miRTarBase - #MIRT447158


—
pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MFSD8   
Synonyms CCMD, CLN7
Description major facilitator superfamily domain containing 8
Transcript NM_152778   
Expression
Putative miRNA Targets on MFSD8
3'UTR of MFSD8
(miRNA target sites are highlighted)		 
>MFSD8|NM_152778|3'UTR
   1 ACTAGCTAAGACTGTGATGGAAACTACTTGCTGTGTGGCACTTCCTGGTCTAAAGCTCTGCTAGACAATTGCGGTGAGCC
  81 AGTCTCCAAGAATCAGACTACAGATATTGCAGATTTTGAAGAACAAGAACATATGTTGAATAACAGAGAGAATTCTACAT
 161 GTCATTGTGAATAGTAGGTTATATAAAAACATACTAGATGATAATTTCCTTACCTCAGAAATGAAATATTATTCTTATAA
 241 TACCTTTTTGTGGTTGCATGAACTAATGAGTGAATGGACAATGATGAATAAATGTGAAGCTGTATTCTTAATACCCACTG
 321 CAGAAGTGTCATTAAAATAATATACAGTGGAACCAGAAAGAGGGTTCTGTAAGAATTAGCCATAGCAGAACAAAATTATA
 401 GAATTTTAAATACCTCTACCCAAGTAGAGGTATTTTTATTCAGACACCTACTTTTTATTTATAAAAAAATGCATTTTCTA
 481 TTATCAAGTTCACTTATGAAATAAAAATTATAACACATATTTTCCATTTAGCGTGCCTAACATCCTACCTTGCCTTCTAT
 561 GAGTCTTTCTTCTAATACTACACCTCTGCCTTATTTTAGTTCAGGGTTTCACTAAGTAACCCCTACATTAATAAATGAGT
 641 ATGGATAATGCTAATATTTGAGCAATACAGAGGATTAAGAGATCAAGATACTTCACTGCCTATTAGCCTAATAGGGATAC
 721 CTACTTTCTTTCAAATGCCAAAAATTCACATTAGAAACATAATCCAGATATGTGTTATTTTATATATATATATACAAAAC
 801 AGTAAATGGTTTCTTAAAATTATTGCTATTTTTCAACCCCCTTAAACTGGAGAAAAACATTTAATTAGTAAAACATTAAT
 881 TAATTTACTTTAATTTTTCCCATCTCTCAGTAGTGGCGGGGAGGAACACAACAGTTTTCAATCTATGTCTGCATAGTTGT
 961 GTAGAGCTGCAGAATTTTAGTTGGATTTTTAATTTGGATGATCCCTGACAGCCCCAAACTAGTCAGGCTAATAAGTATTT
1041 GAGGCAAAATGGCTTTAATCTAACAATTTACTGAGTTTACCTGAAGTTGGCTAAATAACACTGTATGTTTAACTTCTACC
1121 TCTACATAAGTTGAATGCTGATAAAAGGAACTAGTAGATAACTATGTATATTGATAAGCACTGTTAAGAAAATGCAAAAA
1201 TATTTCTAAACACTTTTCCAAATGTTTTCTACTTTAAGTTAGAAATAGTTTCAAATCTGAGAATAAACACTATATAATCT
1281 GCACTTTATAGGTTGGGTGCAGTGTCTCATGCCTGTAATCCCAGCACTTTGGAAGGCCAAGGCAGGAGGATTGCTTGAGG
1361 CCAGGAATTCAAGACCAGCCTGGGAAACAAAGTGAGACCCTGTCTTTACAAAAAATAAAAACAAAAATTTAAAACTGTAT
1441 AATCTGCACTTTATGCTAAACTAGCTGTGCTCTTAAACTCAATTTTTTCAGCTCTAATAAAGGGCTTAATTTGATAGAAT
1521 TATTCTACGATTAAATTTTGAAGACTGTTTTCACTCTCCTCTGCCGCCCATAGCAAGACTGCTTCCATAGATTTCTCAGA
1601 ACCGTAGCCAGTTCTGGCTATTTGGTCAAGTCTGGGATCCCTCTTACCTGCTATTCTGCAGCTGCTTTCTCTGTCTTACA
1681 TTTTTTGGGCCACGTCTAATCTTAAAGAGTAAACTCTACCCTTGGTTTGCATAGTGTGCATGACAAAAATAACAAGAATA
1761 ATGGTAATGATGAAAATGATAAGAGCAAAATTTGTGGAGTGCTTTCCACATTCCAGGTAATGTGTAACATACAATTTAAT
1841 TCTTACAGCAGTCTTATGGAGTGAAAATACTATTATGATTCCCGTTTTACAGATGAAAGAATGGAGGCACAGAAAAGTTA
1921 CTTGTCTAAGTAACAGTCTATCCTTAAAGTCCACAGTCTTAACCACTTGATTTTTCATAGTGAGGAAAATATCCCAGAAA
2001 GTTGCAGTTTCAATTAATCACTAATTGTAGGGTAATTTAACTATACCAGTGAGTCCTACTAGCAGAAATATTTGGGCAAC
2081 ATAAGCCCACTGACTGGAGCTTTTGTCTTAGCATAATAACCTGTTTCCAGCAAGAATATAACAGAAAAAAGTTTCCCAGC
2161 TTTCAAAGGTTTATAATATTGATTAAAATTTAGATAAACTTAACCTTACACAAATGACTCTTACTTTCCTTTTTATTGAG
2241 AGCATTTTCTTTGGAGCATTTTCTTCTTTGGAGGATTATACCTTGCTCATCTTGGCACAAAAGAAGGCGAAAGGAAGTAA
2321 CATGGGATTGGGAAAAGAGCAAGGAGATAAAGTTTGAGGAAAAAAAATCACCATGTTGATGTCTTCTTGAGTAGGCCAAG
2401 TTGCGTATAAAGAGAAAATGACAACAGGAGATTTTAAGGTATGATATATTGTTAAGAGTAGTACATATTTAAGAAGAGAA
2481 AATATGTTTTTGAAAACAAATTTAAACTTGAAAGGATGATTTTCATATTTTGAAGGGATTTATAACTTCACAAAGCATCT
2561 CCATTCTATCTTGTTCAGCTTTACATTTAAAAATAAACTCTTCTTGTTCATATAAACCTTATCTCTTACATAAAGTGAAA
2641 TCTGTTAATTTTTTGTTTTGACAAGGATAAACTACTTACCTGCATCTGTTTAAGAATAGATTAACTTATTTTGAGAAGAA
2721 ATTCTGGGCACCATTTTTGACCATTGAAGACTTATTTGTAATTTAATTTCTACTTTACATTGTGAATGTTCATTTTCTAA
2801 TAAACAAGATTATTTTGCATATGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cggUCGAUUGUUAU---GUGACGGa 5'
             || | | :|||   ||||||| 
Target 5' aagAGATCAAGATACTTCACTGCCt 3'
 677 - 701 155.00 -14.00
2 
miRNA  3' cggUCGAU-U----GUUAU--GUGACGga 5'
             ||||: |    :||||  ||||||  
Target 5' tgaAGCTGTATTCTTAATACCCACTGCag 3'
 295 - 323 135.00 -12.90
3 
miRNA  3' cggUCGAUUG--UUA-UGUGACGga 5'
             ||:|::|  ||| ||||||:  
Target 5' tgaAGTTGGCTAAATAACACTGTat 3'
 1082 - 1106 129.00 -15.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
347539 208 ClinVar
902744 250 ClinVar
347538 258 ClinVar
902743 369 ClinVar
347537 414 ClinVar
902742 427 ClinVar
347536 463 ClinVar
347535 470 ClinVar
347534 492 ClinVar
347533 533 ClinVar
901838 675 ClinVar
347532 695 ClinVar
901837 734 ClinVar
347531 839 ClinVar
901836 842 ClinVar
347530 1058 ClinVar
901835 1147 ClinVar
347529 1161 ClinVar
901229 1280 ClinVar
901228 1455 ClinVar
347528 1471 ClinVar
347527 1515 ClinVar
347526 1603 ClinVar
901227 1680 ClinVar
901226 1709 ClinVar
347525 1794 ClinVar
900126 1918 ClinVar
900125 1969 ClinVar
900124 2006 ClinVar
900123 2010 ClinVar
900122 2021 ClinVar
900121 2104 ClinVar
900120 2146 ClinVar
347524 2214 ClinVar
347523 2270 ClinVar
902672 2294 ClinVar
902671 2309 ClinVar
902670 2314 ClinVar
902669 2369 ClinVar
347522 2387 ClinVar
347521 2405 ClinVar
902668 2464 ClinVar
347520 2465 ClinVar
901765 2592 ClinVar
347519 2613 ClinVar
347518 2683 ClinVar
347517 2689 ClinVar
COSN26572819 10 COSMIC
COSN30193237 25 COSMIC
COSN30491960 37 COSMIC
COSN31510284 41 COSMIC
COSN30502523 48 COSMIC
COSN31569584 103 COSMIC
COSN30515819 104 COSMIC
COSN30107473 135 COSMIC
COSN31601673 155 COSMIC
COSN28003261 462 COSMIC
COSN28202074 612 COSMIC
COSN27184307 780 COSMIC
COSN14880628 825 COSMIC
COSN26700622 1394 COSMIC
COSN4825763 1597 COSMIC
COSN6797125 1740 COSMIC
COSN25814029 2122 COSMIC
COSN7731499 2309 COSMIC
COSN28198109 2315 COSMIC
COSN5552284 2708 COSMIC
COSN22619672 2770 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs753071746 1 dbSNP
rs374487025 3 dbSNP
rs1279416280 13 dbSNP
rs766561103 23 dbSNP
rs1366300372 29 dbSNP
rs751643210 33 dbSNP
rs766600653 38 dbSNP
rs1438240483 39 dbSNP
rs763024313 44 dbSNP
rs1388160277 45 dbSNP
rs750641784 46 dbSNP
rs1463977412 47 dbSNP
rs765439882 48 dbSNP
rs1171336162 50 dbSNP
rs758618906 56 dbSNP
rs1381539136 66 dbSNP
rs545096620 70 dbSNP
rs1157162778 72 dbSNP
rs1422078019 72 dbSNP
rs1033247695 73 dbSNP
rs986145964 74 dbSNP
rs1015279706 82 dbSNP
rs1368469824 96 dbSNP
rs1446740220 97 dbSNP
rs1280049868 101 dbSNP
rs185907899 106 dbSNP
rs1237870982 110 dbSNP
rs1029815022 118 dbSNP
rs1348351106 120 dbSNP
rs1029455038 122 dbSNP
rs1281041402 130 dbSNP
rs996976943 130 dbSNP
rs1209439323 131 dbSNP
rs1256575281 133 dbSNP
rs1177339072 141 dbSNP
rs1182593055 146 dbSNP
rs1380056670 150 dbSNP
rs1478586628 151 dbSNP
rs900004748 156 dbSNP
rs750538987 160 dbSNP
rs1399692936 165 dbSNP
rs1413565543 173 dbSNP
rs1331347160 178 dbSNP
rs1044339654 181 dbSNP
rs892733896 196 dbSNP
rs947007627 196 dbSNP
rs1371422293 200 dbSNP
rs886059069 208 dbSNP
rs1235225483 226 dbSNP
rs901560862 228 dbSNP
rs1015119810 233 dbSNP
rs939389331 234 dbSNP
rs1218898639 237 dbSNP
rs928051610 238 dbSNP
rs1459186509 239 dbSNP
rs1197271313 248 dbSNP
rs980825570 250 dbSNP
rs948523555 256 dbSNP
rs151190415 258 dbSNP
rs1332917671 272 dbSNP
rs1293115856 293 dbSNP
rs974376227 294 dbSNP
rs1170971539 296 dbSNP
rs962641833 326 dbSNP
rs1229385861 328 dbSNP
rs1015958603 343 dbSNP
rs1391433923 347 dbSNP
rs887462492 350 dbSNP
rs1330325706 363 dbSNP
rs1436001629 364 dbSNP
rs534031511 369 dbSNP
rs1391259364 381 dbSNP
rs1001377626 382 dbSNP
rs1216944624 387 dbSNP
rs1257523337 389 dbSNP
rs905805418 396 dbSNP
rs1390850705 398 dbSNP
rs1265647338 401 dbSNP
rs566768714 414 dbSNP
rs1451440293 419 dbSNP
rs949922467 423 dbSNP
rs142139835 427 dbSNP
rs1459579567 429 dbSNP
rs1264964828 433 dbSNP
rs1476547061 436 dbSNP
rs1416686651 438 dbSNP
rs1169261678 448 dbSNP
rs1368572334 450 dbSNP
rs1159704302 452 dbSNP
rs1161443165 457 dbSNP
rs1389713618 462 dbSNP
rs181696565 463 dbSNP
rs1299022264 469 dbSNP
rs1342549121 470 dbSNP
rs1398385946 470 dbSNP
rs746048384 470 dbSNP
rs1341164273 474 dbSNP
rs1022442141 485 dbSNP
rs1264242500 487 dbSNP
rs1356084741 488 dbSNP
rs936003817 490 dbSNP
rs534206104 492 dbSNP
rs550623161 495 dbSNP
rs1487081928 497 dbSNP
rs1192512634 500 dbSNP
rs1256218325 502 dbSNP
rs1452069579 502 dbSNP
rs1268196458 513 dbSNP
rs1215615650 516 dbSNP
rs954239924 519 dbSNP
rs1367882016 521 dbSNP
rs556727493 522 dbSNP
rs1052675651 527 dbSNP
rs922859695 532 dbSNP
rs11940642 533 dbSNP
rs1418039213 540 dbSNP
rs1288559709 545 dbSNP
rs961574776 547 dbSNP
rs906553010 559 dbSNP
rs1382615113 562 dbSNP
rs1241511607 564 dbSNP
rs1045101191 572 dbSNP
rs1352027168 574 dbSNP
rs1238992578 583 dbSNP
rs1256296359 589 dbSNP
rs1483940642 594 dbSNP
rs1014655179 613 dbSNP
rs948182054 640 dbSNP
rs1332146655 647 dbSNP
rs920702309 672 dbSNP
rs148636320 675 dbSNP
rs951841775 679 dbSNP
rs1438894146 687 dbSNP
rs886059068 695 dbSNP
rs1393358784 713 dbSNP
rs1467787249 721 dbSNP
rs1301095179 725 dbSNP
rs1405470574 726 dbSNP
rs1320813170 727 dbSNP
rs530078817 733 dbSNP
rs1027710245 734 dbSNP
rs1223640010 739 dbSNP
rs1302431962 748 dbSNP
rs1313522474 750 dbSNP
rs1230652268 761 dbSNP
rs1261910972 768 dbSNP
rs1382553024 769 dbSNP
rs1001157378 771 dbSNP
rs908417410 776 dbSNP
rs767509484 780 dbSNP
rs1457143386 782 dbSNP
rs1045665639 783 dbSNP
rs1269207238 789 dbSNP
rs545729393 792 dbSNP
rs1478343831 793 dbSNP
rs1014025587 795 dbSNP
rs1428649603 795 dbSNP
rs774144170 795 dbSNP
rs869279774 795 dbSNP
rs954995447 797 dbSNP
rs891652290 800 dbSNP
rs546184664 807 dbSNP
rs886059067 839 dbSNP
rs1029351583 840 dbSNP
rs975098695 841 dbSNP
rs1384690743 842 dbSNP
rs1195654189 850 dbSNP
rs1052972092 858 dbSNP
rs528798972 871 dbSNP
rs1317993429 880 dbSNP
rs936062141 892 dbSNP
rs1022497990 899 dbSNP
rs1216797697 901 dbSNP
rs926064117 910 dbSNP
rs1049724436 917 dbSNP
rs561229523 918 dbSNP
rs957095758 919 dbSNP
rs980255596 922 dbSNP
rs922845078 923 dbSNP
rs969792335 925 dbSNP
rs977023799 931 dbSNP
rs916906673 939 dbSNP
rs961522858 941 dbSNP
rs1283083593 945 dbSNP
rs908673176 946 dbSNP
rs1232652754 960 dbSNP
rs1369641588 981 dbSNP
rs1409851571 1000 dbSNP
rs549337295 1015 dbSNP
rs1166165385 1016 dbSNP
rs1297646007 1022 dbSNP
rs1351950011 1035 dbSNP
rs1432510062 1038 dbSNP
rs984323512 1042 dbSNP
rs1003765296 1043 dbSNP
rs1317453233 1054 dbSNP
rs531103173 1058 dbSNP
rs1027413438 1062 dbSNP
rs1012693405 1064 dbSNP
rs899243226 1077 dbSNP
rs1001155379 1091 dbSNP
rs1319690956 1095 dbSNP
rs546846597 1101 dbSNP
rs1221388896 1106 dbSNP
rs1286483573 1107 dbSNP
rs969720662 1126 dbSNP
rs941166907 1136 dbSNP
rs1240404496 1137 dbSNP
rs532156248 1138 dbSNP
rs1024163154 1142 dbSNP
rs189901544 1147 dbSNP
rs1394587130 1151 dbSNP
rs767418097 1161 dbSNP
rs1031885392 1165 dbSNP
rs1163261646 1179 dbSNP
rs545446816 1181 dbSNP
rs1361607281 1183 dbSNP
rs1421088618 1187 dbSNP
rs1296005379 1190 dbSNP
rs1187147666 1191 dbSNP
rs1476539057 1193 dbSNP
rs1448197316 1201 dbSNP
rs1000042677 1210 dbSNP
rs1240561332 1213 dbSNP
rs904599798 1222 dbSNP
rs1245195388 1236 dbSNP
rs1309657411 1238 dbSNP
rs1049877493 1245 dbSNP
rs1242538083 1249 dbSNP
rs932618765 1251 dbSNP
rs901200912 1259 dbSNP
rs1282840384 1269 dbSNP
rs528393181 1272 dbSNP
rs1210833015 1275 dbSNP
rs1239288926 1277 dbSNP
rs146441639 1280 dbSNP
rs975098313 1281 dbSNP
rs1156434417 1288 dbSNP
rs940242803 1290 dbSNP
rs76614198 1294 dbSNP
rs908796724 1299 dbSNP
rs1414688951 1302 dbSNP
rs914957956 1304 dbSNP
rs1356957192 1309 dbSNP
rs984660574 1309 dbSNP
rs1274798751 1311 dbSNP
rs931531621 1317 dbSNP
rs377013243 1334 dbSNP
rs1378826415 1346 dbSNP
rs1237759397 1347 dbSNP
rs1215799890 1363 dbSNP
rs543269935 1365 dbSNP
rs1350140266 1370 dbSNP
rs1269238136 1372 dbSNP
rs1220064287 1373 dbSNP
rs920327031 1387 dbSNP
rs1321565288 1396 dbSNP
rs754926849 1402 dbSNP
rs1203582800 1416 dbSNP
rs1310803235 1421 dbSNP
rs1459492154 1428 dbSNP
rs1180026873 1433 dbSNP
rs770554417 1437 dbSNP
rs1003691950 1444 dbSNP
rs979851286 1455 dbSNP
rs1414132651 1464 dbSNP
rs969794066 1466 dbSNP
rs1023902538 1467 dbSNP
rs886059066 1471 dbSNP
rs1171280011 1472 dbSNP
rs1402294580 1482 dbSNP
rs1389608270 1488 dbSNP
rs1327892324 1491 dbSNP
rs74590222 1515 dbSNP
rs1437430127 1517 dbSNP
rs541428629 1529 dbSNP
rs1417386099 1531 dbSNP
rs1343703667 1538 dbSNP
rs1167568191 1542 dbSNP
rs1484937391 1552 dbSNP
rs1475629702 1557 dbSNP
rs1012208631 1558 dbSNP
rs1260105646 1563 dbSNP
rs113242138 1565 dbSNP
rs554828236 1566 dbSNP
rs1452584849 1570 dbSNP
rs1233965276 1573 dbSNP
rs1207164930 1575 dbSNP
rs1479915705 1581 dbSNP
rs904378270 1588 dbSNP
rs536079775 1603 dbSNP
rs139066500 1604 dbSNP
rs374830589 1608 dbSNP
rs1460360289 1611 dbSNP
rs1167313650 1615 dbSNP
rs1271623378 1619 dbSNP
rs146398570 1620 dbSNP
rs1301078924 1622 dbSNP
rs538771514 1625 dbSNP
rs1404600329 1626 dbSNP
rs1291259524 1630 dbSNP
rs1278866718 1633 dbSNP
rs901274379 1633 dbSNP
rs1041027966 1634 dbSNP
rs940045085 1637 dbSNP
rs1351101203 1641 dbSNP
rs574434155 1643 dbSNP
rs1225831832 1644 dbSNP
rs887348597 1645 dbSNP
rs1439859234 1675 dbSNP
rs1357485529 1678 dbSNP
rs1211949052 1679 dbSNP
rs1048664726 1680 dbSNP
rs931461516 1681 dbSNP
rs942347908 1685 dbSNP
rs1462208796 1687 dbSNP
rs914905281 1693 dbSNP
rs149424676 1694 dbSNP
rs989223654 1721 dbSNP
rs1420279375 1726 dbSNP
rs370726249 1733 dbSNP
rs546222500 1736 dbSNP
rs956440047 1740 dbSNP
rs923722618 1745 dbSNP
rs1163311211 1753 dbSNP
rs1364756372 1757 dbSNP
rs1475089378 1767 dbSNP
rs1424231224 1773 dbSNP
rs1409102393 1776 dbSNP
rs982240753 1785 dbSNP
rs1387223630 1790 dbSNP
rs79783621 1794 dbSNP
rs1317743872 1807 dbSNP
rs1023883728 1809 dbSNP
rs1231848193 1812 dbSNP
rs566860446 1829 dbSNP
rs549615698 1830 dbSNP
rs1359237349 1836 dbSNP
rs1240383631 1845 dbSNP
rs980925058 1847 dbSNP
rs186704095 1854 dbSNP
rs1469579468 1862 dbSNP
rs1203968913 1867 dbSNP
rs1270875725 1870 dbSNP
rs1212604609 1876 dbSNP
rs917007750 1883 dbSNP
rs747618421 1884 dbSNP
rs1181728308 1887 dbSNP
rs1308815023 1894 dbSNP
rs1384342955 1910 dbSNP
rs1004898859 1911 dbSNP
rs1159456742 1917 dbSNP
rs1222036034 1917 dbSNP
rs886490178 1921 dbSNP
rs1030422942 1934 dbSNP
rs781681702 1940 dbSNP
rs1403033591 1945 dbSNP
rs1372500359 1955 dbSNP
rs547746685 1969 dbSNP
rs755457050 1972 dbSNP
rs751076278 1987 dbSNP
rs1441729997 1996 dbSNP
rs1031986462 1998 dbSNP
rs181240021 2006 dbSNP
rs968633203 2011 dbSNP
rs1314721598 2017 dbSNP
rs1237903869 2019 dbSNP
rs780466040 2021 dbSNP
rs533507894 2028 dbSNP
rs1461077751 2030 dbSNP
rs1346555001 2044 dbSNP
rs996684472 2047 dbSNP
rs1242514611 2052 dbSNP
rs1458172184 2055 dbSNP
rs1346196376 2056 dbSNP
rs1248191821 2058 dbSNP
rs965419600 2074 dbSNP
rs1019743427 2076 dbSNP
rs893740957 2081 dbSNP
rs559872777 2084 dbSNP
rs1004617454 2092 dbSNP
rs1053833753 2093 dbSNP
rs1161689488 2098 dbSNP
rs188459520 2099 dbSNP
rs139930263 2104 dbSNP
rs935003893 2112 dbSNP
rs1300213171 2113 dbSNP
rs995750508 2121 dbSNP
rs758609347 2123 dbSNP
rs1301621047 2131 dbSNP
rs561042544 2132 dbSNP
rs1346828268 2134 dbSNP
rs949544303 2138 dbSNP
rs750676275 2146 dbSNP
rs1192642033 2151 dbSNP
rs1261975648 2152 dbSNP
rs183601926 2154 dbSNP
rs575446062 2166 dbSNP
rs1249383731 2169 dbSNP
rs949591563 2175 dbSNP
rs1176834628 2185 dbSNP
rs963937026 2189 dbSNP
rs1481550064 2196 dbSNP
rs1428709735 2204 dbSNP
rs147020536 2204 dbSNP
rs200765897 2205 dbSNP
rs983411960 2205 dbSNP
rs916996324 2210 dbSNP
rs886059065 2214 dbSNP
rs60807717 2218 dbSNP
rs1294498962 2222 dbSNP
rs1366984439 2225 dbSNP
rs757432661 2227 dbSNP
rs1280961014 2235 dbSNP
rs934306144 2252 dbSNP
rs886059064 2270 dbSNP
rs1373319458 2276 dbSNP
rs924270202 2294 dbSNP
rs1293433267 2295 dbSNP
rs978850732 2303 dbSNP
rs968582711 2308 dbSNP
rs753944036 2309 dbSNP
rs1386466120 2314 dbSNP
rs1490887872 2315 dbSNP
rs181941949 2322 dbSNP
rs767601206 2323 dbSNP
rs1053709945 2328 dbSNP
rs1452072234 2347 dbSNP
rs1417916878 2352 dbSNP
rs1238691371 2360 dbSNP
rs1428442847 2360 dbSNP
rs150664430 2369 dbSNP
rs1174828803 2371 dbSNP
rs1437070988 2375 dbSNP
rs1360603251 2386 dbSNP
rs143272176 2387 dbSNP
rs1172439937 2388 dbSNP
rs1286625515 2390 dbSNP
rs1361105791 2393 dbSNP
rs1428809721 2398 dbSNP
rs552620239 2404 dbSNP
rs11938181 2405 dbSNP
rs566884189 2407 dbSNP
rs1244049079 2410 dbSNP
rs902219529 2415 dbSNP
rs1046115555 2419 dbSNP
rs951564840 2422 dbSNP
rs141923297 2430 dbSNP
rs1240458271 2439 dbSNP
rs1345608243 2442 dbSNP
rs916346736 2444 dbSNP
rs1184807654 2447 dbSNP
rs995922829 2457 dbSNP
rs1245325863 2459 dbSNP
rs1443243962 2463 dbSNP
rs114689638 2464 dbSNP
rs72616968 2465 dbSNP
rs1402090122 2468 dbSNP
rs909452116 2477 dbSNP
rs551985948 2483 dbSNP
rs1013690723 2485 dbSNP
rs1448627979 2510 dbSNP
rs1380685497 2512 dbSNP
rs1340317537 2515 dbSNP
rs950682143 2517 dbSNP
rs923289749 2525 dbSNP
rs1451569001 2527 dbSNP
rs896685516 2532 dbSNP
rs976098485 2542 dbSNP
rs1417204525 2550 dbSNP
rs1053044217 2553 dbSNP
rs965126787 2555 dbSNP
rs934402967 2556 dbSNP
rs1282223827 2567 dbSNP
rs1017694396 2584 dbSNP
rs924357088 2592 dbSNP
rs1204863979 2593 dbSNP
rs1171556880 2604 dbSNP
rs762152762 2606 dbSNP
rs1374237682 2609 dbSNP
rs539367239 2613 dbSNP
rs1427517750 2621 dbSNP
rs1470946363 2635 dbSNP
rs1175159898 2642 dbSNP
rs138394198 2658 dbSNP
rs1418363405 2659 dbSNP
rs1469919553 2660 dbSNP
rs1177981308 2665 dbSNP
rs947069040 2666 dbSNP
rs921179024 2674 dbSNP
rs975351204 2676 dbSNP
rs570383556 2680 dbSNP
rs886059063 2683 dbSNP
rs1444600765 2688 dbSNP
rs189321020 2689 dbSNP
rs1372686528 2697 dbSNP
rs1224138959 2709 dbSNP
rs562157927 2711 dbSNP
rs543441899 2713 dbSNP
rs1027520061 2731 dbSNP
rs1203639171 2732 dbSNP
rs530866812 2749 dbSNP
rs1274113940 2755 dbSNP
rs1253102169 2762 dbSNP
rs563411388 2777 dbSNP
rs563416429 2779 dbSNP
rs894848416 2780 dbSNP
rs766209739 2782 dbSNP
rs1200905205 2783 dbSNP
rs1054921215 2785 dbSNP
rs1480058703 2804 dbSNP
rs1294341389 2808 dbSNP
rs969386573 2817 dbSNP
rs942185739 2818 dbSNP
rs1398365765 2819 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggucgaUUGUUAUGUGACgga 5'
                 :|:| | |||||   
Target 5' ---ucaaGAUACUUCACUG--- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000296468.3 | 3UTR | UCAAGAUACUUCACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.334 3.5e-3 -0.455 7.9e-5 64 Click to see details
GSE28260 Renal cortex and medulla 0.695 4.2e-3 0.676 5.6e-3 13 Click to see details
GSE28544 Breast cancer -0.512 5.3e-3 -0.334 5.5e-2 24 Click to see details
GSE19350 CNS germ cell tumors -0.522 4.1e-2 -0.070 4.1e-1 12 Click to see details
GSE17306 Multiple myeloma 0.248 4.3e-2 0.293 2.1e-2 49 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.612 5.3e-2 0.738 1.8e-2 8 Click to see details
GSE38226 Liver fibrosis 0.309 8.6e-2 0.219 1.7e-1 21 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.164 2.2e-1 0.010 4.8e-1 25 Click to see details
GSE27834 Pluripotent stem cells -0.209 2.2e-1 -0.082 3.8e-1 16 Click to see details
GSE21849 B cell lymphoma -0.134 2.4e-1 -0.187 1.7e-1 29 Click to see details
GSE19536 Breast cancer -0.059 2.8e-1 -0.053 3.0e-1 100 Click to see details
GSE32688 Pancreatic cancer 0.106 2.8e-1 0.159 1.9e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.114 2.9e-1 -0.025 4.5e-1 25 Click to see details
GSE19783 ER- ER- breast cancer -0.041 3.6e-1 -0.069 2.7e-1 79 Click to see details
GSE26953 Aortic valvular endothelial cells 0.056 4.0e-1 -0.110 3.0e-1 24 Click to see details
GSE19783 ER+ ER+ breast cancer 0.045 4.3e-1 0.152 2.6e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.033 4.5e-1 -0.558 5.3e-3 20 Click to see details
GSE14794 Lymphoblastoid cells -0.003 4.9e-1 0.044 3.4e-1 90 Click to see details
GSE42095 Differentiated embryonic stem cells -0.001 5.0e-1 -0.080 3.6e-1 23 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.658 0.17 -0.400 0.3 4 Click to see details
THCA 0.499 0.33 0.500 0.33 3 Click to see details
UCEC 0.064 0.44 -0.214 0.31 8 Click to see details
BRCA 0.074 0.46 0.000 0.5 4 Click to see details
BRCA 0.074 0.46 0.000 0.5 4 Click to see details
BRCA 0.074 0.46 0.000 0.5 4 Click to see details
BRCA 0.074 0.46 0.000 0.5 4 Click to see details
BRCA 0.074 0.46 0.000 0.5 4 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission