miRTarBase - #MIRT443472


—
pre-miRNA Information
pre-miRNA hsa-mir-637   
Genomic Coordinates chr19: 3961414 - 3961512
Synonyms MIRN637, hsa-mir-637, MIR637
Description Homo sapiens miR-637 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-637
Sequence 61| ACUGGGGGCUUUCGGGCUCUGCGU |84
Evidence Experimental
Experiments SAGE
Expression Profile
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN518997 2 COSMIC
COSN1082357 6 COSMIC
COSN13804010 13 COSMIC
COSN1082358 14 COSMIC
COSN30450169 14 COSMIC
COSN30532059 15 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1416171403 2 dbSNP
rs200224173 4 dbSNP
rs1475121792 9 dbSNP
rs202144891 13 dbSNP
rs767027646 14 dbSNP
rs529226642 16 dbSNP
rs751534327 17 dbSNP
rs758718359 17 dbSNP
rs149472696 20 dbSNP
rs773105166 21 dbSNP
rs543903246 22 dbSNP
rs374248027 24 dbSNP
Putative Targets

Gene Information
Gene Symbol ACPP   
Synonyms 5'-NT, ACP-3, ACP3
Description acid phosphatase, prostate
Transcript NM_001099   
Other Transcripts NM_001134194   
Expression
Putative miRNA Targets on ACPP
3'UTR of ACPP
(miRNA target sites are highlighted)		 
>ACPP|NM_001099|3'UTR
   1 TGTGCACAGAGATCTCTGTAGAAGGAGTAGCTGCCCTTTCTCAGGGCAGATGATGCTTTGAGAACATACTTTGGCCATTA
  81 CCCCCAGCTTTGAGGAAAATGGGCTTTGGATGATTATTTTATGTTTTAGGGACCCCCAACCTCAGGCAATTCCTACCTCT
 161 TCACCTGACCCTGCCCCCACTTGCCATAAAACTTAGCTAAGTTTTGTTTTGTTTTTCAGCGTTAATGTAAAGGGGCAGCA
 241 GTGCCAAAATATAATCAGAGATAAAGCTTAGGTCAAAGTTCATAGAGTTCCCATGAACTATATGACTGGCCACACAGGAT
 321 CTTTTGTATTTAAGGATTCTGAGATTTTGCTTGAGCAGGATTAGATAAGGCTGTTCTTTAAATGTCTGAAATGGAACAGA
 401 TTTCAAAAAAAAACCCCACAATCTAGGATGGGAACAAGGAAGGAAAGATGTGAATAGGCTGATGGGCAAAAAACCAATTT
 481 ACCCATCAGTTCCAGCCTTCTCTCAAGGAGAGGCAAAGAAAGGAGATACAGTGGAGACATCTGGAAAGTTTTCTCCACTG
 561 GAAAACTGCTACTATCTGTTTTTATATTTCTGTTAAAATATATGAGGCTACAGAACTAAAAATTAAAACCTCTTTGTGTC
 641 CCTTGGTCCTGGAACATTTATGTTCCTTTTAAAGAAACAAAAATCAAACTTTACAGAAAGATTTGATGTATGTAATACAT
 721 ATAGCAGCTCTTGAAGTATATATATCATAGCAAATAAGTCATCTGATGAGAACAAGCTATTTGGGCACAACACATCAGGA
 801 AAGAGAGCACCACGTGATGGAGTTTCTCTAGAAGCTCCAGTGATAAGAGATGTTGACTCTAAAGTTGATTTAAGGCCAGG
 881 CATGGTGGTTTACGCCTATAATCCCAGCATTTTGGGAGTCCGAGGTGGGCAGATCACTTGAGCTCAGGAGGTCAAGATCA
 961 GCCTGGGCAACATGGTGAAACCTGGTCTCTACATAAAATACAAAAACTTAGATGGGCATGGTGGTGTGTGCCTATAGTCC
1041 CACTACTTGTGGGGCTAAGGCAGGAGGATCACTTGAGCCCCGGAGGTCGAGGCTACAGTGAGCCAAGAGTGCACTACTGT
1121 ACTCCAGCCAGGGCAAGAGAGCGAGACCCTGTCTCAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAAATAA
1201 AAACAAAGTTGATTAAGAAAGGAAGTATAGGCCAGGCACAGTGGCTCACACCTGTAATCCTTGCATTTTGGAAGGCTGAG
1281 GCAGGAGGATCACTTTAGGCCTGGTGTGTTCAAGACCAGCCTGGTCAACATAGTGAGACACTGTCTCTACCAAAAAAAGG
1361 AAGGAAGGGACACATATCAAACTGAAACAAAATTAGAAATGTAATTATGTTCTAAGTGCCTCCAAGTTCAAAACTTATTG
1441 GAATGTTGAGAGTGTGGTTACGAAATACGTTAGGAGGACAAAAGGAATGTGTAAGTCTTTAATGCCGATATCTTCAGAAA
1521 ACCTAAGCAAACTTACAGGTCCTGCTGAAACTGCCCACTCTGCAAGAAGAAATCATGATATAGCTTTGCCATGTGGCAGA
1601 TCTACATGTCTAGAGAACACTGTGCTCTATTACCATTATGGATAAAGATGAGATGGTTTCTAGAGATGGTTTCTACTGGC
1681 TGCCAGAATCTAGAGCAAAGCCATCCCCGCTCCTGGTTGGTCACAGAATGACTGACAAAGACATCGATTGATATGCTTCT
1761 TTGTGTTATTTCCCTCCCAAGTAAATGTTTGTCCTTGGGTCCATTTTCTATGCTTGTAACTGTCTTCTAGCAGTGAGCCA
1841 AATGTAAAATAGTGAATAAAGTCATTATTAGGAAGTTCAAAAGCATTGCTTTTATAATGAACTTAGAAAAACGTATGTGT
1921 GTGTGTTTAATTAGAATAAAATTCCTCTAGGCAGATTTCAGGAGCTCCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugcgucUCGGGCUUUCGGGGGUCa 5'
                :|||  |   ||||||| 
Target 5' tactttGGCC--ATTACCCCCAGc 3'
 67 - 88 142.00 -17.90
2 
miRNA  3' ugcGUCUCGGGCUUUCGGGGGUca 5'
             | || ||:    |||||||  
Target 5' cacCTGACCCT----GCCCCCAct 3'
 162 - 181 131.00 -19.70
3 
miRNA  3' ugcgucuCGGGCUUUC-GGGGGUca 5'
                 |::: |::| ||||||  
Target 5' attttatGTTTTAGGGACCCCCAac 3'
 116 - 140 129.00 -12.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26727670 25 COSMIC
COSN30484846 26 COSMIC
COSN30524761 27 COSMIC
COSN30453355 37 COSMIC
COSN30167242 45 COSMIC
COSN30176465 75 COSMIC
COSN30510688 88 COSMIC
COSN27647049 140 COSMIC
COSN31528339 158 COSMIC
COSN30167250 201 COSMIC
COSN20896693 221 COSMIC
COSN7818010 245 COSMIC
COSN31565276 405 COSMIC
COSN14589775 415 COSMIC
COSN14814491 454 COSMIC
COSN18298974 511 COSMIC
COSN16205045 1031 COSMIC
COSN26043309 1204 COSMIC
COSN4997832 1207 COSMIC
COSN1267721 1264 COSMIC
COSN20069111 1359 COSMIC
COSN9237427 1404 COSMIC
COSN32079625 1472 COSMIC
COSN24407481 1683 COSMIC
COSN29313020 1761 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs150662127 2 dbSNP
rs752360156 6 dbSNP
rs1431518620 7 dbSNP
rs757989402 8 dbSNP
rs1484513730 10 dbSNP
rs1184659703 11 dbSNP
rs7625966 22 dbSNP
rs1042330 25 dbSNP
rs1190692284 30 dbSNP
rs1169613563 31 dbSNP
rs1420344787 32 dbSNP
rs756608663 35 dbSNP
rs1174003267 37 dbSNP
rs73215937 38 dbSNP
rs547310027 48 dbSNP
rs754061450 51 dbSNP
rs1186629252 55 dbSNP
rs562221924 66 dbSNP
rs1242249524 73 dbSNP
rs919953708 78 dbSNP
rs1307050245 91 dbSNP
rs931284152 93 dbSNP
rs1049026131 94 dbSNP
rs886328247 110 dbSNP
rs529510064 112 dbSNP
rs1050273091 113 dbSNP
rs1462994081 121 dbSNP
rs1264153922 123 dbSNP
rs779314422 132 dbSNP
rs140893577 138 dbSNP
rs1482078689 171 dbSNP
rs1260206040 175 dbSNP
rs1000144114 176 dbSNP
rs144839895 177 dbSNP
rs1282430276 178 dbSNP
rs756958439 184 dbSNP
rs1450134219 187 dbSNP
rs1383365796 189 dbSNP
rs1330456380 203 dbSNP
rs1242953586 207 dbSNP
rs892028795 211 dbSNP
rs1458569333 212 dbSNP
rs1181028886 220 dbSNP
rs1001324523 221 dbSNP
rs1804138 222 dbSNP
rs758606177 224 dbSNP
rs1024448640 227 dbSNP
rs1418575326 231 dbSNP
rs1176960182 235 dbSNP
rs1379534128 244 dbSNP
rs780219198 254 dbSNP
rs1464757532 261 dbSNP
rs1178451550 265 dbSNP
rs1244245783 265 dbSNP
rs1011171426 283 dbSNP
rs1020504091 301 dbSNP
rs1205485789 307 dbSNP
rs1335777184 308 dbSNP
rs971992856 311 dbSNP
rs967618406 314 dbSNP
rs746959450 319 dbSNP
rs1360113495 326 dbSNP
rs750271426 331 dbSNP
rs979839283 337 dbSNP
rs551484240 339 dbSNP
rs372784570 346 dbSNP
rs557576163 367 dbSNP
rs1376141923 369 dbSNP
rs1042332 371 dbSNP
rs1298466231 373 dbSNP
rs951811819 374 dbSNP
rs964548257 378 dbSNP
rs1042333 385 dbSNP
rs189681210 389 dbSNP
rs940587315 394 dbSNP
rs1158563092 398 dbSNP
rs919984804 398 dbSNP
rs779847996 400 dbSNP
rs1232105454 401 dbSNP
rs1438305415 405 dbSNP
rs759194452 405 dbSNP
rs1178080513 414 dbSNP
rs181128421 414 dbSNP
rs1042334 415 dbSNP
rs1224871816 421 dbSNP
rs564956128 422 dbSNP
rs1490529781 424 dbSNP
rs907794942 427 dbSNP
rs309995 429 dbSNP
rs1237874345 437 dbSNP
rs147525822 440 dbSNP
rs1307463600 444 dbSNP
rs1218382593 447 dbSNP
rs1480601862 448 dbSNP
rs907062872 453 dbSNP
rs889849966 457 dbSNP
rs2239698 475 dbSNP
rs1431557693 476 dbSNP
rs1054378135 512 dbSNP
rs555974908 513 dbSNP
rs1359348506 540 dbSNP
rs186013868 543 dbSNP
rs1295740784 544 dbSNP
rs1804127 548 dbSNP
rs1418427860 558 dbSNP
rs1160328171 568 dbSNP
rs769611339 573 dbSNP
rs1432936744 576 dbSNP
rs1423388076 585 dbSNP
rs140195846 587 dbSNP
rs772909078 608 dbSNP
rs1480847241 613 dbSNP
rs1262585683 632 dbSNP
rs1424688046 646 dbSNP
rs1466979126 657 dbSNP
rs1486822892 666 dbSNP
rs1393324073 679 dbSNP
rs1261203557 681 dbSNP
rs1168288710 693 dbSNP
rs1209219877 695 dbSNP
rs1310207194 697 dbSNP
rs1011201158 698 dbSNP
rs891805280 703 dbSNP
rs1223757248 705 dbSNP
rs1339385390 707 dbSNP
rs559882805 709 dbSNP
rs1275787063 713 dbSNP
rs1383377752 717 dbSNP
rs1353787509 718 dbSNP
rs1458376097 726 dbSNP
rs1387829643 729 dbSNP
rs762588641 731 dbSNP
rs1289945170 742 dbSNP
rs1465911229 743 dbSNP
rs1010447636 744 dbSNP
rs1019949763 748 dbSNP
rs1178953541 749 dbSNP
rs1024995294 750 dbSNP
rs1423134203 755 dbSNP
rs907338091 765 dbSNP
rs902842089 777 dbSNP
rs1294725157 778 dbSNP
rs534475776 781 dbSNP
rs1008510092 784 dbSNP
rs1262410596 786 dbSNP
rs1020267871 787 dbSNP
rs1482197652 798 dbSNP
rs572015722 806 dbSNP
rs1204008379 808 dbSNP
rs1364850496 812 dbSNP
rs1385774134 814 dbSNP
rs765876801 815 dbSNP
rs1027079468 821 dbSNP
rs1311300832 822 dbSNP
rs14192 830 dbSNP
rs1220788636 831 dbSNP
rs1256569704 842 dbSNP
rs982861019 843 dbSNP
rs1339136302 846 dbSNP
rs1222916969 855 dbSNP
rs1804126 865 dbSNP
rs149980810 875 dbSNP
rs369547523 881 dbSNP
rs929252083 882 dbSNP
rs1463654709 883 dbSNP
rs542530466 886 dbSNP
rs1164146717 889 dbSNP
rs188916832 891 dbSNP
rs1487542277 894 dbSNP
rs928516546 895 dbSNP
rs1264097203 900 dbSNP
rs1478926980 901 dbSNP
rs1184019139 909 dbSNP
rs1457140025 913 dbSNP
rs1236046874 917 dbSNP
rs1126658 919 dbSNP
rs1197184386 922 dbSNP
rs11710175 923 dbSNP
rs1418555184 946 dbSNP
rs962033986 947 dbSNP
rs1126659 952 dbSNP
rs1357978764 968 dbSNP
rs533260678 982 dbSNP
rs892971926 983 dbSNP
rs1804136 985 dbSNP
rs1041437183 994 dbSNP
rs1327193959 1000 dbSNP
rs1393375582 1005 dbSNP
rs1348125247 1009 dbSNP
rs1397419850 1019 dbSNP
rs1423442783 1022 dbSNP
rs902873913 1024 dbSNP
rs1126660 1025 dbSNP
rs1041313407 1031 dbSNP
rs900048888 1035 dbSNP
rs925152526 1048 dbSNP
rs1378263565 1052 dbSNP
rs765680525 1053 dbSNP
rs1438075137 1061 dbSNP
rs1027194726 1068 dbSNP
rs952848275 1082 dbSNP
rs368290611 1083 dbSNP
rs1361657755 1086 dbSNP
rs1353544969 1087 dbSNP
rs1229315454 1090 dbSNP
rs1016074428 1094 dbSNP
rs946050231 1097 dbSNP
rs1323121462 1101 dbSNP
rs1045757530 1108 dbSNP
rs970769812 1112 dbSNP
rs1221756471 1114 dbSNP
rs982491080 1120 dbSNP
rs1489365867 1124 dbSNP
rs928575537 1138 dbSNP
rs1214699156 1143 dbSNP
rs958656988 1144 dbSNP
rs1340057274 1154 dbSNP
rs1470377071 1154 dbSNP
rs145212565 1155 dbSNP
rs1221918710 1156 dbSNP
rs1347562744 1156 dbSNP
rs370635160 1156 dbSNP
rs530394249 1156 dbSNP
rs537521424 1156 dbSNP
rs563006412 1156 dbSNP
rs755490700 1156 dbSNP
rs774292936 1156 dbSNP
rs777705181 1156 dbSNP
rs914435879 1156 dbSNP
rs758638758 1158 dbSNP
rs1411465456 1162 dbSNP
rs1443940211 1164 dbSNP
rs1320192016 1166 dbSNP
rs1343408803 1166 dbSNP
rs1158685820 1174 dbSNP
rs1401139590 1176 dbSNP
rs1381597909 1182 dbSNP
rs1417362008 1184 dbSNP
rs1317186921 1186 dbSNP
rs1359438151 1188 dbSNP
rs879608200 1190 dbSNP
rs758508644 1192 dbSNP
rs1381172610 1194 dbSNP
rs747147098 1195 dbSNP
rs947205145 1195 dbSNP
rs1245916964 1196 dbSNP
rs1470765920 1196 dbSNP
rs1055940465 1198 dbSNP
rs1192351076 1198 dbSNP
rs1310693036 1198 dbSNP
rs145366277 1199 dbSNP
rs9289427 1199 dbSNP
rs1406426477 1201 dbSNP
rs1454349005 1201 dbSNP
rs68002697 1201 dbSNP
rs202070207 1202 dbSNP
rs1169503595 1203 dbSNP
rs1005952770 1204 dbSNP
rs57884203 1204 dbSNP
rs1167935237 1205 dbSNP
rs1476043493 1209 dbSNP
rs1041467658 1210 dbSNP
rs780305977 1213 dbSNP
rs1283812212 1233 dbSNP
rs1126661 1234 dbSNP
rs943726194 1239 dbSNP
rs376736034 1248 dbSNP
rs1182178817 1250 dbSNP
rs1462922050 1251 dbSNP
rs1244045022 1264 dbSNP
rs1041069975 1275 dbSNP
rs1211898534 1276 dbSNP
rs961850420 1280 dbSNP
rs899495228 1283 dbSNP
rs1454433212 1286 dbSNP
rs1383257602 1287 dbSNP
rs1460739965 1288 dbSNP
rs1179141775 1290 dbSNP
rs1240019126 1291 dbSNP
rs755055574 1294 dbSNP
rs1355878186 1298 dbSNP
rs1328990541 1302 dbSNP
rs1404215407 1302 dbSNP
rs1030037614 1317 dbSNP
rs1446901358 1318 dbSNP
rs1157495280 1331 dbSNP
rs1425351708 1341 dbSNP
rs567207684 1348 dbSNP
rs997134028 1350 dbSNP
rs953410057 1351 dbSNP
rs1178625973 1352 dbSNP
rs986019135 1366 dbSNP
rs529581127 1367 dbSNP
rs1289592978 1368 dbSNP
rs772357078 1369 dbSNP
rs1248092311 1371 dbSNP
rs888638585 1372 dbSNP
rs1306055910 1378 dbSNP
rs1221825564 1384 dbSNP
rs1004358598 1385 dbSNP
rs957882991 1394 dbSNP
rs990163669 1396 dbSNP
rs1332627455 1401 dbSNP
rs10115 1408 dbSNP
rs1379839852 1420 dbSNP
rs1304371438 1427 dbSNP
rs775761918 1439 dbSNP
rs1015690006 1451 dbSNP
rs1345933293 1462 dbSNP
rs971183742 1463 dbSNP
rs1480196756 1469 dbSNP
rs570964378 1470 dbSNP
rs1261538908 1472 dbSNP
rs1224755491 1480 dbSNP
rs1322552067 1483 dbSNP
rs865885804 1489 dbSNP
rs1337220770 1491 dbSNP
rs1387544795 1492 dbSNP
rs1034132595 1494 dbSNP
rs16839134 1497 dbSNP
rs1299312517 1502 dbSNP
rs991391021 1507 dbSNP
rs549700839 1508 dbSNP
rs1284680629 1511 dbSNP
rs779110364 1523 dbSNP
rs1314536800 1524 dbSNP
rs1006382789 1530 dbSNP
rs1452171461 1536 dbSNP
rs538486055 1557 dbSNP
rs1463785848 1559 dbSNP
rs1804131 1562 dbSNP
rs1210855785 1563 dbSNP
rs1242952288 1564 dbSNP
rs924387952 1565 dbSNP
rs1189601891 1566 dbSNP
rs569431522 1567 dbSNP
rs13131 1571 dbSNP
rs1804129 1572 dbSNP
rs1427343912 1573 dbSNP
rs897568340 1574 dbSNP
rs943823954 1577 dbSNP
rs1480795736 1578 dbSNP
rs1261031546 1579 dbSNP
rs748313487 1580 dbSNP
rs1030377182 1581 dbSNP
rs976520343 1589 dbSNP
rs1320022753 1590 dbSNP
rs1345480484 1596 dbSNP
rs12817 1600 dbSNP
rs1261116710 1603 dbSNP
rs550543458 1609 dbSNP
rs1804135 1613 dbSNP
rs1435305262 1620 dbSNP
rs1291292950 1622 dbSNP
rs149159018 1630 dbSNP
rs1224685337 1636 dbSNP
rs773337775 1638 dbSNP
rs1032232570 1640 dbSNP
rs1804134 1654 dbSNP
rs957975470 1656 dbSNP
rs1327658121 1658 dbSNP
rs1804132 1660 dbSNP
rs770883702 1663 dbSNP
rs187212981 1665 dbSNP
rs1451315146 1666 dbSNP
rs1219559647 1668 dbSNP
rs1321686774 1669 dbSNP
rs1452341031 1674 dbSNP
rs1804130 1682 dbSNP
rs1248537822 1686 dbSNP
rs1020822928 1687 dbSNP
rs538312809 1690 dbSNP
rs1804122 1698 dbSNP
rs1804125 1701 dbSNP
rs1470385499 1708 dbSNP
rs888671047 1709 dbSNP
rs553831491 1710 dbSNP
rs1262304706 1718 dbSNP
rs1182810326 1723 dbSNP
rs1459804099 1726 dbSNP
rs1804128 1730 dbSNP
rs1244667723 1743 dbSNP
rs1804133 1744 dbSNP
rs1203910479 1746 dbSNP
rs571917599 1747 dbSNP
rs748951409 1755 dbSNP
rs542657584 1758 dbSNP
rs1804123 1765 dbSNP
rs906695843 1773 dbSNP
rs370151650 1775 dbSNP
rs937340467 1777 dbSNP
rs574385738 1788 dbSNP
rs1298969102 1794 dbSNP
rs1033752519 1800 dbSNP
rs1245780610 1811 dbSNP
rs1381042283 1820 dbSNP
rs1339036627 1827 dbSNP
rs1259779123 1835 dbSNP
rs895170793 1839 dbSNP
rs15096 1849 dbSNP
rs991517637 1857 dbSNP
rs1337323228 1858 dbSNP
rs1390773649 1862 dbSNP
rs1010834595 1865 dbSNP
rs1442631917 1867 dbSNP
rs1386876569 1870 dbSNP
rs1183922689 1871 dbSNP
rs1195125427 1873 dbSNP
rs1021505221 1876 dbSNP
rs909446803 1882 dbSNP
rs544964224 1884 dbSNP
rs1480668816 1898 dbSNP
rs562903036 1899 dbSNP
rs374434740 1900 dbSNP
rs1062686 1907 dbSNP
rs1031955833 1913 dbSNP
rs965227420 1914 dbSNP
rs1426269097 1919 dbSNP
rs73215943 1924 dbSNP
rs1335448286 1936 dbSNP
rs920989244 1938 dbSNP
rs932317816 1948 dbSNP
rs1393283946 1950 dbSNP
rs759004971 1961 dbSNP
rs983751355 1962 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugcgucUCGGGCUUUCGGGGGuca 5'
                :|||  |   |||||   
Target 5' ----uuGGCC--AUUACCCCC--- 3'
 		1 - 15
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000336375.5 | 3UTR | UUGGCCAUUACCCCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.415 2.2e-2 0.495 7.0e-3 24 Click to see details
GSE21849 B cell lymphoma -0.333 3.9e-2 -0.265 8.2e-2 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.279 8.8e-2 -0.328 5.5e-2 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.24 1.4e-1 -0.349 5.1e-2 23 Click to see details
GSE27834 Pluripotent stem cells -0.279 1.5e-1 -0.356 8.8e-2 16 Click to see details
GSE26953 Aortic valvular endothelial cells 0.209 1.6e-1 0.237 1.3e-1 24 Click to see details
GSE32688 Pancreatic cancer -0.17 1.8e-1 0.137 2.3e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.112 1.9e-1 -0.144 1.3e-1 64 Click to see details
GSE28260 Renal cortex and medulla 0.226 2.3e-1 0.264 1.9e-1 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.155 2.6e-1 -0.398 4.1e-2 20 Click to see details
GSE38226 Liver fibrosis 0.141 2.7e-1 -0.075 3.7e-1 21 Click to see details
GSE17498 Multiple myeloma 0.066 3.4e-1 0.174 1.4e-1 40 Click to see details
GSE17306 Multiple myeloma -0.035 4.1e-1 0.164 1.3e-1 49 Click to see details
GSE14794 Lymphoblastoid cells -0.019 4.3e-1 -0.112 1.5e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.019 4.3e-1 -0.112 1.5e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.019 4.3e-1 -0.112 1.5e-1 90 Click to see details
GSE14794 Lymphoblastoid cells -0.019 4.3e-1 -0.112 1.5e-1 90 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-637 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006147 SP7 Sp7 transcription factor 3 1
MIRT054906 COL4A1 collagen type IV alpha 1 chain 1 1
MIRT159142 NRBP1 nuclear receptor binding protein 1 2 2
MIRT358526 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT441490 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT443472 ACPP acid phosphatase, prostate 2 2
MIRT464631 UBE4A ubiquitination factor E4A 2 2
MIRT465259 TRIM44 tripartite motif containing 44 2 2
MIRT473975 LRRC58 leucine rich repeat containing 58 2 2
MIRT475168 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT477631 EFNA1 ephrin A1 2 2
MIRT480100 CALR calreticulin 2 2
MIRT483504 STMN3 stathmin 3 2 4
MIRT483735 THSD4 thrombospondin type 1 domain containing 4 2 2
MIRT483847 UNC5B unc-5 netrin receptor B 2 2
MIRT485973 RTBDN retbindin 2 2
MIRT486616 METTL6 methyltransferase like 6 2 2
MIRT487847 CLSTN1 calsyntenin 1 2 4
MIRT488675 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT489046 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT490612 SLC47A1 solute carrier family 47 member 1 2 4
MIRT490990 USP22 ubiquitin specific peptidase 22 2 2
MIRT492559 PRX periaxin 2 2
MIRT494667 ARL8A ADP ribosylation factor like GTPase 8A 2 2
MIRT495880 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT496778 ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif 14 2 2
MIRT499742 USH1G USH1 protein network component sans 2 4
MIRT500371 ZNF385A zinc finger protein 385A 2 2
MIRT503257 KIF18B kinesin family member 18B 2 2
MIRT504511 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT511940 FAM127B retrotransposon Gag like 8A 2 2
MIRT514606 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT527187 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT532494 HOXA13 homeobox A13 2 2
MIRT533504 TRIM71 tripartite motif containing 71 2 2
MIRT539171 AR androgen receptor 2 2
MIRT542735 RBFOX2 RNA binding protein, fox-1 homolog 2 2 2
MIRT544647 PHF8 PHD finger protein 8 2 4
MIRT546232 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 2
MIRT548372 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT555913 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT565381 TGOLN2 trans-golgi network protein 2 2 2
MIRT568954 RUNX3 runt related transcription factor 3 2 2
MIRT570205 RAP1GAP2 RAP1 GTPase activating protein 2 2 2
MIRT573599 CERS1 ceramide synthase 1 2 2
MIRT615364 CCNF cyclin F 2 2
MIRT616102 HOXB5 homeobox B5 2 2
MIRT619127 CD40LG CD40 ligand 2 2
MIRT634968 C8orf17 chromosome 8 open reading frame 17 2 2
MIRT646665 FNBP1 formin binding protein 1 2 2
MIRT649633 RASA4 RAS p21 protein activator 4 2 2
MIRT658443 FAM167B family with sequence similarity 167 member B 2 2
MIRT660237 BMP7 bone morphogenetic protein 7 2 2
MIRT669467 ATL3 atlastin GTPase 3 2 2
MIRT670557 SHISA2 shisa family member 2 2 2
MIRT671035 PCDHB2 protocadherin beta 2 2 2
MIRT684255 TBXA2R thromboxane A2 receptor 2 2
MIRT688619 CYBRD1 cytochrome b reductase 1 3 2
MIRT694346 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT695516 ALPI alkaline phosphatase, intestinal 2 2
MIRT697512 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT700133 RNF144B ring finger protein 144B 2 2
MIRT711667 TRMT5 tRNA methyltransferase 5 2 2
MIRT712156 TAOK1 TAO kinase 1 2 2
MIRT712463 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT720759 FAM193A family with sequence similarity 193 member A 2 2
MIRT731198 AKT1 AKT serine/threonine kinase 1 2 1
MIRT755463 PACS2 phosphofurin acidic cluster sorting protein 2 1 1
MIRT755522 FOXM1 forkhead box M1 3 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-637 Sorafenib 216239 NSC747971 approved sensitive High Hepatocellular Carcinoma tissue
hsa-miR-637 Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive Low Squamous Cell Carcinoma cell line (SCC-11)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-637 Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-637 Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (50nM)
hsa-miR-637 Tivantinib 11494412 NSC758242 resistant High Breast Cancer cell line (BT-20, BT-474, BT-549, CAMA-1, HCC1143, HCC1395, HCC1569, HCC1806, HCC-1937, HCC1954, HCC202, HCC38, HCC70, Hs578T, MCF-7, MDA-MB-175VII, MDA-MB-231, MDA-MB-361, MDA-MB-415, MDA-MB-436, MDA-MB-468, SKBR3, T47D, UACC812, EVSA-T, MPE-600 , SK-BR-
hsa-miR-637 Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HT-29, HCT-116)
hsa-miR-637 Sevoflurane 5206 NSC760367 approved sensitive Low Colorectal Cancer cell line
hsa-mir-637 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-637 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-637 Androstenedione+Anastrozole sensitive cell line (MCF-7)
hsa-mir-637 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-637 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-637 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-637 Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-637 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-637 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-637 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-637 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

Error report submission