miRTarBase - #MIRT443284


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pre-miRNA Information
pre-miRNA hsa-mir-3194   
Genomic Coordinates chr20: 51452905 - 51452977
Description Homo sapiens miR-3194 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3194-5p
Sequence 10| GGCCAGCCACCAGGAGGGCUG |30
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1344875175 4 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZC3H12A   
Synonyms MCPIP, MCPIP-1, MCPIP1, Reg1, dJ423B22.1
Description zinc finger CCCH-type containing 12A
Transcript NM_025079   
Expression
Putative miRNA Targets on ZC3H12A
3'UTR of ZC3H12A
(miRNA target sites are highlighted)		 
>ZC3H12A|NM_025079|3'UTR
   1 GCTGCCTGTGGCTGGCAAGGGCAGCACCCCCAGCCTCCAAGGGCCGTCAGGCTGGGCTTTGGGCCATTGAGCAGCCCATT
  81 CCCAGCCCTGAGGCCCACCCCAGAGGCTGGACAGAGGGAGGATTCAAGTCGGGAAGGAAACCCACAAACCAAAGATACTG
 161 TAGGATTGGTTCTGGCCCATGCAGCACCTCTAGCTGTCTGCCTCAGTGGGTCAGAAGCGATCACCCTGTTGATACACATT
 241 GTATCTCTGTAGTTTAAGGAGACGCTGCCGGTAACGGCGTCGGTCCGTGGCTGAGGCCCAAACCGTCTTTTCTCTCAGAG
 321 GGTGGGGAGGGAGGTGGGGGCAGCAGAGGCCTGGGCTGGGTGCCCTGTGCACGCCACCCCACTTCCGCCCTACCCCTGGG
 401 ACGTTGGCCTTGGCTGGCTAGTTGGGCACCGTGTGCCTGCCCTCCAAGGGCCTCCTCTACGCCAATGAGGCCTCATCTGT
 481 GCTCTCGCTGGGCACGTGGCTTCATGTCAGTAAGCAAGATGCTTCTTAATAACCCACCTTCTGCCCCACTCTATTCCTTA
 561 TCCTGCTGCCCCTGTAGGGGTCAAGGGCCCTCCGTCTACACCCTCTTCTTCTCCTCCATCCTTTATTCAGAGTCATCTCG
 641 CCCTTCCCCATGGGTGGGGGAACCTGTGTTTGTTTGTGTGCACATGTAAATTTTAAATATTTTAAGCAGAAAGTCCTTAC
 721 CTCCTGTAACACATCAATAAAGTACAATCATTGTGAGCCCTTTCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gucgGGAGGACCACCGACCGg 5'
              |: ||| ||||||||| 
Target 5' ---gCTGCCT-GTGGCTGGCa 3'
 1 - 17 160.00 -23.40
2 
miRNA  3' guCGGGA---GGACC-----------ACCGACCGg 5'
            |||||   |||||           |||||||| 
Target 5' ccGCCCTACCCCTGGGACGTTGGCCTTGGCTGGCt 3'
 385 - 419 155.00 -28.00
3 
miRNA  3' guCGGG-AGGACCACCGACCgg 5'
            ||||  ||  | ||||||  
Target 5' agGCCCACCCCAGAGGCTGGac 3'
 91 - 112 135.00 -20.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30513334 24 COSMIC
COSN25838138 31 COSMIC
COSN31517437 38 COSMIC
COSN31605032 45 COSMIC
COSN20073826 46 COSMIC
COSN31519023 71 COSMIC
COSN30538324 72 COSMIC
COSN30529246 123 COSMIC
COSN30128493 141 COSMIC
COSN23014340 192 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1377885008 4 dbSNP
rs1442916232 10 dbSNP
rs1440408265 13 dbSNP
rs1303860655 15 dbSNP
rs912461661 16 dbSNP
rs1370222884 20 dbSNP
rs772958341 21 dbSNP
rs946679268 28 dbSNP
rs762964070 30 dbSNP
rs574631504 31 dbSNP
rs1204093572 32 dbSNP
rs774167500 35 dbSNP
rs199675868 36 dbSNP
rs753906858 43 dbSNP
rs371768832 46 dbSNP
rs201836892 47 dbSNP
rs3170940 51 dbSNP
rs777633519 51 dbSNP
rs369628768 52 dbSNP
rs1048096631 54 dbSNP
rs757114231 54 dbSNP
rs1222142320 57 dbSNP
rs1184869211 62 dbSNP
rs1289591571 67 dbSNP
rs780938838 68 dbSNP
rs3180364 82 dbSNP
rs1354528769 83 dbSNP
rs936996320 87 dbSNP
rs3180365 90 dbSNP
rs575314282 91 dbSNP
rs1222286597 93 dbSNP
rs891388394 95 dbSNP
rs546102310 109 dbSNP
rs1004845196 113 dbSNP
rs1275794291 113 dbSNP
rs1166149351 116 dbSNP
rs1344136063 123 dbSNP
rs1300645514 126 dbSNP
rs185618223 131 dbSNP
rs377046291 132 dbSNP
rs1157605823 133 dbSNP
rs1398608651 142 dbSNP
rs1426904000 148 dbSNP
rs1352057950 151 dbSNP
rs374662351 152 dbSNP
rs528380348 156 dbSNP
rs373963497 160 dbSNP
rs1297094736 166 dbSNP
rs1057232355 167 dbSNP
rs1411245298 169 dbSNP
rs1195797200 175 dbSNP
rs1488619837 179 dbSNP
rs961711889 180 dbSNP
rs1291265326 200 dbSNP
rs546660362 210 dbSNP
rs77186299 220 dbSNP
rs1314772444 226 dbSNP
rs1344051053 229 dbSNP
rs1374705558 244 dbSNP
rs1401149132 250 dbSNP
rs1052225 257 dbSNP
rs774764904 261 dbSNP
rs1428127068 264 dbSNP
rs904658911 265 dbSNP
rs1000380123 266 dbSNP
rs1176357199 268 dbSNP
rs1029059072 270 dbSNP
rs550363156 271 dbSNP
rs1172655911 277 dbSNP
rs1483527031 279 dbSNP
rs760086054 280 dbSNP
rs570246166 282 dbSNP
rs537219398 283 dbSNP
rs913804767 287 dbSNP
rs1209723589 288 dbSNP
rs946731731 293 dbSNP
rs1043741654 305 dbSNP
rs1260416577 305 dbSNP
rs1491287383 306 dbSNP
rs899919370 306 dbSNP
rs2174770 308 dbSNP
rs1212244848 311 dbSNP
rs1380745849 312 dbSNP
rs1019396699 318 dbSNP
rs965319929 323 dbSNP
rs973022005 324 dbSNP
rs145092946 325 dbSNP
rs570841895 331 dbSNP
rs1465981517 334 dbSNP
rs1372404976 335 dbSNP
rs1168266560 345 dbSNP
rs1425592946 347 dbSNP
rs1414635548 350 dbSNP
rs1183159644 355 dbSNP
rs1460143811 356 dbSNP
rs1240336020 365 dbSNP
rs1169187954 373 dbSNP
rs952517244 374 dbSNP
rs1390235464 380 dbSNP
rs983935052 381 dbSNP
rs368510379 386 dbSNP
rs189456134 387 dbSNP
rs937123177 388 dbSNP
rs1322935079 391 dbSNP
rs1312785034 393 dbSNP
rs1374396872 394 dbSNP
rs1244689520 395 dbSNP
rs1380081893 396 dbSNP
rs1311061186 398 dbSNP
rs370755174 403 dbSNP
rs916864037 404 dbSNP
rs574443644 407 dbSNP
rs945740643 414 dbSNP
rs1213887023 418 dbSNP
rs1041964742 420 dbSNP
rs904794869 425 dbSNP
rs980905210 431 dbSNP
rs1442903077 432 dbSNP
rs535961503 446 dbSNP
rs1278473517 452 dbSNP
rs936136132 454 dbSNP
rs987963608 455 dbSNP
rs564344352 461 dbSNP
rs1489090571 462 dbSNP
rs557149518 466 dbSNP
rs889198664 487 dbSNP
rs575675150 488 dbSNP
rs1019031582 496 dbSNP
rs376052789 497 dbSNP
rs1304581978 505 dbSNP
rs921238037 508 dbSNP
rs760326720 519 dbSNP
rs897784484 530 dbSNP
rs993525111 535 dbSNP
rs1052282 542 dbSNP
rs1368179763 547 dbSNP
rs1450793327 549 dbSNP
rs545714602 554 dbSNP
rs1025490528 561 dbSNP
rs142587998 567 dbSNP
rs1362541478 575 dbSNP
rs573222422 576 dbSNP
rs1034188360 584 dbSNP
rs1037160493 587 dbSNP
rs898758943 593 dbSNP
rs763697057 594 dbSNP
rs540486928 595 dbSNP
rs1489601487 600 dbSNP
rs1048737783 604 dbSNP
rs1367200020 609 dbSNP
rs1235118840 611 dbSNP
rs904879997 611 dbSNP
rs1312581771 617 dbSNP
rs1001861567 629 dbSNP
rs1403037324 634 dbSNP
rs796154209 638 dbSNP
rs111749716 640 dbSNP
rs112332298 640 dbSNP
rs917019114 640 dbSNP
rs945680781 643 dbSNP
rs1383042786 645 dbSNP
rs1174557354 646 dbSNP
rs977108579 654 dbSNP
rs1009404628 656 dbSNP
rs1174834719 664 dbSNP
rs1479081557 665 dbSNP
rs753369786 665 dbSNP
rs1264617240 667 dbSNP
rs550550473 667 dbSNP
rs375496656 671 dbSNP
rs561674930 671 dbSNP
rs568555585 671 dbSNP
rs1280936530 673 dbSNP
rs1262259941 676 dbSNP
rs936271441 685 dbSNP
rs954215736 688 dbSNP
rs1278819605 689 dbSNP
rs986812228 691 dbSNP
rs9136 692 dbSNP
rs1336326398 698 dbSNP
rs910671574 699 dbSNP
rs944900298 700 dbSNP
rs1335135910 708 dbSNP
rs1269340554 709 dbSNP
rs1466631437 710 dbSNP
rs1037173460 718 dbSNP
rs920070072 725 dbSNP
rs1040830150 730 dbSNP
rs897926458 736 dbSNP
rs769444093 738 dbSNP
rs1461483542 744 dbSNP
rs931463567 748 dbSNP
rs1201513844 755 dbSNP
rs1049076862 765 dbSNP
rs888363182 767 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucgggaGGACCACCGACCGg 5'
                 |||  |||||||| 
Target 5' ---uuggCCU--UGGCUGGC- 3'
 		1 - 15
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_025079 | 3UTR | CCCCUGGGACGUUGGCCUUGGCUGGCUAGUUGGGCACCGUGUGCCUGCCCUCCAAGGGCCUCCUCUACGCCAAUGAGGCCUCAUCUGUGCUCUCGCUGGGCACGUGGCUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_025079 | 3UTR | CUGGCUAGUUGGGCACCGUGUGCCUGCCCUCCAAGGGCCUCCUCUACGCCAAUGAGGCCUCAUCUGUGCUCUCGCUGGGCACGUGGCUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000373087.6 | 3UTR | UUGGCCUUGGCUGGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PRAD -0.966 0.02 -1.000 0.5 4 Click to see details
UCEC -0.887 0.02 -1.000 0.5 5 Click to see details
BRCA 0.682 0.03 0.714 0.02 8 Click to see details
LUSC -0.687 0.1 -0.800 0.05 5 Click to see details
THCA 0.207 0.18 0.334 0.06 22 Click to see details
LIHC -0.19 0.19 -0.148 0.25 23 Click to see details
HNSC -0.564 0.22 -0.800 0.1 4 Click to see details
KIRP 0.377 0.31 0.400 0.3 4 Click to see details
STAD 0.157 0.33 0.152 0.34 10 Click to see details
KIRC -0.291 0.35 0.200 0.4 4 Click to see details
KICH 0.213 0.37 0.200 0.37 5 Click to see details
CHOL -0.19 0.44 -0.500 0.33 3 Click to see details
CHOL -0.19 0.44 -0.500 0.33 3 Click to see details
CHOL -0.19 0.44 -0.500 0.33 3 Click to see details
72 hsa-miR-3194-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT443250 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT443284 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT461518 EMC7 ER membrane protein complex subunit 7 2 2
MIRT466738 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT467651 SLC7A1 solute carrier family 7 member 1 2 2
MIRT472998 MRPS23 mitochondrial ribosomal protein S23 2 4
MIRT477911 DUSP2 dual specificity phosphatase 2 2 2
MIRT480853 BLCAP bladder cancer associated protein 2 2
MIRT482890 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT487295 SLC38A9 solute carrier family 38 member 9 2 2
MIRT488494 SFMBT2 Scm like with four mbt domains 2 2 4
MIRT489060 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT491209 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT491479 APC2 APC2, WNT signaling pathway regulator 2 8
MIRT492558 PRX periaxin 2 6
MIRT495499 SLC39A2 solute carrier family 39 member 2 2 2
MIRT496578 ZNF280D zinc finger protein 280D 2 2
MIRT496840 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT497840 CHD1 chromodomain helicase DNA binding protein 1 2 2
MIRT499396 PLCG2 phospholipase C gamma 2 2 7
MIRT503237 C16orf74 chromosome 16 open reading frame 74 2 4
MIRT512345 ZNF665 zinc finger protein 665 2 4
MIRT512527 ATCAY ATCAY, caytaxin 2 4
MIRT513160 PPIB peptidylprolyl isomerase B 2 2
MIRT514493 STOML1 stomatin like 1 2 2
MIRT517164 SLC28A1 solute carrier family 28 member 1 2 2
MIRT520463 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT524151 DIP2A disco interacting protein 2 homolog A 2 2
MIRT530324 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT533747 TMEM184B transmembrane protein 184B 2 2
MIRT534259 SLC12A7 solute carrier family 12 member 7 2 2
MIRT561273 ZDHHC18 zinc finger DHHC-type containing 18 2 2
MIRT569126 TMC5 transmembrane channel like 5 2 4
MIRT569937 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT570073 VPS8 VPS8, CORVET complex subunit 2 2
MIRT570636 KLF13 Kruppel like factor 13 2 2
MIRT571026 CENPP centromere protein P 2 2
MIRT573838 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT574899 Plcg2 phospholipase C, gamma 2 2 5
MIRT576070 Poteg POTE ankyrin domain family, member G 2 2
MIRT576753 Tmem127 transmembrane protein 127 2 2
MIRT611795 WNT9A Wnt family member 9A 2 2
MIRT616756 SVOP SV2 related protein 2 2
MIRT630965 NGDN neuroguidin 2 2
MIRT634555 LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2 2
MIRT638646 GK5 glycerol kinase 5 (putative) 2 2
MIRT639903 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT640529 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT644529 TMEM134 transmembrane protein 134 2 2
MIRT644887 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647729 CXCR2 C-X-C motif chemokine receptor 2 2 2
MIRT648086 FAM192A family with sequence similarity 192 member A 2 2
MIRT650808 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT660505 ARPC2 actin related protein 2/3 complex subunit 2 2 2
MIRT667193 NODAL nodal growth differentiation factor 2 2
MIRT685675 PSMB7 proteasome subunit beta 7 2 2
MIRT692710 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT693598 SLC39A1 solute carrier family 39 member 1 2 2
MIRT698059 TRIOBP TRIO and F-actin binding protein 2 2
MIRT698292 TMEM2 transmembrane protein 2 2 2
MIRT702353 KLHL26 kelch like family member 26 2 2
MIRT708623 NUDT18 nudix hydrolase 18 2 2
MIRT714289 KBTBD11 kelch repeat and BTB domain containing 11 2 2
MIRT714577 WDR41 WD repeat domain 41 2 2
MIRT716734 APOL6 apolipoprotein L6 2 2
MIRT718781 RAC3 Rac family small GTPase 3 2 2
MIRT720973 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT720986 TOM1 target of myb1 membrane trafficking protein 2 2
MIRT721391 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT722905 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT723205 ZNRF1 zinc and ring finger 1 2 2
MIRT725431 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3194 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3194 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-3194 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-3194 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3194-5p Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3194-5p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3194-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-3194-5p Temozolomide 5394 NSC362856 approved resistant High Glioblastoma cell line (A172)
hsa-miR-3194-5p Estradiol 5757 NSC9895 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-3194-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3194-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3194-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-3194-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-3194-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-3194-5p Platinum 23939 resistant tissue
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-3194-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-3194-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)
hsa-miR-3194-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)

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