miRTarBase - #MIRT444084


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pre-miRNA Information
pre-miRNA hsa-mir-660   
Genomic Coordinates chrX: 50013241 - 50013337
Synonyms MIRN660, hsa-mir-660, MIR660
Description Homo sapiens miR-660 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-660-3p
Sequence 52| ACCUCCUGUGUGCAUGGAUUA |72
Evidence Not_experimental
Experiments
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1221699333 1 dbSNP
rs781893004 6 dbSNP
rs180785970 8 dbSNP
rs1272406504 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol C12orf73   
Synonyms -
Description chromosome 12 open reading frame 73
Transcript NM_001135570   
Expression
Putative miRNA Targets on C12orf73
3'UTR of C12orf73
(miRNA target sites are highlighted)		 
>C12orf73|NM_001135570|3'UTR
   1 CTATGCCAAGAATTCTGTGAATAATATAAGTCTTAAATATGTATTTCTTAATTTATTGCATCAAACTACTTGTCCTTAAG
  81 CACTTAGTCTAATGCTAACTGCAAGAGGAGGTGCTCAGTGGATGTTTAGCCGATACGTTGAAATTTAATTACGGTTTGAT
 161 TGATATTTCTTGAAAACTGCCAAAGCACATATCATCAAACCATTTCATGAATATGGTTTGGAAGATGTTTAGTCTTGAAT
 241 ATAACGCGAAATAGAATATTTGTAAGTCTACTATATGGGTTGTCTTTATTTCATATAAATTAAGAAATTATTTAAAACTA
 321 TGAACTAGTTTCATTAATTGAATTTGCTAAGTGGAGTTATTTCTCATTGCTAAACTGTTTTTTTTCAAATTCTAGATCTC
 401 TGCTAACTTTAGTAAATGAACACTAAAGTGGTGAGCTTTGATAATGCATTTTGTGGATACAAAATCATCGCCTCATCACT
 481 TTCTAGAATGAAAGGCTGGGGGCATTGCTCACCTTTTGCGTGAAGAAAAGACCTGTCCCTTAGAGCCAGTTTTTGCTTAA
 561 GGGGAGGACAGACCGTCGTCACCCAGTGGACCACGTGAATGAATGGATGCAGTGCATGCTTTAGAAGCACCGCATACCTC
 641 CTTTTACAGGTACAGAGTAAGTGGTCTGGCTACTGAGGGAAAGAGTCATGATTTGAATCCGAGTCTTCTGTAAGACAATG
 721 ACTTCATGAAGGTGAAAAATCAGTTTTATGGTTATTAAAGTAAAAATTTACCTTGGGTAAAAATGCCATCTTTATTTCAT
 801 TAAGTACTGGTTCTAAGTGACTTCCAATAAGATACATTTTCTTCCTGTTTTGAAGTTGATCCCCATTGTGAAAAATATAC
 881 ATTGTAGTGGTCATGGAAATGCGCCATCCATACTCCCTAAGGCAGGCTTGTTGCCCTAGTATCAAGCATGCCAGCAGCTT
 961 TCAATGGTCAGCTTCTAGAAGGATTGCCTCGGCTATGGTGGCCTTGCTCAAAGCCATGCCTCCTGAAGGGGCCCAAATCC
1041 AGTGACTGTTGGAGGTGAGAATAGAAAGGCCTGGCCACTTCAGCACGTGAGTGGTGGGCAACTCTGCTGGGCCCACCACA
1121 ACTCCCTATGGGGTTTAGGGACACTGTCTTTGGATCTGCATTGCAACTCAACTTATACCTCTGCTCAGTCCTGTTTCCTT
1201 TCTCAGGTGTTGATCGAAGGGTGTGCCTTCATAGACCCCCTGCTAAACTGCACCTCAGTGTTTCTTGGAGAACCAAATCT
1281 GTAACATATATGCATTAAAAATTAAAGGCAGTACTATATTAAAAAAAAAACAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUA-GGU--ACGUGUGUCCUCCa 5'
            || |:|  |||| | |||||| 
Target 5' taATGCTAACTGCA-AGAGGAGGt 3'
 90 - 112 128.00 -15.20
2 
miRNA  3' auUAGGU-ACGUGUGUCCUCCa 5'
            ||||| ||  ::: ||||| 
Target 5' aaATCCAGTGACTGTTGGAGGt 3'
 1035 - 1056 115.00 -16.70
3 
miRNA  3' auUAGGUACGUG-UGUCCUCCa 5'
            :|:: ||| : | :||||| 
Target 5' caGTTTTTGCTTAAGGGGAGGa 3'
 547 - 568 107.00 -13.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31586242 15 COSMIC
COSN31566382 42 COSMIC
COSN31583520 47 COSMIC
COSN15305256 48 COSMIC
COSN31537326 121 COSMIC
COSN23013570 178 COSMIC
COSN28231238 212 COSMIC
COSN30510109 225 COSMIC
COSN5928592 439 COSMIC
COSN5928591 445 COSMIC
COSN8692564 619 COSMIC
COSN1555275 709 COSMIC
COSN5928590 903 COSMIC
COSN24337469 1107 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1343032418 4 dbSNP
rs1202245310 5 dbSNP
rs1471447374 7 dbSNP
rs1410969234 11 dbSNP
rs1334805410 12 dbSNP
rs1199951180 15 dbSNP
rs781108477 17 dbSNP
rs770689262 26 dbSNP
rs1230155028 27 dbSNP
rs781320052 27 dbSNP
rs901273786 30 dbSNP
rs2293625 35 dbSNP
rs960851713 37 dbSNP
rs781679747 40 dbSNP
rs557898030 41 dbSNP
rs1476792660 45 dbSNP
rs1234467141 47 dbSNP
rs11111854 48 dbSNP
rs1054039661 60 dbSNP
rs1456671717 61 dbSNP
rs1318385684 64 dbSNP
rs994247663 73 dbSNP
rs961738151 81 dbSNP
rs1390138558 82 dbSNP
rs935604246 83 dbSNP
rs146736172 90 dbSNP
rs1005932419 93 dbSNP
rs1323222494 97 dbSNP
rs1329533271 100 dbSNP
rs558695890 100 dbSNP
rs1275535875 101 dbSNP
rs1328525733 104 dbSNP
rs778904478 107 dbSNP
rs10247 118 dbSNP
rs1270511627 122 dbSNP
rs889713860 126 dbSNP
rs538801340 131 dbSNP
rs1389320567 132 dbSNP
rs1049670825 136 dbSNP
rs560729091 137 dbSNP
rs982295550 138 dbSNP
rs755227211 140 dbSNP
rs1471947389 145 dbSNP
rs1156928791 149 dbSNP
rs1251180703 150 dbSNP
rs949135293 152 dbSNP
rs143350869 153 dbSNP
rs963370191 159 dbSNP
rs1388772656 160 dbSNP
rs1129553 161 dbSNP
rs754068599 163 dbSNP
rs1349962601 164 dbSNP
rs983316666 170 dbSNP
rs15805 178 dbSNP
rs1202777743 183 dbSNP
rs1330384959 186 dbSNP
rs1341815373 188 dbSNP
rs1030100219 189 dbSNP
rs1358832872 201 dbSNP
rs1042730521 206 dbSNP
rs35637034 206 dbSNP
rs567489879 221 dbSNP
rs1290136348 243 dbSNP
rs1047490 245 dbSNP
rs916862609 246 dbSNP
rs190327234 247 dbSNP
rs991021302 248 dbSNP
rs960887294 251 dbSNP
rs186216021 254 dbSNP
rs1366500992 256 dbSNP
rs750920703 262 dbSNP
rs1164106991 270 dbSNP
rs1370176334 273 dbSNP
rs1427949170 276 dbSNP
rs961493125 282 dbSNP
rs1464412837 293 dbSNP
rs1294850310 298 dbSNP
rs1017395589 304 dbSNP
rs1369667369 312 dbSNP
rs1005591502 317 dbSNP
rs954020690 319 dbSNP
rs1311138214 320 dbSNP
rs1342700985 327 dbSNP
rs540519032 328 dbSNP
rs1028267266 360 dbSNP
rs1315359301 366 dbSNP
rs140800870 367 dbSNP
rs901061696 371 dbSNP
rs1202531254 372 dbSNP
rs1053816379 375 dbSNP
rs1480634365 376 dbSNP
rs1199817272 377 dbSNP
rs999760241 379 dbSNP
rs902781104 380 dbSNP
rs78351903 385 dbSNP
rs1433839686 386 dbSNP
rs1389832686 397 dbSNP
rs1447910921 410 dbSNP
rs1046524784 415 dbSNP
rs768161825 417 dbSNP
rs181211654 428 dbSNP
rs1175646142 435 dbSNP
rs1031515771 455 dbSNP
rs916792830 460 dbSNP
rs1404943045 465 dbSNP
rs2164747 465 dbSNP
rs188795658 466 dbSNP
rs763576782 470 dbSNP
rs1297356392 475 dbSNP
rs530421412 489 dbSNP
rs762652659 495 dbSNP
rs1043188680 508 dbSNP
rs1299284732 512 dbSNP
rs1231879918 514 dbSNP
rs1346237278 514 dbSNP
rs867089079 517 dbSNP
rs908861641 520 dbSNP
rs1484180147 527 dbSNP
rs948440083 530 dbSNP
rs561429998 538 dbSNP
rs1247190499 541 dbSNP
rs1463335635 561 dbSNP
rs879643077 565 dbSNP
rs544188537 566 dbSNP
rs1432716103 569 dbSNP
rs754509408 573 dbSNP
rs1349465995 574 dbSNP
rs939620377 575 dbSNP
rs183773215 577 dbSNP
rs3763996 578 dbSNP
rs1215391566 582 dbSNP
rs975903091 583 dbSNP
rs940181126 586 dbSNP
rs910003173 589 dbSNP
rs1385777131 593 dbSNP
rs1298581207 594 dbSNP
rs1313396844 601 dbSNP
rs1466502391 616 dbSNP
rs1224064591 617 dbSNP
rs1344499782 618 dbSNP
rs191458884 624 dbSNP
rs12227567 631 dbSNP
rs150954333 632 dbSNP
rs1252795444 638 dbSNP
rs1189655999 641 dbSNP
rs1269567093 653 dbSNP
rs1184689859 654 dbSNP
rs1028340787 662 dbSNP
rs1480771122 663 dbSNP
rs1484854909 670 dbSNP
rs976715287 677 dbSNP
rs1410395728 695 dbSNP
rs190191362 700 dbSNP
rs185763973 712 dbSNP
rs1032001239 716 dbSNP
rs1347792984 717 dbSNP
rs958132827 720 dbSNP
rs1291373817 723 dbSNP
rs1369182269 724 dbSNP
rs1032315150 726 dbSNP
rs556845722 731 dbSNP
rs902727251 738 dbSNP
rs1230102300 743 dbSNP
rs142514423 747 dbSNP
rs568890569 748 dbSNP
rs1021400144 754 dbSNP
rs1288583425 760 dbSNP
rs1219661410 766 dbSNP
rs1411284281 769 dbSNP
rs1012639561 772 dbSNP
rs1181510038 778 dbSNP
rs1338425709 782 dbSNP
rs1333290051 788 dbSNP
rs1473869081 804 dbSNP
rs894202505 807 dbSNP
rs1413529496 818 dbSNP
rs1403945009 819 dbSNP
rs1013870799 820 dbSNP
rs1396429220 821 dbSNP
rs1424805818 827 dbSNP
rs552188265 835 dbSNP
rs1404237002 844 dbSNP
rs1156927389 845 dbSNP
rs192829236 865 dbSNP
rs34516920 865 dbSNP
rs1055320051 866 dbSNP
rs941757893 873 dbSNP
rs1412797743 877 dbSNP
rs1226395814 882 dbSNP
rs1315153652 885 dbSNP
rs367994154 888 dbSNP
rs1161565672 889 dbSNP
rs1360406502 893 dbSNP
rs1471944290 897 dbSNP
rs148396094 899 dbSNP
rs1368213408 902 dbSNP
rs1305080045 903 dbSNP
rs938310843 923 dbSNP
rs906833313 931 dbSNP
rs376087571 935 dbSNP
rs1037682968 938 dbSNP
rs1444545516 939 dbSNP
rs2248995 940 dbSNP
rs1386200888 945 dbSNP
rs1047353101 948 dbSNP
rs928978872 953 dbSNP
rs768634901 970 dbSNP
rs1329535779 982 dbSNP
rs776989467 982 dbSNP
rs910058324 985 dbSNP
rs1268229245 988 dbSNP
rs1229799912 990 dbSNP
rs372434520 991 dbSNP
rs932730395 1009 dbSNP
rs921309737 1016 dbSNP
rs1344495881 1025 dbSNP
rs1283285206 1032 dbSNP
rs775715671 1039 dbSNP
rs749461304 1041 dbSNP
rs868333928 1046 dbSNP
rs1031615641 1062 dbSNP
rs977722522 1069 dbSNP
rs958075405 1076 dbSNP
rs1476130856 1081 dbSNP
rs1167967203 1082 dbSNP
rs1032429854 1084 dbSNP
rs1318378062 1085 dbSNP
rs10861149 1086 dbSNP
rs551316242 1087 dbSNP
rs1322676467 1094 dbSNP
rs759646902 1096 dbSNP
rs1434086948 1104 dbSNP
rs756497854 1106 dbSNP
rs2722190 1107 dbSNP
rs1431692538 1112 dbSNP
rs1014234203 1114 dbSNP
rs895416292 1117 dbSNP
rs1391590718 1120 dbSNP
rs1034232292 1121 dbSNP
rs1264292805 1124 dbSNP
rs958453882 1128 dbSNP
rs1207180674 1138 dbSNP
rs1035399673 1140 dbSNP
rs1448388716 1142 dbSNP
rs1193401930 1144 dbSNP
rs1002527918 1145 dbSNP
rs897472446 1146 dbSNP
rs1047469091 1167 dbSNP
rs188596679 1168 dbSNP
rs1456554124 1171 dbSNP
rs1156713205 1174 dbSNP
rs545060227 1176 dbSNP
rs888670273 1182 dbSNP
rs1401513879 1184 dbSNP
rs1323080169 1185 dbSNP
rs1329479090 1186 dbSNP
rs1450663680 1189 dbSNP
rs200809647 1191 dbSNP
rs1210835836 1206 dbSNP
rs34334666 1207 dbSNP
rs755438421 1207 dbSNP
rs1262899025 1212 dbSNP
rs1351766728 1212 dbSNP
rs1048597104 1214 dbSNP
rs932800821 1215 dbSNP
rs143373921 1219 dbSNP
rs921381170 1222 dbSNP
rs182979933 1227 dbSNP
rs1210066880 1232 dbSNP
rs559185865 1239 dbSNP
rs1179846463 1248 dbSNP
rs944041293 1249 dbSNP
rs1358126883 1251 dbSNP
rs943257310 1258 dbSNP
rs374547285 1264 dbSNP
rs977422033 1266 dbSNP
rs1388806668 1287 dbSNP
rs1303857061 1288 dbSNP
rs752062168 1289 dbSNP
rs1227519200 1298 dbSNP
rs1408542160 1309 dbSNP
rs1365796519 1314 dbSNP
rs573768717 1320 dbSNP
rs1244509728 1323 dbSNP
rs1434386718 1325 dbSNP
rs1356854643 1328 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000547975.1 | 3UTR | ucaaguuucucaacag
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000547975.1 | 3UTR | ucaaguuucucaacag
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
348 hsa-miR-660-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059151 TXNIP thioredoxin interacting protein 2 2
MIRT294324 ZNF264 zinc finger protein 264 2 2
MIRT306043 SKIL SKI like proto-oncogene 2 4
MIRT392841 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT444084 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT458774 CES2 carboxylesterase 2 2 2
MIRT460273 SLC26A2 solute carrier family 26 member 2 2 2
MIRT462675 HMOX1 heme oxygenase 1 2 4
MIRT473711 MAPK1 mitogen-activated protein kinase 1 2 6
MIRT478539 CTNS cystinosin, lysosomal cystine transporter 2 2
MIRT483234 FAM13C family with sequence similarity 13 member C 2 4
MIRT486255 BCORL1 BCL6 corepressor like 1 2 2
MIRT501951 MAT2A methionine adenosyltransferase 2A 2 10
MIRT513043 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513249 FBXO17 F-box protein 17 2 2
MIRT526940 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT528176 C6orf47 chromosome 6 open reading frame 47 2 2
MIRT531525 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT532746 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT534241 SLC23A1 solute carrier family 23 member 1 2 2
MIRT538198 DBN1 drebrin 1 2 2
MIRT539305 AMOTL1 angiomotin like 1 2 2
MIRT539567 CNKSR3 CNKSR family member 3 2 4
MIRT540043 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT540232 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT540251 RGS17 regulator of G protein signaling 17 2 2
MIRT540878 ZBTB24 zinc finger and BTB domain containing 24 2 2
MIRT543484 RXRA retinoid X receptor alpha 2 2
MIRT551435 F2 coagulation factor II, thrombin 2 2
MIRT553925 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT556312 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556943 ING1 inhibitor of growth family member 1 2 2
MIRT569883 EFEMP2 EGF containing fibulin like extracellular matrix protein 2 2 2
MIRT571849 NRBF2 nuclear receptor binding factor 2 2 2
MIRT572420 VWA5A von Willebrand factor A domain containing 5A 2 2
MIRT572495 BTN2A2 butyrophilin subfamily 2 member A2 2 2
MIRT572564 AFF1 AF4/FMR2 family member 1 2 2
MIRT572883 CHST15 carbohydrate sulfotransferase 15 2 2
MIRT574988 Slc38a5 solute carrier family 38, member 5 2 4
MIRT575264 Timp3 tissue inhibitor of metalloproteinase 3 2 2
MIRT608476 RRP36 ribosomal RNA processing 36 2 4
MIRT608529 TMOD3 tropomodulin 3 2 2
MIRT608578 RNF149 ring finger protein 149 2 2
MIRT608615 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 2
MIRT608679 STPG1 sperm tail PG-rich repeat containing 1 2 2
MIRT608727 ZKSCAN1 zinc finger with KRAB and SCAN domains 1 2 2
MIRT609575 CATSPER4 cation channel sperm associated 4 2 2
MIRT609710 TMEM132C transmembrane protein 132C 2 2
MIRT609858 DAZAP2 DAZ associated protein 2 2 2
MIRT610262 LRRC47 leucine rich repeat containing 47 2 2
MIRT610349 AGTRAP angiotensin II receptor associated protein 2 2
MIRT610729 PEA15 phosphoprotein enriched in astrocytes 15 2 4
MIRT610803 KLK2 kallikrein related peptidase 2 2 2
MIRT610968 MAFK MAF bZIP transcription factor K 2 2
MIRT611117 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 2
MIRT611600 JAKMIP3 Janus kinase and microtubule interacting protein 3 2 4
MIRT612211 TMEM109 transmembrane protein 109 2 2
MIRT612248 MICALL1 MICAL like 1 2 2
MIRT613252 CAV1 caveolin 1 2 4
MIRT613323 ARID3A AT-rich interaction domain 3A 2 4
MIRT613514 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT613605 TP53 tumor protein p53 2 2
MIRT613632 ARHGAP35 Rho GTPase activating protein 35 2 2
MIRT613809 ATP6AP1L ATPase H+ transporting accessory protein 1 like 2 2
MIRT614835 PRKCA protein kinase C alpha 2 2
MIRT614985 GIPC1 GIPC PDZ domain containing family member 1 2 2
MIRT615320 MLXIPL MLX interacting protein like 2 2
MIRT615504 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT615529 SPANXN5 SPANX family member N5 2 2
MIRT615610 SPANXN1 SPANX family member N1 2 2
MIRT615755 C6 complement C6 2 2
MIRT615952 SORD sorbitol dehydrogenase 2 2
MIRT616284 HMGB1 high mobility group box 1 2 2
MIRT616626 KCNJ11 potassium voltage-gated channel subfamily J member 11 2 4
MIRT616882 DGCR14 ess-2 splicing factor homolog 2 2
MIRT616994 COL19A1 collagen type XIX alpha 1 chain 2 2
MIRT617080 SPIB Spi-B transcription factor 2 2
MIRT617345 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT617712 RUSC2 RUN and SH3 domain containing 2 2 2
MIRT618102 PPP5D1 PPP5 tetratricopeptide repeat domain containing 1 2 2
MIRT618493 DENND5B DENN domain containing 5B 2 4
MIRT618756 SLC38A5 solute carrier family 38 member 5 2 5
MIRT619928 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT620028 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620087 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 2
MIRT620209 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620557 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620770 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT620784 IL10RB interleukin 10 receptor subunit beta 2 2
MIRT620895 ANO7 anoctamin 7 2 2
MIRT621284 PIWIL1 piwi like RNA-mediated gene silencing 1 2 2
MIRT622594 PRRG4 proline rich and Gla domain 4 2 2
MIRT623273 MED28 mediator complex subunit 28 2 2
MIRT624247 VSIG2 V-set and immunoglobulin domain containing 2 2 2
MIRT624298 COMMD2 COMM domain containing 2 2 2
MIRT624526 C3orf62 chromosome 3 open reading frame 62 2 2
MIRT624567 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT624692 AR androgen receptor 2 2
MIRT624767 AKR1D1 aldo-keto reductase family 1 member D1 2 2
MIRT624829 ACO1 aconitase 1 2 2
MIRT625159 ZCCHC8 zinc finger CCHC-type containing 8 2 4
MIRT625261 ZNF566 zinc finger protein 566 2 2
MIRT625388 ZNF716 zinc finger protein 716 2 2
MIRT625827 FBXO42 F-box protein 42 2 2
MIRT625837 NXPE2 neurexophilin and PC-esterase domain family member 2 2 2
MIRT626021 XRCC2 X-ray repair cross complementing 2 2 2
MIRT626052 PDE4C phosphodiesterase 4C 2 2
MIRT626354 PACS1 phosphofurin acidic cluster sorting protein 1 2 2
MIRT626778 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 2
MIRT627050 HOXA13 homeobox A13 2 2
MIRT627274 XIAP X-linked inhibitor of apoptosis 2 2
MIRT627310 WDR31 WD repeat domain 31 2 2
MIRT627916 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT630557 CCDC107 coiled-coil domain containing 107 2 2
MIRT630775 MSANTD3 Myb/SANT DNA binding domain containing 3 2 2
MIRT632083 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT633138 C6orf132 chromosome 6 open reading frame 132 2 2
MIRT633711 PEX26 peroxisomal biogenesis factor 26 2 4
MIRT634361 RNF157 ring finger protein 157 2 2
MIRT635739 IFNAR1 interferon alpha and beta receptor subunit 1 2 2
MIRT636963 APTX aprataxin 2 2
MIRT637373 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT637815 GGPS1 geranylgeranyl diphosphate synthase 1 2 2
MIRT637911 FAM153B family with sequence similarity 153 member B 2 2
MIRT638474 PANK3 pantothenate kinase 3 2 2
MIRT638633 GSR glutathione-disulfide reductase 2 4
MIRT639493 TSPAN1 tetraspanin 1 2 2
MIRT639773 GPR45 G protein-coupled receptor 45 2 2
MIRT639781 RAX retina and anterior neural fold homeobox 2 2
MIRT639915 SLIT1 slit guidance ligand 1 2 2
MIRT640055 MCL1 MCL1, BCL2 family apoptosis regulator 2 4
MIRT640108 DUOX2 dual oxidase 2 2 2
MIRT640402 ZNF785 zinc finger protein 785 2 2
MIRT640555 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT640751 ZBTB26 zinc finger and BTB domain containing 26 2 2
MIRT640765 GLO1 glyoxalase I 2 2
MIRT640915 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641521 CREBBP CREB binding protein 2 2
MIRT641533 SNW1 SNW domain containing 1 2 2
MIRT641692 SPCS1 signal peptidase complex subunit 1 2 2
MIRT641745 MACROD2 MACRO domain containing 2 2 2
MIRT641866 STOML1 stomatin like 1 2 2
MIRT641951 RNF115 ring finger protein 115 2 2
MIRT642205 SMAGP small cell adhesion glycoprotein 2 2
MIRT642420 CILP2 cartilage intermediate layer protein 2 2 2
MIRT643028 LETM2 leucine zipper and EF-hand containing transmembrane protein 2 2 2
MIRT643406 PAX1 paired box 1 2 2
MIRT643500 ZNF195 zinc finger protein 195 2 2
MIRT643754 LEFTY2 left-right determination factor 2 2 2
MIRT643898 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT644036 CENPM centromere protein M 2 2
MIRT644200 LAT2 linker for activation of T-cells family member 2 2 2
MIRT644228 ADD1 adducin 1 2 2
MIRT644690 GPR55 G protein-coupled receptor 55 2 2
MIRT645128 HES2 hes family bHLH transcription factor 2 2 2
MIRT645347 AGTPBP1 ATP/GTP binding protein 1 2 2
MIRT645897 ATP2B3 ATPase plasma membrane Ca2+ transporting 3 2 2
MIRT645905 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT646049 NPR1 natriuretic peptide receptor 1 2 2
MIRT646137 C1orf147 chromosome 1 open reading frame 147 2 2
MIRT646219 DUSP10 dual specificity phosphatase 10 2 2
MIRT646385 SLC22A6 solute carrier family 22 member 6 2 2
MIRT646739 FADS1 fatty acid desaturase 1 2 2
MIRT646877 NT5C2 5'-nucleotidase, cytosolic II 2 2
MIRT647109 GNL3L G protein nucleolar 3 like 2 2
MIRT647523 PPIE peptidylprolyl isomerase E 2 2
MIRT647553 CYP2B6 cytochrome P450 family 2 subfamily B member 6 2 2
MIRT647755 NBPF3 NBPF member 3 2 2
MIRT648075 ZMIZ2 zinc finger MIZ-type containing 2 2 2
MIRT648225 TM4SF20 transmembrane 4 L six family member 20 2 2
MIRT648441 MYOZ3 myozenin 3 2 2
MIRT648823 ZNF689 zinc finger protein 689 2 2
MIRT649229 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT649237 FEM1A fem-1 homolog A 2 2
MIRT649249 TRIM65 tripartite motif containing 65 2 2
MIRT649459 WDR70 WD repeat domain 70 2 2
MIRT649637 RASA4 RAS p21 protein activator 4 2 2
MIRT650745 FKTN fukutin 2 2
MIRT651041 ZNF652 zinc finger protein 652 2 2
MIRT651754 VEGFA vascular endothelial growth factor A 2 2
MIRT651799 UST uronyl 2-sulfotransferase 2 2
MIRT652562 TLX1 T-cell leukemia homeobox 1 2 2
MIRT652776 TENM3 teneurin transmembrane protein 3 2 2
MIRT652939 SYNGR1 synaptogyrin 1 2 2
MIRT653006 STXBP5L syntaxin binding protein 5 like 2 2
MIRT653030 STX1B syntaxin 1B 2 2
MIRT653279 SNAP29 synaptosome associated protein 29 2 2
MIRT654057 S1PR1 sphingosine-1-phosphate receptor 1 2 2
MIRT654329 RBM33 RNA binding motif protein 33 2 2
MIRT654650 PTAFR platelet activating factor receptor 2 2
MIRT656577 LSM10 LSM10, U7 small nuclear RNA associated 2 2
MIRT656595 LSAMP limbic system-associated membrane protein 2 2
MIRT656646 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT656739 LMBR1L limb development membrane protein 1 like 2 2
MIRT656903 KIAA1958 KIAA1958 2 2
MIRT657392 HM13 histocompatibility minor 13 2 2
MIRT657528 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT657611 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT657668 GPR26 G protein-coupled receptor 26 2 2
MIRT657689 GPR155 G protein-coupled receptor 155 2 2
MIRT657818 GJD3 gap junction protein delta 3 2 2
MIRT658410 FAM208A family with sequence similarity 208 member A 2 2
MIRT658955 DNMT3A DNA methyltransferase 3 alpha 2 2
MIRT659425 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT659499 CISD3 CDGSH iron sulfur domain 3 2 2
MIRT659994 C2CD2L C2CD2 like 2 2
MIRT660215 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT660493 ARRDC3 arrestin domain containing 3 2 2
MIRT660761 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660827 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT661576 EPHX2 epoxide hydrolase 2 2 2
MIRT661711 MTO1 mitochondrial tRNA translation optimization 1 2 4
MIRT661826 PRPSAP1 phosphoribosyl pyrophosphate synthetase associated protein 1 2 2
MIRT662123 APOL6 apolipoprotein L6 2 2
MIRT662254 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT662314 ADM2 adrenomedullin 2 2 2
MIRT662341 MYLK3 myosin light chain kinase 3 2 2
MIRT662453 SEMA5A semaphorin 5A 2 2
MIRT662746 LRRC3C leucine rich repeat containing 3C 2 2
MIRT662901 GJB1 gap junction protein beta 1 2 2
MIRT663018 KIAA1586 KIAA1586 2 2
MIRT663102 THEM4 thioesterase superfamily member 4 2 2
MIRT663574 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT664125 C4orf32 family with sequence similarity 241 member A 2 2
MIRT664560 SORBS2 sorbin and SH3 domain containing 2 2 2
MIRT665589 TUBD1 tubulin delta 1 2 2
MIRT666464 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT666527 RNF170 ring finger protein 170 2 2
MIRT666874 POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) 2 2
MIRT667055 PARVA parvin alpha 2 2
MIRT667282 NAV1 neuron navigator 1 2 2
MIRT667928 IGLON5 IgLON family member 5 2 2
MIRT667957 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 2
MIRT668336 FKBP5 FK506 binding protein 5 2 2
MIRT668718 DIP2C disco interacting protein 2 homolog C 2 2
MIRT669310 C17orf75 chromosome 17 open reading frame 75 2 2
MIRT669688 ABLIM1 actin binding LIM protein 1 2 2
MIRT671524 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 2
MIRT672112 TLCD2 TLC domain containing 2 2 4
MIRT672186 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT672702 ZNF677 zinc finger protein 677 2 2
MIRT673473 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT673617 HPSE heparanase 2 2
MIRT673763 ZNF333 zinc finger protein 333 2 2
MIRT674817 FAM229B family with sequence similarity 229 member B 2 2
MIRT675304 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT675404 SVOP SV2 related protein 2 2
MIRT676163 OGFOD1 2-oxoglutarate and iron dependent oxygenase domain containing 1 2 2
MIRT676320 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT676347 PCCB propionyl-CoA carboxylase beta subunit 2 2
MIRT676526 RNF216 ring finger protein 216 2 2
MIRT676571 VSIG1 V-set and immunoglobulin domain containing 1 2 2
MIRT676588 RDH13 retinol dehydrogenase 13 2 2
MIRT676648 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT676723 METTL14 methyltransferase like 14 2 2
MIRT676805 RILPL1 Rab interacting lysosomal protein like 1 2 2
MIRT676813 SHROOM4 shroom family member 4 2 2
MIRT677204 MURC caveolae associated protein 4 2 2
MIRT677284 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT677359 POC1A POC1 centriolar protein A 2 2
MIRT677516 SLC10A6 solute carrier family 10 member 6 2 2
MIRT677530 OCIAD2 OCIA domain containing 2 2 2
MIRT677627 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 2
MIRT677669 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT678056 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT678132 METTL21A methyltransferase like 21A 2 2
MIRT678154 SLC4A4 solute carrier family 4 member 4 2 2
MIRT678463 GLYAT glycine-N-acyltransferase 2 2
MIRT678614 MRPL17 mitochondrial ribosomal protein L17 2 2
MIRT678716 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT679161 ZDHHC15 zinc finger DHHC-type containing 15 2 2
MIRT679307 SSBP2 single stranded DNA binding protein 2 2 2
MIRT679430 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT679499 ZNF106 zinc finger protein 106 2 2
MIRT679963 VTA1 vesicle trafficking 1 2 2
MIRT679983 E2F2 E2F transcription factor 2 2 2
MIRT680153 TOP3A DNA topoisomerase III alpha 2 2
MIRT680304 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT680330 LRRC58 leucine rich repeat containing 58 2 2
MIRT680401 OXA1L OXA1L, mitochondrial inner membrane protein 2 2
MIRT683911 PSMB9 proteasome subunit beta 9 2 2
MIRT684183 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT684238 C20orf144 chromosome 20 open reading frame 144 2 2
MIRT684284 CDK9 cyclin dependent kinase 9 2 2
MIRT685411 C1orf158 chromosome 1 open reading frame 158 2 2
MIRT686260 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT688250 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT688327 FAM151B family with sequence similarity 151 member B 2 2
MIRT688747 CNDP1 carnosine dipeptidase 1 2 2
MIRT689040 ANGPTL3 angiopoietin like 3 2 2
MIRT692525 PARD3 par-3 family cell polarity regulator 2 2
MIRT692984 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT699866 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT699877 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT700840 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT701538 NCKAP1 NCK associated protein 1 2 2
MIRT703683 FAM189B family with sequence similarity 189 member B 2 2
MIRT708555 SPA17 sperm autoantigenic protein 17 2 2
MIRT708579 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT708721 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT708984 CABP4 calcium binding protein 4 2 2
MIRT709195 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709679 PCDH17 protocadherin 17 2 2
MIRT709962 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT710173 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT710329 STK40 serine/threonine kinase 40 2 2
MIRT710532 TMEM201 transmembrane protein 201 2 2
MIRT710628 ASB7 ankyrin repeat and SOCS box containing 7 2 2
MIRT711037 RNF187 ring finger protein 187 2 2
MIRT711227 RETSAT retinol saturase 2 2
MIRT711418 RAB3C RAB3C, member RAS oncogene family 2 2
MIRT711469 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT711636 PEBP1 phosphatidylethanolamine binding protein 1 2 2
MIRT711658 RAB21 RAB21, member RAS oncogene family 2 2
MIRT711704 GMPR guanosine monophosphate reductase 2 2
MIRT711924 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT712061 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT712094 TMEM218 transmembrane protein 218 2 2
MIRT712541 CYB561D1 cytochrome b561 family member D1 2 2
MIRT714480 TBL2 transducin beta like 2 2 2
MIRT716323 SIGLEC10 sialic acid binding Ig like lectin 10 2 2
MIRT716750 C19orf24 chromosome 19 open reading frame 24 2 2
MIRT717014 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT717162 SHB SH2 domain containing adaptor protein B 2 2
MIRT717369 EDN2 endothelin 2 2 2
MIRT717481 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT718080 CLIC5 chloride intracellular channel 5 2 2
MIRT718545 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT718835 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT718864 LRSAM1 leucine rich repeat and sterile alpha motif containing 1 2 2
MIRT719149 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719687 ALDH1L2 aldehyde dehydrogenase 1 family member L2 2 2
MIRT719780 ZNF236 zinc finger protein 236 2 2
MIRT719859 KLF2 Kruppel like factor 2 2 2
MIRT720496 TMEM178B transmembrane protein 178B 2 2
MIRT720804 NUDT5 nudix hydrolase 5 2 2
MIRT720944 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2
MIRT721344 LIF LIF, interleukin 6 family cytokine 2 2
MIRT721805 GRM1 glutamate metabotropic receptor 1 2 2
MIRT721924 LINGO2 leucine rich repeat and Ig domain containing 2 2 2
MIRT722429 HRNR hornerin 2 2
MIRT723971 GPR146 G protein-coupled receptor 146 2 2
MIRT724225 ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 2 2
MIRT724272 HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 2 2
MIRT724659 PXDN peroxidasin 2 2
MIRT725282 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
MIRT725434 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT725604 CAPN6 calpain 6 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-660 4-hydroxynonenal NULL 5283344 Microarray human leukemic HL-60 cell 19022373 2009 up-regulated
miR-660 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-660 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-660 Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-660 Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-mir-660 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-mir-660 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-660 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-660 Cisplatin 5460033 NSC119875 approved resistant cell line (KYSE)
hsa-mir-660 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-660 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-660 Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-660-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-660-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-660-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-660-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-660-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-660-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-660-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)

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