miRTarBase - #MIRT442570


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pre-miRNA Information
pre-miRNA hsa-mir-7161   
Genomic Coordinates chr6: 158609707 - 158609790
Description Homo sapiens miR-7161 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-7161-5p
Sequence 1| UAAAGACUGUAGAGGCAACUGGU |23
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1198027002 1 dbSNP
rs530077902 10 dbSNP
rs1446817450 13 dbSNP
rs774892048 14 dbSNP
rs1438482648 16 dbSNP
rs1167166990 19 dbSNP
rs760372681 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CCDC59   
Synonyms BR22, HSPC128, TAP26
Description coiled-coil domain containing 59
Transcript NM_014167   
Expression
Putative miRNA Targets on CCDC59
3'UTR of CCDC59
(miRNA target sites are highlighted)		 
>CCDC59|NM_014167|3'UTR
   1 ACATTTTGTTCCTACAGGTTAAAATATCTGCTGCCTATTAGGTTCTTCTGTGACATGTGCCTCCCAGCAGTGAACTAAAT
  81 TTGTCGACATAAACTGGATTGCTAAACTATGCTAAATATAAGATGTTCACATATTTTTATTATGGTAAAAAATTTTCTAA
 161 ATATGTTCTACATGTTTCTTATTTATTTGCCTCTGAAGGAAGGTTGGCCTGAAGAACTGAAAGAACCTCTTATTTTGCAA
 241 GACAGGCCCAAGCATGTAATACTTTTGTACCATATGAGATTTATATGAAATAAATTTTTTAAAAATAAGGAATCAGAGCT
 321 ATCAATGAAGCATTTCAATGAAATATTTCAATTTAGTAAACAGTTACGTTGTTTTAAAATTTATTTTAATGATGAGGGAG
 401 GCAAAGACTCCTCTTGGACTTTTTATTTATTTTAAGTACATGTTACAGGGTGATGGGTGCTGAAATAAACTGCCCTCACC
 481 ATATAACAAAGCGACCTTCACAAAGCAGTGAACTCAAAGTCTGATATTTATAAACATTCCCTTAAATGGATGTACATGGC
 561 TTGTTAGTCTAAGGTCTTTTAAATAATGATGGAAACCCCACAGTGTCACAGCAAGAATTAAGCTTTCCAGTTCCTATGGA
 641 CCCTATACTTTAAGAACATTATCTCTGTCTCCCTTGTTGGTACCCTTGTGAGCTGAGATAAGCCACTGGGATAACTGCTT
 721 CTCATGCTTTGCAAATTGCAGAAGAATGAGAAAGGCTTGAAATATATATATAGTCATTGTAAGCAAAAAGGGCTGACCAA
 801 TAATACTTGCCAAATATTGAATAATAAAATTTTATAAATGATAGCAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uggucAACGG--AGAUGUCAGAAAu 5'
               |||::  |||| :|||||| 
Target 5' atggcTTGTTAGTCTAAGGTCTTTt 3'
 556 - 580 148.00 -11.90
2 
miRNA  3' uggucaacggAGAUGUCAGAAAu 5'
                    | ||:|||| || 
Target 5' ttgaaatataTATATAGTCATTg 3'
 757 - 779 121.00 -6.30
3 
miRNA  3' ugGUCAACGGAGAUGUCAGAaau 5'
            ||||   ||| | |||||   
Target 5' agCAGTGAACTC-AAAGTCTgat 3'
 504 - 525 120.00 -13.02
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30162991 7 COSMIC
COSN26969529 29 COSMIC
COSN28891047 30 COSMIC
COSN15668231 33 COSMIC
COSN30532768 53 COSMIC
COSN31504138 54 COSMIC
COSN30498337 57 COSMIC
COSN16121124 85 COSMIC
COSN30178901 130 COSMIC
COSN30115182 150 COSMIC
COSN31602245 151 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1358572205 9 dbSNP
rs368318331 10 dbSNP
rs1244008715 11 dbSNP
rs757984233 14 dbSNP
rs1333077458 16 dbSNP
rs750304229 17 dbSNP
rs765259086 25 dbSNP
rs761873699 27 dbSNP
rs1198182804 30 dbSNP
rs765569828 37 dbSNP
rs753639402 39 dbSNP
rs1173254123 40 dbSNP
rs1411035014 41 dbSNP
rs376823050 42 dbSNP
rs1472744301 43 dbSNP
rs1409553762 48 dbSNP
rs781255142 49 dbSNP
rs928204496 50 dbSNP
rs577119264 55 dbSNP
rs576461878 59 dbSNP
rs981806780 62 dbSNP
rs1290334826 69 dbSNP
rs1014752295 70 dbSNP
rs185232815 80 dbSNP
rs1344317105 85 dbSNP
rs947708832 86 dbSNP
rs757403456 88 dbSNP
rs1464625420 94 dbSNP
rs1173018604 98 dbSNP
rs1376294677 108 dbSNP
rs1416921782 109 dbSNP
rs1306384875 111 dbSNP
rs983126700 112 dbSNP
rs916209939 114 dbSNP
rs951839989 115 dbSNP
rs1156708531 118 dbSNP
rs751558373 119 dbSNP
rs1436456497 127 dbSNP
rs973166093 128 dbSNP
rs539941894 130 dbSNP
rs963093957 131 dbSNP
rs1014786053 133 dbSNP
rs1193058827 139 dbSNP
rs1011930780 143 dbSNP
rs577866823 151 dbSNP
rs983668951 152 dbSNP
rs14568 160 dbSNP
rs1177516039 170 dbSNP
rs1252590402 179 dbSNP
rs1431301462 181 dbSNP
rs569120081 182 dbSNP
rs764689030 198 dbSNP
rs1030673580 202 dbSNP
rs1436628714 203 dbSNP
rs1166983650 207 dbSNP
rs1354107569 215 dbSNP
rs1462830045 217 dbSNP
rs1300198485 232 dbSNP
rs758925643 237 dbSNP
rs1440898498 246 dbSNP
rs1485666278 247 dbSNP
rs146222686 248 dbSNP
rs1304774744 249 dbSNP
rs1371140356 255 dbSNP
rs1235796723 257 dbSNP
rs753124502 262 dbSNP
rs112398991 265 dbSNP
rs1204960992 267 dbSNP
rs1042581438 275 dbSNP
rs1487371282 278 dbSNP
rs1212708188 281 dbSNP
rs946756672 285 dbSNP
rs1455657995 290 dbSNP
rs1186693367 294 dbSNP
rs1349201806 296 dbSNP
rs1419084532 299 dbSNP
rs893909848 300 dbSNP
rs1280286992 307 dbSNP
rs1050295126 310 dbSNP
rs1348549877 311 dbSNP
rs932657271 312 dbSNP
rs1327198018 321 dbSNP
rs535751634 322 dbSNP
rs181000629 325 dbSNP
rs376117871 331 dbSNP
rs77141800 337 dbSNP
rs759976275 345 dbSNP
rs1214853415 346 dbSNP
rs1382399402 351 dbSNP
rs1052657536 358 dbSNP
rs1000094447 361 dbSNP
rs528616310 367 dbSNP
rs1273753078 368 dbSNP
rs1469714255 374 dbSNP
rs369644403 380 dbSNP
rs1213557308 389 dbSNP
rs1241659812 389 dbSNP
rs4460873 400 dbSNP
rs564362653 418 dbSNP
rs1411843371 419 dbSNP
rs772977340 422 dbSNP
rs1046683796 423 dbSNP
rs948260840 425 dbSNP
rs1420658086 435 dbSNP
rs916260795 435 dbSNP
rs1318229143 436 dbSNP
rs551952324 437 dbSNP
rs539491209 441 dbSNP
rs1290289088 446 dbSNP
rs941811170 457 dbSNP
rs1293754880 458 dbSNP
rs983320508 460 dbSNP
rs907612690 462 dbSNP
rs983190199 468 dbSNP
rs79915959 474 dbSNP
rs1447683511 477 dbSNP
rs923085774 481 dbSNP
rs1255680150 484 dbSNP
rs1173001915 485 dbSNP
rs991004407 487 dbSNP
rs563118746 488 dbSNP
rs1471801043 490 dbSNP
rs372144305 492 dbSNP
rs1409295275 493 dbSNP
rs1171257052 510 dbSNP
rs189435146 512 dbSNP
rs959061175 518 dbSNP
rs1373094427 519 dbSNP
rs1413854410 519 dbSNP
rs574776419 520 dbSNP
rs964587552 521 dbSNP
rs1003757925 526 dbSNP
rs559644092 536 dbSNP
rs1439700281 537 dbSNP
rs10735453 550 dbSNP
rs1486241197 553 dbSNP
rs186597030 559 dbSNP
rs1278371005 577 dbSNP
rs1347226078 583 dbSNP
rs1209275735 585 dbSNP
rs777145104 588 dbSNP
rs1021104952 596 dbSNP
rs1011057286 599 dbSNP
rs558729034 602 dbSNP
rs1471482344 615 dbSNP
rs1192298729 623 dbSNP
rs768645266 626 dbSNP
rs1392777806 628 dbSNP
rs1306532199 629 dbSNP
rs539533863 635 dbSNP
rs1173910351 636 dbSNP
rs893995403 639 dbSNP
rs1010859250 643 dbSNP
rs35038681 644 dbSNP
rs1293084967 645 dbSNP
rs575721452 646 dbSNP
rs1336122855 648 dbSNP
rs1444362569 651 dbSNP
rs34902584 654 dbSNP
rs958183825 654 dbSNP
rs1301129925 658 dbSNP
rs1416383062 663 dbSNP
rs1235052346 666 dbSNP
rs1282757767 667 dbSNP
rs1049830086 668 dbSNP
rs997380791 670 dbSNP
rs1412812584 671 dbSNP
rs901144686 680 dbSNP
rs1398572124 684 dbSNP
rs1212414189 685 dbSNP
rs1031511822 688 dbSNP
rs141663769 692 dbSNP
rs1193646786 704 dbSNP
rs907812739 705 dbSNP
rs906712430 710 dbSNP
rs1474258351 720 dbSNP
rs1048129867 723 dbSNP
rs761426792 747 dbSNP
rs930478748 756 dbSNP
rs773698907 761 dbSNP
rs1323841860 764 dbSNP
rs535882184 765 dbSNP
rs920455485 768 dbSNP
rs1305807251 773 dbSNP
rs1324752154 773 dbSNP
rs895379551 778 dbSNP
rs1227037870 786 dbSNP
rs1270961877 795 dbSNP
rs1341952517 797 dbSNP
rs1475661330 800 dbSNP
rs990581572 802 dbSNP
rs1469246366 803 dbSNP
rs1216089777 810 dbSNP
rs959112503 811 dbSNP
rs1417542915 813 dbSNP
rs1192073437 817 dbSNP
rs1478689190 821 dbSNP
rs564522009 821 dbSNP
rs1162449719 826 dbSNP
rs148629531 828 dbSNP
rs74565458 831 dbSNP
rs1295198341 832 dbSNP
rs535002533 832 dbSNP
rs1381680067 834 dbSNP
rs1319258112 835 dbSNP
rs1047955361 836 dbSNP
rs966389824 837 dbSNP
rs143878269 838 dbSNP
rs552767780 849 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000256151.7 | 3UTR | UUGGCAAUAAAUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-7161-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT131193 INCENP inner centromere protein 2 4
MIRT318016 CENPQ centromere protein Q 2 2
MIRT405275 ZNF678 zinc finger protein 678 2 2
MIRT442570 CCDC59 coiled-coil domain containing 59 2 2
MIRT442611 CRIPT CXXC repeat containing interactor of PDZ3 domain 2 2
MIRT444013 GOLGA8H golgin A8 family member H 2 2
MIRT444024 GOLGA8M golgin A8 family member M 2 2
MIRT444339 GOLGA6L4 golgin A6 family-like 4 2 2
MIRT444611 GOLGA6L10 golgin A6 family-like 10 2 2
MIRT446342 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT446558 GOLGA8J golgin A8 family member J 2 2
MIRT447671 PACSIN2 protein kinase C and casein kinase substrate in neurons 2 2 2
MIRT447975 MSH6 mutS homolog 6 2 2
MIRT448895 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT448936 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT449414 TRIM5 tripartite motif containing 5 2 2
MIRT450291 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT454877 PCNA proliferating cell nuclear antigen 2 4
MIRT456615 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT462108 TMEM214 transmembrane protein 214 2 2
MIRT471923 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT474437 KLHL21 kelch like family member 21 2 2
MIRT476600 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT480573 BZW1 basic leucine zipper and W2 domains 1 2 2
MIRT483890 IL20RB interleukin 20 receptor subunit beta 2 6
MIRT493363 KIF5B kinesin family member 5B 2 2
MIRT494934 TMEM167A transmembrane protein 167A 2 2
MIRT495915 CLDN1 claudin 1 2 2
MIRT501574 PLEKHF2 pleckstrin homology and FYVE domain containing 2 2 4
MIRT502193 IGF1R insulin like growth factor 1 receptor 2 4
MIRT502928 CDC42SE1 CDC42 small effector 1 2 4
MIRT506393 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 4
MIRT506570 MNX1 motor neuron and pancreas homeobox 1 2 4
MIRT509478 GNL3L G protein nucleolar 3 like 2 6
MIRT518537 FLCN folliculin 2 6
MIRT519577 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT524088 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 4
MIRT524146 LDHD lactate dehydrogenase D 2 4
MIRT524659 C1orf50 chromosome 1 open reading frame 50 2 10
MIRT526324 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526566 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526612 ZNF780A zinc finger protein 780A 2 4
MIRT526889 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT527115 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT528023 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT529589 TMEM220 transmembrane protein 220 2 2
MIRT532797 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT537099 GPC6 glypican 6 2 2
MIRT539070 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 2
MIRT545495 DAPK2 death associated protein kinase 2 2 2
MIRT545814 ZNF608 zinc finger protein 608 2 4
MIRT553533 TMEM185B transmembrane protein 185B 2 4
MIRT557285 HIST2H2BE histone cluster 2 H2B family member e 2 2
MIRT559552 ARGLU1 arginine and glutamate rich 1 2 4
MIRT561069 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT561710 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT561995 LRRC58 leucine rich repeat containing 58 2 2
MIRT565896 NHS NHS actin remodeling regulator 2 2
MIRT567333 HMGB1 high mobility group box 1 2 2
MIRT568042 CLDN12 claudin 12 2 2
MIRT568315 BAG4 BCL2 associated athanogene 4 2 2
MIRT570677 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT571047 YRDC yrdC N6-threonylcarbamoyltransferase domain containing 2 2
MIRT571359 SFT2D2 SFT2 domain containing 2 2 2
MIRT571935 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT572786 ZNF277 zinc finger protein 277 2 2
MIRT573936 CNTNAP2 contactin associated protein like 2 2 2
MIRT576962 Anxa4 annexin A4 2 3
MIRT608297 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT613342 AFF1 AF4/FMR2 family member 1 2 2
MIRT613529 ANAPC7 anaphase promoting complex subunit 7 2 2
MIRT614705 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT616658 ORAI1 ORAI calcium release-activated calcium modulator 1 2 2
MIRT624731 ANXA4 annexin A4 2 3
MIRT626525 TSC1 TSC complex subunit 1 2 2
MIRT627647 SCN1A sodium voltage-gated channel alpha subunit 1 2 2
MIRT637423 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT641059 TCP11L1 t-complex 11 like 1 2 4
MIRT645591 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT646455 ZNF705A zinc finger protein 705A 2 2
MIRT656454 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT676551 TMPPE transmembrane protein with metallophosphoesterase domain 2 4
MIRT682720 KIAA1456 KIAA1456 2 2
MIRT698307 TMEM2 transmembrane protein 2 2 2
MIRT701906 MMGT1 membrane magnesium transporter 1 2 2
MIRT702228 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT708642 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT709326 HMBOX1 homeobox containing 1 2 2
MIRT711400 RANBP2 RAN binding protein 2 2 2
MIRT712130 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT714226 ARMC10 armadillo repeat containing 10 2 2
MIRT716914 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT723060 FGD6 FYVE, RhoGEF and PH domain containing 6 2 2
MIRT723846 MN1 MN1 proto-oncogene, transcriptional regulator 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-7161-5p Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (HEYA8)

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