388908 2668 dbSNP
rs1377221867 2672 dbSNP
rs1353824652 2675 dbSNP
rs1332716242 2678 dbSNP
rs376903707 2680 dbSNP
rs1273641006 2690 dbSNP
rs910445135 2705 dbSNP
rs1020504494 2709 dbSNP
rs1447465214 2710 dbSNP
rs1194034158 2714 dbSNP
rs777973215 2716 dbSNP
rs1471941336 2729 dbSNP
rs1010416882 2731 dbSNP
rs1419117376 2733 dbSNP
rs965462901 2736 dbSNP
rs1393171186 2741 dbSNP
rs769852176 2742 dbSNP
rs986040433 2743 dbSNP
rs1458903705 2744 dbSNP
rs1319729485 2749 dbSNP
rs1370542221 2755 dbSNP
rs182677270 2761 dbSNP
rs889811144 2766 dbSNP
rs933147335 2770 dbSNP
rs533505766 2775 dbSNP
rs559780786 2779 dbSNP
rs1226373731 2784 dbSNP
rs748407306 2786 dbSNP
rs886063123 2787 dbSNP
rs995420455 2789 dbSNP
rs962066479 2790 dbSNP
rs1016029431 2793 dbSNP
rs897077925 2801 dbSNP
rs1440768596 2805 dbSNP
rs984842275 2806 dbSNP
rs1036793147 2815 dbSNP
rs969068964 2819 dbSNP
rs1476286838 2820 dbSNP
rs1023877731 2835 dbSNP
rs541441868 2837 dbSNP
rs896651966 2839 dbSNP
rs781372258 2841 dbSNP
rs1363523751 2845 dbSNP
rs1454813693 2847 dbSNP
rs1160791928 2851 dbSNP
rs772450201 2852 dbSNP
rs1399478993 2854 dbSNP
rs1413382904 2861 dbSNP
rs1312906621 2867 dbSNP
rs375955921 2868 dbSNP
rs573037096 2887 dbSNP
rs1357012788 2888 dbSNP
rs1407546255 2891 dbSNP
rs569387185 2894 dbSNP
rs1336115135 2901 dbSNP
rs1210335420 2903 dbSNP
rs1358403734 2911 dbSNP
rs1055308473 2914 dbSNP
rs1343021835 2922 dbSNP
rs746335104 2923 dbSNP
rs1281042658 2930 dbSNP
rs1486783516 2931 dbSNP
rs1203264796 2935 dbSNP
rs903906359 2940 dbSNP
rs190486993 2945 dbSNP
rs1250332252 2952 dbSNP
rs187371162 2961 dbSNP
rs924975411 2963 dbSNP
rs751974703 2973 dbSNP
rs1239164565 2982 dbSNP
rs1173725467 2985 dbSNP
rs1377108688 2991 dbSNP
rs771171156 2998 dbSNP
rs1438341891 3004 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000357039.4 | 3UTR | UUGGCUUUAUAUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000357039.4 | 3UTR | UUGGCUUUAUAUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
60 hsa-miR-4318 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT068761 RB1 RB transcriptional corepressor 1 2 2
MIRT094193 THAP6 THAP domain containing 6 2 2
MIRT166771 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT185495 SRP9 signal recognition particle 9 2 2
MIRT347687 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT441948 PEX2 peroxisomal biogenesis factor 2 2 2
MIRT443293 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT447126 DUSP16 dual specificity phosphatase 16 2 2
MIRT447428 MED21 mediator complex subunit 21 2 2
MIRT447971 MSH6 mutS homolog 6 2 2
MIRT450693 RPN2 ribophorin II 2 2
MIRT465671 TNPO2 transportin 2 2 2
MIRT477011 FAM60A SIN3-HDAC complex associated factor 2 2
MIRT479898 CCDC117 coiled-coil domain containing 117 2 2
MIRT488681 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT490349 PEX10 peroxisomal biogenesis factor 10 2 2
MIRT491108 NARS asparaginyl-tRNA synthetase 2 2
MIRT494804 ALG9 ALG9, alpha-1,2-mannosyltransferase 2 2
MIRT512730 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT518098 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 4
MIRT518113 RPS7 ribosomal protein S7 2 2
MIRT528967 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT529796 AP4S1 adaptor related protein complex 4 sigma 1 subunit 2 2
MIRT530503 FADS6 fatty acid desaturase 6 2 2
MIRT530797 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT532654 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT533417 TXLNG taxilin gamma 2 2
MIRT536327 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT537611 ERMP1 endoplasmic reticulum metallopeptidase 1 2 2
MIRT540738 FN3KRP fructosamine 3 kinase related protein 2 2
MIRT545780 ZNF805 zinc finger protein 805 2 2
MIRT549884 GINS4 GINS complex subunit 4 2 2
MIRT550618 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT551451 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT554858 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556558 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT572893 ADCY2 adenylate cyclase 2 2 2
MIRT576517 Slc35e2 solute carrier family 35, member E2 2 2
MIRT609005 PYGO1 pygopus family PHD finger 1 2 2
MIRT614782 SEC63 SEC63 homolog, protein translocation regulator 2 2
MIRT633849 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT634841 APOOL apolipoprotein O like 2 2
MIRT638838 CRTAP cartilage associated protein 2 2
MIRT639980 POU5F1B POU class 5 homeobox 1B 2 2
MIRT640263 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT641538 SNW1 SNW domain containing 1 2 2
MIRT656540 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT667590 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667732 KIAA1456 KIAA1456 2 2
MIRT667911 ING1 inhibitor of growth family member 1 2 2
MIRT669865 BROX BRO1 domain and CAAX motif containing 2 4
MIRT675877 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT676868 ZNF451 zinc finger protein 451 2 2
MIRT683211 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT704515 COL4A1 collagen type IV alpha 1 chain 2 2
MIRT710184 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT712036 TRIP13 thyroid hormone receptor interactor 13 2 2
MIRT716586 BRAP BRCA1 associated protein 2 2
MIRT724189 MMP16 matrix metallopeptidase 16 2 2
MIRT724205 MED7 mediator complex subunit 7 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4318 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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