miRTarBase - #MIRT446531


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pre-miRNA Information
pre-miRNA hsa-mir-6751   
Genomic Coordinates chr11: 65129916 - 65129978
Description Homo sapiens miR-6751 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6751-3p
Sequence 43| ACUGAGCCUCUCUCUCUCCAG |63
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM6795708 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749989972 2 dbSNP
rs1266150108 3 dbSNP
rs1488089412 6 dbSNP
rs1259846893 8 dbSNP
rs3802937 10 dbSNP
rs371083440 12 dbSNP
rs1264909843 13 dbSNP
rs751042478 14 dbSNP
rs757551063 19 dbSNP
Putative Targets

Gene Information
Gene Symbol OAS2   
Synonyms -
Description 2'-5'-oligoadenylate synthetase 2
Transcript NM_001032731   
Other Transcripts NM_002535 , NM_016817   
Expression
Putative miRNA Targets on OAS2
3'UTR of OAS2
(miRNA target sites are highlighted)		 
>OAS2|NM_001032731|3'UTR
   1 GCCATGAGTGGGATAGATACCACTGCTGCTTTAAAAAATGGGAGACCATAGACCCTCAGGAGAGAAGAATCCCTTCTACC
  81 CTGGACTCGCTCTCTTCTCTGGAACTAACTTCTCCCCCATACCCTGATTGTCTTTGGAGAAAATGTTCTGGATTCTAGAA
 161 TCTAAGGCAGAGCCTTTTAAGCCATACTGTACACATAAATCACCTGGAACCTTGTTAAAATGCAGATCCTGACTCAGGAG
 241 GTCTGAGTTAGAGCCCAGGATTTCATATTTCTAGCCAGCTCCATGATGAGCTGCTGGTCCGCAGATCATGCTTGCAGGTT
 321 TTGACCAGAGTCAGTGTTGGTTAGAGTAAGAGGATGAGGCAGACATCTGGGAAAAGTCCAGCTGGGGCAAGCATTTGAAG
 401 TCTGCCTTCCTACCAGGTCAAAATCAAGGCAACGACCTTCCATAGATAACTATCAAAGCTTGAGGGGGTGCCTTGAACCC
 481 AACTCCTAAATCCCTAAGACCTGCCCACCTCTTGTGTCTCCTGTCTCAGCAAACATTCCCACACTCTTGCATATTGTTAA
 561 AGTAACCTCTGCTTACCAGGCTTCTGGTTTAATAAAAGATGGCTAGAGTGACTCCATCTTAAAGCAAGTAGCTAGGCACT
 641 CAAAAGGAACCTACAGGCTTAATACTTGGGTCTGAAAATAGCCACAGTCTAAGCTGACCACCAATTATAATTGCAGAATA
 721 TTTAAGGCCATACAAAACATCTCCCACTAAGCCTACAAAATGTCCAGGTGTCCTAAAAGTTCAGCCCACTTAAAGGCAGC
 801 ATTAATGAGCAGGTTTAGGTTGAAGGATTAATGGTCATCAATACCACTGTTAAGAAGAAAATTCTTGGCCAAATTGAATT
 881 TAATGGAGTTTAACTGAGCAGACAATTCACAAATCTAGAAGCCTCCTGAGCCAGAGTAGGTTCAGAGAGTCTTGAACACA
 961 GCCACGTGGTGGAAGAAGATTTATGGACAGGAAAAGGAAAATGATGTACTGAAAATGAAAGTGAGGTACAGAAACAGCCA
1041 GACTGGTTATAGCTCAGCATTGGCCTTATTTGAACGAGATTTGAACAGTTGGCCACCTTTGATTGGCCGAAACTCAGTGA
1121 TTGGCACAAGAGTAGGTTGCAGTCTGTTTACACATCCTTTTAGGTTATAGTTCACCATGTACAGAGAAATTTTAGGCCAA
1201 ACTTAAAATATGTAAGGAGGCAGCTTTAGGCTAAACTTGATTTAACAGCACCAATACCCCCTACCTTTAGTGAGCACATC
1281 TGCACATTCCAATTTTAATGACAGCTCCTTAGAATTTCTTATCAACGAAGACACTAACAAAGAATGGCGCATTCCTCCTT
1361 CTCCTTTCTGAGGATGCCCTACCCTGTAACAAAGTCGTTTCTAATAAATTTGCTTCTTTCACCATAAAAAAAAAAAAAAA
1441 AAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacCUCUCUCUC-UCCGAGUCa 5'
             |||  |||| |||:|||| 
Target 5' cctGAGCCAGAGTAGGTTCAGa 3'
 925 - 946 150.00 -19.70
2 
miRNA  3' gaccucucuCUC-UCCGAGUCa 5'
                   ||| |||:|:|| 
Target 5' agcattaatGAGCAGGTTTAGg 3'
 798 - 819 120.00 -11.30
3 
miRNA  3' gaccucucucucucCGAGUCa 5'
                        |||||| 
Target 5' ccagactggttataGCTCAGc 3'
 1038 - 1058 120.00 -11.46
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30171864 30 COSMIC
COSN31612059 93 COSMIC
COSN27786973 205 COSMIC
COSN7608958 506 COSMIC
COSN22626272 571 COSMIC
COSN16727974 1323 COSMIC
COSN20828386 1394 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756465201 4 dbSNP
rs763794409 5 dbSNP
rs1299687574 10 dbSNP
rs753606879 13 dbSNP
rs757019478 15 dbSNP
rs778862069 21 dbSNP
rs745836782 22 dbSNP
rs372539409 25 dbSNP
rs748634799 30 dbSNP
rs781284494 30 dbSNP
rs950056330 30 dbSNP
rs1219100647 31 dbSNP
rs1248421976 32 dbSNP
rs1426016452 39 dbSNP
rs868302796 42 dbSNP
rs779588985 46 dbSNP
rs1181297008 50 dbSNP
rs932157003 54 dbSNP
rs1387495086 60 dbSNP
rs1255300045 74 dbSNP
rs1198520352 75 dbSNP
rs371565627 85 dbSNP
rs897900868 89 dbSNP
rs546997674 90 dbSNP
rs562089061 93 dbSNP
rs1197416020 94 dbSNP
rs929484568 95 dbSNP
rs1293766 99 dbSNP
rs1218924772 103 dbSNP
rs768803017 112 dbSNP
rs760951987 121 dbSNP
rs550807975 123 dbSNP
rs1273019901 126 dbSNP
rs1375193482 127 dbSNP
rs569377761 129 dbSNP
rs1366949957 138 dbSNP
rs539245280 140 dbSNP
rs1185082367 144 dbSNP
rs1425368479 162 dbSNP
rs1307936360 163 dbSNP
rs1197987809 174 dbSNP
rs995306628 184 dbSNP
rs1328803510 187 dbSNP
rs1049153069 189 dbSNP
rs181592620 190 dbSNP
rs894599451 193 dbSNP
rs137983953 195 dbSNP
rs1206887516 202 dbSNP
rs1259505258 211 dbSNP
rs1198728461 212 dbSNP
rs1275202523 215 dbSNP
rs1468971930 217 dbSNP
rs1221405557 224 dbSNP
rs1247385313 229 dbSNP
rs1012754217 252 dbSNP
rs1017818250 261 dbSNP
rs535338222 270 dbSNP
rs1024169999 276 dbSNP
rs971293096 280 dbSNP
rs1379774716 286 dbSNP
rs781496715 289 dbSNP
rs76632587 291 dbSNP
rs1404862723 294 dbSNP
rs967096723 301 dbSNP
rs1165263227 309 dbSNP
rs1293765 310 dbSNP
rs957060826 311 dbSNP
rs1177928268 315 dbSNP
rs1410743598 317 dbSNP
rs1471440300 318 dbSNP
rs1166650984 324 dbSNP
rs765762532 326 dbSNP
rs1264785944 336 dbSNP
rs990270323 339 dbSNP
rs921003291 348 dbSNP
rs12425514 354 dbSNP
rs986243287 356 dbSNP
rs573311290 367 dbSNP
rs1285677667 370 dbSNP
rs912089716 372 dbSNP
rs71465873 373 dbSNP
rs1321459565 376 dbSNP
rs140997978 383 dbSNP
rs1442629752 386 dbSNP
rs1310671324 388 dbSNP
rs1307243605 406 dbSNP
rs991831791 417 dbSNP
rs944924442 434 dbSNP
rs1036634295 435 dbSNP
rs555982469 441 dbSNP
rs930653802 444 dbSNP
rs919380289 445 dbSNP
rs1382050132 447 dbSNP
rs1049131933 468 dbSNP
rs894547232 469 dbSNP
rs1013036174 471 dbSNP
rs1045563511 486 dbSNP
rs907055463 493 dbSNP
rs1293764 496 dbSNP
rs570859835 500 dbSNP
rs1039707673 502 dbSNP
rs957548911 507 dbSNP
rs1205649084 508 dbSNP
rs1489499263 512 dbSNP
rs1287344940 519 dbSNP
rs1251457687 524 dbSNP
rs1342955194 533 dbSNP
rs546066861 536 dbSNP
rs767189892 544 dbSNP
rs1234073398 560 dbSNP
rs539901366 565 dbSNP
rs564699272 568 dbSNP
rs1050707983 571 dbSNP
rs1397875559 577 dbSNP
rs1362272414 589 dbSNP
rs573552278 594 dbSNP
rs1418161927 595 dbSNP
rs902819856 599 dbSNP
rs1472157980 609 dbSNP
rs1413773764 611 dbSNP
rs1422991471 619 dbSNP
rs1160997671 631 dbSNP
rs998563874 633 dbSNP
rs752296285 636 dbSNP
rs1421551717 638 dbSNP
rs1422437171 644 dbSNP
rs953783016 648 dbSNP
rs1191130054 651 dbSNP
rs1032738497 656 dbSNP
rs1243122162 687 dbSNP
rs755632253 695 dbSNP
rs1167891198 708 dbSNP
rs1281374486 712 dbSNP
rs556612055 717 dbSNP
rs1023328578 722 dbSNP
rs1317414780 730 dbSNP
rs1276516142 738 dbSNP
rs912036651 741 dbSNP
rs576474047 744 dbSNP
rs1270496862 751 dbSNP
rs981474656 752 dbSNP
rs1447044460 759 dbSNP
rs540945087 765 dbSNP
rs867123251 774 dbSNP
rs562025214 778 dbSNP
rs1357322497 793 dbSNP
rs74870925 799 dbSNP
rs371050859 800 dbSNP
rs1341339270 805 dbSNP
rs966239325 810 dbSNP
rs529276949 819 dbSNP
rs1168085579 820 dbSNP
rs1478558402 821 dbSNP
rs1282559159 823 dbSNP
rs1342083715 833 dbSNP
rs972676118 834 dbSNP
rs984893847 843 dbSNP
rs909271322 846 dbSNP
rs1229715883 847 dbSNP
rs1274580367 849 dbSNP
rs1184801948 852 dbSNP
rs1457359519 856 dbSNP
rs1256166175 865 dbSNP
rs763445801 873 dbSNP
rs186251741 875 dbSNP
rs1213518346 888 dbSNP
rs1039198309 889 dbSNP
rs923550583 898 dbSNP
rs1376771134 904 dbSNP
rs1257749399 910 dbSNP
rs933580192 941 dbSNP
rs1184772160 943 dbSNP
rs1376065667 945 dbSNP
rs1243279345 946 dbSNP
rs1466749025 953 dbSNP
rs930916198 956 dbSNP
rs1167832290 966 dbSNP
rs757195422 967 dbSNP
rs778882838 970 dbSNP
rs1403930650 972 dbSNP
rs1436325004 985 dbSNP
rs1042578842 990 dbSNP
rs2040807 997 dbSNP
rs758224297 1000 dbSNP
rs780440478 1003 dbSNP
rs1481025868 1007 dbSNP
rs1246325432 1017 dbSNP
rs747163879 1019 dbSNP
rs1319700571 1020 dbSNP
rs1293584599 1021 dbSNP
rs1403169324 1022 dbSNP
rs1307027022 1024 dbSNP
rs1448311258 1025 dbSNP
rs998447575 1026 dbSNP
rs1414189115 1027 dbSNP
rs1054641391 1029 dbSNP
rs1351273182 1049 dbSNP
rs1304082780 1051 dbSNP
rs555159670 1053 dbSNP
rs562822635 1061 dbSNP
rs774749038 1070 dbSNP
rs1378972036 1071 dbSNP
rs533492881 1076 dbSNP
rs768922651 1077 dbSNP
rs1424636742 1091 dbSNP
rs1189554575 1092 dbSNP
rs554551973 1099 dbSNP
rs892869417 1104 dbSNP
rs1222896080 1106 dbSNP
rs948762172 1109 dbSNP
rs1022789349 1110 dbSNP
rs1241166912 1113 dbSNP
rs1363708118 1122 dbSNP
rs1045854889 1125 dbSNP
rs1002795727 1131 dbSNP
rs1344754359 1138 dbSNP
rs1198316026 1147 dbSNP
rs1285939827 1150 dbSNP
rs906998860 1153 dbSNP
rs1303423801 1155 dbSNP
rs1399765416 1168 dbSNP
rs776636647 1171 dbSNP
rs1187432334 1173 dbSNP
rs1246095372 1175 dbSNP
rs1455579775 1185 dbSNP
rs1454703641 1198 dbSNP
rs1194027969 1212 dbSNP
rs984796976 1212 dbSNP
rs1173979254 1230 dbSNP
rs1376792353 1241 dbSNP
rs1053403231 1247 dbSNP
rs551131236 1255 dbSNP
rs1011478667 1258 dbSNP
rs144828759 1261 dbSNP
rs1486126860 1263 dbSNP
rs889468770 1280 dbSNP
rs1207377095 1285 dbSNP
rs975196575 1286 dbSNP
rs1007893702 1287 dbSNP
rs572688259 1297 dbSNP
rs961457785 1301 dbSNP
rs933466542 1303 dbSNP
rs148267407 1306 dbSNP
rs972239509 1327 dbSNP
rs548868256 1328 dbSNP
rs1379028714 1332 dbSNP
rs1302604905 1338 dbSNP
rs115427371 1339 dbSNP
rs924181011 1346 dbSNP
rs952299769 1349 dbSNP
rs141380561 1350 dbSNP
rs1426079240 1358 dbSNP
rs556158981 1358 dbSNP
rs948506146 1369 dbSNP
rs1044499479 1371 dbSNP
rs1428941805 1375 dbSNP
rs565512275 1377 dbSNP
rs915872934 1380 dbSNP
rs948706230 1381 dbSNP
rs770243736 1384 dbSNP
rs773730363 1397 dbSNP
rs1263147830 1398 dbSNP
rs1469424992 1404 dbSNP
rs1197479297 1408 dbSNP
rs928735549 1425 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000342315.4 | 3UTR | UCAAGCUCUCCAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000342315.4 | 3UTR | UCAAGCUCUCCAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
77 hsa-miR-6751-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130738 GATAD2B GATA zinc finger domain containing 2B 2 4
MIRT134924 CCND2 cyclin D2 2 2
MIRT273034 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT276645 KPNA3 karyopherin subunit alpha 3 2 6
MIRT446531 OAS2 2'-5'-oligoadenylate synthetase 2 2 2
MIRT456268 TDRKH tudor and KH domain containing 2 12
MIRT494454 BTG2 BTG anti-proliferation factor 2 2 2
MIRT494965 USP46 ubiquitin specific peptidase 46 2 2
MIRT496689 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT496697 RGS11 regulator of G protein signaling 11 2 2
MIRT504376 IRF4 interferon regulatory factor 4 2 6
MIRT510980 PFN2 profilin 2 2 6
MIRT512548 MFN2 mitofusin 2 2 6
MIRT513639 TP53INP2 tumor protein p53 inducible nuclear protein 2 2 2
MIRT514016 CAMSAP1 calmodulin regulated spectrin associated protein 1 2 4
MIRT514074 MTRNR2L6 MT-RNR2-like 6 2 2
MIRT515300 C15orf38-AP3S2 C15orf38-AP3S2 readthrough 2 4
MIRT517285 AP3S2 adaptor related protein complex 3 sigma 2 subunit 2 4
MIRT519075 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT520779 TCF23 transcription factor 23 2 2
MIRT522485 MFSD9 major facilitator superfamily domain containing 9 2 2
MIRT528856 PKP1 plakophilin 1 2 2
MIRT529081 PATE2 prostate and testis expressed 2 2 2
MIRT531209 PLA2G4D phospholipase A2 group IVD 2 2
MIRT533988 TAB3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 2 2
MIRT537024 GRIN2B glutamate ionotropic receptor NMDA type subunit 2B 2 2
MIRT537498 FAM168B family with sequence similarity 168 member B 2 2
MIRT553125 UBE2Z ubiquitin conjugating enzyme E2 Z 2 2
MIRT555591 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT556370 LUZP1 leucine zipper protein 1 2 2
MIRT569745 C2orf71 chromosome 2 open reading frame 71 2 2
MIRT570149 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT571243 FADS6 fatty acid desaturase 6 2 2
MIRT573065 TRIB1 tribbles pseudokinase 1 2 2
MIRT575533 Map4 microtubule-associated protein 4 2 2
MIRT575777 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT616558 ZNF512B zinc finger protein 512B 2 2
MIRT624851 ABI2 abl interactor 2 2 2
MIRT630078 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT631479 KLHL21 kelch like family member 21 2 2
MIRT632173 CCL22 C-C motif chemokine ligand 22 2 2
MIRT638397 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT641192 ISG20L2 interferon stimulated exonuclease gene 20 like 2 2 2
MIRT642562 TEX9 testis expressed 9 2 2
MIRT642935 KRTAP5-9 keratin associated protein 5-9 2 2
MIRT649703 ZNF175 zinc finger protein 175 2 2
MIRT650437 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT652113 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652273 TOMM20 translocase of outer mitochondrial membrane 20 2 2
MIRT655215 PFKM phosphofructokinase, muscle 2 2
MIRT682778 ZNF852 zinc finger protein 852 2 2
MIRT683001 MUC20 mucin 20, cell surface associated 2 2
MIRT684320 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT689435 CYB561 cytochrome b561 2 2
MIRT693847 ZNF107 zinc finger protein 107 2 2
MIRT696715 TAX1BP3 Tax1 binding protein 3 2 2
MIRT698597 TEX261 testis expressed 261 2 2
MIRT699973 RREB1 ras responsive element binding protein 1 2 2
MIRT703310 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT706796 RAI1 retinoic acid induced 1 2 2
MIRT709004 CD109 CD109 molecule 2 2
MIRT709181 TBC1D10B TBC1 domain family member 10B 2 2
MIRT709835 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT711627 CORO1C coronin 1C 2 2
MIRT712634 RNF103-CHMP3 RNF103-CHMP3 readthrough 2 2
MIRT713694 CYB5R4 cytochrome b5 reductase 4 2 2
MIRT713752 SLC9A8 solute carrier family 9 member A8 2 2
MIRT714908 CHMP3 charged multivesicular body protein 3 2 2
MIRT716371 CBLL1 Cbl proto-oncogene like 1 2 2
MIRT718303 XPOT exportin for tRNA 2 2
MIRT718713 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718740 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT719441 NPTX2 neuronal pentraxin 2 2 2
MIRT720896 OTUD4 OTU deubiquitinase 4 2 2
MIRT722448 RXFP4 relaxin/insulin like family peptide receptor 4 2 2
MIRT723882 VKORC1 vitamin K epoxide reductase complex subunit 1 2 2
MIRT724586 SYNJ2BP synaptojanin 2 binding protein 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6751 Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (A2780)
hsa-mir-6751 Triptolide 107985 NSC163062 sensitive Low Ovarian Cancer cell line (A2780)

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