pre-miRNA Information | |
---|---|
pre-miRNA | hsa-mir-1299 |
Genomic Coordinates | chr9: 40929010 - 40929092 |
Synonyms | MIRN1299, hsa-mir-1299, MIR1299 |
Description | Homo sapiens miR-1299 stem-loop |
Comment | None |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | |||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mature miRNA | hsa-miR-1299 | ||||||||||||||||||
Sequence | 62| UUCUGGAAUUCUGUGUGAGGGA |83 | ||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||
SNPs in miRNA |
|
||||||||||||||||||
Putative Targets |
miRNA Expression profile | |
---|---|
Human miRNA Tissue Atlas | |
miRNAs in Extracellular Vesicles |
|
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene Symbol | OCA2 | ||||||||||||||||||||
Synonyms | BEY, BEY1, BEY2, BOCA, D15S12, EYCL, EYCL2, EYCL3, HCL3, P, PED, SHEP1 | ||||||||||||||||||||
Description | OCA2 melanosomal transmembrane protein | ||||||||||||||||||||
Transcript | NM_000275 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on OCA2 | |||||||||||||||||||||
3'UTR of OCA2 (miRNA target sites are highlighted) |
>OCA2|NM_000275|3'UTR 1 TAGACATCCATCTATTGCTCGAAGACTAAAGGAAACTTCATCCATCACAACCCATTAGTCATAAAACTACCCTGACCCCA 81 CTGTTTGAAGAAGAAAAGGTGCTTACCCTGGAGATGCTACAGAGACACAGTGGAATAGACCTTGACACTAACACTCTAAT 161 TCAAGCGAATGTTGGAACACCATGACCTCCTCTGTGTGTCCTTTCTCCCCAAGGACAAAATGTAGAAAGATGTGAGATAA 241 CTTACTCAAGATTCCCCTCCAGAAAAATACGTATGTTTAAAAACCCTTCCTGCTATACATAGGAAAAGACACACATCCAC 321 CTAAAATTGACTGTACTGTTTAACTGTCAATTCTCCTGAGGCTAAACACAGTTTGTTTTTCTTGTAATCACTTTTCATGT 401 TAAAATAATCAGCATTCAAATTGTATGCTTTCTGAATATAGACTTTCTGGGAAAAGGTTTACTGCTCGTAAGGAAACATT 481 TTATGTATTAAAATAAACTGTTCCTTGATAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
---|---|---|---|---|---|---|---|
miRNA:Target | ---- | ||||||
Validation Method |
|
||||||
Conditions | BC-1 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine
PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine
... - Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe. |
||||||
miRNA-target interactions (Provided by authors) |
|
||||||
Article |
- Gottwein E; Corcoran DL; Mukherjee N; et al. - Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
|
CLIP-seq Support 1 for dataset GSM796037 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000353809.5 | 3UTR | UCAAGAUUCCCCUCCAGAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM796038 | |
---|---|
Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | BC-1 / 4-Thiouridine |
Location of target site | ENST00000353809.5 | 3UTR | UCAAGAUUCCCCUCCAGAA |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 22100165 / GSE32109 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MiRNA-Target Expression Profile (TCGA) | |||||||
---|---|---|---|---|---|---|---|
|
75 hsa-miR-1299 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT079552 | VAMP3 | vesicle associated membrane protein 3 | 2 | 2 | ||||||||
MIRT154885 | GNAS | GNAS complex locus | 2 | 4 | ||||||||
MIRT275056 | SESN2 | sestrin 2 | 2 | 4 | ||||||||
MIRT303051 | B3GNT2 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 | 2 | 4 | ||||||||
MIRT319158 | CCDC71L | coiled-coil domain containing 71 like | 2 | 2 | ||||||||
MIRT339620 | TMPO | thymopoietin | 2 | 2 | ||||||||
MIRT441961 | BACE2 | beta-site APP-cleaving enzyme 2 | 2 | 2 | ||||||||
MIRT445113 | DCAF4 | DDB1 and CUL4 associated factor 4 | 2 | 2 | ||||||||
MIRT445290 | CD274 | CD274 molecule | 2 | 2 | ||||||||
MIRT446037 | HMCN1 | hemicentin 1 | 2 | 2 | ||||||||
MIRT446162 | C8A | complement C8 alpha chain | 2 | 2 | ||||||||
MIRT446175 | ZNF37A | zinc finger protein 37A | 2 | 4 | ||||||||
MIRT446414 | OCA2 | OCA2 melanosomal transmembrane protein | 2 | 2 | ||||||||
MIRT446884 | TRIM25 | tripartite motif containing 25 | 2 | 2 | ||||||||
MIRT449789 | C1orf109 | chromosome 1 open reading frame 109 | 2 | 2 | ||||||||
MIRT450026 | EHD3 | EH domain containing 3 | 2 | 2 | ||||||||
MIRT450367 | ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif 5 | 2 | 2 | ||||||||
MIRT479739 | CCND1 | cyclin D1 | 2 | 2 | ||||||||
MIRT484809 | ZNFX1 | zinc finger NFX1-type containing 1 | 2 | 2 | ||||||||
MIRT485892 | ZFP36 | ZFP36 ring finger protein | 2 | 2 | ||||||||
MIRT486036 | UBBP4 | ubiquitin B pseudogene 4 | 2 | 2 | ||||||||
MIRT488295 | DHCR24 | 24-dehydrocholesterol reductase | 2 | 2 | ||||||||
MIRT497377 | METTL8 | methyltransferase like 8 | 2 | 2 | ||||||||
MIRT508219 | ZNF850 | zinc finger protein 850 | 2 | 6 | ||||||||
MIRT510923 | PRRX1 | paired related homeobox 1 | 2 | 4 | ||||||||
MIRT512661 | STEAP3 | STEAP3 metalloreductase | 2 | 2 | ||||||||
MIRT520031 | YOD1 | YOD1 deubiquitinase | 2 | 6 | ||||||||
MIRT528490 | AGTR2 | angiotensin II receptor type 2 | 2 | 2 | ||||||||
MIRT530083 | PAGR1 | PAXIP1 associated glutamate rich protein 1 | 2 | 4 | ||||||||
MIRT531086 | CCDC140 | coiled-coil domain containing 140 | 2 | 2 | ||||||||
MIRT535363 | PEX5L | peroxisomal biogenesis factor 5 like | 2 | 2 | ||||||||
MIRT535595 | NUDT21 | nudix hydrolase 21 | 2 | 2 | ||||||||
MIRT538613 | CCT5 | chaperonin containing TCP1 subunit 5 | 2 | 4 | ||||||||
MIRT539002 | AVL9 | AVL9 cell migration associated | 2 | 2 | ||||||||
MIRT545918 | ZC3H4 | zinc finger CCCH-type containing 4 | 2 | 2 | ||||||||
MIRT548482 | EEF2 | eukaryotic translation elongation factor 2 | 2 | 2 | ||||||||
MIRT555088 | PURB | purine rich element binding protein B | 2 | 2 | ||||||||
MIRT561421 | TRIB3 | tribbles pseudokinase 3 | 2 | 2 | ||||||||
MIRT564965 | WTAP | WT1 associated protein | 2 | 2 | ||||||||
MIRT571686 | RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 2 | 2 | ||||||||
MIRT574656 | KLHL15 | kelch like family member 15 | 2 | 2 | ||||||||
MIRT610037 | CNOT6 | CCR4-NOT transcription complex subunit 6 | 2 | 6 | ||||||||
MIRT612436 | SMOC2 | SPARC related modular calcium binding 2 | 2 | 2 | ||||||||
MIRT614349 | LOH12CR1 | BLOC-1 related complex subunit 5 | 2 | 2 | ||||||||
MIRT615304 | CCDC158 | coiled-coil domain containing 158 | 2 | 2 | ||||||||
MIRT615771 | FSD2 | fibronectin type III and SPRY domain containing 2 | 2 | 2 | ||||||||
MIRT615889 | MT1A | metallothionein 1A | 2 | 2 | ||||||||
MIRT619147 | ZNF326 | zinc finger protein 326 | 2 | 2 | ||||||||
MIRT622042 | SSBP2 | single stranded DNA binding protein 2 | 2 | 2 | ||||||||
MIRT637385 | R3HDM2 | R3H domain containing 2 | 2 | 2 | ||||||||
MIRT640739 | EPB41 | erythrocyte membrane protein band 4.1 | 2 | 2 | ||||||||
MIRT644418 | PIGS | phosphatidylinositol glycan anchor biosynthesis class S | 2 | 2 | ||||||||
MIRT647638 | FAIM2 | Fas apoptotic inhibitory molecule 2 | 2 | 2 | ||||||||
MIRT654305 | RBMS3 | RNA binding motif single stranded interacting protein 3 | 2 | 2 | ||||||||
MIRT654367 | RBM23 | RNA binding motif protein 23 | 2 | 2 | ||||||||
MIRT655944 | NDST1 | N-deacetylase and N-sulfotransferase 1 | 2 | 2 | ||||||||
MIRT655990 | MYRF | myelin regulatory factor | 2 | 2 | ||||||||
MIRT659692 | CD226 | CD226 molecule | 2 | 2 | ||||||||
MIRT665868 | TIAF1 | TGFB1-induced anti-apoptotic factor 1 | 2 | 2 | ||||||||
MIRT667317 | MYO18A | myosin XVIIIA | 2 | 2 | ||||||||
MIRT684312 | GTF3C4 | general transcription factor IIIC subunit 4 | 2 | 2 | ||||||||
MIRT694138 | CYP27C1 | cytochrome P450 family 27 subfamily C member 1 | 2 | 2 | ||||||||
MIRT698529 | TFRC | transferrin receptor | 2 | 2 | ||||||||
MIRT698834 | SSR2 | signal sequence receptor subunit 2 | 2 | 2 | ||||||||
MIRT700657 | PPP1R11 | protein phosphatase 1 regulatory inhibitor subunit 11 | 2 | 2 | ||||||||
MIRT705377 | ATP1B3 | ATPase Na+/K+ transporting subunit beta 3 | 2 | 2 | ||||||||
MIRT707314 | TMEM184B | transmembrane protein 184B | 2 | 2 | ||||||||
MIRT709027 | KBTBD13 | kelch repeat and BTB domain containing 13 | 2 | 2 | ||||||||
MIRT716032 | TMPRSS4 | transmembrane protease, serine 4 | 2 | 2 | ||||||||
MIRT718228 | LCE1A | late cornified envelope 1A | 2 | 2 | ||||||||
MIRT718475 | TMEM151A | transmembrane protein 151A | 2 | 2 | ||||||||
MIRT722333 | BEND6 | BEN domain containing 6 | 2 | 2 | ||||||||
MIRT734096 | TUG1 | taurine up-regulated 1 (non-protein coding) | 3 | 0 | ||||||||
MIRT734099 | NOTCH3 | notch 3 | 3 | 0 | ||||||||
MIRT755871 | LIF | LIF, interleukin 6 family cytokine | 4 | 1 |
miRNA-Drug Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|