miRTarBase - #MIRT443097


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pre-miRNA Information
pre-miRNA hsa-mir-921   
Genomic Coordinates chr1: 166154743 - 166154798
Synonyms MIRN921, hsa-mir-921, MIR921
Description Homo sapiens miR-921 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-921
Sequence 2| CUAGUGAGGGACAGAACCAGGAUUC |26
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31549221 11 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1464259216 3 dbSNP
rs768428855 8 dbSNP
rs746970999 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RNF20   
Synonyms BRE1, BRE1A, hBRE1
Description ring finger protein 20
Transcript NM_019592   
Expression
Putative miRNA Targets on RNF20
3'UTR of RNF20
(miRNA target sites are highlighted)		 
>RNF20|NM_019592|3'UTR
   1 TCTAAGTCAAGAGAAGAAGAGGAGCTGGCTAGTCAGGAACTTATTCATTAACCACCAAACCTCTACCTCTTCTCTCCTTG
  81 ACTGTCACCTGTAGGACAGTTTATCAGTCAACTACCTTTCCTCCAGACTTTACTTCCAGGCTCTCCTCTTCAGTAGCTGG
 161 ATGACTTTAGCAGAAAGGACTGGTAAATACAAGCCTTGGGTTTCAGAATGAATTAGAAACAAATAACTCTTACTGTCTTC
 241 CCTCCCAGCTTTGTTTATTTTGTGCTTTTAGACTTTTCAGTGTTTTCTTTTTCCAGCCCACTGTATAAACTTGGATTGTC
 321 CATTCCTCCTGAAGAAATCAAGTTGGTATTTTTGATGTGGAAAAGGGAACAAAAGTGGAAACATGGCTACTTTTGGGGAG
 401 TGATATTTTAAAAAATAAGTTGTCTATGGGCACAAAGTTTTCTTCATTTGTGTAGCAAACTTCTTGTGAATGTGGATTAC
 481 AAAATGGTATAATTGTGCTACTCTCCCCTGGGTGGTTTGCAGCCCTAATGAAATTATGTCTAGGATGATTCAGTCTATTT
 561 CCCATTTACTAGCAGAGTAACTTGTTAAGATCAGCTGGCTTTCTTGTTAAAGTTATTTAAGTTTTGAATGCTCTACTACT
 641 TCAAGTCTTTAAATTTCTTGAGACTAGAATAATTTTAAATAATATGACCCTTTGTCTTCTAATGAAATAAAGATTGAAGA
 721 GGTTGAGTCAGGACTGAGCTGGTGAAGAAATCTTGTGGGTATTCTGGAAATTTGATACGGAGAGAACTTGGTGAGCTATG
 801 AATTACTCTCAGTCTCCTTTTTACAGGGTTGTTGTGATCCCTCTTTTCCAGAAAATTCTGTGGAATGTTTCTGTAGGACT
 881 TTGTTCTCCACAAGCTTGAATTAAAGCAGGATTCAGTTTGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUAGGACCAAGACAGG--GAGUGAUc 5'
            ||:| |  | | |||  :|:|||| 
Target 5' tgATTCAGTCTATTTCCCATTTACTAg 3'
 546 - 572 129.00 -13.70
2 
miRNA  3' cuUAGGACCAAGAC-AGGGAG-UGAUc 5'
            ||::  |||:||  : ||| |||| 
Target 5' ttATTTAAGTTTTGAATGCTCTACTAc 3'
 613 - 639 127.00 -8.90
3 
miRNA  3' cuuAGGACCAAGACAGGGAGUGAUc 5'
             ||| || |||  :|:||| || 
Target 5' actTCCAGGCTCTCCTCTTCAGTAg 3'
 132 - 156 126.00 -17.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30106288 48 COSMIC
COSN31539066 80 COSMIC
COSN31517941 249 COSMIC
COSN28734127 490 COSMIC
COSN20824218 557 COSMIC
COSN2302094 629 COSMIC
COSN5693737 698 COSMIC
COSN31537523 759 COSMIC
COSN31534360 813 COSMIC
rs41282153 499 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1428016962 2 dbSNP
rs763541292 11 dbSNP
rs1275071677 15 dbSNP
rs767455382 16 dbSNP
rs998770268 21 dbSNP
rs766761004 22 dbSNP
rs370109051 25 dbSNP
rs1326570709 30 dbSNP
rs758943814 31 dbSNP
rs767333333 36 dbSNP
rs200826503 40 dbSNP
rs12238569 42 dbSNP
rs1283475904 44 dbSNP
rs763992624 45 dbSNP
rs1244898453 54 dbSNP
rs997036921 57 dbSNP
rs1367016006 61 dbSNP
rs915210573 64 dbSNP
rs1408821152 73 dbSNP
rs948081100 82 dbSNP
rs1308980939 83 dbSNP
rs1045552615 84 dbSNP
rs1412297992 88 dbSNP
rs1163129581 96 dbSNP
rs1028085819 103 dbSNP
rs560975176 107 dbSNP
rs374623182 118 dbSNP
rs1227614072 122 dbSNP
rs1472374963 138 dbSNP
rs1252325038 141 dbSNP
rs1206389066 143 dbSNP
rs986476576 144 dbSNP
rs752524419 147 dbSNP
rs755679443 153 dbSNP
rs374768172 154 dbSNP
rs777111697 159 dbSNP
rs114799174 160 dbSNP
rs753572325 163 dbSNP
rs938201704 169 dbSNP
rs1350765236 181 dbSNP
rs1055181033 186 dbSNP
rs1444836016 189 dbSNP
rs1348435299 190 dbSNP
rs1323560053 201 dbSNP
rs918019569 224 dbSNP
rs1406448176 225 dbSNP
rs41282151 231 dbSNP
rs1432144475 243 dbSNP
rs1016138637 263 dbSNP
rs1456727966 266 dbSNP
rs1471878424 277 dbSNP
rs778646023 281 dbSNP
rs751317124 294 dbSNP
rs1245896862 300 dbSNP
rs1199551009 301 dbSNP
rs1469737073 320 dbSNP
rs1266118552 322 dbSNP
rs1207585804 323 dbSNP
rs1402745631 326 dbSNP
rs1285922903 329 dbSNP
rs1217115077 334 dbSNP
rs532290994 341 dbSNP
rs1274608984 346 dbSNP
rs1437859321 349 dbSNP
rs747394566 359 dbSNP
rs1029148647 365 dbSNP
rs149176227 369 dbSNP
rs1389461363 384 dbSNP
rs769095635 387 dbSNP
rs987647437 394 dbSNP
rs1412958120 396 dbSNP
rs1424247050 398 dbSNP
rs1405690758 399 dbSNP
rs1054373658 406 dbSNP
rs571282070 411 dbSNP
rs192466252 418 dbSNP
rs1246134698 421 dbSNP
rs1441433230 427 dbSNP
rs1187783020 431 dbSNP
rs893011008 451 dbSNP
rs1465012276 454 dbSNP
rs1243333238 465 dbSNP
rs1207650296 471 dbSNP
rs924075168 473 dbSNP
rs996686210 476 dbSNP
rs956864128 478 dbSNP
rs1028129791 493 dbSNP
rs41282153 499 dbSNP
rs532114667 500 dbSNP
rs567642316 503 dbSNP
rs1007960108 506 dbSNP
rs1015305096 508 dbSNP
rs1366082215 509 dbSNP
rs1290674170 511 dbSNP
rs1288773346 513 dbSNP
rs1358822261 515 dbSNP
rs948040804 522 dbSNP
rs1335037658 528 dbSNP
rs1436363774 534 dbSNP
rs1045100455 543 dbSNP
rs1167951608 556 dbSNP
rs536797834 558 dbSNP
rs1449983312 573 dbSNP
rs767715178 576 dbSNP
rs928019585 602 dbSNP
rs1224122093 606 dbSNP
rs939427613 607 dbSNP
rs1482617175 613 dbSNP
rs1237699109 616 dbSNP
rs974113184 617 dbSNP
rs1047142716 628 dbSNP
rs1482415401 637 dbSNP
rs556457394 647 dbSNP
rs867993421 648 dbSNP
rs576609657 658 dbSNP
rs1308627695 677 dbSNP
rs1298303067 683 dbSNP
rs545342134 701 dbSNP
rs1471399568 704 dbSNP
rs1161817679 711 dbSNP
rs1313792029 715 dbSNP
rs1416845007 719 dbSNP
rs959866517 725 dbSNP
rs559314372 729 dbSNP
rs990962356 730 dbSNP
rs1368803463 735 dbSNP
rs899112283 735 dbSNP
rs996229129 742 dbSNP
rs748571846 745 dbSNP
rs1409380561 747 dbSNP
rs1413868138 747 dbSNP
rs1189687397 767 dbSNP
rs572030625 779 dbSNP
rs949495197 780 dbSNP
rs142403577 784 dbSNP
rs1481129374 789 dbSNP
rs560913766 792 dbSNP
rs762306209 796 dbSNP
rs923972953 799 dbSNP
rs1220004998 810 dbSNP
rs773152930 811 dbSNP
rs1054160194 814 dbSNP
rs1321261195 827 dbSNP
rs1293963831 828 dbSNP
rs1235414690 833 dbSNP
rs893073893 836 dbSNP
rs932540586 837 dbSNP
rs1287910922 849 dbSNP
rs1030758071 859 dbSNP
rs1383202076 859 dbSNP
rs1375252372 868 dbSNP
rs1291773707 878 dbSNP
rs1247744430 883 dbSNP
rs1457323303 885 dbSNP
rs1350000428 892 dbSNP
rs529733277 897 dbSNP
rs1166504197 907 dbSNP
rs1455137389 908 dbSNP
rs1049609940 921 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuagGACCAAGACAGGGAGUGAUc 5'
               :|||  || ||:||||||| 
Target 5' -----UUGG--CU-UCUCUCACUAc 3'
 		1 - 17
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000389120.3 | 3UTR | UUGGCUUCUCUCACUACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.448 1.0e-4 -0.278 1.3e-2 64 Click to see details
GSE28260 Renal cortex and medulla 0.799 5.3e-4 0.654 7.7e-3 13 Click to see details
GSE38226 Liver fibrosis -0.534 6.3e-3 -0.494 1.1e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.335 5.9e-2 0.372 4.0e-2 23 Click to see details
GSE26953 Aortic valvular endothelial cells 0.268 1.0e-1 0.229 1.4e-1 24 Click to see details
GSE28544 Breast cancer -0.199 1.8e-1 -0.239 1.3e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.153 2.0e-1 -0.029 4.4e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.165 2.2e-1 0.051 4.0e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.045 4.3e-1 -0.511 1.1e-2 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.034 4.4e-1 -0.101 3.4e-1 20 Click to see details
GSE19783 ER- ER- breast cancer -0.012 4.6e-1 -0.072 2.6e-1 79 Click to see details
GSE19350 CNS germ cell tumors -0.028 4.7e-1 -0.175 2.9e-1 12 Click to see details
GSE19536 Breast cancer -0.006 4.8e-1 -0.039 3.5e-1 100 Click to see details
GSE19536 Breast cancer -0.006 4.8e-1 -0.039 3.5e-1 100 Click to see details
GSE19536 Breast cancer -0.006 4.8e-1 -0.039 3.5e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
63 hsa-miR-921 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT054764 ANGPTL1 angiopoietin like 1 3 1
MIRT066171 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT069409 ZFYVE21 zinc finger FYVE-type containing 21 2 8
MIRT102284 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 4
MIRT107595 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 6
MIRT178618 HIAT1 major facilitator superfamily domain containing 14A 2 2
MIRT182407 TIPRL TOR signaling pathway regulator 2 4
MIRT186552 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT273662 HOXC8 homeobox C8 2 2
MIRT283191 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT284890 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT347670 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT400222 SLC35F6 solute carrier family 35 member F6 2 2
MIRT403517 ASPH aspartate beta-hydroxylase 2 2
MIRT442251 DCTN5 dynactin subunit 5 2 2
MIRT443023 SDR39U1 short chain dehydrogenase/reductase family 39U member 1 2 2
MIRT443097 RNF20 ring finger protein 20 2 2
MIRT444560 TRA2B transformer 2 beta homolog 2 2
MIRT445696 PRKG1 protein kinase, cGMP-dependent, type I 2 2
MIRT454084 TMEM209 transmembrane protein 209 2 2
MIRT455463 LYPLA2 lysophospholipase II 2 2
MIRT456653 TIFA TRAF interacting protein with forkhead associated domain 2 2
MIRT458147 LYRM4 LYR motif containing 4 2 6
MIRT467073 SRRD SRR1 domain containing 2 4
MIRT467245 SPPL2A signal peptide peptidase like 2A 2 2
MIRT468246 SFXN4 sideroflexin 4 2 2
MIRT471589 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT476639 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT482433 ADM adrenomedullin 2 10
MIRT486848 PERP PERP, TP53 apoptosis effector 2 6
MIRT489656 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT493441 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT493841 FOXN3 forkhead box N3 2 4
MIRT501378 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT509679 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT510280 MED28 mediator complex subunit 28 2 2
MIRT512221 ATXN3 ataxin 3 2 6
MIRT514030 BNIP2 BCL2 interacting protein 2 2 2
MIRT521375 RDX radixin 2 4
MIRT521444 RAD51 RAD51 recombinase 2 2
MIRT526055 CBR1 carbonyl reductase 1 2 2
MIRT528658 FUNDC2 FUN14 domain containing 2 2 2
MIRT529975 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT544098 IPMK inositol polyphosphate multikinase 2 2
MIRT545579 SNRPA1 small nuclear ribonucleoprotein polypeptide A' 2 2
MIRT547424 MED4 mediator complex subunit 4 2 2
MIRT548955 CD2AP CD2 associated protein 2 2
MIRT549537 NDUFA6 NADH:ubiquinone oxidoreductase subunit A6 2 4
MIRT552550 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554640 ROBO1 roundabout guidance receptor 1 2 2
MIRT564904 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 2
MIRT565578 SLC6A8 solute carrier family 6 member 8 2 2
MIRT568312 BAG4 BCL2 associated athanogene 4 2 2
MIRT617891 PTCHD3 patched domain containing 3 2 2
MIRT621892 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT642850 RNF135 ring finger protein 135 2 2
MIRT665395 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT697879 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT698492 THOC2 THO complex 2 2 2
MIRT701227 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT701872 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT707045 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT715216 NPVF neuropeptide VF precursor 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-921 Progesterone approved 5994 Microarray Breast cancer 22330642 2012 up-regulated
miR-921 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-921 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-mir-921 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-921 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (KYSE)
hsa-mir-921 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-miR-921 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-921 Doxorubicin 31703 NSC123127 approved resistant cell line (HS578T)
hsa-miR-921 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-921 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Ethanol+Tamoxifen resistant cell line (LY2)
hsa-miR-921 Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-921 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-921 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-921 Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-miR-921 Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-921 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)
hsa-miR-921 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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