miRTarBase - #MIRT445947


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pre-miRNA Information
pre-miRNA hsa-mir-4476   
Genomic Coordinates chr9: 36893462 - 36893531
Description Homo sapiens miR-4476 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4476
Sequence 45| CAGGAAGGAUUUAGGGACAGGC |66
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 6 9 - 36893482 29233923 MiREDiBase
A-to-I 9 9 - 36893479 29233923 MiREDiBase
A-to-I 13 9 - 36893475 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs978640498 3 dbSNP
rs1019792440 6 dbSNP
rs1008364367 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SCML4   
Synonyms dJ47M23.1
Description Scm polycomb group protein like 4
Transcript NM_198081   
Expression
Putative miRNA Targets on SCML4
3'UTR of SCML4
(miRNA target sites are highlighted)		 
>SCML4|NM_198081|3'UTR
   1 CTTTTTTAAAAAGACAGAAGCGAAACCCAAAACAACAGATCCCAAGATTATCTTCTGCCTTACCAATATCCCGCCAACAT
  81 CACAAACTAGACTCTCCTCTTAAAATTAACAGCCACAGAGACGTGGTCTTTTTATAAAACTTGTGAATCTTTGCCTTTTG
 161 AAGAATTTAACATGGACCTTTTCGAGAGGCTCCTCTGTGTTCATAATTTGCCAAAAAATTACAAAAGCCTGTGATTTTTA
 241 ACATCCCTGTTATGCTGGTTTCTCTTAAAGTGGGTCCTATTTGCATAACGAGAGAGTGGGGAACTGAATGCTTATGCCCA
 321 AGGAGAGTTCTGGAGGGTTCAAAGGATGAAAGAAGGACCTTTGTCCCTGCGGTCTCTGCAGGGACAACCCCCTCAGCACC
 401 ATCTGCCTCTAACTCTGACCTGGGGACCTATCCATGTGAGCCTTGTTTGCCTCAGCTCTGGAAGCTGACTTCTGAAGATG
 481 ACTGCCTCACCTTGCACTGTCTGGAAAACTTGAATTATTTTACGCCGTGAAAGAAAAAGGAAAAAAAAAAAAATCTTTTC
 561 TGTTCCTAGAAAATCTGAAGTACTGTGTTTCTCCGCTAGAGGGCAGACTGCTAATGAAATTTCAGGACCCTCACTGACTG
 641 CAGTAGCAGGATTGTTCAGTACTGAGTGGATGGGTTAGGGTGTCTGTGAACAAGATCTAGCCCACACAGAAACAGGGGAT
 721 TTATTCCACAGTTAGCACCACAGATTGCGACTTGGGAAGAAACCATCAGCTAGAGGGGTCTAGTTCGTATCCAATCATTA
 801 TTGACTGACTGACTGATACTCAACTAGCAAAGGCAAGAATTTGGAAGCACGCTCTACCCAGATGGGACTTTGGAGTTCCT
 881 TCCCTTCCAGAGTCCTTATTGAGGTGTTGAAGTGTTGGCATGCCGAAGAATCTTAGTGACATTTAGCCATGGGTGTTTCT
 961 TTAAAAAAGGAAAAGAAAATGTCTCAACGAAGCTTTGAAATGGGAGAGTGTTGATTTCTAGTTACATTGCTGGGTTATGT
1041 AGTTGTATCTGTGGCTAATTTTTCTAGTCCTCAACAAATACACAGACATGCTATTATGGGGTTTAATTCAATTTACAAAT
1121 AGGTTTTCCTTCCTCACAGTGGAGTAATAGAAAAAATTGATTTTCTGCTCCTTTGCAGCTGTGTCCAGAGACGGACAATG
1201 AATCCACAATTTATTAGGCAGAGGCACAACTTCTCCACCATTCGTTTTATCCTTCTCTTTTCTCTGTTTCCCTCCACCTC
1281 TCTTCTTCTTCTTTCACACTGAGCAGAAAACATATCTTCAAAATGAATTCGCCTTTGCCATGTGCATATTCTCTTCCTTA
1361 AAAGGACATCAACAGTGTTGGAGATGAGGAGATGAACATTAGATTTTGGAATTTCTGGGAGGGAGAGGGTTAGGGATGAC
1441 TCAGGGCCTCCCTTCGCCCAAAGGTGAATCAGAAAAGGCACCCCTTTCTCTGGGATACAACCTGAGCAGGGGTCTCAGCT
1521 GGCAAGTGGAGCAGGGTGGGGGCTCAACCTCCTCACCGCTTGATCAGCTGCCGTTGTACAGAGCATGACCTGTATAACCT
1601 TGAGGGCAGCCCTGGGTAGATCTGCAGAGTGACCCTCTATATAGTTAGAATCCAGATGAAGGCCATAAGAAATAGTCCAT
1681 GCCATGCCGTTAGGCCCACTTTCATGTGCAGTACTTGAGAAAGCACATCGTAGCCTCCTTTTCAGACACACAAATGGCGG
1761 CTGGACTGAGAGCATGGCAGAGAAGGGGAGGAGGAGAATGTACTAAACTTGCTCACTGAATTGAGCTTGAGTTATTAGAT
1841 TGTAGAAGAGCTTGATGTCTGGTGATTTTGTTACAGGAAGGGGGTCCCGATCCAGACCCCAAGAGAGGGCTCTTGGATCT
1921 CATGCAAGAAAGAATTCAGGGTGAGTCCATAAAGTAAAGTGAAAGCAAGTTTATTAAGAAAGTAAAGGAAGGAAAGAATG
2001 GCTACCCCATAGTCAAAGCAGCTCTGAGGGCTGCTGGTTGCCCATTTTTATGTTTATTTCTTGATATGCTAAACAAGGGG
2081 TGGATTATTCATGCCTCCCCCTTTTAGATCATATAGGGTAACTTCCTGATGTTGCCATGGCATTTGTAAACCGTCATGGC
2161 ACTGGTGGTAGTATAGCAGCGAGGACAACCAGAGGTCACTCTCGTTGCCATCTTGGTTTTGGTGGGTTTTAGCCAACTTC
2241 TTTACTGCAACCTGTTTTATCAGAAGGTCTTTATGACCTATATCTTGTGCTGACCTCCTGTCTCATCCTGTGACTCAGAA
2321 TGCTTTAGCCATCTGGGAATGCAGCCCAGTAGGTCTCAGCCTCATTTTACCCAGCTCCCATTCAAGATGGAGTTGCTCTG
2401 GTTCAAATGCCTCTGACAGGTTCAGCACCTGAGAAAAGTACCTTGAATCAGGCCTTGGGGCAGAGTCTTCAAGATTTTAA
2481 GGTGATAGGGCCTGTCTCTTAAGAATTTATTAATCGTAAGTGCTCACTGCTGGTTTAGAGTTAGATACATTTCCCTCAAA
2561 ACAGCCATGGGCAGGTTATGTACTCAGAACTGCCAGGGTGAAAACAATGAGATCCAGAAAAATCCCACAACAATCCAGGT
2641 TTTTCACTCCTCTTTTTTTTCTCAATCTTCCGATACTTGTGGTACCTCTTCCATCAACAGATACCTCATGTAGTGACTTC
2721 CAGTATCAAGTTTTCAAAACTTCCTACCCACCCTCATCAGTGCCTCCTTCACTACAGAGTCACAAACATTGGTGCTCTCA
2801 AATAAAAATCAGCCCCAAACAATGTCAAAGAGATCCCTTGAGTAGTTTTCAGGCGAGAGATATGTTCTCATTTCAAGTCT
2881 TGGAGAAAACTGGATCCATGTTCACGTGGAACTTCTCTCGCGGAGGTGCTATCTCATTTTGCATTAAACTTTAAGCAGGA
2961 CAGATTGCTGAAGCCATGATATTTAAGGTTTGACTTTTTAAAAATCTCATTACTCTTAAAATAAATGCTGCCACATCAGA
3041 GAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cggacagggauuuAGGAAGGAc 5'
                       |||||||| 
Target 5' tacaaataggtttTCCTTCCTc 3'
 1114 - 1135 145.00 -10.30
2 
miRNA  3' cggACAGGGAUUUAGGAAGGAc 5'
             ||| | ||   :|||||| 
Target 5' ccaTGTGCATATTCTCTTCCTt 3'
 1338 - 1359 139.00 -12.20
3 
miRNA  3' cggaCAGGGAUUU--AGGAAGGac 5'
              | |::|::|  |||||||  
Target 5' atggGACTTTGGAGTTCCTTCCct 3'
 862 - 885 136.00 -13.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31586853 21 COSMIC
COSN30121902 22 COSMIC
COSN28871783 58 COSMIC
COSN31602441 66 COSMIC
COSN19639985 87 COSMIC
COSN31604322 124 COSMIC
COSN30116740 183 COSMIC
COSN28774611 267 COSMIC
COSN2133061 355 COSMIC
COSN27195855 541 COSMIC
COSN14870276 988 COSMIC
COSN9289754 1070 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs116345050 1 dbSNP
rs1546961 2 dbSNP
rs1413452115 3 dbSNP
rs1354068406 6 dbSNP
rs529007353 20 dbSNP
rs764791386 21 dbSNP
rs1416627943 22 dbSNP
rs1343670124 34 dbSNP
rs1317895400 36 dbSNP
rs766650215 38 dbSNP
rs1399931518 42 dbSNP
rs556760919 45 dbSNP
rs777168006 46 dbSNP
rs926649286 47 dbSNP
rs1397628496 55 dbSNP
rs980768207 60 dbSNP
rs879142205 65 dbSNP
rs1401458054 71 dbSNP
rs1009597982 72 dbSNP
rs763104781 73 dbSNP
rs1546962 87 dbSNP
rs1362154213 89 dbSNP
rs1477121271 92 dbSNP
rs993712424 96 dbSNP
rs570934396 100 dbSNP
rs547843918 101 dbSNP
rs961933881 106 dbSNP
rs1015961163 111 dbSNP
rs1188495268 117 dbSNP
rs191786246 122 dbSNP
rs888869646 123 dbSNP
rs566009281 128 dbSNP
rs1050016029 134 dbSNP
rs1253582793 139 dbSNP
rs997206098 149 dbSNP
rs571501416 156 dbSNP
rs1187953364 157 dbSNP
rs1201995657 169 dbSNP
rs1345367735 173 dbSNP
rs114924838 183 dbSNP
rs187419279 184 dbSNP
rs1421190370 185 dbSNP
rs1036148699 186 dbSNP
rs1377936503 208 dbSNP
rs1280236059 216 dbSNP
rs1400643529 219 dbSNP
rs1313805915 221 dbSNP
rs1385620260 224 dbSNP
rs1238610478 235 dbSNP
rs1308699233 241 dbSNP
rs1355103913 245 dbSNP
rs944436918 252 dbSNP
rs1546963 258 dbSNP
rs1483021449 264 dbSNP
rs6903929 267 dbSNP
rs1244676021 268 dbSNP
rs931615138 273 dbSNP
rs746566495 289 dbSNP
rs936697959 290 dbSNP
rs926699998 293 dbSNP
rs151030572 296 dbSNP
rs1358229318 300 dbSNP
rs949430513 303 dbSNP
rs946918731 310 dbSNP
rs917816006 312 dbSNP
rs972041832 316 dbSNP
rs1445284457 333 dbSNP
rs962185644 336 dbSNP
rs960762909 339 dbSNP
rs142836349 340 dbSNP
rs980813195 347 dbSNP
rs969755338 355 dbSNP
rs1442627367 358 dbSNP
rs1456252178 365 dbSNP
rs541063886 370 dbSNP
rs897702011 371 dbSNP
rs1188952619 377 dbSNP
rs1014747942 381 dbSNP
rs1258593838 385 dbSNP
rs11153076 387 dbSNP
rs1334175262 389 dbSNP
rs1282487441 391 dbSNP
rs1247346419 395 dbSNP
rs11153075 396 dbSNP
rs1401683177 407 dbSNP
rs1444909951 410 dbSNP
rs984597498 413 dbSNP
rs542172230 416 dbSNP
rs1050577201 420 dbSNP
rs868545704 427 dbSNP
rs11153074 434 dbSNP
rs556824221 436 dbSNP
rs1043992518 438 dbSNP
rs1316241523 455 dbSNP
rs1217797342 456 dbSNP
rs946950016 458 dbSNP
rs914099335 460 dbSNP
rs997574119 464 dbSNP
rs1403123549 485 dbSNP
rs901536786 488 dbSNP
rs1488506286 495 dbSNP
rs988280918 496 dbSNP
rs939490709 498 dbSNP
rs1477259381 501 dbSNP
rs1020277442 510 dbSNP
rs1009860045 512 dbSNP
rs928073658 521 dbSNP
rs981230207 522 dbSNP
rs1164488169 523 dbSNP
rs1472952082 524 dbSNP
rs778879085 526 dbSNP
rs1362811781 528 dbSNP
rs1176581499 529 dbSNP
rs1441250702 533 dbSNP
rs1053921556 534 dbSNP
rs1338714960 539 dbSNP
rs1238728283 540 dbSNP
rs1213056249 541 dbSNP
rs1363794030 541 dbSNP
rs1027654928 546 dbSNP
rs540020246 549 dbSNP
rs76962114 553 dbSNP
rs1322206789 554 dbSNP
rs35793191 554 dbSNP
rs796171575 554 dbSNP
rs1193917827 558 dbSNP
rs936833958 561 dbSNP
rs1476611569 562 dbSNP
rs905252903 568 dbSNP
rs1413719488 572 dbSNP
rs1287866061 574 dbSNP
rs1165620089 586 dbSNP
rs1358683718 587 dbSNP
rs973342671 595 dbSNP
rs961942878 601 dbSNP
rs1211689851 602 dbSNP
rs1347148429 604 dbSNP
rs1445574015 607 dbSNP
rs1254566203 608 dbSNP
rs757067336 609 dbSNP
rs368565521 625 dbSNP
rs550555322 628 dbSNP
rs181514512 629 dbSNP
rs1238435833 630 dbSNP
rs1248074200 641 dbSNP
rs917965813 642 dbSNP
rs553970339 648 dbSNP
rs1379498232 652 dbSNP
rs1008755293 663 dbSNP
rs1285936451 666 dbSNP
rs972479641 666 dbSNP
rs1440281653 669 dbSNP
rs1208463067 673 dbSNP
rs1237257273 674 dbSNP
rs1310429286 678 dbSNP
rs1445826034 688 dbSNP
rs1440902292 694 dbSNP
rs1378593576 697 dbSNP
rs749080686 700 dbSNP
rs541827981 701 dbSNP
rs1324982524 702 dbSNP
rs890249417 704 dbSNP
rs777642214 705 dbSNP
rs984566418 707 dbSNP
rs1406528334 712 dbSNP
rs1454561774 713 dbSNP
rs1156400128 716 dbSNP
rs1375994606 721 dbSNP
rs371206197 729 dbSNP
rs1280719980 730 dbSNP
rs756068605 732 dbSNP
rs996324341 735 dbSNP
rs1218260172 736 dbSNP
rs1421125969 744 dbSNP
rs1278417948 749 dbSNP
rs12216157 759 dbSNP
rs1205930144 763 dbSNP
rs1192743269 767 dbSNP
rs966097247 777 dbSNP
rs1457669137 778 dbSNP
rs1182630465 786 dbSNP
rs1019909744 787 dbSNP
rs1172193773 794 dbSNP
rs945685225 800 dbSNP
rs1477029332 817 dbSNP
rs1168199247 819 dbSNP
rs892737819 819 dbSNP
rs1201133841 821 dbSNP
rs568374434 825 dbSNP
rs1328822946 829 dbSNP
rs548530760 834 dbSNP
rs1214789134 842 dbSNP
rs1325188722 848 dbSNP
rs529199114 850 dbSNP
rs148533443 857 dbSNP
rs147484616 874 dbSNP
rs765421689 884 dbSNP
rs1045191765 899 dbSNP
rs1366157935 909 dbSNP
rs905396612 917 dbSNP
rs117939055 924 dbSNP
rs920624249 926 dbSNP
rs973416439 928 dbSNP
rs1269883641 932 dbSNP
rs1436589241 941 dbSNP
rs190317232 951 dbSNP
rs1422635519 952 dbSNP
rs907798149 969 dbSNP
rs1295810925 970 dbSNP
rs1169542884 973 dbSNP
rs1388434657 976 dbSNP
rs1404268828 979 dbSNP
rs2295279 988 dbSNP
rs954605907 992 dbSNP
rs1036336582 1001 dbSNP
rs528151984 1006 dbSNP
rs940714050 1008 dbSNP
rs1276766116 1011 dbSNP
rs527344373 1040 dbSNP
rs995966742 1042 dbSNP
rs968883500 1050 dbSNP
rs1021305689 1052 dbSNP
rs114436958 1062 dbSNP
rs891427520 1064 dbSNP
rs577510096 1066 dbSNP
rs1292583555 1079 dbSNP
rs1490917695 1084 dbSNP
rs1191745707 1087 dbSNP
rs1262251122 1095 dbSNP
rs1052669605 1099 dbSNP
rs1048997099 1101 dbSNP
rs1195006179 1102 dbSNP
rs931807199 1105 dbSNP
rs1366661673 1117 dbSNP
rs1172802090 1124 dbSNP
rs554545044 1125 dbSNP
rs1163745732 1137 dbSNP
rs1004201012 1139 dbSNP
rs1417534611 1141 dbSNP
rs1297170340 1143 dbSNP
rs764567723 1144 dbSNP
rs1383138933 1149 dbSNP
rs921807356 1150 dbSNP
rs1045629093 1154 dbSNP
rs761181782 1155 dbSNP
rs1475035490 1157 dbSNP
rs976322836 1157 dbSNP
rs1214488999 1165 dbSNP
rs1260382113 1165 dbSNP
rs1486285607 1170 dbSNP
rs1206680957 1178 dbSNP
rs948218011 1180 dbSNP
rs1262651729 1183 dbSNP
rs965790420 1185 dbSNP
rs368845820 1192 dbSNP
rs771665283 1193 dbSNP
rs576840671 1208 dbSNP
rs745535769 1236 dbSNP
rs556883658 1243 dbSNP
rs969633397 1244 dbSNP
rs1023772610 1255 dbSNP
rs907870375 1264 dbSNP
rs1264124664 1266 dbSNP
rs747541179 1274 dbSNP
rs1452597251 1287 dbSNP
rs1209862939 1294 dbSNP
rs987427243 1297 dbSNP
rs1014186720 1300 dbSNP
rs774190483 1301 dbSNP
rs546464446 1312 dbSNP
rs1254078590 1313 dbSNP
rs1460681680 1319 dbSNP
rs1004827928 1330 dbSNP
rs373301259 1331 dbSNP
rs1401251036 1339 dbSNP
rs143170069 1340 dbSNP
rs968482734 1344 dbSNP
rs931859688 1353 dbSNP
rs921852109 1354 dbSNP
rs1360737214 1364 dbSNP
rs955744389 1374 dbSNP
rs1040179000 1383 dbSNP
rs1173476747 1384 dbSNP
rs534050380 1385 dbSNP
rs912961693 1389 dbSNP
rs1469628086 1390 dbSNP
rs1177526491 1392 dbSNP
rs988994430 1394 dbSNP
rs1408950499 1397 dbSNP
rs770706561 1398 dbSNP
rs1035746412 1404 dbSNP
rs1003828806 1408 dbSNP
rs1393399306 1415 dbSNP
rs1299506537 1419 dbSNP
rs1323037098 1438 dbSNP
rs185612490 1446 dbSNP
rs1264765572 1447 dbSNP
rs925571195 1451 dbSNP
rs1316052914 1454 dbSNP
rs1409343396 1455 dbSNP
rs554696162 1456 dbSNP
rs969599322 1457 dbSNP
rs1168647593 1478 dbSNP
rs1267746123 1479 dbSNP
rs115998836 1481 dbSNP
rs1013738681 1493 dbSNP
rs1200690079 1506 dbSNP
rs751128400 1509 dbSNP
rs569656439 1511 dbSNP
rs1408770615 1513 dbSNP
rs140939200 1515 dbSNP
rs1463612595 1518 dbSNP
rs899300240 1521 dbSNP
rs1345184655 1523 dbSNP
rs539303051 1526 dbSNP
rs1338400082 1531 dbSNP
rs1285011202 1538 dbSNP
rs570568834 1540 dbSNP
rs887863736 1542 dbSNP
rs1037826100 1543 dbSNP
rs1482399297 1543 dbSNP
rs1027576089 1548 dbSNP
rs547539957 1554 dbSNP
rs527422607 1557 dbSNP
rs900393439 1558 dbSNP
rs1271554731 1559 dbSNP
rs1457731078 1566 dbSNP
rs1040717948 1570 dbSNP
rs1474649247 1570 dbSNP
rs1186245583 1572 dbSNP
rs764540 1573 dbSNP
rs1052210692 1586 dbSNP
rs1317922238 1592 dbSNP
rs891655752 1607 dbSNP
rs1161813264 1612 dbSNP
rs1365012154 1623 dbSNP
rs1052943669 1624 dbSNP
rs1305215931 1625 dbSNP
rs1226325265 1628 dbSNP
rs1380847692 1632 dbSNP
rs762992465 1633 dbSNP
rs547914751 1634 dbSNP
rs1303261246 1639 dbSNP
rs935703912 1648 dbSNP
rs1445704704 1651 dbSNP
rs925705828 1657 dbSNP
rs1398034694 1658 dbSNP
rs921845736 1662 dbSNP
rs974653045 1678 dbSNP
rs947256000 1679 dbSNP
rs1359504664 1682 dbSNP
rs914403112 1684 dbSNP
rs147318907 1688 dbSNP
rs181382667 1689 dbSNP
rs546527552 1697 dbSNP
rs1215527853 1698 dbSNP
rs1035417812 1699 dbSNP
rs1487164852 1700 dbSNP
rs916827279 1704 dbSNP
rs549013474 1705 dbSNP
rs992855773 1717 dbSNP
rs1385114633 1721 dbSNP
rs981534461 1722 dbSNP
rs960903817 1727 dbSNP
rs577581615 1729 dbSNP
rs1439397828 1730 dbSNP
rs1015466336 1746 dbSNP
rs1400332597 1748 dbSNP
rs1318793950 1751 dbSNP
rs1346725947 1754 dbSNP
rs1450415235 1755 dbSNP
rs756009783 1758 dbSNP
rs1458599507 1759 dbSNP
rs1012498846 1761 dbSNP
rs952099318 1772 dbSNP
rs1016426282 1783 dbSNP
rs149635588 1793 dbSNP
rs1027713327 1799 dbSNP
rs1005023805 1805 dbSNP
rs1285440015 1811 dbSNP
rs1319134707 1828 dbSNP
rs748079857 1837 dbSNP
rs780132314 1843 dbSNP
rs886539799 1857 dbSNP
rs540802544 1865 dbSNP
rs1231238332 1870 dbSNP
rs1312936570 1870 dbSNP
rs1051814484 1875 dbSNP
rs1159336908 1884 dbSNP
rs1410391190 1885 dbSNP
rs1239177738 1888 dbSNP
rs933323444 1890 dbSNP
rs1175377612 1892 dbSNP
rs1311180140 1902 dbSNP
rs996115373 1909 dbSNP
rs900530003 1911 dbSNP
rs574873766 1916 dbSNP
rs555039243 1919 dbSNP
rs750469827 1927 dbSNP
rs1280946914 1931 dbSNP
rs188247767 1938 dbSNP
rs1366797007 1940 dbSNP
rs1262904025 1941 dbSNP
rs775272186 1951 dbSNP
rs947287103 1954 dbSNP
rs1456423398 1961 dbSNP
rs1437350160 1964 dbSNP
rs935838917 1965 dbSNP
rs1234832125 1980 dbSNP
rs904257403 1982 dbSNP
rs1044199490 1988 dbSNP
rs948408677 1990 dbSNP
rs928378151 2001 dbSNP
rs981181727 2005 dbSNP
rs1180866034 2016 dbSNP
rs1410055813 2022 dbSNP
rs916943270 2030 dbSNP
rs970164140 2037 dbSNP
rs1267214012 2038 dbSNP
rs1283101461 2040 dbSNP
rs1346509398 2043 dbSNP
rs376746654 2056 dbSNP
rs992507831 2064 dbSNP
rs578224862 2066 dbSNP
rs1339242786 2067 dbSNP
rs138344988 2069 dbSNP
rs991097242 2074 dbSNP
rs558487334 2077 dbSNP
rs908145364 2080 dbSNP
rs1489938410 2091 dbSNP
rs1221982494 2093 dbSNP
rs183961894 2098 dbSNP
rs551139329 2102 dbSNP
rs1190679987 2107 dbSNP
rs1372435600 2128 dbSNP
rs1016499994 2129 dbSNP
rs757487153 2135 dbSNP
rs1169201281 2141 dbSNP
rs1363140143 2142 dbSNP
rs1287962495 2146 dbSNP
rs570703499 2152 dbSNP
rs547311445 2153 dbSNP
rs1316601894 2160 dbSNP
rs1030865031 2163 dbSNP
rs1299980149 2171 dbSNP
rs1357408582 2172 dbSNP
rs150084680 2174 dbSNP
rs879627717 2180 dbSNP
rs900525228 2181 dbSNP
rs964737825 2182 dbSNP
rs1369888976 2183 dbSNP
rs1038998182 2186 dbSNP
rs1447561531 2195 dbSNP
rs1303829611 2197 dbSNP
rs553072548 2198 dbSNP
rs568107662 2203 dbSNP
rs1008914167 2204 dbSNP
rs1443506021 2210 dbSNP
rs548307865 2211 dbSNP
rs1386716597 2221 dbSNP
rs1160846070 2227 dbSNP
rs1454593740 2231 dbSNP
rs1157254636 2233 dbSNP
rs934504124 2238 dbSNP
rs928481918 2240 dbSNP
rs1377561212 2242 dbSNP
rs1381146211 2244 dbSNP
rs1031617088 2245 dbSNP
rs1315816141 2248 dbSNP
rs116532117 2251 dbSNP
rs1259966647 2254 dbSNP
rs535065115 2256 dbSNP
rs761114486 2266 dbSNP
rs1210309595 2267 dbSNP
rs1241214552 2273 dbSNP
rs973749856 2274 dbSNP
rs1044168165 2281 dbSNP
rs1257649588 2283 dbSNP
rs962330554 2292 dbSNP
rs909471076 2296 dbSNP
rs1013043903 2297 dbSNP
rs895573474 2300 dbSNP
rs552176873 2307 dbSNP
rs1217074544 2316 dbSNP
rs1057170537 2317 dbSNP
rs1030480737 2330 dbSNP
rs1404617177 2333 dbSNP
rs998038080 2341 dbSNP
rs1337524419 2346 dbSNP
rs1381388623 2356 dbSNP
rs1389705320 2372 dbSNP
rs776500200 2373 dbSNP
rs964838642 2385 dbSNP
rs1017620291 2386 dbSNP
rs532887066 2390 dbSNP
rs939718619 2395 dbSNP
rs560826669 2398 dbSNP
rs113197352 2401 dbSNP
rs1053002279 2405 dbSNP
rs1204200006 2416 dbSNP
rs1257292083 2428 dbSNP
rs1479383122 2442 dbSNP
rs192734799 2453 dbSNP
rs907056259 2456 dbSNP
rs1218038600 2482 dbSNP
rs1473364135 2486 dbSNP
rs1184857462 2495 dbSNP
rs1427612244 2496 dbSNP
rs1480418525 2498 dbSNP
rs768112929 2499 dbSNP
rs1177461186 2507 dbSNP
rs1361357789 2512 dbSNP
rs1338750213 2515 dbSNP
rs1297615932 2516 dbSNP
rs759185789 2519 dbSNP
rs920800547 2530 dbSNP
rs1382978691 2532 dbSNP
rs1281203370 2546 dbSNP
rs1344604641 2553 dbSNP
rs113739028 2554 dbSNP
rs1303330785 2555 dbSNP
rs1305625386 2559 dbSNP
rs1251365585 2561 dbSNP
rs1301429872 2562 dbSNP
rs142248152 2563 dbSNP
rs965129442 2580 dbSNP
rs1219758630 2584 dbSNP
rs1267683163 2596 dbSNP
rs911999627 2603 dbSNP
rs867775465 2614 dbSNP
rs1192082594 2616 dbSNP
rs544311322 2619 dbSNP
rs1427254494 2624 dbSNP
rs956056394 2628 dbSNP
rs1390846985 2630 dbSNP
rs549606334 2632 dbSNP
rs1031587526 2641 dbSNP
rs1301561910 2644 dbSNP
rs915665005 2650 dbSNP
rs1405330749 2652 dbSNP
rs1476518165 2661 dbSNP
rs190252695 2665 dbSNP
rs1000155766 2671 dbSNP
rs748365931 2672 dbSNP
rs1295723311 2677 dbSNP
rs1193522038 2679 dbSNP
rs1441478608 2682 dbSNP
rs1038090448 2692 dbSNP
rs941039320 2695 dbSNP
rs1022768824 2696 dbSNP
rs1483549399 2705 dbSNP
rs1222857032 2709 dbSNP
rs908203860 2711 dbSNP
rs1257301852 2712 dbSNP
rs1198092181 2713 dbSNP
rs1316080783 2715 dbSNP
rs1249148502 2717 dbSNP
rs1012763379 2741 dbSNP
rs1451437394 2744 dbSNP
rs558556438 2746 dbSNP
rs1280167851 2750 dbSNP
rs983726918 2752 dbSNP
rs773988728 2756 dbSNP
rs1056903612 2764 dbSNP
rs950982909 2768 dbSNP
rs923489949 2776 dbSNP
rs1004272697 2781 dbSNP
rs1340073714 2787 dbSNP
rs1321163815 2791 dbSNP
rs976296054 2795 dbSNP
rs770507216 2797 dbSNP
rs1449843515 2804 dbSNP
rs1398118581 2809 dbSNP
rs965202891 2817 dbSNP
rs1407481559 2818 dbSNP
rs886808650 2820 dbSNP
rs1315541311 2823 dbSNP
rs544985932 2832 dbSNP
rs1047963303 2835 dbSNP
rs1011611110 2841 dbSNP
rs1466633482 2842 dbSNP
rs1401928218 2853 dbSNP
rs577102546 2854 dbSNP
rs1031616443 2855 dbSNP
rs1167954667 2857 dbSNP
rs1472287860 2864 dbSNP
rs1399908520 2867 dbSNP
rs1405999701 2867 dbSNP
rs762603814 2869 dbSNP
rs999209682 2874 dbSNP
rs1436347471 2879 dbSNP
rs1390833423 2890 dbSNP
rs1468156403 2891 dbSNP
rs1340520009 2905 dbSNP
rs554029045 2906 dbSNP
rs1024601222 2919 dbSNP
rs185779048 2920 dbSNP
rs894303671 2921 dbSNP
rs1039589612 2922 dbSNP
rs533191710 2933 dbSNP
rs1263019189 2942 dbSNP
rs1443095619 2959 dbSNP
rs886802792 2961 dbSNP
rs769584779 2962 dbSNP
rs1046739869 2973 dbSNP
rs1182710001 2977 dbSNP
rs1413876511 2978 dbSNP
rs933628740 2978 dbSNP
rs554768289 2980 dbSNP
rs1196744874 2981 dbSNP
rs537962084 2987 dbSNP
rs911950791 2991 dbSNP
rs976707532 3005 dbSNP
rs987609638 3006 dbSNP
rs375101400 3013 dbSNP
rs1196406399 3031 dbSNP
rs568953189 3034 dbSNP
rs1289412831 3047 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000369022.2 | 3UTR | UCAAGUUUUCAAAACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000369022.2 | 3UTR | UCAAGUUUUCAAAACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
152 hsa-miR-4476 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT065631 CLIC4 chloride intracellular channel 4 2 2
MIRT076187 GID4 GID complex subunit 4 homolog 2 4
MIRT086304 HOXD8 homeobox D8 2 6
MIRT110644 ARID5B AT-rich interaction domain 5B 2 2
MIRT144337 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT196634 TAOK1 TAO kinase 1 2 6
MIRT227655 SET SET nuclear proto-oncogene 2 2
MIRT263546 PPIF peptidylprolyl isomerase F 2 4
MIRT266189 TXNIP thioredoxin interacting protein 2 4
MIRT266815 SLC25A44 solute carrier family 25 member 44 2 2
MIRT285538 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT295094 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT300906 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT304110 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 6
MIRT314891 RGMB repulsive guidance molecule family member b 2 2
MIRT364225 ANP32B acidic nuclear phosphoprotein 32 family member B 2 2
MIRT366237 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405440 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT443613 OR2D2 olfactory receptor family 2 subfamily D member 2 2 2
MIRT445947 SCML4 Scm polycomb group protein like 4 2 2
MIRT445957 MLLT11 MLLT11, transcription factor 7 cofactor 2 2
MIRT445970 IKZF5 IKAROS family zinc finger 5 2 2
MIRT448066 MMP15 matrix metallopeptidase 15 2 2
MIRT449498 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT450831 IFFO1 intermediate filament family orphan 1 2 2
MIRT451270 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT451318 LGALS3BP galectin 3 binding protein 2 2
MIRT451403 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT451941 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452028 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452503 HMGXB3 HMG-box containing 3 2 2
MIRT453852 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454523 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT455402 PLA2G2F phospholipase A2 group IIF 2 2
MIRT455442 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT456983 MANEA mannosidase endo-alpha 2 2
MIRT457610 IDS iduronate 2-sulfatase 2 2
MIRT458319 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458756 CES2 carboxylesterase 2 2 2
MIRT458960 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460403 GPHA2 glycoprotein hormone alpha 2 2 2
MIRT460632 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461760 DDX11 DEAD/H-box helicase 11 2 2
MIRT461924 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT461977 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462271 TPI1 triosephosphate isomerase 1 2 2
MIRT462304 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT462725 SEMA4G semaphorin 4G 2 2
MIRT463414 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463525 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT464089 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464623 UBE4B ubiquitination factor E4B 2 2
MIRT465030 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465562 TOB2 transducer of ERBB2, 2 2 2
MIRT465890 TMEM43 transmembrane protein 43 2 2
MIRT466428 TFAP2A transcription factor AP-2 alpha 2 8
MIRT466593 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467623 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468511 SESN2 sestrin 2 2 2
MIRT468649 SEH1L SEH1 like nucleoporin 2 2
MIRT468737 SDC4 syndecan 4 2 2
MIRT468752 SDC2 syndecan 2 2 2
MIRT469182 RNF111 ring finger protein 111 2 2
MIRT469476 REEP5 receptor accessory protein 5 2 2
MIRT472078 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT472093 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT472194 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT472453 NAV2 neuron navigator 2 2 6
MIRT474493 KLHDC8B kelch domain containing 8B 2 2
MIRT475174 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475350 IFNLR1 interferon lambda receptor 1 2 2
MIRT476474 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477094 FAM168A family with sequence similarity 168 member A 2 2
MIRT477179 F3 coagulation factor III, tissue factor 2 6
MIRT478026 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT479587 CDC42SE1 CDC42 small effector 1 2 2
MIRT480117 CALR calreticulin 2 2
MIRT480465 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT480803 BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 2 6
MIRT481076 B4GALT1 beta-1,4-galactosyltransferase 1 2 2
MIRT482576 ABHD2 abhydrolase domain containing 2 2 2
MIRT482690 NXN nucleoredoxin 2 4
MIRT483599 SLC26A9 solute carrier family 26 member 9 2 2
MIRT485011 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT488051 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488067 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488176 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488859 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489074 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT489181 ANKRD45 ankyrin repeat domain 45 2 2
MIRT489981 DDB1 damage specific DNA binding protein 1 2 2
MIRT490225 WRN Werner syndrome RecQ like helicase 2 2
MIRT491084 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT491540 HDAC5 histone deacetylase 5 2 2
MIRT492540 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT499034 MAG myelin associated glycoprotein 2 2
MIRT499420 PLCG2 phospholipase C gamma 2 2 4
MIRT499820 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT500046 SDE2 SDE2 telomere maintenance homolog 2 6
MIRT500844 SYPL1 synaptophysin like 1 2 4
MIRT504518 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT505622 SLC25A37 solute carrier family 25 member 37 2 2
MIRT509134 STK4 serine/threonine kinase 4 2 2
MIRT509219 BUB3 BUB3, mitotic checkpoint protein 2 4
MIRT510752 SLC7A1 solute carrier family 7 member 1 2 2
MIRT512115 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT512317 ACTR2 ARP2 actin related protein 2 homolog 2 6
MIRT517395 BGN biglycan 2 4
MIRT518412 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 4
MIRT521362 RPL35A ribosomal protein L35a 2 2
MIRT525072 FRK fyn related Src family tyrosine kinase 2 2
MIRT525800 SOD2 superoxide dismutase 2 2 2
MIRT530430 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT541467 AURKA aurora kinase A 2 2
MIRT544303 TSPYL1 TSPY like 1 2 2
MIRT546415 SPRED3 sprouty related EVH1 domain containing 3 2 2
MIRT546582 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548764 CNN3 calponin 3 2 2
MIRT549809 KIAA0391 KIAA0391 2 2
MIRT550611 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT552227 FIG4 FIG4 phosphoinositide 5-phosphatase 2 4
MIRT554008 SPTLC1 serine palmitoyltransferase long chain base subunit 1 2 2
MIRT554116 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT555100 PURB purine rich element binding protein B 2 2
MIRT560290 HRH2 histamine receptor H2 2 2
MIRT560381 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT560800 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT560978 IWS1 IWS1, SUPT6H interacting protein 2 2
MIRT561161 BCL2L12 BCL2 like 12 2 2
MIRT562389 EN2 engrailed homeobox 2 2 2
MIRT562482 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT567784 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568831 TRIM67 tripartite motif containing 67 2 2
MIRT569555 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT572382 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575792 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT610505 CTBS chitobiase 2 4
MIRT616605 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT621780 TMEM87B transmembrane protein 87B 2 2
MIRT634217 TMEM192 transmembrane protein 192 2 2
MIRT639651 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT642500 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT643217 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT674822 KCNJ10 potassium voltage-gated channel subfamily J member 10 2 2
MIRT697356 ZNF426 zinc finger protein 426 2 2
MIRT704675 CHTOP chromatin target of PRMT1 2 2
MIRT708704 TFDP2 transcription factor Dp-2 2 2
MIRT709660 DFFB DNA fragmentation factor subunit beta 2 2
MIRT711280 SDR9C7 short chain dehydrogenase/reductase family 9C member 7 2 2
MIRT713733 SUCO SUN domain containing ossification factor 2 2
MIRT715006 TSPAN11 tetraspanin 11 2 2
MIRT718400 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4476 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4476 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-mir-4476 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-4476 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4476 Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-4476 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4476 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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