pre-miRNA Information | |
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pre-miRNA | hsa-mir-3915 |
Genomic Coordinates | chrX: 32583656 - 32583752 |
Description | Homo sapiens miR-3915 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | ||||||||||||||||
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Mature miRNA | hsa-miR-3915 | |||||||||||||||
Sequence | 21| UUGAGGAAAAGAUGGUCUUAUU |42 | |||||||||||||||
Evidence | Experimental | |||||||||||||||
Experiments | Illumina | |||||||||||||||
SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TCEANC | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | transcription elongation factor A N-terminal and central domain containing | ||||||||||||||||||||
Transcript | NM_152634 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TCEANC | |||||||||||||||||||||
3'UTR of TCEANC (miRNA target sites are highlighted) |
>TCEANC|NM_152634|3'UTR 1 CTGTAAATCAGTGTTCTCTTAACAGATAACCGGAGTGATACCTTTTATTTGTACAACCCTTTTGTGCTTTTAAAAATCTT 81 ATACACACTACTCTCTAAAACAGAAAAAGGAGGAAAGAAAGTCGTTAGCTGAAGCTGCCACCACCATCCCTAAAAGTTAC 161 AGTTTGGGGAGAGGGAGTGGATGACTATTTATATTGTGCCTTGTGGCCATTTAGTACCTTACTGTAGACAGAGTGTGGGT 241 GAGAACAGCCCAGCATAAACTGGGAGACTGTGGGAAATGCATTCCCAGGCCTCACACCATTGAATCCGAATCTGCATTTT 321 GACAGGATCCCCAGGTAATCTTCCAGGATAGGATAGTTTGAGAAGTGCTACTTTAGCAATAGGCCTGTGGCTCTCAGCAG 401 TGGCTGCATATTAAAATCATCTGGGAAGCTTTGAAAACCCACTGGTGCTGAGACCCCACCCTAGAACAATTCAGTTGGAA 481 CCTATGAGATGGGACCCAGGCATCAACATTTCTTTTTTCATTCCTCAAGTTATTTTAAGATGCAGTCAGAGTTGAGAACT 561 ACTCAGAAATAGGCTCTCATTTGATCCTTTTTACAGCTCTAAGACAAGAATGTTATTCCAGGCACTTCACGAATGAGGAA 641 ACAGGTCCACAGAGGTGTGGTGACATGTCCAAGTGACACAACCATAAATAGTACCAATTCTGACAGATCCCAGATTTTCT 721 CCCTCCTGACTCACTGAGACTGGCTCAATATCGACTTCTGAGAAATGTATTCCTGGAGGTCGGGGACAAAATGAAGAATG 801 TGTTTAAACTCCAACATTGGGTGACTAGATCTTCATTCTTTTCCCCTCTCTTTTCTCATTTATAGGTCTCCCTTCAACCA 881 CAAAAGTCACCCTGGAACTCATCCCGCAGTTAGAATTTTGTTTGGAGCCCTCTTGCTTAGTTGAAGGAGTTTCGTAGTTG 961 TTTTTTGTTTTTGTTTTTGTTTTTGTTTTTTCCCCCTGTGAACAGGTTTTTCGGGGGTATGTAAACTCTAGGATGTTTAG 1041 TTTCTGATGTCAGGAGTCTTCATGTTCTCAAGGACAAGTGTCCTTGAGATGGACATTAATGGTCATTAGTCTGTCAGAGG 1121 AAGCCCATCACTTTAGCCTTTGAATGTAGTAACAGACGTTTATCTAATAAATGAATTGAAGATAAAATTACCTCTTTGAG 1201 GCCTTTGCAAACAGTGTTTAACCAGTTTATATAATTGTTTGACTACAACACGCCTTCTATGTGATTATGGCTGATTTTTT 1281 TTCCTTAAAAAACTCATGGAATGTTCACCGTTTTATAGTTTTAAAAAGTTTACTTTGGCGGTCTCTACAAACCTACCATT 1361 TCACTTTCTCACCAGTTCTTTTCTCCTAACTCTCTTCCTTTGTTGGAGCTCTGAAGGCCTAACTGTGTGTACACTTTACC 1441 TGCCTGACAGAATTCTCCAAAACATGCATAAAAGTAAAATATGTTCGTATTTTCAAATAATTTGGAAGAGTCGGCTCAAT 1521 GCCATCAAGTGTAAAATCTATTTTGATATACTTGCTCTCCGTGTCTTCCCAGGGCTGCTTTTTGTGATGCAACATGTTTA 1601 GTCCTTAACTTGCAAGGTCATCTAAAACTTGAAGTTTCACAAAGTGTGGTTTCATATGACTTGGAATAATCTGAAAAACT 1681 ATTCAGTGGTTACGAAAGAGCACAGCACATAAAAACCAAATTTGATTAGTTCAAGTCGGTGTTTATGTTTTGCTTTGGGG 1761 GTTTGTGTGTATGTGTGTAGTTTTTATTTATATTGGAATTTGGCAAACTAAATGTTCAGACAAATAAAAGTAATTAAAAT 1841 GGAAAAAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | BC-1 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine
PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
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CLIP-seq Support 1 for dataset GSM796037 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000380600.1 | 3UTR | UCAAGUUAUUUUAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM796038 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000380600.1 | 3UTR | UCAAGUUAUUUUAAG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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111 hsa-miR-3915 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT059544 | PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase type 1 alpha | 2 | 2 | ||||||||
MIRT081703 | ZNF507 | zinc finger protein 507 | 2 | 2 | ||||||||
MIRT083311 | ZCCHC3 | zinc finger CCHC-type containing 3 | 2 | 6 | ||||||||
MIRT119046 | SFT2D3 | SFT2 domain containing 3 | 2 | 2 | ||||||||
MIRT189381 | TXLNA | taxilin alpha | 2 | 4 | ||||||||
MIRT195895 | C16ORF72 | chromosome 16 open reading frame 72 | 2 | 6 | ||||||||
MIRT223807 | OXR1 | oxidation resistance 1 | 2 | 2 | ||||||||
MIRT292954 | ZNF146 | zinc finger protein 146 | 2 | 4 | ||||||||
MIRT293949 | RPL13A | ribosomal protein L13a | 2 | 6 | ||||||||
MIRT300900 | KREMEN1 | kringle containing transmembrane protein 1 | 2 | 2 | ||||||||
MIRT339332 | SESN2 | sestrin 2 | 2 | 2 | ||||||||
MIRT349304 | ZNF317 | zinc finger protein 317 | 2 | 2 | ||||||||
MIRT364736 | TOR1B | torsin family 1 member B | 2 | 2 | ||||||||
MIRT366233 | VMA21 | VMA21, vacuolar ATPase assembly factor | 2 | 2 | ||||||||
MIRT384605 | CLIC4 | chloride intracellular channel 4 | 2 | 2 | ||||||||
MIRT401745 | HLA-DRA | major histocompatibility complex, class II, DR alpha | 2 | 2 | ||||||||
MIRT443169 | UBL3 | ubiquitin like 3 | 2 | 2 | ||||||||
MIRT444215 | METTL12 | methyltransferase like 12 | 2 | 2 | ||||||||
MIRT444375 | SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | 2 | 2 | ||||||||
MIRT445340 | TCEANC | transcription elongation factor A N-terminal and central domain containing | 2 | 2 | ||||||||
MIRT445474 | KDM6A | lysine demethylase 6A | 2 | 2 | ||||||||
MIRT445598 | CAMK2N1 | calcium/calmodulin dependent protein kinase II inhibitor 1 | 2 | 2 | ||||||||
MIRT445630 | TMEM50A | transmembrane protein 50A | 2 | 2 | ||||||||
MIRT446012 | VNN1 | vanin 1 | 2 | 2 | ||||||||
MIRT446115 | ASTN1 | astrotactin 1 | 2 | 2 | ||||||||
MIRT446248 | ELP2 | elongator acetyltransferase complex subunit 2 | 2 | 2 | ||||||||
MIRT446382 | SYNCRIP | synaptotagmin binding cytoplasmic RNA interacting protein | 2 | 2 | ||||||||
MIRT446940 | ZMAT3 | zinc finger matrin-type 3 | 2 | 2 | ||||||||
MIRT446967 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | 2 | 2 | ||||||||
MIRT447178 | PGRMC2 | progesterone receptor membrane component 2 | 2 | 2 | ||||||||
MIRT447209 | APBB2 | amyloid beta precursor protein binding family B member 2 | 2 | 2 | ||||||||
MIRT447237 | IHH | indian hedgehog | 2 | 2 | ||||||||
MIRT447807 | EMX1 | empty spiracles homeobox 1 | 2 | 2 | ||||||||
MIRT447853 | RRP8 | ribosomal RNA processing 8 | 2 | 4 | ||||||||
MIRT448054 | MMP15 | matrix metallopeptidase 15 | 2 | 2 | ||||||||
MIRT448094 | RASD2 | RASD family member 2 | 2 | 2 | ||||||||
MIRT448704 | KLHL11 | kelch like family member 11 | 2 | 2 | ||||||||
MIRT448851 | FEM1C | fem-1 homolog C | 2 | 2 | ||||||||
MIRT449488 | ZBTB4 | zinc finger and BTB domain containing 4 | 2 | 2 | ||||||||
MIRT449785 | C1orf109 | chromosome 1 open reading frame 109 | 2 | 2 | ||||||||
MIRT450774 | PDE3A | phosphodiesterase 3A | 2 | 2 | ||||||||
MIRT451124 | ZNF99 | zinc finger protein 99 | 2 | 2 | ||||||||
MIRT452676 | GPR156 | G protein-coupled receptor 156 | 2 | 2 | ||||||||
MIRT452888 | PSD4 | pleckstrin and Sec7 domain containing 4 | 2 | 2 | ||||||||
MIRT453188 | ACSF2 | acyl-CoA synthetase family member 2 | 2 | 2 | ||||||||
MIRT453353 | ZNF3 | zinc finger protein 3 | 2 | 2 | ||||||||
MIRT454502 | ZFYVE27 | zinc finger FYVE-type containing 27 | 2 | 2 | ||||||||
MIRT454629 | FAM83H | family with sequence similarity 83 member H | 2 | 2 | ||||||||
MIRT455183 | AGTRAP | angiotensin II receptor associated protein | 2 | 2 | ||||||||
MIRT458204 | FOXL2 | forkhead box L2 | 2 | 2 | ||||||||
MIRT458723 | CES2 | carboxylesterase 2 | 2 | 2 | ||||||||
MIRT458942 | SAMD4B | sterile alpha motif domain containing 4B | 2 | 2 | ||||||||
MIRT460304 | FLCN | folliculin | 2 | 2 | ||||||||
MIRT460989 | SYT7 | synaptotagmin 7 | 2 | 2 | ||||||||
MIRT461697 | ZNF426 | zinc finger protein 426 | 2 | 2 | ||||||||
MIRT461903 | NECAB3 | N-terminal EF-hand calcium binding protein 3 | 2 | 2 | ||||||||
MIRT462193 | NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1 | 2 | 2 | ||||||||
MIRT462290 | PPM1H | protein phosphatase, Mg2+/Mn2+ dependent 1H | 2 | 2 | ||||||||
MIRT463795 | XPOT | exportin for tRNA | 2 | 2 | ||||||||
MIRT464649 | UBE2V1 | ubiquitin conjugating enzyme E2 V1 | 2 | 4 | ||||||||
MIRT465911 | TMEM189-UBE2V1 | TMEM189-UBE2V1 readthrough | 2 | 4 | ||||||||
MIRT465992 | TMEM189 | transmembrane protein 189 | 2 | 4 | ||||||||
MIRT466302 | TIMM22 | translocase of inner mitochondrial membrane 22 | 2 | 2 | ||||||||
MIRT466575 | TBC1D2B | TBC1 domain family member 2B | 2 | 2 | ||||||||
MIRT470558 | POU2F1 | POU class 2 homeobox 1 | 2 | 2 | ||||||||
MIRT471333 | PERP | PERP, TP53 apoptosis effector | 2 | 2 | ||||||||
MIRT471659 | PALM2 | paralemmin 2 | 2 | 2 | ||||||||
MIRT472363 | TSPAN1 | tetraspanin 1 | 2 | 2 | ||||||||
MIRT473468 | MCFD2 | multiple coagulation factor deficiency 2 | 2 | 2 | ||||||||
MIRT474702 | KIF3A | kinesin family member 3A | 2 | 2 | ||||||||
MIRT476067 | GRIN2A | glutamate ionotropic receptor NMDA type subunit 2A | 2 | 2 | ||||||||
MIRT476077 | GRB2 | growth factor receptor bound protein 2 | 2 | 2 | ||||||||
MIRT476423 | GBA2 | glucosylceramidase beta 2 | 2 | 2 | ||||||||
MIRT476463 | GATAD2B | GATA zinc finger domain containing 2B | 2 | 2 | ||||||||
MIRT477877 | DYNLL2 | dynein light chain LC8-type 2 | 2 | 2 | ||||||||
MIRT478240 | DDX3X | DEAD-box helicase 3, X-linked | 2 | 4 | ||||||||
MIRT479460 | CDK6 | cyclin dependent kinase 6 | 2 | 2 | ||||||||
MIRT481030 | BAZ2A | bromodomain adjacent to zinc finger domain 2A | 2 | 2 | ||||||||
MIRT491496 | HLA-DOA | major histocompatibility complex, class II, DO alpha | 2 | 2 | ||||||||
MIRT497585 | SLC23A1 | solute carrier family 23 member 1 | 2 | 2 | ||||||||
MIRT498542 | TMEM30B | transmembrane protein 30B | 2 | 2 | ||||||||
MIRT499263 | NBPF11 | NBPF member 11 | 2 | 2 | ||||||||
MIRT504698 | ZNF117 | zinc finger protein 117 | 2 | 2 | ||||||||
MIRT511288 | KLHL15 | kelch like family member 15 | 2 | 4 | ||||||||
MIRT523121 | HSP90B1 | heat shock protein 90 beta family member 1 | 2 | 4 | ||||||||
MIRT529601 | H1F0 | H1 histone family member 0 | 2 | 2 | ||||||||
MIRT533481 | TRIM71 | tripartite motif containing 71 | 2 | 2 | ||||||||
MIRT535571 | NUP37 | nucleoporin 37 | 2 | 4 | ||||||||
MIRT537869 | EDA2R | ectodysplasin A2 receptor | 2 | 2 | ||||||||
MIRT538010 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | 2 | 2 | ||||||||
MIRT552681 | YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta | 2 | 4 | ||||||||
MIRT554986 | RAB39B | RAB39B, member RAS oncogene family | 2 | 2 | ||||||||
MIRT556659 | KMT2D | lysine methyltransferase 2D | 2 | 4 | ||||||||
MIRT557437 | GTPBP2 | GTP binding protein 2 | 2 | 2 | ||||||||
MIRT560813 | CRTAP | cartilage associated protein | 2 | 2 | ||||||||
MIRT562115 | IGFBP5 | insulin like growth factor binding protein 5 | 2 | 2 | ||||||||
MIRT563103 | IFRD2 | interferon related developmental regulator 2 | 2 | 2 | ||||||||
MIRT574199 | LMNB1 | lamin B1 | 2 | 2 | ||||||||
MIRT623920 | FMNL3 | formin like 3 | 2 | 2 | ||||||||
MIRT626551 | NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 | 2 | 2 | ||||||||
MIRT645458 | ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | 2 | 2 | ||||||||
MIRT649082 | CACNA1B | calcium voltage-gated channel subunit alpha1 B | 2 | 2 | ||||||||
MIRT659477 | CLDN1 | claudin 1 | 2 | 2 | ||||||||
MIRT667950 | HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | 2 | 2 | ||||||||
MIRT701981 | MIER3 | MIER family member 3 | 2 | 2 | ||||||||
MIRT708694 | TFDP2 | transcription factor Dp-2 | 2 | 2 | ||||||||
MIRT709649 | DFFB | DNA fragmentation factor subunit beta | 2 | 2 | ||||||||
MIRT710090 | FAM229B | family with sequence similarity 229 member B | 2 | 2 | ||||||||
MIRT718396 | ALDH1A3 | aldehyde dehydrogenase 1 family member A3 | 2 | 2 | ||||||||
MIRT724972 | TNS1 | tensin 1 | 2 | 2 | ||||||||
MIRT756050 | HRH4 | histamine receptor H4 | 2 | 1 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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