pre-miRNA Information | |
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pre-miRNA | hsa-mir-4307 |
Genomic Coordinates | chr14: 26908642 - 26908725 |
Description | Homo sapiens miR-4307 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4307 | |||||||||||||||||||||||||||
Sequence | 56| AAUGUUUUUUCCUGUUUCC |74 | |||||||||||||||||||||||||||
Evidence | Experimental | |||||||||||||||||||||||||||
Experiments | SOLiD | |||||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | SLC39A9 | ||||||||||||||||||||
Synonyms | ZIP-9, ZIP9 | ||||||||||||||||||||
Description | solute carrier family 39 member 9 | ||||||||||||||||||||
Transcript | NM_018375 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on SLC39A9 | |||||||||||||||||||||
3'UTR of SLC39A9 (miRNA target sites are highlighted) |
>SLC39A9|NM_018375|3'UTR 1 ATGTTCAAGGTCCAGCCTTGGTCCAGGGCCGTTTGCCATCCAGTGAGAACAGCCGGCACGTGACAGCTACTCACTTCCTC 81 AGTCTCTTGTCTCACCTTGCGCATCTCTACATGTATTCCTAGAGTCCAGAGGGGAGGTGAGGTTAAAACCTGAGTAATGG 161 AAAAGCTTTTAGAGTAGAAACACATTTACGTTGCAGTTAGCTATAGACATCCCATTGTGTTATCTTTTAAAAGGCCCTTG 241 ACATTTTGCGTTTTAATATTTCTCTTAACCCTATTCTCAGGGAAGATGGAATTTAGTTTTAAGGAAAAGAGGAGAACTTC 321 ATACTCACAATGAAATAGTGATTATGAAAATACAGTGTTCTGTAATTAAGCTATGTCTCTTTCTTCTTAGTTTAGAGGCT 401 CTGCTACTTTATCCATTGATTTTTAACATGGTTCCCACCATGTAAGACTGGTGCTTTAGCATCTATGCCACATGCGTTGA 481 TGGAAGGTCATAGCACCCACTCACTTAGATGCTAAAGGTGATTCTAGTTAATCTGGGATTAGGGTCAGGAAAATGATAGC 561 AAGACACATTGAAAGCTCTCTTTATACTCAAAAGAGATATCCATTGAAAAGGGATGTCTAGAGGGATTTAAACAGCTCCT 641 TTGGCACGTGCCTCTCTGAATCCAGCCTGCCATTCCATCAAATGGAGCAGGAGAGGTGGGAGGAGCTTCTAAAGAGGTGA 721 CTGGTATTTTGTAGCATTCCTTGTCAAGTTCTCCTTTGCAGAATACCTGTCTCCACATTCCTAGAGAGGAGCCAAGTTCT 801 AGTAGTTTCAGTTCTAGGCTTTCCTTCAAGAACAGTCAGATCACAAAGTGTCTTTGGAAATTAAGGGATATTAAATTTTA 881 AGTGATTTTTGGATGGTTATTGATATCTTTGTAGTAGCTTTTTTTAAAAGACTACCAAAATGTATGGTTGTCCTTTTTTT 961 TTGTTTTTTTTTTTTTTAATTATTTCTCTTAGCAGATCAGCAATCCCTCTAGGGACCTAAATACTAGGTCAGCTTTGGCG 1041 ACACTGTGTCTTCTCACATAACCACCTGTAGCAAGATGGATCATAAATGAGAAGTGTTTGCCTATTGATTTAAAGCTTAT 1121 TGGAATCATGTCTCTTGTCTCTTCGTCTTTTCTTTGCTTTTCTTCTAACTTTTCCCTCTAGCCTCTCCTCGCCACAATTT 1201 GCTGCTTACTGCTGGTGTTAATATTTGTGTGGGATGAATTCTTATCAGGACAACCACTTCTCGAACTGTAATAATGAAGA 1281 TAATAATATCTTTATTCTTTATCCCCCTTCAAAGAAATTACCTTTGTGTCAAATGCCGCTTTGTTGAGCCCTTAAAATAC 1361 CACCTCCTCATGTGTAAATTGACACAATCACTAATCTGGTAATTTAAACAATTGAGATAGCAAAAGTGTTTAACAGACTA 1441 GGATAATTTTTTTTTCATATTTGCCAAAATTTTTGTAAACCCTGTCTTGTCAAATAAGTGTATAATATTGTATTATTAAT 1521 TTATTTTTACTTTCTATACCATTTCAAAACACATTACACTAAGGGGGAACCAAGACTAGTTTCTTCAGGGCAGTGGACGT 1601 AGTAGTTTGTAAAAACGTTTTCTATGACGCATAAGCTAGCATGCCTATGATTTATTTCCTTCATGAATTTGTCACTGGAT 1681 CAGCAGCTGTGGAAATAAAGCTTGTGAGCCCTCTGCTGGCCACAGTGAGGAAAGTAGCACAAATAGGATACAGTTGTATG 1761 TAGTCATTGGCAACAATTGCATACAATTTTACTACCAAGAGAAGGTATAGTATGGAAAGTCCAAATGACTTCCTTGATTG 1841 GATGTTAACAGCTGACTGGTGTGAGACTTGAGGTTTCATCTAGTCCTTCAAAACTATATGGTTGCCTAGATTCTCTCTGG 1921 AAACTGACTTTGTCAAATAAATAGCAGATTGTAGTGTCTGGTTTGGTTTGGACAGTAGTGCTTTCTATCATATTGTTGTG 2001 TGCAATGGTAATTTGTTCTACTGGCCAAAGCCTCTTTCAGCAGTGCCTTGCCATCATGCTTAAAAGTTTGGCTAGTATAT 2081 CTTGCTGGATGGAGCCTTGAACTCCGGCAAGGATTGAACCATCTGACTTCCAAATTTGCCTTCCCCTCTGGACCTCACTA 2161 TTAACAAGCAAACCTTTCAGGGCCCTCTTAGCTCTCAGAAGCTATGTATGGGCTTTCCCAGATTTTAAAGCTGCTGCCTC 2241 GAGAACTACTCATTTCTCTCCTGGTCAGCAGACAGAAATAGCCATACTAATCTCATAGGGCTCAAATGCATCTTCAGGCA 2321 GCAGGGAACCAAGCAGCGTGGCACAGGCCTTCTTGACTGGAGGAAGAGCTTGCTGGCATGGTGGGCAGTATTCCAGGAGA 2401 GGCCATGTCCGTGTTCACTTCTTGGCACATTTCAGTTCCGTTTTCCTCTTGTTTAAAACTGCCTCTTTAGATGTGGATGC 2481 CTTAATGCTGTAACACATTTGAAAACATTGGCAATACTTAAGTTGCTGCCATGATTACAGATGGAATTATTGGCTACCAA 2561 AGAGACGCAATTGATGATGAGAAGCATGATTCTTGCTTCCATATAACCAAAGTTAATCTTAATTGCAATTTGACTCCGTT 2641 TCCTTGGTAGGGATAGACTTTCTTCAGATTCCAAGTGCTCTCTTAAATGGCAAATTAAGTTAAAGAATACTACTGCTCCA 2721 TTCCCCTCACTTATTCTCCAGTTAATTGCTTGTCAGTTCCATTTCAAGAAAGCAGTGATGTTCCAGGTTTGATTCAGTTT 2801 TCCTGTGCACACTATTGCCAAATTTTTTTTTAGCAAAGATTCTGCACTGGAACGTAGACAGTTGGAAACAGTACTACCTA 2881 CCTAGAGGTTATGTGTTTTCTCTTTCTCCCCGCTTTCACCTCTTTCTTTCCCAATTCAAAACAGCCAAGTGAGCCCTGTT 2961 CTGGTATTTTGAATCATTAGAGAAAAGAAAGGGAGTGGCTGTTTTGAGTTGTCCTTTCTTTGCAGAAAGGAGAAAATGTG 3041 ATTGTGTTTTTTTTTTACCAGCCTACTTCTAAGTGTCACTGCCTGGTTTTTCTCTTTTTCAAGGATTAGAACTAAGAGGA 3121 CACACCAGCATCGGAGTGTATTAAGCCCCTGAAACACATGGTAGCTAGGGACTGAACACAGGAACCGTATGACAGCAGCA 3201 CAAACCCCCAAAGGATGTTCCTGCCTTGTGGGCCCCTGAGCCCCTTGGGAGACTGAGAATCATGACCAGATTCATCCAGA 3281 ACTGCTGCAGTGTTAAGTGAAAATCCTCTGTAGTTGTTCTGCAGAGGAACCTTCCTTCCATTAGAAAATTTCTGCTCAAT 3361 ACAGAATGGTCCACATCACCCAAAGTGCACTGTTGGAGATGCTGTGAAATTAAAACCTCTTTGTACCTGAGACATCTAGA 3441 TTCACCTCAGGAGGCCTGAAGGAAATGTGTAACTTGTGGGAAAGAACTAGACAACCATTTAGGAATTCTCTAGATATACT 3521 CAGCCTAACCCAGTGGCTTAACACAAGGAGATTGGCTTTGATCTTTTTTTCTTGTGGCATCTTCCAGCAAGTTAGAAGTC 3601 TCATGGGATAAGACTGCAGTTCCCCTGGTTCAATAGCTGGAACAGTGATTTTAAATGTCCCTTTTTCTGGATCCCTTGTA 3681 AACATGAAATCATTCCATGGATGGCTGCCTTATAATTTTGTCTCTTTCCACTTTAATTGTGAATGGTTAAAAAAATGCTG 3761 TTTTCTGATATTAAATTTTTATTAGTGCATACCTTAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | BC-3 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796040 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-3 / 4-Thiouridine |
Location of target site | ENST00000031146.4 | 3UTR | UUGGCAAUACUUAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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107 hsa-miR-4307 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT091681 | RARB | retinoic acid receptor beta | 2 | 6 | ||||||||
MIRT097311 | AGGF1 | angiogenic factor with G-patch and FHA domains 1 | 2 | 2 | ||||||||
MIRT099878 | SOX4 | SRY-box 4 | 2 | 2 | ||||||||
MIRT114514 | ARF6 | ADP ribosylation factor 6 | 2 | 2 | ||||||||
MIRT163479 | WNT5A | Wnt family member 5A | 2 | 2 | ||||||||
MIRT186633 | COX20 | COX20, cytochrome c oxidase assembly factor | 2 | 8 | ||||||||
MIRT194921 | TNRC6A | trinucleotide repeat containing 6A | 2 | 2 | ||||||||
MIRT230189 | AKAP17A | A-kinase anchoring protein 17A | 2 | 2 | ||||||||
MIRT281397 | MAPK6 | mitogen-activated protein kinase 6 | 2 | 2 | ||||||||
MIRT328018 | RLIM | ring finger protein, LIM domain interacting | 2 | 2 | ||||||||
MIRT354896 | SEC62 | SEC62 homolog, preprotein translocation factor | 2 | 2 | ||||||||
MIRT361422 | PNRC1 | proline rich nuclear receptor coactivator 1 | 2 | 2 | ||||||||
MIRT442526 | MOB3B | MOB kinase activator 3B | 2 | 2 | ||||||||
MIRT442629 | NUDT12 | nudix hydrolase 12 | 2 | 2 | ||||||||
MIRT442685 | SLC39A9 | solute carrier family 39 member 9 | 2 | 2 | ||||||||
MIRT444131 | BRCA2 | BRCA2, DNA repair associated | 2 | 2 | ||||||||
MIRT444174 | RBM7 | RNA binding motif protein 7 | 2 | 2 | ||||||||
MIRT446045 | TPR | translocated promoter region, nuclear basket protein | 2 | 2 | ||||||||
MIRT447984 | LINC00598 | long intergenic non-protein coding RNA 598 | 2 | 2 | ||||||||
MIRT460527 | S100A11 | S100 calcium binding protein A11 | 2 | 4 | ||||||||
MIRT466861 | STX6 | syntaxin 6 | 2 | 2 | ||||||||
MIRT468806 | SAP18 | Sin3A associated protein 18 | 2 | 6 | ||||||||
MIRT480269 | C8orf4 | chromosome 8 open reading frame 4 | 2 | 2 | ||||||||
MIRT493119 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | 2 | 6 | ||||||||
MIRT499168 | YRDC | yrdC N6-threonylcarbamoyltransferase domain containing | 2 | 8 | ||||||||
MIRT500507 | ZBTB34 | zinc finger and BTB domain containing 34 | 2 | 2 | ||||||||
MIRT503021 | CAND1 | cullin associated and neddylation dissociated 1 | 2 | 2 | ||||||||
MIRT505314 | TOR1AIP2 | torsin 1A interacting protein 2 | 2 | 2 | ||||||||
MIRT506123 | PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 2 | 8 | ||||||||
MIRT509346 | CYP20A1 | cytochrome P450 family 20 subfamily A member 1 | 2 | 4 | ||||||||
MIRT509446 | POU2F2 | POU class 2 homeobox 2 | 2 | 6 | ||||||||
MIRT509598 | PEX26 | peroxisomal biogenesis factor 26 | 2 | 2 | ||||||||
MIRT516008 | GPN2 | GPN-loop GTPase 2 | 2 | 2 | ||||||||
MIRT516120 | SRPX2 | sushi repeat containing protein, X-linked 2 | 2 | 4 | ||||||||
MIRT522126 | NELL2 | neural EGFL like 2 | 2 | 2 | ||||||||
MIRT523018 | IL1RAPL1 | interleukin 1 receptor accessory protein like 1 | 2 | 4 | ||||||||
MIRT524015 | DONSON | downstream neighbor of SON | 2 | 2 | ||||||||
MIRT526307 | JAKMIP2 | janus kinase and microtubule interacting protein 2 | 2 | 2 | ||||||||
MIRT526789 | SGCD | sarcoglycan delta | 2 | 2 | ||||||||
MIRT529141 | CLCC1 | chloride channel CLIC like 1 | 2 | 2 | ||||||||
MIRT531336 | GDPD1 | glycerophosphodiester phosphodiesterase domain containing 1 | 2 | 2 | ||||||||
MIRT531573 | ILDR1 | immunoglobulin like domain containing receptor 1 | 2 | 2 | ||||||||
MIRT531831 | MTPAP | mitochondrial poly(A) polymerase | 2 | 2 | ||||||||
MIRT534994 | PRR11 | proline rich 11 | 2 | 6 | ||||||||
MIRT535419 | PDZD8 | PDZ domain containing 8 | 2 | 2 | ||||||||
MIRT535534 | PAK2 | p21 (RAC1) activated kinase 2 | 2 | 2 | ||||||||
MIRT536649 | INIP | INTS3 and NABP interacting protein | 2 | 2 | ||||||||
MIRT543498 | MDM2 | MDM2 proto-oncogene | 2 | 4 | ||||||||
MIRT545392 | PM20D2 | peptidase M20 domain containing 2 | 2 | 2 | ||||||||
MIRT545881 | ZNF200 | zinc finger protein 200 | 2 | 4 | ||||||||
MIRT547931 | HNRNPR | heterogeneous nuclear ribonucleoprotein R | 2 | 2 | ||||||||
MIRT548109 | GDAP2 | ganglioside induced differentiation associated protein 2 | 2 | 2 | ||||||||
MIRT549370 | ANKS1A | ankyrin repeat and sterile alpha motif domain containing 1A | 2 | 2 | ||||||||
MIRT549934 | RPL7L1 | ribosomal protein L7 like 1 | 2 | 4 | ||||||||
MIRT550455 | MYADM | myeloid associated differentiation marker | 2 | 4 | ||||||||
MIRT550640 | AR | androgen receptor | 2 | 2 | ||||||||
MIRT550815 | FAM229B | family with sequence similarity 229 member B | 2 | 2 | ||||||||
MIRT551258 | OPCML | opioid binding protein/cell adhesion molecule like | 2 | 2 | ||||||||
MIRT551768 | MED21 | mediator complex subunit 21 | 2 | 2 | ||||||||
MIRT552214 | ATP5S | ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) | 2 | 2 | ||||||||
MIRT555472 | POGZ | pogo transposable element derived with ZNF domain | 2 | 2 | ||||||||
MIRT556008 | MZT1 | mitotic spindle organizing protein 1 | 2 | 2 | ||||||||
MIRT557878 | FEM1B | fem-1 homolog B | 2 | 4 | ||||||||
MIRT558486 | DBN1 | drebrin 1 | 2 | 2 | ||||||||
MIRT560859 | GAL3ST3 | galactose-3-O-sulfotransferase 3 | 2 | 2 | ||||||||
MIRT561521 | AZF1 | azoospermia factor 1 | 2 | 2 | ||||||||
MIRT562090 | KIAA0895 | KIAA0895 | 2 | 2 | ||||||||
MIRT563065 | ZNF28 | zinc finger protein 28 | 2 | 2 | ||||||||
MIRT563487 | ZWINT | ZW10 interacting kinetochore protein | 2 | 2 | ||||||||
MIRT564286 | CTCF | CCCTC-binding factor | 2 | 2 | ||||||||
MIRT565627 | SLC16A1 | solute carrier family 16 member 1 | 2 | 2 | ||||||||
MIRT566508 | PAWR | pro-apoptotic WT1 regulator | 2 | 2 | ||||||||
MIRT566978 | LBR | lamin B receptor | 2 | 2 | ||||||||
MIRT567180 | IGFBP5 | insulin like growth factor binding protein 5 | 2 | 2 | ||||||||
MIRT568432 | GDNF | glial cell derived neurotrophic factor | 2 | 2 | ||||||||
MIRT570092 | KANSL1L | KAT8 regulatory NSL complex subunit 1 like | 2 | 2 | ||||||||
MIRT570565 | PABPC1 | poly(A) binding protein cytoplasmic 1 | 2 | 2 | ||||||||
MIRT571385 | JKAMP | JNK1/MAPK8-associated membrane protein | 2 | 2 | ||||||||
MIRT572053 | GPATCH8 | G-patch domain containing 8 | 2 | 2 | ||||||||
MIRT572333 | CACNA1A | calcium voltage-gated channel subunit alpha1 A | 2 | 2 | ||||||||
MIRT574528 | PEG10 | paternally expressed 10 | 2 | 2 | ||||||||
MIRT575818 | Igfbp4 | insulin-like growth factor binding protein 4 | 2 | 2 | ||||||||
MIRT608587 | PPP2R1B | protein phosphatase 2 scaffold subunit Abeta | 2 | 4 | ||||||||
MIRT610442 | TSPAN15 | tetraspanin 15 | 2 | 2 | ||||||||
MIRT614994 | GABRB1 | gamma-aminobutyric acid type A receptor beta1 subunit | 2 | 2 | ||||||||
MIRT615014 | ERGIC2 | ERGIC and golgi 2 | 2 | 2 | ||||||||
MIRT615078 | CISD3 | CDGSH iron sulfur domain 3 | 2 | 2 | ||||||||
MIRT616180 | SYT7 | synaptotagmin 7 | 2 | 2 | ||||||||
MIRT617191 | CDH13 | cadherin 13 | 2 | 2 | ||||||||
MIRT617287 | GTF2H3 | general transcription factor IIH subunit 3 | 2 | 2 | ||||||||
MIRT618714 | ESD | esterase D | 2 | 2 | ||||||||
MIRT621825 | TIMM8B | translocase of inner mitochondrial membrane 8 homolog B | 2 | 2 | ||||||||
MIRT624139 | DLX3 | distal-less homeobox 3 | 2 | 2 | ||||||||
MIRT625991 | IBA57 | IBA57 homolog, iron-sulfur cluster assembly | 2 | 2 | ||||||||
MIRT626344 | BLOC1S4 | biogenesis of lysosomal organelles complex 1 subunit 4 | 2 | 2 | ||||||||
MIRT634899 | ZNF701 | zinc finger protein 701 | 2 | 2 | ||||||||
MIRT637848 | SLC2A9 | solute carrier family 2 member 9 | 2 | 2 | ||||||||
MIRT639514 | FYB | FYN binding protein 1 | 2 | 2 | ||||||||
MIRT642468 | RSL1D1 | ribosomal L1 domain containing 1 | 2 | 2 | ||||||||
MIRT653670 | SLC26A7 | solute carrier family 26 member 7 | 2 | 2 | ||||||||
MIRT655192 | PHAX | phosphorylated adaptor for RNA export | 2 | 2 | ||||||||
MIRT657011 | KCNMB4 | potassium calcium-activated channel subfamily M regulatory beta subunit 4 | 2 | 2 | ||||||||
MIRT661008 | ABCB11 | ATP binding cassette subfamily B member 11 | 2 | 2 | ||||||||
MIRT665816 | TMEM161B | transmembrane protein 161B | 2 | 2 | ||||||||
MIRT683852 | ZNF208 | zinc finger protein 208 | 2 | 2 | ||||||||
MIRT700436 | PURB | purine rich element binding protein B | 2 | 2 | ||||||||
MIRT700517 | PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 2 | 2 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||
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