miRTarBase - #MIRT446718


—
pre-miRNA Information
pre-miRNA hsa-mir-4540   
Genomic Coordinates chr9: 36864254 - 36864308
Description Homo sapiens miR-4540 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4540
Sequence 35| UUAGUCCUGCCUGUAGGUUUA |55
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs937122950 4 dbSNP
rs143699849 7 dbSNP
Putative Targets

Gene Information
Gene Symbol PSG3   
Synonyms -
Description pregnancy specific beta-1-glycoprotein 3
Transcript NM_021016   
Expression
Putative miRNA Targets on PSG3
3'UTR of PSG3
(miRNA target sites are highlighted)		 
>PSG3|NM_021016|3'UTR
   1 CAGCCGTGATGTCATTTCTGTATTTCAGGAAGACTGGCAGACAGTTGCTTTCATTCTTCCTCAAAGTATTTACCATCAGC
  81 TACAGTCCAAAATTGCTTTTTGTTCAAGGAGATTTATGAAAAGACTCTGACAAGGACTCTTGAATACAAGTTCCTGATAA
 161 CTTCAAGATCATACCACTGGACTAAGAACTTTCAAAATTTTAATGAACAGGCTGATACTTCATGAAATTCAAGACAAAGA
 241 AAAAAACCCAATTTTATTGGACTAAATAGTCAAAACAATGTTTTCATAATTTTCTATTTGAAAATGTGCTGATTCTTTGA
 321 ATGTTTTATTCTCCAGATTTATGCACTTTTTTTCTTCAGCAATTGGTAAAGTATACTTTTGTAAACAAAAATTGAAACAT
 401 TTGCTTTTGCTCCCTAAGTGCCCCAGAATTGGGAAACTATTCAGGAGTATTCATATGTTTATGGTAATAAAGTTATCTGC
 481 ACAAGTTCAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUGGA-UGUCCGUCCUGAuu 5'
            | :|| |||   ||||||  
Target 5' agACTCTGACA---AGGACTct 3'
 122 - 140 128.00 -10.60
2 
miRNA  3' auUUGGAUGUCCGUCCUGAUu 5'
            || |||:   ||||| || 
Target 5' ggAAACTAT--TCAGGAGTAt 3'
 432 - 450 123.00 -9.40
3 
miRNA  3' auuuggauguccguCCUGAUu 5'
                        |||||| 
Target 5' aagatcataccactGGACTAa 3'
 165 - 185 120.00 -12.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30182501 5 COSMIC
COSN30179121 7 COSMIC
COSN30114628 12 COSMIC
COSN26646726 18 COSMIC
COSN26726635 26 COSMIC
COSN31495355 29 COSMIC
COSN26481884 38 COSMIC
COSN31496891 38 COSMIC
COSN213344 40 COSMIC
COSN19660860 41 COSMIC
COSN26669270 49 COSMIC
COSN26646725 55 COSMIC
COSN30597041 82 COSMIC
COSN15748185 345 COSMIC
COSN15714850 488 COSMIC
COSN9850630 500 COSMIC
COSN5438242 557 COSMIC
COSN16147986 598 COSMIC
COSN15947761 681 COSMIC
COSN32159913 960 COSMIC
COSN26614844 1041 COSMIC
COSN1768817 1136 COSMIC
COSN8972787 1285 COSMIC
COSN21896622 1509 COSMIC
COSN20934661 1575 COSMIC
COSN7445812 1638 COSMIC
COSN7445811 1723 COSMIC
COSN19079834 1724 COSMIC
COSN26383055 1772 COSMIC
COSN20088343 1891 COSMIC
COSN30542509 1913 COSMIC
COSN31660740 1930 COSMIC
COSN31975990 1939 COSMIC
COSN30539597 1990 COSMIC
COSN31571024 2046 COSMIC
COSN31606665 2051 COSMIC
COSN7445810 2111 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757440966 1 dbSNP
rs777352607 3 dbSNP
rs566095700 5 dbSNP
rs761028412 6 dbSNP
rs201068330 8 dbSNP
rs767314495 9 dbSNP
rs759402625 10 dbSNP
rs372502916 15 dbSNP
rs1409574122 17 dbSNP
rs1209584646 18 dbSNP
rs1354946847 19 dbSNP
rs754893393 20 dbSNP
rs375352796 21 dbSNP
rs1434922934 28 dbSNP
rs1176826672 29 dbSNP
rs762426417 30 dbSNP
rs772817013 35 dbSNP
rs1229719806 37 dbSNP
rs769326109 40 dbSNP
rs747891581 41 dbSNP
rs372986716 42 dbSNP
rs1331877168 44 dbSNP
rs772565218 45 dbSNP
rs1386001825 47 dbSNP
rs746334137 49 dbSNP
rs779583021 50 dbSNP
rs539012751 51 dbSNP
rs1182088256 55 dbSNP
rs1278299541 55 dbSNP
rs1285542514 56 dbSNP
rs569884772 57 dbSNP
rs370131978 60 dbSNP
rs1200076122 65 dbSNP
rs1186430852 66 dbSNP
rs1484643592 69 dbSNP
rs1247876778 70 dbSNP
rs1037867115 71 dbSNP
rs765294947 73 dbSNP
rs1358222096 76 dbSNP
rs906064582 77 dbSNP
rs1199929189 80 dbSNP
rs1044614685 81 dbSNP
rs1230390172 86 dbSNP
rs1171636069 89 dbSNP
rs950337389 90 dbSNP
rs917236438 91 dbSNP
rs1370521493 92 dbSNP
rs181938179 94 dbSNP
rs567405613 107 dbSNP
rs1305397442 109 dbSNP
rs1329704584 114 dbSNP
rs768358697 118 dbSNP
rs1359963724 124 dbSNP
rs1304974036 128 dbSNP
rs559977141 129 dbSNP
rs752386182 132 dbSNP
rs541596303 133 dbSNP
rs1270866465 134 dbSNP
rs978861283 143 dbSNP
rs574388093 146 dbSNP
rs1197830198 147 dbSNP
rs1373317122 150 dbSNP
rs910418486 155 dbSNP
rs987380163 157 dbSNP
rs1388991896 163 dbSNP
rs954609628 169 dbSNP
rs1166020145 171 dbSNP
rs1389126844 175 dbSNP
rs971726108 180 dbSNP
rs113444322 186 dbSNP
rs1015996458 194 dbSNP
rs1199462073 196 dbSNP
rs1001937217 205 dbSNP
rs1248180394 213 dbSNP
rs1315131045 217 dbSNP
rs1209058443 218 dbSNP
rs868190052 219 dbSNP
rs753653851 220 dbSNP
rs1266396949 221 dbSNP
rs1448424232 222 dbSNP
rs1186271761 227 dbSNP
rs1206844980 232 dbSNP
rs1246958758 234 dbSNP
rs1444727328 235 dbSNP
rs906032141 236 dbSNP
rs1367267893 245 dbSNP
rs1457815726 249 dbSNP
rs1023129706 254 dbSNP
rs36042844 254 dbSNP
rs1014378958 260 dbSNP
rs1455909310 260 dbSNP
rs1320150323 261 dbSNP
rs896036477 263 dbSNP
rs1310620576 265 dbSNP
rs1053794299 278 dbSNP
rs934656719 281 dbSNP
rs780488511 286 dbSNP
rs1261156475 287 dbSNP
rs1330952976 299 dbSNP
rs867906219 301 dbSNP
rs1461456278 305 dbSNP
rs527349474 319 dbSNP
rs1043151053 322 dbSNP
rs1205059916 323 dbSNP
rs1253434785 328 dbSNP
rs564618468 330 dbSNP
rs543086109 339 dbSNP
rs1283812860 342 dbSNP
rs1224254224 345 dbSNP
rs910639503 347 dbSNP
rs766354827 354 dbSNP
rs371618034 356 dbSNP
rs761750465 357 dbSNP
rs563876982 358 dbSNP
rs544047805 370 dbSNP
rs1301222499 372 dbSNP
rs1460944084 381 dbSNP
rs1432137866 385 dbSNP
rs1391968542 390 dbSNP
rs919156330 391 dbSNP
rs1352198491 404 dbSNP
rs972413108 405 dbSNP
rs1177761984 411 dbSNP
rs188143188 415 dbSNP
rs1253806412 419 dbSNP
rs1479859514 420 dbSNP
rs139901405 425 dbSNP
rs1015916513 427 dbSNP
rs1482338316 430 dbSNP
rs541561350 438 dbSNP
rs1430401332 442 dbSNP
rs1249585963 445 dbSNP
rs368659536 447 dbSNP
rs183715840 468 dbSNP
rs1462579867 473 dbSNP
rs1263741020 483 dbSNP
rs1202955412 485 dbSNP
rs191614888 488 dbSNP
rs539075053 489 dbSNP
rs1322918485 490 dbSNP
rs570029567 491 dbSNP
rs1220673788 495 dbSNP
rs1298759544 496 dbSNP
rs556184652 497 dbSNP
rs1311202375 505 dbSNP
rs1014347946 507 dbSNP
rs1241474677 508 dbSNP
rs1276121079 515 dbSNP
rs1340730364 517 dbSNP
rs1205064797 524 dbSNP
rs1336534284 531 dbSNP
rs1489677145 534 dbSNP
rs536504074 539 dbSNP
rs1266976815 541 dbSNP
rs1031905594 543 dbSNP
rs1170616794 547 dbSNP
rs1408744741 549 dbSNP
rs999543447 551 dbSNP
rs904517399 552 dbSNP
rs1469679149 555 dbSNP
rs1403285260 557 dbSNP
rs567364042 558 dbSNP
rs1291535447 565 dbSNP
rs889173871 573 dbSNP
rs1051865507 575 dbSNP
rs376061972 580 dbSNP
rs1181175254 581 dbSNP
rs1293163235 582 dbSNP
rs919112616 591 dbSNP
rs1446290353 592 dbSNP
rs34878224 599 dbSNP
rs1219873477 604 dbSNP
rs1036272880 607 dbSNP
rs1486348342 608 dbSNP
rs374310043 610 dbSNP
rs1448952109 613 dbSNP
rs909135647 615 dbSNP
rs56217450 616 dbSNP
rs1414487690 623 dbSNP
rs1406987387 624 dbSNP
rs556521223 628 dbSNP
rs1162493660 630 dbSNP
rs56245764 634 dbSNP
rs1349079595 636 dbSNP
rs1454056901 639 dbSNP
rs536257488 641 dbSNP
rs1322146617 647 dbSNP
rs1261371343 655 dbSNP
rs571052378 656 dbSNP
rs969040512 657 dbSNP
rs56246734 664 dbSNP
rs1227090171 668 dbSNP
rs1351469430 670 dbSNP
rs1312543002 671 dbSNP
rs551061725 680 dbSNP
rs55713870 683 dbSNP
rs56315333 686 dbSNP
rs1385446124 690 dbSNP
rs992343150 693 dbSNP
rs531210766 695 dbSNP
rs960223297 699 dbSNP
rs1473771593 709 dbSNP
rs1381177831 710 dbSNP
rs1032293059 714 dbSNP
rs1412900150 715 dbSNP
rs1400840279 721 dbSNP
rs999117043 723 dbSNP
rs1161050373 725 dbSNP
rs1386044863 726 dbSNP
rs1456356501 736 dbSNP
rs968922010 738 dbSNP
rs1360383184 740 dbSNP
rs1343945951 741 dbSNP
rs1021874240 742 dbSNP
rs1007590798 745 dbSNP
rs1286817692 747 dbSNP
rs889098621 751 dbSNP
rs1426096929 753 dbSNP
rs1385654414 756 dbSNP
rs1162650305 766 dbSNP
rs1051864108 767 dbSNP
rs1442511237 771 dbSNP
rs562464754 779 dbSNP
rs1483321415 786 dbSNP
rs147463130 788 dbSNP
rs1193796866 792 dbSNP
rs1426761409 795 dbSNP
rs941865483 801 dbSNP
rs1332886732 803 dbSNP
rs909161709 806 dbSNP
rs561541931 810 dbSNP
rs1044942617 812 dbSNP
rs947740353 814 dbSNP
rs1261053272 815 dbSNP
rs917552983 818 dbSNP
rs1405863726 819 dbSNP
rs187952716 826 dbSNP
rs1343080891 829 dbSNP
rs750976462 830 dbSNP
rs567580578 838 dbSNP
rs1361797771 842 dbSNP
rs1342853183 844 dbSNP
rs1292999615 846 dbSNP
rs1249443843 847 dbSNP
rs575971036 847 dbSNP
rs184930906 848 dbSNP
rs1482612704 858 dbSNP
rs978024842 860 dbSNP
rs968857385 870 dbSNP
rs565425272 877 dbSNP
rs192813865 878 dbSNP
rs143075373 885 dbSNP
rs1167273116 886 dbSNP
rs1370427898 888 dbSNP
rs997525495 895 dbSNP
rs188752201 896 dbSNP
rs1329613027 903 dbSNP
rs148327768 904 dbSNP
rs1298504138 908 dbSNP
rs1302119505 915 dbSNP
rs1006032601 920 dbSNP
rs1421387001 925 dbSNP
rs887586963 926 dbSNP
rs1044973629 930 dbSNP
rs1210254673 932 dbSNP
rs1291733899 947 dbSNP
rs1449574318 949 dbSNP
rs573915638 951 dbSNP
rs1248191445 954 dbSNP
rs896156298 959 dbSNP
rs144335647 960 dbSNP
rs935002566 973 dbSNP
rs372819956 979 dbSNP
rs1458843279 985 dbSNP
rs1490852886 987 dbSNP
rs375430230 988 dbSNP
rs1389016273 990 dbSNP
rs1405065519 997 dbSNP
rs1222016085 998 dbSNP
rs1450237921 1010 dbSNP
rs35356678 1010 dbSNP
rs1275479744 1013 dbSNP
rs979183263 1014 dbSNP
rs1433026702 1017 dbSNP
rs1215691405 1019 dbSNP
rs947551214 1021 dbSNP
rs914711330 1026 dbSNP
rs1339259586 1028 dbSNP
rs1354001939 1031 dbSNP
rs1212780725 1032 dbSNP
rs1268398647 1039 dbSNP
rs1465946821 1041 dbSNP
rs1206331389 1042 dbSNP
rs986384945 1050 dbSNP
rs953650428 1059 dbSNP
rs1190224782 1060 dbSNP
rs1030575597 1061 dbSNP
rs976517893 1064 dbSNP
rs962052587 1067 dbSNP
rs1472687043 1072 dbSNP
rs369680991 1073 dbSNP
rs1006232103 1076 dbSNP
rs887618339 1078 dbSNP
rs183120082 1079 dbSNP
rs1402998011 1082 dbSNP
rs1023383841 1085 dbSNP
rs1402642607 1086 dbSNP
rs1356075975 1105 dbSNP
rs537913173 1107 dbSNP
rs1338582407 1128 dbSNP
rs539514025 1139 dbSNP
rs1400933560 1142 dbSNP
rs896425125 1143 dbSNP
rs1330841574 1144 dbSNP
rs1226182099 1147 dbSNP
rs1394301415 1148 dbSNP
rs149624911 1149 dbSNP
rs571770129 1154 dbSNP
rs1201621873 1169 dbSNP
rs1429992571 1172 dbSNP
rs902150098 1173 dbSNP
rs548991968 1178 dbSNP
rs75108725 1179 dbSNP
rs12984276 1180 dbSNP
rs36072884 1181 dbSNP
rs1205708552 1184 dbSNP
rs910973026 1185 dbSNP
rs986332612 1188 dbSNP
rs932125010 1189 dbSNP
rs1400036507 1195 dbSNP
rs1415712961 1209 dbSNP
rs1414074705 1211 dbSNP
rs773602347 1212 dbSNP
rs1352099359 1213 dbSNP
rs1407701052 1214 dbSNP
rs35894785 1219 dbSNP
rs976337150 1220 dbSNP
rs1282026382 1221 dbSNP
rs1217139988 1226 dbSNP
rs962365173 1227 dbSNP
rs1279742512 1228 dbSNP
rs1014891639 1230 dbSNP
rs192433776 1232 dbSNP
rs527890283 1236 dbSNP
rs187867720 1239 dbSNP
rs1023665249 1244 dbSNP
rs1482287566 1245 dbSNP
rs11879250 1246 dbSNP
rs896299237 1247 dbSNP
rs1196915947 1252 dbSNP
rs1412801826 1261 dbSNP
rs576452393 1262 dbSNP
rs1035363553 1263 dbSNP
rs1372545272 1264 dbSNP
rs562826836 1267 dbSNP
rs1297852613 1269 dbSNP
rs1177981819 1270 dbSNP
rs1470008816 1273 dbSNP
rs138318862 1274 dbSNP
rs1370902876 1279 dbSNP
rs999417543 1280 dbSNP
rs1185978988 1286 dbSNP
rs1462118224 1289 dbSNP
rs1203325515 1294 dbSNP
rs573697883 1305 dbSNP
rs1489304137 1313 dbSNP
rs145910708 1316 dbSNP
rs1043452200 1320 dbSNP
rs1392058499 1321 dbSNP
rs1447757566 1327 dbSNP
rs1169935943 1331 dbSNP
rs1350691041 1332 dbSNP
rs1207466529 1333 dbSNP
rs1010569079 1337 dbSNP
rs1292133093 1341 dbSNP
rs771488697 1343 dbSNP
rs533796984 1349 dbSNP
rs577431572 1358 dbSNP
rs923434737 1359 dbSNP
rs1312900204 1364 dbSNP
rs553556414 1367 dbSNP
rs1041033504 1372 dbSNP
rs11083661 1374 dbSNP
rs1381998026 1377 dbSNP
rs1272281077 1393 dbSNP
rs1354781196 1394 dbSNP
rs1465208234 1396 dbSNP
rs537623992 1397 dbSNP
rs1334580686 1398 dbSNP
rs1210461181 1403 dbSNP
rs908115184 1407 dbSNP
rs1347034067 1416 dbSNP
rs1185999620 1425 dbSNP
rs984788865 1427 dbSNP
rs1160110567 1428 dbSNP
rs182194603 1429 dbSNP
rs916684467 1434 dbSNP
rs1417539791 1435 dbSNP
rs191185761 1436 dbSNP
rs960832677 1437 dbSNP
rs1165819422 1438 dbSNP
rs1430721481 1439 dbSNP
rs186186121 1440 dbSNP
rs999765629 1441 dbSNP
rs771703920 1448 dbSNP
rs1010600291 1449 dbSNP
rs1266085334 1454 dbSNP
rs373457041 1455 dbSNP
rs1049518407 1462 dbSNP
rs997911180 1463 dbSNP
rs902009860 1465 dbSNP
rs1040584403 1476 dbSNP
rs35133459 1477 dbSNP
rs566428222 1477 dbSNP
rs369989927 1479 dbSNP
rs1360344180 1482 dbSNP
rs562446715 1485 dbSNP
rs548116732 1486 dbSNP
rs1049281242 1487 dbSNP
rs1411339815 1489 dbSNP
rs761340002 1491 dbSNP
rs754673583 1493 dbSNP
rs774010470 1495 dbSNP
rs1313962944 1507 dbSNP
rs960862188 1513 dbSNP
rs1279781484 1514 dbSNP
rs1364190340 1516 dbSNP
rs1289474189 1519 dbSNP
rs183282029 1520 dbSNP
rs1469969248 1521 dbSNP
rs571889570 1523 dbSNP
rs191460309 1526 dbSNP
rs1425756921 1527 dbSNP
rs1385003644 1529 dbSNP
rs966928646 1534 dbSNP
rs1431219781 1535 dbSNP
rs1163306063 1537 dbSNP
rs1022238809 1538 dbSNP
rs533637451 1538 dbSNP
rs1436943868 1542 dbSNP
rs1276472356 1543 dbSNP
rs1365395911 1547 dbSNP
rs113971049 1553 dbSNP
rs1279667345 1554 dbSNP
rs1343006952 1560 dbSNP
rs1185467829 1563 dbSNP
rs1271165183 1565 dbSNP
rs1487009143 1567 dbSNP
rs1270671092 1568 dbSNP
rs542569794 1570 dbSNP
rs780247215 1571 dbSNP
rs1409544503 1574 dbSNP
rs1263398011 1575 dbSNP
rs1027953089 1577 dbSNP
rs1165732559 1588 dbSNP
rs998255673 1591 dbSNP
rs1405657402 1594 dbSNP
rs900953119 1595 dbSNP
rs1294733540 1596 dbSNP
rs1392076163 1597 dbSNP
rs1440032291 1599 dbSNP
rs1298274724 1601 dbSNP
rs531804728 1603 dbSNP
rs1365951026 1609 dbSNP
rs1218149773 1611 dbSNP
rs1338507733 1612 dbSNP
rs1338968946 1613 dbSNP
rs1285506222 1619 dbSNP
rs1405709646 1622 dbSNP
rs1390489558 1624 dbSNP
rs1467439149 1627 dbSNP
rs140727640 1629 dbSNP
rs1463820761 1630 dbSNP
rs542710303 1631 dbSNP
rs529261665 1632 dbSNP
rs1476592066 1633 dbSNP
rs886582784 1634 dbSNP
rs1472906523 1635 dbSNP
rs181700028 1636 dbSNP
rs1415334809 1637 dbSNP
rs551623499 1638 dbSNP
rs577544625 1639 dbSNP
rs1055166164 1643 dbSNP
rs1245743252 1645 dbSNP
rs55967441 1646 dbSNP
rs1480826323 1650 dbSNP
rs1333072059 1656 dbSNP
rs544433903 1664 dbSNP
rs1467200421 1668 dbSNP
rs1196673253 1669 dbSNP
rs1203941242 1670 dbSNP
rs978559343 1672 dbSNP
rs781616827 1690 dbSNP
rs1442520847 1693 dbSNP
rs945204697 1695 dbSNP
rs1265028228 1699 dbSNP
rs1159610765 1703 dbSNP
rs915043525 1708 dbSNP
rs575341212 1709 dbSNP
rs1330778842 1711 dbSNP
rs757778443 1720 dbSNP
rs1396689210 1721 dbSNP
rs189368686 1723 dbSNP
rs1353790534 1724 dbSNP
rs1414451690 1724 dbSNP
rs535503222 1724 dbSNP
rs976471251 1724 dbSNP
rs750438534 1731 dbSNP
rs1374503729 1734 dbSNP
rs965396408 1741 dbSNP
rs1015358290 1743 dbSNP
rs751592595 1750 dbSNP
rs1004338055 1765 dbSNP
rs1253654078 1769 dbSNP
rs886613761 1775 dbSNP
rs1407689946 1780 dbSNP
rs566490287 1784 dbSNP
rs777864712 1788 dbSNP
rs1467579810 1790 dbSNP
rs1175584024 1793 dbSNP
rs1027819928 1802 dbSNP
rs1465081778 1804 dbSNP
rs1434304291 1810 dbSNP
rs751909429 1815 dbSNP
rs1183522911 1816 dbSNP
rs1225852597 1823 dbSNP
rs1306822217 1827 dbSNP
rs375013739 1835 dbSNP
rs895432349 1847 dbSNP
rs1055767506 1858 dbSNP
rs1300587335 1859 dbSNP
rs758519549 1860 dbSNP
rs1252712668 1863 dbSNP
rs1479496741 1866 dbSNP
rs1195003871 1867 dbSNP
rs1389039470 1869 dbSNP
rs1042485264 1879 dbSNP
rs945403407 1881 dbSNP
rs552975230 1887 dbSNP
rs186571936 1890 dbSNP
rs1169396191 1892 dbSNP
rs756237070 1893 dbSNP
rs1297941763 1899 dbSNP
rs571950017 1903 dbSNP
rs1324118327 1904 dbSNP
rs1443704029 1910 dbSNP
rs753015061 1914 dbSNP
rs1369535063 1919 dbSNP
rs551785333 1924 dbSNP
rs751406254 1925 dbSNP
rs1226295652 1926 dbSNP
rs1265777032 1926 dbSNP
rs1469673186 1927 dbSNP
rs1211683041 1936 dbSNP
rs760586698 1936 dbSNP
rs1252305679 1941 dbSNP
rs1465345628 1944 dbSNP
rs1421803545 1946 dbSNP
rs533474607 1953 dbSNP
rs1334429569 1960 dbSNP
rs1369362768 1963 dbSNP
rs763013129 1966 dbSNP
rs1163319890 1970 dbSNP
rs1436533236 1974 dbSNP
rs372908247 1974 dbSNP
rs560458471 1974 dbSNP
rs1359302660 1976 dbSNP
rs772583163 1980 dbSNP
rs1346057640 1982 dbSNP
rs145251164 1985 dbSNP
rs761863101 1991 dbSNP
rs1343446892 1992 dbSNP
rs1174200941 1997 dbSNP
rs1217914463 1998 dbSNP
rs180709153 2001 dbSNP
rs1410412216 2002 dbSNP
rs763195186 2005 dbSNP
rs994991887 2009 dbSNP
rs1476347520 2012 dbSNP
rs1163207621 2015 dbSNP
rs189476836 2020 dbSNP
rs1401759413 2024 dbSNP
rs1161950008 2026 dbSNP
rs1188063584 2027 dbSNP
rs1450314189 2028 dbSNP
rs1452439032 2029 dbSNP
rs1033948940 2031 dbSNP
rs1415670499 2032 dbSNP
rs1356965095 2033 dbSNP
rs1004168441 2040 dbSNP
rs529321972 2055 dbSNP
rs765506711 2061 dbSNP
rs1350918454 2063 dbSNP
rs1225347051 2069 dbSNP
rs1181988250 2070 dbSNP
rs1315133587 2072 dbSNP
rs1042820536 2073 dbSNP
rs1009561907 2074 dbSNP
rs1486762011 2075 dbSNP
rs1442150338 2081 dbSNP
rs893922595 2082 dbSNP
rs1202657497 2094 dbSNP
rs112420536 2096 dbSNP
rs1179398471 2098 dbSNP
rs75040189 2098 dbSNP
rs921064827 2099 dbSNP
rs749819900 2100 dbSNP
rs200942447 2101 dbSNP
rs943994064 2101 dbSNP
rs1183320424 2109 dbSNP
rs12268 2111 dbSNP
rs1311920784 2112 dbSNP
rs1354842425 2113 dbSNP
rs533145483 2115 dbSNP
rs1312373288 2120 dbSNP
rs908449607 2122 dbSNP
rs1238491453 2130 dbSNP
rs1372509187 2135 dbSNP
rs1362026655 2137 dbSNP
rs982443250 2142 dbSNP
rs1350180725 2144 dbSNP
rs1208935977 2145 dbSNP
rs1316441218 2146 dbSNP
rs775267641 2148 dbSNP
rs952364438 2150 dbSNP
rs1207051431 2161 dbSNP
rs1231579916 2162 dbSNP
rs564450460 2164 dbSNP
rs1194840837 2166 dbSNP
rs1338209392 2169 dbSNP
rs1452048538 2170 dbSNP
rs1172556895 2172 dbSNP
rs1319666497 2175 dbSNP
rs991170425 2191 dbSNP
rs959574235 2195 dbSNP
rs1326580402 2199 dbSNP
rs1353745536 2199 dbSNP
rs544128332 2200 dbSNP
rs1441491808 2204 dbSNP
rs35428189 2205 dbSNP
rs1373209231 2210 dbSNP
rs1034224038 2211 dbSNP
rs1003710971 2218 dbSNP
rs1064504 2222 dbSNP
rs1340298441 2225 dbSNP
rs562273957 2230 dbSNP
rs1295943502 2233 dbSNP
rs1216593913 2237 dbSNP
rs971420397 2243 dbSNP
rs770046519 2244 dbSNP
rs575402010 2255 dbSNP
rs1255449646 2257 dbSNP
rs1021192289 2259 dbSNP
rs1192448848 2261 dbSNP
rs1385560827 2264 dbSNP
rs1255020161 2265 dbSNP
rs1162601400 2267 dbSNP
rs1165819893 2268 dbSNP
rs1418464727 2269 dbSNP
rs1471740808 2275 dbSNP
rs1366830250 2282 dbSNP
rs1166923322 2283 dbSNP
rs1009592957 2295 dbSNP
rs544092452 2296 dbSNP
rs1327137763 2304 dbSNP
rs1262813326 2306 dbSNP
rs1268651827 2307 dbSNP
rs1053883837 2308 dbSNP
rs1214722691 2308 dbSNP
rs996896764 2311 dbSNP
rs777081837 2319 dbSNP
rs899914530 2325 dbSNP
rs111583711 2328 dbSNP
rs564120111 2336 dbSNP
rs1261761199 2340 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000327495.5 | 3UTR | ucaagaucauaccacug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000327495.5 | 3UTR | ucaagaucauaccacug
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
29 hsa-miR-4540 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT154897 GNAS GNAS complex locus 2 2
MIRT444915 PSG11 pregnancy specific beta-1-glycoprotein 11 2 2
MIRT446718 PSG3 pregnancy specific beta-1-glycoprotein 3 2 2
MIRT464587 UBN2 ubinuclein 2 2 2
MIRT468816 RSRC2 arginine and serine rich coiled-coil 2 2 6
MIRT469397 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT491901 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT498959 ORC4 origin recognition complex subunit 4 2 8
MIRT499438 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT506234 PEX13 peroxisomal biogenesis factor 13 2 4
MIRT527911 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT532624 PHF5A PHD finger protein 5A 2 2
MIRT538103 DDX6 DEAD-box helicase 6 2 2
MIRT549032 CASZ1 castor zinc finger 1 2 2
MIRT559870 ATXN3 ataxin 3 2 2
MIRT575888 Ablim1 actin-binding LIM protein 1 2 4
MIRT608663 ABLIM1 actin binding LIM protein 1 2 5
MIRT616515 C9orf170 chromosome 9 open reading frame 170 2 2
MIRT624063 EID1 EP300 interacting inhibitor of differentiation 1 2 2
MIRT625533 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 2
MIRT637169 TMEM50A transmembrane protein 50A 2 2
MIRT639274 KLHL23 kelch like family member 23 2 2
MIRT642924 CCDC90B coiled-coil domain containing 90B 2 2
MIRT649085 FBXO25 F-box protein 25 2 2
MIRT655089 PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2 2
MIRT700888 PER2 period circadian clock 2 2 2
MIRT705966 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT709418 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT723921 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4540 Topotecan 60699 NSC609699 approved resistant cell line (W1)
hsa-miR-4540 Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-4540 Platinum 23939 resistant tissue (non-small cell lung cancer)

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