miRTarBase - #MIRT442663


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pre-miRNA Information
pre-miRNA hsa-mir-6767   
Genomic Coordinates chr16: 2445392 - 2445457
Description Homo sapiens miR-6767 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6767-3p
Sequence 45| CCACGUGCUUCUCUUUCCGCAG |66
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
722753 18 ClinVar
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1357663597 2 dbSNP
rs1195774168 3 dbSNP
rs1271299527 4 dbSNP
rs368889723 5 dbSNP
rs373559092 15 dbSNP
rs376429792 18 dbSNP
rs189194179 19 dbSNP
rs1189692059 22 dbSNP
Putative Targets

Gene Information
Gene Symbol GLRA2   
Synonyms GLR
Description glycine receptor alpha 2
Transcript NM_001118885   
Other Transcripts NM_001118886 , NM_001171942 , NM_002063   
Expression
Putative miRNA Targets on GLRA2
3'UTR of GLRA2
(miRNA target sites are highlighted)		 
>GLRA2|NM_001118885|3'UTR
   1 ATGTGCCCTACAGACCCTGGGACCTTCTTGCCTCAGTGTTGTGCTTGTAAATACACAGTGAAATTGTCTTTATATCACTT
  81 TGACAGAGGAGAAGATTGAGGGAGGGGGGAGGGAGGGTCATGGGGGTGGGTTTCCTGGCACCTACATGAAAAAAAAGACA
 161 AGTTATATGGGTGATGAAGAAAACTGCACAAAATTAAGGGGTTGCAGAATCACGGGAGCATAATAATTCCCTTCCATAAT
 241 CTTTAGCATTGTTCTTTCAGTCAGACATGATATGCGCAACATTCAGACATGATATGCGCATCATTCAGACATGATATGCG
 321 GGGTCAAGTTCTTAAGGGCTGTTTGCCTTTTGGTCCTTTTGGTTTGGTTTGGCTTTGACTAATTCTGGTACTGAAAAGTT
 401 AGCTATACACACACACACACACACACACACACACACACACACACACACACACACACACACACACAAACTTCAAAAATGCT
 481 TAACCATCTGACCATAGTGACTAGCCTATAGTGAGTCGAGGACCAAACTTTTTCAGGAAAATGCTGCCTCGTTTTTAAAA
 561 CAAGCCTCCTAAGCTATGTTCTTTACAATGTCTGTAATTAGTGTTTCACTTGAGAAAGCCTTTTGTGGGTCGTAAATTAT
 641 TTCTACTTATCCAGTAAATAACAATGACAAAATAAACACCAATGACAGAAAAATTTCTACTTTACTGTCCATATAGGTGT
 721 GCATTTTAATATTTTTCTTTCCAAGATAAAATTTTGAAACTTAAATTGTGTATTGTGTAATTAATTTGATAGTGTACCCT
 801 CTTAATAAATGCCCACTTTATTTTATATCCAAGTTAGTGCATTATATATATATTTTTGCTTTGGCTATATTTACACGTGA
 881 CTTTAATCGCCCAACTGTGACTAGTCATTGCAGCTACTCAGCTACAGTATTTATGGAGATGGTGTGTCCTGAACAGTGTA
 961 GCTCAGGTCAGCTTGAACTTTCCATTTCTGCTCTCATTGTAGGTGTAACTACTAGTCCTAATGTCAACTGACCCATGATT
1041 TCTACTGTCAGTCAATATAAGTGAACATTGTTTTAAATATCCTTAACTAACTTAAAGAATTTTAAAATTGTACTGTGATT
1121 TTCATAACCCGTTGCCTTTTTGGTACCAGAGCTACGTGGTTTGAATTCTGGCTACATGTTTTAAGTAAGAAAAAAAAAGA
1201 CGTATTTTTGCTTACTCAGATAAAAGACAACCTGTAAAAATATAATAATTAAATTTTACATGTGCTGTACAAGGGGTTAT
1281 TTTAAAAAGCATTTGTTCAATTTCAATAAAGCTAAGTGTGCCGCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacGCCUUUCUCUUCG-UGCACc 5'
             :|| |  || ||| ||||| 
Target 5' tttTGGTACCAG-AGCTACGTGg 3'
 1138 - 1159 122.00 -17.70
2 
miRNA  3' gacgccuuucucuucGUGCACc 5'
                         |||||| 
Target 5' ctttggctatatttaCACGTGa 3'
 859 - 880 120.00 -9.97
3 
miRNA  3' gacgccuuucucuucGUGCACc 5'
                         ||:||| 
Target 5' aataattaaattttaCATGTGc 3'
 1244 - 1265 104.00 -6.50
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs759194654 3 dbSNP
rs767105963 12 dbSNP
rs1259385923 15 dbSNP
rs752535220 18 dbSNP
rs371306095 24 dbSNP
rs777634221 25 dbSNP
rs375504397 26 dbSNP
rs1442476282 35 dbSNP
rs757084634 37 dbSNP
rs910485251 41 dbSNP
rs1361737695 42 dbSNP
rs368584181 45 dbSNP
rs372040848 47 dbSNP
rs1464114722 50 dbSNP
rs1394851919 53 dbSNP
rs1483679800 55 dbSNP
rs1198027872 62 dbSNP
rs1265842369 63 dbSNP
rs1244718850 86 dbSNP
rs1433031911 86 dbSNP
rs761372741 89 dbSNP
rs771545849 93 dbSNP
rs1397126717 103 dbSNP
rs1196283278 104 dbSNP
rs868214421 104 dbSNP
rs1447829592 106 dbSNP
rs1168064418 107 dbSNP
rs867309743 111 dbSNP
rs1371201310 112 dbSNP
rs867288764 115 dbSNP
rs1273481883 121 dbSNP
rs868337988 122 dbSNP
rs1378364543 127 dbSNP
rs867223191 128 dbSNP
rs1353955307 131 dbSNP
rs1335133701 137 dbSNP
rs953386372 146 dbSNP
rs1171834825 149 dbSNP
rs1423292525 149 dbSNP
rs1440063732 161 dbSNP
rs986575181 171 dbSNP
rs1387201959 195 dbSNP
rs1303050906 196 dbSNP
rs944617587 205 dbSNP
rs1176638190 214 dbSNP
rs1362593799 215 dbSNP
rs1489458638 217 dbSNP
rs1456946124 220 dbSNP
rs772902557 220 dbSNP
rs942074494 223 dbSNP
rs760254649 225 dbSNP
rs972143884 230 dbSNP
rs1440383463 231 dbSNP
rs1277456280 236 dbSNP
rs1210340104 241 dbSNP
rs945444486 243 dbSNP
rs1043870689 246 dbSNP
rs903926631 257 dbSNP
rs919399623 259 dbSNP
rs765600582 261 dbSNP
rs938842017 263 dbSNP
rs1284897110 265 dbSNP
rs1450272807 268 dbSNP
rs1264274154 273 dbSNP
rs1055280244 276 dbSNP
rs1362164262 277 dbSNP
rs1210827666 280 dbSNP
rs6630943 280 dbSNP
rs1414413839 281 dbSNP
rs1057380480 285 dbSNP
rs916190092 298 dbSNP
rs947740561 299 dbSNP
rs1216816772 302 dbSNP
rs1488835919 303 dbSNP
rs1463737949 306 dbSNP
rs1288554466 316 dbSNP
rs772742798 320 dbSNP
rs1390997514 321 dbSNP
rs763359063 322 dbSNP
rs1291202091 339 dbSNP
rs897536080 340 dbSNP
rs1376990600 342 dbSNP
rs1292932041 346 dbSNP
rs1400794038 358 dbSNP
rs993117698 361 dbSNP
rs1296165776 366 dbSNP
rs1452768004 367 dbSNP
rs764556287 374 dbSNP
rs1166744903 381 dbSNP
rs1162764533 385 dbSNP
rs1000547578 392 dbSNP
rs1367823586 399 dbSNP
rs752128593 400 dbSNP
rs1491309532 404 dbSNP
rs1185205016 405 dbSNP
rs1247807518 405 dbSNP
rs1260563639 405 dbSNP
rs1485744078 405 dbSNP
rs1491540326 405 dbSNP
rs73635050 406 dbSNP
rs1170833919 407 dbSNP
rs1199420657 407 dbSNP
rs1217246792 407 dbSNP
rs1252903881 407 dbSNP
rs1256410368 407 dbSNP
rs1268445213 407 dbSNP
rs1272668494 407 dbSNP
rs1295248357 407 dbSNP
rs1303192017 407 dbSNP
rs1312593525 407 dbSNP
rs1370233933 407 dbSNP
rs1393605141 407 dbSNP
rs1428315171 407 dbSNP
rs1434162168 407 dbSNP
rs1459091807 407 dbSNP
rs1466721299 407 dbSNP
rs1467562551 407 dbSNP
rs201991783 407 dbSNP
rs545585122 407 dbSNP
rs55910036 407 dbSNP
rs60175362 407 dbSNP
rs747829871 407 dbSNP
rs751739926 407 dbSNP
rs754597037 407 dbSNP
rs767517304 407 dbSNP
rs767561761 407 dbSNP
rs879052243 407 dbSNP
rs997328072 407 dbSNP
rs1434044758 409 dbSNP
rs1320867280 412 dbSNP
rs1366915693 413 dbSNP
rs1226124562 414 dbSNP
rs1311320010 415 dbSNP
rs1321671133 416 dbSNP
rs1246117101 417 dbSNP
rs1275564225 418 dbSNP
rs1327589862 419 dbSNP
rs1208479992 421 dbSNP
rs1248950253 423 dbSNP
rs1486933520 429 dbSNP
rs951813693 435 dbSNP
rs867759934 439 dbSNP
rs1255494797 445 dbSNP
rs866256094 447 dbSNP
rs1167062679 448 dbSNP
rs953453285 449 dbSNP
rs1409628545 450 dbSNP
rs1178759362 451 dbSNP
rs1452953286 453 dbSNP
rs866601438 453 dbSNP
rs1456573674 455 dbSNP
rs867482013 455 dbSNP
rs1159544619 457 dbSNP
rs1248461848 459 dbSNP
rs1195277280 463 dbSNP
rs1483731718 463 dbSNP
rs1007483468 465 dbSNP
rs1017410071 466 dbSNP
rs1016638320 467 dbSNP
rs1346617796 472 dbSNP
rs1445299523 491 dbSNP
rs963390347 492 dbSNP
rs1301788433 498 dbSNP
rs975956171 504 dbSNP
rs972112758 519 dbSNP
rs1433259053 521 dbSNP
rs913816008 522 dbSNP
rs945390598 529 dbSNP
rs1442132094 534 dbSNP
rs1362547857 541 dbSNP
rs1295718255 548 dbSNP
rs919366921 552 dbSNP
rs1258538955 557 dbSNP
rs960194966 557 dbSNP
rs1186008798 566 dbSNP
rs1485235490 571 dbSNP
rs1286522931 575 dbSNP
rs1218487729 585 dbSNP
rs993031979 587 dbSNP
rs781146084 588 dbSNP
rs114347818 591 dbSNP
rs979414624 594 dbSNP
rs1310161852 596 dbSNP
rs1318978886 604 dbSNP
rs1340715741 610 dbSNP
rs1208228878 613 dbSNP
rs1299249095 615 dbSNP
rs866370133 621 dbSNP
rs948946093 623 dbSNP
rs760289834 633 dbSNP
rs1383519260 652 dbSNP
rs925382244 655 dbSNP
rs1255592324 660 dbSNP
rs938085227 667 dbSNP
rs1162839427 669 dbSNP
rs1264154521 683 dbSNP
rs1475030096 683 dbSNP
rs1190134457 684 dbSNP
rs1195659822 685 dbSNP
rs188417275 685 dbSNP
rs1444996504 709 dbSNP
rs1043333821 711 dbSNP
rs1260969732 715 dbSNP
rs1210307319 718 dbSNP
rs924912874 720 dbSNP
rs1270772839 727 dbSNP
rs936370407 727 dbSNP
rs1249540208 734 dbSNP
rs11795712 735 dbSNP
rs1182664642 736 dbSNP
rs749068683 741 dbSNP
rs760723798 742 dbSNP
rs1318276323 743 dbSNP
rs1412513353 759 dbSNP
rs1174974637 761 dbSNP
rs1393486151 761 dbSNP
rs1162948248 763 dbSNP
rs1460981684 769 dbSNP
rs1359369538 771 dbSNP
rs1173013121 774 dbSNP
rs896614698 775 dbSNP
rs1199270909 778 dbSNP
rs754857846 778 dbSNP
rs1051998722 789 dbSNP
rs1251053235 790 dbSNP
rs1305566531 797 dbSNP
rs888955141 813 dbSNP
rs1371686113 817 dbSNP
rs949553971 817 dbSNP
rs1284904484 819 dbSNP
rs1037279794 832 dbSNP
rs180780868 833 dbSNP
rs1212389494 837 dbSNP
rs748150864 842 dbSNP
rs771548444 843 dbSNP
rs887538938 843 dbSNP
rs1324387115 851 dbSNP
rs772632148 853 dbSNP
rs1401056141 860 dbSNP
rs746628623 869 dbSNP
rs1408468415 873 dbSNP
rs1017856957 877 dbSNP
rs965905820 878 dbSNP
rs1016192893 882 dbSNP
rs1393204045 882 dbSNP
rs1300913053 889 dbSNP
rs1020910175 890 dbSNP
rs770470560 890 dbSNP
rs963358613 891 dbSNP
rs1436921115 896 dbSNP
rs979445802 907 dbSNP
rs925278607 909 dbSNP
rs1482707879 910 dbSNP
rs1301906945 928 dbSNP
rs777162383 928 dbSNP
rs938101911 929 dbSNP
rs1440101529 930 dbSNP
rs993538724 935 dbSNP
rs1205834455 938 dbSNP
rs1026395764 939 dbSNP
rs1335025550 943 dbSNP
rs1436370696 953 dbSNP
rs1373339790 955 dbSNP
rs1172971089 967 dbSNP
rs185879145 968 dbSNP
rs1420275236 970 dbSNP
rs763305543 972 dbSNP
rs990959803 976 dbSNP
rs917987854 995 dbSNP
rs11796093 998 dbSNP
rs1237709232 999 dbSNP
rs1189128460 1006 dbSNP
rs1190406339 1023 dbSNP
rs763160966 1028 dbSNP
rs1486873832 1037 dbSNP
rs1278685475 1047 dbSNP
rs949583677 1048 dbSNP
rs1037144106 1054 dbSNP
rs1286955596 1059 dbSNP
rs1425436646 1063 dbSNP
rs1222149284 1077 dbSNP
rs1372630742 1083 dbSNP
rs1285027795 1084 dbSNP
rs1416813057 1085 dbSNP
rs1455258375 1088 dbSNP
rs1312106204 1090 dbSNP
rs1400375795 1092 dbSNP
rs918859612 1098 dbSNP
rs1166197192 1111 dbSNP
rs1156769517 1118 dbSNP
rs1164310358 1119 dbSNP
rs1399639472 1130 dbSNP
rs1369357404 1131 dbSNP
rs774782427 1132 dbSNP
rs1166424769 1137 dbSNP
rs1330199906 1144 dbSNP
rs17264518 1145 dbSNP
rs1356770876 1147 dbSNP
rs931538826 1150 dbSNP
rs916041201 1156 dbSNP
rs970266135 1157 dbSNP
rs1488785838 1167 dbSNP
rs1434841552 1172 dbSNP
rs887410510 1182 dbSNP
rs979410804 1182 dbSNP
rs1372031949 1186 dbSNP
rs1236728307 1187 dbSNP
rs1007633981 1190 dbSNP
rs1316446394 1190 dbSNP
rs200841621 1190 dbSNP
rs1333046406 1191 dbSNP
rs901578644 1203 dbSNP
rs1341608999 1214 dbSNP
rs1363752813 1215 dbSNP
rs926232079 1216 dbSNP
rs1429979402 1218 dbSNP
rs1350373139 1229 dbSNP
rs762232583 1232 dbSNP
rs1449731920 1242 dbSNP
rs1459413072 1242 dbSNP
rs1220573628 1244 dbSNP
rs1416726301 1245 dbSNP
rs1020776182 1246 dbSNP
rs1170880915 1246 dbSNP
rs1422046195 1248 dbSNP
rs1185111450 1258 dbSNP
rs987800160 1264 dbSNP
rs913577489 1267 dbSNP
rs1000755489 1268 dbSNP
rs1247788886 1271 dbSNP
rs753940523 1272 dbSNP
rs191148061 1274 dbSNP
rs1467146648 1277 dbSNP
rs762109260 1277 dbSNP
rs1186321407 1288 dbSNP
rs1219435614 1296 dbSNP
rs1309448202 1300 dbSNP
rs766115730 1305 dbSNP
rs991215505 1313 dbSNP
rs1368303625 1323 dbSNP
rs1038002583 1324 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000218075.4 | 3UTR | UUGGCUAUAUUUACAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
42 hsa-miR-6767-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066671 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 4
MIRT442663 GLRA2 glycine receptor alpha 2 2 2
MIRT457038 S1PR3 sphingosine-1-phosphate receptor 3 2 2
MIRT487824 HIST1H2AH histone cluster 1 H2A family member h 2 6
MIRT500161 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT505924 RCAN3 RCAN family member 3 2 4
MIRT529861 GPR173 G protein-coupled receptor 173 2 2
MIRT569240 SUSD1 sushi domain containing 1 2 2
MIRT575091 Slc1a5 solute carrier family 1 (neutral amino acid transporter), member 5 2 5
MIRT575972 Slfn5 schlafen 5 2 3
MIRT606881 SLC1A5 solute carrier family 1 member 5 2 7
MIRT607097 SLFN5 schlafen family member 5 2 3
MIRT607990 NSUN3 NOP2/Sun RNA methyltransferase family member 3 2 6
MIRT608479 RRP36 ribosomal RNA processing 36 2 2
MIRT610984 GNA14 G protein subunit alpha 14 2 2
MIRT612308 WDR37 WD repeat domain 37 2 4
MIRT612777 MATN1 matrilin 1, cartilage matrix protein 2 4
MIRT615030 DNAL1 dynein axonemal light chain 1 2 2
MIRT615500 MPP2 membrane palmitoylated protein 2 2 2
MIRT618026 ELFN1 extracellular leucine rich repeat and fibronectin type III domain containing 1 2 2
MIRT618763 HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2 2
MIRT621458 STX1B syntaxin 1B 2 2
MIRT622221 SLC36A1 solute carrier family 36 member 1 2 2
MIRT628784 TMEM154 transmembrane protein 154 2 2
MIRT632385 SNAPC3 small nuclear RNA activating complex polypeptide 3 2 2
MIRT652751 TFAM transcription factor A, mitochondrial 2 2
MIRT661806 NUP85 nucleoporin 85 2 2
MIRT663148 RD3 retinal degeneration 3 2 2
MIRT663867 MUC20 mucin 20, cell surface associated 2 2
MIRT664448 CCDC108 cilia and flagella associated protein 65 2 2
MIRT669932 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT670303 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT672171 FAM174B family with sequence similarity 174 member B 2 2
MIRT672280 SHE Src homology 2 domain containing E 2 2
MIRT678057 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT679781 GOLGA2 golgin A2 2 2
MIRT683451 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT684218 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT690932 RAD51 RAD51 recombinase 2 2
MIRT692944 EXOSC2 exosome component 2 2 2
MIRT700401 RAB13 RAB13, member RAS oncogene family 2 2
MIRT724462 PRKX protein kinase, X-linked 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6767 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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