miRTarBase - #MIRT443591


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pre-miRNA Information
pre-miRNA hsa-mir-500b   
Genomic Coordinates chrX: 50010672 - 50010750
Description Homo sapiens miR-500b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-500b-3p
Sequence 51| GCACCCAGGCAAGGAUUCUG |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs782140253 8 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZNF439   
Synonyms -
Description zinc finger protein 439
Transcript NM_152262   
Expression
Putative miRNA Targets on ZNF439
3'UTR of ZNF439
(miRNA target sites are highlighted)		 
>ZNF439|NM_152262|3'UTR
   1 ATATAAGATATATGGGAAACACTTTTATTCTGCCAAGTTATTTCAAACACATGAAAAAATTCACACTGGAGAGAAACCCT
  81 ATAAATGCAAGCAATGTGGTAAAGCCTTAATTGTTCCAGTTCCTTTCGATATCTAAAAGGACTCACAGTGGAGAAAAACT
 161 CTATGAGTGTAAGCAATGTGGGAAAGTCTTCAGATCTGTCAAGAACCTTTCAATTTATGAAAGGACACACACTGGAGAGA
 241 AACCCTATGAATGTAAGAAATGTGGAAAAGCGTTCCATAATTTCTCTTCTTTTCAAATACATGAAAGTTGCACAGAGGAG
 321 AGGCGCCCTAAGAATGTAAGCATTGTGGGAAAGCATTCATATCTGCCAAGATCGTTTGAATACATGCAAAACACACACTG
 401 GAGAGAAACCTATGAATGTAAGGAATGCAAACAAGCATTCAATTATTTTTCTTCCTTGCATATACATGAAAGGACTCATA
 481 CGAGAGAGAATCCGTATGAATGTAAGGATTGTGGGAAAGCATTCAGCTTGCTTAATTGCTTTCATAGACATGTAAAGACA
 561 CACCAGAAGGAAACCCTATGAATGTAAGCAATGTGGCAAAAGCTTTCACTTCTTCCAGTTCTTTTCAATATCATGAAAGG
 641 ACTCACACTGGGGAGAAACCGTATCAATGTAAGCAATGTGGGAAAGCCGTCAGATCAGCCTCAAGACTTCAAATGCATGG
 721 AAGCACTCACACTTGGCAGAAACTCTATGAATGTAAGCAGTATGGGAAAGCCTTCAGATCGGCTAGGATTCTTTGAATAC
 801 AAATAATGAATGTAAACAATTAACTGTTTATAATAACTGTATACTAACAAATGTTATTCTTTTTAAATAATTAAGAAGCT
 881 ATAATAAAATATCCATTGGTGTCATGTATTAGATCAAGCTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guCUUAGGAACG-GACCCacg 5'
            |:|  ||  | |||||   
Target 5' aaGGA--CTCACACTGGGgag 3'
 637 - 655 102.00 -11.10
2 
miRNA  3' guCUUAGGAACG----------GACCcacg 5'
            |||| | |||          ||||    
Target 5' ttGAATACATGCAAAACACACACTGGagag 3'
 376 - 405 88.00 -5.50
3 
miRNA  3' gucuuaggaacggACCCACg 5'
                       || ||| 
Target 5' gagaaaaactctaTGAGTGt 3'
 151 - 170 88.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31557645 8 COSMIC
COSN31574000 8 COSMIC
COSN30177258 45 COSMIC
COSN30458763 69 COSMIC
COSN30519975 70 COSMIC
COSN31492803 77 COSMIC
COSN30136543 85 COSMIC
COSN30513910 92 COSMIC
COSN30111295 97 COSMIC
COSN22262299 115 COSMIC
COSN28758045 117 COSMIC
COSN30624528 118 COSMIC
COSN13780028 128 COSMIC
COSN27006118 149 COSMIC
COSN30152752 162 COSMIC
COSN30447498 185 COSMIC
COSN31583641 186 COSMIC
COSN1210809 197 COSMIC
COSN30193327 220 COSMIC
COSN28681819 253 COSMIC
COSN31572976 254 COSMIC
COSN30115685 267 COSMIC
COSN5268441 277 COSMIC
COSN30120581 285 COSMIC
COSN30121540 290 COSMIC
COSN31529144 313 COSMIC
COSN31581056 390 COSMIC
COSN30501431 393 COSMIC
COSN31554685 468 COSMIC
COSN24458650 482 COSMIC
COSN17181908 526 COSMIC
COSN31606008 597 COSMIC
COSN31514311 635 COSMIC
COSN22990545 641 COSMIC
COSN31571929 667 COSMIC
COSN8552083 698 COSMIC
COSN32158767 703 COSMIC
COSN31561649 761 COSMIC
COSN30137877 763 COSMIC
COSN13780043 781 COSMIC
COSN23860911 781 COSMIC
COSN31584958 797 COSMIC
rs117322896 286 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371779004 1 dbSNP
rs1172315999 2 dbSNP
rs1346905328 4 dbSNP
rs375448782 10 dbSNP
rs749450046 12 dbSNP
rs1256520123 19 dbSNP
rs771519430 28 dbSNP
rs1165374079 29 dbSNP
rs755177603 33 dbSNP
rs1434185091 40 dbSNP
rs201648143 45 dbSNP
rs746201580 48 dbSNP
rs1232202049 54 dbSNP
rs1310236722 61 dbSNP
rs758259415 68 dbSNP
rs1232800613 72 dbSNP
rs1219479707 74 dbSNP
rs1340198714 75 dbSNP
rs1276325121 80 dbSNP
rs529956507 82 dbSNP
rs1363405788 83 dbSNP
rs1376553378 93 dbSNP
rs1302799772 97 dbSNP
rs1465026429 98 dbSNP
rs1356609617 107 dbSNP
rs777710617 111 dbSNP
rs183368203 114 dbSNP
rs563403021 128 dbSNP
rs939908378 129 dbSNP
rs770722228 132 dbSNP
rs1475918834 133 dbSNP
rs530509784 143 dbSNP
rs1350378595 144 dbSNP
rs1037179035 145 dbSNP
rs919649956 152 dbSNP
rs368824700 153 dbSNP
rs1044014299 154 dbSNP
rs1235162456 157 dbSNP
rs1341118182 159 dbSNP
rs1030222432 164 dbSNP
rs1489937169 177 dbSNP
rs1376237052 178 dbSNP
rs570376354 183 dbSNP
rs1465435332 187 dbSNP
rs1007362413 194 dbSNP
rs1399040253 201 dbSNP
rs755987652 214 dbSNP
rs150906399 221 dbSNP
rs1368540159 228 dbSNP
rs1186303896 229 dbSNP
rs1421929117 240 dbSNP
rs1252587329 243 dbSNP
rs1439655927 245 dbSNP
rs1179547993 248 dbSNP
rs72994216 253 dbSNP
rs1473002889 254 dbSNP
rs1255973345 256 dbSNP
rs1010439299 258 dbSNP
rs78704590 261 dbSNP
rs1215754877 270 dbSNP
rs555161098 272 dbSNP
rs762466606 273 dbSNP
rs996281436 276 dbSNP
rs1319182740 282 dbSNP
rs1310665726 283 dbSNP
rs117322896 286 dbSNP
rs1375114088 290 dbSNP
rs535696022 300 dbSNP
rs1423539476 308 dbSNP
rs926860712 309 dbSNP
rs938296335 310 dbSNP
rs1388141536 313 dbSNP
rs1053954986 314 dbSNP
rs1391024491 317 dbSNP
rs138404339 320 dbSNP
rs187871947 325 dbSNP
rs1042464727 326 dbSNP
rs1159158806 330 dbSNP
rs1327398407 331 dbSNP
rs1019562543 335 dbSNP
rs757795549 337 dbSNP
rs901274420 345 dbSNP
rs961596258 346 dbSNP
rs998160093 348 dbSNP
rs1452343539 357 dbSNP
rs1050200828 367 dbSNP
rs889031946 369 dbSNP
rs539564754 372 dbSNP
rs558202710 374 dbSNP
rs74454158 375 dbSNP
rs550592362 394 dbSNP
rs573166324 405 dbSNP
rs1025997610 413 dbSNP
rs1240012609 418 dbSNP
rs116273286 428 dbSNP
rs931033418 433 dbSNP
rs1306014852 438 dbSNP
rs1234430570 443 dbSNP
rs1331288108 446 dbSNP
rs1245459740 449 dbSNP
rs1322501881 456 dbSNP
rs1384769916 461 dbSNP
rs979852677 462 dbSNP
rs926944884 478 dbSNP
rs79495694 482 dbSNP
rs574764307 494 dbSNP
rs542081237 495 dbSNP
rs1478250642 503 dbSNP
rs1249718246 516 dbSNP
rs1196993680 518 dbSNP
rs892014210 526 dbSNP
rs946293713 535 dbSNP
rs10405375 536 dbSNP
rs1487558800 541 dbSNP
rs1283128205 546 dbSNP
rs1033801884 547 dbSNP
rs546921869 550 dbSNP
rs1443797447 551 dbSNP
rs1230603749 552 dbSNP
rs959630928 560 dbSNP
rs990167177 563 dbSNP
rs1278212039 564 dbSNP
rs530706233 584 dbSNP
rs867886251 585 dbSNP
rs143003329 592 dbSNP
rs766770281 597 dbSNP
rs1415017817 603 dbSNP
rs570636623 604 dbSNP
rs1170661001 630 dbSNP
rs922649586 631 dbSNP
rs1008865206 632 dbSNP
rs564165026 643 dbSNP
rs1476897060 644 dbSNP
rs1259761177 660 dbSNP
rs1015340306 661 dbSNP
rs1442417580 668 dbSNP
rs539211773 677 dbSNP
rs1197940660 680 dbSNP
rs934106437 689 dbSNP
rs1049749753 690 dbSNP
rs1217433395 694 dbSNP
rs1402310973 697 dbSNP
rs1397051965 698 dbSNP
rs1285484817 705 dbSNP
rs1448659662 711 dbSNP
rs889809554 717 dbSNP
rs1339860922 721 dbSNP
rs943287871 730 dbSNP
rs952571805 731 dbSNP
rs1401246536 732 dbSNP
rs1170215525 734 dbSNP
rs979821638 749 dbSNP
rs927081646 751 dbSNP
rs1182582282 763 dbSNP
rs1037553331 767 dbSNP
rs1472724749 771 dbSNP
rs1236234457 772 dbSNP
rs1452420637 779 dbSNP
rs755022786 781 dbSNP
rs10403439 782 dbSNP
rs1238003660 783 dbSNP
rs912909181 788 dbSNP
rs1315745863 808 dbSNP
rs993256266 808 dbSNP
rs1291382326 809 dbSNP
rs1228406110 818 dbSNP
rs546182901 819 dbSNP
rs1355509160 825 dbSNP
rs1026138859 828 dbSNP
rs946292512 830 dbSNP
rs796711276 838 dbSNP
rs1377323818 845 dbSNP
rs1330504049 850 dbSNP
rs1444826161 854 dbSNP
rs904688310 868 dbSNP
rs1165487128 870 dbSNP
rs1404869920 871 dbSNP
rs1345849054 874 dbSNP
rs1160949467 883 dbSNP
rs1412199133 883 dbSNP
rs932172258 886 dbSNP
rs1380068241 900 dbSNP
rs1050590966 902 dbSNP
rs751467787 905 dbSNP
rs369374680 906 dbSNP
rs906278201 917 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucuuaGGAACGGACCCAcg 5'
                ||||| ||||||  
Target 5' --uuggCCUUGGCUGGGU-- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BAC
Disease MIMAT0027032
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020023. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucuuaGGAACGGACCCAcg 5'
                ||||| ||||||  
Target 5' --uuggCCUUGGCUGGGU-- 3'
 		1 - 16
Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
CLIP-seq Support 1 for dataset GSM1020023
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BAC / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000304030.2 | 3UTR | UUGGCCUUGGCUGGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000304030.2 | 3UTR | UUGGCCUUGGCUGGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
172 hsa-miR-500b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059905 HDGF heparin binding growth factor 2 4
MIRT235394 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 4
MIRT442246 PYGO1 pygopus family PHD finger 1 2 2
MIRT443591 ZNF439 zinc finger protein 439 2 4
MIRT453280 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT463540 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT465589 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT469462 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT485449 KCTD15 potassium channel tetramerization domain containing 15 2 4
MIRT486682 WDR81 WD repeat domain 81 2 2
MIRT489078 POLM DNA polymerase mu 2 2
MIRT493734 GREM2 gremlin 2, DAN family BMP antagonist 2 2
MIRT494872 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT496130 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT496489 CHMP3 charged multivesicular body protein 3 2 2
MIRT496924 CLMN calmin 2 2
MIRT497297 TMEM119 transmembrane protein 119 2 2
MIRT499103 AGRN agrin 2 2
MIRT508979 CXorf38 chromosome X open reading frame 38 2 2
MIRT509911 NIPAL1 NIPA like domain containing 1 2 2
MIRT512820 ARRDC2 arrestin domain containing 2 2 4
MIRT512827 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT515360 MRPL52 mitochondrial ribosomal protein L52 2 2
MIRT516610 TRIM58 tripartite motif containing 58 2 2
MIRT517053 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT517637 ZNF491 zinc finger protein 491 2 2
MIRT518270 LEAP2 liver enriched antimicrobial peptide 2 2 2
MIRT518625 STAR steroidogenic acute regulatory protein 2 2
MIRT518887 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT519026 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 2
MIRT520365 UBE2G2 ubiquitin conjugating enzyme E2 G2 2 2
MIRT521106 SLC1A5 solute carrier family 1 member 5 2 2
MIRT521943 PHC3 polyhomeotic homolog 3 2 2
MIRT522253 NPEPPS aminopeptidase puromycin sensitive 2 2
MIRT522853 KIAA1551 KIAA1551 2 2
MIRT522868 KIAA1549 KIAA1549 2 2
MIRT524207 DDX19B DEAD-box helicase 19B 2 2
MIRT526004 ARHGAP27 Rho GTPase activating protein 27 2 2
MIRT527769 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT527827 TMEM74B transmembrane protein 74B 2 2
MIRT527861 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT528040 WT1 Wilms tumor 1 2 2
MIRT529802 ZDHHC8 zinc finger DHHC-type containing 8 2 2
MIRT531723 TARS threonyl-tRNA synthetase 2 2
MIRT531996 BARD1 BRCA1 associated RING domain 1 2 2
MIRT533338 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT533621 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT533652 TMOD2 tropomodulin 2 2 2
MIRT534397 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2 2
MIRT538686 CCDC80 coiled-coil domain containing 80 2 2
MIRT540444 RBM43 RNA binding motif protein 43 2 2
MIRT542586 ZC3H12C zinc finger CCCH-type containing 12C 2 8
MIRT542796 PLEKHA3 pleckstrin homology domain containing A3 2 4
MIRT542991 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT544424 ZNF460 zinc finger protein 460 2 4
MIRT545740 ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 2 4
MIRT552618 ZBTB8A zinc finger and BTB domain containing 8A 2 2
MIRT554456 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT569663 PRIM1 DNA primase subunit 1 2 2
MIRT569924 PCSK9 proprotein convertase subtilisin/kexin type 9 2 2
MIRT570140 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT573558 TMEM120B transmembrane protein 120B 2 2
MIRT574282 OPRD1 opioid receptor delta 1 2 2
MIRT575335 Fbxo6 F-box protein 6 2 2
MIRT607057 IDS iduronate 2-sulfatase 2 2
MIRT607078 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607500 HEBP2 heme binding protein 2 2 2
MIRT607530 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT607808 RHBDL2 rhomboid like 2 2 2
MIRT608079 ZFP14 ZFP14 zinc finger protein 2 2
MIRT609119 NUDT3 nudix hydrolase 3 2 2
MIRT609745 PTCH1 patched 1 2 2
MIRT612904 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 2
MIRT618720 PCSK2 proprotein convertase subtilisin/kexin type 2 2 2
MIRT618778 HLA-E major histocompatibility complex, class I, E 2 2
MIRT619015 SLC2A6 solute carrier family 2 member 6 2 2
MIRT623223 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT623819 GEMIN6 gem nuclear organelle associated protein 6 2 2
MIRT625704 OPTN optineurin 2 2
MIRT626437 CHDH choline dehydrogenase 2 2
MIRT628087 KAT7 lysine acetyltransferase 7 2 2
MIRT628936 APOB apolipoprotein B 2 2
MIRT633543 PGBD5 piggyBac transposable element derived 5 2 2
MIRT634348 SGOL1 shugoshin 1 2 2
MIRT634611 KIAA1919 major facilitator superfamily domain containing 4B 2 2
MIRT635243 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT636681 BTLA B and T lymphocyte associated 2 2
MIRT636923 ZNF845 zinc finger protein 845 2 2
MIRT637606 ZNF554 zinc finger protein 554 2 2
MIRT639242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT640835 POLR3A RNA polymerase III subunit A 2 2
MIRT642098 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT643087 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT643934 C17orf104 meiosis specific with coiled-coil domain 2 2
MIRT644353 FXN frataxin 2 2
MIRT645628 SF3A3 splicing factor 3a subunit 3 2 2
MIRT645754 FAM213A family with sequence similarity 213 member A 2 2
MIRT646329 MVB12B multivesicular body subunit 12B 2 2
MIRT646817 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT647019 ADCY2 adenylate cyclase 2 2 2
MIRT647621 IGSF9B immunoglobulin superfamily member 9B 2 2
MIRT648517 PIGG phosphatidylinositol glycan anchor biosynthesis class G 2 2
MIRT648871 ABCA6 ATP binding cassette subfamily A member 6 2 2
MIRT649620 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650062 CCDC134 coiled-coil domain containing 134 2 2
MIRT650734 TNFSF8 TNF superfamily member 8 2 2
MIRT652389 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT654352 RBM27 RNA binding motif protein 27 2 2
MIRT655796 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT657329 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT657734 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT660613 ANO6 anoctamin 6 2 2
MIRT661243 ARL17B ADP ribosylation factor like GTPase 17B 2 2
MIRT662245 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662921 MED18 mediator complex subunit 18 2 2
MIRT662963 JPH2 junctophilin 2 2 2
MIRT663347 ZNF74 zinc finger protein 74 2 2
MIRT663528 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT663547 CCR6 C-C motif chemokine receptor 6 2 2
MIRT663977 ZNF786 zinc finger protein 786 2 2
MIRT664084 METTL2B methyltransferase like 2B 2 2
MIRT664358 C16orf45 chromosome 16 open reading frame 45 2 2
MIRT664421 TIGD6 tigger transposable element derived 6 2 2
MIRT664476 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT664979 TDRD1 tudor domain containing 1 2 2
MIRT665128 PYCRL pyrroline-5-carboxylate reductase 3 2 2
MIRT666259 SLC31A1 solute carrier family 31 member 1 2 2
MIRT666321 SLC16A10 solute carrier family 16 member 10 2 2
MIRT666881 POLQ DNA polymerase theta 2 2
MIRT668469 FADS6 fatty acid desaturase 6 2 2
MIRT669554 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT669835 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT670185 CCDC142 coiled-coil domain containing 142 2 2
MIRT672020 PXMP4 peroxisomal membrane protein 4 2 2
MIRT672070 KIAA0930 KIAA0930 2 2
MIRT672475 RTTN rotatin 2 2
MIRT672851 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT673090 AK1 adenylate kinase 1 2 2
MIRT673581 KDELC2 KDEL motif containing 2 2 2
MIRT674586 SLC35B4 solute carrier family 35 member B4 2 2
MIRT675001 STRN3 striatin 3 2 2
MIRT679018 MTMR10 myotubularin related protein 10 2 2
MIRT679680 STAT3 signal transducer and activator of transcription 3 2 2
MIRT682833 FLG2 filaggrin family member 2 2 2
MIRT682886 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT683442 AP3B2 adaptor related protein complex 3 beta 2 subunit 2 2
MIRT687040 RNF115 ring finger protein 115 2 2
MIRT691957 RHOH ras homolog family member H 2 2
MIRT694625 ZFPM1 zinc finger protein, FOG family member 1 2 2
MIRT695637 SLC26A2 solute carrier family 26 member 2 2 2
MIRT697640 WRN Werner syndrome RecQ like helicase 2 2
MIRT702009 MIDN midnolin 2 2
MIRT702034 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT704789 CDK6 cyclin dependent kinase 6 2 2
MIRT705728 AMMECR1L AMMECR1 like 2 2
MIRT705879 ADM adrenomedullin 2 2
MIRT706220 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT708418 CERS4 ceramide synthase 4 2 2
MIRT709114 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709595 ITPA inosine triphosphatase 2 2
MIRT710945 MRPL45 mitochondrial ribosomal protein L45 2 2
MIRT712345 NLN neurolysin 2 2
MIRT712530 CYTH2 cytohesin 2 2 2
MIRT714019 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT717287 ARMC12 armadillo repeat containing 12 2 2
MIRT717733 FGF1 fibroblast growth factor 1 2 2
MIRT718083 CLIC5 chloride intracellular channel 5 2 2
MIRT718562 MUC20 mucin 20, cell surface associated 2 2
MIRT721639 MYLK3 myosin light chain kinase 3 2 2
MIRT722632 C8A complement C8 alpha chain 2 2
MIRT723177 CDCA4 cell division cycle associated 4 2 2
MIRT725523 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-500b Methotrexate 126941 NSC740 approved resistant cell line (W1)
hsa-miR-500b-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (AsPC-1)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-500b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-500b-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-500b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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