miRTarBase - #MIRT449121


—
pre-miRNA Information
pre-miRNA hsa-mir-2116   
Genomic Coordinates chr15: 59171183 - 59171262
Description Homo sapiens miR-2116 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2116-5p
Sequence 14| GGUUCUUAGCAUAGGAGGUCU |34
Evidence Experimental
Experiments 454
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 - 59171242 29233923 MiREDiBase
A-to-I 13 15 - 59171237 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1217966510 1 dbSNP
rs1170901508 3 dbSNP
rs1364783161 5 dbSNP
rs1240890962 11 dbSNP
rs537360898 13 dbSNP
rs776323490 17 dbSNP
Putative Targets

Gene Information
Gene Symbol XRRA1   
Synonyms -
Description X-ray radiation resistance associated 1
Transcript NM_182969   
Expression
Putative miRNA Targets on XRRA1
3'UTR of XRRA1
(miRNA target sites are highlighted)		 
>XRRA1|NM_182969|3'UTR
   1 AGCTGTGCATGGGGGCTGTGTGCACCACCCGGCCTGTGCCCCAGCTCTCCCCGAGGGCTCTGTGCCCTGGACCGCACCTC
  81 AAGGTTGACCAGCCGGCCACAGGCCTCAGAGCTCAGCTGGGCCCCACTTGCTGGCCACAAGGTGGCATCCCCTTGTCAGG
 161 ATCTCCCCTCCTTGGCCCAGGCATGACCTGGTGCCTGGCCCAGCGGCAATAAAGAGTGGGTGCACAGGGCAATAGACTGG
 241 GTGCCACATGCATTCTTTCTTGGAACCCAGGCCACAGCAGCATTGTCACACTTCCCTCTAAAAATGGTTTTCCAGTTCAG
 321 ATGCAACAGGGATACATTTGTTCTCTGTTGTATGAGAAACTGACACCAAGGGGATCTTAACAAATTCCTGAACAATGGCT
 401 CCAAAAAAGGGTATTTTTAAAAACCAGATCTTGTGAGTACAGCCCTAATGTGCAGGGACAGTGTCATCCTGTATATTCGT
 481 TCTTTACTCAGACTCTTTCTTGGTTCCTTCATTAGGAGCATGAATGGTTGAATGTGAACATGACAGTAAATTGGAGCAAA
 561 CTGTAAACTGGACATAACTTATGCCAAAAGACGTAGTTGTACACCATGGAAACCCCATCCCTGCTCCTAATCTCTACTGC
 641 CATTCTGAATGCCAAAGCAAGACATCCAACATGGGGCATCTCCCAGAGCACATACAGCACCAAAAATCCACACACAGCCT
 721 AAGCTTAACCCATGTTTTTGTCTGAGATTGTTCACCAGAGACAAGACTCTGACTATAAACAGAACATCCACTTTCATGAG
 801 TTTCCTTTACTGTATTCTCAACTTGGGCCTTGCTTCAAGCAGGCAAACATACATTGAAGAATGCACTTTGGTACTGTTTA
 881 AATAACAACACATCAGCCCACTTGATTCCATGCCATGTCCTTGCTGACAGAAACATCCCCAACAGGGCATGCCCTGGTCC
 961 AAGTCCTCTGTCTTTGTCAAAATGCTCTTCTGATGAGTTGGAGAGGAGGCAGCCAGCAGTGGCAGTCCACAAGGATCCAG
1041 GTACCTTCTCCAATCCTAAAGCAGACAGCAGGTTGAATAAAACCAATACACAACCTATTTTCTAGGCAGGAGGGGAAAAG
1121 GCCCTTAGGACAATAATATTTGTACAAAGAGTTGAGAGTAAACAAACAGTGTATCAGGTTCAAAAAAAAAAAAACTATTC
1201 GTTGGCATTTAAATTTTTTTCCCTTGCATAGTATCTATTCTCTCACTAGGACTTTTAAGTGCTCTGCTGGAGGCTCAGCG
1281 TTGGTAATACCATGTTTGATGCAAACTTGAACCCAATGCTCTCATTGGTGGCACAGCTTTGGAGGGTGGTGGCCCCAAGA
1361 AGGGGCAATCTGCCTGCTGCTATATTAATCTGGAACCAGGGCCAACAGCTACTCTTGAACTATGGTATTTGAAGAGCGAG
1441 TTCATTGCCTGTTTTACCTTAAATGACAGGAAAGGAAGATGAACAAACCTTGCTTTGCCTTGGCTTCAAACTAGTTCTTG
1521 ATTTAAGACACCAGAAAGGGAGAGAGGGAGTCTGCTTAGAGTTTGAGGTTGCCTCTCACAAGATGACAGTTAAAAGTTGC
1601 CACCTTACTTAAAAGGCATTAAGGAGGCATTTACTCACAAAGGAGAGAGAGTAAATTTTTTTCTTAAGAGGAAAAAAATA
1681 CTGATAATACATAGAACAATCTGCACATCCAGTCTTGGCACTTTTTCCAATTTGACTGATCTCTAAACTGGTGACCCTTG
1761 CATATATCTTAGTCTCTTTTCTACAATCTTCTTCAGAAAGCTACAGCAGCTAACAATCATGTATAAAGATGCATTTCCTA
1841 GATCATCTTCAGAAGAAAATCTCTTCAGCACTTTCCCTAGAATCTGTCTCCTGACCACCCCGCCCCAGACCTGCTTTCTC
1921 TTTTGAGAATTCATAACCAGGTATGTTTAGATACCAGTTCAAAAGACCACTCTATGGGTTGATGAGGAAAAGGCTGCCTG
2001 AGGACAATTTAAGACCATAATGAGTTTCCAATTTTTAAAGAAAATTTGGCTAGCTGGCTTTTAATTCTTAATTAAAATCA
2081 TTAAATTTAATTAAAATTATTCCAATCAAAATATATCACTTTCCAAGATTCCACATTCATATTACTTACTTATACTATGG
2161 AGACTTTCTCTACCTGAGCATGTATTCAGGGGCTATAGGTACATTTAACTCTAACTAACTGAAAAAAATCAGGAAGAAAA
2241 AACTATTAAAATAAAATAACCTCCTAAATCATTTGGGGGTATCCCCATCAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUGGAGGAUACGAUUCUUGg 5'
            :|:|:|| | :|:||||: 
Target 5' ctGCTTTCTCTTTTGAGAATt 3'
 1911 - 1931 131.00 -10.80
2 
miRNA  3' ucUGGAGGAUACGAUUCU-UGg 5'
            | :||:|:  :||||| || 
Target 5' ctAGTTCTTGATTTAAGACACc 3'
 1511 - 1532 123.00 -10.60
3 
miRNA  3' ucugGAGGAUACGAUUCUUGg 5'
              :||||   :||:||:| 
Target 5' ttggTTCCTTCATTAGGAGCa 3'
 500 - 520 121.00 -13.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30713844 31 COSMIC
COSN28834229 98 COSMIC
COSN31481150 163 COSMIC
COSN20593063 636 COSMIC
COSN21110091 728 COSMIC
COSN28938120 1182 COSMIC
COSN19574923 2079 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1039809600 5 dbSNP
rs1455426327 7 dbSNP
rs1436992164 8 dbSNP
rs761014061 9 dbSNP
rs879924172 10 dbSNP
rs1342335272 13 dbSNP
rs918151436 14 dbSNP
rs1234243331 15 dbSNP
rs374092633 18 dbSNP
rs1348278317 23 dbSNP
rs1201281509 27 dbSNP
rs568147057 28 dbSNP
rs1440519089 29 dbSNP
rs1335546095 30 dbSNP
rs370921187 31 dbSNP
rs1416329644 33 dbSNP
rs774361897 38 dbSNP
rs769179687 39 dbSNP
rs749761321 45 dbSNP
rs554410598 46 dbSNP
rs984410293 49 dbSNP
rs951786291 52 dbSNP
rs1421432177 53 dbSNP
rs968166709 53 dbSNP
rs1274484298 56 dbSNP
rs1332052160 57 dbSNP
rs1020713278 62 dbSNP
rs368040724 63 dbSNP
rs1469610316 71 dbSNP
rs536041721 73 dbSNP
rs971130294 75 dbSNP
rs1024067001 80 dbSNP
rs753624245 84 dbSNP
rs1415691684 85 dbSNP
rs890980460 94 dbSNP
rs1165871696 95 dbSNP
rs517666 98 dbSNP
rs1032910560 101 dbSNP
rs1202077323 109 dbSNP
rs996752018 131 dbSNP
rs1000144931 136 dbSNP
rs796614400 138 dbSNP
rs900498052 144 dbSNP
rs561013497 155 dbSNP
rs942050171 156 dbSNP
rs774980425 159 dbSNP
rs552544930 173 dbSNP
rs1041760204 175 dbSNP
rs998597541 176 dbSNP
rs377764208 184 dbSNP
rs1382959001 187 dbSNP
rs774365919 191 dbSNP
rs959931956 199 dbSNP
rs942849618 203 dbSNP
rs1338266900 204 dbSNP
rs910078347 205 dbSNP
rs1195155034 206 dbSNP
rs1255353765 207 dbSNP
rs1049109738 209 dbSNP
rs930279134 210 dbSNP
rs1420201025 211 dbSNP
rs979476249 213 dbSNP
rs967755896 215 dbSNP
rs766461651 220 dbSNP
rs1386047904 222 dbSNP
rs1402841207 223 dbSNP
rs1020641514 224 dbSNP
rs971721001 226 dbSNP
rs971062853 228 dbSNP
rs1009298874 232 dbSNP
rs374121499 233 dbSNP
rs991259221 248 dbSNP
rs147022369 257 dbSNP
rs370209267 257 dbSNP
rs779783520 257 dbSNP
rs533685158 262 dbSNP
rs1181949636 277 dbSNP
rs1351077320 283 dbSNP
rs1032877702 286 dbSNP
rs759135138 291 dbSNP
rs967281000 294 dbSNP
rs887808612 296 dbSNP
rs1020629209 317 dbSNP
rs998168296 332 dbSNP
rs1259638879 334 dbSNP
rs1205504580 340 dbSNP
rs1436160022 347 dbSNP
rs1181312811 348 dbSNP
rs774000163 354 dbSNP
rs1352652658 356 dbSNP
rs1471308427 361 dbSNP
rs1172131287 365 dbSNP
rs1394925155 371 dbSNP
rs563524831 382 dbSNP
rs866362218 387 dbSNP
rs1315370054 390 dbSNP
rs1403633219 391 dbSNP
rs1389207416 393 dbSNP
rs1327707839 398 dbSNP
rs1238300654 401 dbSNP
rs181780558 403 dbSNP
rs547765580 404 dbSNP
rs896655324 409 dbSNP
rs2298746 411 dbSNP
rs562196451 412 dbSNP
rs748527521 413 dbSNP
rs1381602787 414 dbSNP
rs888609370 433 dbSNP
rs1319316453 435 dbSNP
rs938182346 439 dbSNP
rs1195281961 440 dbSNP
rs541945200 441 dbSNP
rs531371674 442 dbSNP
rs1439772251 444 dbSNP
rs529995381 446 dbSNP
rs1425896341 448 dbSNP
rs189845219 449 dbSNP
rs897373843 458 dbSNP
rs1161759182 459 dbSNP
rs146048972 468 dbSNP
rs553830369 471 dbSNP
rs949680755 474 dbSNP
rs1166772829 476 dbSNP
rs1396669189 479 dbSNP
rs913536876 479 dbSNP
rs769153633 483 dbSNP
rs1369926697 485 dbSNP
rs1373852090 485 dbSNP
rs1195672850 489 dbSNP
rs1303205066 491 dbSNP
rs991228387 491 dbSNP
rs116658745 496 dbSNP
rs556405471 511 dbSNP
rs925696230 516 dbSNP
rs1341578292 517 dbSNP
rs963894248 527 dbSNP
rs186349570 528 dbSNP
rs747529590 530 dbSNP
rs779636306 531 dbSNP
rs1260129924 534 dbSNP
rs1020178198 536 dbSNP
rs1428431214 538 dbSNP
rs114746256 541 dbSNP
rs1243146860 551 dbSNP
rs1005437796 552 dbSNP
rs1373088809 554 dbSNP
rs529352092 556 dbSNP
rs1162287368 562 dbSNP
rs537961865 565 dbSNP
rs1461677464 566 dbSNP
rs1026278280 583 dbSNP
rs1359675731 589 dbSNP
rs965338098 592 dbSNP
rs116023933 593 dbSNP
rs556797642 594 dbSNP
rs1406022048 596 dbSNP
rs888494090 609 dbSNP
rs1368004092 618 dbSNP
rs1272676481 623 dbSNP
rs1056546662 645 dbSNP
rs938198334 646 dbSNP
rs1259275398 665 dbSNP
rs1424079774 671 dbSNP
rs905333278 679 dbSNP
rs1206199228 692 dbSNP
rs1027495461 696 dbSNP
rs994321179 727 dbSNP
rs1185118799 733 dbSNP
rs115654822 735 dbSNP
rs1046628342 737 dbSNP
rs1475323718 738 dbSNP
rs949649777 741 dbSNP
rs895480441 742 dbSNP
rs1055429297 747 dbSNP
rs561865046 757 dbSNP
rs987801538 762 dbSNP
rs777104409 764 dbSNP
rs925697247 765 dbSNP
rs1412897243 768 dbSNP
rs1292741027 770 dbSNP
rs1474567358 771 dbSNP
rs933645469 771 dbSNP
rs978937385 772 dbSNP
rs1371079748 776 dbSNP
rs778604817 787 dbSNP
rs1316654156 794 dbSNP
rs1240181933 795 dbSNP
rs1192684869 800 dbSNP
rs1484976013 802 dbSNP
rs1480684639 803 dbSNP
rs1485714462 811 dbSNP
rs756900976 834 dbSNP
rs945883728 838 dbSNP
rs1270957155 850 dbSNP
rs1220243021 852 dbSNP
rs1405372030 861 dbSNP
rs1450518648 864 dbSNP
rs1418195420 870 dbSNP
rs1273152497 880 dbSNP
rs769014980 882 dbSNP
rs771993336 886 dbSNP
rs1277885087 888 dbSNP
rs1432768139 889 dbSNP
rs763819475 890 dbSNP
rs1224501204 891 dbSNP
rs374346833 892 dbSNP
rs1450329392 901 dbSNP
rs1296577515 906 dbSNP
rs965307518 908 dbSNP
rs547810666 909 dbSNP
rs1018152592 930 dbSNP
rs985396378 937 dbSNP
rs1346185819 940 dbSNP
rs952839082 943 dbSNP
rs755990073 956 dbSNP
rs1281704295 958 dbSNP
rs1312211433 962 dbSNP
rs1336383155 963 dbSNP
rs1211590358 965 dbSNP
rs1331000875 976 dbSNP
rs752639534 976 dbSNP
rs540186261 977 dbSNP
rs1408367816 983 dbSNP
rs994686585 994 dbSNP
rs747584870 1006 dbSNP
rs897312261 1007 dbSNP
rs1239707472 1016 dbSNP
rs1177509243 1022 dbSNP
rs1452378711 1024 dbSNP
rs1470114934 1025 dbSNP
rs1395592262 1030 dbSNP
rs1416143291 1032 dbSNP
rs1025186186 1041 dbSNP
rs1354071633 1042 dbSNP
rs1443130963 1044 dbSNP
rs1333620397 1048 dbSNP
rs767512813 1051 dbSNP
rs1431229873 1053 dbSNP
rs1440657636 1066 dbSNP
rs763012307 1071 dbSNP
rs960675255 1082 dbSNP
rs1477677123 1089 dbSNP
rs895365035 1090 dbSNP
rs1055398268 1091 dbSNP
rs1435635220 1092 dbSNP
rs1257011451 1105 dbSNP
rs1203956371 1106 dbSNP
rs1326061258 1107 dbSNP
rs1466901241 1121 dbSNP
rs1192745570 1123 dbSNP
rs1261693665 1127 dbSNP
rs1002260738 1128 dbSNP
rs1478960993 1133 dbSNP
rs1184724491 1137 dbSNP
rs1219105782 1149 dbSNP
rs905362220 1155 dbSNP
rs1352049156 1167 dbSNP
rs80252847 1168 dbSNP
rs1001177632 1169 dbSNP
rs1011022671 1169 dbSNP
rs9444 1171 dbSNP
rs1326988513 1173 dbSNP
rs181722834 1177 dbSNP
rs1337613112 1181 dbSNP
rs1454821352 1189 dbSNP
rs1218690697 1195 dbSNP
rs1360607712 1195 dbSNP
rs35869416 1195 dbSNP
rs1407979639 1196 dbSNP
rs945822390 1198 dbSNP
rs1212746491 1200 dbSNP
rs1290257114 1201 dbSNP
rs1453119258 1206 dbSNP
rs933675247 1214 dbSNP
rs922242222 1215 dbSNP
rs1478134862 1223 dbSNP
rs779217635 1224 dbSNP
rs531698745 1226 dbSNP
rs1474993303 1227 dbSNP
rs1039866544 1228 dbSNP
rs1413768958 1231 dbSNP
rs776993967 1237 dbSNP
rs942424630 1238 dbSNP
rs1318135448 1239 dbSNP
rs1160284250 1240 dbSNP
rs769144388 1241 dbSNP
rs562297658 1245 dbSNP
rs1353038371 1248 dbSNP
rs911112803 1252 dbSNP
rs951178549 1255 dbSNP
rs1284458935 1262 dbSNP
rs1221835553 1263 dbSNP
rs1462393679 1265 dbSNP
rs985365259 1276 dbSNP
rs141870574 1279 dbSNP
rs919954561 1280 dbSNP
rs1209862780 1284 dbSNP
rs960706260 1288 dbSNP
rs1034989060 1293 dbSNP
rs116089379 1296 dbSNP
rs1485386423 1299 dbSNP
rs961720481 1308 dbSNP
rs560383400 1314 dbSNP
rs575729151 1316 dbSNP
rs1158352264 1321 dbSNP
rs574347613 1324 dbSNP
rs1022788812 1325 dbSNP
rs1311598617 1326 dbSNP
rs1373058244 1327 dbSNP
rs554622275 1328 dbSNP
rs1248391719 1331 dbSNP
rs757024763 1337 dbSNP
rs369280019 1348 dbSNP
rs1341859713 1349 dbSNP
rs892610949 1351 dbSNP
rs375140004 1354 dbSNP
rs1278721010 1363 dbSNP
rs544284678 1368 dbSNP
rs1242145484 1370 dbSNP
rs1278139356 1380 dbSNP
rs1347126023 1382 dbSNP
rs1001554643 1389 dbSNP
rs998357609 1400 dbSNP
rs1436284179 1404 dbSNP
rs1302549988 1415 dbSNP
rs1274082145 1420 dbSNP
rs575406389 1424 dbSNP
rs1446994486 1427 dbSNP
rs776125360 1437 dbSNP
rs562909909 1438 dbSNP
rs1172264693 1443 dbSNP
rs1394981027 1444 dbSNP
rs1043156450 1447 dbSNP
rs1009910432 1457 dbSNP
rs1403792246 1458 dbSNP
rs1407795265 1460 dbSNP
rs1330268527 1464 dbSNP
rs1377307448 1464 dbSNP
rs942350888 1465 dbSNP
rs909659002 1473 dbSNP
rs1398912092 1484 dbSNP
rs143614227 1484 dbSNP
rs1233958856 1485 dbSNP
rs540007414 1488 dbSNP
rs1337537667 1492 dbSNP
rs772755107 1498 dbSNP
rs138745430 1503 dbSNP
rs771460283 1503 dbSNP
rs918391859 1514 dbSNP
rs753552112 1522 dbSNP
rs1459296158 1525 dbSNP
rs1382999850 1529 dbSNP
rs1040788761 1535 dbSNP
rs1252835472 1537 dbSNP
rs1180984451 1538 dbSNP
rs745339901 1542 dbSNP
rs1378791439 1546 dbSNP
rs138166055 1547 dbSNP
rs927195314 1550 dbSNP
rs1214227488 1552 dbSNP
rs911081803 1558 dbSNP
rs1049623925 1568 dbSNP
rs1400536822 1575 dbSNP
rs931262203 1579 dbSNP
rs574556806 1585 dbSNP
rs144812258 1586 dbSNP
rs548381065 1589 dbSNP
rs1224803724 1593 dbSNP
rs1387211483 1606 dbSNP
rs1357443392 1608 dbSNP
rs961413568 1612 dbSNP
rs1218069905 1616 dbSNP
rs1278959838 1630 dbSNP
rs969776609 1631 dbSNP
rs1320262658 1642 dbSNP
rs534237771 1645 dbSNP
rs1212118289 1646 dbSNP
rs917984138 1649 dbSNP
rs568400291 1651 dbSNP
rs1022396675 1652 dbSNP
rs1212108872 1653 dbSNP
rs553113812 1654 dbSNP
rs989494845 1658 dbSNP
rs1428491596 1666 dbSNP
rs1362346707 1667 dbSNP
rs956876122 1668 dbSNP
rs1423794359 1673 dbSNP
rs1162360972 1678 dbSNP
rs1398006134 1679 dbSNP
rs756885489 1679 dbSNP
rs1367635489 1681 dbSNP
rs1458242521 1684 dbSNP
rs534591217 1690 dbSNP
rs1382653343 1698 dbSNP
rs1303757918 1702 dbSNP
rs1298870054 1706 dbSNP
rs959515054 1707 dbSNP
rs1342465917 1709 dbSNP
rs1231607400 1710 dbSNP
rs1312313242 1711 dbSNP
rs548180108 1724 dbSNP
rs537897361 1736 dbSNP
rs754380921 1740 dbSNP
rs1488243176 1741 dbSNP
rs901457986 1750 dbSNP
rs1018926630 1753 dbSNP
rs1489005155 1759 dbSNP
rs1185289873 1760 dbSNP
rs569002314 1764 dbSNP
rs188183255 1772 dbSNP
rs1333263682 1779 dbSNP
rs1166640643 1783 dbSNP
rs1428782552 1784 dbSNP
rs7104291 1786 dbSNP
rs1185161494 1788 dbSNP
rs1477744962 1795 dbSNP
rs1362495330 1803 dbSNP
rs1021216961 1807 dbSNP
rs1270211058 1815 dbSNP
rs1225425517 1820 dbSNP
rs1433904647 1822 dbSNP
rs1305236587 1825 dbSNP
rs1353444062 1839 dbSNP
rs1048182062 1841 dbSNP
rs929674122 1844 dbSNP
rs1207379444 1848 dbSNP
rs777559033 1852 dbSNP
rs1205424314 1858 dbSNP
rs1483363800 1859 dbSNP
rs1183249162 1860 dbSNP
rs896906261 1869 dbSNP
rs891483168 1874 dbSNP
rs938500961 1875 dbSNP
rs1309497324 1876 dbSNP
rs927256259 1880 dbSNP
rs1359831921 1881 dbSNP
rs755902212 1889 dbSNP
rs183592051 1896 dbSNP
rs1007964306 1901 dbSNP
rs1447958918 1902 dbSNP
rs889612033 1902 dbSNP
rs1311973784 1903 dbSNP
rs1369426045 1905 dbSNP
rs1219214494 1907 dbSNP
rs1049986091 1911 dbSNP
rs1312266128 1912 dbSNP
rs915191977 1918 dbSNP
rs1406741222 1930 dbSNP
rs931167244 1937 dbSNP
rs898377505 1944 dbSNP
rs1199006087 1951 dbSNP
rs1292459090 1953 dbSNP
rs989525723 1954 dbSNP
rs956824473 1957 dbSNP
rs1031036499 1960 dbSNP
rs1036969478 1968 dbSNP
rs939998442 1972 dbSNP
rs1435003567 1976 dbSNP
rs1355927483 1978 dbSNP
rs917953035 1979 dbSNP
rs1466401083 1981 dbSNP
rs1333769199 1982 dbSNP
rs767424748 1983 dbSNP
rs1392750948 1988 dbSNP
rs1436299545 1993 dbSNP
rs1275990862 2001 dbSNP
rs1465409921 2015 dbSNP
rs79250122 2031 dbSNP
rs1220432023 2053 dbSNP
rs1275799459 2067 dbSNP
rs529957383 2068 dbSNP
rs938117623 2071 dbSNP
rs1198899903 2079 dbSNP
rs976915203 2081 dbSNP
rs1449686905 2086 dbSNP
rs1220677966 2098 dbSNP
rs1430474399 2100 dbSNP
rs926698361 2103 dbSNP
rs1202171855 2104 dbSNP
rs560822057 2105 dbSNP
rs1018543763 2113 dbSNP
rs1007521726 2115 dbSNP
rs754951970 2119 dbSNP
rs968260823 2139 dbSNP
rs1412020182 2141 dbSNP
rs888122846 2145 dbSNP
rs1352091389 2153 dbSNP
rs1479754625 2153 dbSNP
rs552165067 2155 dbSNP
rs988438323 2162 dbSNP
rs993827371 2165 dbSNP
rs868114584 2170 dbSNP
rs774007160 2174 dbSNP
rs1279723646 2184 dbSNP
rs1177856487 2191 dbSNP
rs1227505316 2192 dbSNP
rs1290417959 2193 dbSNP
rs1323423163 2195 dbSNP
rs955697084 2201 dbSNP
rs896937445 2210 dbSNP
rs1231384236 2211 dbSNP
rs766284460 2213 dbSNP
rs1196047722 2214 dbSNP
rs1317040688 2215 dbSNP
rs1472614460 2217 dbSNP
rs1164192669 2219 dbSNP
rs539882713 2221 dbSNP
rs1044326838 2229 dbSNP
rs1326242480 2229 dbSNP
rs905663120 2229 dbSNP
rs1019277197 2230 dbSNP
rs1310384121 2242 dbSNP
rs1400058425 2243 dbSNP
rs1007849822 2247 dbSNP
rs1299547773 2252 dbSNP
rs755523121 2260 dbSNP
rs889497940 2260 dbSNP
rs1299915237 2261 dbSNP
rs1028086409 2266 dbSNP
rs1284515672 2269 dbSNP
rs1391464308 2270 dbSNP
rs1358203825 2271 dbSNP
rs1237817390 2275 dbSNP
rs1285244978 2276 dbSNP
rs1374939034 2279 dbSNP
rs1354380457 2282 dbSNP
rs1218845531 2290 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000527087.1 | 3UTR | UCAAGAACAUUUUCUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.717 0.03 -0.286 0.27 7 Click to see details
BRCA -0.531 0.09 -0.333 0.21 8 Click to see details
LIHC -0.355 0.11 -0.534 0.02 14 Click to see details
STAD -0.428 0.2 -0.486 0.16 6 Click to see details
HNSC -0.411 0.21 -0.371 0.23 6 Click to see details
UCEC -0.228 0.28 -0.217 0.29 9 Click to see details
KIRP -0.337 0.29 -0.500 0.2 5 Click to see details
KIRC 0.191 0.33 0.119 0.39 8 Click to see details
THCA 0.093 0.38 0.064 0.41 14 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
PAAD 0.375 0.38 -0.500 0.33 3 Click to see details
62 hsa-miR-2116-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080547 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT135054 ADSS adenylosuccinate synthase 2 4
MIRT147317 KPNA2 karyopherin subunit alpha 2 2 4
MIRT154323 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT326799 SYAP1 synapse associated protein 1 2 2
MIRT357963 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384296 GOLT1B golgi transport 1B 2 2
MIRT442316 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443785 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446868 NBPF3 NBPF member 3 2 2
MIRT447647 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448470 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449121 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450245 TRIM66 tripartite motif containing 66 2 2
MIRT450270 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450688 RPN2 ribophorin II 2 2
MIRT481123 AZIN1 antizyme inhibitor 1 2 4
MIRT497207 CDH7 cadherin 7 2 4
MIRT502956 CCNT2 cyclin T2 2 2
MIRT509226 KIF14 kinesin family member 14 2 6
MIRT515395 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525559 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525608 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533254 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535782 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535803 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT543211 TMEM117 transmembrane protein 117 2 2
MIRT552792 YAF2 YY1 associated factor 2 2 2
MIRT553947 STAMBP STAM binding protein 2 2
MIRT556217 MB21D2 Mab-21 domain containing 2 2 2
MIRT566351 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT568429 GDNF glial cell derived neurotrophic factor 2 2
MIRT568521 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT573359 PDE3A phosphodiesterase 3A 2 2
MIRT574653 LMAN2 lectin, mannose binding 2 2 2
MIRT608172 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610692 FAM89A family with sequence similarity 89 member A 2 2
MIRT618459 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT622281 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624615 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631041 TAS2R30 taste 2 receptor member 30 2 2
MIRT638335 RCAN1 regulator of calcineurin 1 2 2
MIRT641630 KIAA1244 ARFGEF family member 3 1 1
MIRT649117 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652246 TPI1 triosephosphate isomerase 1 2 2
MIRT659865 CAPRIN1 cell cycle associated protein 1 2 4
MIRT669219 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682585 CPA4 carboxypeptidase A4 2 2
MIRT690129 EPHX2 epoxide hydrolase 2 2 2
MIRT699793 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT699991 RPS24 ribosomal protein S24 2 2
MIRT710376 LMBR1 limb development membrane protein 1 2 2
MIRT710412 YTHDC1 YTH domain containing 1 2 2
MIRT710574 TNPO1 transportin 1 2 2
MIRT712045 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT713292 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT718211 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718809 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719341 VGLL4 vestigial like family member 4 2 2
MIRT720841 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT724076 NCKAP1L NCK associated protein 1 like 2 2
MIRT724602 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2116 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-2116-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2116-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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