miRTarBase - #MIRT448860


—
pre-miRNA Information
pre-miRNA hsa-mir-4291   
Genomic Coordinates chr9: 93819357 - 93819421
Description Homo sapiens miR-4291 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4291
Sequence 11| UUCAGCAGGAACAGCU |26
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1265713434 9 dbSNP
rs1433969451 12 dbSNP
rs1372852268 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FAM49B   
Synonyms BM-009, L1
Description family with sequence similarity 49 member B
Transcript NM_016623   
Expression
Putative miRNA Targets on FAM49B
3'UTR of FAM49B
(miRNA target sites are highlighted)		 
>FAM49B|NM_016623|3'UTR
   1 CAATTCTGGAATAAGCACCTGCTGTAGACAGAAGACAGTATTCTGCAATGACTGAGAATGCAGTTTTTTAGTGATTGCAA
  81 TTACTATCTCATTTATTCTTGCTTTTATTTCTTTCCTCTGTTCCTCTTCCCTCTTTTTTAATCATGTTCTTAAGACTTCT
 161 TTTCTGTGCCAAAATCAGTAAAGTTACACTCTGAAGGGATATCATCCTTTCAAACGGGCCATCTAAGGCAGCTAATTATG
 241 CATTGCATTGGGGTCTCTACTGAGAAAAATTCTGTGACTTGAACTAAATATTTTTAAATGTGGATTTTTTTTGAAACTAA
 321 TATTTAATATTGCTTCTCCTGCATGGCAAAACTGCCTATTCTGCTATTTAAAAACCCTCAATGACTTTATTTTCTACTGC
 401 CGCCTTTTTCATGTGCAACCAAAATGAAAATGTTTAAATTAACTGTGTTGTACAAATGGTACCCAACACAAACTTTTTTT
 481 AAATTAGTAATACTTTTGTTTAAAGTTTTAAGTTTGCATTTTGACTTTTTTTGTAAGGATGTATGTTGTGTGTTTAACCT
 561 TTATTAACTAACGTTAAAAGCTGTGATGTGTGCGTAGAATATTACGTATGCATGTTCATGTCTAAAGAATGGCTGTTGAT
 641 GATAAAATAAAAATCAGCTTTCATTTTTCTAAGTGTGGCTTGGTTTACTGATGTTTTGTTTTTAGGCTTCTGAAGTTTTC
 721 CCCATGTATGTTTTTATGGAATGCATATATACATTACATGATTTTTTCTTCTTTTAGGGGAGAGCCGGGTCTTTTCATTA
 801 GAATTTTGATCATTGTCTATGTATATACTTTTAATTGCCTTTAAAATTTTGCTAAGTATATTAAGACCAGTGATCTTTTC
 881 ATTAACTGGACTTTTATTCTTGATTTACTCTTGTATGGATGTAGTAATGGAAGGAAAACCGCATCCTTGCTTGATTCTCC
 961 ATTTCCAGGGGAGCGGGTAGCAACATGAAGGCAGAGTAGCCCTTTAATCATGGGAAGAGAGTGATTATAAGAGGGACTTC
1041 CCAGGAGAAAAGCAGAGGCCATGATCTCACTAGTGGTAGAAAACTAACAGGTTTCAGTTTAAGATCATAAAACCTAAATC
1121 ATGAAATCTAAATCTCATGGTTGGAACAAACTACTTAAAGGTTGTCTAGTTCAACCATGCCAGTGTTTTAAATATTTAGG
1201 AATATCCGAGGTATAATACAATTAAAATGTTTAACCATGGAAGAGAATCACAGAGGCTTCCATCAGACCCTTCTGGATTA
1281 ATAGGGCCAGATCATGGCACACACAGCTTCTCAAGATCACATCCCTGCTGATCTCTCTGGCCCTCCTGATCACTGCTCCC
1361 CCACTTCACACCCTGTCCTGCAGCCAGGCCCTACTGCTTGCTGTTCACAAATTGTTCCATGTGATGTCACTTCCTTAGCT
1441 CTGGTCTGGCTGGTCCCTGAACCTGACATTCCCTTCCTCCCCTTGTGACCCTCTAATGAACGCCAACTTTCATCTTTGAA
1521 GGGTTAGCTTCTATTACCTCCTTCATGAAGCCTTCTGGATAACATTGGCCATATCCTTCTAGGCATCTTCTAAGAATAGT
1601 GTAATAGGCTGAATAGTGGCCCCCAGGAGATACATTCACTGGGAATCTCCACGTGTGACATTATTTGGAAAAAGTTTTTG
1681 CAGATGAAATCAAGGACCTGGAAATGAGATCAACCTGTAGTAGGGTGGGCCCTAAATTCAATGACTAGCTCTTAGAAAAG
1761 AAGGGGAAATAGACACACAGAGCTGAAGGCCATGGGAAGATGGAGGCAGAGATTAGAGCAATGCATCTATGAGCCAAAGA
1841 ACCCTAAGAATTGGAGGAAGTCACTAGAAGCTAGGAAAACAGGCATGTCACAGATTCTCCCTCAGAGTCTCGAGAAGGAA
1921 CCAACCCTACCAATATCTTGATTTCAGACATCTGGCCTCCAGGATTGTGAGGGAATAAATTTCTGTTGTTTTAAGCCATG
2001 CAGTTTGTGGTATTTTGGTACAGCAGCCTTAAGAATCTGATACATGTATCTCGTAAAACACCTCTGATACTTACCTGCGC
2081 TTGTGGCTGTGTTTTCTGATACTATGAGAGCCGTAGTATCTGGATACCGGAGAGTCTGCGAACTTGAGAGAAGGGCCGTG
2161 TCTGATTTTCCTTCAGTGTCCCAAGGAAGGATCTTGCACAGTACCCAGATTTGGAGAGGTGCCAAGTGAATGCTTCGGTG
2241 GACTGAATGAATACAAATCAAAAATAATGATGCAGCGGGAATGGATGCAGTAAGATTGCTGTGGCCTATGCAGTTCACAC
2321 AGTTCACACTCTGCATGTTGAGGAGTAAGTGGACAGATCTCTTAAGCCCAGGGGCTAGCAAACCGGTCTGTGGGCCAATT
2401 TACTCACCGTCTGTTTTTGTACAGCTTGTGAGCTAAAAATGGTTTTTAAAAAGGTTGAATACAATCAAAAGAATAATATT
2481 TTGTGGCATGAGAAAAGCATATGAAATTCAAATTTTAGTGTTCATAAATAAAATTTTATTGGAACCTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgacAAGGACGACUu 5'
               | |||||||| 
Target 5' tcacaTCCCTGCTGAt 3'
 1317 - 1332 147.00 -12.40
2 
miRNA  3' ucgacaaGGACGACuu 5'
                 |||||||  
Target 5' ataagcaCCTGCTGta 3'
 11 - 26 125.00 -12.20
3 
miRNA  3' ucgacaagGACGACUu 5'
                  |||:||| 
Target 5' aagaatggCTGTTGAt 3'
 625 - 640 124.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31537143 22 COSMIC
COSN30529827 30 COSMIC
COSN30100956 35 COSMIC
COSN31608634 56 COSMIC
COSN31551773 62 COSMIC
COSN31534384 84 COSMIC
COSN30475872 90 COSMIC
COSN30475810 91 COSMIC
COSN31571681 102 COSMIC
COSN24311463 111 COSMIC
COSN30167411 111 COSMIC
COSN31563955 124 COSMIC
COSN31525221 149 COSMIC
COSN5108797 156 COSMIC
COSN8065938 190 COSMIC
COSN30127401 206 COSMIC
COSN30367258 222 COSMIC
COSN26188730 296 COSMIC
COSN31542706 313 COSMIC
COSN31960074 325 COSMIC
COSN15734341 329 COSMIC
COSN31601002 338 COSMIC
COSN31484084 358 COSMIC
COSN26641962 572 COSMIC
COSN31593067 573 COSMIC
COSN31582891 593 COSMIC
COSN6912446 753 COSMIC
COSN16190995 979 COSMIC
COSN2261173 1229 COSMIC
COSN24206883 1476 COSMIC
COSN21970480 1652 COSMIC
COSN32210725 1848 COSMIC
COSN25614499 2073 COSMIC
COSN29186956 2340 COSMIC
COSN9598057 2524 COSMIC
rs837065 941 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1214809115 9 dbSNP
rs759327459 23 dbSNP
rs1264950913 29 dbSNP
rs376567124 30 dbSNP
rs767972456 36 dbSNP
rs1420304734 37 dbSNP
rs762048885 38 dbSNP
rs770129388 39 dbSNP
rs774950285 40 dbSNP
rs768992845 45 dbSNP
rs1269759855 46 dbSNP
rs749381008 48 dbSNP
rs1166825210 54 dbSNP
rs1387256888 58 dbSNP
rs1305040156 63 dbSNP
rs1323888402 80 dbSNP
rs1438230872 84 dbSNP
rs1393345996 86 dbSNP
rs1331784254 94 dbSNP
rs1434193850 96 dbSNP
rs1290610231 101 dbSNP
rs1365250231 102 dbSNP
rs1433663723 105 dbSNP
rs1411449923 107 dbSNP
rs1361084711 110 dbSNP
rs777242601 115 dbSNP
rs1289615890 120 dbSNP
rs1320359029 123 dbSNP
rs533224480 143 dbSNP
rs1394172015 164 dbSNP
rs377477451 171 dbSNP
rs1167289519 180 dbSNP
rs1475105142 187 dbSNP
rs1464856119 188 dbSNP
rs999347435 193 dbSNP
rs1445460541 199 dbSNP
rs1162947779 205 dbSNP
rs1046125177 206 dbSNP
rs1412771499 215 dbSNP
rs768080103 216 dbSNP
rs1051869327 217 dbSNP
rs771589772 219 dbSNP
rs1389226219 227 dbSNP
rs1456654538 232 dbSNP
rs559224429 237 dbSNP
rs540784995 238 dbSNP
rs932026029 239 dbSNP
rs1252684078 251 dbSNP
rs1179579278 252 dbSNP
rs1376552339 253 dbSNP
rs1225778828 254 dbSNP
rs1269173190 255 dbSNP
rs1328997957 256 dbSNP
rs936849315 257 dbSNP
rs1443125384 259 dbSNP
rs921411044 268 dbSNP
rs975536531 272 dbSNP
rs1271452999 278 dbSNP
rs965630982 280 dbSNP
rs77815425 295 dbSNP
rs983225038 298 dbSNP
rs1412444507 299 dbSNP
rs1456638330 299 dbSNP
rs1156931938 304 dbSNP
rs1414498981 313 dbSNP
rs561591486 313 dbSNP
rs908114473 313 dbSNP
rs984051564 320 dbSNP
rs543095663 322 dbSNP
rs567481443 336 dbSNP
rs928768678 343 dbSNP
rs563673534 346 dbSNP
rs1309544540 352 dbSNP
rs1285796385 353 dbSNP
rs773449866 363 dbSNP
rs1444040590 373 dbSNP
rs974154925 376 dbSNP
rs774860777 381 dbSNP
rs772551420 396 dbSNP
rs1033535950 401 dbSNP
rs545077256 411 dbSNP
rs957971916 413 dbSNP
rs1030894002 414 dbSNP
rs1478321437 422 dbSNP
rs999819987 424 dbSNP
rs1002024602 425 dbSNP
rs1411281483 430 dbSNP
rs906482450 432 dbSNP
rs1308309428 440 dbSNP
rs1175597401 443 dbSNP
rs890304329 450 dbSNP
rs1408344526 451 dbSNP
rs1024853788 453 dbSNP
rs1030540859 455 dbSNP
rs1009655902 459 dbSNP
rs1332124342 470 dbSNP
rs1233167504 481 dbSNP
rs1432949759 481 dbSNP
rs1273150714 487 dbSNP
rs578240102 488 dbSNP
rs78985668 496 dbSNP
rs1159397339 508 dbSNP
rs1202686412 509 dbSNP
rs1471302891 509 dbSNP
rs1269203377 518 dbSNP
rs560581784 526 dbSNP
rs1452097688 528 dbSNP
rs900579789 530 dbSNP
rs535387943 543 dbSNP
rs189588525 550 dbSNP
rs1037737247 551 dbSNP
rs1231508515 556 dbSNP
rs1450847160 564 dbSNP
rs555717112 565 dbSNP
rs748301581 572 dbSNP
rs781603354 573 dbSNP
rs537114958 593 dbSNP
rs779151839 594 dbSNP
rs899581248 596 dbSNP
rs1386699138 605 dbSNP
rs1322186902 608 dbSNP
rs941994128 618 dbSNP
rs1435837309 624 dbSNP
rs1039886083 628 dbSNP
rs1286241630 639 dbSNP
rs944205481 652 dbSNP
rs1047989912 657 dbSNP
rs569671528 663 dbSNP
rs551309107 664 dbSNP
rs10050 669 dbSNP
rs1209143636 679 dbSNP
rs983018565 707 dbSNP
rs1448572591 717 dbSNP
rs1188568585 720 dbSNP
rs1246895400 721 dbSNP
rs185861903 723 dbSNP
rs928856289 724 dbSNP
rs938891521 724 dbSNP
rs1357218990 732 dbSNP
rs539054271 733 dbSNP
rs1161848132 737 dbSNP
rs1391390487 741 dbSNP
rs929979300 744 dbSNP
rs1458245741 749 dbSNP
rs1319960730 753 dbSNP
rs182464708 758 dbSNP
rs919913555 766 dbSNP
rs974461338 768 dbSNP
rs1397976613 770 dbSNP
rs1412961940 776 dbSNP
rs1340121850 777 dbSNP
rs755019246 786 dbSNP
rs190240268 787 dbSNP
rs529187603 788 dbSNP
rs1331059325 792 dbSNP
rs958805786 803 dbSNP
rs1266930190 810 dbSNP
rs1406142417 814 dbSNP
rs1183212290 815 dbSNP
rs749401349 819 dbSNP
rs1158283860 820 dbSNP
rs561889086 823 dbSNP
rs1475745784 828 dbSNP
rs957712592 831 dbSNP
rs1031049110 832 dbSNP
rs1186458442 854 dbSNP
rs1473204430 869 dbSNP
rs1159130275 876 dbSNP
rs1386517742 878 dbSNP
rs970515339 888 dbSNP
rs978038819 895 dbSNP
rs954786222 899 dbSNP
rs184359263 901 dbSNP
rs1291195851 905 dbSNP
rs191877834 908 dbSNP
rs1217388660 913 dbSNP
rs1444922609 915 dbSNP
rs996399362 916 dbSNP
rs1256094031 920 dbSNP
rs1283126911 922 dbSNP
rs900614061 938 dbSNP
rs1198442545 940 dbSNP
rs837065 941 dbSNP
rs1032037569 954 dbSNP
rs188913107 955 dbSNP
rs750443130 957 dbSNP
rs899633674 959 dbSNP
rs115438839 960 dbSNP
rs1232580059 966 dbSNP
rs944215545 971 dbSNP
rs767203718 974 dbSNP
rs1432980115 975 dbSNP
rs1372150757 984 dbSNP
rs948907701 985 dbSNP
rs914713333 986 dbSNP
rs1371001189 987 dbSNP
rs1220938602 994 dbSNP
rs1343594048 999 dbSNP
rs1301361700 1002 dbSNP
rs1047779788 1013 dbSNP
rs930265899 1019 dbSNP
rs1276276515 1020 dbSNP
rs1317928413 1032 dbSNP
rs936386695 1033 dbSNP
rs1204804044 1040 dbSNP
rs923670509 1041 dbSNP
rs184120507 1051 dbSNP
rs530169438 1054 dbSNP
rs1163291199 1058 dbSNP
rs1431558781 1063 dbSNP
rs1170586677 1064 dbSNP
rs920159059 1065 dbSNP
rs1475161178 1078 dbSNP
rs1167717792 1084 dbSNP
rs978154130 1086 dbSNP
rs954679196 1088 dbSNP
rs1294095968 1091 dbSNP
rs1187695169 1115 dbSNP
rs1038406126 1121 dbSNP
rs937322428 1128 dbSNP
rs747417936 1135 dbSNP
rs780235638 1136 dbSNP
rs1342364413 1138 dbSNP
rs1227287405 1139 dbSNP
rs1016072207 1145 dbSNP
rs964555603 1145 dbSNP
rs1213964016 1146 dbSNP
rs1006347155 1147 dbSNP
rs970567832 1149 dbSNP
rs1265318460 1153 dbSNP
rs917782724 1158 dbSNP
rs1469574566 1160 dbSNP
rs1248734829 1176 dbSNP
rs139373792 1177 dbSNP
rs541729652 1180 dbSNP
rs1186957969 1182 dbSNP
rs191598146 1188 dbSNP
rs950768487 1202 dbSNP
rs1349166399 1203 dbSNP
rs758644483 1207 dbSNP
rs1297651171 1208 dbSNP
rs956684771 1210 dbSNP
rs187961028 1211 dbSNP
rs1433862445 1213 dbSNP
rs1359988221 1215 dbSNP
rs1268096797 1225 dbSNP
rs73710949 1226 dbSNP
rs1457561969 1229 dbSNP
rs1003265471 1233 dbSNP
rs1312461207 1237 dbSNP
rs182438271 1238 dbSNP
rs963645642 1251 dbSNP
rs557555853 1262 dbSNP
rs562658190 1271 dbSNP
rs1464541953 1272 dbSNP
rs1045054933 1290 dbSNP
rs1017991068 1291 dbSNP
rs1239393212 1299 dbSNP
rs1013087082 1305 dbSNP
rs1007907057 1306 dbSNP
rs893306905 1314 dbSNP
rs750431242 1321 dbSNP
rs1412873971 1323 dbSNP
rs1474182479 1327 dbSNP
rs1047255522 1330 dbSNP
rs1373543732 1331 dbSNP
rs1324301391 1344 dbSNP
rs1456202211 1345 dbSNP
rs751145342 1348 dbSNP
rs1461256216 1356 dbSNP
rs1448313892 1358 dbSNP
rs1283957042 1361 dbSNP
rs539191773 1362 dbSNP
rs1173193649 1363 dbSNP
rs1230756654 1363 dbSNP
rs1329116102 1364 dbSNP
rs1038597537 1366 dbSNP
rs1222080189 1372 dbSNP
rs1280847040 1378 dbSNP
rs1407673540 1383 dbSNP
rs937338822 1389 dbSNP
rs1209762962 1393 dbSNP
rs927256547 1393 dbSNP
rs1045745766 1398 dbSNP
rs1484596435 1407 dbSNP
rs1418128002 1408 dbSNP
rs1412568688 1410 dbSNP
rs544370911 1430 dbSNP
rs1455302453 1433 dbSNP
rs141908848 1439 dbSNP
rs1426726499 1444 dbSNP
rs1414673713 1445 dbSNP
rs988033286 1447 dbSNP
rs1192710482 1449 dbSNP
rs1333157685 1461 dbSNP
rs933001207 1467 dbSNP
rs956709070 1475 dbSNP
rs925229553 1482 dbSNP
rs1412024087 1485 dbSNP
rs71570502 1488 dbSNP
rs1309024108 1495 dbSNP
rs16904157 1497 dbSNP
rs963697679 1501 dbSNP
rs371953787 1506 dbSNP
rs1345853436 1509 dbSNP
rs766924433 1520 dbSNP
rs1252958005 1522 dbSNP
rs139826181 1527 dbSNP
rs1344617850 1533 dbSNP
rs527336159 1535 dbSNP
rs955184701 1541 dbSNP
rs984608194 1551 dbSNP
rs1252288294 1553 dbSNP
rs950850399 1559 dbSNP
rs1179654741 1562 dbSNP
rs1247928605 1568 dbSNP
rs1025812577 1576 dbSNP
rs764196251 1581 dbSNP
rs994349132 1592 dbSNP
rs1026832501 1597 dbSNP
rs898630825 1600 dbSNP
rs1002930221 1601 dbSNP
rs1038652076 1605 dbSNP
rs1001810573 1606 dbSNP
rs1326170830 1608 dbSNP
rs1022881246 1619 dbSNP
rs1301343156 1620 dbSNP
rs1013161470 1627 dbSNP
rs906102091 1630 dbSNP
rs1373389227 1632 dbSNP
rs1301542363 1634 dbSNP
rs193263489 1635 dbSNP
rs1193881629 1636 dbSNP
rs1054581475 1637 dbSNP
rs549909887 1642 dbSNP
rs1192398837 1649 dbSNP
rs531397592 1652 dbSNP
rs903329504 1653 dbSNP
rs891883204 1655 dbSNP
rs564353153 1660 dbSNP
rs551884458 1663 dbSNP
rs1354536835 1671 dbSNP
rs1391997656 1674 dbSNP
rs925095540 1683 dbSNP
rs188591838 1684 dbSNP
rs942651191 1690 dbSNP
rs911130927 1695 dbSNP
rs116709284 1704 dbSNP
rs150637072 1706 dbSNP
rs1224889431 1721 dbSNP
rs1285750631 1734 dbSNP
rs1025404926 1735 dbSNP
rs929144169 1736 dbSNP
rs141961920 1738 dbSNP
rs1270697962 1739 dbSNP
rs1465902282 1741 dbSNP
rs1252374684 1764 dbSNP
rs981935009 1774 dbSNP
rs183357849 1777 dbSNP
rs544134637 1780 dbSNP
rs1369463002 1783 dbSNP
rs991436980 1790 dbSNP
rs1001694198 1796 dbSNP
rs1475162233 1801 dbSNP
rs148146345 1811 dbSNP
rs1350174590 1812 dbSNP
rs553692699 1813 dbSNP
rs1232770315 1825 dbSNP
rs1382997042 1829 dbSNP
rs1024521551 1834 dbSNP
rs1398067667 1837 dbSNP
rs1335933036 1839 dbSNP
rs77357301 1840 dbSNP
rs369321644 1844 dbSNP
rs1291306377 1855 dbSNP
rs1228400825 1862 dbSNP
rs1259641796 1864 dbSNP
rs1484679530 1865 dbSNP
rs903360690 1866 dbSNP
rs1029792695 1867 dbSNP
rs1485575929 1869 dbSNP
rs571833243 1871 dbSNP
rs1414750494 1876 dbSNP
rs553307235 1880 dbSNP
rs936109413 1883 dbSNP
rs904605247 1885 dbSNP
rs1467747165 1889 dbSNP
rs1043575168 1897 dbSNP
rs1350343420 1904 dbSNP
rs1413896756 1911 dbSNP
rs943031744 1921 dbSNP
rs1352194309 1924 dbSNP
rs887411045 1926 dbSNP
rs867895621 1927 dbSNP
rs1305663648 1931 dbSNP
rs1314652365 1935 dbSNP
rs1049014670 1936 dbSNP
rs535092468 1939 dbSNP
rs1256170913 1949 dbSNP
rs1416043066 1951 dbSNP
rs1373061908 1961 dbSNP
rs929199142 1966 dbSNP
rs942534920 1983 dbSNP
rs1177177906 1985 dbSNP
rs1311794295 1985 dbSNP
rs1453987777 1988 dbSNP
rs568090204 1995 dbSNP
rs1176919912 1996 dbSNP
rs911140765 1998 dbSNP
rs768887299 2001 dbSNP
rs1433108711 2005 dbSNP
rs1485609200 2010 dbSNP
rs987088044 2013 dbSNP
rs1156591594 2021 dbSNP
rs1372247169 2027 dbSNP
rs950208905 2027 dbSNP
rs1418301810 2032 dbSNP
rs915977981 2033 dbSNP
rs760523861 2038 dbSNP
rs749306113 2041 dbSNP
rs545225932 2042 dbSNP
rs113439969 2044 dbSNP
rs918269860 2050 dbSNP
rs756277404 2052 dbSNP
rs972412634 2053 dbSNP
rs538169712 2055 dbSNP
rs1369776578 2061 dbSNP
rs1016689631 2062 dbSNP
rs1032943682 2066 dbSNP
rs1190019751 2068 dbSNP
rs980266389 2070 dbSNP
rs978080742 2071 dbSNP
rs967654543 2074 dbSNP
rs1250086670 2075 dbSNP
rs1030270884 2078 dbSNP
rs970178154 2079 dbSNP
rs570538274 2080 dbSNP
rs1255464418 2087 dbSNP
rs1024578892 2088 dbSNP
rs1200009126 2095 dbSNP
rs899975802 2099 dbSNP
rs1190792244 2103 dbSNP
rs1391757063 2104 dbSNP
rs533573630 2112 dbSNP
rs1014898928 2113 dbSNP
rs1017376873 2116 dbSNP
rs112990366 2118 dbSNP
rs1352635015 2119 dbSNP
rs887443881 2124 dbSNP
rs781231080 2128 dbSNP
rs1237273087 2129 dbSNP
rs1000194132 2131 dbSNP
rs1438234381 2136 dbSNP
rs1299296920 2138 dbSNP
rs1328938333 2139 dbSNP
rs1294327581 2140 dbSNP
rs1048718590 2144 dbSNP
rs1293895427 2147 dbSNP
rs1324015651 2151 dbSNP
rs904656139 2157 dbSNP
rs147079747 2158 dbSNP
rs1272588853 2160 dbSNP
rs1006686549 2172 dbSNP
rs1210693001 2175 dbSNP
rs1248835392 2176 dbSNP
rs1475217818 2177 dbSNP
rs1185704834 2178 dbSNP
rs1382306883 2181 dbSNP
rs1417215244 2186 dbSNP
rs889593702 2196 dbSNP
rs1050929587 2198 dbSNP
rs1459379124 2200 dbSNP
rs558193195 2202 dbSNP
rs534037210 2205 dbSNP
rs1321980231 2206 dbSNP
rs143327860 2209 dbSNP
rs933929768 2221 dbSNP
rs190795857 2226 dbSNP
rs1345353214 2227 dbSNP
rs547771829 2233 dbSNP
rs915716454 2234 dbSNP
rs1037143392 2236 dbSNP
rs936050304 2238 dbSNP
rs529260958 2240 dbSNP
rs376135048 2243 dbSNP
rs554603406 2243 dbSNP
rs1417083793 2253 dbSNP
rs968057053 2254 dbSNP
rs1186855370 2255 dbSNP
rs1446637020 2259 dbSNP
rs186028878 2267 dbSNP
rs1240126138 2268 dbSNP
rs199703820 2269 dbSNP
rs977377591 2270 dbSNP
rs118187226 2273 dbSNP
rs139302201 2276 dbSNP
rs917431273 2277 dbSNP
rs1408163336 2286 dbSNP
rs951767397 2289 dbSNP
rs993000401 2300 dbSNP
rs1274180911 2304 dbSNP
rs1156549528 2306 dbSNP
rs115949023 2308 dbSNP
rs1333248510 2313 dbSNP
rs1031921742 2314 dbSNP
rs758130596 2316 dbSNP
rs1312655762 2330 dbSNP
rs759228022 2332 dbSNP
rs1327714438 2335 dbSNP
rs1280181902 2338 dbSNP
rs1017656384 2339 dbSNP
rs1007622551 2340 dbSNP
rs146943965 2342 dbSNP
rs1280951150 2343 dbSNP
rs1371356705 2347 dbSNP
rs1211267163 2364 dbSNP
rs1051403158 2365 dbSNP
rs1484647110 2369 dbSNP
rs182772311 2371 dbSNP
rs894318432 2374 dbSNP
rs1055552081 2376 dbSNP
rs1175001654 2377 dbSNP
rs1396437160 2381 dbSNP
rs998025855 2384 dbSNP
rs1173403395 2385 dbSNP
rs191062044 2388 dbSNP
rs1432149779 2390 dbSNP
rs1042168957 2394 dbSNP
rs1335719524 2395 dbSNP
rs1389865289 2398 dbSNP
rs1036914172 2404 dbSNP
rs866559642 2405 dbSNP
rs553443944 2406 dbSNP
rs946079887 2407 dbSNP
rs773557965 2408 dbSNP
rs541572209 2409 dbSNP
rs1463496085 2411 dbSNP
rs977034202 2419 dbSNP
rs768099193 2423 dbSNP
rs1345528420 2427 dbSNP
rs948482128 2428 dbSNP
rs964286952 2433 dbSNP
rs1437164270 2439 dbSNP
rs1374838965 2449 dbSNP
rs117458905 2450 dbSNP
rs1201750697 2461 dbSNP
rs916999359 2462 dbSNP
rs1192679721 2466 dbSNP
rs1449083165 2468 dbSNP
rs556159074 2470 dbSNP
rs993445172 2471 dbSNP
rs984275009 2474 dbSNP
rs1168858714 2479 dbSNP
rs1396334064 2488 dbSNP
rs148822232 2497 dbSNP
rs1325602240 2499 dbSNP
rs1027424810 2507 dbSNP
rs1467436235 2508 dbSNP
rs1440416120 2516 dbSNP
rs1301464016 2522 dbSNP
rs1367659954 2524 dbSNP
rs1229250700 2533 dbSNP
rs1270564101 2534 dbSNP
rs1338651904 2535 dbSNP
rs1274485428 2536 dbSNP
rs1468500586 2537 dbSNP
rs993626222 2545 dbSNP
rs762034470 2547 dbSNP
rs1250686005 2548 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine PAR-CLIP data was present in GSM796038. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000519824.2 | 3UTR | UCAAGAUCACAUCCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM796038
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000519824.2 | 3UTR | UCAAGAUCACAUCCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-4291 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102445 CALU calumenin 2 4
MIRT108677 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT125969 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT179018 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT379033 CDK6 cyclin dependent kinase 6 2 6
MIRT442473 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 2
MIRT442910 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT442979 ZNF736 zinc finger protein 736 2 2
MIRT445663 TNFSF15 TNF superfamily member 15 2 2
MIRT446237 FZD6 frizzled class receptor 6 2 2
MIRT448860 FAM49B family with sequence similarity 49 member B 2 2
MIRT455559 TRAF1 TNF receptor associated factor 1 2 2
MIRT459704 ZNF641 zinc finger protein 641 2 2
MIRT460608 FEM1A fem-1 homolog A 2 2
MIRT462251 LAMA4 laminin subunit alpha 4 2 2
MIRT462469 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT466656 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 6
MIRT466841 STX6 syntaxin 6 2 2
MIRT471403 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT471517 PCGF3 polycomb group ring finger 3 2 2
MIRT471681 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT472858 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT474813 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT474931 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT475814 HDGF heparin binding growth factor 2 2
MIRT480434 C17orf49 chromosome 17 open reading frame 49 2 2
MIRT480903 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT481478 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484982 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 8
MIRT485019 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 8
MIRT485036 TMEM189 transmembrane protein 189 2 8
MIRT495074 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT496004 CD180 CD180 molecule 2 2
MIRT500675 TRIM37 tripartite motif containing 37 2 2
MIRT504544 ZNF417 zinc finger protein 417 2 6
MIRT506782 KLHL15 kelch like family member 15 2 6
MIRT507256 FGF2 fibroblast growth factor 2 2 6
MIRT507386 EN2 engrailed homeobox 2 2 2
MIRT512505 BTBD19 BTB domain containing 19 2 2
MIRT516903 CTSB cathepsin B 2 2
MIRT528124 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT528874 ATF3 activating transcription factor 3 2 2
MIRT536091 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT541079 RLIM ring finger protein, LIM domain interacting 2 2
MIRT541099 RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2 2
MIRT545360 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545831 ZNF367 zinc finger protein 367 2 4
MIRT547115 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 2
MIRT547312 NPTN neuroplastin 2 2
MIRT547959 HIGD1A HIG1 hypoxia inducible domain family member 1A 2 4
MIRT549943 RPL7L1 ribosomal protein L7 like 1 2 2
MIRT550749 ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2 2
MIRT565145 TUBB2A tubulin beta 2A class IIa 2 2
MIRT571050 POLQ DNA polymerase theta 2 2
MIRT571361 ZNF45 zinc finger protein 45 2 2
MIRT610133 FOXI2 forkhead box I2 2 2
MIRT613145 DSE dermatan sulfate epimerase 2 2
MIRT613379 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT615752 C6 complement C6 2 2
MIRT616460 ADRA2B adrenoceptor alpha 2B 2 2
MIRT616719 FEM1B fem-1 homolog B 2 2
MIRT618312 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT631491 RASSF4 Ras association domain family member 4 2 2
MIRT643134 PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 2 2
MIRT643482 DISC1 disrupted in schizophrenia 1 2 2
MIRT649715 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT653542 SLC38A7 solute carrier family 38 member 7 2 2
MIRT666307 SLC22A3 solute carrier family 22 member 3 2 2
MIRT692005 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT696838 ARL2BP ADP ribosylation factor like GTPase 2 binding protein 2 2
MIRT698204 TMEM248 transmembrane protein 248 2 2
MIRT703316 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT709376 FAM13A family with sequence similarity 13 member A 2 2
MIRT710112 MED23 mediator complex subunit 23 2 2
MIRT711975 HOMER2 homer scaffolding protein 2 2 2
MIRT712275 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT714108 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT719113 MAML1 mastermind like transcriptional coactivator 1 2 2
MIRT719727 SLC39A11 solute carrier family 39 member 11 2 2
MIRT720018 TFAP2C transcription factor AP-2 gamma 2 2
MIRT720358 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT720372 NUDT3 nudix hydrolase 3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4291 Platinum-based doublet chemotherapy resistant High Lung Adenocarcinoma tissue
hsa-miR-4291 Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-4291 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-4291 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-4291 Radioactivity Iodine resistant High Papillary Thyroid Cancer tissue
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-4291 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-4291 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4291 Platinum-based doublet chemotherapy resistant tissue (lung adenocarcinoma)
hsa-miR-4291 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4291 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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