miRTarBase - #MIRT446237


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pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FZD6   
Synonyms FZ-6, FZ6, HFZ6, NDNC10
Description frizzled class receptor 6
Transcript NM_001164615   
Other Transcripts NM_001164616 , NM_003506   
Expression
Putative miRNA Targets on FZD6
3'UTR of FZD6
(miRNA target sites are highlighted)		 
>FZD6|NM_001164615|3'UTR
   1 AGAACATTTTCTCTCGTTACTCAGAAGCAAATTTGTGTTACACTGGAAGTGACCTATGCACTGTTTTGTAAGAATCACTG
  81 TTACATTCTTCTTTTGCACTTAAAGTTGCATTGCCTACTGTTATACTGGAAAAAATAGAGTTCAAGAATAATATGACTCA
 161 TTTCACACAAAGGTTAATGACAACAATATACCTGAAAACAGAAATGTGCAGGTTAATAATATTTTTTTAATAGTGTGGGA
 241 GGACAGAGTTAGAGGAATCTTCCTTTTCTATTTATGAAGATTCTACTCTTGGTAAGAGTATTTTAAGATGTACTATGCTA
 321 TTTTACTTTTTTGATATAAAATCAAGATATTTCTTTGCTGAAGTATTTAAATCTTATCCTTGTATCTTTTTATACATATT
 401 TGAAAATAAGCTTATATGTATTTGAACTTTTTTGAAATCCTATTCAAGTATTTTTATCATGCTATTGTGATATTTTAGCA
 481 CTTTGGTAGCTTTTACACTGAATTTCTAAGAAAATTGTAAAATAGTCTTCTTTTATACTGTAAAAAAAGATATACCAAAA
 561 AGTCTTATAATAGGAATTTAACTTTAAAAACCCACTTATTGATACCTTACCATCTAAAATGTGTGATTTTTATAGTCTCG
 641 TTTTAGGAATTTCACAGATCTAAATTATGTAACTGAAATAAGGTGCTTACTCAAAGAGTGTCCACTATTGATTGTATTAT
 721 GCTGCTCACTGATCCTTCTGCATATTTAAAATAAAATGTCCTAAAGGGTTAGTAGACAAAATGTTAGTCTTTTGTATATT
 801 AGGCCAAGTGCAATTGACTTCCCTTTTTTAATGTTTCATGACCACCCATTGATTGTATTATAACCACTTACAGTTGCTTA
 881 TATTTTTTGTTTTAACTTTTGTTTTTTAACATTTAGAATATTACATTTTGTATTATACAGTACCTTTCTCAGACATTTTG
 961 TAGAATTCATTTCGGCAGCTCACTAGGATTTTGCTGAACATTAAAAAGTGTGATAGCGATATTAGTGCCAATCAAATGGA
1041 AAAAAGGTAGTTTTAATAAACAAGACACAACGTTTTTATACAACATACTTTAAAATATTAAGGAGTTTTCTTAATTTTGT
1121 TTCCTATTAAGTATTATTCTTTGGGCAAGATTTTCTGATGCTTTTGATTTTCTCTCAATTTAGCATTTGCTTTTGGTTTT
1201 TTTCTCTATTTAGCATTCTGTTAAGGCACAAAAACTATGTACTGTATGGGAAATGTTGTAAATATTACCTTTTCCACATT
1281 TTAAACAGACAACTTTGAATACAAAAACTTTGTTTTGTGTGATCTTTTCATTAATAAAATTATCTTTGTATAAGAAAAAA
1361 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgaCAAGGACGACUu 5'
              | |::|||||| 
Target 5' ctagGATTTTGCTGAa 3'
 983 - 998 132.00 -10.10
2 
miRNA  3' ucgacAAG-GACGACUu 5'
               ||| :|||||| 
Target 5' gatatTTCTTTGCTGAa 3'
 346 - 362 131.00 -8.90
3 
miRNA  3' ucGACA----AGGACGACUu 5'
            :|||    | ||||| | 
Target 5' gaTTGTATTATGCTGCTCAc 3'
 710 - 729 112.00 -6.84
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31532865 11 COSMIC
COSN30162732 14 COSMIC
COSN30165907 14 COSMIC
COSN26976932 23 COSMIC
COSN30538389 72 COSMIC
COSN17748687 89 COSMIC
COSN31558759 170 COSMIC
COSN30115185 187 COSMIC
COSN20105763 206 COSMIC
COSN27883597 415 COSMIC
COSN22187457 572 COSMIC
COSN24896780 659 COSMIC
COSN32057825 884 COSMIC
COSN29044457 1055 COSMIC
COSN21623381 1072 COSMIC
COSN17591425 1074 COSMIC
COSN28670831 1102 COSMIC
COSN26561826 1168 COSMIC
COSN5668764 1222 COSMIC
COSN31548689 1308 COSMIC
COSN21123903 1324 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771707817 1 dbSNP
rs774893848 4 dbSNP
rs746461796 6 dbSNP
rs762772045 7 dbSNP
rs772994829 10 dbSNP
rs375233715 16 dbSNP
rs202151037 17 dbSNP
rs745515674 21 dbSNP
rs200202095 23 dbSNP
rs200403554 25 dbSNP
rs767708228 36 dbSNP
rs752732617 43 dbSNP
rs375750148 44 dbSNP
rs1390776903 45 dbSNP
rs1164501314 50 dbSNP
rs1459849574 55 dbSNP
rs1367299383 56 dbSNP
rs910955567 57 dbSNP
rs1478378328 61 dbSNP
rs1265578240 64 dbSNP
rs1191714488 67 dbSNP
rs775079407 76 dbSNP
rs1158430924 83 dbSNP
rs1211727466 84 dbSNP
rs1361553343 85 dbSNP
rs2934725 86 dbSNP
rs1299621945 89 dbSNP
rs970247879 101 dbSNP
rs1226157251 102 dbSNP
rs1331342054 103 dbSNP
rs1435160261 104 dbSNP
rs1384643717 106 dbSNP
rs980323449 110 dbSNP
rs1392883634 118 dbSNP
rs1274883789 119 dbSNP
rs922727017 124 dbSNP
rs765805800 125 dbSNP
rs1166518560 136 dbSNP
rs1475174470 137 dbSNP
rs773807060 162 dbSNP
rs1201083977 169 dbSNP
rs1431551303 170 dbSNP
rs768464864 185 dbSNP
rs35421828 202 dbSNP
rs796231490 202 dbSNP
rs763463112 203 dbSNP
rs202183884 206 dbSNP
rs550526662 213 dbSNP
rs766822353 223 dbSNP
rs893840152 244 dbSNP
rs1010847488 248 dbSNP
rs1345282590 252 dbSNP
rs984051667 270 dbSNP
rs190945010 271 dbSNP
rs1230412862 272 dbSNP
rs907614162 298 dbSNP
rs1369543930 300 dbSNP
rs1309390274 307 dbSNP
rs1045582849 311 dbSNP
rs1326120997 332 dbSNP
rs1403098424 336 dbSNP
rs1288019235 339 dbSNP
rs944488552 342 dbSNP
rs1409818865 343 dbSNP
rs1403141086 348 dbSNP
rs751902079 349 dbSNP
rs1040006453 354 dbSNP
rs905297334 358 dbSNP
rs1248468032 379 dbSNP
rs1179354230 381 dbSNP
rs1441453598 385 dbSNP
rs1438447006 409 dbSNP
rs1236355893 413 dbSNP
rs1004009565 420 dbSNP
rs900172400 425 dbSNP
rs931861615 441 dbSNP
rs755218973 442 dbSNP
rs1280504260 444 dbSNP
rs529787313 446 dbSNP
rs13273192 454 dbSNP
rs1346707039 458 dbSNP
rs566177819 461 dbSNP
rs999347514 466 dbSNP
rs1379754537 471 dbSNP
rs1278336752 472 dbSNP
rs960105698 480 dbSNP
rs1052734716 492 dbSNP
rs1404324410 500 dbSNP
rs1323662604 502 dbSNP
rs1433032434 519 dbSNP
rs1375132202 524 dbSNP
rs868069211 529 dbSNP
rs1159326309 536 dbSNP
rs1332307634 537 dbSNP
rs533546531 542 dbSNP
rs1308412762 543 dbSNP
rs983806856 555 dbSNP
rs567339455 557 dbSNP
rs1185545894 567 dbSNP
rs963835877 568 dbSNP
rs1355924623 587 dbSNP
rs1024268610 592 dbSNP
rs535316523 593 dbSNP
rs1350927706 602 dbSNP
rs1001520161 605 dbSNP
rs1357690412 612 dbSNP
rs147114928 612 dbSNP
rs1286310749 613 dbSNP
rs1456477348 614 dbSNP
rs1198627181 616 dbSNP
rs1239347824 621 dbSNP
rs1402108934 623 dbSNP
rs1442045688 626 dbSNP
rs922832875 632 dbSNP
rs570823999 641 dbSNP
rs983630462 642 dbSNP
rs538405054 646 dbSNP
rs1415942543 672 dbSNP
rs908044261 675 dbSNP
rs1474780290 688 dbSNP
rs965785669 692 dbSNP
rs1423866886 698 dbSNP
rs1052662948 700 dbSNP
rs976257128 709 dbSNP
rs1484692445 712 dbSNP
rs1185873472 715 dbSNP
rs921568266 716 dbSNP
rs931622687 727 dbSNP
rs1221740080 729 dbSNP
rs965219331 736 dbSNP
rs1368201862 740 dbSNP
rs1472295400 741 dbSNP
rs1043435776 744 dbSNP
rs925188304 754 dbSNP
rs915477348 763 dbSNP
rs1463626497 765 dbSNP
rs1334562340 767 dbSNP
rs946948227 769 dbSNP
rs1220621206 773 dbSNP
rs1360145853 774 dbSNP
rs1045087955 776 dbSNP
rs905161064 793 dbSNP
rs935277362 796 dbSNP
rs1052239513 798 dbSNP
rs1310383000 800 dbSNP
rs1339648182 801 dbSNP
rs756095977 804 dbSNP
rs1323862466 812 dbSNP
rs1245854135 817 dbSNP
rs1400706841 821 dbSNP
rs1286158299 825 dbSNP
rs1316246248 833 dbSNP
rs1426355529 835 dbSNP
rs556506602 847 dbSNP
rs1418438150 849 dbSNP
rs1191239268 862 dbSNP
rs1478754993 871 dbSNP
rs1250627087 873 dbSNP
rs1468434623 879 dbSNP
rs1259037341 882 dbSNP
rs1207131380 883 dbSNP
rs7827146 884 dbSNP
rs1295174108 899 dbSNP
rs895687169 906 dbSNP
rs993989464 912 dbSNP
rs1025458388 918 dbSNP
rs1199234004 921 dbSNP
rs79043564 922 dbSNP
rs1266018961 927 dbSNP
rs1005847263 934 dbSNP
rs1460311381 937 dbSNP
rs757109658 947 dbSNP
rs1017942388 949 dbSNP
rs1443330071 956 dbSNP
rs768441390 959 dbSNP
rs1045781451 961 dbSNP
rs905982766 968 dbSNP
rs1189990470 972 dbSNP
rs1001490410 973 dbSNP
rs184082629 975 dbSNP
rs572419216 976 dbSNP
rs1029812384 978 dbSNP
rs956890732 980 dbSNP
rs1479890739 981 dbSNP
rs952296491 982 dbSNP
rs1251127040 998 dbSNP
rs186924860 1002 dbSNP
rs1423701306 1013 dbSNP
rs915382635 1018 dbSNP
rs778777161 1019 dbSNP
rs76714224 1020 dbSNP
rs1377514935 1021 dbSNP
rs1309125265 1026 dbSNP
rs1389630220 1028 dbSNP
rs976305760 1031 dbSNP
rs1300976804 1034 dbSNP
rs1401296016 1035 dbSNP
rs1396416100 1039 dbSNP
rs1335898440 1040 dbSNP
rs1338724240 1041 dbSNP
rs1372297369 1041 dbSNP
rs1218185847 1049 dbSNP
rs2687355 1054 dbSNP
rs1373294496 1056 dbSNP
rs771760919 1068 dbSNP
rs939340612 1068 dbSNP
rs544382326 1073 dbSNP
rs897894611 1074 dbSNP
rs191610713 1076 dbSNP
rs1250173042 1078 dbSNP
rs1346276667 1090 dbSNP
rs1202548005 1094 dbSNP
rs1058130 1102 dbSNP
rs1487135833 1106 dbSNP
rs1255724796 1109 dbSNP
rs1192472063 1115 dbSNP
rs1046938550 1119 dbSNP
rs1263320256 1121 dbSNP
rs888241477 1128 dbSNP
rs1316287644 1132 dbSNP
rs771844178 1133 dbSNP
rs1173286021 1135 dbSNP
rs1005506493 1136 dbSNP
rs529794479 1141 dbSNP
rs1018598874 1146 dbSNP
rs899524179 1147 dbSNP
rs1400248133 1148 dbSNP
rs1466430767 1151 dbSNP
rs1286615311 1176 dbSNP
rs1175298083 1194 dbSNP
rs935221220 1196 dbSNP
rs183064316 1198 dbSNP
rs1399702900 1199 dbSNP
rs143515079 1208 dbSNP
rs956470244 1212 dbSNP
rs917870942 1227 dbSNP
rs187081989 1230 dbSNP
rs1187447834 1231 dbSNP
rs746553277 1241 dbSNP
rs968620326 1243 dbSNP
rs1332192574 1246 dbSNP
rs1236048931 1255 dbSNP
rs1485498092 1257 dbSNP
rs905948665 1271 dbSNP
rs768030117 1289 dbSNP
rs1265999042 1292 dbSNP
rs1234877970 1302 dbSNP
rs981081323 1310 dbSNP
rs1215504424 1319 dbSNP
rs926856315 1326 dbSNP
rs1218789314 1332 dbSNP
rs527259038 1335 dbSNP
rs1327844788 1339 dbSNP
rs1292818825 1350 dbSNP
rs1384845453 1352 dbSNP
rs191837768 1355 dbSNP
rs1463506628 1356 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgacAAG-GACGACuu 5'
               ||| :|||||  
Target 5' gauauUUCUUUGCUG-- 3'
 		5 - 19
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001164616 | 3UTR | UGUUUUUUAACAUUUAGAAUAUUACAUUUUGUAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_003506 | 3UTR | UAACAUUUAGAAUAUUACAUUUUGUAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003506 | 3UTR | AACAUUUAGAAUAUUACAUUUUGUAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001164615 | 3UTR | UUAGAAUAUUACAUUUUGUAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_003506 | 3UTR | UAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001164615 | 3UTR | UUUAGAAUAUUACAUUUUGUAUUAUACAGUACCUUUCUCAGACAUUUUGUAGAAUUCAUUUCGGCAGCUCACUAGGAUUUUGCUGAACAUUAAAAAGUGUGAUAGCGAUAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000358755.4 | 3UTR | UCAAGAUAUUUCUUUGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000358755.4 | 3UTR | UCAAGAUAUUUCUUUGCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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