miRTarBase - #MIRT445241


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol FOXD4   
Synonyms FKHL9, FOXD4A, FREAC-5, FREAC5
Description forkhead box D4
Transcript NM_207305   
Expression
Putative miRNA Targets on FOXD4
3'UTR of FOXD4
(miRNA target sites are highlighted)		 
>FOXD4|NM_207305|3'UTR
   1 AGCCAGGTGGGAGTGGGGAGCGACCCGCAGCTGCTCACTCCACCTTGCGCGGCCCATACTGGGCGTGTGCATCTGAATCC
  81 CGCTGGAGAGCAAACACGAACTTCTGTTCCCTGCAAAATGGTTAGAAAGAAACAGCTGGATTACGTTCCTCTAAAAACCA
 161 CCTGAACGTAACCTTCGCAGGGCGTCAAGTCATCTTTTCTTGCCTTCGGTTGTGGCTTCTGTGGCTTTCCCGATTTGCAC
 241 ATGTCCTGGGGTACTATGAACGTGAGTGGGGTATTTTGTTCTGGCATTAAAAGAAAAACAAGCAAGCAAACAAAAACACA
 321 GCCTCCGATGCCAAACATGTTCCCCCTTCTTCACTTCCTTGGAACTGGAAGTATTATTCCTAAGTCTAGTGCAAAATGCT
 401 TCTACTCTCTGTGTCTTCCTGATAGGGATGTTTAATGTAAGTAGGATATTAATTTCAGAACATTGATTTCTTATCTGTGT
 481 GTCTGACGTGCCATCTTTAATGTTAAAATTAAGGTGTTAAAATTAAGCCTAGTTATATAGACGAAATAAAATGCTAAGTC
 561 ACTACACTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauuUAGAGUAUCACGGAAGa 5'
               ||||: |  ||||||| 
Target 5' aagtcATCTTTTCTTGCCTTCg 3'
 187 - 208 157.00 -11.80
2 
miRNA  3' agaUUUA-GAGUAU------CACGGAAGa 5'
             |||| ||: ||      |||:|||| 
Target 5' gcaAAATGCTTCTACTCTCTGTGTCTTCc 3'
 391 - 419 141.00 -15.10
3 
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            |: :||| |  ||||| || 
Target 5' tgTGTGTCTGA-CGTGCCATCt 3'
 476 - 496 123.00 -10.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM7624017 21 COSMIC
COSM6666158 22 COSMIC
COSM7955408 26 COSMIC
COSM6245097 61 COSMIC
COSM8051549 62 COSMIC
COSM8946913 64 COSMIC
COSM8671706 65 COSMIC
COSM7919730 79 COSMIC
COSM6666167 80 COSMIC
COSM1252683 82 COSMIC
COSM8981725 129 COSMIC
COSM8962828 144 COSMIC
COSM7552619 145 COSMIC
COSM7947274 146 COSMIC
COSM8869083 163 COSMIC
COSN30111894 168 COSMIC
COSN31578551 177 COSMIC
COSN30133604 183 COSMIC
COSN31571230 198 COSMIC
COSN2306479 210 COSMIC
COSN17967342 243 COSMIC
COSN30129422 245 COSMIC
COSN20289684 290 COSMIC
COSN1372200 302 COSMIC
COSN30526657 349 COSMIC
COSN24421443 373 COSMIC
COSN31527920 407 COSMIC
COSN31479817 421 COSMIC
COSN31516807 470 COSMIC
COSN28630171 475 COSMIC
COSN31485271 492 COSMIC
COSN30124772 495 COSMIC
COSN31585051 496 COSMIC
COSN4943745 517 COSMIC
COSN30129053 520 COSMIC
COSN30131491 565 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1278497097 6 dbSNP
rs761155069 7 dbSNP
rs1368025670 10 dbSNP
rs773542998 11 dbSNP
rs767889814 13 dbSNP
rs1239288815 15 dbSNP
rs762155478 21 dbSNP
rs1467431425 22 dbSNP
rs1183575747 24 dbSNP
rs1213252672 25 dbSNP
rs763945169 26 dbSNP
rs373774813 27 dbSNP
rs778371272 27 dbSNP
rs759328745 28 dbSNP
rs776697268 33 dbSNP
rs1168618476 34 dbSNP
rs1363363989 36 dbSNP
rs770619651 37 dbSNP
rs1249891698 38 dbSNP
rs1191655692 39 dbSNP
rs746871961 40 dbSNP
rs1415332985 43 dbSNP
rs564118426 44 dbSNP
rs747810366 48 dbSNP
rs778327499 50 dbSNP
rs1165651788 52 dbSNP
rs546026483 53 dbSNP
rs1026899361 54 dbSNP
rs184811440 56 dbSNP
rs1290783277 59 dbSNP
rs1333383740 61 dbSNP
rs1244488977 63 dbSNP
rs563610552 65 dbSNP
rs1266461216 66 dbSNP
rs994907071 68 dbSNP
rs879085107 79 dbSNP
rs1665334 81 dbSNP
rs1194299809 82 dbSNP
rs1249837045 86 dbSNP
rs1483437105 88 dbSNP
rs1184205922 93 dbSNP
rs1255282075 97 dbSNP
rs1474869842 98 dbSNP
rs1485992745 104 dbSNP
rs1370044913 108 dbSNP
rs2441581 110 dbSNP
rs1245708742 112 dbSNP
rs1166982993 113 dbSNP
rs1370589068 117 dbSNP
rs781499748 123 dbSNP
rs1310592896 129 dbSNP
rs1354099867 144 dbSNP
rs1337486163 145 dbSNP
rs542213756 151 dbSNP
rs1323891809 157 dbSNP
rs574910328 159 dbSNP
rs1466324920 161 dbSNP
rs1218613810 162 dbSNP
rs1207359723 163 dbSNP
rs559817243 167 dbSNP
rs1182383830 168 dbSNP
rs1257948450 169 dbSNP
rs1297859560 172 dbSNP
rs1192248825 173 dbSNP
rs1215172825 174 dbSNP
rs1431310691 177 dbSNP
rs541524788 178 dbSNP
rs1033672096 179 dbSNP
rs1465927914 183 dbSNP
rs1303956166 188 dbSNP
rs1381748063 190 dbSNP
rs1380855595 193 dbSNP
rs1002229110 194 dbSNP
rs1396464629 203 dbSNP
rs1326311019 208 dbSNP
rs577313264 209 dbSNP
rs1359988970 210 dbSNP
rs1311697337 216 dbSNP
rs761534300 217 dbSNP
rs558835286 219 dbSNP
rs2441580 221 dbSNP
rs970739424 224 dbSNP
rs1257655723 225 dbSNP
rs2441579 227 dbSNP
rs1465066024 229 dbSNP
rs2441578 231 dbSNP
rs1207861169 239 dbSNP
rs1867912 243 dbSNP
rs1450875015 246 dbSNP
rs1191374821 252 dbSNP
rs1423794760 254 dbSNP
rs1171921308 257 dbSNP
rs1177656274 259 dbSNP
rs576626079 261 dbSNP
rs1320304715 262 dbSNP
rs906444848 267 dbSNP
rs1389851441 269 dbSNP
rs1428654122 270 dbSNP
rs1024975411 272 dbSNP
rs1423845829 278 dbSNP
rs554864655 284 dbSNP
rs536577064 285 dbSNP
rs892276820 286 dbSNP
rs1254041621 290 dbSNP
rs567703051 291 dbSNP
rs1208035369 295 dbSNP
rs1479948551 301 dbSNP
rs1211394706 303 dbSNP
rs1245739647 303 dbSNP
rs1488631562 318 dbSNP
rs1192417613 324 dbSNP
rs1405253774 325 dbSNP
rs747200494 327 dbSNP
rs1228781721 337 dbSNP
rs1459122665 338 dbSNP
rs1311748436 339 dbSNP
rs1437535840 340 dbSNP
rs1295296509 343 dbSNP
rs1301300562 344 dbSNP
rs1288944847 345 dbSNP
rs1236831929 347 dbSNP
rs1371940595 354 dbSNP
rs1303881089 357 dbSNP
rs1445688198 359 dbSNP
rs1223323904 361 dbSNP
rs1057585 364 dbSNP
rs1394047630 371 dbSNP
rs865822933 373 dbSNP
rs1482457670 374 dbSNP
rs1182316881 379 dbSNP
rs1462404995 380 dbSNP
rs1358119730 383 dbSNP
rs1161820267 387 dbSNP
rs1406110208 388 dbSNP
rs1167202591 397 dbSNP
rs1171144402 399 dbSNP
rs1409252058 401 dbSNP
rs1308766453 404 dbSNP
rs1352242747 405 dbSNP
rs1283317586 411 dbSNP
rs1356806918 412 dbSNP
rs1229631169 415 dbSNP
rs1270490086 421 dbSNP
rs1455333090 423 dbSNP
rs1395241805 425 dbSNP
rs1178425459 426 dbSNP
rs1417765238 427 dbSNP
rs1484282430 442 dbSNP
rs1186064067 443 dbSNP
rs546231043 445 dbSNP
rs1473348106 451 dbSNP
rs534417886 452 dbSNP
rs1196930210 454 dbSNP
rs1483198190 461 dbSNP
rs1278316980 462 dbSNP
rs1054042449 468 dbSNP
rs1333456491 475 dbSNP
rs1348881171 476 dbSNP
rs570533249 477 dbSNP
rs1665333 482 dbSNP
rs1449923568 488 dbSNP
rs1295199202 492 dbSNP
rs1364001554 497 dbSNP
rs1237144565 511 dbSNP
rs1228684447 514 dbSNP
rs1299103267 524 dbSNP
rs1333806155 528 dbSNP
rs1345145160 528 dbSNP
rs1308851727 533 dbSNP
rs1391915559 537 dbSNP
rs1212669672 538 dbSNP
rs1246648185 539 dbSNP
rs1354695010 542 dbSNP
rs1392050847 548 dbSNP
rs1477101949 553 dbSNP
rs936422429 554 dbSNP
rs1416166334 558 dbSNP
rs1435980103 560 dbSNP
rs1387649470 563 dbSNP
rs1375508480 566 dbSNP
rs1322169781 567 dbSNP
rs1329035053 569 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000382500.2 | 3UTR | UCAAGUCAUCUUUUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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