miRTarBase - #MIRT449498


—
pre-miRNA Information
pre-miRNA hsa-mir-4476   
Genomic Coordinates chr9: 36893462 - 36893531
Description Homo sapiens miR-4476 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4476
Sequence 45| CAGGAAGGAUUUAGGGACAGGC |66
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 6 9 - 36893482 29233923 MiREDiBase
A-to-I 9 9 - 36893479 29233923 MiREDiBase
A-to-I 13 9 - 36893475 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs978640498 3 dbSNP
rs1019792440 6 dbSNP
rs1008364367 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZBTB4   
Synonyms KAISO-L1, ZNF903
Description zinc finger and BTB domain containing 4
Transcript NM_001128833   
Other Transcripts NM_020899   
Expression
Putative miRNA Targets on ZBTB4
3'UTR of ZBTB4
(miRNA target sites are highlighted)		 
>ZBTB4|NM_001128833|3'UTR
   1 ACCCTGGGGCTCAATCCCCCTTTCACCAGATGCCACCCTCCCTGAACCCCCCACCACTACCAGCTCCCTGGCCTCCCTGC
  81 CCCTTGGGAGCCCCTTCACACTCTTGTGCAGGGACTTGGGGGCCCCTGGAGCTCAGGGGTCAGGCTGCTTTGTGTGAGAT
 161 GTAGTTTTCCCATCTCCTGGGAAGGGATCTTTCGAGGTTCCCCTCTCAGTCTTCCTCCAGGGAATGGCCTCCATGAGGGG
 241 CAGGGCCAGCTTCCATCCCTTCTCCAGCCCTTGGGGCAACTGAGCAATATACTTAACCTGAATCTCTACTCACAGCCCCC
 321 ACCAGCTCTGAATGTCTAACCTGCTCCCCTGATTCGTAAACCTAGGGGAAACCATCTCTCTCACCTAATGACCCGCCTTG
 401 TTCTGAAGCTTTCTCTAAGCCCTTCCCAGTTGCTTCCTAGCACATTCCATTCTTTGTGGCCCAGGGCCTGGACCAGACCA
 481 TTGTGATACCTGACCCCGCCCACCTGGGAGTGTGGCTTTGGGTTTCATCCTTCCCCAGCGTGGGTCTCTACGTCCCTGTT
 561 TCCCTTGTATCAAGACACCTTCCTCAGCTTCCATGCCTTTGGATCTTCCATGTTCCTCCCCATATTCCTGGACTTCGGAG
 641 ATGGCCTCTCCCAAGCCAGGTCAAGGAGGTTTGGGGGAGGGTTGCCCCTCTGCCCCTCTGTTCTGTGGCTGAGCACTTTC
 721 CCAGTCCAGGGCAGGGAAATATTGGCCCTATCTTGACCCCCAAATCCAGTGAGCTCCAGATTCTTCCAAGGCAAAAGAGG
 801 TAAGCAGATCACACCTCTTTCTGCCTCTACATATGGCCTATTCTGGGCTAGACCAGATTTGGGGGCCAGGAGGGAAGAAC
 881 TCCATATGGGATGGAGAAGGGAATCTACTTTCTCCCTGTTTTTTTTTCCTGATGGTTTCTCCCAGACTAGACCAAATAGC
 961 CAGAAAAATGATAGGGGTCGGATGGGTGGGTAAGCCCAGGATTTGCACATGACCTTCCATCCTTACCTGTATTCCCATCT
1041 CCCCAGTGTCACTCCCCTCACCAATCACTCCAGATGGTTTTGGGGGAACCATTCTACTCTTCTGGTGGGCTTTGGGGTAT
1121 CCCCACCAACTTTCCCTTCAAAATAGCACCTTACACCCCATCTTTGACTCAGTTCCCCACACCCAAAGATCCCAGCCTAG
1201 GGATGGGGTACAGGGACTTTAAATAGTCCCTAATCCCTAATTTGCACTAGTTAACCCTGGTCAGGGTCCCTGTATTTCCT
1281 TCCAGTGGGGGAGATAAATGTTTGCTCCTAATTCTCTTTGAAAACTGGGCCTCCCTGCTCTGTGATTGGATAAATATTTC
1361 CCATCCCACCCACCTCCCCCCAAAAAATAGCTCACAAGGGGAGAGCCAGTATGGGGGAGCAAATTTGACAAATGGGAATT
1441 AGAGGAGTGCAGTTTTAAAAGGAAAAGTTGCTGTCATCAAAATGGCAGCCTTTTCCCCAGCTACTGTTTTTGGGGCCAAG
1521 ATGGCTGCCCTAGCAGCAATCACTGCCAAGGGCAAGATCATGGCTTTTGGAGGGAGGTGAGTTTAGGGAGGGCCAGGACC
1601 ATCCTCCTACCCCTCATACCCTCCCAGCATATACAAAAGGGGAGGTTTTAGACAGGCTCCCTGAATGTTAACCACAGAGG
1681 AGTCACTCCTTCATTCCTCCTCTGTCTCTTTGCACTTTTCTTGGTCTTGGCCACAGCCTGAGTGACGAATTTCCTACTGA
1761 ATGTACCAAGTTCCAATTTTTAAGGGGGGGAAAGGTTTCAAATGGGGAAAAACACACAAAAAAAAAATCACTAAAAATTC
1841 CCACAAATCTTGTTTCTGGCACTTTAGAAAAACTGCAAAAAAATACGTAATAAAGAATACATATATATATATCTACACAC
1921 AAATTATATATCTATCTATCTATACAGCGGAACCACAAGAGAGACTGAGGAAGGCCTGGAGGCAGGGGCAGAGGTGACGA
2001 CAGTGCCCCTATATCCTTAACCCATACTCCTCTGAGGCAAACAGGCATGGGAAAATGGAAGGGTTGAGGATGGACCGGAG
2081 AATTGGAACTTCAGAATAGGTCAAAATTCCAAAACCATGGACATTTTTTTTTGGGAGAATTGAGATTGTAGACATTTTTT
2161 TTTTCTTAAATATGATCAAGGAAAATAGCTTCCAGAATGTGGTGGTTCTGGGCAACAAATGAGATTGTGGCGACGTGGAG
2241 ATTAAAATATATGTATTTGAGCTGGGGAATTTGAATATTGTGAGTTTCAGATGTTGGAAATTTGGGATTTTGCAGTTTTG
2321 TCTTTTGAAAATGATCAAGTCTTGTCAGTTCGTGCCCTCTTTCCCCATGTTCCCTGGGAAGACGGGTGGTGGCAGAGTGA
2401 GAAGGCCACTGGTTCTGTGCCGCAGCACGCAAAATTTAGAATTCTACAGACTAGCTCTATACGTAGTGAGGACCCAGATT
2481 TAGAGAAACTGACCAATATTTATCTCCGCATTTGTGTGTGTGTCCAACTCTGTAGGCCAATAAACCAACAAGACAAATGA
2561 ACTGTGCTCCACAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGACAGGGAUUUAGGAAGGac 5'
            || ||:||||: ||||||  
Target 5' agCTTTCTCTAAGCCCTTCCca 3'
 407 - 428 156.00 -21.30
2 
miRNA  3' cgGACAGGGAUUU-AGGAAGGAc 5'
            :||| :| |:|  ||||||| 
Target 5' ccTTGTATCAAGACACCTTCCTc 3'
 563 - 585 156.00 -14.60
3 
miRNA  3' cggaCAGGGAUUU--AGGAAGGac 5'
              ||||||: |  |||||||  
Target 5' caggGTCCCTGTATTTCCTTCCag 3'
 1262 - 1285 148.00 -22.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30483518 36 COSMIC
COSN25338950 42 COSMIC
COSN30647397 47 COSMIC
COSN27005503 58 COSMIC
COSN30543528 64 COSMIC
COSN30474787 67 COSMIC
COSN30522279 88 COSMIC
COSN31482886 97 COSMIC
COSN30456124 126 COSMIC
COSN31610716 161 COSMIC
COSN7455486 185 COSMIC
COSN30117657 194 COSMIC
COSN31564926 452 COSMIC
COSN30541446 457 COSMIC
COSN22579379 485 COSMIC
COSN26639745 530 COSMIC
COSN31517518 636 COSMIC
COSN26565797 685 COSMIC
COSN31482019 760 COSMIC
COSN15878524 780 COSMIC
COSN19655922 801 COSMIC
COSN31528603 803 COSMIC
COSN30541263 838 COSMIC
COSN31600960 877 COSMIC
COSN31555230 918 COSMIC
COSN31550142 1057 COSMIC
COSN26586154 1211 COSMIC
COSN31583953 1213 COSMIC
COSN31485030 1546 COSMIC
COSN31531390 1590 COSMIC
COSN31482007 1659 COSMIC
COSN31485874 1746 COSMIC
COSN31481960 1753 COSMIC
COSN31567498 1778 COSMIC
COSN19250792 1789 COSMIC
COSN23839648 1817 COSMIC
COSN20113458 1818 COSMIC
COSN26644745 1819 COSMIC
COSN1728988 1837 COSMIC
COSN31481938 1857 COSMIC
COSN31573043 1901 COSMIC
COSN31543863 1908 COSMIC
COSN31597154 1999 COSMIC
COSN17935242 2078 COSMIC
COSN17638504 2133 COSMIC
COSN23486634 2155 COSMIC
COSN27575179 2155 COSMIC
COSN21400242 2178 COSMIC
COSN9673942 2183 COSMIC
COSN30541252 2407 COSMIC
COSN31537675 2544 COSMIC
COSN31515772 2552 COSMIC
rs9217 2171 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1198301452 2 dbSNP
rs373429072 8 dbSNP
rs745811486 9 dbSNP
rs1177348826 19 dbSNP
rs538086275 21 dbSNP
rs1375877735 25 dbSNP
rs1447324395 29 dbSNP
rs781443119 37 dbSNP
rs755152252 44 dbSNP
rs751662865 46 dbSNP
rs199829683 48 dbSNP
rs753782481 49 dbSNP
rs1010533666 55 dbSNP
rs893358957 59 dbSNP
rs1212084044 60 dbSNP
rs1055989816 61 dbSNP
rs1271586644 75 dbSNP
rs549131771 76 dbSNP
rs928846593 83 dbSNP
rs1179700348 87 dbSNP
rs527396846 95 dbSNP
rs369963786 116 dbSNP
rs1205151715 121 dbSNP
rs1187128372 123 dbSNP
rs868424522 124 dbSNP
rs1459574897 130 dbSNP
rs1166080083 131 dbSNP
rs376962489 134 dbSNP
rs1399519153 137 dbSNP
rs1465914571 141 dbSNP
rs1333069547 155 dbSNP
rs1380333251 162 dbSNP
rs566530732 169 dbSNP
rs1312990224 170 dbSNP
rs1341737034 171 dbSNP
rs551090106 176 dbSNP
rs1222000134 185 dbSNP
rs747575740 193 dbSNP
rs778652678 193 dbSNP
rs918683543 194 dbSNP
rs974041022 195 dbSNP
rs1199850596 208 dbSNP
rs1317802147 208 dbSNP
rs1260332287 217 dbSNP
rs1047338819 222 dbSNP
rs111848741 224 dbSNP
rs1200091172 228 dbSNP
rs1257203009 233 dbSNP
rs111690305 235 dbSNP
rs1423042035 237 dbSNP
rs911125811 262 dbSNP
rs1403542866 279 dbSNP
rs1465416749 283 dbSNP
rs1303052937 287 dbSNP
rs1403957447 292 dbSNP
rs1055900371 293 dbSNP
rs1296989388 297 dbSNP
rs182435232 309 dbSNP
rs1219716409 310 dbSNP
rs985425126 318 dbSNP
rs955378204 322 dbSNP
rs1334972594 325 dbSNP
rs1280724978 329 dbSNP
rs1310799011 331 dbSNP
rs937733898 333 dbSNP
rs926416123 335 dbSNP
rs1421463317 340 dbSNP
rs1029538805 346 dbSNP
rs1484334234 347 dbSNP
rs1475071696 351 dbSNP
rs946442908 353 dbSNP
rs1388273987 354 dbSNP
rs778942402 355 dbSNP
rs115990086 356 dbSNP
rs1022011725 361 dbSNP
rs1379177352 363 dbSNP
rs1010502497 366 dbSNP
rs531815301 378 dbSNP
rs1451105566 383 dbSNP
rs561163601 387 dbSNP
rs955288407 388 dbSNP
rs542786569 390 dbSNP
rs539397385 395 dbSNP
rs374077424 403 dbSNP
rs749424277 413 dbSNP
rs1366170594 418 dbSNP
rs1386734300 420 dbSNP
rs975298478 421 dbSNP
rs777691704 423 dbSNP
rs964464665 434 dbSNP
rs1017055623 441 dbSNP
rs1005961567 455 dbSNP
rs951342593 468 dbSNP
rs1001827171 475 dbSNP
rs1488089112 480 dbSNP
rs1191717452 487 dbSNP
rs146199517 491 dbSNP
rs1337959192 492 dbSNP
rs1045865807 494 dbSNP
rs1437668640 494 dbSNP
rs930149683 495 dbSNP
rs1246716543 496 dbSNP
rs896089235 497 dbSNP
rs1161084560 498 dbSNP
rs918651006 498 dbSNP
rs1457791046 500 dbSNP
rs572373055 508 dbSNP
rs752796104 514 dbSNP
rs545116626 517 dbSNP
rs1313171963 521 dbSNP
rs911261628 531 dbSNP
rs781549719 540 dbSNP
rs1445102559 546 dbSNP
rs1444719259 551 dbSNP
rs1242615137 552 dbSNP
rs985780340 559 dbSNP
rs1287745829 572 dbSNP
rs1321204298 574 dbSNP
rs1222216074 578 dbSNP
rs1267212047 582 dbSNP
rs1001738973 585 dbSNP
rs933885054 587 dbSNP
rs1356040391 588 dbSNP
rs755289151 591 dbSNP
rs1238598491 602 dbSNP
rs1441101165 604 dbSNP
rs977921146 608 dbSNP
rs904938637 610 dbSNP
rs1423953320 612 dbSNP
rs1166088122 622 dbSNP
rs1043443420 631 dbSNP
rs946456400 633 dbSNP
rs1368561351 637 dbSNP
rs1401500094 644 dbSNP
rs1449192274 645 dbSNP
rs752093800 646 dbSNP
rs762662408 655 dbSNP
rs1229015538 656 dbSNP
rs1314739368 664 dbSNP
rs1315948510 669 dbSNP
rs577970529 674 dbSNP
rs1197954436 688 dbSNP
rs1258398911 688 dbSNP
rs1021981213 693 dbSNP
rs1052117490 696 dbSNP
rs1444707931 697 dbSNP
rs1472827288 704 dbSNP
rs1384143874 710 dbSNP
rs933875659 723 dbSNP
rs1477095006 729 dbSNP
rs556526679 732 dbSNP
rs1170600664 738 dbSNP
rs989217868 741 dbSNP
rs1179714034 742 dbSNP
rs1424782780 742 dbSNP
rs1332412357 750 dbSNP
rs959023097 755 dbSNP
rs141653568 757 dbSNP
rs1449076587 760 dbSNP
rs1003629889 762 dbSNP
rs975642380 762 dbSNP
rs1204213860 765 dbSNP
rs963953622 768 dbSNP
rs138647816 790 dbSNP
rs1278838034 805 dbSNP
rs1319717965 806 dbSNP
rs1217311443 813 dbSNP
rs1277439670 815 dbSNP
rs1294511600 816 dbSNP
rs555620588 823 dbSNP
rs1223960454 826 dbSNP
rs1358814738 827 dbSNP
rs1260324595 831 dbSNP
rs1487715438 833 dbSNP
rs984189591 840 dbSNP
rs1264594100 849 dbSNP
rs554150266 852 dbSNP
rs907424288 868 dbSNP
rs1424937658 872 dbSNP
rs1415194347 880 dbSNP
rs951480709 882 dbSNP
rs1374276059 884 dbSNP
rs535371807 885 dbSNP
rs533938347 897 dbSNP
rs1025577409 905 dbSNP
rs1279191983 907 dbSNP
rs1441133976 908 dbSNP
rs1348459717 916 dbSNP
rs1304869550 918 dbSNP
rs1425261790 919 dbSNP
rs1273978052 923 dbSNP
rs1014233482 928 dbSNP
rs1266546100 928 dbSNP
rs1283513143 933 dbSNP
rs568274730 945 dbSNP
rs994319863 949 dbSNP
rs1264746742 958 dbSNP
rs1449192181 959 dbSNP
rs1197392941 963 dbSNP
rs1478597400 969 dbSNP
rs897358815 972 dbSNP
rs1378749855 974 dbSNP
rs566451954 979 dbSNP
rs1043628629 980 dbSNP
rs3177511 982 dbSNP
rs1176283509 999 dbSNP
rs1403479374 1000 dbSNP
rs941466619 1016 dbSNP
rs551446240 1020 dbSNP
rs1010636038 1024 dbSNP
rs889878948 1028 dbSNP
rs749218096 1035 dbSNP
rs933997047 1041 dbSNP
rs1240446374 1043 dbSNP
rs922518143 1046 dbSNP
rs978435582 1066 dbSNP
rs539108552 1070 dbSNP
rs1353655178 1087 dbSNP
rs775129983 1087 dbSNP
rs1208578525 1091 dbSNP
rs915109490 1092 dbSNP
rs1289869521 1114 dbSNP
rs989186535 1122 dbSNP
rs1215989171 1125 dbSNP
rs1452531753 1125 dbSNP
rs568812016 1130 dbSNP
rs1439265095 1134 dbSNP
rs1033860744 1143 dbSNP
rs1217957155 1144 dbSNP
rs981777655 1154 dbSNP
rs1283807079 1168 dbSNP
rs550094538 1175 dbSNP
rs909689905 1176 dbSNP
rs1326773439 1180 dbSNP
rs930044461 1188 dbSNP
rs1024548196 1189 dbSNP
rs1446974540 1190 dbSNP
rs994457766 1195 dbSNP
rs918700486 1197 dbSNP
rs992780914 1199 dbSNP
rs897328041 1211 dbSNP
rs1336057949 1212 dbSNP
rs769125760 1228 dbSNP
rs1291724010 1229 dbSNP
rs1432218436 1245 dbSNP
rs1256496887 1249 dbSNP
rs1345329453 1253 dbSNP
rs1199493691 1265 dbSNP
rs1034771625 1269 dbSNP
rs75312798 1270 dbSNP
rs74820808 1271 dbSNP
rs980350340 1274 dbSNP
rs1017075965 1290 dbSNP
rs1005733445 1300 dbSNP
rs549682240 1305 dbSNP
rs1369148119 1306 dbSNP
rs1476111682 1311 dbSNP
rs1168445853 1316 dbSNP
rs1422656307 1318 dbSNP
rs1466003689 1330 dbSNP
rs531904690 1335 dbSNP
rs1399667993 1336 dbSNP
rs538354436 1345 dbSNP
rs763349708 1346 dbSNP
rs1431005212 1349 dbSNP
rs1334192816 1354 dbSNP
rs1177551888 1359 dbSNP
rs1480316287 1361 dbSNP
rs1010436538 1368 dbSNP
rs143120070 1369 dbSNP
rs1317657042 1376 dbSNP
rs1030793965 1379 dbSNP
rs997940424 1380 dbSNP
rs1188858169 1381 dbSNP
rs1256868542 1382 dbSNP
rs1486230965 1382 dbSNP
rs998176406 1385 dbSNP
rs759107032 1388 dbSNP
rs1241633102 1390 dbSNP
rs1486730959 1409 dbSNP
rs1191408327 1413 dbSNP
rs1207029555 1414 dbSNP
rs1462789296 1416 dbSNP
rs900805636 1420 dbSNP
rs191122288 1425 dbSNP
rs866994414 1447 dbSNP
rs1223828673 1449 dbSNP
rs1465183217 1456 dbSNP
rs942610903 1462 dbSNP
rs1376739993 1470 dbSNP
rs1299090090 1472 dbSNP
rs1216328121 1477 dbSNP
rs888386831 1489 dbSNP
rs1340408077 1491 dbSNP
rs1362001366 1500 dbSNP
rs1287833304 1501 dbSNP
rs779433009 1506 dbSNP
rs945333682 1536 dbSNP
rs1298105743 1541 dbSNP
rs878911502 1558 dbSNP
rs1048203108 1560 dbSNP
rs763511314 1561 dbSNP
rs545724605 1574 dbSNP
rs1407756631 1576 dbSNP
rs1336996980 1577 dbSNP
rs186268476 1581 dbSNP
rs937865441 1600 dbSNP
rs1376350263 1613 dbSNP
rs926374870 1623 dbSNP
rs1486127037 1625 dbSNP
rs760376257 1628 dbSNP
rs1264922578 1633 dbSNP
rs560430262 1636 dbSNP
rs35293352 1643 dbSNP
rs1429676175 1644 dbSNP
rs1199105127 1649 dbSNP
rs149094559 1657 dbSNP
rs938778377 1665 dbSNP
rs1360619933 1672 dbSNP
rs1291210386 1673 dbSNP
rs1365907642 1675 dbSNP
rs971728223 1676 dbSNP
rs1304406013 1678 dbSNP
rs980532323 1680 dbSNP
rs961588873 1682 dbSNP
rs1308553286 1699 dbSNP
rs1022326728 1704 dbSNP
rs1217860296 1710 dbSNP
rs1203341982 1711 dbSNP
rs1488017054 1718 dbSNP
rs1214047961 1727 dbSNP
rs1254677919 1728 dbSNP
rs1437370323 1733 dbSNP
rs988973640 1735 dbSNP
rs1204656798 1739 dbSNP
rs577987066 1740 dbSNP
rs1017208928 1746 dbSNP
rs1161891528 1746 dbSNP
rs867721165 1747 dbSNP
rs1326942483 1764 dbSNP
rs954377298 1770 dbSNP
rs1206510988 1776 dbSNP
rs997909175 1778 dbSNP
rs1028392531 1782 dbSNP
rs1307964825 1782 dbSNP
rs34055023 1785 dbSNP
rs901171639 1787 dbSNP
rs1042328910 1788 dbSNP
rs1225470782 1791 dbSNP
rs544587458 1792 dbSNP
rs1384432698 1793 dbSNP
rs8081449 1794 dbSNP
rs1006997953 1803 dbSNP
rs555657293 1804 dbSNP
rs1395129286 1813 dbSNP
rs34779616 1813 dbSNP
rs1400483578 1815 dbSNP
rs1300209060 1817 dbSNP
rs1462846716 1818 dbSNP
rs10729 1819 dbSNP
rs879048676 1819 dbSNP
rs1456325340 1821 dbSNP
rs1197603079 1823 dbSNP
rs201431888 1828 dbSNP
rs1412475468 1829 dbSNP
rs1481312562 1829 dbSNP
rs34579688 1829 dbSNP
rs371036148 1829 dbSNP
rs397732975 1829 dbSNP
rs398078866 1829 dbSNP
rs532290650 1829 dbSNP
rs565204151 1829 dbSNP
rs1231122638 1834 dbSNP
rs1475135743 1841 dbSNP
rs1166292171 1850 dbSNP
rs879190893 1854 dbSNP
rs1420470072 1856 dbSNP
rs1053654912 1869 dbSNP
rs1464445773 1873 dbSNP
rs1330908319 1875 dbSNP
rs1354398568 1885 dbSNP
rs1355294100 1885 dbSNP
rs550394903 1885 dbSNP
rs926484649 1887 dbSNP
rs994052895 1888 dbSNP
rs540028615 1899 dbSNP
rs1386014581 1900 dbSNP
rs1046146399 1904 dbSNP
rs774256345 1906 dbSNP
rs572991325 1908 dbSNP
rs971697241 1910 dbSNP
rs1044393346 1912 dbSNP
rs1189253213 1914 dbSNP
rs746775254 1914 dbSNP
rs963056565 1914 dbSNP
rs1411801131 1920 dbSNP
rs989030758 1923 dbSNP
rs1273808474 1925 dbSNP
rs956290965 1928 dbSNP
rs923412353 1929 dbSNP
rs910115201 1933 dbSNP
rs557594553 1935 dbSNP
rs181554683 1943 dbSNP
rs965145395 1945 dbSNP
rs976272561 1945 dbSNP
rs1217113885 1948 dbSNP
rs984399090 1949 dbSNP
rs188907364 1950 dbSNP
rs1028948098 1954 dbSNP
rs998366142 1955 dbSNP
rs1283287544 1963 dbSNP
rs1487561293 1964 dbSNP
rs1291928083 1978 dbSNP
rs1243050616 1998 dbSNP
rs550165878 1999 dbSNP
rs965807886 2000 dbSNP
rs770949136 2002 dbSNP
rs1338291520 2003 dbSNP
rs1394744052 2007 dbSNP
rs1021014479 2010 dbSNP
rs1435610563 2012 dbSNP
rs186060676 2015 dbSNP
rs1009506519 2020 dbSNP
rs1358719328 2023 dbSNP
rs577956250 2030 dbSNP
rs1318978274 2031 dbSNP
rs1346734571 2038 dbSNP
rs893836990 2046 dbSNP
rs1392274294 2047 dbSNP
rs1371213622 2050 dbSNP
rs1032213009 2077 dbSNP
rs1306715390 2078 dbSNP
rs1002572366 2081 dbSNP
rs1205043417 2089 dbSNP
rs1285631874 2100 dbSNP
rs181567261 2105 dbSNP
rs905114110 2117 dbSNP
rs549650609 2124 dbSNP
rs1162689501 2125 dbSNP
rs1046624052 2133 dbSNP
rs1003151667 2134 dbSNP
rs572999573 2134 dbSNP
rs1159055254 2136 dbSNP
rs1410124845 2148 dbSNP
rs527911297 2150 dbSNP
rs12453572 2151 dbSNP
rs1394946758 2156 dbSNP
rs1036135659 2158 dbSNP
rs1442641861 2161 dbSNP
rs941661235 2165 dbSNP
rs1280813469 2166 dbSNP
rs1320422660 2166 dbSNP
rs914550866 2166 dbSNP
rs1365697053 2169 dbSNP
rs9217 2171 dbSNP
rs773407368 2181 dbSNP
rs923548020 2184 dbSNP
rs533486632 2190 dbSNP
rs1215776404 2196 dbSNP
rs1179894440 2199 dbSNP
rs932857011 2200 dbSNP
rs1236632779 2202 dbSNP
rs371972614 2204 dbSNP
rs1182572598 2211 dbSNP
rs1208662398 2212 dbSNP
rs976270128 2213 dbSNP
rs977295707 2232 dbSNP
rs748393027 2233 dbSNP
rs1168052115 2235 dbSNP
rs1262111866 2236 dbSNP
rs189182868 2246 dbSNP
rs1391632744 2252 dbSNP
rs529294062 2256 dbSNP
rs1338200273 2266 dbSNP
rs1413473234 2267 dbSNP
rs562009083 2269 dbSNP
rs781353534 2276 dbSNP
rs965286628 2278 dbSNP
rs1239408135 2279 dbSNP
rs910724699 2281 dbSNP
rs1250010488 2282 dbSNP
rs1338928822 2284 dbSNP
rs1196605420 2286 dbSNP
rs772416355 2291 dbSNP
rs1252747033 2302 dbSNP
rs1440826733 2303 dbSNP
rs1187109769 2316 dbSNP
rs988220752 2325 dbSNP
rs1258180196 2326 dbSNP
rs1328875486 2335 dbSNP
rs1286900438 2336 dbSNP
rs985584218 2350 dbSNP
rs1372299613 2351 dbSNP
rs1348946919 2352 dbSNP
rs952482246 2353 dbSNP
rs958030455 2355 dbSNP
rs1399420973 2356 dbSNP
rs1433614534 2362 dbSNP
rs1312773635 2364 dbSNP
rs1356619599 2368 dbSNP
rs1417187000 2369 dbSNP
rs1293795371 2370 dbSNP
rs1032266992 2384 dbSNP
rs1228411532 2385 dbSNP
rs1253350498 2392 dbSNP
rs75345110 2393 dbSNP
rs1210195642 2398 dbSNP
rs755164520 2410 dbSNP
rs1047300 2416 dbSNP
rs961267766 2422 dbSNP
rs905082560 2423 dbSNP
rs1159334148 2424 dbSNP
rs1375615504 2429 dbSNP
rs1035608612 2430 dbSNP
rs1173665520 2453 dbSNP
rs747426046 2458 dbSNP
rs1437118286 2460 dbSNP
rs1410058851 2463 dbSNP
rs1156629129 2464 dbSNP
rs1383166383 2480 dbSNP
rs1298223980 2490 dbSNP
rs1368984628 2497 dbSNP
rs1233860068 2505 dbSNP
rs753161493 2509 dbSNP
rs572986028 2515 dbSNP
rs1213546728 2525 dbSNP
rs1260126139 2525 dbSNP
rs905656578 2534 dbSNP
rs1022812244 2557 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions BC-1
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM796037. RNA binding protein: AGO2. Condition:4-Thiouridine ...

- Gottwein E; Corcoran DL; Mukherjee N; et al., 2011, Cell host & microbe.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggacagGGAUUU-AGGAAGGAc 5'
                 :| |:|  ||||||| 
Target 5' -------UCAAGACACCUUCCUc 3'
 		1 - 16
Article - Gottwein E; Corcoran DL; Mukherjee N; et al.
- Cell host & microbe, 2011
Primary effusion lymphoma (PEL) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and frequently also harbors Epstein-Barr virus (EBV). The expression of KSHV- and EBV-encoded microRNAs (miRNAs) in PELs suggests a role for these miRNAs in latency and lymphomagenesis. Using PAR-CLIP, a technology which allows the direct and transcriptome-wide identification of miRNA targets, we delineate the target sites for all viral and cellular miRNAs expressed in PEL cell lines. The resulting data set revealed that KSHV miRNAs directly target more than 2000 cellular mRNAs, including many involved in pathways relevant to KSHV pathogenesis. Moreover, 58% of these mRNAs are also targeted by EBV miRNAs, via distinct binding sites. In addition to a known viral analog of cellular miR-155, we show that KSHV encodes a viral miRNA that mimics cellular miR-142-3p function. In summary, this study identifies an extensive list of KSHV miRNA targets, which are likely to influence viral replication and pathogenesis.
LinkOut: [PMID: 22100165]
CLIP-seq Support 1 for dataset GSM796037
Method / RBP PAR-CLIP / AGO2
Cell line / Condition BC-1 / 4-Thiouridine
Location of target site ENST00000380599.4 | 3UTR | UCAAGACACCUUCCUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22100165 / GSE32109
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
152 hsa-miR-4476 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT065631 CLIC4 chloride intracellular channel 4 2 2
MIRT076187 GID4 GID complex subunit 4 homolog 2 4
MIRT086304 HOXD8 homeobox D8 2 6
MIRT110644 ARID5B AT-rich interaction domain 5B 2 2
MIRT144337 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT196634 TAOK1 TAO kinase 1 2 6
MIRT227655 SET SET nuclear proto-oncogene 2 2
MIRT263546 PPIF peptidylprolyl isomerase F 2 4
MIRT266189 TXNIP thioredoxin interacting protein 2 4
MIRT266815 SLC25A44 solute carrier family 25 member 44 2 2
MIRT285538 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT295094 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT300906 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT304110 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 6
MIRT314891 RGMB repulsive guidance molecule family member b 2 2
MIRT364225 ANP32B acidic nuclear phosphoprotein 32 family member B 2 2
MIRT366237 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405440 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT443613 OR2D2 olfactory receptor family 2 subfamily D member 2 2 2
MIRT445947 SCML4 Scm polycomb group protein like 4 2 2
MIRT445957 MLLT11 MLLT11, transcription factor 7 cofactor 2 2
MIRT445970 IKZF5 IKAROS family zinc finger 5 2 2
MIRT448066 MMP15 matrix metallopeptidase 15 2 2
MIRT449498 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT450831 IFFO1 intermediate filament family orphan 1 2 2
MIRT451270 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT451318 LGALS3BP galectin 3 binding protein 2 2
MIRT451403 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT451941 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452028 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452503 HMGXB3 HMG-box containing 3 2 2
MIRT453852 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454523 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT455402 PLA2G2F phospholipase A2 group IIF 2 2
MIRT455442 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT456983 MANEA mannosidase endo-alpha 2 2
MIRT457610 IDS iduronate 2-sulfatase 2 2
MIRT458319 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458756 CES2 carboxylesterase 2 2 2
MIRT458960 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460403 GPHA2 glycoprotein hormone alpha 2 2 2
MIRT460632 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461760 DDX11 DEAD/H-box helicase 11 2 2
MIRT461924 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT461977 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462271 TPI1 triosephosphate isomerase 1 2 2
MIRT462304 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT462725 SEMA4G semaphorin 4G 2 2
MIRT463414 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463525 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT464089 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464623 UBE4B ubiquitination factor E4B 2 2
MIRT465030 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465562 TOB2 transducer of ERBB2, 2 2 2
MIRT465890 TMEM43 transmembrane protein 43 2 2
MIRT466428 TFAP2A transcription factor AP-2 alpha 2 8
MIRT466593 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467623 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468511 SESN2 sestrin 2 2 2
MIRT468649 SEH1L SEH1 like nucleoporin 2 2
MIRT468737 SDC4 syndecan 4 2 2
MIRT468752 SDC2 syndecan 2 2 2
MIRT469182 RNF111 ring finger protein 111 2 2
MIRT469476 REEP5 receptor accessory protein 5 2 2
MIRT472078 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT472093 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT472194 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT472453 NAV2 neuron navigator 2 2 6
MIRT474493 KLHDC8B kelch domain containing 8B 2 2
MIRT475174 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475350 IFNLR1 interferon lambda receptor 1 2 2
MIRT476474 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477094 FAM168A family with sequence similarity 168 member A 2 2
MIRT477179 F3 coagulation factor III, tissue factor 2 6
MIRT478026 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT479587 CDC42SE1 CDC42 small effector 1 2 2
MIRT480117 CALR calreticulin 2 2
MIRT480465 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT480803 BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 2 6
MIRT481076 B4GALT1 beta-1,4-galactosyltransferase 1 2 2
MIRT482576 ABHD2 abhydrolase domain containing 2 2 2
MIRT482690 NXN nucleoredoxin 2 4
MIRT483599 SLC26A9 solute carrier family 26 member 9 2 2
MIRT485011 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT488051 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488067 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488176 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488859 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489074 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT489181 ANKRD45 ankyrin repeat domain 45 2 2
MIRT489981 DDB1 damage specific DNA binding protein 1 2 2
MIRT490225 WRN Werner syndrome RecQ like helicase 2 2
MIRT491084 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT491540 HDAC5 histone deacetylase 5 2 2
MIRT492540 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT499034 MAG myelin associated glycoprotein 2 2
MIRT499420 PLCG2 phospholipase C gamma 2 2 4
MIRT499820 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT500046 SDE2 SDE2 telomere maintenance homolog 2 6
MIRT500844 SYPL1 synaptophysin like 1 2 4
MIRT504518 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT505622 SLC25A37 solute carrier family 25 member 37 2 2
MIRT509134 STK4 serine/threonine kinase 4 2 2
MIRT509219 BUB3 BUB3, mitotic checkpoint protein 2 4
MIRT510752 SLC7A1 solute carrier family 7 member 1 2 2
MIRT512115 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT512317 ACTR2 ARP2 actin related protein 2 homolog 2 6
MIRT517395 BGN biglycan 2 4
MIRT518412 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 4
MIRT521362 RPL35A ribosomal protein L35a 2 2
MIRT525072 FRK fyn related Src family tyrosine kinase 2 2
MIRT525800 SOD2 superoxide dismutase 2 2 2
MIRT530430 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT541467 AURKA aurora kinase A 2 2
MIRT544303 TSPYL1 TSPY like 1 2 2
MIRT546415 SPRED3 sprouty related EVH1 domain containing 3 2 2
MIRT546582 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548764 CNN3 calponin 3 2 2
MIRT549809 KIAA0391 KIAA0391 2 2
MIRT550611 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT552227 FIG4 FIG4 phosphoinositide 5-phosphatase 2 4
MIRT554008 SPTLC1 serine palmitoyltransferase long chain base subunit 1 2 2
MIRT554116 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT555100 PURB purine rich element binding protein B 2 2
MIRT560290 HRH2 histamine receptor H2 2 2
MIRT560381 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT560800 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT560978 IWS1 IWS1, SUPT6H interacting protein 2 2
MIRT561161 BCL2L12 BCL2 like 12 2 2
MIRT562389 EN2 engrailed homeobox 2 2 2
MIRT562482 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT567784 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568831 TRIM67 tripartite motif containing 67 2 2
MIRT569555 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT572382 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575792 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT610505 CTBS chitobiase 2 4
MIRT616605 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT621780 TMEM87B transmembrane protein 87B 2 2
MIRT634217 TMEM192 transmembrane protein 192 2 2
MIRT639651 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT642500 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT643217 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT674822 KCNJ10 potassium voltage-gated channel subfamily J member 10 2 2
MIRT697356 ZNF426 zinc finger protein 426 2 2
MIRT704675 CHTOP chromatin target of PRMT1 2 2
MIRT708704 TFDP2 transcription factor Dp-2 2 2
MIRT709660 DFFB DNA fragmentation factor subunit beta 2 2
MIRT711280 SDR9C7 short chain dehydrogenase/reductase family 9C member 7 2 2
MIRT713733 SUCO SUN domain containing ossification factor 2 2
MIRT715006 TSPAN11 tetraspanin 11 2 2
MIRT718400 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4476 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4476 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-mir-4476 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-4476 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4476 Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-4476 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4476 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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