miRTarBase - #MIRT443785


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pre-miRNA Information
pre-miRNA hsa-mir-2116   
Genomic Coordinates chr15: 59171183 - 59171262
Description Homo sapiens miR-2116 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2116-5p
Sequence 14| GGUUCUUAGCAUAGGAGGUCU |34
Evidence Experimental
Experiments 454
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 - 59171242 29233923 MiREDiBase
A-to-I 13 15 - 59171237 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1217966510 1 dbSNP
rs1170901508 3 dbSNP
rs1364783161 5 dbSNP
rs1240890962 11 dbSNP
rs537360898 13 dbSNP
rs776323490 17 dbSNP
Putative Targets

Gene Information
Gene Symbol ST13   
Synonyms AAG2, FAM10A1, FAM10A4, HIP, HOP, HSPABP, HSPABP1, P48, PRO0786, SNC6
Description ST13, Hsp70 interacting protein
Transcript NM_003932   
Expression
Putative miRNA Targets on ST13
3'UTR of ST13
(miRNA target sites are highlighted)		 
>ST13|NM_003932|3'UTR
   1 TGTCCTTCTGATAAATAAAGCCCTTGCTGAAGGAAAAGCAACCTAGATCACCTTATGGATGTCGCAATAATACAAACCAG
  81 TGTACCTCTGACCTTCTCATCAAGAGAGCTGGGGTGCTTTGAAGATAATCCCTACCCCTCTCCCCCAAATGCAGCTGAAG
 161 CATTTTACAGTGGTTTGCCATTAGGGTATTCATTCAGATAATGTTTTCCTACTAGGAATTACAAACTTTAAACACTTTTT
 241 AAATCTTCAAAATATTTAAAACAAATTTAAAGGGCCTGTTAATTCTTATATTTTTCTTTACTAATCATTTTGGATTTTTT
 321 TCTTTGAATTATTGGCAGGGAATATACTTATGTATGGAAGATTACTGCTCTGAGTGAAATAAAAGTTATTAGTGCGAGGC
 401 AAACATAACTCATTTGAGGATAAAGTTTGTGTTGGATATGTGGTTCCTGATGCATTTTGACTTGTCTTTTTAAATGCTTT
 481 ATCTTTTTCTTTAAAGATTTATTTCAATAAAACTAATTGGGACCACCCGTATTTCAGTAGGACCTGGGTAGGGATTGGAA
 561 GTACTTGGCAGGGCAGCAGCAATCTTGCTGTGTTTGATATAACATGCATCCTTGGGCAGGTTGCCCTTAAATCTTACACT
 641 GTGGTGAAGGGATGTTTTTTTTGTAATGCTGCAGTAGAGTTGGAGTACTTAGTTCTCTTGTTGTCCAGTATATCTAATAA
 721 GTGTTTTTCATATTATTTCCACGTAAGGGAAATAAGGTAGTACTTTTCTTTTTATATTTCTATGCTTAAAATTCTCTTTC
 801 CTAGTCAAAAATTGCCCAAATCTGTGTTTGCTTTCTGCTTGCTACATTTGTCTCCCTTACTTTTCTTGAGCTAAAGACAG
 881 GCTTTTTCCACCGGCATCATCACTGCTATCATCATTAACAGCGTAATTATACAAGCATATTTAATGCTGAGTTTAATTTA
 961 ATATGTAATACATATGGTAATTGTAGGGTAATACCCACAACAACTGTAGTTTCTTACTTGGCCAAGAGAATGCTTATTTA
1041 AGTGTTAGACTTCCATTCTGGCAAAATCTTGCCTTATCAGAAGACATTGGAAAGAGGGATTCCCTTTGGTGTTTGGTCTT
1121 CTACTTAGAAAAACCTATTGCAGTTAGTTTATCTTGTAGTATTCATCTTTGTATTCTGAAGATAAGGTTTGAATTAAATT
1201 GATACACACAGAGGGGAACCGATTTTTTTTATCCAATGTGAATTATAAATGAGATAATCCACAGTTATTCATTGTGGAGT
1281 TGTTGAGACTATGAAAGACTCATTGTCTTTGTATTCAGCTCTTAAATAGTGTAACTATATCCCCACCTCTGCTTGCTTTC
1361 TTTCCCTCCCCTCCAATGATAAAGAAAATGATAAATTTTCTGTTGTGCATTCAATTCTTATTTTAAATAAGACTAAGTAT
1441 AGGCATTGTACCTGACATTGCTACGTTTCTACCAGTGTTTCAATTTAAAGTGCTAGTGTTTAAAAACATTTTCAAGGGAT
1521 AAGGCCTTCTGTACTTTGCTTATTTGAAGAATCAGTGGTAGGAGCAGTGAAGTAAATTCTATGGAGTACATTTCTAAAAT
1601 ACCACATTTCTGAAATCATAAATAAGTTTATTCAGGTTCTAACCCTTTGCTGTACACAAGCAGACAGAAATGCATCTGTT
1681 ACATAAATGAGAAAAAGCTATTATGCTGATGGAGCATGCTTTTTAAATCCTTTAAAAACACTCACCATATAAACTTGCAT
1761 TTGAGCTTGTGTGTTCTTTTGTTAATGTGTAGAGTTCTCCTTTCTCGAAATTGCCAGTGTGTACTTGGCTTAACTCAAGA
1841 ACAGTTTCTTCTGGATTCCTTATTTGATTTATTTAACCTAATTATATTCTAATATTGCAAATATTACCATAAGTGGGTAA
1921 AAGTAAAATTCCTCTTCTGAAAATGTGTCCTGTGCTTTTAGATTTTTAAATTCCATAATATACATTCTTAATTTTCAACT
2001 CAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuGGAGGAUACGAUUCUUGg 5'
             ::|||||  |||:|||: 
Target 5' tgtTTTCCTA--CTAGGAATt 3'
 202 - 220 130.00 -12.60
2 
miRNA  3' ucUGGA--GGAUACGAUUCUUGg 5'
            ||:|  |:||  : |||||| 
Target 5' gtACTTGGCTTAACTCAAGAACa 3'
 1821 - 1843 125.00 -7.60
3 
miRNA  3' ucuGGAGGAUACGA-UUCUUgg 5'
             ||||| ||| | |||||  
Target 5' tccCCTCCAATGATAAAGAAaa 3'
 1367 - 1388 122.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26560231 3 COSMIC
COSN31486591 29 COSMIC
COSN31485120 32 COSMIC
COSN30179332 41 COSMIC
COSN31593094 67 COSMIC
COSN20121462 89 COSMIC
COSN30487493 93 COSMIC
COSN31610123 171 COSMIC
COSN31543307 395 COSMIC
COSN31491005 396 COSMIC
COSN26669034 451 COSMIC
COSN26669856 471 COSMIC
COSN31523875 501 COSMIC
COSN31488235 519 COSMIC
COSN26646267 528 COSMIC
COSN26668155 561 COSMIC
COSN31539795 619 COSMIC
COSN5858971 652 COSMIC
COSN31589889 681 COSMIC
COSN28003062 1222 COSMIC
COSN9166285 1359 COSMIC
COSN16608749 1730 COSMIC
COSN16304210 1761 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs12373981 3 dbSNP
rs1325334826 4 dbSNP
rs754709867 8 dbSNP
rs1323498063 13 dbSNP
rs139004215 15 dbSNP
rs1382430306 17 dbSNP
rs769083328 20 dbSNP
rs1246948482 23 dbSNP
rs765974812 25 dbSNP
rs1372290586 26 dbSNP
rs534991835 32 dbSNP
rs934026526 34 dbSNP
rs1331141340 38 dbSNP
rs750085667 39 dbSNP
rs761288465 42 dbSNP
rs776086414 46 dbSNP
rs1466804948 49 dbSNP
rs1423173116 55 dbSNP
rs975491044 56 dbSNP
rs1261525715 59 dbSNP
rs145131177 63 dbSNP
rs984260497 65 dbSNP
rs555820690 67 dbSNP
rs1428147612 79 dbSNP
rs12373983 80 dbSNP
rs12373980 81 dbSNP
rs1417417364 87 dbSNP
rs1195967038 88 dbSNP
rs770708625 98 dbSNP
rs1026354559 101 dbSNP
rs536104237 106 dbSNP
rs1221451030 111 dbSNP
rs142954064 123 dbSNP
rs1267004188 133 dbSNP
rs1231369041 134 dbSNP
rs1271406559 142 dbSNP
rs1318783505 148 dbSNP
rs11704863 155 dbSNP
rs550461391 161 dbSNP
rs532460208 162 dbSNP
rs1306591868 177 dbSNP
rs1485105566 178 dbSNP
rs1202476691 196 dbSNP
rs569974319 197 dbSNP
rs1475200100 198 dbSNP
rs1186398975 203 dbSNP
rs1413584306 211 dbSNP
rs1275701909 218 dbSNP
rs1157938356 226 dbSNP
rs1219990069 229 dbSNP
rs1063981 234 dbSNP
rs1467393750 235 dbSNP
rs1341647079 241 dbSNP
rs1283274018 248 dbSNP
rs1403653379 250 dbSNP
rs1032061406 252 dbSNP
rs999770404 258 dbSNP
rs902343294 264 dbSNP
rs1224354484 268 dbSNP
rs12373982 275 dbSNP
rs1461629156 289 dbSNP
rs1342355191 291 dbSNP
rs1315427573 292 dbSNP
rs933241955 296 dbSNP
rs1172875591 297 dbSNP
rs1466272225 307 dbSNP
rs1424228788 320 dbSNP
rs1198522560 322 dbSNP
rs900392502 322 dbSNP
rs1405155848 323 dbSNP
rs1434596180 332 dbSNP
rs1039690514 334 dbSNP
rs1173845481 334 dbSNP
rs1432583058 342 dbSNP
rs1309790392 343 dbSNP
rs942669218 343 dbSNP
rs1431371705 347 dbSNP
rs765161156 351 dbSNP
rs12373978 352 dbSNP
rs1236818932 354 dbSNP
rs1304389953 360 dbSNP
rs1347633267 361 dbSNP
rs1232471097 363 dbSNP
rs984167255 370 dbSNP
rs571187981 372 dbSNP
rs548476101 387 dbSNP
rs189969667 392 dbSNP
rs918749858 395 dbSNP
rs528067864 396 dbSNP
rs760662641 408 dbSNP
rs1169501481 416 dbSNP
rs184648677 420 dbSNP
rs1409353180 422 dbSNP
rs1168194511 425 dbSNP
rs542713527 428 dbSNP
rs971022895 429 dbSNP
rs1314489921 433 dbSNP
rs1443130754 442 dbSNP
rs34830463 443 dbSNP
rs71200619 443 dbSNP
rs71328753 443 dbSNP
rs1370436714 453 dbSNP
rs530484302 465 dbSNP
rs1438974291 470 dbSNP
rs916806309 472 dbSNP
rs1391224767 502 dbSNP
rs990493915 506 dbSNP
rs957654376 507 dbSNP
rs1032135907 513 dbSNP
rs1336328632 517 dbSNP
rs1213704051 518 dbSNP
rs1271985254 528 dbSNP
rs999277137 528 dbSNP
rs563924743 529 dbSNP
rs1464438602 538 dbSNP
rs1474936475 539 dbSNP
rs1379347941 542 dbSNP
rs1463078746 547 dbSNP
rs545241573 550 dbSNP
rs1176481740 555 dbSNP
rs1393810166 564 dbSNP
rs1418352994 567 dbSNP
rs148221479 574 dbSNP
rs1327415083 575 dbSNP
rs1430390717 576 dbSNP
rs771982076 577 dbSNP
rs554775987 582 dbSNP
rs1357988104 587 dbSNP
rs1234425755 590 dbSNP
rs997727386 591 dbSNP
rs747897014 596 dbSNP
rs541475590 597 dbSNP
rs1206559506 600 dbSNP
rs1038885566 611 dbSNP
rs574079193 612 dbSNP
rs778277005 615 dbSNP
rs1457960318 622 dbSNP
rs192856570 626 dbSNP
rs1198282982 630 dbSNP
rs1347721355 633 dbSNP
rs888438579 646 dbSNP
rs190049341 649 dbSNP
rs185113649 651 dbSNP
rs1471825138 663 dbSNP
rs1160532043 667 dbSNP
rs1385859236 677 dbSNP
rs1351885527 684 dbSNP
rs192500202 692 dbSNP
rs1296802624 694 dbSNP
rs1377632840 695 dbSNP
rs1286351668 697 dbSNP
rs918643752 700 dbSNP
rs1240486491 707 dbSNP
rs1046573625 710 dbSNP
rs770019372 714 dbSNP
rs1221702466 717 dbSNP
rs1282260293 732 dbSNP
rs1485854787 734 dbSNP
rs949551050 739 dbSNP
rs916837542 742 dbSNP
rs1440776043 743 dbSNP
rs1184162877 745 dbSNP
rs1364447416 749 dbSNP
rs1469865193 764 dbSNP
rs143058803 774 dbSNP
rs1397304273 780 dbSNP
rs571249049 782 dbSNP
rs546488186 793 dbSNP
rs1400606348 801 dbSNP
rs534560245 804 dbSNP
rs1393640926 811 dbSNP
rs924929946 812 dbSNP
rs1334636928 831 dbSNP
rs1439619726 840 dbSNP
rs373527267 842 dbSNP
rs772433609 844 dbSNP
rs978271873 859 dbSNP
rs1348342625 860 dbSNP
rs1303416861 863 dbSNP
rs149037812 873 dbSNP
rs1341463732 876 dbSNP
rs966497571 892 dbSNP
rs1030459201 893 dbSNP
rs1437277293 896 dbSNP
rs1177024260 903 dbSNP
rs997360498 910 dbSNP
rs964511116 917 dbSNP
rs1173477741 918 dbSNP
rs548670420 922 dbSNP
rs530654857 923 dbSNP
rs1168966058 932 dbSNP
rs1395176399 933 dbSNP
rs1463555193 936 dbSNP
rs1327508211 938 dbSNP
rs1017508479 940 dbSNP
rs1439695945 944 dbSNP
rs1298990392 946 dbSNP
rs1006081477 951 dbSNP
rs888471165 965 dbSNP
rs563212117 975 dbSNP
rs1228107117 976 dbSNP
rs1048408659 983 dbSNP
rs551983668 987 dbSNP
rs994547311 999 dbSNP
rs1443703445 1000 dbSNP
rs1256256295 1003 dbSNP
rs1275117134 1005 dbSNP
rs566279357 1005 dbSNP
rs1469119188 1008 dbSNP
rs897246793 1009 dbSNP
rs1265755544 1010 dbSNP
rs1430621895 1027 dbSNP
rs1194536927 1028 dbSNP
rs1046880776 1031 dbSNP
rs949573258 1037 dbSNP
rs916743806 1058 dbSNP
rs1394554100 1065 dbSNP
rs1460636466 1077 dbSNP
rs533554614 1079 dbSNP
rs1055414847 1086 dbSNP
rs1282709612 1094 dbSNP
rs936891444 1096 dbSNP
rs1247066033 1097 dbSNP
rs925494238 1098 dbSNP
rs977790739 1104 dbSNP
rs560135962 1110 dbSNP
rs1235046272 1114 dbSNP
rs1294985976 1120 dbSNP
rs1335514434 1121 dbSNP
rs1399272407 1125 dbSNP
rs1487057717 1137 dbSNP
rs1206161138 1138 dbSNP
rs746100446 1162 dbSNP
rs541747934 1164 dbSNP
rs1261453116 1167 dbSNP
rs923082975 1168 dbSNP
rs1358603252 1174 dbSNP
rs976229262 1182 dbSNP
rs556622032 1190 dbSNP
rs1474568434 1192 dbSNP
rs1420152917 1202 dbSNP
rs1017373111 1205 dbSNP
rs757366972 1211 dbSNP
rs951977084 1211 dbSNP
rs1288126357 1212 dbSNP
rs747510275 1213 dbSNP
rs1026615983 1214 dbSNP
rs547558525 1220 dbSNP
rs1313368151 1221 dbSNP
rs1368494612 1223 dbSNP
rs144879539 1224 dbSNP
rs1227748045 1226 dbSNP
rs1477113860 1230 dbSNP
rs1025092438 1231 dbSNP
rs1285808951 1231 dbSNP
rs897146143 1231 dbSNP
rs1487491833 1233 dbSNP
rs1213673397 1234 dbSNP
rs1013665264 1236 dbSNP
rs1485059572 1241 dbSNP
rs1179672306 1249 dbSNP
rs562129405 1251 dbSNP
rs543431567 1254 dbSNP
rs895342044 1257 dbSNP
rs1157877114 1261 dbSNP
rs1378284438 1262 dbSNP
rs1055321232 1264 dbSNP
rs1174192385 1268 dbSNP
rs1288184133 1269 dbSNP
rs1445714432 1278 dbSNP
rs1211820150 1286 dbSNP
rs1357348736 1290 dbSNP
rs936786375 1291 dbSNP
rs904106231 1292 dbSNP
rs1216920733 1303 dbSNP
rs748847641 1305 dbSNP
rs1280085886 1307 dbSNP
rs1400555508 1313 dbSNP
rs576515768 1335 dbSNP
rs1480650693 1337 dbSNP
rs945095416 1341 dbSNP
rs975827663 1342 dbSNP
rs1321374481 1345 dbSNP
rs557962106 1359 dbSNP
rs1187743328 1360 dbSNP
rs1412728724 1363 dbSNP
rs1391061189 1373 dbSNP
rs1356380713 1376 dbSNP
rs1169303780 1384 dbSNP
rs1330941952 1388 dbSNP
rs910273030 1396 dbSNP
rs187731342 1407 dbSNP
rs779776125 1409 dbSNP
rs1463665658 1417 dbSNP
rs1426393580 1418 dbSNP
rs771464645 1421 dbSNP
rs1443358052 1436 dbSNP
rs1367301282 1440 dbSNP
rs1478006004 1440 dbSNP
rs577421244 1445 dbSNP
rs1201529401 1459 dbSNP
rs1275661304 1463 dbSNP
rs1307581939 1464 dbSNP
rs1452375213 1473 dbSNP
rs1250164281 1474 dbSNP
rs1026271341 1483 dbSNP
rs1255595804 1491 dbSNP
rs1469574913 1492 dbSNP
rs972385518 1496 dbSNP
rs1245946464 1497 dbSNP
rs961431488 1498 dbSNP
rs1188222610 1501 dbSNP
rs1420062330 1502 dbSNP
rs1196818592 1516 dbSNP
rs1170130987 1518 dbSNP
rs1398171228 1519 dbSNP
rs1463245150 1527 dbSNP
rs749367980 1537 dbSNP
rs1025380489 1544 dbSNP
rs1320024087 1552 dbSNP
rs1272433244 1553 dbSNP
rs777976734 1562 dbSNP
rs1258804613 1563 dbSNP
rs1275802426 1571 dbSNP
rs895236920 1581 dbSNP
rs1033722642 1582 dbSNP
rs552710540 1590 dbSNP
rs1449661008 1594 dbSNP
rs1344242973 1602 dbSNP
rs1272832034 1604 dbSNP
rs1438391904 1615 dbSNP
rs1191372778 1616 dbSNP
rs1421611313 1625 dbSNP
rs1331320108 1631 dbSNP
rs1476199378 1633 dbSNP
rs1164063708 1637 dbSNP
rs1330328911 1638 dbSNP
rs1403802710 1643 dbSNP
rs1001071224 1651 dbSNP
rs904009648 1672 dbSNP
rs1444140752 1673 dbSNP
rs534623242 1680 dbSNP
rs532669219 1682 dbSNP
rs1296838039 1683 dbSNP
rs1356835528 1693 dbSNP
rs1170798179 1700 dbSNP
rs1283087283 1701 dbSNP
rs376218603 1703 dbSNP
rs535969412 1703 dbSNP
rs902069971 1704 dbSNP
rs1174676589 1713 dbSNP
rs1040029158 1716 dbSNP
rs1478595709 1746 dbSNP
rs1237972157 1747 dbSNP
rs1214386514 1749 dbSNP
rs1259454998 1758 dbSNP
rs369794843 1764 dbSNP
rs1459287070 1773 dbSNP
rs1238813250 1777 dbSNP
rs375224936 1780 dbSNP
rs5758098 1786 dbSNP
rs910306020 1789 dbSNP
rs1381342950 1792 dbSNP
rs1048795781 1798 dbSNP
rs569771493 1806 dbSNP
rs551495768 1807 dbSNP
rs1397111814 1817 dbSNP
rs533010740 1824 dbSNP
rs1345382423 1834 dbSNP
rs1023600395 1836 dbSNP
rs919073390 1837 dbSNP
rs972033421 1840 dbSNP
rs567785543 1844 dbSNP
rs566284964 1854 dbSNP
rs17002190 1855 dbSNP
rs78265772 1858 dbSNP
rs971731305 1862 dbSNP
rs1348565487 1866 dbSNP
rs1199775726 1867 dbSNP
rs1184270715 1871 dbSNP
rs565133437 1871 dbSNP
rs1238952787 1882 dbSNP
rs5758097 1889 dbSNP
rs992169896 1891 dbSNP
rs547975476 1894 dbSNP
rs529611830 1896 dbSNP
rs112749715 1899 dbSNP
rs1172462862 1900 dbSNP
rs1399460024 1909 dbSNP
rs1411097128 1931 dbSNP
rs1331613832 1934 dbSNP
rs1357917307 1940 dbSNP
rs1000934216 1947 dbSNP
rs1444105793 1951 dbSNP
rs79763422 1954 dbSNP
rs1021554753 1962 dbSNP
rs900154088 1968 dbSNP
rs902095058 1968 dbSNP
rs900446214 1975 dbSNP
rs1342971192 1977 dbSNP
rs182316845 1981 dbSNP
rs1258784755 1985 dbSNP
rs1457525115 1989 dbSNP
rs1441749419 1997 dbSNP
rs531606599 2001 dbSNP
rs1008695435 2003 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-3
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796039. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796039
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-3 / 4-Thiouridine
Location of target site ENST00000216218.3 | 3UTR | UUGGCUUAACUCAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC -0.363 0.1 -0.266 0.18 14 Click to see details
STAD -0.605 0.1 -0.143 0.39 6 Click to see details
BRCA 0.5 0.1 0.214 0.31 8 Click to see details
PAAD -0.783 0.21 -1.000 0.5 3 Click to see details
HNSC 0.374 0.23 0.314 0.27 6 Click to see details
KIRP -0.384 0.26 -0.200 0.37 5 Click to see details
KIRC -0.139 0.37 -0.071 0.43 8 Click to see details
THCA 0.034 0.45 -0.187 0.26 14 Click to see details
LUSC -0.016 0.49 0.357 0.22 7 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
UCEC 0.002 0.5 -0.017 0.48 9 Click to see details
62 hsa-miR-2116-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080547 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT135054 ADSS adenylosuccinate synthase 2 4
MIRT147317 KPNA2 karyopherin subunit alpha 2 2 4
MIRT154323 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT326799 SYAP1 synapse associated protein 1 2 2
MIRT357963 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384296 GOLT1B golgi transport 1B 2 2
MIRT442316 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443785 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446868 NBPF3 NBPF member 3 2 2
MIRT447647 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448470 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449121 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450245 TRIM66 tripartite motif containing 66 2 2
MIRT450270 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450688 RPN2 ribophorin II 2 2
MIRT481123 AZIN1 antizyme inhibitor 1 2 4
MIRT497207 CDH7 cadherin 7 2 4
MIRT502956 CCNT2 cyclin T2 2 2
MIRT509226 KIF14 kinesin family member 14 2 6
MIRT515395 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525559 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525608 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533254 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535782 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535803 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT543211 TMEM117 transmembrane protein 117 2 2
MIRT552792 YAF2 YY1 associated factor 2 2 2
MIRT553947 STAMBP STAM binding protein 2 2
MIRT556217 MB21D2 Mab-21 domain containing 2 2 2
MIRT566351 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT568429 GDNF glial cell derived neurotrophic factor 2 2
MIRT568521 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT573359 PDE3A phosphodiesterase 3A 2 2
MIRT574653 LMAN2 lectin, mannose binding 2 2 2
MIRT608172 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610692 FAM89A family with sequence similarity 89 member A 2 2
MIRT618459 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT622281 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624615 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631041 TAS2R30 taste 2 receptor member 30 2 2
MIRT638335 RCAN1 regulator of calcineurin 1 2 2
MIRT641630 KIAA1244 ARFGEF family member 3 1 1
MIRT649117 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652246 TPI1 triosephosphate isomerase 1 2 2
MIRT659865 CAPRIN1 cell cycle associated protein 1 2 4
MIRT669219 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682585 CPA4 carboxypeptidase A4 2 2
MIRT690129 EPHX2 epoxide hydrolase 2 2 2
MIRT699793 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT699991 RPS24 ribosomal protein S24 2 2
MIRT710376 LMBR1 limb development membrane protein 1 2 2
MIRT710412 YTHDC1 YTH domain containing 1 2 2
MIRT710574 TNPO1 transportin 1 2 2
MIRT712045 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT713292 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT718211 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718809 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719341 VGLL4 vestigial like family member 4 2 2
MIRT720841 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT724076 NCKAP1L NCK associated protein 1 like 2 2
MIRT724602 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2116 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-2116-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2116-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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