miRTarBase - #MIRT446580


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pre-miRNA Information
pre-miRNA hsa-mir-3160-1   
Genomic Coordinates chr11: 46451805 - 46451889
Description Homo sapiens miR-3160-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-3160-2   
Genomic Coordinates chr11: 46451807 - 46451887
Description Homo sapiens miR-3160-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3160-3p
Sequence 54| AGAGCUGAGACUAGAAAGCCCA |75
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30582333 1 COSMIC
COSN1535547 3 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1396368683 1 dbSNP
rs1162409303 2 dbSNP
rs1404378453 12 dbSNP
rs1171960732 14 dbSNP
rs1324633375 16 dbSNP
rs1187765019 16 dbSNP
rs1300058326 19 dbSNP
rs1432898407 21 dbSNP
rs1011279103 22 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FPR2   
Synonyms ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH1, FPRH2, FPRL1, HM63, LXA4R
Description formyl peptide receptor 2
Transcript NM_001005738   
Other Transcripts NM_001462   
Expression
Putative miRNA Targets on FPR2
3'UTR of FPR2
(miRNA target sites are highlighted)		 
>FPR2|NM_001005738|3'UTR
   1 GGATGGGGTCAGGGATATTTTGAGTTCTGTTCATCCTACCCTAATGCCAGTTCCAGCTTCATCTACCCTTGAGTCATATT
  81 GAGGCATTCAAGGATGCACAGCTCAAGTATTTATTCAGGAAAAATGCTTTTGTGTCCCTGATTTGGGGCTAAGAAATAGA
 161 CAGTCAGGCTACTAAAATATTAGTGTTATTTTTTGTTTTTTGACTTCTGCCTATACCCTGGGGTAAGTGGAGTTGGGAAA
 241 TACAAGAAGAGAAAGACCAGTGGGGATTTGTAAGACTTAGATGAGATAGCGCATAATAAGGGGAAGACTTTAAAGTATAA
 321 AGTAAAATGTTTGCTGTAGGTTTTTTATAGCTATTAAAAAAAATCAGATTATGGAAGTTTTCTTCTATTTTTAGTTTGCT
 401 AAGAGTTTTCTGTTTCTTTTTCTTACATCATGAGTGGACTTTGCATTTTATCAAATGCATTTTCTACATGTATTAAGATG
 481 GTCATATTATTCTTCTTCTTTTATGTAAATCATTATAAATAATGTTCATTAAGTTCTGAATGTTAAACTACTCTTGAATT
 561 CCTGGAATAAACCACACTTAGTCCTGATGTACTTTAAATATTTATATCTCACAGGAGTTGGTTAGAATTTCTGTGTTTAT
 641 GTTTATATACTGTTATTTCACTTTTTCTACTATCCTTGCTAAGTTTTCATAGAAAATAAGGAACAAAGAGAAACTTGTAA
 721 TGGTCTCTGAAAAGGAATTGAGAAGTAATTCCTCTGATTCTGTTTTCTGGTGTTATATCTTTATTAAATATTCAGAAAAA
 801 TTCACCAGTGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acCCGAAAGAUC--A-GAGUCGAGa 5'
            ||| ||| ||  | | |||||| 
Target 5' gaGGCATTCAAGGATGCACAGCTCa 3'
 81 - 105 134.00 -15.00
2 
miRNA  3' acccgaAAGAUCAGAGUCGAGa 5'
                ||||| |:|:||:|: 
Target 5' gttttcTTCTATTTTTAGTTTg 3'
 377 - 398 120.00 -8.40
3 
miRNA  3' acccgAAAGAUCAGAGUCGAGa 5'
               |||: ||| || |:|| 
Target 5' ggataTTTTGAGT-TCTGTTCa 3'
 13 - 33 112.00 -8.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30182023 9 COSMIC
COSN26424000 13 COSMIC
COSN30473997 33 COSMIC
COSN30531079 33 COSMIC
COSN31508920 33 COSMIC
COSN15624127 36 COSMIC
COSN31573908 51 COSMIC
COSN30472156 57 COSMIC
COSN30131759 63 COSMIC
COSN28880902 85 COSMIC
COSN31496052 90 COSMIC
COSN15624128 93 COSMIC
COSN31525335 113 COSMIC
COSN30116031 125 COSMIC
COSN31558678 128 COSMIC
COSN31499844 132 COSMIC
COSN8606231 150 COSMIC
COSN29158795 161 COSMIC
COSN30143935 167 COSMIC
COSN30124082 176 COSMIC
COSN30139542 181 COSMIC
COSN30114398 184 COSMIC
COSN31540829 191 COSMIC
COSN30124687 259 COSMIC
COSN28748256 271 COSMIC
COSN8606232 292 COSMIC
COSN28732502 303 COSMIC
COSN19505505 312 COSMIC
COSN30136194 345 COSMIC
COSN30135308 357 COSMIC
COSN30117149 362 COSMIC
COSN25448363 364 COSMIC
COSN26635905 413 COSMIC
COSN15624129 423 COSMIC
COSN31548512 449 COSMIC
COSN23641816 453 COSMIC
COSN30129394 455 COSMIC
COSN30116817 476 COSMIC
COSN31547745 499 COSMIC
COSN24734074 530 COSMIC
COSN26555487 543 COSMIC
COSN30135376 575 COSMIC
COSN30131422 593 COSMIC
COSN30111797 637 COSMIC
COSN15624130 675 COSMIC
COSN31546520 714 COSMIC
COSN21792833 763 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs776964352 2 dbSNP
rs762388829 4 dbSNP
rs543606414 9 dbSNP
rs1159809735 16 dbSNP
rs773687110 22 dbSNP
rs555321111 30 dbSNP
rs201955289 31 dbSNP
rs368364964 33 dbSNP
rs1385713707 47 dbSNP
rs79685117 51 dbSNP
rs1201188897 53 dbSNP
rs1330474261 57 dbSNP
rs1054301459 69 dbSNP
rs1377353451 72 dbSNP
rs892859013 80 dbSNP
rs1393121100 84 dbSNP
rs1207561278 97 dbSNP
rs559201676 100 dbSNP
rs1486520764 108 dbSNP
rs1269394200 109 dbSNP
rs1208632557 113 dbSNP
rs527704200 115 dbSNP
rs1285548523 127 dbSNP
rs1027548574 128 dbSNP
rs887695684 143 dbSNP
rs1244916398 144 dbSNP
rs545760267 149 dbSNP
rs1004683634 189 dbSNP
rs564241817 214 dbSNP
rs1456614077 221 dbSNP
rs1386316623 223 dbSNP
rs59594213 228 dbSNP
rs34773942 235 dbSNP
rs1257885911 253 dbSNP
rs960733775 256 dbSNP
rs17695052 260 dbSNP
rs1002571711 263 dbSNP
rs1248080148 265 dbSNP
rs1197858056 267 dbSNP
rs1254722612 272 dbSNP
rs1423689771 288 dbSNP
rs1034997253 289 dbSNP
rs562175838 290 dbSNP
rs17695064 291 dbSNP
rs548129447 292 dbSNP
rs1027112555 294 dbSNP
rs1254548095 301 dbSNP
rs1229858073 302 dbSNP
rs951586858 304 dbSNP
rs1170217932 315 dbSNP
rs1297006467 318 dbSNP
rs935621422 324 dbSNP
rs376141356 335 dbSNP
rs1336015182 340 dbSNP
rs982822381 342 dbSNP
rs988267832 348 dbSNP
rs767534972 352 dbSNP
rs1170495960 356 dbSNP
rs912756068 356 dbSNP
rs965738265 357 dbSNP
rs1447060289 363 dbSNP
rs1239788592 366 dbSNP
rs753811439 373 dbSNP
rs761796518 380 dbSNP
rs566342250 386 dbSNP
rs539451252 394 dbSNP
rs1401473381 404 dbSNP
rs1442256741 406 dbSNP
rs551349167 431 dbSNP
rs551393264 438 dbSNP
rs921814305 444 dbSNP
rs921365696 445 dbSNP
rs1483519707 452 dbSNP
rs764954854 453 dbSNP
rs1337758185 468 dbSNP
rs1226274475 470 dbSNP
rs1361671172 471 dbSNP
rs1285941964 489 dbSNP
rs1245396389 490 dbSNP
rs1434410434 490 dbSNP
rs569631281 493 dbSNP
rs1308854239 507 dbSNP
rs989944633 517 dbSNP
rs569975765 539 dbSNP
rs536788032 542 dbSNP
rs1048432442 544 dbSNP
rs1427329713 556 dbSNP
rs945898995 559 dbSNP
rs1415304751 562 dbSNP
rs1041477208 564 dbSNP
rs1472777375 573 dbSNP
rs1367188738 578 dbSNP
rs906976220 590 dbSNP
rs938324080 595 dbSNP
rs1483550682 597 dbSNP
rs1251442984 599 dbSNP
rs1203262942 600 dbSNP
rs147462239 618 dbSNP
rs894685963 630 dbSNP
rs1259765684 631 dbSNP
rs1487355072 633 dbSNP
rs1282298248 643 dbSNP
rs187291482 647 dbSNP
rs1036184986 652 dbSNP
rs995711132 674 dbSNP
rs757996947 684 dbSNP
rs534484136 691 dbSNP
rs55794581 692 dbSNP
rs1004359620 697 dbSNP
rs535988451 701 dbSNP
rs1389216341 707 dbSNP
rs1161991729 715 dbSNP
rs375159239 718 dbSNP
rs145694009 723 dbSNP
rs975784746 725 dbSNP
rs1479145812 729 dbSNP
rs1247460008 730 dbSNP
rs1198268273 731 dbSNP
rs1449870869 732 dbSNP
rs1271258239 733 dbSNP
rs1210490013 736 dbSNP
rs1028328782 739 dbSNP
rs1329658903 745 dbSNP
rs956936720 747 dbSNP
rs1226296929 750 dbSNP
rs1369305723 754 dbSNP
rs958065932 759 dbSNP
rs990060698 766 dbSNP
rs763897836 767 dbSNP
rs1430501688 777 dbSNP
rs1328829547 779 dbSNP
rs544900620 781 dbSNP
rs967186410 802 dbSNP
rs1388494654 809 dbSNP
rs1466543708 811 dbSNP
rs1314664350 814 dbSNP
rs975987755 818 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000340023.6 | 3UTR | UCAAGUAUUUAUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000340023.6 | 3UTR | UCAAGUAUUUAUUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
Click to see details
118 hsa-miR-3160-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066658 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT075318 SF3B3 splicing factor 3b subunit 3 2 4
MIRT077083 EIF1 eukaryotic translation initiation factor 1 2 2
MIRT100381 HSPA1B heat shock protein family A (Hsp70) member 1B 2 6
MIRT135259 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT184913 ZNF268 zinc finger protein 268 2 2
MIRT218862 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT446580 FPR2 formyl peptide receptor 2 2 2
MIRT448834 FGD4 FYVE, RhoGEF and PH domain containing 4 2 2
MIRT449455 RNF13 ring finger protein 13 2 2
MIRT452284 CARD8 caspase recruitment domain family member 8 2 2
MIRT452628 FAM162A family with sequence similarity 162 member A 2 2
MIRT453454 GLG1 golgi glycoprotein 1 2 2
MIRT454188 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 6
MIRT454434 GTF2F1 general transcription factor IIF subunit 1 2 2
MIRT454575 NT5DC3 5'-nucleotidase domain containing 3 2 2
MIRT455555 TRAF1 TNF receptor associated factor 1 2 6
MIRT455841 MPL MPL proto-oncogene, thrombopoietin receptor 2 6
MIRT455969 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT456805 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT457320 DUSP19 dual specificity phosphatase 19 2 2
MIRT457366 POFUT2 protein O-fucosyltransferase 2 2 2
MIRT457684 ZNF587 zinc finger protein 587 2 2
MIRT458158 LYRM4 LYR motif containing 4 2 6
MIRT458641 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT459134 FADS6 fatty acid desaturase 6 2 2
MIRT459153 NARF nuclear prelamin A recognition factor 2 4
MIRT460460 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460974 STK17B serine/threonine kinase 17b 2 2
MIRT461439 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT461507 NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 2 2
MIRT462490 GSR glutathione-disulfide reductase 2 2
MIRT462638 PHF5A PHD finger protein 5A 2 2
MIRT463279 ZFX zinc finger protein, X-linked 2 2
MIRT463360 ZFAND4 zinc finger AN1-type containing 4 2 2
MIRT465777 TMOD3 tropomodulin 3 2 2
MIRT466143 TMEM120B transmembrane protein 120B 2 2
MIRT468401 SETD3 SET domain containing 3 2 2
MIRT468998 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT471574 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT472108 NME2 NME/NM23 nucleoside diphosphate kinase 2 2 2
MIRT472125 NME1-NME2 NME1-NME2 readthrough 2 2
MIRT473020 MRPS14 mitochondrial ribosomal protein S14 2 2
MIRT473083 MORN4 MORN repeat containing 4 2 2
MIRT475598 HMGB2 high mobility group box 2 2 4
MIRT475937 GXYLT2 glucoside xylosyltransferase 2 2 8
MIRT476117 GPR157 G protein-coupled receptor 157 2 2
MIRT476406 GDE1 glycerophosphodiester phosphodiesterase 1 2 2
MIRT478003 DNAL1 dynein axonemal light chain 1 2 2
MIRT487969 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489418 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491522 IL10RA interleukin 10 receptor subunit alpha 2 2
MIRT492673 PLEC plectin 2 2
MIRT493545 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT513085 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT514009 CECR2 CECR2, histone acetyl-lysine reader 2 4
MIRT516683 ZNF860 zinc finger protein 860 2 2
MIRT518392 ZNF250 zinc finger protein 250 2 2
MIRT522683 LUZP1 leucine zipper protein 1 2 6
MIRT524488 CEP97 centrosomal protein 97 2 2
MIRT527457 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT527705 IL17REL interleukin 17 receptor E like 2 2
MIRT531647 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT532381 UMPS uridine monophosphate synthetase 2 2
MIRT532588 MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 2 2
MIRT533555 TPM4 tropomyosin 4 2 2
MIRT548371 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 4
MIRT550250 PVR poliovirus receptor 2 2
MIRT552555 ZFP36L2 ZFP36 ring finger protein like 2 2 4
MIRT554113 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT554131 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT561344 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT561638 RUNX3 runt related transcription factor 3 2 2
MIRT566497 PBX2P1 PBX homeobox 2 pseudogene 1 2 2
MIRT570583 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572731 MCTS1 MCTS1, re-initiation and release factor 2 2
MIRT574041 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT575231 Fut1 fucosyltransferase 1 2 2
MIRT606811 BICD2 BICD cargo adaptor 2 2 2
MIRT621016 CLSTN3 calsyntenin 3 2 2
MIRT637852 PDCL3 phosducin like 3 2 2
MIRT640477 ZNF557 zinc finger protein 557 2 2
MIRT642827 LINC00346 long intergenic non-protein coding RNA 346 2 2
MIRT643887 IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2 2
MIRT664874 PCNXL2 pecanex homolog 2 2 2
MIRT680528 PRIM2 DNA primase subunit 2 2 2
MIRT680648 KIAA1456 KIAA1456 2 2
MIRT680807 ZNF578 zinc finger protein 578 2 2
MIRT680921 STX2 syntaxin 2 2 2
MIRT681112 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT681147 INTS7 integrator complex subunit 7 2 2
MIRT681966 TFCP2 transcription factor CP2 2 2
MIRT684316 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT684906 GSG2 histone H3 associated protein kinase 2 2
MIRT685499 MED16 mediator complex subunit 16 2 2
MIRT685929 MOCS3 molybdenum cofactor synthesis 3 2 2
MIRT686875 SLC25A32 solute carrier family 25 member 32 2 2
MIRT688204 FNIP1 folliculin interacting protein 1 2 2
MIRT688791 CCNB1 cyclin B1 2 2
MIRT689227 RPS19 ribosomal protein S19 2 2
MIRT690470 ZNF33A zinc finger protein 33A 2 2
MIRT691982 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT694006 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT694529 TRIM72 tripartite motif containing 72 2 2
MIRT695420 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT695784 HSD17B12 hydroxysteroid 17-beta dehydrogenase 12 2 2
MIRT697799 UBXN2A UBX domain protein 2A 2 2
MIRT698275 TMEM2 transmembrane protein 2 2 2
MIRT698317 TMEM136 transmembrane protein 136 2 2
MIRT699971 RREB1 ras responsive element binding protein 1 2 2
MIRT700717 PNO1 partner of NOB1 homolog 2 2
MIRT701721 MTMR12 myotubularin related protein 12 2 2
MIRT701879 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT702959 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT706178 ZNF716 zinc finger protein 716 2 2
MIRT706463 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT718154 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT718711 ANKRD18A ankyrin repeat domain 18A 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3160-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-3160-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-3160-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-3160-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3160-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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