miRTarBase - #MIRT442594


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pre-miRNA Information
pre-miRNA hsa-mir-3921   
Genomic Coordinates chr3: 99964314 - 99964398
Description Homo sapiens miR-3921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3921
Sequence 52| UCUCUGAGUACCAUAUGCCUUGU |74
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN7769671 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs758695096 5 dbSNP
rs539077798 6 dbSNP
rs954620527 10 dbSNP
rs1437951547 17 dbSNP
Putative Targets

Gene Information
Gene Symbol SIX1   
Synonyms BOS3, DFNA23, TIP39
Description SIX homeobox 1
Transcript NM_005982   
Expression
Putative miRNA Targets on SIX1
3'UTR of SIX1
(miRNA target sites are highlighted)		 
>SIX1|NM_005982|3'UTR
   1 GTGGGGAGGGACTGGGGCCTCGAAGGGATTCCTGGAGCAGCAACCACTGCAGCGACTAGGGACACTTGTAAATAGAAATC
  81 AGGAACATTTTTGCAGCTTGTTTCTGGAGTTGTTTGCGCATAAAGGAATGGTGGACTTTCACAAATATCTTTTTAAAAAT
 161 CAAAACCAACAGCGATCTCAAGCTTAATCTCCTCTTCTCTCCAACTCTTTCCACTTTTGCATTTTCCTTCCCAATGCAGA
 241 GATCAGGGAAAAAAAAAAAAAAAAACCCAAACAAACAAAAGCACCCAGGCACCCAGTCTGAGTTCTGGGCAACTGATACG
 321 CCTGTTTCAGCAGCCTTTCTTTTTTTTCAATGAATGGGAATTGCAAATCAACTGGATTTTCATTATTTCCTTTTAATTTA
 401 TATATGGAGAAATGTGAAGAGGGAAAGGAAATGGAAAGAGAAAGAGAAAGGGAGATAAAAATAGTGAAAATAAGAGCCTC
 481 CAGGCTCAGAAGAACTGATTACATTCTTAAGGTGAACAGGAAAAATACAATCTATAACTTTCTTTGATGAGGAAAAATTA
 561 AGTTTACATTTTTCATATTTAGTGTTAAACAATTTAATGTAGATTAAAATAAAAGACCAGTATTAGGAGGAAAAAACAAG
 641 TGCCTAAATGTCTTAATGCTCTCTATGTGAGACAGAAATAGACGTGACCATTAGTAATGCAACTATTTTTGTCAAATTTA
 721 GTGGGATTTTTTGGTTGTTGTTTGTTTTCTTGGGTTTTTTTTTTTTAAATGACAAACTCTAAAAATGTACCAATGTGAAA
 801 AAACACTTTCCTGAATGCCATTACTCATGCCCTCAAAGCTTTCATATCTGTAGCCTACTCCTGTAAAGGGTTTCTCCTGT
 881 TTCTAGTTTCTAGTTTGCAAAGGTATGCCAACGAATCTGGCAACCTGGTATTTGTTACTAAAACAGCATGTGTTTTCAGG
 961 TTTCTTTTCTATTGTACCTAAAGCAGTCTAAATTAAAACTTAGTAGAACACCAGGAGTATGATTCTGTTTCTGAAAGGTG
1041 AGTGGTGTATTGCTGTCATTGGGCCCTATTTTTTTTTTTAAATATATTTTTCTTTCTTACTTAATGGTGGCTGTGAATTG
1121 CAGGGTACTTTGAAGGCCATCATCTGAACCAAGAGTAGTAACTAGATTAATTATATGACAGAAAGAGTGAATTTAGCCTT
1201 GGGGTATTTATTAACTTCTATTATTTAGATATGCAATTTTGTTTACCACTATCTCTTCACAGCATTCATATGTTAACTAA
1281 GCTCTTTTGTGTTAACAAGTTTATGACAAGACTGTGAAAGTAAAAATAATTTATCTGCTTGAAGACAAAAAAGGGAAGGA
1361 GAACAAGGATAGAAACATTGTGAATTAATTTGTACAAATAGAAAGCAGACCAGCAGGACAGGAGCTCTTTTGCAGTGCTG
1441 CCGGATGGTGTCTAGAAAAATCCCAGTAATCATGTAGGCTCCATATTATTTTTGCCTGGGGCAAAATGATGTATCTTCTG
1521 TATTTAGCTTTTAAAATTAGTGAAACAAATGGCATTATTTATTAAAATTCTACTCAGGATAACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUUC-CGUAUACCAUGAGUCUcu 5'
            ||| || |   | :||||||  
Target 5' atAAGAGCCTCCAG-GCTCAGAag 3'
 470 - 492 128.00 -11.62
2 
miRNA  3' uguuccgUAUACCAUGAGUCUcu 5'
                 | ||  |||||||:  
Target 5' tttattaAAATTCTACTCAGGat 3'
 1558 - 1580 120.00 -8.40
3 
miRNA  3' uguucCGUAUACCAUGAGUCUcu 5'
               ||||:| || :||||:  
Target 5' aaacaGCATGT-GTTTTCAGGtt 3'
 941 - 962 113.00 -13.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
883290 140 ClinVar
313463 161 ClinVar
883289 249 ClinVar
1188527 266 ClinVar
313462 266 ClinVar
883288 266 ClinVar
313461 280 ClinVar
313460 297 ClinVar
313459 334 ClinVar
313458 371 ClinVar
313457 404 ClinVar
313456 443 ClinVar
313455 582 ClinVar
313454 602 ClinVar
880739 688 ClinVar
313453 736 ClinVar
313452 755 ClinVar
884035 766 ClinVar
313449 767 ClinVar
313450 767 ClinVar
313451 767 ClinVar
883235 858 ClinVar
313448 897 ClinVar
313447 1001 ClinVar
313446 1009 ClinVar
313445 1044 ClinVar
313444 1079 ClinVar
882090 1080 ClinVar
882089 1232 ClinVar
882088 1251 ClinVar
313443 1272 ClinVar
313442 1496 ClinVar
313441 1571 ClinVar
COSN30491136 3 COSMIC
COSN30128753 10 COSMIC
COSN30102631 22 COSMIC
COSN30489268 31 COSMIC
COSN31493304 52 COSMIC
COSN17840702 59 COSMIC
COSN26994771 63 COSMIC
COSN31516080 75 COSMIC
COSN31537637 118 COSMIC
COSN1655838 191 COSMIC
COSN20078085 213 COSMIC
COSN20111367 249 COSMIC
COSN20111371 249 COSMIC
COSN18723543 250 COSMIC
COSN229313 460 COSMIC
COSN14469782 652 COSMIC
COSN14469365 659 COSMIC
COSN14471733 661 COSMIC
COSN14472216 713 COSMIC
COSN14469816 749 COSMIC
COSN27623250 752 COSMIC
COSN20111363 755 COSMIC
COSN14470636 779 COSMIC
COSN8846719 912 COSMIC
COSN30417120 1002 COSMIC
COSN28834387 1070 COSMIC
COSN28834498 1181 COSMIC
COSN26608674 1620 COSMIC
COSN30194815 1713 COSMIC
COSN26694487 1874 COSMIC
COSN8846718 1982 COSMIC
COSN23735379 2006 COSMIC
COSN26032412 2147 COSMIC
COSN29360736 2638 COSMIC
COSN27313981 2848 COSMIC
COSN28922687 2849 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1016053107 1 dbSNP
rs1352247410 2 dbSNP
rs746321314 3 dbSNP
rs771392443 4 dbSNP
rs1324023369 5 dbSNP
rs1484648132 13 dbSNP
rs1311076435 15 dbSNP
rs1395785407 18 dbSNP
rs1362945865 21 dbSNP
rs374399275 22 dbSNP
rs778176231 24 dbSNP
rs754609676 31 dbSNP
rs751226156 33 dbSNP
rs779363054 49 dbSNP
rs757953542 50 dbSNP
rs769635996 54 dbSNP
rs373673863 62 dbSNP
rs1347222218 66 dbSNP
rs1263397943 93 dbSNP
rs916678185 93 dbSNP
rs1056620896 114 dbSNP
rs1310094321 115 dbSNP
rs1023250770 117 dbSNP
rs1013155666 118 dbSNP
rs1389699235 120 dbSNP
rs896042239 122 dbSNP
rs918820750 138 dbSNP
rs1348429370 140 dbSNP
rs113680815 144 dbSNP
rs1298159023 149 dbSNP
rs886050571 161 dbSNP
rs751366842 165 dbSNP
rs1391435674 166 dbSNP
rs766323925 168 dbSNP
rs1433616495 170 dbSNP
rs1296212818 172 dbSNP
rs568572700 173 dbSNP
rs1310180477 174 dbSNP
rs548655754 179 dbSNP
rs1377722386 180 dbSNP
rs576067443 189 dbSNP
rs1269827031 194 dbSNP
rs1463484813 197 dbSNP
rs1433731573 201 dbSNP
rs946416352 201 dbSNP
rs1380307135 204 dbSNP
rs367844913 206 dbSNP
rs962011450 211 dbSNP
rs893455823 214 dbSNP
rs908849819 217 dbSNP
rs1417184004 222 dbSNP
rs1411874956 233 dbSNP
rs1407133681 236 dbSNP
rs1423504347 237 dbSNP
rs1182416305 239 dbSNP
rs1484108960 241 dbSNP
rs1255208969 243 dbSNP
rs1208924578 244 dbSNP
rs1414728098 245 dbSNP
rs61991660 246 dbSNP
rs1456059194 249 dbSNP
rs867880214 249 dbSNP
rs1286772936 250 dbSNP
rs1359194840 250 dbSNP
rs984435706 259 dbSNP
rs1377947902 260 dbSNP
rs1410123025 261 dbSNP
rs1289966889 262 dbSNP
rs1326829742 263 dbSNP
rs1315246090 264 dbSNP
rs80194537 265 dbSNP
rs1049363176 266 dbSNP
rs112733948 266 dbSNP
rs1279277557 266 dbSNP
rs1313935065 266 dbSNP
rs1491116498 266 dbSNP
rs766038211 266 dbSNP
rs869276383 266 dbSNP
rs1491335020 267 dbSNP
rs1229455831 269 dbSNP
rs1471833431 272 dbSNP
rs1159014894 275 dbSNP
rs986710111 276 dbSNP
rs185694350 278 dbSNP
rs886050570 280 dbSNP
rs1173336100 284 dbSNP
rs1358128302 285 dbSNP
rs965942520 286 dbSNP
rs1309477905 297 dbSNP
rs147081368 297 dbSNP
rs1408973632 298 dbSNP
rs1275268955 301 dbSNP
rs1381218801 305 dbSNP
rs976613412 313 dbSNP
rs1347252482 319 dbSNP
rs879084294 319 dbSNP
rs1206089028 320 dbSNP
rs1277065481 320 dbSNP
rs1413744932 321 dbSNP
rs1360791703 324 dbSNP
rs1181496602 328 dbSNP
rs1290315275 331 dbSNP
rs10144415 334 dbSNP
rs1189992880 339 dbSNP
rs1022274842 343 dbSNP
rs908658203 347 dbSNP
rs1344157919 348 dbSNP
rs1012269705 350 dbSNP
rs895211253 357 dbSNP
rs984599493 359 dbSNP
rs952712736 362 dbSNP
rs915931771 363 dbSNP
rs182923762 365 dbSNP
rs1344923456 368 dbSNP
rs538935374 371 dbSNP
rs991454260 402 dbSNP
rs191393983 403 dbSNP
rs76116881 404 dbSNP
rs1370274370 410 dbSNP
rs999067967 419 dbSNP
rs1264137607 427 dbSNP
rs186530769 443 dbSNP
rs910154027 451 dbSNP
rs1195501857 461 dbSNP
rs1260235992 463 dbSNP
rs1453685876 464 dbSNP
rs1219952724 465 dbSNP
rs527420447 469 dbSNP
rs1252942007 478 dbSNP
rs564879010 480 dbSNP
rs57517528 489 dbSNP
rs1450683673 498 dbSNP
rs1189941638 502 dbSNP
rs984402964 509 dbSNP
rs1448445916 511 dbSNP
rs544567737 513 dbSNP
rs921680501 515 dbSNP
rs975898177 532 dbSNP
rs1389247170 541 dbSNP
rs1437274409 542 dbSNP
rs1010631639 546 dbSNP
rs1322625216 546 dbSNP
rs1226882950 550 dbSNP
rs1233033383 562 dbSNP
rs966192118 565 dbSNP
rs893527067 581 dbSNP
rs556041829 582 dbSNP
rs1273026393 588 dbSNP
rs1465737404 593 dbSNP
rs1049391881 599 dbSNP
rs1245598377 601 dbSNP
rs78909843 602 dbSNP
rs557193382 610 dbSNP
rs1012240423 615 dbSNP
rs1157411338 616 dbSNP
rs1293606022 616 dbSNP
rs901127505 625 dbSNP
rs1163941130 637 dbSNP
rs1412512467 637 dbSNP
rs1458693459 646 dbSNP
rs1041351055 650 dbSNP
rs1156862293 652 dbSNP
rs776796977 655 dbSNP
rs180814298 659 dbSNP
rs1035511839 661 dbSNP
rs1003590047 665 dbSNP
rs1293005022 679 dbSNP
rs1462908925 683 dbSNP
rs1392224040 684 dbSNP
rs1266809909 688 dbSNP
rs1164180111 689 dbSNP
rs1465946034 698 dbSNP
rs1374643924 701 dbSNP
rs1350649556 703 dbSNP
rs908352267 709 dbSNP
rs751939659 711 dbSNP
rs1440323008 716 dbSNP
rs1186796651 721 dbSNP
rs1048233246 725 dbSNP
rs781319339 733 dbSNP
rs768828257 736 dbSNP
rs1469917275 738 dbSNP
rs1156795162 740 dbSNP
rs1251644307 743 dbSNP
rs1381220119 747 dbSNP
rs1037180214 748 dbSNP
rs1466522200 748 dbSNP
rs915959668 754 dbSNP
rs868568764 755 dbSNP
rs941556038 755 dbSNP
rs1312534885 765 dbSNP
rs63554860 766 dbSNP
rs1234676082 767 dbSNP
rs1412039041 767 dbSNP
rs33943216 767 dbSNP
rs574976629 767 dbSNP
rs886050569 767 dbSNP
rs199935032 768 dbSNP
rs201192478 770 dbSNP
rs1301294459 774 dbSNP
rs1274932721 777 dbSNP
rs1442433610 785 dbSNP
rs1179707997 789 dbSNP
rs1249634367 792 dbSNP
rs1433646746 794 dbSNP
rs1368241949 804 dbSNP
rs1379408797 804 dbSNP
rs1452685529 812 dbSNP
rs928933591 816 dbSNP
rs1173148176 822 dbSNP
rs1371367195 826 dbSNP
rs554892433 827 dbSNP
rs1325127797 829 dbSNP
rs921564068 831 dbSNP
rs189312189 839 dbSNP
rs1396242161 843 dbSNP
rs967633223 850 dbSNP
rs1304090058 857 dbSNP
rs1447444602 860 dbSNP
rs1022225332 864 dbSNP
rs1232894119 868 dbSNP
rs370867168 882 dbSNP
rs1398283247 883 dbSNP
rs561797428 897 dbSNP
rs1011665214 898 dbSNP
rs923702534 903 dbSNP
rs957784827 911 dbSNP
rs1028024102 913 dbSNP
rs1383479634 914 dbSNP
rs1250487170 917 dbSNP
rs1174540893 924 dbSNP
rs1488705273 937 dbSNP
rs1211517512 947 dbSNP
rs1265157948 971 dbSNP
rs1455638899 972 dbSNP
rs996500459 982 dbSNP
rs900821001 993 dbSNP
rs1390930285 999 dbSNP
rs1451496755 1000 dbSNP
rs886050568 1001 dbSNP
rs1168604181 1002 dbSNP
rs1372825993 1004 dbSNP
rs1040990738 1006 dbSNP
rs977930991 1008 dbSNP
rs148821608 1009 dbSNP
rs915153531 1013 dbSNP
rs1440902479 1035 dbSNP
rs1193494251 1043 dbSNP
rs1320620604 1044 dbSNP
rs3742637 1044 dbSNP
rs990775062 1052 dbSNP
rs959277901 1067 dbSNP
rs1294438277 1069 dbSNP
rs1322001454 1072 dbSNP
rs887000811 1075 dbSNP
rs559116477 1079 dbSNP
rs1003972129 1080 dbSNP
rs1209290459 1080 dbSNP
rs931132506 1080 dbSNP
rs186149844 1092 dbSNP
rs1016123185 1095 dbSNP
rs1261265515 1098 dbSNP
rs1005667776 1104 dbSNP
rs1167340769 1107 dbSNP
rs1416216229 1109 dbSNP
rs1461321396 1113 dbSNP
rs3742638 1120 dbSNP
rs1390145827 1128 dbSNP
rs1428017819 1129 dbSNP
rs747274676 1133 dbSNP
rs1259861901 1134 dbSNP
rs1379440731 1140 dbSNP
rs1055876445 1142 dbSNP
rs1291150699 1155 dbSNP
rs888656744 1158 dbSNP
rs938722386 1161 dbSNP
rs1049888091 1166 dbSNP
rs1269964910 1176 dbSNP
rs1327055966 1186 dbSNP
rs1241662863 1187 dbSNP
rs997021988 1187 dbSNP
rs780378618 1196 dbSNP
rs1040014700 1197 dbSNP
rs1255803815 1204 dbSNP
rs1475099815 1214 dbSNP
rs181833190 1215 dbSNP
rs1414794767 1220 dbSNP
rs1399537579 1223 dbSNP
rs1157717881 1224 dbSNP
rs1345048636 1229 dbSNP
rs558532789 1232 dbSNP
rs914785412 1240 dbSNP
rs1310726091 1241 dbSNP
rs1354531799 1243 dbSNP
rs1042563695 1249 dbSNP
rs746385772 1251 dbSNP
rs915036970 1265 dbSNP
rs990659039 1267 dbSNP
rs1283573331 1268 dbSNP
rs1312883749 1271 dbSNP
rs3832952 1272 dbSNP
rs779226095 1283 dbSNP
rs1485493296 1284 dbSNP
rs757802086 1284 dbSNP
rs1028056922 1306 dbSNP
rs1469003464 1316 dbSNP
rs982122567 1319 dbSNP
rs1425205566 1327 dbSNP
rs1434418291 1335 dbSNP
rs550089904 1338 dbSNP
rs536496013 1339 dbSNP
rs1430078380 1343 dbSNP
rs1005556303 1344 dbSNP
rs965132403 1347 dbSNP
rs952808390 1349 dbSNP
rs1275392329 1358 dbSNP
rs1402729542 1365 dbSNP
rs137994957 1376 dbSNP
rs1236552152 1391 dbSNP
rs1003844969 1392 dbSNP
rs1436828760 1406 dbSNP
rs1229431242 1409 dbSNP
rs1275476885 1411 dbSNP
rs1393274599 1414 dbSNP
rs1173122510 1417 dbSNP
rs1436459721 1421 dbSNP
rs1470769347 1423 dbSNP
rs1366031440 1424 dbSNP
rs1247777402 1431 dbSNP
rs887064797 1435 dbSNP
rs1191197055 1436 dbSNP
rs1180332577 1445 dbSNP
rs1394009814 1461 dbSNP
rs1449634732 1464 dbSNP
rs1170097563 1473 dbSNP
rs996987391 1475 dbSNP
rs901405689 1477 dbSNP
rs146967331 1478 dbSNP
rs1008554191 1481 dbSNP
rs995368945 1483 dbSNP
rs1438697148 1485 dbSNP
rs1323905597 1494 dbSNP
rs1370346948 1495 dbSNP
rs61993831 1496 dbSNP
rs1272165482 1507 dbSNP
rs1055614826 1508 dbSNP
rs1212495259 1511 dbSNP
rs946413885 1515 dbSNP
rs569954956 1516 dbSNP
rs547309317 1518 dbSNP
rs1214318211 1519 dbSNP
rs140088005 1523 dbSNP
rs1337562828 1533 dbSNP
rs1205184550 1549 dbSNP
rs1352267331 1552 dbSNP
rs1212377432 1557 dbSNP
rs1251759758 1559 dbSNP
rs907252831 1561 dbSNP
rs1464980060 1562 dbSNP
rs1042111674 1563 dbSNP
rs1054948020 1570 dbSNP
rs886050567 1571 dbSNP
rs564608572 1578 dbSNP
rs1239976491 1591 dbSNP
rs780886440 1598 dbSNP
rs1163613445 1604 dbSNP
rs1415711921 1605 dbSNP
rs914857423 1613 dbSNP
rs990347235 1614 dbSNP
rs1459750930 1626 dbSNP
rs932174899 1628 dbSNP
rs1294905037 1634 dbSNP
rs369652458 1642 dbSNP
rs544714667 1642 dbSNP
rs549651007 1642 dbSNP
rs1373890525 1651 dbSNP
rs1320411595 1652 dbSNP
rs754653439 1662 dbSNP
rs927895868 1666 dbSNP
rs976248538 1668 dbSNP
rs1357761129 1673 dbSNP
rs1231951364 1674 dbSNP
rs908506374 1675 dbSNP
rs939958393 1675 dbSNP
rs1206379089 1681 dbSNP
rs984100389 1685 dbSNP
rs1446004416 1700 dbSNP
rs1187821093 1704 dbSNP
rs1259307694 1705 dbSNP
rs1474117131 1706 dbSNP
rs1187017170 1707 dbSNP
rs1401322337 1708 dbSNP
rs536482741 1710 dbSNP
rs1455342948 1711 dbSNP
rs1019357898 1714 dbSNP
rs982889942 1715 dbSNP
rs1400269283 1716 dbSNP
rs951014820 1720 dbSNP
rs1026927518 1722 dbSNP
rs1357701344 1737 dbSNP
rs1413292841 1761 dbSNP
rs1293137728 1763 dbSNP
rs1418983464 1765 dbSNP
rs1351631970 1768 dbSNP
rs995442760 1769 dbSNP
rs562192751 1770 dbSNP
rs869147380 1775 dbSNP
rs72533332 1776 dbSNP
rs35172688 1777 dbSNP
rs10689648 1778 dbSNP
rs202221147 1778 dbSNP
rs397735355 1778 dbSNP
rs1484507846 1781 dbSNP
rs201073444 1781 dbSNP
rs1209882229 1793 dbSNP
rs894369079 1796 dbSNP
rs1252342536 1806 dbSNP
rs1034194309 1818 dbSNP
rs1179575380 1828 dbSNP
rs1362091033 1839 dbSNP
rs1469710036 1845 dbSNP
rs1174385465 1856 dbSNP
rs1193540468 1859 dbSNP
rs1377499932 1859 dbSNP
rs141145133 1868 dbSNP
rs774930182 1868 dbSNP
rs1002672851 1869 dbSNP
rs1281542564 1872 dbSNP
rs1204409900 1873 dbSNP
rs1397666706 1878 dbSNP
rs1393610042 1879 dbSNP
rs1327465165 1880 dbSNP
rs907317915 1887 dbSNP
rs999472976 1906 dbSNP
rs903443741 1907 dbSNP
rs543686996 1915 dbSNP
rs1345271812 1920 dbSNP
rs1233120972 1926 dbSNP
rs1274999637 1931 dbSNP
rs1041796062 1933 dbSNP
rs1481510577 1935 dbSNP
rs1193952351 1939 dbSNP
rs766272565 1941 dbSNP
rs1452176014 1945 dbSNP
rs1010600355 1946 dbSNP
rs758061632 1947 dbSNP
rs1396982054 1950 dbSNP
rs1274758905 1951 dbSNP
rs893120210 1953 dbSNP
rs1373949449 1974 dbSNP
rs893547330 1980 dbSNP
rs1054360520 1982 dbSNP
rs1296847961 1993 dbSNP
rs1231200113 1995 dbSNP
rs1396399147 1996 dbSNP
rs1354621204 2005 dbSNP
rs1442352440 2010 dbSNP
rs753353757 2011 dbSNP
rs932248971 2013 dbSNP
rs1054916970 2017 dbSNP
rs922153796 2019 dbSNP
rs1040983633 2022 dbSNP
rs1439655011 2023 dbSNP
rs750246729 2023 dbSNP
rs906321617 2033 dbSNP
rs1328211080 2048 dbSNP
rs151130637 2051 dbSNP
rs1250608876 2052 dbSNP
rs1356894021 2056 dbSNP
rs1316356832 2058 dbSNP
rs1215492461 2063 dbSNP
rs1254929177 2064 dbSNP
rs1400587857 2071 dbSNP
rs1395830342 2072 dbSNP
rs982534765 2076 dbSNP
rs1262662359 2082 dbSNP
rs555262576 2088 dbSNP
rs939906836 2091 dbSNP
rs908487825 2093 dbSNP
rs1460202730 2104 dbSNP
rs1417669470 2108 dbSNP
rs919606707 2116 dbSNP
rs973702409 2118 dbSNP
rs761843731 2125 dbSNP
rs1288982845 2132 dbSNP
rs958616039 2138 dbSNP
rs1239819334 2139 dbSNP
rs754316601 2144 dbSNP
rs1355888610 2148 dbSNP
rs1235013799 2149 dbSNP
rs562471159 2152 dbSNP
rs1254780199 2154 dbSNP
rs921338813 2155 dbSNP
rs1333812527 2166 dbSNP
rs1486936742 2167 dbSNP
rs1003151328 2173 dbSNP
rs143032109 2176 dbSNP
rs1341766392 2179 dbSNP
rs149102529 2181 dbSNP
rs1434425713 2182 dbSNP
rs1020165826 2183 dbSNP
rs1475751614 2185 dbSNP
rs1190574311 2187 dbSNP
rs1416286698 2189 dbSNP
rs539174340 2192 dbSNP
rs1159125109 2193 dbSNP
rs977630412 2198 dbSNP
rs1010338426 2199 dbSNP
rs893192321 2201 dbSNP
rs1375736475 2207 dbSNP
rs1416362473 2208 dbSNP
rs968010829 2210 dbSNP
rs1021913712 2214 dbSNP
rs570059786 2217 dbSNP
rs146509709 2219 dbSNP
rs556619965 2221 dbSNP
rs900796966 2223 dbSNP
rs1260340744 2224 dbSNP
rs1040616347 2231 dbSNP
rs189478457 2232 dbSNP
rs567413340 2233 dbSNP
rs908054712 2236 dbSNP
rs1255866516 2237 dbSNP
rs184373714 2238 dbSNP
rs1046637441 2240 dbSNP
rs1167001819 2242 dbSNP
rs1409471595 2252 dbSNP
rs1416773241 2256 dbSNP
rs1157788249 2261 dbSNP
rs567329598 2269 dbSNP
rs1436267105 2270 dbSNP
rs929721515 2272 dbSNP
rs919639276 2273 dbSNP
rs1310785948 2282 dbSNP
rs939891670 2287 dbSNP
rs1442779361 2294 dbSNP
rs1396417134 2302 dbSNP
rs973775901 2303 dbSNP
rs887011320 2306 dbSNP
rs958349825 2310 dbSNP
rs1048331417 2312 dbSNP
rs1222111875 2320 dbSNP
rs931309719 2327 dbSNP
rs1191600689 2334 dbSNP
rs1468006271 2343 dbSNP
rs1233197191 2345 dbSNP
rs533701064 2350 dbSNP
rs1236778041 2355 dbSNP
rs921224188 2356 dbSNP
rs1039715087 2358 dbSNP
rs1205728046 2360 dbSNP
rs1235075690 2362 dbSNP
rs192313153 2366 dbSNP
rs7156379 2367 dbSNP
rs386778067 2368 dbSNP
rs7156375 2374 dbSNP
rs1455250774 2379 dbSNP
rs1305722278 2385 dbSNP
rs1394193913 2389 dbSNP
rs1410300894 2391 dbSNP
rs1065264 2396 dbSNP
rs1172320198 2397 dbSNP
rs1352682947 2400 dbSNP
rs562131275 2407 dbSNP
rs746166350 2410 dbSNP
rs1020128913 2411 dbSNP
rs1009991431 2433 dbSNP
rs1367545004 2445 dbSNP
rs1371858261 2447 dbSNP
rs1443316232 2452 dbSNP
rs1299291788 2456 dbSNP
rs914825842 2460 dbSNP
rs990362708 2463 dbSNP
rs1444770859 2467 dbSNP
rs1353185822 2469 dbSNP
rs1307009646 2473 dbSNP
rs377648738 2475 dbSNP
rs146526265 2477 dbSNP
rs1198572359 2478 dbSNP
rs1033049171 2479 dbSNP
rs1376703763 2483 dbSNP
rs1469434877 2485 dbSNP
rs1033318489 2494 dbSNP
rs1475574530 2502 dbSNP
rs755824395 2506 dbSNP
rs1188032253 2508 dbSNP
rs866508401 2510 dbSNP
rs970866793 2513 dbSNP
rs551776869 2519 dbSNP
rs996162782 2528 dbSNP
rs1165590773 2532 dbSNP
rs1396662513 2533 dbSNP
rs900483432 2537 dbSNP
rs1171230392 2538 dbSNP
rs1453324891 2540 dbSNP
rs1040754267 2548 dbSNP
rs1009166801 2554 dbSNP
rs1431773074 2555 dbSNP
rs886657685 2555 dbSNP
rs528907803 2559 dbSNP
rs1047896719 2570 dbSNP
rs1048216602 2573 dbSNP
rs1337636308 2574 dbSNP
rs144089784 2576 dbSNP
rs1288596504 2579 dbSNP
rs1232107161 2587 dbSNP
rs1447159121 2605 dbSNP
rs898280520 2608 dbSNP
rs541718684 2609 dbSNP
rs1217540380 2616 dbSNP
rs1240095420 2623 dbSNP
rs1477360759 2624 dbSNP
rs1188442234 2632 dbSNP
rs1204618068 2640 dbSNP
rs937013154 2642 dbSNP
rs1282501778 2644 dbSNP
rs899772947 2645 dbSNP
rs1474220996 2646 dbSNP
rs1208789227 2661 dbSNP
rs1311715230 2663 dbSNP
rs1308329759 2670 dbSNP
rs1390117403 2671 dbSNP
rs774807210 2672 dbSNP
rs373761759 2673 dbSNP
rs1401460708 2675 dbSNP
rs926996317 2676 dbSNP
rs981484091 2682 dbSNP
rs1399747524 2684 dbSNP
rs950004715 2691 dbSNP
rs1294361690 2695 dbSNP
rs1357900402 2696 dbSNP
rs189824089 2697 dbSNP
rs565524038 2698 dbSNP
rs912630719 2707 dbSNP
rs1414969630 2714 dbSNP
rs1041844695 2720 dbSNP
rs771308675 2746 dbSNP
rs545494760 2753 dbSNP
rs749848454 2757 dbSNP
rs1259374261 2761 dbSNP
rs957189567 2794 dbSNP
rs1186784741 2801 dbSNP
rs914711202 2805 dbSNP
rs1310742928 2806 dbSNP
rs1033081554 2807 dbSNP
rs551731081 2807 dbSNP
rs958922211 2811 dbSNP
rs927594764 2812 dbSNP
rs1313805714 2814 dbSNP
rs1377655785 2817 dbSNP
rs1161128450 2832 dbSNP
rs1398887694 2837 dbSNP
rs1406922863 2838 dbSNP
rs1334062899 2841 dbSNP
rs1188415399 2842 dbSNP
rs1476093058 2843 dbSNP
rs1259836035 2845 dbSNP
rs1163234754 2847 dbSNP
rs201190156 2848 dbSNP
rs1482956981 2849 dbSNP
rs3047556 2849 dbSNP
rs1352459622 2852 dbSNP
rs1261397350 2854 dbSNP
rs35799011 2855 dbSNP
rs1218471941 2856 dbSNP
rs1345493570 2858 dbSNP
rs980830051 2858 dbSNP
rs1199708876 2859 dbSNP
rs1268110020 2860 dbSNP
rs1439555162 2860 dbSNP
rs531891346 2861 dbSNP
rs970451134 2862 dbSNP
rs1397171065 2863 dbSNP
rs1450496104 2863 dbSNP
rs1491475527 2863 dbSNP
rs33920480 2863 dbSNP
rs372705600 2863 dbSNP
rs974818015 2863 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uguuCCGUAUACCAUGAGUCucu 5'
              |||| ||  | :||||   
Target 5' --uuGGCA-AUCAU-UUCAG--- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000247182.6 | 3UTR | UUGGCAAUCAUUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000247182.6 | 3UTR | UUGGCAAUCAUUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
77 hsa-miR-3921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118184 ZNF544 zinc finger protein 544 2 2
MIRT332934 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442165 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442388 CLVS2 clavesin 2 2 2
MIRT442594 SIX1 SIX homeobox 1 2 2
MIRT448015 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448062 MMP15 matrix metallopeptidase 15 2 2
MIRT489018 C1QTNF6 C1q and TNF related 6 2 2
MIRT494457 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495651 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504018 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506778 KLHL15 kelch like family member 15 2 4
MIRT507230 FOXN2 forkhead box N2 2 4
MIRT512551 MFN2 mitofusin 2 2 6
MIRT512843 A1CF APOBEC1 complementation factor 2 6
MIRT513943 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516104 GADL1 glutamate decarboxylase like 1 2 4
MIRT519832 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523209 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525007 ACTN4 actinin alpha 4 2 6
MIRT528859 PKP1 plakophilin 1 2 2
MIRT529061 ZNF675 zinc finger protein 675 2 2
MIRT531720 TARS threonyl-tRNA synthetase 2 2
MIRT534038 STK4 serine/threonine kinase 4 2 2
MIRT543849 APIP APAF1 interacting protein 2 2
MIRT545865 ZNF264 zinc finger protein 264 2 4
MIRT556038 MXD1 MAX dimerization protein 1 2 2
MIRT561346 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562706 ZNF415 zinc finger protein 415 2 2
MIRT563224 ZNF286A zinc finger protein 286A 2 2
MIRT563861 ZNF616 zinc finger protein 616 2 4
MIRT563880 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564653 ZNF487P zinc finger protein 487 1 1
MIRT566596 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570879 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573069 TRIB1 tribbles pseudokinase 1 2 2
MIRT573940 ZNF708 zinc finger protein 708 2 2
MIRT575967 Slfn5 schlafen 5 2 5
MIRT607294 CD300E CD300e molecule 2 4
MIRT608188 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609538 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610153 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611572 SLFN5 schlafen family member 5 2 7
MIRT613336 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616561 ZNF512B zinc finger protein 512B 2 2
MIRT617239 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618012 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618479 IL17REL interleukin 17 receptor E like 2 2
MIRT619100 IFI44L interferon induced protein 44 like 2 2
MIRT622266 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623081 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625622 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627845 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630460 GMPS guanine monophosphate synthase 2 2
MIRT630525 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631503 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634538 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638808 DCTN3 dynactin subunit 3 2 2
MIRT641304 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648348 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649706 ZNF175 zinc finger protein 175 2 2
MIRT652555 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655563 P2RX7 purinergic receptor P2X 7 2 2
MIRT659066 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660342 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664331 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688935 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689972 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699515 SKIL SKI like proto-oncogene 2 2
MIRT699976 RREB1 ras responsive element binding protein 1 2 2
MIRT702675 IRS2 insulin receptor substrate 2 2 2
MIRT709358 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709838 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718717 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718880 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724106 TMEM199 transmembrane protein 199 2 2
MIRT724764 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3921 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (SGC7901)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3921 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-3921 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-3921 Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-3921 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-3921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3921 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)

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