miRTarBase - #MIRT446951


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-3p
Sequence 52| UUUGUGACCUGGUCCACUAACC |73
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs992122694 10 dbSNP
rs1165305945 14 dbSNP
rs1432780238 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CD248   
Synonyms CD164L1, TEM1
Description CD248 molecule
Transcript NM_020404   
Expression
Putative miRNA Targets on CD248
3'UTR of CD248
(miRNA target sites are highlighted)		 
>CD248|NM_020404|3'UTR
   1 TGGGGTGCAGACCCCCCTCATGGAGTATGGGGCGCTGGACACATGGCCGGGGCTGCACCAGGGACCCATGGGGGCTGCCC
  81 AGCTGGACAGATGGCTTCCTGCTCCCCAGGCCCAGCCAGGGTCCTCTCTCAACCACTAGACTTGGCTCTCAGGAACTCTG
 161 CTTCCTGGCCCAGCGCTCGTGACCAAGGATACACCAAAGCCCTTAAGACCTCAGGGGGCGGGTGCTGGGGTCTTCTCCAA
 241 TAAATGGGGTGTCAACCTTACCCAAGGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccaAUCACCUG-GUCCAGUGUuu 5'
             ||  ||:| | || ||||  
Target 5' gagTATGGGGCGCTGGACACAtg 3'
 23 - 45 107.00 -11.70
2 
miRNA  3' ccaAUCACCUGG-UCCAGUGUuu 5'
             | || |||| ||| :|||  
Target 5' cgcTCGT-GACCAAGGATACAcc 3'
 174 - 195 98.00 -10.70
3 
miRNA  3' ccAAUCACCUGGUCCAGUguuu 5'
            | | |||:  : ||||    
Target 5' aaTAAATGGG--GTGTCAacct 3'
 239 - 258 88.00 -6.06
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30136071 33 COSMIC
COSN31618045 34 COSMIC
COSN26602009 42 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1261725077 1 dbSNP
rs556175547 5 dbSNP
rs1207422889 6 dbSNP
rs1201180178 7 dbSNP
rs1483395973 7 dbSNP
rs1049792532 8 dbSNP
rs1233434322 9 dbSNP
rs182547559 10 dbSNP
rs79764462 12 dbSNP
rs949201887 13 dbSNP
rs1334811107 14 dbSNP
rs753025612 15 dbSNP
rs542258863 16 dbSNP
rs1411176059 17 dbSNP
rs765372876 19 dbSNP
rs1312870702 20 dbSNP
rs1413253317 24 dbSNP
rs1427798137 28 dbSNP
rs1298625212 29 dbSNP
rs573289047 33 dbSNP
rs939345534 34 dbSNP
rs754165698 36 dbSNP
rs988027501 38 dbSNP
rs1339288320 39 dbSNP
rs113994216 43 dbSNP
rs925923061 46 dbSNP
rs979199027 47 dbSNP
rs1210154370 48 dbSNP
rs761294149 49 dbSNP
rs374558773 58 dbSNP
rs990472938 66 dbSNP
rs953285092 73 dbSNP
rs1488023915 76 dbSNP
rs998289490 79 dbSNP
rs1265681123 89 dbSNP
rs1459622136 90 dbSNP
rs1421804111 93 dbSNP
rs757467900 94 dbSNP
rs79993621 100 dbSNP
rs1368969573 114 dbSNP
rs1015735531 134 dbSNP
rs1004403833 153 dbSNP
rs1198948168 160 dbSNP
rs112329883 170 dbSNP
rs537605706 174 dbSNP
rs188495716 175 dbSNP
rs887964631 176 dbSNP
rs555697515 178 dbSNP
rs904858998 179 dbSNP
rs1247579808 181 dbSNP
rs1284537468 189 dbSNP
rs1353053072 192 dbSNP
rs1217493364 204 dbSNP
rs1288418159 219 dbSNP
rs1482431323 219 dbSNP
rs1012821685 220 dbSNP
rs115152574 225 dbSNP
rs1057099331 227 dbSNP
rs566856982 230 dbSNP
rs1419739930 232 dbSNP
rs1382197905 237 dbSNP
rs1332118162 245 dbSNP
rs112350402 246 dbSNP
rs1052289412 249 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccaaucaccugguccAGUGUUu 5'
                         |||||| 
Target 5' ---------ucaagcUCACAAa 3'
 		1 - 13
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000311330.3 | 3UTR | UCAAGCUCACAAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER- ER- breast cancer 0.401 1.2e-4 0.413 7.8e-5 79 Click to see details
GSE19536 Breast cancer 0.358 1.3e-4 0.363 1.0e-4 100 Click to see details
GSE21687 Ependynoma primary tumors 0.397 5.8e-4 0.444 1.2e-4 64 Click to see details
GSE32688 Pancreatic cancer 0.466 3.6e-3 0.400 1.2e-2 32 Click to see details
GSE19350 CNS germ cell tumors 0.645 1.2e-2 0.629 1.4e-2 12 Click to see details
GSE21849 B cell lymphoma -0.41 1.4e-2 -0.283 6.8e-2 29 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.393 2.6e-2 -0.438 1.4e-2 25 Click to see details
GSE17306 Multiple myeloma -0.16 1.4e-1 0.169 1.2e-1 49 Click to see details
GSE28544 Breast cancer -0.214 1.6e-1 -0.306 7.3e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.208 1.9e-1 -0.150 2.6e-1 20 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.158 2.3e-1 0.183 1.9e-1 25 Click to see details
GSE17498 Multiple myeloma 0.116 2.4e-1 0.155 1.7e-1 40 Click to see details
GSE19783 ER+ ER+ breast cancer 0.166 2.4e-1 0.290 1.1e-1 20 Click to see details
GSE28260 Renal cortex and medulla -0.181 2.8e-1 -0.357 1.2e-1 13 Click to see details
GSE27834 Pluripotent stem cells 0.105 3.5e-1 0.126 3.2e-1 16 Click to see details
GSE27834 Pluripotent stem cells 0.105 3.5e-1 0.126 3.2e-1 16 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.622 0 0.601 0 42 Click to see details
KIRC 0.508 0 0.483 0 52 Click to see details
LUSC 0.567 0 0.492 0 38 Click to see details
BRCA 0.37 0 0.338 0 84 Click to see details
KIRP 0.499 0 0.427 0.01 29 Click to see details
THCA 0.366 0 0.344 0.01 50 Click to see details
KICH 0.528 0 0.534 0 23 Click to see details
PAAD 0.947 0.03 0.800 0.1 4 Click to see details
ESCA 0.564 0.04 0.582 0.03 11 Click to see details
LIHC 0.243 0.05 0.395 0 49 Click to see details
CESC 0.969 0.08 1.000 0.5 3 Click to see details
PCPG -0.968 0.08 -1.000 0.5 3 Click to see details
CHOL 0.415 0.13 0.533 0.07 9 Click to see details
UCEC 0.267 0.13 0.414 0.04 19 Click to see details
LUAD 0.334 0.14 0.329 0.15 12 Click to see details
COAD -0.427 0.15 -0.381 0.18 8 Click to see details
BLCA 0.2 0.21 0.150 0.28 18 Click to see details
PRAD 0.099 0.25 0.073 0.31 50 Click to see details
STAD 0.083 0.33 0.060 0.37 32 Click to see details
STAD 0.083 0.33 0.060 0.37 32 Click to see details
STAD 0.083 0.33 0.060 0.37 32 Click to see details
48 hsa-miR-758-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118609 NCOA3 nuclear receptor coactivator 3 2 2
MIRT122451 SMIM13 small integral membrane protein 13 2 2
MIRT438602 TLR7 toll like receptor 7 3 1
MIRT438603 TLR3 toll like receptor 3 3 1
MIRT446951 CD248 CD248 molecule 2 2
MIRT447942 AKR7A2 aldo-keto reductase family 7 member A2 2 2
MIRT450648 TMEM70 transmembrane protein 70 2 2
MIRT463976 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT465151 TSC22D2 TSC22 domain family member 2 2 2
MIRT468670 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT469019 RNF41 ring finger protein 41 2 2
MIRT475623 HMGA1 high mobility group AT-hook 1 2 4
MIRT485794 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT492982 NAV1 neuron navigator 1 2 2
MIRT493720 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT498889 RBM12B RNA binding motif protein 12B 2 4
MIRT499194 TJAP1 tight junction associated protein 1 2 2
MIRT499331 RAB25 RAB25, member RAS oncogene family 2 2
MIRT510550 WTAP WT1 associated protein 2 4
MIRT524405 COL4A1 collagen type IV alpha 1 chain 2 4
MIRT530160 C11orf44 chromosome 11 open reading frame 44 2 2
MIRT534595 RORA RAR related orphan receptor A 2 2
MIRT538452 CNKSR2 connector enhancer of kinase suppressor of Ras 2 2 2
MIRT543494 MDM2 MDM2 proto-oncogene 2 4
MIRT547860 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT553785 TACC1 transforming acidic coiled-coil containing protein 1 2 2
MIRT553903 SUN2 Sad1 and UNC84 domain containing 2 2 4
MIRT559303 ATXN1 ataxin 1 2 2
MIRT563350 ZNF181 zinc finger protein 181 2 2
MIRT565404 TFDP1 transcription factor Dp-1 2 2
MIRT566891 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT613227 CCDC39 coiled-coil domain containing 39 2 2
MIRT613470 TG thyroglobulin 2 4
MIRT619930 WSCD2 WSC domain containing 2 2 2
MIRT627180 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT632962 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT634304 SNTN sentan, cilia apical structure protein 2 2
MIRT635292 IRX2 iroquois homeobox 2 2 2
MIRT639740 SLC1A1 solute carrier family 1 member 1 2 2
MIRT641892 SMNDC1 survival motor neuron domain containing 1 2 2
MIRT645871 PRRG3 proline rich and Gla domain 3 2 2
MIRT648691 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT650048 KRBA1 KRAB-A domain containing 1 2 2
MIRT667626 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT669725 A1CF APOBEC1 complementation factor 2 2
MIRT710429 BTNL3 butyrophilin like 3 2 2
MIRT710805 SLC4A1AP solute carrier family 4 member 1 adaptor protein 2 2
MIRT723980 SOX17 SRY-box 17 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-3p (1-(((2-amino-6-chloro-4-pyrimidinyl)amino)methyl)-3-isopropylcyclobutyl)methanol 385230 NSC676343 sensitive
hsa-miR-758-3p (2e)-2-hydroxyimino-4-(3-methyl-4-oxido-1-oxoquinoxalin-1-ium-2-yl)-4-oxo-n-(2,4,5-trichlorophenyl)butanamide 6399319 NSC635544 resistant
hsa-miR-758-3p (2E,5Z)-2-[(5-acetyl-4-methyl-1,3-thiazol-2-yl)hydrazinylidene]-5-[(2-methoxyphenyl)methylidene]-1,3-thiazolidin-4-one 135472679 NSC658292 sensitive
hsa-miR-758-3p (2S,6S,7S,12R)-16-bromo-9-tert-butyl-4-phenyl-4,20-diazapentacyclo[11.7.0.02,6.07,12.014,19]icosa-1(13),14(19),15,17-tetraene-3,5-dione 372657 NSC648154 sensitive
hsa-miR-758-3p (3-(trifluoromethyl)anilino)(2-(trifluoromethyl)phenyl)acetonitrile 375079 NSC654017 resistant
hsa-miR-758-3p (3e)-3-[(2-chloro-1-phenylindol-3-yl)methylidene]-5-methoxy-1h-indol-2-one 5471470 NSC711610 sensitive
hsa-miR-758-3p (4E)-2-(2-hydroxybenzoyl)-5-methyl-4-[(4-nitrophenyl)methylidene]pyrazol-3-one 5467414 NSC652175 sensitive
hsa-miR-758-3p (E)-1-[4-(quinazolin-4-ylamino)phenyl]-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 155816064 NSC760015 sensitive
hsa-miR-758-3p (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamide 51003603 NSC761184 resistant
hsa-miR-758-3p (NE)-N-[(6E)-2-[(hydroxyamino)-(4-phenylmethoxyphenyl)methyl]-6-[(4-phenylmethoxyphenyl)methylidene]cyclohexylidene]hydroxylamine 5928828 NSC632824 resistant
hsa-miR-758-3p [(11bR)-9,10-dimethoxy-4-phenylimino-2,6,7,11b-tetrahydro-1H-[1,3]thiazino[4,3-a]isoquinolin-1-yl]methyl benzoate 371073 NSC645016 sensitive
hsa-miR-758-3p [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,12-diacetyloxy-15-[(2r,3s)-3-benzamido-2-hydroxy-3-(2-methylphenyl)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]hepta 383478 NSC671870 sensitive
hsa-miR-758-3p [(4e)-4-[2-(3,3,6a,10b-tetramethyl-8-methylidene-1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxin-7-yl)ethylidene]-5-oxooxolan-3-yl] acetate 25121273 NSC750035 resistant
hsa-miR-758-3p [1-[[[2-amino-6-chloro-5-[(4-chlorophenyl)diazenyl]pyrimidin-4-yl]amino]methyl]-3-phenylmethoxycyclobutyl]methanol 385284 NSC676395 resistant
hsa-miR-758-3p [5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl [5-[5-fluoro-4-(octadecylamino)-2-oxopyrimidin-1-yl]-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate 390213 NSC687370 sensitive
hsa-miR-758-3p [acetyl-[5-(trityloxymethyl)spiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclopentane]-6-yl]amino] acetate 374290 NSC651809 sensitive
hsa-miR-758-3p {2-[(benzylamino)methyl]-1h-indole-1,3-diyl}bis(phenylmethanone) 374841 NSC653267 sensitive
hsa-miR-758-3p 1-(2-methoxyphenyl)-3-[(z)-1-(2-pyridyl)ethylideneamino]thiourea 5367237 NSC668297 resistant
hsa-miR-758-3p 1-(9-methoxy-11,12-dihydro-6h-indolo[1,2-b][2]benzazepin-13-yl)ethanone 365697 NSC633551 sensitive
hsa-miR-758-3p 1-[(4-bromophenyl)amino]cyclopentanecarbonitrile 238637 NSC43101 resistant
hsa-miR-758-3p 1-[5-[[[4-chlorobutyl(methyl)amino]-[(5-nitrofuran-2-yl)methoxy]phosphoryl]oxymethyl]-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione 404846 NSC721390 sensitive
hsa-miR-758-3p 1-benzyl-2-methyl-1-(2-phenylethyl)-4,5-dihydroimidazol-1-ium 413544 NSC49460 sensitive
hsa-miR-758-3p 16-methoxy-4-(4-methoxyphenyl)-9-propan-2-yl-4,20-diazapentacyclo[11.7.0.02,6.07,12.014,19]icosa-1(13),14(19),15,17-tetraene-3,5-dione 390916 NSC689137 sensitive
hsa-miR-758-3p 17-acetyl-9,14-dihydroxy-16-methyl-15-(4-methylphenyl)-15-azatetracyclo[8.7.0.01,14.03,8]heptadeca-3,5,7,9,12,16-hexaene-2,11-dione 405612 NSC722982 resistant
hsa-miR-758-3p 2'-(4-chlorobenzoyl)-1'-(4-chlorophenyl)-1'-hydroxyspiro[1,3-dihydro-1-benzazepine-4,4'-cyclohexane]-2,5-dione 388188 NSC682756 sensitive
hsa-miR-758-3p 2-(4-chlorophenyl)-1-methylene-3-phenyl-pyrazino[1,2-a]benzimidazole 390230 NSC687522 resistant
hsa-miR-758-3p 2-(hydroxymethyl)-5-[6-(2-propan-2-ylidenehydrazinyl)purin-9-yl]oxolane-3,4-diol 60147745 NSC752330 resistant
hsa-miR-758-3p 2-(trifluoromethyl)benzimidazo[2,1-b][1,3,5]benzothiadiazepin-12(13h)-imine 383194 NSC671313 sensitive
hsa-miR-758-3p 2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethyl n-[6-[2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethoxycarbonylamino]hexyl] 367630 NSC637505 sensitive
hsa-miR-758-3p 2-[2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]acetic acid 5934333 NSC643813 sensitive
hsa-miR-758-3p 2-[9-[(7-oxocyclohepta-1,3,5-trien-1-yl)amino]nonylamino]cyclohepta-2,4,6-trien-1-one 358331 NSC618296 sensitive
hsa-miR-758-3p 2-acetyl-1,2-dihydroellipticine 376328 NSC657149 resistant
hsa-miR-758-3p 2-azaadenine 5480214 NSC57048 resistant
hsa-miR-758-3p 2-methyl-1-[10-[(2-methylquinolin-4-yl)amino]decyl]quinolin-1-ium-4-amine;chloride;hydrochloride 387885 NSC682096 sensitive
hsa-miR-758-3p 2-methyl-4,4-diphenyl-1,4-benzoxaphosphinin-4-ium;bromide 24199840 NSC346098 sensitive
hsa-miR-758-3p 2-methylellpticinium 21123185 NSC351710 sensitive
hsa-miR-758-3p 2-methylolivacinium acetate 5458752 NSC336003 sensitive
hsa-miR-758-3p 2-n-methyl-6-thiaellipticinum iodide 367888 NSC638066 sensitive
hsa-miR-758-3p 2,2'-spirobi[indane]-5,5'-dicarbaldehyde 382743 NSC670421 sensitive
hsa-miR-758-3p 2,3-dibenzoyloxy-4-hydroxy-4-oxobutanoate;(2,5-dimethylphenyl)-(4-methylphenyl)-phenylsulfanium 5351228 NSC116693 sensitive
hsa-miR-758-3p 2,5-dibenzyl-2-undecyloctahydro-1h-pyrrolo[3,4-c]pyridin-2-ium bromide 378731 NSC661832 sensitive
hsa-miR-758-3p 2,5,11-trimethyl-9-phenoxy-6h-pyrido[4,3-b]carbazol-2-ium;acetate 10431819 NSC650269 sensitive
hsa-miR-758-3p 2,5,12-trimethyl-[1,4]benzodioxino[3,2-g]isoquinolin-2-ium acetate 388316 NSC683048 sensitive
hsa-miR-758-3p 3-(4-methoxyphenyl)-4-methyl-8-pyrrolidin-1-yl-8H-thieno[2,3-b]pyrrolizin-4-ium;iodide 388538 NSC683518 sensitive
hsa-miR-758-3p 3-(hydroxymethyl)-5-(6-methylsulfanylpurin-9-yl)-1,4-dioxane-2,6-diol 269951 NSC111702 resistant
hsa-miR-758-3p 3-bromo-4-(3,3-dimethyl-but-1-ynyl)-2(5h)-furanone 11413833 NSC726328 resistant
hsa-miR-758-3p 3,3-bis(3-(trifluoromethyl)phenyl)naphtho[1,2-c]furan-1(3h)-one 362080 NSC625603 sensitive
hsa-miR-758-3p 4-(4-carbazol-9-ylbutanoylamino)-n-[5-[3-(dimethylamino)propylcarbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide 406397 NSC724462 sensitive
hsa-miR-758-3p 4-(bromomethyl)-2,2,5,5-tetramethyl-1-imidazolidinol 3-oxide 378673 NSC661470 resistant
hsa-miR-758-3p 4-[(13R)-13-hydroxy-13-[(2S,5S)-5-[(2S,5S)-5-[1-hydroxy-13-[(2S)-2-methyl-5-oxo-2H-furan-4-yl]tridecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]-2-methyl-2H-furan-5-one 374064 NSC651320 sensitive
hsa-miR-758-3p 4-[[(Z)-N-benzamido-C-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]carbonimidoyl]diazenyl]benzoic acid 135493923 NSC681974 sensitive
hsa-miR-758-3p 4-[4-(diethylamino)phenyl]-2-(4-hydroxypiperidin-1-yl)-6-(3,4,5-trimethoxyphenyl)pyridine-3-carbonitrile 60148088 NSC753601 resistant
hsa-miR-758-3p 4-[4-[2,3-bis(hydroxymethyl)pyrrol-1-yl]butanoylamino]-n-[5-[[5-[3-(dimethylamino)propylcarbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide 384021 NSC673131 sensitive
hsa-miR-758-3p 4-methoxy-1,5-benzothiazepine-1,1-dioxide 358940 NSC619102 resistant
hsa-miR-758-3p 4-methyl-1,1-diphenyl-1,2,3,4-tetrahydrobenzo(h)phosphinolinium hexafluorophosphate 498151 NSC245398 sensitive
hsa-miR-758-3p 4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1H-2-benzofuran-1-yl)-N-[3-(trifluoromethyl)phenyl]butanamide 369471 NSC641241 sensitive
hsa-miR-758-3p 4-pyridin-3-yl-2-(2,3,5-trichlorophenyl)-1,3-thiazole 24814783 NSC742842 resistant
hsa-miR-758-3p 4,10-bis(3-ethynylphenyl)-4,10-diazatetracyclo[5.5.2.02,6.08,12]tetradec-13-ene-3,5,9,11-tetrone 365547 NSC633253 sensitive
hsa-miR-758-3p 5-benzyl-5h-benzo[b]phosphindole 5-oxide 380786 NSC666496 sensitive
hsa-miR-758-3p 5-hydroxy-3,7-dimethoxy-3',4'-methylenedioxyflavone 5466137 NSC678102 sensitive
hsa-miR-758-3p 5-methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 NSC748147 sensitive
hsa-miR-758-3p 5,11-dimethyl-2-[(pentanoyloxy)methyl]-6h-pyrido[4,3-b]carbazol-2-ium iodide 367409 NSC637130 sensitive
hsa-miR-758-3p 6-aminotoyocamycin 300567 NSC175630 resistant
hsa-miR-758-3p 6-bromosangivamycin 270853 NSC113943 resistant
hsa-miR-758-3p 6,7-dimethyl-4-[(2z)-2-(5-oxooxolan-2-ylidene)ethoxy]chromen-2-one 24205380 NSC735332 resistant
hsa-miR-758-3p 7'-but-3-en-2-yl-7'-(3-phenylmethoxypropyl)spiro[1,3-dioxolane-2,2'-3,4,7a,8,9,10-hexahydro-1h-cyclopenta[i]indolizine]-6'-thione 361486 NSC624523 sensitive
hsa-miR-758-3p 7-[(3-fluorophenyl)methoxy]-9-[(3-fluorophenyl)methyl]-2-[(4-fluorophenyl)methyl]-1-methylpyrido[3,4-b]indol-2-ium 54766740 NSC760181 sensitive
hsa-miR-758-3p 7-hydroxy-2-nonyl-4h-chromen-4-one 5375154 NSC631965 sensitive
hsa-miR-758-3p 8-(6-fluorohexyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380336 NSC665863 resistant
hsa-miR-758-3p 8-[3-(1,3-dioxolan-2-yl)-2-(4-fluorophenyl)propyl]-3-ethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380308 NSC665789 resistant
hsa-miR-758-3p 8-aminoadenosine 259812 NSC90394 resistant
hsa-miR-758-3p 8-chloro-7-methyl-5,5-dioxo-n-phenyl-[1,2,4]triazolo[4,3-b][1,4,2]benzodithiazin-3-amine 400657 NSC713019 sensitive
hsa-miR-758-3p 8-chloro-7-methyl-n-(4-methylphenyl)-5,5-dioxo-[1,2,4]triazolo[4,3-b][1,4,2]benzodithiazin-3-amine 400656 NSC713018 sensitive
hsa-miR-758-3p 8-trichloromethyldihydroberberine 320713 NSC269192 sensitive
hsa-miR-758-3p 9-((2-chloroethyl)thio)acridine 395387 NSC699923 resistant
hsa-miR-758-3p 9-(benzylsulfinyl)-2,7-dimethoxyacridine 395397 NSC699933 resistant
hsa-miR-758-3p 9-bromo-2,3-dimethoxy-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 395805 NSC700693 resistant
hsa-miR-758-3p 9-hydroxy-2-(.beta.-diethylaminoethyl)ellipticinium acetate 72034 NSC311152 sensitive
hsa-miR-758-3p Berberine iodide 72350 NSC150446 sensitive
hsa-miR-758-3p Di-n-octyl-secalonsaure a 430141 NSC268925 sensitive
hsa-miR-758-3p Diaporthein b 54612739 NSC751295 resistant
hsa-miR-758-3p Diethyl (Z)-2-(2,4-dioxo-3-prop-2-ynylpyrimidin-1-yl)but-2-enedioate 5469884 NSC693983 resistant
hsa-miR-758-3p Diethyl 4-hydroxy-2-(4-methoxyphenyl)-6-oxo-4-phenyl-1,3-cyclohexanedicarboxylate 386764 NSC679443 sensitive
hsa-miR-758-3p Ellipticine 3213 NSC71795 sensitive
hsa-miR-758-3p Elliptinium acetate 42722 NSC264137 sensitive
hsa-miR-758-3p Ethyl (E)-3-(6-methoxy-1-thiophen-3-yl-3,4-dihydronaphthalen-2-yl)prop-2-enoate 24205739 NSC736553 sensitive
hsa-miR-758-3p Ethyl 16-(3,4-dimethoxyphenyl)-12,14-diphenyl-10-oxa-3,5,6,8,12,13-hexazatetracyclo[7.7.0.02,6.011,15]hexadeca-1(9),2,4,7,11(15),13-hexaene-4-carboxylate 391836 NSC691424 sensitive
hsa-miR-758-3p Fixierer p 70397 NSC63839 resistant
hsa-miR-758-3p Gtpl10345 378629 NSC661421 resistant
hsa-miR-758-3p Gw701427a 10276395 NSC756323 sensitive
hsa-miR-758-3p Haloprogin 3561 NSC100071 resistant
hsa-miR-758-3p Heteromine a 391982 NSC691767 sensitive
hsa-miR-758-3p Hexyl (e)-3-[(2s,4z)-2-(hydroxymethyl)-4-(4-methyl-3-propan-2-ylpentylidene)-5-oxooxolan-2-yl]prop-2-enoate 5471817 NSC714070 sensitive
hsa-miR-758-3p Hsdb 8106 16129719 NSC676825 resistant
hsa-miR-758-3p Inosine, 6-thio-, 2',3',5'-tripentanoate 4208664 NSC77495 resistant
hsa-miR-758-3p Isobaccharin 5358646 NSC269760 sensitive
hsa-miR-758-3p Isobrucein a 322357 NSC279503 sensitive
hsa-miR-758-3p J3.522.543i 6163542 NSC113053 resistant
hsa-miR-758-3p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-758-3p Kuc100204 378309 NSC660313 sensitive
hsa-miR-758-3p Laurusin 135476719 NSC106486 resistant
hsa-miR-758-3p Maxima isoflavone d 343081 NSC382028 sensitive
hsa-miR-758-3p Mefloquine hydrochloride 456309 NSC157387 resistant
hsa-miR-758-3p Methyl (Z)-4,4-dicyano-4-[(3-methoxyphenyl)methylideneamino]but-2-enoate 5470182 NSC698278 resistant
hsa-miR-758-3p Methyl 4-[3-(2-thienyl)quinoxalin-2-yl]oxybenzoate 388002 NSC682365 sensitive
hsa-miR-758-3p Musennin 267361 NSC106554 sensitive
hsa-miR-758-3p N'-[(Z)-[(4Z)-2-(1,3-benzodioxol-5-yl)-4-[[4-oxo-4-[2-(trifluoromethyl)anilino]butanoyl]hydrazinylidene]chromen-3-ylidene]amino]-N-[2-(trifluoromethyl)phenyl]butanediamide 6399328 NSC641210 sensitive
hsa-miR-758-3p N'-chloro-4-[2-[2-[4-[(Z)-N'-chlorocarbamimidoyl]phenoxy]ethyl-(4-methylphenyl)sulfonylamino]ethoxy]benzenecarboximidamide 45028721 NSC743909 sensitive
hsa-miR-758-3p N-(6-methyl-1,3-benzothiazol-2-yl)-4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1h-2-benzofuran-1-yl)butanamide 369455 NSC641225 sensitive
hsa-miR-758-3p N-[(z)-[phenyl(pyridin-2-yl)methylidene]amino]quinoxalin-2-amine 5869744 NSC693626 resistant
hsa-miR-758-3p N-[2-(dimethylamino)ethyl]-4-(furo[3,2-c]quinolin-4-ylamino)benzamide 24204686 NSC732490 resistant
hsa-miR-758-3p N-[2-chloro-5-(trifluoromethyl)phenyl]-4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1h-2-benzofuran-1-yl)butanamide 369469 NSC641239 sensitive
hsa-miR-758-3p N-benzyl-1-[10-[4-(benzylamino)-2-methylquinolin-1-ium-1-yl]decyl]-2-methylquinolin-1-ium-4-amine;perchlorate 387881 NSC682094 sensitive
hsa-miR-758-3p N,n-dimethyl-4-[(e)-2-(1-methyl-2,5-diphenylpyrazol-1-ium-3-yl)ethenyl]aniline;trifluoromethanesulfonate 5469868 NSC693576 sensitive
hsa-miR-758-3p None 12201866 NSC179207 resistant
hsa-miR-758-3p NSC644919 NSC644919 sensitive
hsa-miR-758-3p NSC699071 NSC699071 sensitive
hsa-miR-758-3p NSC751830 NSC751830 resistant
hsa-miR-758-3p Oxidanium;1,3-diphenylpropane-1,3-dione;neodymium(3+);hydroxide 24202397 NSC647042 sensitive
hsa-miR-758-3p Phenoxathiin-2-ylmethyl carbamimidothioate;hydrochloride 392088 NSC691900 resistant
hsa-miR-758-3p Phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) 10714966 NSC289922 sensitive
hsa-miR-758-3p Propan-2-ylsulfanyl-(2,3,5,6-tetrachloropyridin-4-yl)sulfanylmethanethione 399833 NSC710969 resistant
hsa-miR-758-3p Protein: pahiv4 NSC678525 sensitive
hsa-miR-758-3p Pyrazolanthrone 8515 NSC75890 resistant
hsa-miR-758-3p Pyrimido[5,4-g]pteridine-2,4,6,8(1h,3h,7h,9h)-tetrone, 1,9-bis(methoxymethyl)-3,7-dimethyl-, 5-oxide 385097 NSC676032 sensitive
hsa-miR-758-3p Sarcoviolin 24202820 NSC726045 sensitive
hsa-miR-758-3p Stl298328 387753 NSC681782 resistant
hsa-miR-758-3p Stl323035 383655 NSC672073 sensitive
hsa-miR-758-3p Stl361983 256661 NSC83715 resistant
hsa-miR-758-3p Tetramethyl (1r,5r,6s,9s)-7-[4-[(e)-2,3-bis(4-chlorophenyl)prop-2-enoyl]oxyphenyl]-3,5-dihydroxybicyclo[3.3.1]non-2-ene-2,4,6,9-tetracarboxylate 54681588 NSC717067 resistant
hsa-miR-758-3p Tris(1,10-phenanthroline)lanthanum(iii)-trithiocyanate 24202211 NSC632737 resistant
hsa-miR-758-3p Xestin a 5352066 NSC647638 resistant
hsa-miR-758-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-758-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-758-3p Etoposide 36462 NSC141540 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-758-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Cancer cell line (ECA-109)
hsa-miR-758-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-758-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-758-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-3p Paclitaxel 36314 NSC125973 approved resistant cell line (HeyA8)
hsa-miR-758-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-miR-758-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM36)
hsa-miR-758-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-758-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-758-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-758-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (K562)
hsa-miR-758-3p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-758-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (OVCAR3)
hsa-miR-758-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)
hsa-miR-758-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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