miRTarBase - #MIRT443445


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pre-miRNA Information
pre-miRNA hsa-mir-3123   
Genomic Coordinates chr1: 241132272 - 241132346
Description Homo sapiens miR-3123 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3123
Sequence 49| CAGAGAAUUGUUUAAUC |65
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 1 + 241132323 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1453759221 1 dbSNP
rs968575171 5 dbSNP
rs979407933 9 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SERPINB4   
Synonyms LEUPIN, PI11, SCCA-2, SCCA1, SCCA2
Description serpin family B member 4
Transcript NM_002974   
Expression
Putative miRNA Targets on SERPINB4
3'UTR of SERPINB4
(miRNA target sites are highlighted)		 
>SERPINB4|NM_002974|3'UTR
   1 ATGCAATTAGTCTGTCACTCCATTTAGAAAATGTTCACCTAGAGGTGTTCTGGTAAACTGATTGCTGGCAACAACAGATT
  81 CTCTTGGCTCATATTTCTTTTCTATCTCATCTTGATGATGATAGTCATCATCAAGAATTTAATGATTAAAATAGCATGCC
 161 TTTCTCTCTTTCTCTTAATAAGCCCACATATAAATGTACTTTTCCTTCCAGAAAAATTTCCCTTGAGGAAAAATGTCCAA
 241 GATAAGATGAATCATTTAATACCGTGTCTTCTAAATTTGAAATATAATTCTGTTTCTGACCTGTTTTAAATGAACCAAAC
 321 CAAATCATACTTTCTCTTCAAATTTAGCAACCTAGAAACACACATTTCTTTGAATTTAGGTGATACCTAAATCCTTCTTA
 401 TGTTTCTAAATTTTGTGATTCTATAAAACACATCATCAATAAAATAATGACATAAAATCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuaauUUGU-UAAGAGAc 5'
               |||| ||||||| 
Target 5' gcaacAACAGATTCTCTt 3'
 68 - 85 152.00 -7.60
2 
miRNA  3' cuaauuuguuAAGAGAc 5'
                    |||||| 
Target 5' tagcatgcctTTCTCTc 3'
 152 - 168 120.00 -5.40
3 
miRNA  3' cuaaUUUGUUAAGAGAc 5'
              | ||| ||||:| 
Target 5' aaacACACATTTCTTTg 3'
 356 - 372 109.00 -7.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31572538 9 COSMIC
COSN31592314 12 COSMIC
COSN30456313 20 COSMIC
COSN31570996 20 COSMIC
COSN30474116 21 COSMIC
COSN13772575 22 COSMIC
COSN30163174 26 COSMIC
COSN30189688 27 COSMIC
COSN2461636 58 COSMIC
COSN9340549 59 COSMIC
COSN30448394 77 COSMIC
COSN2533850 81 COSMIC
COSN31525334 81 COSMIC
COSN7365569 82 COSMIC
COSN30156541 85 COSMIC
COSN30526660 87 COSMIC
COSN30117164 97 COSMIC
COSN30454180 97 COSMIC
COSN30163167 104 COSMIC
COSN31609081 106 COSMIC
COSN31518039 107 COSMIC
COSN30523690 108 COSMIC
COSN31605327 111 COSMIC
COSN30525327 119 COSMIC
COSN30452766 120 COSMIC
COSN28863931 123 COSMIC
COSN31492290 165 COSMIC
COSN28190138 204 COSMIC
COSN2493908 241 COSMIC
COSN15804736 330 COSMIC
COSN32063450 382 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766892133 2 dbSNP
rs761096806 4 dbSNP
rs774203099 7 dbSNP
rs1330799578 9 dbSNP
rs1015865610 10 dbSNP
rs768419150 16 dbSNP
rs1390428774 17 dbSNP
rs1201192612 18 dbSNP
rs1401850197 20 dbSNP
rs1281001703 23 dbSNP
rs748903916 26 dbSNP
rs1370366339 29 dbSNP
rs1298084294 33 dbSNP
rs149839364 34 dbSNP
rs1427675398 38 dbSNP
rs769294961 39 dbSNP
rs745820992 41 dbSNP
rs757104006 42 dbSNP
rs1004044939 44 dbSNP
rs746805262 45 dbSNP
rs1172500052 47 dbSNP
rs777478386 49 dbSNP
rs1375711059 51 dbSNP
rs1277699818 53 dbSNP
rs1477584471 55 dbSNP
rs1198661039 56 dbSNP
rs1341461255 62 dbSNP
rs886559425 65 dbSNP
rs755859004 66 dbSNP
rs1363242947 68 dbSNP
rs1402380482 74 dbSNP
rs1317457792 91 dbSNP
rs994844431 95 dbSNP
rs187260193 97 dbSNP
rs1038982507 104 dbSNP
rs944989465 106 dbSNP
rs183382611 107 dbSNP
rs754170994 112 dbSNP
rs544301747 115 dbSNP
rs1356022724 120 dbSNP
rs1332672384 122 dbSNP
rs576236932 123 dbSNP
rs1371718165 131 dbSNP
rs1248294774 133 dbSNP
rs1437404352 141 dbSNP
rs1157735160 142 dbSNP
rs1380314274 159 dbSNP
rs556190816 162 dbSNP
rs1161935080 167 dbSNP
rs945572104 169 dbSNP
rs915355389 175 dbSNP
rs756336234 179 dbSNP
rs1325903138 180 dbSNP
rs1168621352 183 dbSNP
rs1334423311 186 dbSNP
rs1446312262 189 dbSNP
rs1310284470 194 dbSNP
rs989247827 198 dbSNP
rs959081434 203 dbSNP
rs539759645 204 dbSNP
rs1456286108 221 dbSNP
rs780825370 231 dbSNP
rs576622613 235 dbSNP
rs754839899 236 dbSNP
rs751446019 241 dbSNP
rs1458860655 243 dbSNP
rs1165570672 247 dbSNP
rs1185163630 248 dbSNP
rs553587207 249 dbSNP
rs1465440924 253 dbSNP
rs1439427372 255 dbSNP
rs1379423901 260 dbSNP
rs1275302365 263 dbSNP
rs533610572 264 dbSNP
rs567840006 266 dbSNP
rs1245349303 270 dbSNP
rs1204463297 283 dbSNP
rs1340114060 289 dbSNP
rs1015501851 290 dbSNP
rs374617980 296 dbSNP
rs1458791286 298 dbSNP
rs1198436819 299 dbSNP
rs1254851419 300 dbSNP
rs1423906318 303 dbSNP
rs1190145948 314 dbSNP
rs190875921 315 dbSNP
rs576574009 316 dbSNP
rs952580199 317 dbSNP
rs1402958666 320 dbSNP
rs1464729459 324 dbSNP
rs1027211919 325 dbSNP
rs994895067 334 dbSNP
rs1397890585 335 dbSNP
rs1314594447 337 dbSNP
rs900582376 339 dbSNP
rs690543 340 dbSNP
rs1200581841 343 dbSNP
rs1378734357 343 dbSNP
rs1008852346 346 dbSNP
rs1230544717 351 dbSNP
rs1255058816 355 dbSNP
rs1282718988 360 dbSNP
rs1483269457 366 dbSNP
rs1444853077 372 dbSNP
rs1260477797 373 dbSNP
rs1488232588 375 dbSNP
rs890417833 380 dbSNP
rs568875375 386 dbSNP
rs1175577775 394 dbSNP
rs1378449328 401 dbSNP
rs1467818430 417 dbSNP
rs1307930516 419 dbSNP
rs186796712 423 dbSNP
rs915425413 437 dbSNP
rs367995950 445 dbSNP
rs1053943132 447 dbSNP
rs1298744963 448 dbSNP
rs937765713 457 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000341074.5 | 3UTR | UUGGCUCAUAUUUCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
113 hsa-miR-3123 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT058369 TBCEL tubulin folding cofactor E like 2 4
MIRT059816 EFNA1 ephrin A1 2 2
MIRT066850 TMEM19 transmembrane protein 19 2 2
MIRT071503 CALM1 calmodulin 1 2 6
MIRT073758 NUBP1 nucleotide binding protein 1 2 2
MIRT074324 TNRC6A trinucleotide repeat containing 6A 2 10
MIRT094805 LMNB1 lamin B1 2 2
MIRT099173 MAP3K4 mitogen-activated protein kinase kinase kinase 4 2 2
MIRT099545 ID4 inhibitor of DNA binding 4, HLH protein 2 2
MIRT122643 E2F3 E2F transcription factor 3 2 2
MIRT180918 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 8
MIRT192844 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT224984 BAG4 BCL2 associated athanogene 4 2 2
MIRT246065 NRAS NRAS proto-oncogene, GTPase 2 2
MIRT357085 PRRC1 proline rich coiled-coil 1 2 2
MIRT378170 C5ORF51 chromosome 5 open reading frame 51 2 2
MIRT441636 KDM5A lysine demethylase 5A 2 2
MIRT441802 BCAS1 breast carcinoma amplified sequence 1 2 2
MIRT443019 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT443445 SERPINB4 serpin family B member 4 2 2
MIRT443661 SERPINB3 serpin family B member 3 2 2
MIRT443776 STS steroid sulfatase 2 2
MIRT444663 TSPAN14 tetraspanin 14 2 2
MIRT444924 KIAA1522 KIAA1522 2 2
MIRT445378 FOXO1 forkhead box O1 2 2
MIRT447920 PAIP2B poly(A) binding protein interacting protein 2B 2 2
MIRT449202 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT449713 TSPYL1 TSPY like 1 2 2
MIRT450403 TMEM47 transmembrane protein 47 2 2
MIRT450787 PAPOLG poly(A) polymerase gamma 2 2
MIRT451381 C19orf43 telomerase RNA component interacting RNase 2 2
MIRT452507 WDR1 WD repeat domain 1 2 2
MIRT453264 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT454642 FAM83H family with sequence similarity 83 member H 2 2
MIRT455513 C6orf106 chromosome 6 open reading frame 106 2 2
MIRT456709 LDB1 LIM domain binding 1 2 2
MIRT457231 AP3D1 adaptor related protein complex 3 delta 1 subunit 2 2
MIRT459235 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT460553 IFNAR1 interferon alpha and beta receptor subunit 1 2 4
MIRT461424 CTSL2 cathepsin V 2 3
MIRT462869 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT467178 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT469233 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT474125 LIPC lipase C, hepatic type 2 2
MIRT475509 HSP90B1 heat shock protein 90 beta family member 1 2 4
MIRT478134 DHX36 DEAH-box helicase 36 2 2
MIRT481326 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2 2
MIRT482003 AMOTL2 angiomotin like 2 2 2
MIRT482230 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT483436 RHOXF2B Rhox homeobox family member 2B 2 2
MIRT483824 ZC3H12B zinc finger CCCH-type containing 12B 2 2
MIRT492051 TNFSF9 TNF superfamily member 9 2 2
MIRT494114 DLX6 distal-less homeobox 6 2 2
MIRT498882 ZNF12 zinc finger protein 12 2 10
MIRT499674 NPHP3 nephrocystin 3 2 2
MIRT506932 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT509461 ZNF587 zinc finger protein 587 2 6
MIRT510048 AKR1B10 aldo-keto reductase family 1 member B10 2 4
MIRT514807 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT515217 CRCP CGRP receptor component 2 2
MIRT515486 INCENP inner centromere protein 2 4
MIRT517765 ZNF366 zinc finger protein 366 2 4
MIRT518216 TRMT10B tRNA methyltransferase 10B 2 2
MIRT519602 ZNF805 zinc finger protein 805 2 2
MIRT523570 GGCX gamma-glutamyl carboxylase 2 4
MIRT525795 SOD2 superoxide dismutase 2 2 2
MIRT533055 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT534218 SLC37A3 solute carrier family 37 member 3 2 4
MIRT535633 NR2E1 nuclear receptor subfamily 2 group E member 1 2 2
MIRT535863 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT536344 LEFTY1 left-right determination factor 1 2 2
MIRT537923 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT543114 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT544717 ZNF529 zinc finger protein 529 2 2
MIRT544847 BASP1 brain abundant membrane attached signal protein 1 2 4
MIRT545536 ARF3 ADP ribosylation factor 3 2 2
MIRT547124 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT548070 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548446 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT548626 DAZAP1 DAZ associated protein 1 2 4
MIRT550259 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT551940 AKAP8 A-kinase anchoring protein 8 2 4
MIRT552511 ZIK1 zinc finger protein interacting with K protein 1 2 4
MIRT554015 SPIRE1 spire type actin nucleation factor 1 2 2
MIRT556647 KPNA2 karyopherin subunit alpha 2 2 4
MIRT559744 ACOX1 acyl-CoA oxidase 1 2 2
MIRT560393 TMEM254 transmembrane protein 254 2 2
MIRT562234 HMGB2 high mobility group box 2 2 2
MIRT563325 ORC4 origin recognition complex subunit 4 2 2
MIRT563697 RPS26 ribosomal protein S26 2 2
MIRT565066 USP25 ubiquitin specific peptidase 25 2 2
MIRT565349 TMED2 transmembrane p24 trafficking protein 2 2 2
MIRT565624 SLC31A1 solute carrier family 31 member 1 2 2
MIRT566379 PNISR PNN interacting serine and arginine rich protein 2 2
MIRT567575 FEM1C fem-1 homolog C 2 2
MIRT569383 DDX20 DEAD-box helicase 20 2 2
MIRT570037 FAM228A family with sequence similarity 228 member A 2 2
MIRT573269 DCAF10 DDB1 and CUL4 associated factor 10 2 2
MIRT573912 PARP1 poly(ADP-ribose) polymerase 1 2 2
MIRT620034 ST6GALNAC3 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 2 2
MIRT635606 ZWILCH zwilch kinetochore protein 2 2
MIRT644413 FRMD6 FERM domain containing 6 2 2
MIRT652528 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT656238 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT661373 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT662530 PNPLA4 patatin like phospholipase domain containing 4 2 2
MIRT675551 MALL mal, T-cell differentiation protein like 2 2
MIRT693650 ACBD7 acyl-CoA binding domain containing 7 2 2
MIRT696348 SLC35D2 solute carrier family 35 member D2 2 2
MIRT705815 AKNA AT-hook transcription factor 2 2
MIRT707632 TARDBP TAR DNA binding protein 2 2
MIRT717902 COPS8 COP9 signalosome subunit 8 2 2
MIRT723626 SOBP sine oculis binding protein homolog 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3123 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-3123 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-3123 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-3123 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3123 Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)

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