miRTarBase - #MIRT448014


—
pre-miRNA Information
pre-miRNA hsa-mir-4653   
Genomic Coordinates chr7: 101159473 - 101159555
Description Homo sapiens miR-4653 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4653-5p
Sequence 10| UCUCUGAGCAAGGCUUAACACC |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs566953516 2 dbSNP
rs1307365749 4 dbSNP
rs1226652366 6 dbSNP
rs1216592229 12 dbSNP
rs1283699546 15 dbSNP
rs934609749 20 dbSNP
rs1377199291 21 dbSNP
rs1282994534 22 dbSNP
Putative Targets

Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B8DF7B miR-4653 Predictive Biomarker (PRD) Transcriptomic Data . . . .
Gene Information
Gene Symbol HLA-DOA   
Synonyms HLA-DNA, HLA-DZA, HLADZ
Description major histocompatibility complex, class II, DO alpha
Transcript NM_002119   
Expression
Putative miRNA Targets on HLA-DOA
3'UTR of HLA-DOA
(miRNA target sites are highlighted)		 
>HLA-DOA|NM_002119|3'UTR
   1 TGATCCTTCTGAGAGAAATGACTTGTGGGAGACACCCTGCAGATCCTCATGGGTTTGTGACAGCCCCTGCGTGCTCAGTG
  81 CCCTTTAAGTGCATCCCGCTGTGCTGACTTTGAGTGGGATCAACATCTGTCCTACGGGTCCCCTCTTTTTTGGCCCCAGT
 161 ATTCATGGCAGGGTTTGTTGGACACCTACTAGCTTCCCTTCCCATTCAACACACACACACATTCTTGCTCTACCCAAAGC
 241 TCTGGCTGGCAGCACTAAATGCTTTGGTGGTGTTTGCACTGTGTCCTTTCCAGGCCTTGGCCAGTTCTTCCAGGGGTGAG
 321 GCATGTGGTGCTGGGGATTGGCAGCCATCCTGGGGCCCACACAGGTGTGTCTTGCTCCATTTGGCCCATTGTGTGTTACT
 401 TTGTGAATGAGCCATTTCACATGGACTTCATGAAATTTGCCTCCTGAGTTCAGGTTTACCCTGAAAGGGATGCAGATTAT
 481 CCTGTTCCTCACGACCCCCTCAGCTAACAACAGTTCTGAAGGGTGCTGGGACAGGACAGGCTCATGGGGACTCCACTCCT
 561 GCCTGGGTTTACTCTGTATGAAGAGGCCACTGGTATCCTGCCATGATGTTATCTCCTTTTTCTACTTTTCCCTAGAGTCC
 641 CATGCATGATAAAGAGAGGCCCAAGGCTTGGATAAGGTGGCCACTTCCCTCAGTGGAGTCAGTCATGTTAGGTAGGAGGT
 721 GGTAGAGTCGGTCTGCGAGGTATCTCGTAAGAGGGGAGGTCCACCTAGACACACTCTAAATATGTGGCCTAGAAGATTTT
 801 GGTCTACTTTTCTGTGAACAGAATTTAAAACATACAAAGAGATAAATCACCATACCACATAGTTTATGTCAGGACCAAAA
 881 TGAGCAATACAGATTACGGTTTTCAAACCAGAATGCACATAAGAACTGCTTGGGATCCTTTTAAAAGTACAGGCATTGGC
 961 CTGGTGCAGTGGCTCATTCCTGTAATCCCAGCACTTTGGGAGGCCAAGGGGACAGGACTGCTTGAGGCCAAGAGGTGGAA
1041 ACCATCTTGGGCTACATAGAGAGACCCCATCTCTACAAAGAAAGATTTAAAAATTAACCAGGCATGGTGGCTCGCACCTG
1121 TATTCCCAGCCACTGGGGAGGCTGAGGCCGGAGGAGTGCTTGAGCCCAGGAGTTCAAGGCTGCAGTGAGCCAAGATTGCG
1201 CCACTGCACTCCAGCCTAGGTGACAGAGTGAGACCCTGTCTCTAAATAAATAAATAAATAAAATATAAAAATAACAGTCA
1281 TCACCCAGACCTACTGAATTAGAATCTCGGGAGTGCAGGGGGCAGCAACAGGGAGGCTGTCTTTTCTGAGATGGGGTCTC
1361 ACTCTGTCACCAGGCTGGAGTGCCATGGCATGATCTCAGCTCACTGCAACCTCCACCTCCTGAGTTCAAGCCATTCTCCT
1441 GCCTCAGCCTCCTGAGTAGCTGGGACTACAGGTGTGCGCCACTACACTCAGCTAATTTTTGTATTTTAAGTAGAGACGGG
1521 GTTTCATCATGTTGGCCAGGATGGCCTCCATCTCTTGACCTCGTGATCCACCCACCTTCCCTCCCAAAGTACTGGAATTA
1601 CAGGCATTAGCCACTGTGCCCAGCCGAGGCTGTCATTTTTAACCGGCTCTGGATGACTCTGATGCAGCCATCCTGGACCT
1681 TGGCTGTGGTCTGGTAACTGGAACCCAGTGACGTAATCAGGTGCCATCGGGGGTCATGGGAAAGGGGGATCCCCAAGGTC
1761 TGAGGTGGACTAGGAAGGCTTTCTGAAGAACCTGGGTCTGTTAGGGCATCAGCCAATCAAGGTACAAGTAAATAGAGGCA
1841 AAATGAGGGTTTGAACTGTGAGCAGTTGGTCCTGGAAAAGAAAGAAACCAAGAGATTATGGGGACTCAATGGGCTTCTTA
1921 AGAGAGAATAAGTTGAAATCAATGACCAGAAGACCCTGATGGAAGTGGAGGAGAATCATCTCAGGCAAACTTTTTGTGTG
2001 CCAGTAACAGAAACCCTCTTTGTGTGATCACATGCAAAGTATAGGATATTTGCAATATAGCCATGGGGAGGAGTGCAGGG
2081 CCCAAGGGTAGATTTTAGCCAGGCCTCCCAGGAACAGAACTCGGATCCGAAAAGCCCAGAGAAGCTAGAGCTGCCCCTCC
2161 AACACTCTCGGATCCACATGGTCTGTGTTCTCTAGACCCCCCTGCATGTTAGCGGTGTTCTCTCTCTGTGGACTGACTGT
2241 CCTTCTCAGTGAACATGTCCACCCGACAGCTCCTGAGTTTATATCATCTCAACCCTCACAACCCACAGAGGCTGTGTCTC
2321 CTAGTCACAGCTTTAAATTACTGGAAAAATAAATGACTGGCCAAACTTGGAGCAGGTGTCCATCCCAGCCCTGTGTAGTT
2401 AGAGCAGGAATCAAGATCTCAACACAAATGTGGCTGCCAAGCACTCAGCCCCGGGGCGAGGGGTCAAGTTCTTCTCAGAG
2481 AAAGAGGAATAAGTTGGTTCTCAGAAGACATCACAAGATACGTGTGTACCCAACAATCTCTGATCTCTGCTGATCTTTTG
2561 CTTAGACGTTAACTTGATGCATCATTGGAAAGGTGTTTCTCTCATCTCTGTCCTAAGGCTTGATAAAGTCATTAAAATTG
2641 TGTTCTTTTGACTAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ccaCAAUUCGGAACGAGUCUCu 5'
             || |||:: | ||||||| 
Target 5' gggGTCAAGTTCTTCTCAGAGa 3'
 2460 - 2481 163.00 -19.60
2 
miRNA  3' ccacaAUUCGG--AACGAGUCUcu 5'
               ||||::  || ||||||  
Target 5' aggaaTAAGTTGGTT-CTCAGAag 3'
 2485 - 2507 134.00 -11.40
3 
miRNA  3' ccACAAUUCG-GAACGAGUCUcu 5'
            || |:| | :|||||:|||  
Target 5' tcTGCTGATCTTTTGCTTAGAcg 3'
 2546 - 2568 132.00 -10.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM7835433 9 COSMIC
COSM7094747 15 COSMIC
COSM8047985 18 COSMIC
COSM8724585 26 COSMIC
COSM7459215 27 COSMIC
COSM5550973 39 COSMIC
COSM8662085 52 COSMIC
COSM4418805 64 COSMIC
COSM7171273 81 COSMIC
COSN58545 82 COSMIC
COSN20520369 97 COSMIC
COSN508638 98 COSMIC
COSN30156288 107 COSMIC
COSN31511571 110 COSMIC
COSN30518821 121 COSMIC
COSN31611304 127 COSMIC
COSN30534287 131 COSMIC
COSN30700476 136 COSMIC
COSN30483417 141 COSMIC
COSN20051097 143 COSMIC
COSN30485448 148 COSMIC
COSN30535352 155 COSMIC
COSN30454089 173 COSMIC
COSN30461249 196 COSMIC
COSN28822451 214 COSMIC
COSN28729878 347 COSMIC
COSN20102729 626 COSMIC
COSN15269561 747 COSMIC
COSN23712970 1038 COSMIC
COSN9312236 1154 COSMIC
COSN7870844 1693 COSMIC
COSN20851149 1804 COSMIC
COSN7870843 2108 COSMIC
COSN19606443 2122 COSMIC
COSN397616 2142 COSMIC
COSN25589531 2421 COSMIC
rs9276975 1016 GWAS
rs3128935 2211 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs766949356 2 dbSNP
rs754149653 5 dbSNP
rs1388923310 7 dbSNP
rs764491094 7 dbSNP
rs1211904002 10 dbSNP
rs750727861 11 dbSNP
rs1268714790 14 dbSNP
rs1321366603 16 dbSNP
rs1208079669 23 dbSNP
rs767961845 33 dbSNP
rs761940357 35 dbSNP
rs1233453731 37 dbSNP
rs774696923 46 dbSNP
rs768881441 56 dbSNP
rs190487915 61 dbSNP
rs2582 64 dbSNP
rs111506959 65 dbSNP
rs1321775859 66 dbSNP
rs1457241736 67 dbSNP
rs1208252858 69 dbSNP
rs1383244191 70 dbSNP
rs770807497 71 dbSNP
rs531779625 76 dbSNP
rs777400152 77 dbSNP
rs1446077184 82 dbSNP
rs1263323798 83 dbSNP
rs1473819138 85 dbSNP
rs771959094 90 dbSNP
rs747908772 92 dbSNP
rs778640064 94 dbSNP
rs988578457 96 dbSNP
rs753347071 97 dbSNP
rs141874596 98 dbSNP
rs1280397189 102 dbSNP
rs185621047 112 dbSNP
rs751009245 119 dbSNP
rs763607952 120 dbSNP
rs1230213224 124 dbSNP
rs767763942 127 dbSNP
rs762182579 135 dbSNP
rs372446353 136 dbSNP
rs572016741 138 dbSNP
rs1028990923 154 dbSNP
rs981132505 159 dbSNP
rs970167216 165 dbSNP
rs1354945947 168 dbSNP
rs1329922505 172 dbSNP
rs996177740 173 dbSNP
rs1386589206 185 dbSNP
rs148263801 188 dbSNP
rs1195591060 190 dbSNP
rs541460099 197 dbSNP
rs1272858228 210 dbSNP
rs577145842 211 dbSNP
rs2581 214 dbSNP
rs113547757 215 dbSNP
rs888005875 216 dbSNP
rs537558088 217 dbSNP
rs1026498777 222 dbSNP
rs1184759806 232 dbSNP
rs1369903082 234 dbSNP
rs999720229 236 dbSNP
rs902706292 238 dbSNP
rs1472890807 246 dbSNP
rs993633483 250 dbSNP
rs1431372398 253 dbSNP
rs1308610662 261 dbSNP
rs1043972179 264 dbSNP
rs901933597 269 dbSNP
rs3129302 272 dbSNP
rs113990164 273 dbSNP
rs892765398 274 dbSNP
rs1226908620 289 dbSNP
rs781084947 290 dbSNP
rs1157578397 294 dbSNP
rs1055474423 296 dbSNP
rs1344802084 297 dbSNP
rs181875368 297 dbSNP
rs1043712039 304 dbSNP
rs1482558574 313 dbSNP
rs937042933 320 dbSNP
rs1365214316 321 dbSNP
rs928386699 323 dbSNP
rs372806804 325 dbSNP
rs940521626 328 dbSNP
rs566412045 346 dbSNP
rs408036 347 dbSNP
rs1451167150 354 dbSNP
rs1224616782 357 dbSNP
rs952060024 375 dbSNP
rs1168988916 380 dbSNP
rs1377006083 384 dbSNP
rs1464429197 385 dbSNP
rs1028917136 386 dbSNP
rs928467747 388 dbSNP
rs1490508913 389 dbSNP
rs1158842423 403 dbSNP
rs1285364199 411 dbSNP
rs974729473 414 dbSNP
rs1353058804 422 dbSNP
rs969815071 424 dbSNP
rs1229690817 435 dbSNP
rs1303046662 462 dbSNP
rs966078870 463 dbSNP
rs188923832 465 dbSNP
rs1236021405 470 dbSNP
rs1257069102 476 dbSNP
rs750495387 492 dbSNP
rs543687081 493 dbSNP
rs1022886844 512 dbSNP
rs1245889317 513 dbSNP
rs1465924873 519 dbSNP
rs1188991939 528 dbSNP
rs1026530053 531 dbSNP
rs417812 534 dbSNP
rs895410780 536 dbSNP
rs1178184656 539 dbSNP
rs1055442929 547 dbSNP
rs936972328 548 dbSNP
rs1456831814 565 dbSNP
rs906895119 575 dbSNP
rs183993098 584 dbSNP
rs1391111113 606 dbSNP
rs1436029913 607 dbSNP
rs143031101 610 dbSNP
rs907662923 611 dbSNP
rs1398473851 618 dbSNP
rs946683491 621 dbSNP
rs200491033 629 dbSNP
rs369631962 630 dbSNP
rs9280259 630 dbSNP
rs1158787810 639 dbSNP
rs985038069 644 dbSNP
rs1477529067 646 dbSNP
rs930533607 660 dbSNP
rs1264458807 664 dbSNP
rs1053004129 667 dbSNP
rs921872910 671 dbSNP
rs1375704126 681 dbSNP
rs1268054302 684 dbSNP
rs934571057 685 dbSNP
rs1180123460 688 dbSNP
rs752689137 689 dbSNP
rs974657598 690 dbSNP
rs966005726 702 dbSNP
rs149444481 705 dbSNP
rs1262419432 716 dbSNP
rs138005521 729 dbSNP
rs560422543 730 dbSNP
rs967203203 736 dbSNP
rs3129303 737 dbSNP
rs1011507769 739 dbSNP
rs574425652 744 dbSNP
rs577832783 746 dbSNP
rs1265351380 753 dbSNP
rs1224541935 754 dbSNP
rs1265748701 756 dbSNP
rs1003830148 758 dbSNP
rs906864062 761 dbSNP
rs1253858666 773 dbSNP
rs9276977 774 dbSNP
rs191517336 783 dbSNP
rs1181352304 788 dbSNP
rs1411908678 804 dbSNP
rs146954274 816 dbSNP
rs1004603165 817 dbSNP
rs9276976 821 dbSNP
rs1327673937 823 dbSNP
rs772650175 830 dbSNP
rs1428182694 832 dbSNP
rs1310434716 834 dbSNP
rs367671089 836 dbSNP
rs1442387718 851 dbSNP
rs1413530054 860 dbSNP
rs1283020814 866 dbSNP
rs142575366 867 dbSNP
rs3129304 872 dbSNP
rs1010942504 876 dbSNP
rs1038921803 882 dbSNP
rs1052373375 883 dbSNP
rs998746994 894 dbSNP
rs777179752 897 dbSNP
rs1422755766 898 dbSNP
rs1045984215 902 dbSNP
rs1484379428 904 dbSNP
rs948543400 908 dbSNP
rs1389754972 909 dbSNP
rs1476385579 911 dbSNP
rs1448108394 913 dbSNP
rs1170874722 914 dbSNP
rs186710498 916 dbSNP
rs1186985224 918 dbSNP
rs1332953968 923 dbSNP
rs1356973497 926 dbSNP
rs1048877590 927 dbSNP
rs1440868683 929 dbSNP
rs1364006628 941 dbSNP
rs371574753 945 dbSNP
rs978508900 947 dbSNP
rs1317688397 954 dbSNP
rs1256629628 955 dbSNP
rs1218536144 956 dbSNP
rs746427732 958 dbSNP
rs915291697 962 dbSNP
rs1204366878 966 dbSNP
rs1270237380 968 dbSNP
rs1247711077 982 dbSNP
rs1463657802 986 dbSNP
rs1190924082 992 dbSNP
rs989591641 1002 dbSNP
rs1243006825 1009 dbSNP
rs959518272 1011 dbSNP
rs9276975 1016 dbSNP
rs1003759495 1018 dbSNP
rs1171391271 1034 dbSNP
rs1427854438 1038 dbSNP
rs1338304974 1039 dbSNP
rs374180982 1043 dbSNP
rs1176434786 1048 dbSNP
rs912112010 1052 dbSNP
rs970976696 1057 dbSNP
rs1326851051 1061 dbSNP
rs1411563606 1065 dbSNP
rs758648827 1071 dbSNP
rs1162687316 1078 dbSNP
rs1022878804 1081 dbSNP
rs1442871551 1084 dbSNP
rs771203429 1084 dbSNP
rs1010975172 1087 dbSNP
rs410168 1102 dbSNP
rs376283826 1104 dbSNP
rs886131659 1105 dbSNP
rs1210778107 1106 dbSNP
rs1030973989 1109 dbSNP
rs147714266 1113 dbSNP
rs1235405360 1114 dbSNP
rs1481019076 1115 dbSNP
rs1199546193 1119 dbSNP
rs1410533510 1120 dbSNP
rs548644792 1129 dbSNP
rs1045687742 1130 dbSNP
rs900343305 1135 dbSNP
rs1404616621 1136 dbSNP
rs66591426 1139 dbSNP
rs70996750 1139 dbSNP
rs554957239 1147 dbSNP
rs184205711 1149 dbSNP
rs930400644 1150 dbSNP
rs1227186240 1153 dbSNP
rs1356642671 1160 dbSNP
rs897551506 1162 dbSNP
rs1280429392 1164 dbSNP
rs1316611001 1165 dbSNP
rs1036039258 1176 dbSNP
rs1292412187 1183 dbSNP
rs1490666562 1184 dbSNP
rs1205128383 1187 dbSNP
rs944350737 1192 dbSNP
rs911814963 1197 dbSNP
rs1183346058 1199 dbSNP
rs1296199934 1200 dbSNP
rs1472225095 1202 dbSNP
rs1161266154 1222 dbSNP
rs757410366 1226 dbSNP
rs1425026638 1228 dbSNP
rs1354977776 1229 dbSNP
rs1307408260 1232 dbSNP
rs945355738 1235 dbSNP
rs1411747486 1240 dbSNP
rs1322817074 1248 dbSNP
rs1422738867 1249 dbSNP
rs1367512103 1253 dbSNP
rs142850513 1263 dbSNP
rs751702185 1263 dbSNP
rs762940672 1263 dbSNP
rs1439281068 1269 dbSNP
rs1286147334 1308 dbSNP
rs915278264 1309 dbSNP
rs71565360 1312 dbSNP
rs1470721220 1314 dbSNP
rs551525651 1315 dbSNP
rs192648308 1316 dbSNP
rs989579492 1319 dbSNP
rs562791584 1320 dbSNP
rs1441517719 1322 dbSNP
rs1490998019 1329 dbSNP
rs1386683572 1334 dbSNP
rs416622 1334 dbSNP
rs1388263447 1335 dbSNP
rs1391285473 1337 dbSNP
rs532772507 1339 dbSNP
rs1352463768 1340 dbSNP
rs970981871 1347 dbSNP
rs1304429074 1348 dbSNP
rs3128936 1352 dbSNP
rs1373781282 1354 dbSNP
rs3097647 1355 dbSNP
rs950428371 1356 dbSNP
rs1367413938 1361 dbSNP
rs1303792121 1368 dbSNP
rs1027318476 1370 dbSNP
rs1343590012 1372 dbSNP
rs1343733652 1384 dbSNP
rs111651065 1386 dbSNP
rs894357229 1391 dbSNP
rs1461446263 1398 dbSNP
rs994509289 1406 dbSNP
rs1027504671 1417 dbSNP
rs994640969 1420 dbSNP
rs1430054731 1422 dbSNP
rs1401566574 1423 dbSNP
rs1193878187 1430 dbSNP
rs1376990023 1443 dbSNP
rs188921606 1448 dbSNP
rs1017365162 1449 dbSNP
rs1008665875 1454 dbSNP
rs1456863921 1460 dbSNP
rs1318997945 1463 dbSNP
rs890322305 1470 dbSNP
rs1481683344 1474 dbSNP
rs140621232 1477 dbSNP
rs945351861 1478 dbSNP
rs79804075 1480 dbSNP
rs1264411382 1483 dbSNP
rs1258506191 1486 dbSNP
rs1217479924 1490 dbSNP
rs1050496541 1496 dbSNP
rs539186111 1517 dbSNP
rs938048926 1518 dbSNP
rs1221492816 1519 dbSNP
rs926714524 1521 dbSNP
rs776040928 1525 dbSNP
rs982217212 1529 dbSNP
rs1283858563 1535 dbSNP
rs769162090 1542 dbSNP
rs578215383 1545 dbSNP
rs556433912 1550 dbSNP
rs989609278 1551 dbSNP
rs983438901 1553 dbSNP
rs537474779 1562 dbSNP
rs1027246449 1563 dbSNP
rs1358836631 1574 dbSNP
rs1293243606 1575 dbSNP
rs973058868 1576 dbSNP
rs964368774 1579 dbSNP
rs761112485 1580 dbSNP
rs1017293765 1590 dbSNP
rs1407254886 1591 dbSNP
rs1174670786 1592 dbSNP
rs1471167510 1601 dbSNP
rs1430522848 1604 dbSNP
rs1170587176 1621 dbSNP
rs764972354 1622 dbSNP
rs1227236281 1624 dbSNP
rs971199991 1625 dbSNP
rs566905035 1626 dbSNP
rs1243607650 1629 dbSNP
rs775870698 1630 dbSNP
rs1427318431 1631 dbSNP
rs1264584551 1634 dbSNP
rs772571462 1644 dbSNP
rs1224681221 1645 dbSNP
rs1269485543 1647 dbSNP
rs1482803272 1649 dbSNP
rs1180099870 1654 dbSNP
rs1410456511 1658 dbSNP
rs991202365 1667 dbSNP
rs1485965998 1669 dbSNP
rs1008680307 1684 dbSNP
rs746305112 1688 dbSNP
rs958659767 1689 dbSNP
rs890282156 1694 dbSNP
rs1020788504 1707 dbSNP
rs1009863682 1710 dbSNP
rs35776718 1712 dbSNP
rs771329933 1713 dbSNP
rs1295884524 1719 dbSNP
rs1375096823 1727 dbSNP
rs376892 1728 dbSNP
rs1263596097 1729 dbSNP
rs1311527522 1731 dbSNP
rs566514911 1733 dbSNP
rs1226580468 1734 dbSNP
rs1292494548 1737 dbSNP
rs937977079 1738 dbSNP
rs1008671964 1739 dbSNP
rs905223522 1748 dbSNP
rs1046511179 1749 dbSNP
rs1480983401 1749 dbSNP
rs1181552042 1751 dbSNP
rs949537258 1753 dbSNP
rs908666856 1758 dbSNP
rs1297763624 1764 dbSNP
rs982980894 1766 dbSNP
rs1390111287 1772 dbSNP
rs551296321 1778 dbSNP
rs893470216 1806 dbSNP
rs1355811548 1813 dbSNP
rs1442270008 1816 dbSNP
rs1053997967 1818 dbSNP
rs768051697 1819 dbSNP
rs975664225 1825 dbSNP
rs1046974100 1833 dbSNP
rs561848147 1834 dbSNP
rs751456162 1837 dbSNP
rs987585440 1849 dbSNP
rs1212778568 1859 dbSNP
rs954493866 1862 dbSNP
rs1331156447 1863 dbSNP
rs780104312 1866 dbSNP
rs1021177450 1868 dbSNP
rs533147437 1873 dbSNP
rs1460886669 1892 dbSNP
rs758172914 1898 dbSNP
rs957881705 1899 dbSNP
rs1032248614 1900 dbSNP
rs952730387 1902 dbSNP
rs919919455 1909 dbSNP
rs142274730 1918 dbSNP
rs592625 1925 dbSNP
rs184022096 1930 dbSNP
rs1046398336 1932 dbSNP
rs1420830178 1934 dbSNP
rs1014779276 1935 dbSNP
rs1174665212 1941 dbSNP
rs1384142637 1944 dbSNP
rs1014055699 1952 dbSNP
rs1009118036 1953 dbSNP
rs148716738 1959 dbSNP
rs761481415 1961 dbSNP
rs1364256777 1963 dbSNP
rs542998809 1970 dbSNP
rs1044429 1973 dbSNP
rs893501332 1976 dbSNP
rs1362493968 1978 dbSNP
rs1053365493 1986 dbSNP
rs1261279199 1990 dbSNP
rs1325960417 1995 dbSNP
rs560628805 1997 dbSNP
rs545321609 2001 dbSNP
rs1195041079 2006 dbSNP
rs1479589968 2013 dbSNP
rs1253022961 2018 dbSNP
rs1228161860 2019 dbSNP
rs920125779 2021 dbSNP
rs112447421 2035 dbSNP
rs578105717 2036 dbSNP
rs190834949 2044 dbSNP
rs999749081 2045 dbSNP
rs367892819 2056 dbSNP
rs1426645570 2058 dbSNP
rs1481120320 2068 dbSNP
rs569150517 2070 dbSNP
rs1248419238 2074 dbSNP
rs1383846434 2079 dbSNP
rs1306683454 2094 dbSNP
rs543748753 2099 dbSNP
rs1399187269 2100 dbSNP
rs1387450837 2103 dbSNP
rs1046569526 2104 dbSNP
rs942957125 2122 dbSNP
rs910184831 2123 dbSNP
rs1161180267 2128 dbSNP
rs573965600 2129 dbSNP
rs554944672 2140 dbSNP
rs1224183798 2142 dbSNP
rs1288034441 2144 dbSNP
rs1348725260 2151 dbSNP
rs1225845414 2167 dbSNP
rs1285332483 2170 dbSNP
rs919948714 2178 dbSNP
rs1230047201 2182 dbSNP
rs1271668368 2186 dbSNP
rs763529731 2192 dbSNP
rs1490717258 2195 dbSNP
rs988326392 2197 dbSNP
rs1468244064 2198 dbSNP
rs111664781 2200 dbSNP
rs1408487418 2202 dbSNP
rs1301278015 2203 dbSNP
rs961968835 2203 dbSNP
rs1367362230 2210 dbSNP
rs3128935 2211 dbSNP
rs1002083573 2213 dbSNP
rs554894951 2214 dbSNP
rs539291234 2228 dbSNP
rs1013567544 2229 dbSNP
rs1334223803 2240 dbSNP
rs1241495831 2242 dbSNP
rs954735909 2248 dbSNP
rs759959757 2250 dbSNP
rs995904165 2255 dbSNP
rs1289643095 2257 dbSNP
rs1294595726 2258 dbSNP
rs957758880 2262 dbSNP
rs1031979025 2264 dbSNP
rs1249168216 2265 dbSNP
rs774896442 2266 dbSNP
rs1183594128 2267 dbSNP
rs995587032 2278 dbSNP
rs999110286 2283 dbSNP
rs898628278 2286 dbSNP
rs1039855795 2293 dbSNP
rs1013831573 2310 dbSNP
rs1237248173 2312 dbSNP
rs1167440822 2318 dbSNP
rs895334614 2320 dbSNP
rs942926486 2336 dbSNP
rs1308226272 2337 dbSNP
rs369937275 2356 dbSNP
rs912831887 2357 dbSNP
rs1051806627 2358 dbSNP
rs536685229 2359 dbSNP
rs1450934065 2390 dbSNP
rs931405107 2392 dbSNP
rs11538885 2401 dbSNP
rs182722479 2402 dbSNP
rs898553684 2404 dbSNP
rs1300690301 2406 dbSNP
rs3130602 2408 dbSNP
rs940042361 2411 dbSNP
rs1336945934 2412 dbSNP
rs1390923168 2422 dbSNP
rs987907636 2425 dbSNP
rs1197028110 2429 dbSNP
rs1273273365 2430 dbSNP
rs1460555698 2443 dbSNP
rs866117502 2448 dbSNP
rs1181546987 2449 dbSNP
rs769890355 2451 dbSNP
rs3128933 2452 dbSNP
rs17214148 2453 dbSNP
rs980616015 2455 dbSNP
rs190122176 2457 dbSNP
rs754770831 2458 dbSNP
rs1463595957 2461 dbSNP
rs1385295517 2462 dbSNP
rs1168512947 2464 dbSNP
rs549153086 2490 dbSNP
rs1338914232 2500 dbSNP
rs1384049820 2503 dbSNP
rs1434804056 2509 dbSNP
rs144268384 2511 dbSNP
rs748317002 2521 dbSNP
rs1328641989 2522 dbSNP
rs367971885 2529 dbSNP
rs527679850 2532 dbSNP
rs1266707574 2533 dbSNP
rs1201608802 2540 dbSNP
rs992517241 2545 dbSNP
rs951408987 2557 dbSNP
rs376054731 2567 dbSNP
rs1032010210 2568 dbSNP
rs1322436937 2580 dbSNP
rs995515082 2589 dbSNP
rs1283727215 2633 dbSNP
rs1203595372 2638 dbSNP
rs1264601829 2639 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ccacAAUUCGGAACGAGUCUcu 5'
              | |||:: | ||||||  
Target 5' ----UCAAGUUCUUCUCAGA-- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000229829.5 | 3UTR | UCAAGUUCUUCUCAGAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000229829.5 | 3UTR | UCAAGUUCUUCUCAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
78 hsa-miR-4653-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT118186 ZNF544 zinc finger protein 544 2 2
MIRT332935 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT442166 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442387 CLVS2 clavesin 2 2 2
MIRT442595 SIX1 SIX homeobox 1 2 2
MIRT448014 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448061 MMP15 matrix metallopeptidase 15 2 2
MIRT489017 C1QTNF6 C1q and TNF related 6 2 2
MIRT494456 BTG2 BTG anti-proliferation factor 2 2 2
MIRT495650 SLC35B2 solute carrier family 35 member B2 2 2
MIRT504016 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT506777 KLHL15 kelch like family member 15 2 4
MIRT507229 FOXN2 forkhead box N2 2 4
MIRT512550 MFN2 mitofusin 2 2 6
MIRT512842 A1CF APOBEC1 complementation factor 2 6
MIRT513944 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT516103 GADL1 glutamate decarboxylase like 1 2 4
MIRT519831 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT523210 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT525008 ACTN4 actinin alpha 4 2 6
MIRT528858 PKP1 plakophilin 1 2 2
MIRT529062 ZNF675 zinc finger protein 675 2 2
MIRT531719 TARS threonyl-tRNA synthetase 2 2
MIRT534039 STK4 serine/threonine kinase 4 2 2
MIRT543848 APIP APAF1 interacting protein 2 2
MIRT545866 ZNF264 zinc finger protein 264 2 4
MIRT556037 MXD1 MAX dimerization protein 1 2 2
MIRT557081 HOXB3 homeobox B3 2 2
MIRT561345 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT562705 ZNF415 zinc finger protein 415 2 2
MIRT563223 ZNF286A zinc finger protein 286A 2 2
MIRT563860 ZNF616 zinc finger protein 616 2 4
MIRT563879 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT564652 ZNF487P zinc finger protein 487 1 1
MIRT566595 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT570878 ZFP1 ZFP1 zinc finger protein 2 2
MIRT573067 TRIB1 tribbles pseudokinase 1 2 2
MIRT573941 ZNF708 zinc finger protein 708 2 2
MIRT575966 Slfn5 schlafen 5 2 5
MIRT607293 CD300E CD300e molecule 2 4
MIRT608187 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT609537 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT610152 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611571 SLFN5 schlafen family member 5 2 7
MIRT613335 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT616560 ZNF512B zinc finger protein 512B 2 2
MIRT617240 SPATS2 spermatogenesis associated serine rich 2 2 2
MIRT618011 SLC9A3R2 SLC9A3 regulator 2 2 2
MIRT618478 IL17REL interleukin 17 receptor E like 2 2
MIRT619099 IFI44L interferon induced protein 44 like 2 2
MIRT622265 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT623080 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT625621 LILRB2 leukocyte immunoglobulin like receptor B2 2 2
MIRT627844 PLEKHA6 pleckstrin homology domain containing A6 2 2
MIRT630459 GMPS guanine monophosphate synthase 2 2
MIRT630524 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 4
MIRT631502 TAF8 TATA-box binding protein associated factor 8 2 2
MIRT634537 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638807 DCTN3 dynactin subunit 3 2 2
MIRT641303 SLAMF1 signaling lymphocytic activation molecule family member 1 2 2
MIRT648347 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT649705 ZNF175 zinc finger protein 175 2 2
MIRT652554 TLX1 T-cell leukemia homeobox 1 2 2
MIRT655564 P2RX7 purinergic receptor P2X 7 2 2
MIRT659065 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT660341 BCAT1 branched chain amino acid transaminase 1 2 2
MIRT664330 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT688934 ATXN7L3B ataxin 7 like 3B 2 2
MIRT689971 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT699514 SKIL SKI like proto-oncogene 2 2
MIRT699975 RREB1 ras responsive element binding protein 1 2 2
MIRT702676 IRS2 insulin receptor substrate 2 2 2
MIRT709357 ULK2 unc-51 like autophagy activating kinase 2 2 2
MIRT709837 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT718716 ANKRD18A ankyrin repeat domain 18A 2 2
MIRT718879 PDIA3 protein disulfide isomerase family A member 3 2 2
MIRT724105 TMEM199 transmembrane protein 199 2 2
MIRT724763 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Paclitaxel 36314 NSC125973 approved sensitive High Nasopharyngeal Cancer cell line (CNE-1)
hsa-mir-4653 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4653-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)

Error report submission