miRTarBase - #MIRT447025


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol FOXD4L1   
Synonyms FOXD5, bA395L14.1
Description forkhead box D4 like 1
Transcript NM_012184   
Expression
Putative miRNA Targets on FOXD4L1
3'UTR of FOXD4L1
(miRNA target sites are highlighted)		 
>FOXD4L1|NM_012184|3'UTR
   1 GCTGACATCGCTGGCTGCCCCTTTGGGCGGAGAGGGGACCTCACCAGTTTTTTTAGTATCGCCCACGCCCAGTTCCCTGG
  81 CCAAGTCCGCAGGGCCCTCCTAGAGCCAGGTGGGAGTGGGGAGCGATCCGCAGCTGCTCACTCCACCTTGCGCGGCCCAT
 161 ACTGGGCGTGTGCATCTGAATCCTGCTGGAGAGCAAACACGAACTTCTGTTCCCTGCAAAATGGTTAGAAAGAAACAGCT
 241 GGATTACGTTCCTCTAAAAACCACCTGAACGTAACCTTCGCAGGGCGTCAAGTCATCTTTTCTTGCCTTCGGCTGTGGCT
 321 TCTGTGGCTTTCCGGATTTGCACATTTCCTGGGGTACTATGAACGTGAGTGGGGTATTTTGTTCTGGCATTAGAAGAAAA
 401 ACAAGCAAGCAAACAAAAACACAGCCTCCGATGCCAAACATGTTCCCCCTTCTTCACTTCCTTGGAACTGGAAGTGTTAT
 481 TCCTAAGTCTAGTGCAAAATGCTTCTACTCTCTGTGTCTTCCTGATAGGGATGTTTAATGTAAGTAGGATATTAATTTCA
 561 GAACATTGATTTCTTATCTGTGTGTCTGACGTGCCATCTTTAATGTTAAAATTAAGGTGTTAAAATTAAGCCTAGTTATA
 641 TAGACGAAATAAAATGCTAAGTCACTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauuUAGAGUAUCACGGAAGa 5'
               ||||: |  ||||||| 
Target 5' aagtcATCTTTTCTTGCCTTCg 3'
 290 - 311 157.00 -11.80
2 
miRNA  3' agaUUUA-GAGUAU------CACGGAAGa 5'
             |||| ||: ||      |||:|||| 
Target 5' gcaAAATGCTTCTACTCTCTGTGTCTTCc 3'
 494 - 522 141.00 -15.10
3 
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            |: :||| |  ||||| || 
Target 5' tgTGTGTCTGA-CGTGCCATCt 3'
 579 - 599 123.00 -10.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26976647 16 COSMIC
COSN26976648 18 COSMIC
COSN31509148 26 COSMIC
COSN31539708 64 COSMIC
COSN30462352 76 COSMIC
COSN30482350 78 COSMIC
COSN30451755 89 COSMIC
COSN30488056 96 COSMIC
COSN30488073 97 COSMIC
COSN30156546 98 COSMIC
COSN30513838 124 COSMIC
COSN30481043 126 COSMIC
COSN30132287 130 COSMIC
COSN31611445 131 COSMIC
COSN26976646 141 COSMIC
COSN26976644 152 COSMIC
COSN30191099 160 COSMIC
COSN26976645 177 COSMIC
COSN30109938 214 COSMIC
COSN15624109 243 COSMIC
COSN26586216 268 COSMIC
COSN28693671 311 COSMIC
COSN6674499 325 COSMIC
COSN26579903 335 COSMIC
COSN26958128 397 COSMIC
COSN31527884 397 COSMIC
COSN19657905 406 COSMIC
COSN9072853 426 COSMIC
COSN30526653 453 COSMIC
COSN14951090 477 COSMIC
COSN30137226 478 COSMIC
COSN31522506 501 COSMIC
COSN30122980 511 COSMIC
COSN31479984 525 COSMIC
COSN24137291 529 COSMIC
COSN30170776 530 COSMIC
COSN30136735 574 COSMIC
COSN8607054 579 COSMIC
COSN23980535 586 COSMIC
COSN30114710 598 COSMIC
COSN31585826 600 COSMIC
COSN30509999 620 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1465145357 3 dbSNP
rs201768703 5 dbSNP
rs778101786 7 dbSNP
rs1431284320 11 dbSNP
rs749494950 12 dbSNP
rs1424126591 13 dbSNP
rs1458048855 16 dbSNP
rs1191736123 17 dbSNP
rs771456686 18 dbSNP
rs1455499427 22 dbSNP
rs1364029218 24 dbSNP
rs200076939 25 dbSNP
rs1299333379 28 dbSNP
rs760135516 29 dbSNP
rs772565502 31 dbSNP
rs766351179 32 dbSNP
rs775857050 35 dbSNP
rs761445044 37 dbSNP
rs764621205 38 dbSNP
rs1356938443 45 dbSNP
rs750106599 46 dbSNP
rs1286606029 47 dbSNP
rs1397873207 48 dbSNP
rs751338655 48 dbSNP
rs181212185 56 dbSNP
rs1310811544 58 dbSNP
rs1300969994 59 dbSNP
rs1302632330 72 dbSNP
rs531622876 73 dbSNP
rs1220337693 82 dbSNP
rs1739556 84 dbSNP
rs1203343794 86 dbSNP
rs1401102360 95 dbSNP
rs551666959 128 dbSNP
rs1464700958 130 dbSNP
rs972095970 133 dbSNP
rs1219277818 137 dbSNP
rs1280362307 143 dbSNP
rs1436321837 152 dbSNP
rs565199934 154 dbSNP
rs761108113 157 dbSNP
rs533313512 160 dbSNP
rs1026327292 162 dbSNP
rs143668791 168 dbSNP
rs774482802 171 dbSNP
rs1238485782 174 dbSNP
rs1459044506 177 dbSNP
rs759535182 184 dbSNP
rs1176648008 185 dbSNP
rs1256198224 200 dbSNP
rs952070692 202 dbSNP
rs1350497177 209 dbSNP
rs550600544 213 dbSNP
rs566142440 214 dbSNP
rs879021348 214 dbSNP
rs1239982711 215 dbSNP
rs1432441019 220 dbSNP
rs566948846 224 dbSNP
rs1469726439 225 dbSNP
rs147516173 227 dbSNP
rs1378777688 238 dbSNP
rs1191833723 249 dbSNP
rs11688758 265 dbSNP
rs535624823 271 dbSNP
rs1427610950 272 dbSNP
rs552667392 287 dbSNP
rs984893528 288 dbSNP
rs1420188068 291 dbSNP
rs1176180613 302 dbSNP
rs1162142069 308 dbSNP
rs763601115 308 dbSNP
rs116543208 311 dbSNP
rs1256501217 312 dbSNP
rs151315373 314 dbSNP
rs1250194491 323 dbSNP
rs2144270 325 dbSNP
rs1486864742 326 dbSNP
rs538068202 331 dbSNP
rs1216549713 334 dbSNP
rs6714080 335 dbSNP
rs1276098831 343 dbSNP
rs1365052950 353 dbSNP
rs538320661 355 dbSNP
rs909688988 359 dbSNP
rs1258491897 360 dbSNP
rs1297296930 360 dbSNP
rs1319687622 365 dbSNP
rs1291711972 366 dbSNP
rs764409178 372 dbSNP
rs1457021535 375 dbSNP
rs1368479704 376 dbSNP
rs1166650976 381 dbSNP
rs1196491299 382 dbSNP
rs577926403 386 dbSNP
rs756922475 388 dbSNP
rs1193446032 389 dbSNP
rs2474236 394 dbSNP
rs533773202 397 dbSNP
rs1452107158 398 dbSNP
rs4849234 406 dbSNP
rs1248471312 410 dbSNP
rs1273843583 417 dbSNP
rs1235389887 430 dbSNP
rs1477175716 433 dbSNP
rs1316344165 443 dbSNP
rs1277768098 444 dbSNP
rs1198925161 445 dbSNP
rs1327966320 446 dbSNP
rs185705270 458 dbSNP
rs975678432 470 dbSNP
rs1390856888 472 dbSNP
rs1327391257 475 dbSNP
rs3982977 477 dbSNP
rs1168968120 484 dbSNP
rs1170938935 485 dbSNP
rs1475955912 490 dbSNP
rs573657795 492 dbSNP
rs1396494971 500 dbSNP
rs1406390571 503 dbSNP
rs1433062120 508 dbSNP
rs1254148939 511 dbSNP
rs1324964846 513 dbSNP
rs1347558419 515 dbSNP
rs1456493572 522 dbSNP
rs922534497 526 dbSNP
rs933907047 527 dbSNP
rs542392864 529 dbSNP
rs562588094 530 dbSNP
rs1277264425 534 dbSNP
rs1232234491 540 dbSNP
rs1371693278 564 dbSNP
rs1305531944 567 dbSNP
rs1444017095 569 dbSNP
rs1375446206 572 dbSNP
rs1356982944 574 dbSNP
rs1411259957 583 dbSNP
rs3982978 586 dbSNP
rs1171238372 592 dbSNP
rs1465824371 597 dbSNP
rs576276244 606 dbSNP
rs1041351990 608 dbSNP
rs1437918293 617 dbSNP
rs924295355 625 dbSNP
rs1221818564 627 dbSNP
rs1264248547 639 dbSNP
rs935731034 642 dbSNP
rs1489389615 646 dbSNP
rs1278112134 647 dbSNP
rs1282407023 662 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000306507.5 | 3UTR | UCAAGUCAUCUUUUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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