miRTarBase - #MIRT443415


—
pre-miRNA Information
pre-miRNA hsa-mir-5189   
Genomic Coordinates chr16: 88468918 - 88469031
Description Homo sapiens miR-5189 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5189-3p
Sequence 67| UGCCAACCGUCAGAGCCCAGA |87
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN6648174 16 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1231393102 3 dbSNP
rs755177359 8 dbSNP
rs80296158 9 dbSNP
rs1359410244 13 dbSNP
rs35613341 16 dbSNP
Putative Targets

Gene Information
Gene Symbol HOXA1   
Synonyms BSAS, HOX1, HOX1F
Description homeobox A1
Transcript NM_153620   
Other Transcripts NM_005522   
Expression
Putative miRNA Targets on HOXA1
3'UTR of HOXA1
(miRNA target sites are highlighted)		 
>HOXA1|NM_153620|3'UTR
   1 CTGGATGAAAGTCAAAAGAAACCCTCCCAAAACAGGGAAAGTTGGAGAGTACGGCTACCTGGGTCAACCCAACGCGGTGC
  81 GCACCAACTTCACTACCAAGCAGCTCACGGAACTGGAGAAGGAGTTCCACTTCAACAAGTACCTGACGCGCGCCCGCAGG
 161 GTGGAGATCGCTGCATCCCTGCAGCTCAACGAGACCCAAGTGAAGATCTGGTTCCAGAACCGCCGAATGAAGCAAAAGAA
 241 ACGTGAGAAGGAGGGTCTCTTGCCCATCTCTCCGGCCACCCCGCCAGGAAACGACGAGAAGGCCGAGGAATCCTCAGAGA
 321 AGTCCAGCTCTTCGCCCTGCGTTCCTTCCCCGGGGTCTTCTACCTCAGACACTCTGACTACCTCCCACTGAGGCGGCTCC
 401 AGCCCCAGACAACAGCCCAGGCATCTCCTTGGGCTGGGACTTCTTACCCAAAGCACATGCTTAGCTTATCTTTCTTTCCA
 481 TTTACAGTCTCTTTCTTCCTTTCTAATCCTATCTGGGGAGCTCCTGGCCAGGATAATATATTTGCAGATAATTCTGGACC
 561 AGAGACTTGGTGCGGGGTTAACACCTTCATCCAGATTGGGTGCCAGCATACATTTTCTGGTGGGCCTTAACATCCCTCCT
 641 GCTTTTAGGAGAATTCACAGAACCTACTGTTCCTTTCAGATGACCTTTTGGAAAATAGTTCCCTTTGCCAACAGAAACAT
 721 GCCAGAAGGAATCTTCTCATCTTTTATCTAACTATATGTACAGCTCTCCCCTCCCTTGTCCTTGAAAGTAGGATATAGCG
 801 AAAGGCGAGTCCAGGAGCTCAGGAAGAAGAGATGCACTATATGTTTACACAATTAATTCATCCCTTAATTTAAGTCATTT
 881 TCATGTGTGTGAGTTTGCTGGTTGTAAATACTTTGTCCTAAGAGATTTATCTTTATACAGATTTTCTAGAAATGTTTAGG
 961 TTACTAAAACAGGGTGGGCAAACTCTCTAAACTGGTACAATTTTATAGGTGAAAGAAAAAATTCCCTCATTTAAACCCAA
1041 TCAGATGCCTCAGAGGGTAGCCTTGATTTGTTCTTACAGTTAAGAAGCCCTGCAGAGCACAAACTTCAGAAACCCGGCTT
1121 CCTGTGCTAAGTCTTTCCCAATCTCTACCCCTTTCTTCTCGGGCCACCCTCTGTTTAAAATTTGTGCTGGGTTATTCAGA
1201 ACCTAAAAGTATTATTCAAACCAATTTCTTCCTTCCACAGTTATCTTAGCTGGATATAATGTATTTTCAGCTCAATTGTT
1281 AATGTGATGGATGGCACAATGAATGTATATTTTGTGTTATTCGTGAATAGTCTTTTGCATGTCGCACAATGTTTGATGTC
1361 CCCAAAGTACCACACTGAGTTCTATCAGTTATCCTTTGTGAGCCTATGATATTCCCCATTTCCTGTACAATCATGAACAG
1441 CTCTGAGATCCTGGAGTGATATGATCCAGAGCAGAGTTTACGGGTCTTAGGATGTCTGTAATAAATAAATATACTCAAGT
1521 TTCAGGTATGCTTAAGCATCCGTGTATTTGGCTGGGCTACAATTTGTTAATTCCTATGAAGTTGGCACATTTCATGAGGG
1601 GAAAGGGAGAAGGGTGGTAAATATTTTCAAAGAGATGGGCCTTTTCTTGAATAAAAGTTAATAACAGCTCCTTTATTATA
1681 ATCAAAGCTCATAATGGAAAAAAAGACTGATGAAGAAATTTATGAAGCAGATTTATTTTTGAAACAAACATGGATACTTC
1761 CTGGGTCAAGTGCTAACCTTTTCACCTCCAACTGGATGTTGACGTATATATAAACAGAACTCCCTTCAAAAGCCAAAAAA
1841 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agacccgAGACUGCCAACCGu 5'
                 | |||:|| |||| 
Target 5' ttgttaaTGTGATGGATGGCa 3'
 1276 - 1296 126.00 -16.30
2 
miRNA  3' agacccGAGACUGCCAACCGu 5'
                || |||  |||||| 
Target 5' taattcCTATGA-AGTTGGCa 3'
 1568 - 1587 122.00 -12.60
3 
miRNA  3' agACCCGAGACUGCCAACcgu 5'
            || | |:|| :|||||   
Target 5' tgTGAG-TTTGCTGGTTGtaa 3'
 888 - 907 118.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
359957 489 ClinVar
729844 524 ClinVar
287899 532 ClinVar
910289 534 ClinVar
359956 539 ClinVar
589311 562 ClinVar
359955 589 ClinVar
588637 626 ClinVar
910288 661 ClinVar
359954 673 ClinVar
589649 805 ClinVar
359953 912 ClinVar
359952 1037 ClinVar
359951 1039 ClinVar
909320 1039 ClinVar
909319 1088 ClinVar
359950 1106 ClinVar
909318 1137 ClinVar
359949 1187 ClinVar
909317 1193 ClinVar
909316 1201 ClinVar
359948 1326 ClinVar
359947 1419 ClinVar
908472 1676 ClinVar
359946 1763 ClinVar
359945 1809 ClinVar
908471 1836 ClinVar
908470 1914 ClinVar
908469 1946 ClinVar
359944 2006 ClinVar
359943 2201 ClinVar
359942 2243 ClinVar
911451 2293 ClinVar
COSM3374602 21 COSMIC
COSM8107559 23 COSMIC
COSM6109653 27 COSMIC
COSM600815 35 COSMIC
COSN30614857 119 COSMIC
COSN9984079 270 COSMIC
COSN21174020 437 COSMIC
COSN27053487 451 COSMIC
COSN30419413 474 COSMIC
COSN28869194 482 COSMIC
COSM4981562 500 COSMIC
COSM3923432 502 COSMIC
COSM7310455 514 COSMIC
COSM5746705 516 COSMIC
COSM5572447 517 COSMIC
COSM1698450 519 COSMIC
COSM8779619 526 COSMIC
COSM6681562 538 COSMIC
COSM1088835 540 COSMIC
COSM362531 541 COSMIC
COSM7930171 541 COSMIC
COSM184274 545 COSMIC
COSM3027036 546 COSMIC
COSM6339881 554 COSMIC
COSM1496628 561 COSMIC
COSM4396079 576 COSMIC
COSM3995527 581 COSMIC
COSM7544556 586 COSMIC
COSM9587011 600 COSMIC
COSM8887504 603 COSMIC
COSM5572496 606 COSMIC
COSM8979862 607 COSMIC
COSM6447468 612 COSMIC
COSM8305948 613 COSMIC
COSM746327 614 COSMIC
COSM8580553 616 COSMIC
COSM3880379 617 COSMIC
COSM7736971 618 COSMIC
COSM1088834 621 COSMIC
COSM5684236 633 COSMIC
COSM3027030 634 COSMIC
COSM3027031 634 COSMIC
COSM4155709 638 COSMIC
COSM6109654 645 COSMIC
COSM8707178 657 COSMIC
COSM7819948 662 COSMIC
COSM8147413 662 COSMIC
COSM3431523 670 COSMIC
COSM3637703 677 COSMIC
COSM452911 686 COSMIC
COSM7742847 686 COSMIC
COSM7000371 687 COSMIC
COSM3637702 688 COSMIC
COSM6681565 689 COSMIC
COSM8826830 690 COSMIC
COSM123636 699 COSMIC
COSM5884527 701 COSMIC
COSM1088833 702 COSMIC
COSM3027028 702 COSMIC
COSM329055 707 COSMIC
COSM9260889 717 COSMIC
COSM485239 725 COSMIC
COSM7983502 737 COSMIC
COSM5932062 738 COSMIC
COSM5062404 747 COSMIC
COSM5482117 748 COSMIC
COSM237522 757 COSMIC
COSM9897999 758 COSMIC
COSM1209904 761 COSMIC
COSM9732674 767 COSMIC
COSM8473041 769 COSMIC
COSM4690951 770 COSMIC
COSM9389247 773 COSMIC
COSM311834 780 COSMIC
COSM8984134 784 COSMIC
COSM1254342 793 COSMIC
COSM1088832 795 COSMIC
COSM4690950 798 COSMIC
COSM6681560 799 COSMIC
COSM7371414 801 COSMIC
COSM8495142 805 COSMIC
COSM6177257 810 COSMIC
COSM5962942 812 COSMIC
COSM5532384 813 COSMIC
COSM5532383 819 COSMIC
COSM5532386 820 COSMIC
COSM4514627 829 COSMIC
COSM6177258 837 COSMIC
COSM8268333 837 COSMIC
COSM9026581 847 COSMIC
COSM7458424 850 COSMIC
COSM7816082 851 COSMIC
COSN30504834 862 COSMIC
COSN30468493 871 COSMIC
COSN30183055 878 COSMIC
COSN30181535 880 COSMIC
COSN20041224 881 COSMIC
COSN31534985 903 COSMIC
COSN30109536 910 COSMIC
COSN30186023 910 COSMIC
COSN8516342 1187 COSMIC
COSN31535837 1216 COSMIC
COSN4868834 1223 COSMIC
COSN31484347 1249 COSMIC
COSN31517344 1276 COSMIC
COSN31481030 1294 COSMIC
COSN31528017 1310 COSMIC
COSN30543255 1442 COSMIC
COSN21258928 1625 COSMIC
COSN7976329 1655 COSMIC
COSN31577695 1703 COSMIC
COSN31549528 1732 COSMIC
COSN31557563 1751 COSMIC
COSN16731005 1765 COSMIC
COSN30174778 1820 COSMIC
COSN31541858 1882 COSMIC
COSN5099651 2002 COSMIC
COSN32200495 2074 COSMIC
COSN7976328 2159 COSMIC
COSN31589543 2269 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1202683734 5 dbSNP
rs1482506503 10 dbSNP
rs1255733961 15 dbSNP
rs1229263774 38 dbSNP
rs1331410943 40 dbSNP
rs1286534772 42 dbSNP
rs866749320 45 dbSNP
rs1227933834 48 dbSNP
rs772833336 50 dbSNP
rs183650345 56 dbSNP
rs550864825 60 dbSNP
rs1399825437 61 dbSNP
rs758098033 62 dbSNP
rs1438430533 64 dbSNP
rs1305595842 68 dbSNP
rs774113767 73 dbSNP
rs1390470284 79 dbSNP
rs1156493183 85 dbSNP
rs1368171377 86 dbSNP
rs768619999 88 dbSNP
rs1368512645 91 dbSNP
rs749125974 96 dbSNP
rs748841621 99 dbSNP
rs775263660 101 dbSNP
rs770059415 102 dbSNP
rs536977600 109 dbSNP
rs781338498 114 dbSNP
rs1272144479 120 dbSNP
rs770810383 120 dbSNP
rs1203761820 122 dbSNP
rs898975970 126 dbSNP
rs17465309 127 dbSNP
rs114515644 128 dbSNP
rs1410173230 128 dbSNP
rs888784332 128 dbSNP
rs1415931463 129 dbSNP
rs1264132826 135 dbSNP
rs1459712125 139 dbSNP
rs1205255379 143 dbSNP
rs142020905 145 dbSNP
rs923824746 150 dbSNP
rs772874166 155 dbSNP
rs1042139502 163 dbSNP
rs947389812 165 dbSNP
rs914679916 166 dbSNP
rs1227460708 170 dbSNP
rs1235557425 173 dbSNP
rs552758495 179 dbSNP
rs953424568 184 dbSNP
rs914716031 187 dbSNP
rs923460210 188 dbSNP
rs976192795 189 dbSNP
rs769364847 198 dbSNP
rs1338415962 201 dbSNP
rs1471104517 202 dbSNP
rs192550586 206 dbSNP
rs563794677 207 dbSNP
rs1175833826 211 dbSNP
rs1168308883 212 dbSNP
rs1462504705 218 dbSNP
rs1356183053 222 dbSNP
rs1409938938 224 dbSNP
rs747632154 229 dbSNP
rs1311693361 230 dbSNP
rs1015160283 232 dbSNP
rs928638321 240 dbSNP
rs1284422937 244 dbSNP
rs1375301567 245 dbSNP
rs981412262 246 dbSNP
rs1275774885 253 dbSNP
rs544078580 256 dbSNP
rs1343444365 260 dbSNP
rs951448886 267 dbSNP
rs1006341165 272 dbSNP
rs1191744522 276 dbSNP
rs74458426 277 dbSNP
rs993821715 292 dbSNP
rs1474988491 295 dbSNP
rs1023686847 303 dbSNP
rs1012004915 312 dbSNP
rs1016469881 322 dbSNP
rs1172482226 323 dbSNP
rs896210855 330 dbSNP
rs888833693 332 dbSNP
rs768343894 347 dbSNP
rs1429095606 357 dbSNP
rs1272237784 358 dbSNP
rs1366572369 362 dbSNP
rs746342260 369 dbSNP
rs1278804413 373 dbSNP
rs1350217258 382 dbSNP
rs999346191 403 dbSNP
rs902455204 412 dbSNP
rs779609688 431 dbSNP
rs757644056 432 dbSNP
rs1195883631 433 dbSNP
rs947408134 437 dbSNP
rs561337539 439 dbSNP
rs111259912 440 dbSNP
rs572556009 450 dbSNP
rs747572885 451 dbSNP
rs1285989717 453 dbSNP
rs778191046 459 dbSNP
rs758942349 460 dbSNP
rs1314290493 461 dbSNP
rs17465302 466 dbSNP
rs1383813407 469 dbSNP
rs753177962 473 dbSNP
rs1367070765 474 dbSNP
rs1322970383 479 dbSNP
rs765680274 480 dbSNP
rs576079236 482 dbSNP
rs1390860051 483 dbSNP
rs749973941 486 dbSNP
rs761281990 489 dbSNP
rs773883585 494 dbSNP
rs764089470 495 dbSNP
rs762869205 499 dbSNP
rs1234083920 500 dbSNP
rs1451772756 502 dbSNP
rs552669601 506 dbSNP
rs1192787765 507 dbSNP
rs867291429 509 dbSNP
rs923347367 515 dbSNP
rs1207189382 516 dbSNP
rs769512832 517 dbSNP
rs976248101 518 dbSNP
rs746134151 523 dbSNP
rs776669653 524 dbSNP
rs370033913 527 dbSNP
rs1465222613 528 dbSNP
rs747097748 529 dbSNP
rs34462126 532 dbSNP
rs759032142 534 dbSNP
rs779419910 539 dbSNP
rs1198964933 541 dbSNP
rs1293058993 542 dbSNP
rs1429602284 545 dbSNP
rs1397442564 548 dbSNP
rs1379213876 549 dbSNP
rs755351481 552 dbSNP
rs767117973 558 dbSNP
rs377716509 562 dbSNP
rs1364381752 570 dbSNP
rs1461286979 574 dbSNP
rs763538049 574 dbSNP
rs1451021276 578 dbSNP
rs1432125776 581 dbSNP
rs762883582 586 dbSNP
rs780133703 587 dbSNP
rs143597165 589 dbSNP
rs765041517 592 dbSNP
rs556902625 599 dbSNP
rs141900601 600 dbSNP
rs1490217901 601 dbSNP
rs771124603 603 dbSNP
rs760937523 607 dbSNP
rs772208835 608 dbSNP
rs537351255 612 dbSNP
rs138651027 613 dbSNP
rs1345441272 616 dbSNP
rs749684801 617 dbSNP
rs780457782 620 dbSNP
rs1344357835 621 dbSNP
rs183033372 625 dbSNP
rs200421049 626 dbSNP
rs777296934 627 dbSNP
rs757856016 629 dbSNP
rs960473055 631 dbSNP
rs752182067 632 dbSNP
rs1034749835 634 dbSNP
rs765197009 638 dbSNP
rs756293597 639 dbSNP
rs759512026 642 dbSNP
rs41311763 645 dbSNP
rs753632709 650 dbSNP
rs766139746 652 dbSNP
rs1482114915 653 dbSNP
rs760807570 654 dbSNP
rs1435619628 661 dbSNP
rs1167116963 666 dbSNP
rs373337108 670 dbSNP
rs886062257 673 dbSNP
rs1280426421 674 dbSNP
rs772297076 689 dbSNP
rs1424623278 698 dbSNP
rs1163231213 701 dbSNP
rs1322324732 708 dbSNP
rs1470047658 709 dbSNP
rs762030849 710 dbSNP
rs750655418 716 dbSNP
rs774571221 718 dbSNP
rs1167898544 721 dbSNP
rs144812662 722 dbSNP
rs113439849 723 dbSNP
rs375418482 727 dbSNP
rs372137447 729 dbSNP
rs770156271 730 dbSNP
rs746688404 731 dbSNP
rs1308667086 735 dbSNP
rs1469483457 737 dbSNP
rs777453698 738 dbSNP
rs1161636305 739 dbSNP
rs41303378 743 dbSNP
rs1413087993 745 dbSNP
rs1471681406 746 dbSNP
rs756302694 747 dbSNP
rs1315100953 748 dbSNP
rs752269739 748 dbSNP
rs755681153 750 dbSNP
rs1323340596 752 dbSNP
rs1176584549 756 dbSNP
rs778380747 757 dbSNP
rs1239001756 758 dbSNP
rs1201469930 763 dbSNP
rs535021244 765 dbSNP
rs754884149 769 dbSNP
rs41311760 770 dbSNP
rs1239992357 778 dbSNP
rs1199018708 787 dbSNP
rs866343256 789 dbSNP
rs1268421893 791 dbSNP
rs141025500 799 dbSNP
rs190754463 801 dbSNP
rs1314645375 802 dbSNP
rs767535281 803 dbSNP
rs750217765 805 dbSNP
rs199550475 806 dbSNP
rs1274646290 808 dbSNP
rs1313554850 811 dbSNP
rs762116573 816 dbSNP
rs889673453 817 dbSNP
rs764172712 820 dbSNP
rs757356525 821 dbSNP
rs145746454 828 dbSNP
rs763401053 829 dbSNP
rs1371876685 831 dbSNP
rs1313714052 833 dbSNP
rs776017793 834 dbSNP
rs770180375 837 dbSNP
rs1432926088 838 dbSNP
rs1304858008 839 dbSNP
rs1181655115 840 dbSNP
rs752028396 841 dbSNP
rs746273616 845 dbSNP
rs552721553 846 dbSNP
rs771768130 849 dbSNP
rs747740622 850 dbSNP
rs901977586 851 dbSNP
rs778291264 859 dbSNP
rs1322989001 860 dbSNP
rs754466672 863 dbSNP
rs749201371 864 dbSNP
rs1343358530 865 dbSNP
rs1300212279 868 dbSNP
rs780086000 871 dbSNP
rs764707296 873 dbSNP
rs756084993 875 dbSNP
rs374093898 876 dbSNP
rs1275249989 877 dbSNP
rs557199978 878 dbSNP
rs1346589537 882 dbSNP
rs1363755991 883 dbSNP
rs767366254 886 dbSNP
rs757562002 887 dbSNP
rs751796408 892 dbSNP
rs753021388 894 dbSNP
rs764103639 895 dbSNP
rs368587915 896 dbSNP
rs1191393910 897 dbSNP
rs775403241 902 dbSNP
rs56012816 912 dbSNP
rs543799175 914 dbSNP
rs1045884733 915 dbSNP
rs1178278838 917 dbSNP
rs571461216 919 dbSNP
rs1453252612 922 dbSNP
rs563885701 923 dbSNP
rs1287328509 928 dbSNP
rs1386257922 930 dbSNP
rs1436978380 934 dbSNP
rs1298290574 949 dbSNP
rs550147244 954 dbSNP
rs1216988246 956 dbSNP
rs767491682 959 dbSNP
rs985338867 962 dbSNP
rs1361664324 971 dbSNP
rs930921590 974 dbSNP
rs1237968708 975 dbSNP
rs112390813 977 dbSNP
rs1466570642 994 dbSNP
rs1180471864 999 dbSNP
rs918612354 1000 dbSNP
rs530378105 1014 dbSNP
rs1487764199 1022 dbSNP
rs1193006315 1025 dbSNP
rs1425881818 1026 dbSNP
rs561248096 1033 dbSNP
rs941356346 1034 dbSNP
rs145102625 1037 dbSNP
rs186304469 1039 dbSNP
rs1490157421 1042 dbSNP
rs751477811 1050 dbSNP
rs558956642 1063 dbSNP
rs975858846 1068 dbSNP
rs1295220169 1071 dbSNP
rs967509352 1072 dbSNP
rs1390293603 1077 dbSNP
rs1286116863 1079 dbSNP
rs886062256 1106 dbSNP
rs1019962179 1107 dbSNP
rs1011687346 1115 dbSNP
rs1277936519 1128 dbSNP
rs1224503749 1131 dbSNP
rs977842763 1134 dbSNP
rs892791377 1160 dbSNP
rs545859163 1176 dbSNP
rs1034642112 1183 dbSNP
rs1254268031 1184 dbSNP
rs886062255 1187 dbSNP
rs576914419 1193 dbSNP
rs557113073 1201 dbSNP
rs907379288 1213 dbSNP
rs1011143038 1218 dbSNP
rs1166894098 1219 dbSNP
rs1045907183 1220 dbSNP
rs889734706 1221 dbSNP
rs1349760809 1222 dbSNP
rs534787739 1222 dbSNP
rs1028195874 1228 dbSNP
rs897258489 1250 dbSNP
rs1402734933 1252 dbSNP
rs1409986459 1258 dbSNP
rs543263872 1260 dbSNP
rs1377498058 1261 dbSNP
rs1230355413 1264 dbSNP
rs1038433822 1265 dbSNP
rs901861355 1267 dbSNP
rs1203125140 1269 dbSNP
rs1276776009 1270 dbSNP
rs574740244 1271 dbSNP
rs554926387 1272 dbSNP
rs1235926368 1274 dbSNP
rs986017734 1275 dbSNP
rs1183342247 1281 dbSNP
rs1414477342 1282 dbSNP
rs1428966058 1285 dbSNP
rs143106423 1288 dbSNP
rs1371943261 1290 dbSNP
rs1429800909 1291 dbSNP
rs1311935162 1294 dbSNP
rs886492260 1302 dbSNP
rs762699252 1305 dbSNP
rs41305921 1310 dbSNP
rs1450658007 1312 dbSNP
rs1430843210 1313 dbSNP
rs1361871556 1315 dbSNP
rs1196621171 1318 dbSNP
rs923127989 1320 dbSNP
rs1343030113 1323 dbSNP
rs1210218527 1324 dbSNP
rs73683592 1326 dbSNP
rs1444296979 1327 dbSNP
rs967225227 1343 dbSNP
rs1237772147 1346 dbSNP
rs558709212 1349 dbSNP
rs1186660096 1352 dbSNP
rs1217686754 1354 dbSNP
rs1449576053 1355 dbSNP
rs1399625928 1367 dbSNP
rs930787607 1376 dbSNP
rs916876356 1382 dbSNP
rs1283285025 1386 dbSNP
rs1020477152 1387 dbSNP
rs989915839 1389 dbSNP
rs1388435191 1413 dbSNP
rs747587603 1415 dbSNP
rs117011404 1419 dbSNP
rs1265099392 1428 dbSNP
rs1233692750 1438 dbSNP
rs1366511288 1438 dbSNP
rs1273093948 1443 dbSNP
rs1347407714 1444 dbSNP
rs939549201 1446 dbSNP
rs1033984206 1454 dbSNP
rs1001790756 1459 dbSNP
rs764889039 1464 dbSNP
rs867546983 1474 dbSNP
rs907423425 1485 dbSNP
rs1024545204 1486 dbSNP
rs1301880545 1487 dbSNP
rs927633618 1487 dbSNP
rs977724757 1488 dbSNP
rs994766051 1491 dbSNP
rs753029294 1494 dbSNP
rs1456008588 1499 dbSNP
rs914957536 1502 dbSNP
rs370119189 1505 dbSNP
rs1038895155 1515 dbSNP
rs1407782151 1517 dbSNP
rs1386640607 1522 dbSNP
rs941414320 1523 dbSNP
rs1332966833 1526 dbSNP
rs761362069 1529 dbSNP
rs889785780 1531 dbSNP
rs1279221291 1542 dbSNP
rs1327278765 1551 dbSNP
rs776381463 1552 dbSNP
rs1226357134 1553 dbSNP
rs1269711615 1555 dbSNP
rs1329595291 1558 dbSNP
rs768255655 1562 dbSNP
rs1173679458 1570 dbSNP
rs1413344930 1573 dbSNP
rs183342348 1579 dbSNP
rs931913698 1580 dbSNP
rs550300668 1581 dbSNP
rs1250648588 1597 dbSNP
rs530252410 1598 dbSNP
rs1028081346 1599 dbSNP
rs1247234775 1602 dbSNP
rs368791817 1607 dbSNP
rs41308326 1623 dbSNP
rs998063756 1625 dbSNP
rs957071466 1626 dbSNP
rs1406049212 1635 dbSNP
rs1461959807 1640 dbSNP
rs965240218 1655 dbSNP
rs1201865900 1664 dbSNP
rs926957893 1667 dbSNP
rs1273802050 1668 dbSNP
rs1336175696 1676 dbSNP
rs1018911652 1680 dbSNP
rs1005277947 1686 dbSNP
rs746536435 1689 dbSNP
rs1263648116 1691 dbSNP
rs1358325960 1693 dbSNP
rs1216871727 1696 dbSNP
rs1209930584 1704 dbSNP
rs1337992375 1706 dbSNP
rs971030865 1712 dbSNP
rs1453788931 1716 dbSNP
rs1481785144 1719 dbSNP
rs1049608630 1722 dbSNP
rs1384555006 1728 dbSNP
rs567582649 1738 dbSNP
rs1446822386 1741 dbSNP
rs1025014987 1751 dbSNP
rs774957384 1753 dbSNP
rs76826100 1763 dbSNP
rs17449017 1768 dbSNP
rs895323967 1775 dbSNP
rs752911944 1781 dbSNP
rs1370717035 1783 dbSNP
rs961851561 1787 dbSNP
rs749608192 1788 dbSNP
rs1171872936 1790 dbSNP
rs1431678800 1793 dbSNP
rs1308903749 1796 dbSNP
rs1401723734 1797 dbSNP
rs1017062075 1804 dbSNP
rs528003903 1809 dbSNP
rs1168190909 1815 dbSNP
rs1246709085 1822 dbSNP
rs777986191 1836 dbSNP
rs1339515844 1839 dbSNP
rs1206642996 1840 dbSNP
rs928188711 1841 dbSNP
rs1042079397 1847 dbSNP
rs945035952 1849 dbSNP
rs1482691611 1852 dbSNP
rs756567895 1855 dbSNP
rs1258779163 1858 dbSNP
rs989646142 1873 dbSNP
rs998164635 1883 dbSNP
rs901171776 1884 dbSNP
rs1451440473 1888 dbSNP
rs748287557 1894 dbSNP
rs1377302204 1895 dbSNP
rs1464676365 1897 dbSNP
rs1304808476 1898 dbSNP
rs945954317 1899 dbSNP
rs558918004 1903 dbSNP
rs190587574 1905 dbSNP
rs1362896154 1906 dbSNP
rs1229991623 1908 dbSNP
rs1295592152 1909 dbSNP
rs1311098639 1914 dbSNP
rs17449010 1915 dbSNP
rs935805241 1920 dbSNP
rs532195543 1925 dbSNP
rs1483031305 1927 dbSNP
rs927052023 1930 dbSNP
rs1206655471 1934 dbSNP
rs7786554 1946 dbSNP
rs543577665 1947 dbSNP
rs1246754943 1948 dbSNP
rs1466595959 1949 dbSNP
rs965292801 1964 dbSNP
rs1274470345 1984 dbSNP
rs1015445878 1989 dbSNP
rs1424192207 1991 dbSNP
rs1189304950 2000 dbSNP
rs1266850998 2004 dbSNP
rs886062254 2006 dbSNP
rs1431499488 2016 dbSNP
rs1004923725 2018 dbSNP
rs1178568018 2024 dbSNP
rs1378394785 2026 dbSNP
rs1470154772 2027 dbSNP
rs950767708 2029 dbSNP
rs1247194856 2042 dbSNP
rs1386363597 2044 dbSNP
rs1027622578 2047 dbSNP
rs1289361120 2060 dbSNP
rs1362115659 2063 dbSNP
rs1384531909 2078 dbSNP
rs1302992439 2080 dbSNP
rs148827747 2084 dbSNP
rs1227430891 2097 dbSNP
rs1266556438 2099 dbSNP
rs973397854 2105 dbSNP
rs995332736 2110 dbSNP
rs755003157 2120 dbSNP
rs1439307588 2126 dbSNP
rs1487569722 2132 dbSNP
rs1192954063 2136 dbSNP
rs1269899360 2143 dbSNP
rs1033876452 2147 dbSNP
rs1180280087 2153 dbSNP
rs1303746523 2160 dbSNP
rs186111902 2164 dbSNP
rs1426468287 2170 dbSNP
rs541311768 2180 dbSNP
rs1003696041 2188 dbSNP
rs114796827 2201 dbSNP
rs1159790633 2203 dbSNP
rs207467747 2210 dbSNP
rs1043027231 2215 dbSNP
rs1455951564 2216 dbSNP
rs1294713324 2217 dbSNP
rs1028403560 2223 dbSNP
rs1408916283 2225 dbSNP
rs1286060019 2232 dbSNP
rs945616152 2238 dbSNP
rs1224654431 2242 dbSNP
rs558870068 2243 dbSNP
rs1320395089 2248 dbSNP
rs757392498 2248 dbSNP
rs1292677980 2252 dbSNP
rs1482761786 2259 dbSNP
rs1179036329 2260 dbSNP
rs538658902 2261 dbSNP
rs998218675 2268 dbSNP
rs1053435192 2269 dbSNP
rs1177517284 2282 dbSNP
rs569968863 2293 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agacccgagacugccAACCGu 5'
                         ||||| 
Target 5' ---------------UUGGCa 3'
 		1 - 6
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000355633.5 | 3UTR | UUGGCACAUUUCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-5189-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT159806 PPP3R1 protein phosphatase 3 regulatory subunit B, alpha 2 4
MIRT441371 KIAA0513 KIAA0513 2 4
MIRT441381 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT441403 FAM9C family with sequence similarity 9 member C 2 2
MIRT441434 KMT2A lysine methyltransferase 2A 2 2
MIRT441539 CHD7 chromodomain helicase DNA binding protein 7 2 2
MIRT441706 RP1L1 RP1 like 1 2 2
MIRT441853 KCNJ10 potassium voltage-gated channel subfamily J member 10 2 2
MIRT441964 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT442090 ZNRF2 zinc and ring finger 2 2 2
MIRT442162 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442194 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442334 WNT9B Wnt family member 9B 2 2
MIRT442481 SLC10A7 solute carrier family 10 member 7 2 2
MIRT442665 PNN pinin, desmosome associated protein 2 2
MIRT442976 PHACTR2 phosphatase and actin regulator 2 2 2
MIRT443044 HPS4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 2 2
MIRT443112 VLDLR very low density lipoprotein receptor 2 2
MIRT443138 MTMR6 myotubularin related protein 6 2 2
MIRT443180 DENND4C DENN domain containing 4C 2 2
MIRT443271 TSPAN15 tetraspanin 15 2 2
MIRT443355 XPR1 xenotropic and polytropic retrovirus receptor 1 2 2
MIRT443371 PLXNA2 plexin A2 2 2
MIRT443380 CHML CHM like, Rab escort protein 2 2 2
MIRT443415 HOXA1 homeobox A1 2 2
MIRT443666 FLT1 fms related tyrosine kinase 1 2 2
MIRT443720 TAF1B TATA-box binding protein associated factor, RNA polymerase I subunit B 2 2
MIRT443727 USP14 ubiquitin specific peptidase 14 2 2
MIRT443798 SREBF2 sterol regulatory element binding transcription factor 2 2 2
MIRT472529 NACC1 nucleus accumbens associated 1 2 4
MIRT479151 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT479280 CHD4 chromodomain helicase DNA binding protein 4 2 6
MIRT485414 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 4
MIRT491210 MLLT1 MLLT1, super elongation complex subunit 2 4
MIRT494879 CERS4 ceramide synthase 4 2 2
MIRT494917 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT495018 C2CD4B C2 calcium dependent domain containing 4B 2 2
MIRT495030 FAM179A TOG array regulator of axonemal microtubules 2 2 4
MIRT495301 CHST12 carbohydrate sulfotransferase 12 2 2
MIRT495406 SPPL3 signal peptide peptidase like 3 2 2
MIRT496156 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT496643 MFAP3 microfibril associated protein 3 2 2
MIRT496654 PITPNM3 PITPNM family member 3 2 2
MIRT496707 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT496907 TRIM56 tripartite motif containing 56 2 2
MIRT496918 GUSB glucuronidase beta 2 2
MIRT497451 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498336 PRELID2 PRELI domain containing 2 2 2
MIRT498367 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT498382 GPRC5B G protein-coupled receptor class C group 5 member B 2 2
MIRT498396 KIF6 kinesin family member 6 2 2
MIRT499062 CTBP1 C-terminal binding protein 1 2 4
MIRT525235 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 2
MIRT528266 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT528320 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT533128 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 2
MIRT535654 NLN neurolysin 2 4
MIRT535691 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT574157 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT574560 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT576580 Ptbp1 polypyrimidine tract binding protein 1 2 2
MIRT618622 GREB1 growth regulation by estrogen in breast cancer 1 2 4
MIRT619234 FBXL4 F-box and leucine rich repeat protein 4 2 2
MIRT621894 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT624458 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT630109 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT640034 NRXN3 neurexin 3 2 2
MIRT642824 SOD2 superoxide dismutase 2 2 2
MIRT645010 NGRN neugrin, neurite outgrowth associated 2 2
MIRT646486 APBB3 amyloid beta precursor protein binding family B member 3 2 2
MIRT648793 VPS8 VPS8, CORVET complex subunit 2 2
MIRT649091 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT649956 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT653049 STON2 stonin 2 2 2
MIRT657770 GLRX2 glutaredoxin 2 2 2
MIRT658177 FBXO9 F-box protein 9 2 2
MIRT662988 TMEM59 transmembrane protein 59 2 2
MIRT663438 FBXO2 F-box protein 2 2 2
MIRT669209 CBX8 chromobox 8 2 2
MIRT687227 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT690849 PVR poliovirus receptor 2 2
MIRT692246 POLR3F RNA polymerase III subunit F 2 2
MIRT700688 POLR3D RNA polymerase III subunit D 2 2
MIRT704848 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT710305 NUDT16 nudix hydrolase 16 2 2
MIRT712826 TIGIT T-cell immunoreceptor with Ig and ITIM domains 2 2
MIRT714001 SLC2A11 solute carrier family 2 member 11 2 2
MIRT715671 HEBP2 heme binding protein 2 2 2
MIRT718025 SSX2IP SSX family member 2 interacting protein 2 2
MIRT720733 ELOVL7 ELOVL fatty acid elongase 7 2 2
MIRT723280 KRTAP21-2 keratin associated protein 21-2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5189-3p Osimertinib 71496458 NSC779217 approved resistant Low Non-Small Cell Lung Cancer tissue
hsa-miR-5189-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-5189-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-5189-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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