miRTarBase - #MIRT448704


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pre-miRNA Information
pre-miRNA hsa-mir-3915   
Genomic Coordinates chrX: 32583656 - 32583752
Description Homo sapiens miR-3915 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3915
Sequence 21| UUGAGGAAAAGAUGGUCUUAUU |42
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs997323565 10 dbSNP
rs1192161547 15 dbSNP
rs1255075246 19 dbSNP
rs1452812574 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KLHL11   
Synonyms -
Description kelch like family member 11
Transcript NM_018143   
Expression
Putative miRNA Targets on KLHL11
3'UTR of KLHL11
(miRNA target sites are highlighted)		 
>KLHL11|NM_018143|3'UTR
   1 GTTCTCTCAAGCGTGCCGATTAAAACTGTTACACCCGTTTCGTGAAGCTGAAGATACCCAGGCTGTTATTTAAAAAAGTA
  81 TGTCGATAACTTATTTTCTACATGAACTGATTATTACCCCATATAAAGGAAATAGAGTTAAAAACTAAAGAATGGGAGAC
 161 TCAGTTCAATACATGGTCATTTTGTTAGCTTGCAATTTTTGTCTTTGGTTTGTTTGTTTGTGCTAGCTAAATAAGATCTT
 241 ATTAAGGACAAGTGGAAAAATCAGGTGTAGTTGCTTAGCTGTTTTCCTGCCAACGAGTTATGACTCCTTTGTCTTGAGGA
 321 CTTACGTTTTGAACATGCTTTAAGCACCAATTTTATTTGCACATTTACTTTGATATTCTTTTTCATTTTTTATTAAATGA
 401 TTGGTTTTGGCAAGATCTGACTTCTGCATTGAGCCCTCATCTGCAGGAGGCATGTGCAATAGTGAGACTGAAATTTGAAT
 481 GAAAACACTCAATATTTCAGCAAGATAATTTGAGAATGTTTGCATTGATATTTTCTTATGTTTATCTAGAAATGCCAGTT
 561 TCCTTCCTAGAAGATGTGACTGATGAGAAATTTTTTACTGGCTCATGCATTTTTTGAATATTTTTCATTAGCAGCTGTTT
 641 ATAGACTTTAAGCCTTCAATCTGAGGTGACGGTAGTTGGCAAAAGTATAGATCTTTAGCTAATTGACTAAATACAGAGCA
 721 AGTTACATGTGTGAACTTTGTTTCTCTAAGAAGAAAAGTATTAGTGTAGACTGGGAAATCAAAGGCATTTAAAATTTTTT
 801 CAACATTTTTTTCAGGAGTTGCAGGATTATTTGAGGATATGTTAATGAGTGTAAATAATGCCTATGACAATCGACACTCA
 881 ATGCCTTCCATTTTAATTTTTGCTCTAATGCATATTATATAGAATCTTCATTATTCCTTTTCTCTTTTTTTTTTTTTTTT
 961 TGCTCATGTTGCCCAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGCCTGCCAGGTTCGAGTGATTCT
1041 CTTGCCTCAGCATCCCGAGTAGCTGGGATTACAGGTACCCACCATCACGCCTGGCTAATTTTTGTGCTTTTAGTAGAGAC
1121 AGGGTTTCACCATGTTGACCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATACGCCCGCCTCAGCCTCCCAAAGTGCTG
1201 GGATTACAGGCATGAGCCACCGTGCCCAGTCCATTATTCTTTTCTACAAGAAACTGTTTTTTTCCAAAATGGGAAGGAAG
1281 TCACAATTTAGAGAAATGTTGCTAAAGAGAAGCCTTATTATTTCTGATTGTTATATTTTATCCAGTTGCCCCACACTTTC
1361 AAACTTTGCCTGAGCCTAGGATACCAAATTTGGGTACATAATTTTGGCTTTTAAAGGTTTATGGGCTGGGCACGGTGGCT
1441 CATGACTGTAATCCCAACACTTTGGAGGAGGCTGAGGTGGGCAGATTTTGAGCCCAAGAGTTCAAGACCAGCCTGGGAAA
1521 CATAGCAAGATCCTGTCTCTACAAAAAGTAGAAAAATTAGCTGAGTGTGGTAGCTGGCACGTGCCTGTAGTCCTTCCTAC
1601 TTGAAGCCAAGGTGGGAGGATCACCAGAGCCTGGGAAGGTTGAGGCTGAAATGAGCTGTGATCATGCCACTCTACCTTGG
1681 GTGACAGAGAGACGGTGTCTCAAATAAAAATTAAAAAGATCACTGAAGCTATCTTTTATTTAGTTTTATACGTTATTCGA
1761 ATTATCTTATGTCTCCTGAGCTTTATAAAAGTTAGCACTCAAATTGACTTTTTTTTTTTTTTGGGCCAGGGGATGGGGTC
1841 CCACTTTGTCACCCAGGTTGGAGTACAGTGGTATGATCTCGGCTCACTACAACCTCCACCTCCTGGATGCAAGCCATCCT
1921 GCCACCTCAGCATACGGAGTAGCTGGGACTATGGGCACGCGCCACCACGCCCAGCTAATTTTTTTTTTGTATTTTTGGTA
2001 GAGATGGGGTTTCTCCATGTTGCCGAGGCTGGTCTCCAACTCCTGGGCTCAGGAGATCCACCCGTATCAGCCTCCCAGGG
2081 TGCTAGGATTAGGTGTGAGCCACCACGCCCGGCCTCAAAATAACTTTTTTTTTTTTTTTTGAAACAGTCACGCTTTGTCG
2161 CCCTGGCTGGAGTGCAGTTGCGCAGTCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCATGTGATTCTCCTGCCTCAGC
2241 CTGCTGAGTAGCTGGGATTGCAGGTGTGTACCACCACGCCCGGCTAATTTTTGTATTTTTAATAGAGATGGGGTTTCACC
2321 ATGTTGGTTAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGCCCACCTCAGCCTCTCAAAGCGCTGGGATTACAGGCAT
2401 GAGCCACCATGCCCAGCCCTCAAATTTACTCTTAATGCTCAGTTAATATAAAGGATTCCTAACAGTTTACAATGTGGTTT
2481 TCTTGTTTTTGTTGTTGTTTTGGTTTTTTAAGATGTGAGGTCTCACCTTATTGGCCAGGCTGGTCTCAAGCTCCTTTCCT
2561 CAAGCAATCCTCCCACCTTGGCCTCCCAAAGAGCCACCTGTCCAATGATTTATCCTGTTTCTTAAGAACTGTCTTTACCT
2641 TCTTAGACATTTTGTCATACCATTCTAGAAGTCAAATTCCAAGTGCAGTGATTTTTTTTTTCCCTAGTCCATTATAGTTA
2721 ATCTTCTTGTTAGTGATCAAATACCAAAAGAGAAAAGCACAACCAGAAATTTTGGCTATTTGCTGCAAGTTGTAGGTCTT
2801 GGGCTCTATACTAAGAACTTGAAATTTTTAAATTAGTATCCCTGCCTAGGTGAAAAGTTTTTAATAAATGTGTTGAAAAT
2881 CAACTTTAAATCCATTTAATTTAGACTGGAGTGGGCGTGAGAAACTGCAAGTCTATTTCTACATATAAGGATATATTATT
2961 ATATTGTCCCATCCCACCACTACCTTTTTCTCAATTTCTATTTCTTTGTAGTTATTTTAGTAAAAGCCATTTGGATTCTG
3041 AGAAGCACTAATTCTTAGCTGTGATAGGTCTATGCAAGTAAGACAGAATCATTAAATGAAGCTCACTAAATGAAGTTCTC
3121 ATTTCTCTCCAACAGACTGTGCTAGCAAACTTCGTTTTCTTGATTGTATTTAAATAATTTAGTATCTCACTACGATAATA
3201 GTTTTTAACTGGAAGGGTGTGATGTGTTTTTTGTTTTTTGTTCTCAGAGTTGTCTTCTGAGATAATTATTACCAAGTCAT
3281 TTGTGGGGTTGTGTTTTTTTCACATCATGTGACAGAAATTATAACTCATAAGATTTAGGCATAATCTGGTTTTAAAACCT
3361 TGATTGAAACTGTTGTTTTTTAACTTAGCAGGCAGCCTAGGCCATGGCTGAAAAGAAGGGGTAAGTCCTTCATTGCATGA
3441 TGATGTGTGCAGGTTTTCCTGATTTTCTAATTTTTATTTTTGAATTCACATGTGTAATTTCACATCAATAACTTGTGTTT
3521 CTGAAATATCCTAACTAACTTGTTAATAAGGAAAGAAACCAGATTTGCTTAAATCTGTTCAAGGCTGACATTCTGAAATT
3601 CTAAACTGGAAATAACTTCCCAGAGTATTTGGAAAGGTTCTAAGTACAAGGATCAGGCCTAAAATAGCTCCTTGGGAAAG
3681 AAATTTCCTTTTTGATGAGAAAACTTAAAATATTGTTTTTGGTAATGTAAGCAGTTAAAAACATGACTTTAGAAAGACAG
3761 CTTAATGCGTATTCAAGCAAACCTTTGTTTTGTTGCTTTTGCTTTTGTTTGTAGAAGAGAGAGGAAGTTATTATACCAAA
3841 AAGTAATAGTATATGTAACTTTGAGTGAGGCTACTTATATCTTAGAATGGGTATCCTTGAACTATATCTACCCCACCATG
3921 GCTTAAAAAAATCAGTGGTATATATTGAGAATGTCAGTCATGAGCTTAGTGTTTAAGTAACACATCCCACTTACAGTTGT
4001 TTGCATGATTAGTCTTGTGTATCATGATGTTCAACTTTGCTTTTGCTGTGCCAGTTCAAAAATATCTTTTTTGCTAAAAA
4081 CTCTTAAAATTCATGACATAAGTTTTGTTTTGATCACCCGGTTTTATATAGTATTTCTGGGACCAAAAAATTTAAATATA
4161 CCTTTTTAATATAAAACAGAAGTTTGAAGCTGGAAAGATAGTGTTTATGGAAGATTTGTGTGCTTTTGTGTTTTTTAAAC
4241 CCGTCAGGCTGCTGGTAAGGCAGTTTCTAGGGCTCACTTTTCCTCCTTACCTCTTGACTAGTGTAGCATGTGGTATGTTT
4321 AAAATATTTCATTTTCTGCTTTGTAATTCTAAAGTCAACACTATACTGTATGTAGACAGGAGAGCTGATTTGTATATTTT
4401 AGTTATTTGGTCTAATCAAGCATAACTAAAGGGACTTCTTTTTTGATACTTTTCTCAAATTAAGTTTAAATATAGTATAC
4481 GGGCCACATTTCATGTCTTTGAAAGTGTTGTACATTACTGTAAACCAAGTACTCTGTCTACACCAGAGGGTGCTTTAACT
4561 GCAAAATATTTGAGAAACAATTCAGTCTCTCAAACATTTTGGCACAGTTCATCACTCCAGTTTGTTACTTTCTTGAGAAT
4641 AGTCCATTTTTTGTTTTTGTTATTGTACCGTATGTTCTGGTCATTGGAAACAGAACAGCTCATAGTTGGGTGATGTAATA
4721 TAATAACAGTAATATAACCTAGTAGTCATTTTGCTTCAAGTAATTTAATTAGATAGCAAAATCACTGCGGTTTGTTTATT
4801 ACACTTGTAGGGCTTTTTATCTTACTCAGTGACCATCACTACGAATGTCTTACATTGAAGCACAGACTGCAGAGCACTTG
4881 TTAACTTAGTCCTCCTGCATAATGCACTCGTGAAAAGTAGTGCTTGCTAGGTGTTTGAAGATTTTATGATCCGTGTGCTT
4961 GGGCTCGTTGAGTTATTTGTAAAATAAACATTTAGTTTGAGTTGATGCAGTAAGTTTTTTGGACTAGTAGTATCCAGGTC
5041 CCTACTCTACTGAAAATATAATCTTCACTATCTCCCCTTAACTCAGAGGAGATGTAGCATTTAGAACACCTTGAGACATG
5121 ACATTGTAAAATAGCTTGTTTTATGTTCCTGAAGCTATCTTGTTCTCTGTTAAAGCTACTAATTGTCTCAGTGTAAGTTT
5201 TAAATAAACATATTTCTTTAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuaUUCUGGUAGAAAAGGAGUu 5'
             |||  | || |||||||| 
Target 5' ctcAAG--C-TCCTTTCCTCAa 3'
 2545 - 2563 154.00 -10.90
2 
miRNA  3' uuAUUCUGGUAGAAAAGGAGuu 5'
            ||:|:|:  |||||||||  
Target 5' tcTAGGGCTCACTTTTCCTCct 3'
 4266 - 4287 152.00 -16.60
3 
miRNA  3' uuauucUGGUAGAAAAGGAGUu 5'
                ||:| |||||:|||| 
Target 5' cccaccACTACCTTTTTCTCAa 3'
 2973 - 2994 152.00 -14.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26981678 12 COSMIC
COSN14448442 18 COSMIC
COSN28196079 18 COSMIC
COSN31605924 21 COSMIC
COSN30484117 41 COSMIC
COSN15323960 42 COSMIC
COSN30150648 50 COSMIC
COSN30163464 58 COSMIC
COSN30104266 61 COSMIC
COSN31600883 72 COSMIC
COSN26981677 77 COSMIC
COSN31586780 81 COSMIC
COSN30130184 84 COSMIC
COSN30474486 109 COSMIC
COSN28213841 173 COSMIC
rs11079018 4342 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1022561115 1 dbSNP
rs781809728 4 dbSNP
rs782143717 7 dbSNP
rs782658735 9 dbSNP
rs141272202 13 dbSNP
rs782701158 16 dbSNP
rs782167307 18 dbSNP
rs372525901 23 dbSNP
rs1308247225 26 dbSNP
rs1319094980 26 dbSNP
rs782178567 32 dbSNP
rs782441570 32 dbSNP
rs782529514 33 dbSNP
rs781853437 36 dbSNP
rs17498875 37 dbSNP
rs782117531 39 dbSNP
rs782684163 41 dbSNP
rs79313880 42 dbSNP
rs781877614 47 dbSNP
rs1457043779 52 dbSNP
rs1178859577 57 dbSNP
rs941398226 58 dbSNP
rs1421809594 69 dbSNP
rs889893562 72 dbSNP
rs34262423 78 dbSNP
rs1164046960 82 dbSNP
rs782337623 87 dbSNP
rs556843474 101 dbSNP
rs1328011155 102 dbSNP
rs782481584 113 dbSNP
rs922666870 113 dbSNP
rs781840609 116 dbSNP
rs1298941036 121 dbSNP
rs1376040133 123 dbSNP
rs1227000588 129 dbSNP
rs1312389428 130 dbSNP
rs1336122403 132 dbSNP
rs1235606936 136 dbSNP
rs1255676640 164 dbSNP
rs1316731641 170 dbSNP
rs782189986 171 dbSNP
rs781915829 174 dbSNP
rs782414683 176 dbSNP
rs1234225660 178 dbSNP
rs1482043446 184 dbSNP
rs1181081897 195 dbSNP
rs1256514577 202 dbSNP
rs989094310 207 dbSNP
rs1168434416 208 dbSNP
rs934602920 211 dbSNP
rs879983855 216 dbSNP
rs1421641910 222 dbSNP
rs925747067 231 dbSNP
rs1465144182 238 dbSNP
rs978582095 242 dbSNP
rs969886024 244 dbSNP
rs1356511025 245 dbSNP
rs782274078 250 dbSNP
rs992568573 254 dbSNP
rs782638057 260 dbSNP
rs1302636292 263 dbSNP
rs1356498943 265 dbSNP
rs1417225284 267 dbSNP
rs1276831534 276 dbSNP
rs1316798288 291 dbSNP
rs1274429045 293 dbSNP
rs550348219 294 dbSNP
rs1208984770 297 dbSNP
rs1280856098 300 dbSNP
rs1486518690 301 dbSNP
rs6503672 302 dbSNP
rs1187195521 305 dbSNP
rs1262429192 305 dbSNP
rs1475675057 305 dbSNP
rs1025985344 307 dbSNP
rs1421655108 321 dbSNP
rs782211586 325 dbSNP
rs1376492633 326 dbSNP
rs1436935557 333 dbSNP
rs1296693968 335 dbSNP
rs1340465120 340 dbSNP
rs961665623 346 dbSNP
rs1271499427 348 dbSNP
rs568215810 360 dbSNP
rs1364861766 367 dbSNP
rs546962370 369 dbSNP
rs1303655067 372 dbSNP
rs1005705848 376 dbSNP
rs1349554790 385 dbSNP
rs1214213418 392 dbSNP
rs782588517 394 dbSNP
rs1284968127 398 dbSNP
rs1447513948 404 dbSNP
rs1217854151 409 dbSNP
rs1243972272 415 dbSNP
rs889988429 422 dbSNP
rs527674478 424 dbSNP
rs1193287971 432 dbSNP
rs998273365 435 dbSNP
rs1395954820 456 dbSNP
rs1455708820 459 dbSNP
rs1157235348 462 dbSNP
rs1384693766 482 dbSNP
rs564790410 486 dbSNP
rs1401853923 488 dbSNP
rs1320820981 492 dbSNP
rs901134666 506 dbSNP
rs1053137684 519 dbSNP
rs1303432618 525 dbSNP
rs1372737221 527 dbSNP
rs1237426986 539 dbSNP
rs934548024 554 dbSNP
rs925872677 555 dbSNP
rs1225444465 557 dbSNP
rs1287607129 559 dbSNP
rs1450923617 564 dbSNP
rs1213170196 574 dbSNP
rs1253640967 575 dbSNP
rs551772872 577 dbSNP
rs187677114 581 dbSNP
rs1176986866 588 dbSNP
rs566903851 590 dbSNP
rs1470697623 601 dbSNP
rs948546439 605 dbSNP
rs551880559 607 dbSNP
rs1412287259 616 dbSNP
rs1461322757 616 dbSNP
rs1326008069 621 dbSNP
rs183928800 626 dbSNP
rs1444203842 633 dbSNP
rs915781793 637 dbSNP
rs992500025 647 dbSNP
rs1444153335 649 dbSNP
rs563138189 670 dbSNP
rs959827618 671 dbSNP
rs146548969 674 dbSNP
rs760928240 687 dbSNP
rs1233818877 688 dbSNP
rs1273953537 697 dbSNP
rs544435143 701 dbSNP
rs1337010543 709 dbSNP
rs918890952 716 dbSNP
rs1197027441 728 dbSNP
rs971775226 747 dbSNP
rs1438558686 748 dbSNP
rs782801526 764 dbSNP
rs1184440115 770 dbSNP
rs1017185765 790 dbSNP
rs1005841055 791 dbSNP
rs1475208203 796 dbSNP
rs529540418 805 dbSNP
rs954154224 812 dbSNP
rs1166273454 825 dbSNP
rs1419455019 836 dbSNP
rs1463580441 843 dbSNP
rs1166769233 861 dbSNP
rs1396797003 864 dbSNP
rs1028503065 870 dbSNP
rs998240793 873 dbSNP
rs901274803 874 dbSNP
rs1415373857 881 dbSNP
rs1295016920 887 dbSNP
rs1053634828 889 dbSNP
rs1338281815 914 dbSNP
rs1216896193 929 dbSNP
rs998852093 939 dbSNP
rs1340325104 944 dbSNP
rs904553910 946 dbSNP
rs1277026165 947 dbSNP
rs1485538447 961 dbSNP
rs1189323899 962 dbSNP
rs1373086125 962 dbSNP
rs1463253973 962 dbSNP
rs528439576 971 dbSNP
rs1374667555 976 dbSNP
rs192086570 979 dbSNP
rs948643742 988 dbSNP
rs540560651 993 dbSNP
rs372936738 996 dbSNP
rs938409055 1000 dbSNP
rs1327092857 1001 dbSNP
rs1229956324 1010 dbSNP
rs1273271946 1012 dbSNP
rs1347381611 1018 dbSNP
rs918996447 1025 dbSNP
rs559685796 1027 dbSNP
rs572484363 1031 dbSNP
rs1205055908 1053 dbSNP
rs1261879918 1056 dbSNP
rs1429742351 1057 dbSNP
rs963068664 1072 dbSNP
rs908918170 1077 dbSNP
rs186008885 1085 dbSNP
rs183198604 1086 dbSNP
rs1175283233 1087 dbSNP
rs1028470373 1088 dbSNP
rs1289356919 1089 dbSNP
rs976927706 1089 dbSNP
rs575207860 1092 dbSNP
rs1031746713 1094 dbSNP
rs1235213401 1103 dbSNP
rs557020786 1104 dbSNP
rs1306177362 1107 dbSNP
rs999381480 1110 dbSNP
rs1315481300 1113 dbSNP
rs1239008787 1114 dbSNP
rs1261856449 1121 dbSNP
rs190213014 1123 dbSNP
rs1487107768 1124 dbSNP
rs904481567 1128 dbSNP
rs1251759935 1129 dbSNP
rs1468691927 1132 dbSNP
rs1195095275 1133 dbSNP
rs5004986 1138 dbSNP
rs1021590456 1151 dbSNP
rs1159516781 1155 dbSNP
rs1365491260 1156 dbSNP
rs55861010 1161 dbSNP
rs55784751 1162 dbSNP
rs1012759832 1170 dbSNP
rs1162885640 1171 dbSNP
rs12945295 1174 dbSNP
rs1393823381 1174 dbSNP
rs1057002534 1175 dbSNP
rs938516766 1178 dbSNP
rs55999651 1179 dbSNP
rs1308076879 1195 dbSNP
rs55775937 1198 dbSNP
rs1319254541 1203 dbSNP
rs1231989850 1206 dbSNP
rs897687866 1222 dbSNP
rs1215224813 1226 dbSNP
rs1230854604 1227 dbSNP
rs1480081039 1233 dbSNP
rs541735675 1242 dbSNP
rs1252326578 1245 dbSNP
rs879959098 1247 dbSNP
rs1417296186 1251 dbSNP
rs1462060491 1253 dbSNP
rs1036110407 1256 dbSNP
rs1352990162 1258 dbSNP
rs1461608753 1263 dbSNP
rs1299165220 1264 dbSNP
rs941782611 1272 dbSNP
rs1413520811 1281 dbSNP
rs908849627 1285 dbSNP
rs1356621132 1291 dbSNP
rs1234622215 1304 dbSNP
rs767874876 1312 dbSNP
rs985810834 1329 dbSNP
rs1204775258 1334 dbSNP
rs1252914639 1340 dbSNP
rs931658710 1343 dbSNP
rs1186907980 1347 dbSNP
rs377221118 1348 dbSNP
rs1476112596 1349 dbSNP
rs1417453818 1354 dbSNP
rs114478495 1360 dbSNP
rs977441227 1362 dbSNP
rs534942318 1364 dbSNP
rs1356688801 1380 dbSNP
rs1433286308 1392 dbSNP
rs1312605018 1394 dbSNP
rs1032257550 1396 dbSNP
rs977502107 1432 dbSNP
rs570778006 1433 dbSNP
rs1021559300 1434 dbSNP
rs1214847544 1440 dbSNP
rs781860623 1448 dbSNP
rs551761654 1449 dbSNP
rs1012854021 1453 dbSNP
rs1345233088 1456 dbSNP
rs111618590 1457 dbSNP
rs1280693656 1459 dbSNP
rs372011743 1463 dbSNP
rs1213539570 1464 dbSNP
rs1240477688 1470 dbSNP
rs1485564941 1481 dbSNP
rs574178445 1484 dbSNP
rs782076845 1494 dbSNP
rs563915253 1495 dbSNP
rs1173414269 1500 dbSNP
rs1396065849 1510 dbSNP
rs1036617578 1523 dbSNP
rs1316820859 1525 dbSNP
rs941765570 1537 dbSNP
rs1344133030 1541 dbSNP
rs887506018 1554 dbSNP
rs1430851369 1560 dbSNP
rs769572037 1580 dbSNP
rs931626136 1581 dbSNP
rs922969152 1599 dbSNP
rs1233103270 1603 dbSNP
rs1303950734 1607 dbSNP
rs976989623 1609 dbSNP
rs1222041893 1618 dbSNP
rs944292461 1623 dbSNP
rs1447463647 1625 dbSNP
rs1216612041 1630 dbSNP
rs1249908240 1631 dbSNP
rs1467362441 1633 dbSNP
rs1193231491 1637 dbSNP
rs1254076715 1638 dbSNP
rs1479192160 1644 dbSNP
rs924776934 1655 dbSNP
rs1401728601 1670 dbSNP
rs1160828251 1672 dbSNP
rs1391631134 1690 dbSNP
rs1439764324 1691 dbSNP
rs1326126059 1693 dbSNP
rs529451184 1693 dbSNP
rs761622110 1694 dbSNP
rs1278679654 1704 dbSNP
rs1351321151 1709 dbSNP
rs782163882 1723 dbSNP
rs7216461 1725 dbSNP
rs1270159548 1751 dbSNP
rs914647972 1752 dbSNP
rs148927710 1758 dbSNP
rs1453482854 1759 dbSNP
rs528725723 1761 dbSNP
rs1180112006 1764 dbSNP
rs1232659477 1765 dbSNP
rs1470831539 1769 dbSNP
rs958696446 1792 dbSNP
rs1415070351 1795 dbSNP
rs1460491397 1798 dbSNP
rs578251412 1801 dbSNP
rs1164949792 1802 dbSNP
rs1392450038 1809 dbSNP
rs1002764446 1812 dbSNP
rs1407794361 1815 dbSNP
rs1328015770 1817 dbSNP
rs962287798 1820 dbSNP
rs1336115001 1821 dbSNP
rs564449861 1822 dbSNP
rs1232765681 1823 dbSNP
rs1273815703 1823 dbSNP
rs1291330431 1823 dbSNP
rs199666907 1823 dbSNP
rs1358820168 1824 dbSNP
rs1194283768 1825 dbSNP
rs1272799653 1828 dbSNP
rs545435170 1829 dbSNP
rs575240847 1831 dbSNP
rs1256045624 1842 dbSNP
rs1475135895 1844 dbSNP
rs1188055322 1847 dbSNP
rs1014865626 1849 dbSNP
rs1369697001 1849 dbSNP
rs1474258008 1856 dbSNP
rs1166937441 1876 dbSNP
rs1396997130 1880 dbSNP
rs1006044387 1885 dbSNP
rs1310798132 1894 dbSNP
rs1374776394 1899 dbSNP
rs1415316625 1916 dbSNP
rs887641844 1925 dbSNP
rs7216097 1936 dbSNP
rs1225567022 1937 dbSNP
rs1269858856 1942 dbSNP
rs1231096543 1947 dbSNP
rs1278552467 1950 dbSNP
rs1485671771 1957 dbSNP
rs1212213159 1958 dbSNP
rs995926586 1959 dbSNP
rs541941280 1960 dbSNP
rs1191796951 1965 dbSNP
rs1373313964 1968 dbSNP
rs574660806 1969 dbSNP
rs1171596727 1987 dbSNP
rs1040459537 1989 dbSNP
rs1394237362 1989 dbSNP
rs1435318574 1989 dbSNP
rs944282691 1991 dbSNP
rs924840947 1998 dbSNP
rs1042003155 2001 dbSNP
rs535310560 2004 dbSNP
rs1366210872 2008 dbSNP
rs376369617 2016 dbSNP
rs1230883202 2017 dbSNP
rs553173360 2024 dbSNP
rs1347587673 2025 dbSNP
rs534822960 2043 dbSNP
rs1258321543 2049 dbSNP
rs991494218 2053 dbSNP
rs1349105438 2062 dbSNP
rs1204051983 2063 dbSNP
rs1261810701 2064 dbSNP
rs371904918 2066 dbSNP
rs958790519 2081 dbSNP
rs928629593 2093 dbSNP
rs1191334801 2097 dbSNP
rs981830474 2098 dbSNP
rs1177902599 2103 dbSNP
rs962097584 2107 dbSNP
rs577165660 2110 dbSNP
rs1158139105 2117 dbSNP
rs1389458231 2125 dbSNP
rs1437613904 2132 dbSNP
rs1324099643 2138 dbSNP
rs1238942383 2141 dbSNP
rs1268265269 2141 dbSNP
rs782423316 2141 dbSNP
rs1330566233 2149 dbSNP
rs558941810 2151 dbSNP
rs1468595936 2152 dbSNP
rs1192708492 2158 dbSNP
rs539443574 2160 dbSNP
rs1248148770 2169 dbSNP
rs1418494796 2175 dbSNP
rs1182413289 2181 dbSNP
rs1006180044 2182 dbSNP
rs1458915320 2184 dbSNP
rs951818447 2194 dbSNP
rs1028836270 2195 dbSNP
rs995895429 2199 dbSNP
rs901609238 2204 dbSNP
rs1458545663 2205 dbSNP
rs569269798 2207 dbSNP
rs1040151505 2213 dbSNP
rs999585920 2214 dbSNP
rs1371600919 2220 dbSNP
rs1391362840 2225 dbSNP
rs1289557825 2228 dbSNP
rs782240185 2231 dbSNP
rs1230933762 2233 dbSNP
rs902212425 2243 dbSNP
rs1322016629 2270 dbSNP
rs1041950427 2274 dbSNP
rs1223298156 2277 dbSNP
rs1249455791 2278 dbSNP
rs1480171911 2279 dbSNP
rs947644287 2281 dbSNP
rs1253918849 2282 dbSNP
rs550777126 2287 dbSNP
rs1474152929 2293 dbSNP
rs1185906206 2327 dbSNP
rs535915529 2332 dbSNP
rs568231501 2340 dbSNP
rs1417232663 2341 dbSNP
rs1424663628 2344 dbSNP
rs1167139448 2346 dbSNP
rs1352940116 2347 dbSNP
rs1461813376 2348 dbSNP
rs546749515 2352 dbSNP
rs1308950034 2355 dbSNP
rs1372948331 2356 dbSNP
rs1413466043 2361 dbSNP
rs914708696 2362 dbSNP
rs746748491 2367 dbSNP
rs528664617 2376 dbSNP
rs937534606 2380 dbSNP
rs928696433 2383 dbSNP
rs1228886176 2384 dbSNP
rs1276428943 2385 dbSNP
rs781956641 2388 dbSNP
rs1210042878 2394 dbSNP
rs537017102 2398 dbSNP
rs1483637688 2406 dbSNP
rs1183624082 2412 dbSNP
rs1417649775 2417 dbSNP
rs780070885 2418 dbSNP
rs1169695502 2423 dbSNP
rs149848082 2429 dbSNP
rs1433458708 2451 dbSNP
rs1173531992 2457 dbSNP
rs1360214472 2459 dbSNP
rs1449613275 2464 dbSNP
rs185549300 2469 dbSNP
rs1360844394 2473 dbSNP
rs984669957 2493 dbSNP
rs1435359605 2500 dbSNP
rs1299609202 2511 dbSNP
rs951953324 2519 dbSNP
rs1233241875 2520 dbSNP
rs1279272845 2521 dbSNP
rs1313820788 2523 dbSNP
rs1212338671 2526 dbSNP
rs782322275 2530 dbSNP
rs1240422952 2542 dbSNP
rs1464658637 2543 dbSNP
rs782187299 2553 dbSNP
rs1028808647 2567 dbSNP
rs1189433333 2585 dbSNP
rs1250338724 2587 dbSNP
rs374447891 2589 dbSNP
rs1172313956 2591 dbSNP
rs1426501212 2598 dbSNP
rs1416592052 2601 dbSNP
rs1156400724 2603 dbSNP
rs35014758 2605 dbSNP
rs1019104870 2622 dbSNP
rs4796722 2627 dbSNP
rs902137465 2633 dbSNP
rs1322171219 2634 dbSNP
rs1368274006 2656 dbSNP
rs1021925534 2660 dbSNP
rs1439911155 2665 dbSNP
rs1275148739 2680 dbSNP
rs1369721964 2688 dbSNP
rs114676860 2691 dbSNP
rs893370576 2701 dbSNP
rs1209395027 2702 dbSNP
rs1328540222 2702 dbSNP
rs1270276806 2704 dbSNP
rs373628980 2711 dbSNP
rs1467268892 2717 dbSNP
rs868950510 2720 dbSNP
rs1247655356 2722 dbSNP
rs1479324970 2723 dbSNP
rs1175957157 2729 dbSNP
rs1472643604 2729 dbSNP
rs181284484 2740 dbSNP
rs1391845091 2742 dbSNP
rs1460590110 2744 dbSNP
rs189341450 2752 dbSNP
rs1351382078 2764 dbSNP
rs370517497 2770 dbSNP
rs1439984598 2775 dbSNP
rs559495606 2778 dbSNP
rs1046190897 2790 dbSNP
rs1278921171 2796 dbSNP
rs1350982387 2800 dbSNP
rs1229103228 2805 dbSNP
rs940791619 2808 dbSNP
rs1290223524 2825 dbSNP
rs907845735 2832 dbSNP
rs1333056523 2843 dbSNP
rs1209454724 2867 dbSNP
rs984805911 2870 dbSNP
rs1291103894 2872 dbSNP
rs1453713155 2883 dbSNP
rs1202803387 2907 dbSNP
rs1251740845 2912 dbSNP
rs1473164386 2915 dbSNP
rs930655896 2916 dbSNP
rs921834873 2917 dbSNP
rs1472288875 2930 dbSNP
rs1163443893 2931 dbSNP
rs974694437 2933 dbSNP
rs1408024854 2935 dbSNP
rs1307119162 2943 dbSNP
rs966271423 2945 dbSNP
rs1371093015 2950 dbSNP
rs1411585045 2955 dbSNP
rs1310001509 2958 dbSNP
rs1353621814 2961 dbSNP
rs1244103683 2967 dbSNP
rs1285023654 2979 dbSNP
rs552928334 2981 dbSNP
rs541227137 2992 dbSNP
rs1358662365 3000 dbSNP
rs1213181347 3008 dbSNP
rs1274364224 3013 dbSNP
rs1207890781 3015 dbSNP
rs1254826470 3018 dbSNP
rs1441369347 3027 dbSNP
rs1187580135 3044 dbSNP
rs1238856467 3045 dbSNP
rs1018782939 3048 dbSNP
rs1474184482 3050 dbSNP
rs978211456 3063 dbSNP
rs1390551494 3064 dbSNP
rs782632547 3070 dbSNP
rs376476255 3072 dbSNP
rs1010514001 3082 dbSNP
rs894848609 3084 dbSNP
rs536052522 3088 dbSNP
rs558560080 3092 dbSNP
rs1395537012 3093 dbSNP
rs1334836143 3094 dbSNP
rs1342555114 3114 dbSNP
rs1433152941 3120 dbSNP
rs1297388270 3126 dbSNP
rs1034561249 3138 dbSNP
rs1278843493 3139 dbSNP
rs782811206 3145 dbSNP
rs782503049 3154 dbSNP
rs1257656080 3164 dbSNP
rs1444987015 3171 dbSNP
rs1248457720 3189 dbSNP
rs907327863 3191 dbSNP
rs536000318 3193 dbSNP
rs576281295 3194 dbSNP
rs1173292700 3195 dbSNP
rs1404414269 3199 dbSNP
rs1455879586 3202 dbSNP
rs1320176787 3217 dbSNP
rs1366144796 3217 dbSNP
rs1437744806 3222 dbSNP
rs1299562294 3223 dbSNP
rs1331103152 3226 dbSNP
rs1234591456 3233 dbSNP
rs1257301385 3236 dbSNP
rs1347886236 3240 dbSNP
rs1207511364 3255 dbSNP
rs940746225 3263 dbSNP
rs186015263 3279 dbSNP
rs1465920672 3287 dbSNP
rs1211655202 3288 dbSNP
rs1266389537 3293 dbSNP
rs1200874651 3301 dbSNP
rs1433749565 3301 dbSNP
rs1361951450 3306 dbSNP
rs1471663449 3309 dbSNP
rs535491628 3318 dbSNP
rs568169013 3323 dbSNP
rs1389667410 3337 dbSNP
rs1459017846 3342 dbSNP
rs1292207337 3348 dbSNP
rs1390441926 3348 dbSNP
rs782587665 3349 dbSNP
rs1304094903 3360 dbSNP
rs1349106231 3362 dbSNP
rs1227248431 3363 dbSNP
rs373822780 3364 dbSNP
rs1330841721 3370 dbSNP
rs781993043 3374 dbSNP
rs921969781 3404 dbSNP
rs553098454 3407 dbSNP
rs534877974 3417 dbSNP
rs34227257 3422 dbSNP
rs944648548 3429 dbSNP
rs182322087 3440 dbSNP
rs1482651141 3441 dbSNP
rs911687105 3445 dbSNP
rs782427099 3447 dbSNP
rs1181635888 3451 dbSNP
rs1412780692 3481 dbSNP
rs1162913762 3490 dbSNP
rs1368077896 3502 dbSNP
rs781901294 3508 dbSNP
rs1295582690 3512 dbSNP
rs1369315438 3518 dbSNP
rs1409732485 3532 dbSNP
rs1308158616 3554 dbSNP
rs1351764817 3573 dbSNP
rs966543972 3576 dbSNP
rs1226079073 3579 dbSNP
rs1311596743 3595 dbSNP
rs782794234 3598 dbSNP
rs1321885009 3601 dbSNP
rs1246726792 3607 dbSNP
rs1272207142 3612 dbSNP
rs1341439744 3619 dbSNP
rs1205759289 3623 dbSNP
rs1252682716 3635 dbSNP
rs1481679376 3640 dbSNP
rs782130829 3641 dbSNP
rs1180143908 3644 dbSNP
rs989229013 3646 dbSNP
rs1255738805 3647 dbSNP
rs958990691 3651 dbSNP
rs1167416809 3658 dbSNP
rs1033312124 3671 dbSNP
rs1388679903 3673 dbSNP
rs1002161785 3680 dbSNP
rs1429715754 3703 dbSNP
rs140939198 3704 dbSNP
rs6503671 3713 dbSNP
rs1445191639 3726 dbSNP
rs570267019 3729 dbSNP
rs1301683999 3735 dbSNP
rs1379530338 3756 dbSNP
rs1005040020 3765 dbSNP
rs1397405096 3769 dbSNP
rs1295194364 3771 dbSNP
rs886642513 3773 dbSNP
rs1364160561 3779 dbSNP
rs782735720 3780 dbSNP
rs1228821209 3788 dbSNP
rs1276719161 3792 dbSNP
rs1310311172 3795 dbSNP
rs1208188235 3797 dbSNP
rs994928005 3801 dbSNP
rs1185617848 3804 dbSNP
rs1246378807 3811 dbSNP
rs900470130 3819 dbSNP
rs1189546585 3833 dbSNP
rs1392569727 3834 dbSNP
rs1413264503 3838 dbSNP
rs1039047870 3842 dbSNP
rs782637427 3855 dbSNP
rs1174817764 3856 dbSNP
rs1359214828 3863 dbSNP
rs944598381 3874 dbSNP
rs1318171400 3877 dbSNP
rs1363954242 3878 dbSNP
rs190485755 3880 dbSNP
rs1299468424 3881 dbSNP
rs1365473213 3890 dbSNP
rs1218547798 3909 dbSNP
rs529764522 3912 dbSNP
rs544927081 3914 dbSNP
rs1205587740 3915 dbSNP
rs1266484169 3917 dbSNP
rs1464558326 3918 dbSNP
rs1209825172 3931 dbSNP
rs1244183498 3931 dbSNP
rs1477354773 3932 dbSNP
rs1191093598 3936 dbSNP
rs1426443733 3938 dbSNP
rs1481146989 3965 dbSNP
rs781920295 3969 dbSNP
rs1156249719 3970 dbSNP
rs1387462620 3981 dbSNP
rs1457427978 3989 dbSNP
rs915078260 3990 dbSNP
rs184311312 3994 dbSNP
rs1435438317 4002 dbSNP
rs1294065213 4005 dbSNP
rs1369567272 4006 dbSNP
rs147292302 4007 dbSNP
rs868916245 4018 dbSNP
rs1286525506 4034 dbSNP
rs551422904 4040 dbSNP
rs1229221233 4043 dbSNP
rs1286831726 4051 dbSNP
rs1450274265 4052 dbSNP
rs368017358 4064 dbSNP
rs374110167 4065 dbSNP
rs371654380 4066 dbSNP
rs1247819104 4072 dbSNP
rs199737901 4073 dbSNP
rs543268140 4074 dbSNP
rs1410550706 4090 dbSNP
rs1472735989 4091 dbSNP
rs144311899 4092 dbSNP
rs1411116717 4100 dbSNP
rs1404564241 4112 dbSNP
rs1323891428 4113 dbSNP
rs1351613227 4117 dbSNP
rs782603205 4119 dbSNP
rs1024553355 4120 dbSNP
rs1349916800 4128 dbSNP
rs1410474286 4145 dbSNP
rs1005588575 4149 dbSNP
rs140358950 4150 dbSNP
rs1354442997 4158 dbSNP
rs1228118070 4165 dbSNP
rs1362278136 4168 dbSNP
rs35447856 4168 dbSNP
rs1203587572 4172 dbSNP
rs1251673878 4173 dbSNP
rs1483107882 4183 dbSNP
rs1027833624 4198 dbSNP
rs1183274408 4200 dbSNP
rs1235386863 4212 dbSNP
rs541818372 4215 dbSNP
rs994893891 4226 dbSNP
rs1472258453 4237 dbSNP
rs1163682341 4242 dbSNP
rs782173238 4243 dbSNP
rs200432930 4248 dbSNP
rs1167918561 4253 dbSNP
rs1371038561 4256 dbSNP
rs1039553010 4270 dbSNP
rs1410620433 4282 dbSNP
rs1330904248 4294 dbSNP
rs1338999807 4295 dbSNP
rs1447562351 4298 dbSNP
rs1285194173 4300 dbSNP
rs797040801 4312 dbSNP
rs868992185 4313 dbSNP
rs549349908 4336 dbSNP
rs11079018 4342 dbSNP
rs1274566765 4343 dbSNP
rs1343412149 4350 dbSNP
rs11653094 4353 dbSNP
rs1042268490 4363 dbSNP
rs761383109 4368 dbSNP
rs1244559399 4371 dbSNP
rs150533891 4377 dbSNP
rs1187636832 4378 dbSNP
rs559069976 4394 dbSNP
rs1463461943 4399 dbSNP
rs1169788296 4424 dbSNP
rs141654993 4432 dbSNP
rs1413934665 4433 dbSNP
rs1337661291 4443 dbSNP
rs937868535 4448 dbSNP
rs1408494315 4449 dbSNP
rs1297312380 4464 dbSNP
rs1433353517 4464 dbSNP
rs926378168 4465 dbSNP
rs1230232088 4475 dbSNP
rs1272613561 4477 dbSNP
rs537254298 4480 dbSNP
rs1200484641 4481 dbSNP
rs148397441 4481 dbSNP
rs1463220506 4497 dbSNP
rs908210395 4505 dbSNP
rs1248400160 4514 dbSNP
rs544054381 4528 dbSNP
rs950957935 4532 dbSNP
rs1376945764 4541 dbSNP
rs1027801241 4543 dbSNP
rs1177158608 4555 dbSNP
rs1431802665 4560 dbSNP
rs1455830050 4562 dbSNP
rs973550612 4564 dbSNP
rs782485356 4566 dbSNP
rs1320361535 4569 dbSNP
rs1386092647 4570 dbSNP
rs1384235350 4580 dbSNP
rs1322173849 4587 dbSNP
rs1330972785 4592 dbSNP
rs548645312 4595 dbSNP
rs1223601071 4596 dbSNP
rs1009398940 4607 dbSNP
rs1326713783 4615 dbSNP
rs1227377330 4619 dbSNP
rs1268322459 4623 dbSNP
rs890428037 4637 dbSNP
rs781808632 4640 dbSNP
rs1207783280 4653 dbSNP
rs9896025 4665 dbSNP
rs1452102135 4669 dbSNP
rs1009413186 4670 dbSNP
rs1431513077 4673 dbSNP
rs1471756566 4676 dbSNP
rs1158747038 4699 dbSNP
rs1364552238 4700 dbSNP
rs1455687797 4701 dbSNP
rs1161757485 4705 dbSNP
rs1390732766 4717 dbSNP
rs1406079265 4719 dbSNP
rs1304485693 4720 dbSNP
rs1348057363 4727 dbSNP
rs1408631587 4729 dbSNP
rs1307274166 4730 dbSNP
rs893704407 4738 dbSNP
rs1053656641 4744 dbSNP
rs1360133890 4745 dbSNP
rs937840577 4762 dbSNP
rs1224588954 4764 dbSNP
rs1249480980 4774 dbSNP
rs905066306 4779 dbSNP
rs565710040 4784 dbSNP
rs111942712 4788 dbSNP
rs1251524405 4793 dbSNP
rs760533408 4794 dbSNP
rs1421106060 4797 dbSNP
rs949169104 4802 dbSNP
rs4796616 4819 dbSNP
rs75914986 4834 dbSNP
rs1425897761 4835 dbSNP
rs930991509 4843 dbSNP
rs1369181468 4848 dbSNP
rs920835602 4849 dbSNP
rs1428540561 4858 dbSNP
rs1298244442 4860 dbSNP
rs1375147282 4870 dbSNP
rs574282799 4881 dbSNP
rs1311791974 4888 dbSNP
rs1383297664 4892 dbSNP
rs1247834722 4893 dbSNP
rs1272408413 4899 dbSNP
rs1341292080 4907 dbSNP
rs1204000721 4909 dbSNP
rs1251955378 4910 dbSNP
rs1180307653 4922 dbSNP
rs1481771940 4922 dbSNP
rs1255690209 4926 dbSNP
rs1445629183 4933 dbSNP
rs782122431 4949 dbSNP
rs531452271 4952 dbSNP
rs1449377318 4953 dbSNP
rs1170591740 4958 dbSNP
rs1355740140 4965 dbSNP
rs1464069768 4966 dbSNP
rs561227043 4967 dbSNP
rs1406282245 4975 dbSNP
rs1454383022 4976 dbSNP
rs1295126920 4985 dbSNP
rs542546881 4989 dbSNP
rs1364446912 4997 dbSNP
rs574470090 5008 dbSNP
rs1296439870 5010 dbSNP
rs8066947 5011 dbSNP
rs1208033446 5021 dbSNP
rs1021016269 5038 dbSNP
rs77331851 5041 dbSNP
rs1461935501 5053 dbSNP
rs782351568 5057 dbSNP
rs1246547857 5058 dbSNP
rs1485849519 5059 dbSNP
rs1187647457 5067 dbSNP
rs1422210731 5070 dbSNP
rs1430965197 5072 dbSNP
rs1174668275 5077 dbSNP
rs1429640267 5081 dbSNP
rs4796615 5082 dbSNP
rs1318353052 5083 dbSNP
rs1387600312 5090 dbSNP
rs1431148667 5092 dbSNP
rs958064766 5097 dbSNP
rs1290589283 5098 dbSNP
rs774251602 5104 dbSNP
rs1365317528 5107 dbSNP
rs1044777 5108 dbSNP
rs1217607733 5114 dbSNP
rs1282708883 5138 dbSNP
rs781912184 5148 dbSNP
rs782429945 5153 dbSNP
rs782269338 5157 dbSNP
rs1266427950 5165 dbSNP
rs1316719519 5181 dbSNP
rs904993136 5187 dbSNP
rs1046675185 5190 dbSNP
rs1216879768 5200 dbSNP
rs1013312454 5210 dbSNP
rs1487790164 5214 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuaUUCUGGUAGAAAAGGAGuu 5'
             |||  | || |||||||  
Target 5' -ucAAG--C-UCCUUUCCUC-- 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000319121.3 | 3UTR | UCAAGCUCCUUUCCUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-3915 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059544 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 2 2
MIRT081703 ZNF507 zinc finger protein 507 2 2
MIRT083311 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT119046 SFT2D3 SFT2 domain containing 3 2 2
MIRT189381 TXLNA taxilin alpha 2 4
MIRT195895 C16ORF72 chromosome 16 open reading frame 72 2 6
MIRT223807 OXR1 oxidation resistance 1 2 2
MIRT292954 ZNF146 zinc finger protein 146 2 4
MIRT293949 RPL13A ribosomal protein L13a 2 6
MIRT300900 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT339332 SESN2 sestrin 2 2 2
MIRT349304 ZNF317 zinc finger protein 317 2 2
MIRT364736 TOR1B torsin family 1 member B 2 2
MIRT366233 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT384605 CLIC4 chloride intracellular channel 4 2 2
MIRT401745 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT443169 UBL3 ubiquitin like 3 2 2
MIRT444215 METTL12 methyltransferase like 12 2 2
MIRT444375 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT445340 TCEANC transcription elongation factor A N-terminal and central domain containing 2 2
MIRT445474 KDM6A lysine demethylase 6A 2 2
MIRT445598 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT445630 TMEM50A transmembrane protein 50A 2 2
MIRT446012 VNN1 vanin 1 2 2
MIRT446115 ASTN1 astrotactin 1 2 2
MIRT446248 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT446382 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT446940 ZMAT3 zinc finger matrin-type 3 2 2
MIRT446967 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT447178 PGRMC2 progesterone receptor membrane component 2 2 2
MIRT447209 APBB2 amyloid beta precursor protein binding family B member 2 2 2
MIRT447237 IHH indian hedgehog 2 2
MIRT447807 EMX1 empty spiracles homeobox 1 2 2
MIRT447853 RRP8 ribosomal RNA processing 8 2 4
MIRT448054 MMP15 matrix metallopeptidase 15 2 2
MIRT448094 RASD2 RASD family member 2 2 2
MIRT448704 KLHL11 kelch like family member 11 2 2
MIRT448851 FEM1C fem-1 homolog C 2 2
MIRT449488 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT449785 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT450774 PDE3A phosphodiesterase 3A 2 2
MIRT451124 ZNF99 zinc finger protein 99 2 2
MIRT452676 GPR156 G protein-coupled receptor 156 2 2
MIRT452888 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT453188 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453353 ZNF3 zinc finger protein 3 2 2
MIRT454502 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454629 FAM83H family with sequence similarity 83 member H 2 2
MIRT455183 AGTRAP angiotensin II receptor associated protein 2 2
MIRT458204 FOXL2 forkhead box L2 2 2
MIRT458723 CES2 carboxylesterase 2 2 2
MIRT458942 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460304 FLCN folliculin 2 2
MIRT460989 SYT7 synaptotagmin 7 2 2
MIRT461697 ZNF426 zinc finger protein 426 2 2
MIRT461903 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462193 NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 2 2
MIRT462290 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT463795 XPOT exportin for tRNA 2 2
MIRT464649 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 4
MIRT465911 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 4
MIRT465992 TMEM189 transmembrane protein 189 2 4
MIRT466302 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466575 TBC1D2B TBC1 domain family member 2B 2 2
MIRT470558 POU2F1 POU class 2 homeobox 1 2 2
MIRT471333 PERP PERP, TP53 apoptosis effector 2 2
MIRT471659 PALM2 paralemmin 2 2 2
MIRT472363 TSPAN1 tetraspanin 1 2 2
MIRT473468 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT474702 KIF3A kinesin family member 3A 2 2
MIRT476067 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT476077 GRB2 growth factor receptor bound protein 2 2 2
MIRT476423 GBA2 glucosylceramidase beta 2 2 2
MIRT476463 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477877 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT478240 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT479460 CDK6 cyclin dependent kinase 6 2 2
MIRT481030 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT491496 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT497585 SLC23A1 solute carrier family 23 member 1 2 2
MIRT498542 TMEM30B transmembrane protein 30B 2 2
MIRT499263 NBPF11 NBPF member 11 2 2
MIRT504698 ZNF117 zinc finger protein 117 2 2
MIRT511288 KLHL15 kelch like family member 15 2 4
MIRT523121 HSP90B1 heat shock protein 90 beta family member 1 2 4
MIRT529601 H1F0 H1 histone family member 0 2 2
MIRT533481 TRIM71 tripartite motif containing 71 2 2
MIRT535571 NUP37 nucleoporin 37 2 4
MIRT537869 EDA2R ectodysplasin A2 receptor 2 2
MIRT538010 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552681 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 4
MIRT554986 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT556659 KMT2D lysine methyltransferase 2D 2 4
MIRT557437 GTPBP2 GTP binding protein 2 2 2
MIRT560813 CRTAP cartilage associated protein 2 2
MIRT562115 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563103 IFRD2 interferon related developmental regulator 2 2 2
MIRT574199 LMNB1 lamin B1 2 2
MIRT623920 FMNL3 formin like 3 2 2
MIRT626551 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2 2
MIRT645458 ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 2 2
MIRT649082 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT659477 CLDN1 claudin 1 2 2
MIRT667950 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 2
MIRT701981 MIER3 MIER family member 3 2 2
MIRT708694 TFDP2 transcription factor Dp-2 2 2
MIRT709649 DFFB DNA fragmentation factor subunit beta 2 2
MIRT710090 FAM229B family with sequence similarity 229 member B 2 2
MIRT718396 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT724972 TNS1 tensin 1 2 2
MIRT756050 HRH4 histamine receptor H4 2 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3915 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-3915 Cisplatin + Decitabine sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-mir-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-3915 Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3915 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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