miRTarBase - #MIRT442829


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pre-miRNA Information
pre-miRNA hsa-mir-6501   
Genomic Coordinates chr21: 33550662 - 33550728
Description Homo sapiens miR-6501 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6501-5p
Sequence 3| AGUUGCCAGGGCUGCCUUUGGU |24
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
1055619 20 ClinVar
COSM5974214 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756127353 5 dbSNP
rs764400023 6 dbSNP
rs753967693 8 dbSNP
rs1283296362 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol AZIN1   
Synonyms AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L
Description antizyme inhibitor 1
Transcript NM_015878   
Other Transcripts NM_148174   
Expression
Putative miRNA Targets on AZIN1
3'UTR of AZIN1
(miRNA target sites are highlighted)		 
>AZIN1|NM_015878|3'UTR
   1 ACAGGCATTAACGCTTCTTTAGATCTGAAGTTGCAGGTTAAGCTTGTCTGGTCAACATTCCAGTGTGGAAAAATAATTTA
  81 AACAATCTTATTCTCTTAATTCTTTTGGCAACAAAAACTATTAGTAATAGCTATTTGGGACCAGACAAAATCAGCTTTCA
 161 TCTATAATTCATTGGGGATAATGGGAGATTTAGATAATGTATCCAGATTTAAACCTACCAGTTTGTCCTACCCCTTAAGC
 241 GTTTAAAATAAAATATGCAACAAAATGGATGACTTAGTGGAGATGGAAGCCCATTAATTGGGTTCCCCATTAAATCGTTT
 321 ACATACAAGAACACAGTTTTTATACTAAGGATTTGTGTTTAAAGTCTTGTAAAGTTCATGTCTTTCACCCAGATATATCA
 401 AATGTTAGAAGACCAGTGTGACTTCATTAGATAACGTTTAGTGTATTTAGAATGTGTAAATTTGTGCTTTGAACTGTAGT
 481 TTAATAAATGTAAAATTGCATCATAGTATTTGTTGACCTAATGTAACCCTTGTATGATTGCAATAAAATTTTGTGTAGAT
 561 TTTACTGTTTTTTCAGGCTAAAACTTTGGGAAAGGGGCTAGCTAGCAAAGGTAGTTTTGAAATAGATGTGTATATGGACT
 641 GTTTTGAAGGGTTTTTTTCTTTATAGCCCAGTTAAGTTTTGTTTGGCTCGGTGCATTTTTCATTTATTTAATTAGTAATT
 721 TAAGTAAAGTGTTTGGTAAATCATTGTGAAGTTCAGATTCATTATGGAGAGTTGATGTGCAGTAAGCATGATGTTTAACA
 801 ATTTTAACACCAAAAATGTTAATCCTGCATAAATCAACTGTAATAATAAATAGGTGTTTCTGTATAGATAGAATGCATAG
 881 AGTACCTTAGTAAATCTTTGAATCACAATCTTTTGGCTGAAATGGAAGATTCTGTTAAATACTTTGAATAAACTTGGGGG
 961 GAGGGAAATAAAATTGCAGAAAACTGCAGAGCACTAAAACTTAAAGAAGGGCTACATCTTTATCCAGAAACCTGTTGCTC
1041 TTTTGCACGGAATGTTTAAATTCAGAGTTGGGATGGGGGTTGGGGTGAAGCACACTTATTATCTTCAGTTGCAGTGATTT
1121 CAAATTTAGGATTTTTTGTTGTTGGTTTGAACTGTCCCCTTAGTTTCTTGTTATTTCCAATTTGTTCTGCTTAGTCATTA
1201 CTTTTAATTCTTTTCTTACTAAAATTTTATGGTGGTTGGGGGAAGGGAGTTAGCATCACTAACCTGACAGTTGTTGCCAG
1281 GAATTTGCTTTGTTTACTGCTAGTATATTAGAAATCCTAGATCTCAGAATCACAATAGTAATAAACAACAGGGGTCATTT
1361 TTTCCTAACTTACTCTGTGTTCAGGTGTGGAATTTCTGTCTCCCAAGAGGAAATGTGACTTCACTTTGGTGCCAATGGAC
1441 AGAAAATTCTACCTGTGCTACATAGGAGAAGTTTGGAATGCACTTAATAGCTGGTTTTTACACCTTGATTTCGAGGTGGA
1521 AAGAAATTGATCATGAATCTCTAATAAATTTAAATCTCTTAAACCAGTAGGTGCTTAATATTTTTTGATTTGATTAATGC
1601 CCATTTAAATCTCATGGGTTCTATTAAAAATATATATATATAGGGCCCCAATCCATTGCCATCAAATTGCCCTTGGACTT
1681 TTCCAAGGTATATTATGGGGTTTTATGCAAAATTCCAAGCTACCATGTAACTTTTTTTAACCATTTAACAAGGAGGGGGA
1761 ACTGTTTCCTACCTTCTTTACATGTTGTGCATTGTTGTGGTCCAGAAATGCCAAACCTTTTTAAAGATGGTGCAACTTTG
1841 AGTCCTTGGCTTGACTATACAGGCCTTGAACTTCATGGCATATCAACTTTGCCATATCTGCAGGAGAGCTGTTCTATAAG
1921 AAATAGCTCAGAGTTGCAAATATCACATGTGAATGATACGGTAACTTTTAAGAAATGTCTGTATTGTATTTGAAGACTGT
2001 TTGCCATAAATCTGAAATTTGAACCTATGTATTTCAATTTGGTATGCTAAAAAGTTCTGAATTAATGTAAAGTTTTTTGT
2081 TATAATATTGTAATCTCAGTTCAAAAGTTAACTGCAAATATAAAACCCAATGATTTCTATATAGTAAATTGAACTGTAAA
2161 GGTAACTTGTGTGTGATTCTGAATACATAGATAAATGTTTTTATTCCTCATGTTTTACTTTGGCTTCTATCTGAAATAGA
2241 GGTAAAATTTTACATATCAGCTTTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugguuuccgucGGGACCGUUGa 5'
                     :::||||||| 
Target 5' tctcttaattcTTTTGGCAACa 3'
 92 - 113 143.00 -10.00
2 
miRNA  3' ugguuUCCG--UCG---GGACC-GUUGa 5'
               |||:  |||   :|||| |||| 
Target 5' gttgcAGGTTAAGCTTGTCTGGTCAACa 3'
 30 - 57 123.00 -13.20
3 
miRNA  3' uggUUUCCGUCGG--GACCGUUga 5'
             ||||| :||:  || ||||  
Target 5' gggAAAGG-GGCTAGCTAGCAAag 3'
 588 - 610 112.00 -12.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30508383 13 COSMIC
COSN24302602 54 COSMIC
COSN30521329 85 COSMIC
COSN31548254 102 COSMIC
COSN30533363 171 COSMIC
COSN31513050 240 COSMIC
COSN31575881 559 COSMIC
COSN31575893 563 COSMIC
COSN31480823 701 COSMIC
COSN26481763 742 COSMIC
COSN31547513 846 COSMIC
COSN6902036 984 COSMIC
COSN24041895 1215 COSMIC
COSN22281665 1454 COSMIC
COSN31490889 1468 COSMIC
COSN31527919 1484 COSMIC
COSN22028505 1512 COSMIC
COSN31491041 1529 COSMIC
COSN31609769 1551 COSMIC
COSN28662085 1633 COSMIC
COSN31596212 1637 COSMIC
COSN31547885 1663 COSMIC
COSN31481177 1768 COSMIC
COSN30174177 1826 COSMIC
COSN31529521 2018 COSMIC
COSN16349167 2104 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763618651 4 dbSNP
rs375544784 12 dbSNP
rs200238843 13 dbSNP
rs1241429719 16 dbSNP
rs1200586035 20 dbSNP
rs981667901 25 dbSNP
rs759491354 27 dbSNP
rs769852042 33 dbSNP
rs774454737 37 dbSNP
rs771096872 39 dbSNP
rs1373139683 43 dbSNP
rs563805985 55 dbSNP
rs927104462 63 dbSNP
rs1165686031 83 dbSNP
rs1366361860 84 dbSNP
rs1419331984 85 dbSNP
rs978560207 86 dbSNP
rs867103190 91 dbSNP
rs1432081057 93 dbSNP
rs545726322 106 dbSNP
rs1020191022 108 dbSNP
rs988424286 120 dbSNP
rs988759611 127 dbSNP
rs578080863 130 dbSNP
rs1352478265 131 dbSNP
rs957047008 135 dbSNP
rs1221740759 147 dbSNP
rs1286064297 151 dbSNP
rs1032698549 154 dbSNP
rs1228407486 161 dbSNP
rs954505869 163 dbSNP
rs1030035853 164 dbSNP
rs1006596679 166 dbSNP
rs1462605795 168 dbSNP
rs570208461 171 dbSNP
rs889594074 174 dbSNP
rs1469773740 176 dbSNP
rs878917881 178 dbSNP
rs1413457605 183 dbSNP
rs879450499 199 dbSNP
rs13265547 200 dbSNP
rs17775790 201 dbSNP
rs752128520 203 dbSNP
rs897043147 207 dbSNP
rs1036978491 210 dbSNP
rs540696820 213 dbSNP
rs17775779 223 dbSNP
rs767279002 225 dbSNP
rs776212067 235 dbSNP
rs555079813 240 dbSNP
rs763616540 241 dbSNP
rs927440885 248 dbSNP
rs1005651490 255 dbSNP
rs561375734 256 dbSNP
rs1047750391 274 dbSNP
rs536630170 276 dbSNP
rs1218364886 280 dbSNP
rs1261025415 293 dbSNP
rs1406095523 299 dbSNP
rs895802480 301 dbSNP
rs1204246474 302 dbSNP
rs757158655 316 dbSNP
rs913458318 326 dbSNP
rs1179921713 327 dbSNP
rs989039495 332 dbSNP
rs1162772454 334 dbSNP
rs1473516012 335 dbSNP
rs1057167344 336 dbSNP
rs751465797 369 dbSNP
rs956996541 370 dbSNP
rs937335458 374 dbSNP
rs927325395 382 dbSNP
rs1389240403 388 dbSNP
rs1330320173 389 dbSNP
rs1317706570 396 dbSNP
rs978861313 410 dbSNP
rs1403982934 413 dbSNP
rs1281084235 416 dbSNP
rs1032647956 425 dbSNP
rs569682127 426 dbSNP
rs1467684261 430 dbSNP
rs1270705208 432 dbSNP
rs3836 435 dbSNP
rs953923840 436 dbSNP
rs1331870687 440 dbSNP
rs1337383354 441 dbSNP
rs539726943 449 dbSNP
rs565688201 450 dbSNP
rs1223585237 454 dbSNP
rs1371626494 456 dbSNP
rs1295571696 468 dbSNP
rs1437433147 476 dbSNP
rs1030668718 479 dbSNP
rs974395562 484 dbSNP
rs998412830 488 dbSNP
rs1458840241 489 dbSNP
rs1481664240 490 dbSNP
rs1200769899 503 dbSNP
rs185793677 504 dbSNP
rs763095459 508 dbSNP
rs182270813 509 dbSNP
rs1169099183 510 dbSNP
rs1396618183 517 dbSNP
rs1005483017 521 dbSNP
rs772028932 524 dbSNP
rs888401875 531 dbSNP
rs1005954010 537 dbSNP
rs1049089461 543 dbSNP
rs937382022 548 dbSNP
rs1426992113 564 dbSNP
rs1025852908 574 dbSNP
rs745793061 577 dbSNP
rs1250709458 580 dbSNP
rs896036389 594 dbSNP
rs1289945277 595 dbSNP
rs1490907146 602 dbSNP
rs1223595294 608 dbSNP
rs1464905055 611 dbSNP
rs1261506555 612 dbSNP
rs777611079 613 dbSNP
rs567746500 619 dbSNP
rs1373119485 625 dbSNP
rs1443552247 630 dbSNP
rs1161267912 632 dbSNP
rs1045829558 634 dbSNP
rs112066235 637 dbSNP
rs192260167 644 dbSNP
rs913403917 645 dbSNP
rs770912375 647 dbSNP
rs530806460 650 dbSNP
rs1383821412 658 dbSNP
rs1043151005 659 dbSNP
rs112435154 659 dbSNP
rs757008685 659 dbSNP
rs1370555651 662 dbSNP
rs1245269306 676 dbSNP
rs947490998 678 dbSNP
rs1361813836 679 dbSNP
rs1245832401 681 dbSNP
rs1301443877 686 dbSNP
rs1437369204 688 dbSNP
rs186146128 689 dbSNP
rs749258270 690 dbSNP
rs373717405 695 dbSNP
rs1461274870 702 dbSNP
rs528405299 704 dbSNP
rs933149976 719 dbSNP
rs1444841311 726 dbSNP
rs922314687 726 dbSNP
rs1361843176 728 dbSNP
rs1455204175 730 dbSNP
rs976533153 734 dbSNP
rs1433805617 736 dbSNP
rs974644634 739 dbSNP
rs964333151 744 dbSNP
rs908907178 745 dbSNP
rs961469206 750 dbSNP
rs1396797452 763 dbSNP
rs1015429183 767 dbSNP
rs950532242 778 dbSNP
rs1315494332 796 dbSNP
rs1190109541 797 dbSNP
rs1269196279 801 dbSNP
rs1323388985 810 dbSNP
rs1202378813 819 dbSNP
rs1026491594 820 dbSNP
rs994309791 839 dbSNP
rs1176250763 840 dbSNP
rs1247907013 841 dbSNP
rs960504170 842 dbSNP
rs1159518574 850 dbSNP
rs1428369555 855 dbSNP
rs1472046055 856 dbSNP
rs1449606223 861 dbSNP
rs545331773 862 dbSNP
rs1035920195 866 dbSNP
rs1005427738 867 dbSNP
rs1178552448 868 dbSNP
rs1408385024 881 dbSNP
rs1466669881 883 dbSNP
rs533702076 906 dbSNP
rs370225363 908 dbSNP
rs1033627527 914 dbSNP
rs866142285 923 dbSNP
rs1289350066 932 dbSNP
rs180917567 936 dbSNP
rs1046191038 945 dbSNP
rs1222215487 946 dbSNP
rs541213827 952 dbSNP
rs1313307706 957 dbSNP
rs1014347090 959 dbSNP
rs1347522436 967 dbSNP
rs1278535537 976 dbSNP
rs1230863495 977 dbSNP
rs1327149249 998 dbSNP
rs1481385356 1015 dbSNP
rs1182517531 1016 dbSNP
rs1267884571 1018 dbSNP
rs1294904505 1034 dbSNP
rs573926952 1048 dbSNP
rs1053214547 1049 dbSNP
rs936196868 1052 dbSNP
rs1409307397 1053 dbSNP
rs1381278979 1060 dbSNP
rs1043111833 1061 dbSNP
rs1352885924 1063 dbSNP
rs1011591117 1076 dbSNP
rs926194417 1079 dbSNP
rs1365324822 1086 dbSNP
rs891837364 1086 dbSNP
rs1050022126 1093 dbSNP
rs561446385 1099 dbSNP
rs1285584349 1103 dbSNP
rs1368864603 1107 dbSNP
rs1214527816 1108 dbSNP
rs933138872 1121 dbSNP
rs1308793315 1138 dbSNP
rs923125893 1156 dbSNP
rs1062312 1159 dbSNP
rs188129323 1161 dbSNP
rs758191382 1162 dbSNP
rs922301944 1174 dbSNP
rs976859172 1178 dbSNP
rs961114676 1180 dbSNP
rs1184750844 1182 dbSNP
rs908317649 1190 dbSNP
rs374323900 1193 dbSNP
rs531423722 1193 dbSNP
rs983944379 1198 dbSNP
rs1451469050 1205 dbSNP
rs1429967260 1208 dbSNP
rs1384764744 1210 dbSNP
rs1423005332 1212 dbSNP
rs1305285213 1213 dbSNP
rs1350885695 1214 dbSNP
rs1430610591 1219 dbSNP
rs575905523 1226 dbSNP
rs557735485 1233 dbSNP
rs952538273 1238 dbSNP
rs539322348 1242 dbSNP
rs1002128226 1244 dbSNP
rs970427488 1247 dbSNP
rs1313745322 1250 dbSNP
rs1356776806 1251 dbSNP
rs545983708 1255 dbSNP
rs1247747167 1260 dbSNP
rs1167738680 1267 dbSNP
rs1290288169 1283 dbSNP
rs1446277913 1301 dbSNP
rs572320422 1305 dbSNP
rs1243715969 1307 dbSNP
rs1465292875 1316 dbSNP
rs1424978766 1320 dbSNP
rs1384706769 1321 dbSNP
rs184234933 1323 dbSNP
rs1258873905 1334 dbSNP
rs1165264785 1335 dbSNP
rs748417844 1341 dbSNP
rs1414974900 1342 dbSNP
rs1400554554 1352 dbSNP
rs781533276 1353 dbSNP
rs1347395954 1363 dbSNP
rs1436504151 1370 dbSNP
rs1335434332 1383 dbSNP
rs1485581645 1384 dbSNP
rs1053159229 1396 dbSNP
rs1207608316 1402 dbSNP
rs1349518253 1403 dbSNP
rs1221786023 1413 dbSNP
rs1340359630 1422 dbSNP
rs1286119761 1427 dbSNP
rs2809 1432 dbSNP
rs1000290299 1436 dbSNP
rs950438219 1442 dbSNP
rs918991624 1445 dbSNP
rs1460092924 1447 dbSNP
rs535621698 1462 dbSNP
rs1050399106 1464 dbSNP
rs1323578599 1469 dbSNP
rs932911558 1481 dbSNP
rs960224729 1487 dbSNP
rs1414682917 1500 dbSNP
rs368213680 1512 dbSNP
rs1035886578 1513 dbSNP
rs922885322 1523 dbSNP
rs1040695818 1526 dbSNP
rs1403247663 1530 dbSNP
rs939699855 1532 dbSNP
rs1414071814 1540 dbSNP
rs908264746 1547 dbSNP
rs755395425 1560 dbSNP
rs1021885829 1564 dbSNP
rs931096318 1568 dbSNP
rs926483965 1571 dbSNP
rs761672605 1581 dbSNP
rs1410154711 1582 dbSNP
rs1281046412 1586 dbSNP
rs981045787 1587 dbSNP
rs796687242 1588 dbSNP
rs1261245595 1593 dbSNP
rs970665603 1600 dbSNP
rs751936244 1608 dbSNP
rs568306690 1609 dbSNP
rs1279464203 1614 dbSNP
rs1437412891 1615 dbSNP
rs1202756433 1616 dbSNP
rs956052401 1618 dbSNP
rs1031741774 1619 dbSNP
rs774131877 1623 dbSNP
rs181184371 1629 dbSNP
rs901673988 1630 dbSNP
rs1062315 1631 dbSNP
rs1395201925 1631 dbSNP
rs199990780 1632 dbSNP
rs1309545077 1633 dbSNP
rs554773226 1633 dbSNP
rs1416276155 1634 dbSNP
rs189204195 1635 dbSNP
rs1438693870 1636 dbSNP
rs775327845 1636 dbSNP
rs144154120 1639 dbSNP
rs1233910719 1643 dbSNP
rs928959760 1643 dbSNP
rs1275490891 1651 dbSNP
rs775902342 1652 dbSNP
rs1028489024 1660 dbSNP
rs1250160365 1662 dbSNP
rs918949680 1663 dbSNP
rs1194282890 1666 dbSNP
rs997447775 1672 dbSNP
rs1483506548 1678 dbSNP
rs1222158322 1679 dbSNP
rs1267237539 1680 dbSNP
rs1453806774 1681 dbSNP
rs991906469 1684 dbSNP
rs1489535590 1690 dbSNP
rs1273859513 1693 dbSNP
rs28485929 1696 dbSNP
rs980225470 1697 dbSNP
rs1301013772 1699 dbSNP
rs970230642 1700 dbSNP
rs1392679716 1705 dbSNP
rs185243020 1711 dbSNP
rs1317624852 1715 dbSNP
rs529438494 1716 dbSNP
rs193147676 1720 dbSNP
rs956047098 1723 dbSNP
rs866712897 1724 dbSNP
rs886778258 1726 dbSNP
rs1334939625 1732 dbSNP
rs1343074706 1734 dbSNP
rs543102286 1738 dbSNP
rs901902244 1739 dbSNP
rs576106948 1750 dbSNP
rs926402980 1752 dbSNP
rs1324668667 1756 dbSNP
rs544742955 1757 dbSNP
rs980610068 1761 dbSNP
rs1443611059 1772 dbSNP
rs1161325912 1776 dbSNP
rs949272258 1778 dbSNP
rs1458169406 1779 dbSNP
rs1157787099 1782 dbSNP
rs1382642689 1791 dbSNP
rs13123 1792 dbSNP
rs545767581 1814 dbSNP
rs988036048 1818 dbSNP
rs1366070521 1819 dbSNP
rs572098721 1828 dbSNP
rs897489940 1829 dbSNP
rs955999883 1835 dbSNP
rs1363563666 1838 dbSNP
rs1260541970 1842 dbSNP
rs1327642059 1848 dbSNP
rs1211177014 1849 dbSNP
rs1268175766 1854 dbSNP
rs1460542742 1858 dbSNP
rs1181228032 1863 dbSNP
rs1179979847 1871 dbSNP
rs555747278 1874 dbSNP
rs1253814517 1877 dbSNP
rs554103511 1880 dbSNP
rs1213162336 1881 dbSNP
rs1458716709 1884 dbSNP
rs1467144464 1889 dbSNP
rs978771890 1894 dbSNP
rs1056498836 1896 dbSNP
rs767404863 1898 dbSNP
rs1301174156 1904 dbSNP
rs1381569711 1906 dbSNP
rs190642869 1911 dbSNP
rs574640320 1917 dbSNP
rs556416023 1918 dbSNP
rs6921 1919 dbSNP
rs3203444 1923 dbSNP
rs901358599 1924 dbSNP
rs551613855 1929 dbSNP
rs1207364096 1940 dbSNP
rs1235091386 1943 dbSNP
rs1483359808 1946 dbSNP
rs138047141 1947 dbSNP
rs770732281 1960 dbSNP
rs1473482071 1961 dbSNP
rs1182652344 1963 dbSNP
rs1302164036 1968 dbSNP
rs1428433608 1970 dbSNP
rs1479436357 1978 dbSNP
rs1438084360 1981 dbSNP
rs745339690 1983 dbSNP
rs887391268 1985 dbSNP
rs1297890866 1999 dbSNP
rs1366726833 2004 dbSNP
rs914766869 2011 dbSNP
rs990414364 2019 dbSNP
rs1345381769 2024 dbSNP
rs1320910962 2027 dbSNP
rs1302720141 2028 dbSNP
rs1048087291 2031 dbSNP
rs1226220708 2047 dbSNP
rs565778612 2057 dbSNP
rs1483836858 2067 dbSNP
rs1205563312 2071 dbSNP
rs1267951839 2072 dbSNP
rs1031931537 2073 dbSNP
rs1436911667 2082 dbSNP
rs762969956 2082 dbSNP
rs1395928791 2083 dbSNP
rs904925887 2088 dbSNP
rs1433905953 2099 dbSNP
rs547643072 2102 dbSNP
rs553435014 2103 dbSNP
rs1431884672 2112 dbSNP
rs773142748 2116 dbSNP
rs140334150 2118 dbSNP
rs1434935401 2119 dbSNP
rs1062365 2121 dbSNP
rs897694586 2131 dbSNP
rs1193863697 2137 dbSNP
rs1056400881 2139 dbSNP
rs534500053 2159 dbSNP
rs1294811352 2161 dbSNP
rs1343800090 2169 dbSNP
rs1228754360 2173 dbSNP
rs1446392615 2176 dbSNP
rs1290719358 2186 dbSNP
rs1003180006 2188 dbSNP
rs904887562 2191 dbSNP
rs1201978291 2194 dbSNP
rs1485520111 2196 dbSNP
rs1044817297 2197 dbSNP
rs1246316470 2208 dbSNP
rs1052255522 2221 dbSNP
rs550239774 2226 dbSNP
rs1384983613 2228 dbSNP
rs796360279 2229 dbSNP
rs1167353076 2232 dbSNP
rs1350938739 2240 dbSNP
rs935247610 2241 dbSNP
rs1317937600 2257 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796040. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugguuuccgucggGACCGUUGa 5'
                       :||||||| 
Target 5' -------------UUGGCAACa 3'
 		1 - 9
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796040
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000337198.5 | 3UTR | UUGGCAACAAAAACUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
167 hsa-miR-6501-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT156859 FAM126B family with sequence similarity 126 member B 2 2
MIRT173355 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT369102 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT442037 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT442829 AZIN1 antizyme inhibitor 1 2 2
MIRT443729 CCND2 cyclin D2 2 2
MIRT453771 NUCB1 nucleobindin 1 2 10
MIRT453875 IFRD1 interferon related developmental regulator 1 2 12
MIRT454229 OSBPL10 oxysterol binding protein like 10 2 11
MIRT458829 RPUSD2 RNA pseudouridylate synthase domain containing 2 2 2
MIRT459898 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 10
MIRT464162 VMP1 vacuole membrane protein 1 2 15
MIRT495411 SMAD2 SMAD family member 2 2 2
MIRT496906 TRIM56 tripartite motif containing 56 2 2
MIRT498653 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 6
MIRT498706 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT499308 ZNF485 zinc finger protein 485 2 6
MIRT499707 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 10
MIRT499755 CIRH1A UTP4, small subunit processome component 2 6
MIRT499827 PCSK9 proprotein convertase subtilisin/kexin type 9 2 8
MIRT503691 MAVS mitochondrial antiviral signaling protein 2 2
MIRT512418 LAYN layilin 2 4
MIRT516232 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT522554 MCAM melanoma cell adhesion molecule 2 4
MIRT523760 FBXO27 F-box protein 27 2 4
MIRT525107 PRKD2 protein kinase D2 2 2
MIRT525919 KIAA0391 KIAA0391 2 2
MIRT527246 COMMD6 COMM domain containing 6 2 2
MIRT527564 ADCY7 adenylate cyclase 7 2 2
MIRT528764 CD1D CD1d molecule 2 2
MIRT529362 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT529464 ZNF546 zinc finger protein 546 2 2
MIRT530676 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531635 C19orf52 translocase of inner mitochondrial membrane 29 2 4
MIRT531909 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532172 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534234 SLC25A16 solute carrier family 25 member 16 2 4
MIRT534561 RRAGD Ras related GTP binding D 2 2
MIRT534971 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536738 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT538544 CELF1 CUGBP Elav-like family member 1 2 2
MIRT540462 ZNF71 zinc finger protein 71 2 2
MIRT540554 PPIC peptidylprolyl isomerase C 2 2
MIRT543593 KIAA1549 KIAA1549 2 2
MIRT543963 RNF20 ring finger protein 20 2 2
MIRT544047 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT544670 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT550665 TRAF1 TNF receptor associated factor 1 2 2
MIRT558540 CSNK1G3 casein kinase 1 gamma 3 2 4
MIRT574917 Vmp1 vacuole membrane protein 1 2 9
MIRT575298 Osbpl10 oxysterol binding protein-like 10 2 7
MIRT607960 SNX22 sorting nexin 22 2 2
MIRT610649 TIPRL TOR signaling pathway regulator 2 8
MIRT615899 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT617438 CCS copper chaperone for superoxide dismutase 2 2
MIRT617510 C5orf45 MRN complex interacting protein 2 2
MIRT617548 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT620565 WBSCR27 methyltransferase like 27 2 2
MIRT623166 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT624161 DGKE diacylglycerol kinase epsilon 2 2
MIRT626090 MKLN1 muskelin 1 2 2
MIRT627010 FIG4 FIG4 phosphoinositide 5-phosphatase 2 2
MIRT627073 SF3A1 splicing factor 3a subunit 1 2 2
MIRT627136 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT627340 TSHZ2 teashirt zinc finger homeobox 2 2 2
MIRT627436 TAS2R5 taste 2 receptor member 5 2 2
MIRT628273 CYB5D1 cytochrome b5 domain containing 1 2 2
MIRT629091 F2RL1 F2R like trypsin receptor 1 2 4
MIRT629282 UNC13A unc-13 homolog A 2 2
MIRT630122 ARHGEF5 Rho guanine nucleotide exchange factor 5 2 2
MIRT630247 SMTNL2 smoothelin like 2 2 2
MIRT631260 CENPM centromere protein M 2 2
MIRT631336 CD300E CD300e molecule 2 2
MIRT631399 IL2RA interleukin 2 receptor subunit alpha 2 2
MIRT632593 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT632991 DUSP18 dual specificity phosphatase 18 2 2
MIRT633079 CXorf21 chromosome X open reading frame 21 2 2
MIRT634223 TMEM132B transmembrane protein 132B 2 2
MIRT635046 MYH11 myosin heavy chain 11 2 2
MIRT636444 LRCH3 leucine rich repeats and calponin homology domain containing 3 2 2
MIRT636649 CDK4 cyclin dependent kinase 4 2 2
MIRT637129 BAMBI BMP and activin membrane bound inhibitor 2 2
MIRT637282 IBA57 IBA57 homolog, iron-sulfur cluster assembly 2 2
MIRT637527 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT637783 OLA1 Obg like ATPase 1 2 2
MIRT637920 LILRA2 leukocyte immunoglobulin like receptor A2 2 2
MIRT638238 SLC1A5 solute carrier family 1 member 5 2 2
MIRT638444 PLXDC2 plexin domain containing 2 2 2
MIRT639765 GPR45 G protein-coupled receptor 45 2 2
MIRT640437 ERVMER34-1 endogenous retrovirus group MER34 member 1, envelope 2 2
MIRT643006 ZNF829 zinc finger protein 829 2 2
MIRT644233 SLC35E3 solute carrier family 35 member E3 2 2
MIRT644661 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644957 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT645086 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT645256 DFFA DNA fragmentation factor subunit alpha 2 2
MIRT645861 GBP6 guanylate binding protein family member 6 2 2
MIRT645987 ACP6 acid phosphatase 6, lysophosphatidic 2 2
MIRT646502 FAM217B family with sequence similarity 217 member B 2 2
MIRT646811 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647706 NFX1 nuclear transcription factor, X-box binding 1 2 2
MIRT649657 TEP1 telomerase associated protein 1 2 2
MIRT650550 YIPF4 Yip1 domain family member 4 2 2
MIRT650785 GSR glutathione-disulfide reductase 2 2
MIRT651461 XIAP X-linked inhibitor of apoptosis 2 2
MIRT652098 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT654117 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT658901 DPY19L4 dpy-19 like 4 2 2
MIRT659370 CREG2 cellular repressor of E1A stimulated genes 2 2 2
MIRT662537 MTAP methylthioadenosine phosphorylase 2 2
MIRT662617 MCM8 minichromosome maintenance 8 homologous recombination repair factor 2 2
MIRT663491 IYD iodotyrosine deiodinase 2 2
MIRT663899 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT664552 MKI67IP nucleolar protein interacting with the FHA domain of MKI67 1 1
MIRT664582 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT664953 PTCD3 pentatricopeptide repeat domain 3 2 2
MIRT665193 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 2
MIRT665446 WDR17 WD repeat domain 17 2 2
MIRT665894 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT666480 SBNO1 strawberry notch homolog 1 2 2
MIRT666514 RNF170 ring finger protein 170 2 2
MIRT666692 RBM23 RNA binding motif protein 23 2 2
MIRT666791 PSMD1 proteasome 26S subunit, non-ATPase 1 2 2
MIRT667453 MAPK14 mitogen-activated protein kinase 14 2 2
MIRT667553 LRAT lecithin retinol acyltransferase 2 4
MIRT667744 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT668080 GMEB1 glucocorticoid modulatory element binding protein 1 2 2
MIRT668114 GK5 glycerol kinase 5 (putative) 2 2
MIRT668501 ESYT2 extended synaptotagmin 2 2 2
MIRT668942 CNKSR3 CNKSR family member 3 2 2
MIRT670408 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT671134 CD226 CD226 molecule 2 2
MIRT671919 PLEKHS1 pleckstrin homology domain containing S1 2 4
MIRT672287 GP2 glycoprotein 2 2 2
MIRT672427 POLR2D RNA polymerase II subunit D 2 2
MIRT672762 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT672923 LRRC2 leucine rich repeat containing 2 2 2
MIRT673150 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT673309 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT673560 PLA2G16 phospholipase A2 group XVI 2 2
MIRT673895 DCTN6 dynactin subunit 6 2 2
MIRT674513 PRR23A proline rich 23A 2 2
MIRT674614 RBBP4 RB binding protein 4, chromatin remodeling factor 2 2
MIRT674747 SLC16A1 solute carrier family 16 member 1 2 2
MIRT675693 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT675890 SNAP29 synaptosome associated protein 29 2 2
MIRT685271 KIAA1143 KIAA1143 2 2
MIRT686057 KCNA7 potassium voltage-gated channel subfamily A member 7 2 2
MIRT693886 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT695594 TMEM199 transmembrane protein 199 2 2
MIRT696592 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT698041 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT699907 RUNDC1 RUN domain containing 1 2 2
MIRT706608 CYB5B cytochrome b5 type B 2 2
MIRT706628 PNPT1 polyribonucleotide nucleotidyltransferase 1 2 2
MIRT706640 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT706676 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT706723 RFK riboflavin kinase 2 2
MIRT706857 MAFF MAF bZIP transcription factor F 2 2
MIRT706891 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT706958 FANCC Fanconi anemia complementation group C 2 2
MIRT706976 XPO5 exportin 5 2 2
MIRT707010 RRP36 ribosomal RNA processing 36 2 2
MIRT707028 ACTR5 ARP5 actin related protein 5 homolog 2 2
MIRT707068 MED29 mediator complex subunit 29 2 2
MIRT713253 ZFP30 ZFP30 zinc finger protein 2 2
MIRT719130 NR2F6 nuclear receptor subfamily 2 group F member 6 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-6501 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-6501-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6501-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6501-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6501-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6501-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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